MCID: CRN024
MIFTS: 43

Corneal Disease

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Corneal Disease

MalaCards integrated aliases for Corneal Disease:

Name: Corneal Disease 12 15 17
Corneal Diseases 54 43 71
Corneal Disorders 42

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:10124
ICD9CM 34 371.9
MeSH 43 D003316
NCIt 49 C26731
SNOMED-CT 67 15250008
ICD10 32 H18.9
UMLS 71 C0010034

Summaries for Corneal Disease

MedlinePlus : 42 Your cornea is the outermost layer of your eye. It is clear and shaped like a dome. The cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. It also helps your eye to focus. If you wear contact lenses, they float on top of your corneas. Problems with the cornea include Refractive errors Allergies Infections Injuries Dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material Treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. NIH: National Eye Institute

MalaCards based summary : Corneal Disease, also known as corneal diseases, is related to keratitis, hereditary and keratoconus, and has symptoms including eye manifestations An important gene associated with Corneal Disease is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways/superpathways is Hypertrophy Model. The drugs tannic acid and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone, and related phenotypes are homeostasis/metabolism and vision/eye

Disease Ontology : 12 An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction.

Wikipedia : 74 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

Related Diseases for Corneal Disease

Diseases in the Corneal Disease family:

Rare Inflammatory/autoimmune Corneal Disorder Rare Corneal Disorder

Diseases related to Corneal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 32.8 NGF KRT3 KRT12 GJB2 CRYAA CCR6
2 keratoconus 32.5 VSX1 TUBA3D TGFBI TGFB2 SLC4A11 KRT3
3 corneal dystrophy, avellino type 32.3 TGFBI KRT3 COL8A2 CHST6
4 corneal dystrophy, meesmann, 1 32.2 TGFBI KRT3 KRT12 CRYAA COL8A2 CHST6
5 astigmatism 31.2 KRT3 KRT12 CRYAA
6 limbal stem cell deficiency 31.0 KRT3 KRT12 IL1A
7 corneal edema 30.9 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
8 keratoconjunctivitis sicca 30.9 NGF IL1A CCR6
9 corneal dystrophy 30.8 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
10 recurrent corneal erosion 30.7 TGFBI KRT3 KRT12 COL8A2 CHST6
11 corneal ectasia 30.7 VSX1 TUBA3D TGFBI COL8A2
12 eye disease 30.7 TGFBI TGFB2 NGF LCAT IL1A CRYAA
13 irregular astigmatism 30.7 VSX1 TGFBI SLC4A11 KRT3 KRT12 COL8A2
14 fuchs' endothelial dystrophy 30.6 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
15 stromal dystrophy 30.5 TGFBI SLC4A11 KRT3 KRT12 COL8A2 CHST6
16 dry eye syndrome 30.4 NGF CRYAA CCR6
17 corneal dystrophy, band-shaped 30.4 SLC4A11 COL8A2
18 intraocular pressure quantitative trait locus 30.4 ZEB1 TGFB2 CRYAA
19 lattice corneal dystrophy 30.3 TGFBI KRT12 GSN CHST6
20 corneal dystrophy, posterior polymorphous, 1 30.3 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
21 macular dystrophy, corneal 30.3 TGFBI KRT3 KRT12 COL8A2 CHST6
22 aniridia 1 30.3 KRT3 KRT12 CRYAA
23 glaucoma, primary open angle 30.3 TGFB2 CRYAA COL8A2
24 corneal dystrophy, gelatinous drop-like 30.2 TGFBI KRT3 KRT12 GSN COL8A2 CHST6
25 corneal degeneration 30.2 VSX1 TGFBI SLC4A11 KRT3 KRT12 COL8A2
26 open-angle glaucoma 30.0 TGFB2 CRYAA COL8A2
27 pars planitis 29.9 IL1A CCR6
28 rare inflammatory/autoimmune corneal disorder 12.1
29 rare corneal disorder 12.1
30 rare genetic inflammatory/autoimmune corneal disorder 12.1
31 rare genetic corneal disorder 12.1
32 keratoendotheliitis fugax hereditaria 11.4
33 corneal dystrophy, fuchs endothelial, 1 11.3
34 keratoconus 9 11.1
35 ring dermoid of cornea 10.9
36 megalocornea 10.9
37 peters-plus syndrome 10.9
38 corneal dystrophy, fuchs endothelial, 4 10.9
39 corneal dystrophy, fuchs endothelial, 6 10.9
40 corneal dystrophy, fuchs endothelial, 8 10.9
41 sclerocornea 10.9
42 cornea plana 10.9
43 corneal dystrophy and perceptive deafness 10.9
44 corneal dystrophy, fuchs endothelial, 2 10.9
45 corneal dystrophy, fuchs endothelial, 3 10.9
46 posterior corneal dystrophy 10.7 ZEB1 COL8A2
47 pseudopterygium 10.7 SLC4A11 KRT3 KRT12
48 secondary corneal edema 10.6 SLC4A11 COL8A2
49 schnyder corneal dystrophy 10.6 TGFBI KRT3 KRT12
50 corneal dystrophy, lisch epithelial 10.6 KRT3 KRT12 CHST6

