MCID: CRN009
MIFTS: 29

Corneal Ectasia

Categories: Neuronal diseases

Aliases & Classifications for Corneal Ectasia

MalaCards integrated aliases for Corneal Ectasia:

Name: Corneal Ectasia 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1436
ICD9CM 34 371.71
SNOMED-CT 67 14748007
ICD10 32 H18.71
UMLS 71 C0155135

Summaries for Corneal Ectasia

MalaCards based summary : Corneal Ectasia is related to keratoconus 1 and regular astigmatism. An important gene associated with Corneal Ectasia is KERA (Keratocan). The drugs Dextrans and Plasma Substitutes have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are FOXO1 nuclear localization and FOXO1 nuclear localization

Related Diseases for Corneal Ectasia

Diseases related to Corneal Ectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 keratoconus 1 32.0 ZNF469 VSX1
2 regular astigmatism 30.3 ZNF469 VSX1
3 epithelial basement membrane dystrophy 29.5 TGFBI KRT3
4 keratoconus 29.2 ZNF469 VSX1 TUBA3D TGFBI RAB3GAP1 LCN12
5 corneal edema 29.2 VSX1 TGFBI KRT3 KERA COL8A2
6 corneal degeneration 29.1 VSX1 TGFBI KRT3 KERA COL8A2
7 corneal endothelial dystrophy 28.8 ZNF469 VSX1 TGFBI KRT3 COL8A2
8 corneal disease 28.6 ZNF469 VSX1 TUBA3D TGFBI KRT3 KERA
9 irregular astigmatism 27.8 ZNF765 ZNF469 VSX1 TGFBI RAB3GAP1 KRT3
10 keratoconus 9 11.2
11 astigmatism 10.7
12 myopia 10.5
13 refractive error 10.3
14 pellucid marginal degeneration 10.3
15 ocular motor apraxia 10.3
16 cataract 10.2
17 osgood-schlatter's disease 10.2 VSX1 COL8A2
18 corneal dystrophy, endothelial, x-linked 10.2 VSX1 COL8A2
19 corneal dystrophy, posterior polymorphous, 2 10.1 VSX1 COL8A2
20 keratitis, hereditary 10.1
21 severe cutaneous adverse reaction 10.1
22 erythema multiforme 10.1
23 presbyopia 10.1
24 erythema multiforme major 10.1
25 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.1
26 corneal dystrophy and perceptive deafness 10.1 VSX1 COL8A2
27 brittle bone disorder 10.1 ZNF469 VSX1 MIA2
28 sclerocornea 10.0
29 keratoconjunctivitis 10.0
30 martsolf syndrome 10.0 ZNF469 RAB3GAP1
31 corneal ulcer 10.0 KRT3 KERA
32 tyrosinemia, type ii 9.9 KRT3 COL8A2
33 ige responsiveness, atopic 9.9
34 orbital margin, hypoplasia of 9.9
35 retinal detachment 9.9
36 strabismus 9.9
37 cohen syndrome 9.9
38 familial mediterranean fever 9.9
39 macular degeneration, age-related, 1 9.9
40 pars planitis 9.9
41 keratoconus 3 9.9
42 keratoconus 5 9.9
43 interstitial nephritis, karyomegalic 9.9
44 cornea plana 9.9
45 suppression amblyopia 9.9
46 amblyopia 9.9
47 microcephaly 9.9
48 brucellosis 9.9
49 corneal neovascularization 9.9
50 retinal vasculitis 9.9

Graphical network of the top 20 diseases related to Corneal Ectasia:



Diseases related to Corneal Ectasia

Symptoms & Phenotypes for Corneal Ectasia

GenomeRNAi Phenotypes related to Corneal Ectasia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 FOXO1 nuclear localization GR00247-A-1 9.1 DOCK9 KERA KRT82
2 FOXO1 nuclear localization GR00247-A-2 9.1 DOCK9 KERA KRT82

Drugs & Therapeutics for Corneal Ectasia

Drugs for Corneal Ectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dextrans Phase 3
2 Plasma Substitutes Phase 3
3 Anticoagulants Phase 3
4 Blood Substitutes Phase 3
5
Flavin mononucleotide Approved, Investigational 146-17-8 643976
6
Ketotifen Approved 34580-13-7, 34580-14-8 3827
7 Antibiotics, Antitubercular
8 Anesthetics
9 Anti-Bacterial Agents
10 Mydriatics
11 Lubricant Eye Drops

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia or Progressive Keratoconus Completed NCT00567671 Phase 2, Phase 3
2 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Completed NCT00674661 Phase 3 riboflavin ophthalmic solution
3 Phase III Study of Corneal Collagen Cross-linking Using Two Different Techniques. Recruiting NCT01708538 Phase 3 CXL
4 Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking and Intacs for Treatment of Keratoconus and Corneal Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
5 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
6 Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
7 Long Term Safety and Effectiveness of the VEGA UV-A System for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Post-Refractive Corneal Ectasia Terminated NCT01398852 Phase 3 Riboflavin
8 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Withdrawn NCT01643252 Phase 3 riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system;placebo: 0.0% riboflavin ophthalmic solution with the KXL system
9 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
10 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
11 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions Recruiting NCT04401865 Phase 1, Phase 2
12 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia Recruiting NCT04094090 Phase 1
13 Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia Unknown status NCT01123057
14 Risk Assessment for Corneal Ectasia Following Laser in Situ Keratomileusis Unknown status NCT03708575
15 Pilot Study of Excimer Laser Topography-Computer Assisted Treatment (T-Cat) Combined With Corneal Collagen Cross-linking With Riboflavin and UV Light Completed NCT00777322
16 Combined Technique of Corneal Remodeling to Treat Ectasia Completed NCT04405882
17 A Phase IV Observational Registry to Assess the Safety and Durability of Effect of Corneal Collagen Cross-linking With Photrexa Viscous, Photrexa, and the KXL System in Patients With Corneal Ectasia Following Refractive Surgery Recruiting NCT03319082
18 Dresden Corneal Disease and Treatment Study - Analysis for Quality Inspection of Follow-up and Treatment Procedures of