Graphical network of the top 20 diseases related to Corneal Disease:



Diseases related to Corneal Disease

Symptoms & Phenotypes for Corneal Disease

UMLS symptoms related to Corneal Disease:


eye manifestations

MGI Mouse Phenotypes related to Corneal Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 CCR6 GJB2 GSN IL1A LCAT NGF
2 vision/eye MP:0005391 9.36 CHST6 COL8A2 GJB2 KRT12 LCAT NGF

Drugs & Therapeutics for Corneal Disease

Drugs for Corneal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
3
Timolol Approved Phase 4 26839-75-8 33624 5478
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
6
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
7
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
8
Brinzolamide Approved Phase 4 138890-62-7 68844
9
Travoprost Approved Phase 4 157283-68-6 5282226
10 Brimonidine Tartrate Phase 4 70359-46-5
11 Adrenergic beta-Antagonists Phase 4
12 Carbonic Anhydrase Inhibitors Phase 4
13 Pharmaceutical Solutions Phase 4
14 Ophthalmic Solutions Phase 4
15 Lubricant Eye Drops Phase 4
16 Mitogens Phase 4
17
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
18
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
19
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
20
Ofloxacin Approved Phase 3 82419-36-1 4583
21
Tobramycin Approved, Investigational Phase 3 32986-56-4 5496 36294
22
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
23
Cefazolin Approved Phase 3 25953-19-9 656510 33255
24
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
25
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
26
Gatifloxacin Approved, Investigational Phase 3 112811-59-3 5379
27
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
28
Cyclopentolate Approved Phase 3 512-15-2 2905
29
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
30 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
31
Besifloxacin Approved Phase 3 141388-76-3
32
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
33
Polyestradiol phosphate Approved Phase 3 28014-46-2
34
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
35
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
36
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
37
Tetracaine Approved, Vet_approved Phase 3 94-24-6 5411
38
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
39
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
40
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
41 Endothelial Growth Factors Phase 2, Phase 3
42 Angiogenesis Inhibitors Phase 2, Phase 3
43 Antineoplastic Agents, Immunological Phase 2, Phase 3
44 Triamcinolone diacetate Phase 2, Phase 3
45 Triamcinolone hexacetonide Phase 2, Phase 3
46 triamcinolone acetonide Phase 2, Phase 3
47 Anti-Bacterial Agents Phase 3
48 Antibiotics, Antitubercular Phase 3
49 Renal Agents Phase 3
50 Cytochrome P-450 Enzyme Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 100)
# Name Status NCT ID Phase Drugs
1 Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Hypo-osmolar Riboflavin Solution in Thin Corneas Completed NCT01485211 Phase 4 cross-linking with hypo-osmolar riboflavin
2 Effect of Corneal Preservation Time on Long-Term Graft Success Completed NCT01537393 Phase 4
3 Intrastromal Corneal Ring Segment Implantation for High Astigmatism on Postkeratoplasty Eyes Completed NCT01018797 Phase 4
4 Effect of Prophylactic Aqueous Suppression on Hyperencapsulation of Ahmed Glaucoma Valves Recruiting NCT01535768 Phase 4 Aqueous Suppressant Eye Drops
5 Randomized, Parallel Groups, Multicenter and Blind to Evaluators Clinical Trial, to Evaluate the Efficacy and Safety of PRGF-Endoret Eye Drops, in Patients With Stage 2 and 3 Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
6 Study of Safety and Efficacy of Photochemically Induced Collagen Cross-Linking at an Irradiance of 18 mW/cm2 as Constant or Pulsed Treatment in Eyes With Unstable Corneas Due to Keratoconus, Ectasia, or Post-Incisional Refractive Surgery Unknown status NCT02095730 Phase 3 Epithelium-On Riboflavin;Epithelium-Off Riboflavin
7 iDesign Aberrometer for the Refractive Treatment of Early Keratoconus Unknown status NCT02613780 Phase 3
8 A Phase III Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome Completed NCT02503189 Phase 3 KCT-0809 ophthalmic solution;Placebo
9 A Long-term Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome Completed NCT02503163 Phase 3 KCT-0809 ophthalmic solution
10 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia or Progressive Keratoconus Completed NCT00567671 Phase 2, Phase 3
11 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3 Bevacizumab (Avastin)
12 Phase 3, Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy: SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
13 Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for the Treatment of Infectious Keratitis Recruiting NCT02717871 Phase 3 Cefazolin in combination with either tobramycin or gentamicin;Cycloplegic agents (cyclopentolate 1% eye drops);Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin );Corticosteroids (prednisolone acetate 0.5% or 1% eye drops)
14 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
15 Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking and Intacs for Treatment of Keratoconus and Corneal Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
16 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Enrolling by invitation NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
17 Topography Guided Excimer Laser Surface Ablation in Combination With Corneal Cross-linking (CCL) in Patients With Progressive Ectatic Corneal Disorders. Terminated NCT01682993 Phase 3
18 An Extension Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome Terminated NCT02503176 Phase 3 KCT-0809 ophthalmic solution
19 Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
20 A Multi-center, Placebo-Controlled, Randomized, Parallel Group, Dose-Ranging Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure Following Penetrating Keratoplasty With LX201 Implantation in Subjects Who Are at Increased Immunological Risk Terminated NCT00447187 Phase 3 LX201
21 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
22 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Withdrawn NCT01643252 Phase 3 riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system;placebo: 0.0% riboflavin ophthalmic solution with the KXL system
23 Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation Unknown status NCT02148016 Phase 1, Phase 2 Levofloxacin;Betamethasone;Limbal stem cells (LSCs)
24 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
25 A Randomized, Double Blind, Placebo Controlled, Phase II Study of KCT-0809 in Patients With Dry Eye Syndrome Completed NCT01427816 Phase 2 KCT-0809;KCT-0809;Placebo
26 A Randomized, Double Blind, Placebo Controlled, Phase 2 Study of KLS-0611 in Patients With Dry Eye Syndromes Completed NCT00721656 Phase 2 Placebo;KLS-0611
27 A Randomized, Double Blind, Placebo Controlled, Parallel Group Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes Completed NCT01692145 Phase 2 KCT-0809;Placebo
28 A Late Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes Completed NCT01890941 Phase 2 KCT-0809 ophthalmic solution;Placebo
29 A Randomized, Double Blind, Placebo Controlled, Exploratory Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes Completed NCT01211951 Phase 2 KCT-0809;KCT-0809;KCT-0809;Placebo
30 Evaluation the Effect of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Epithelium Healing (Phase I and II Clinical Trial) Completed NCT02746848 Phase 1, Phase 2
31 Safety and Efficacy of Topical Pazopanib in Treatment of Corneal Neovascularization Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
32 A Controlled Phase 2 Study for Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel Recruiting NCT03994406 Phase 2 CLM2 topical gel;Placebo topical gel
33 COLLAGEN CROSS-LINKING WITH ULTRAVIOLET-A IN ASYMMETRIC CORNEAS Active, not recruiting NCT03029104 Phase 2
34 The Improvement of Limbal Epithelial Culture Technique for the Treatment of Unilateral Limbal Insufficiency by Using Collagenase to Isolate Limbal Stem Cells Unknown status NCT02202642 Phase 1
35 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia Recruiting NCT04094090 Phase 1
36 Evaluation of Biosynthetic Constructs as Replacement for Donor Corneas as Graft Material for Corneal Transplantation Withdrawn NCT02374723 Phase 1
37 Cornea Donor Study Unknown status NCT00006411
38 Effect of Brimonidine on Corneal Thickness Unknown status NCT01250236 brimonidine 0.1%;placebo
39 Implant the Corneal Stroma to the Diseased Cornea in Order to Cure Keratoconus Unknown status NCT03229239
40 Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI Unknown status NCT01307527 Riboflavin
41 Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia Unknown status NCT01123057
42 Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases Unknown status NCT02932852 Early Phase 1
43 Observation on Effect of Anti--inflammatory and Inhibition of Recurrence on the Herpes Simplex Keratitis After Topical NSAIDs Administration Unknown status NCT03013959 Pranoprofen
44 The Effect of Ophthalmic Solutions on Contact Lenses Used After Surgery for Congenital Cataract Investigated in Vivo Unknown status NCT03125785
45 The Asia Cornea Society Infectious Keratitis Study Unknown status NCT01560208
46 Using AS-OCT to Assess the Role of Age and Region in the Morphology and Epithelial Thickness of Limbus Unknown status NCT02500134
47 Retrospective Study of the in Vivo Confocal Microscopic Findings and the Treatment Outcome of Acanthamoebic Keratitis Unknown status NCT02763605
48 Corneal Endothelial Cell Loss After Trabeculectomy Versus Combined Trabeculectomy Phakoemulsification and IOL Implantation Unknown status NCT03107000
49 A Pilot Study Using the Dynamic Light Scattering Device (DLS) Combined With Keratoscopy on the Cornea in Vivo Completed NCT00050466
50 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin

Search NIH Clinical Center for Corneal Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


deferoxamine mesylate

Cochrane evidence based reviews: corneal diseases

Genetic Tests for Corneal Disease

Anatomical Context for Corneal Disease

MalaCards organs/tissues related to Corneal Disease:

40
Eye, Endothelial, Bone, Testes, T Cells, Neutrophil, Skin

Publications for Corneal Disease

Articles related to Corneal Disease:

(show top 50) (show all 1757)
# Title Authors PMID Year
1
Recent innovations with drugs in clinical trials for neurotrophic keratitis and refractory corneal ulcers. 42
31596151 2019
2
Antibiotics for trachoma. 42
31554017 2019
3
Tear Film Osmolarity, Ocular Surface Disease and Glaucoma: A Review. 42
31345142 2019
4
Anterior segment dysgenesis after overexpression of transforming growth factor-beta-induced gene, beta igh3, in the mouse eye. 54 61
17982418 2007
5
Expression of Sp1 and KLF6 in the developing human cornea. 54 61
17893646 2007
6
Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene. 54 61
17653042 2007
7
[Autosomal dominant granular corneal dystrophy caused by a TGFBI gene mutation in a Mexican family]. 54 61
16888689 2006
8
Keratoepithelin in secondary corneal amyloidosis. 54 61
16331487 2006
9
Influence of interleukin-1alpha and tumor necrosis factor-alpha production on corneal graft survival. 54 61
16489698 2006
10
Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study. 54 61
16083875 2006
11
The molecular genetics of the corneal dystrophies--current status. 54 61
12700042 2003
12
Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235. 54 61
12140204 2002
13
Cell density regulated expression of transcription factor Sp1 in corneal stromal cultures. 54 61
11428859 2001
14
Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas. 54 61
10752942 2000
15
Improvement of corneal sensation and tear dynamics in diabetic patients by oral aldose reductase inhibitor, ONO-2235: a preliminary study. 54 61
8776562 1996
16
Topography and pachymetry maps for mouse corneas using optical coherence tomography. 61
31704241 2020
17
Modeling Changes in Corneal Parameters With Age: Implications for Corneal Disease Detection. 61
31469999 2020
18
A Modified Customized Rigid Gas Permeable Contact Lens to Improve Visualization During Phacoemulsification in Ectatic Corneas. 61
31976337 2020
19
Corneal Ulcer Treated with 0.66% Nanoemulsion Povidone-Iodine: A Case Report. 61
31974332 2020
20
The clinical and microbiological features and outcomes of fungal keratitis over 9 years in Sydney, Australia. 61
31556179 2020
21
Clinical presentations, genotypic diversity and phylogenetic analysis of Acanthamoeba species causing keratitis. 61
31846414 2020
22
Quantification of collagen structural changes during chick corneal development. 61
31465146 2020
23
Use of four-layer porcine small intestinal submucosa alone as a scaffold for the treatment of deep corneal defects in dogs and cats: preliminary results. 61
31937546 2020
24
Canine Corneal Stromal Cells have multipotent mesenchymal stromal cell properties in vitro. 61
31973649 2020
25
Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model. 61
31988856 2020
26
Cataract surgery in corneal transplantation. 61
31770165 2020
27
Effect of Tempol, a Membrane-Permeable Free Radical Scavenger, on In Vitro Model of Eye Inflammation on Rabbit Corneal Cells. 61
31825758 2019
28
Using a multilayer perceptron in intraocular lens power calculation. 61
31856986 2019
29
Successful development and clinical translation of a novel anterior lamellar artificial cornea. 61
31373143 2019
30
Corneal topography in clinical practice. 61
31727328 2019
31
Relationship between optic disc hemorrhage and corneal hysteresis. 61
31879066 2019
32
High-risk Corneal Transplantation: Recent Developments and Future Possibilities. 61
31765363 2019
33
Iridocorneal endothelial syndrome in a patient with keratoconus - a case report. 61
31711443 2019
34
VEGF188 promotes corneal reinnervation after injury. 61
31672940 2019
35
Gonadotropins in Keratoconus: The Unexpected Suspects. 61
31766771 2019
36
Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty. 61
31044553 2019
37
Evaluation of equine corneal disease using spectral domain optical coherence tomography (SD-OCT). 61
30767400 2019
38
The use of autologous serum eye drops for the treatment of ocular surface disorders. 61
31798853 2019
39
Awareness and attitudes toward corneal donation among applicants and staff of a driver, vehicle and licensing authority (DVLA) in Ghana. 61
31718617 2019
40
Studies on bacterial cellulose/poly vinyl alcohol (BC/PVA) hydrogel composites as tissue-engineered corneal stroma. 61
31715589 2019
41
Corneal nerves in health and disease. 61
31075321 2019
42
Efficacy and Safety of Transglutaminase-Induced Corneal Stiffening in Rabbits. 61
31853423 2019
43
Glaucoma Drainage Devices and Reasons For Keratoplasty. 61
31393312 2019
44
Ayurvedic management of Ulcerative Keratitis - A case report. 61
30683497 2019
45
The Regulating Role of SB216763 in Pseudomonas aeruginosa Keratitis. 61
31625371 2019
46
Population-based assessment of visual impairment and pattern of corneal disease: results from the CORE (Corneal Opacity Rural Epidemiological) study. 61
31628205 2019
47
In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances. 61
31605471 2019
48
Second harmonic generation imaging reveals asymmetry in the rotational helicity of collagen lamellae in chicken corneas. 61
31646043 2019
49
[Unmet research and developmental needs in ophthalmology : A consensus-based road map of the European Vision Institute for 2019-2025]. 61
31388757 2019
50
Clinical course of Acanthamoeba keratitis by genotypes T4 and T8 in Hungary. 61
30835133 2019

Variations for Corneal Disease

Expression for Corneal Disease

Search GEO for disease gene expression data for Corneal Disease.

Pathways for Corneal Disease

Pathways related to Corneal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.92 ZEB1 IL1A

GO Terms for Corneal Disease

Cellular components related to Corneal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TGFBI TGFB2 TFF3 NGF LCAT IL1A
2 extracellular region GO:0005576 9.28 TGFBI TGFB2 TFF3 NLRP3 NGF LCAT

Biological processes related to Corneal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.92 VSX1 TGFBI KRT12 CRYAA

Sources for Corneal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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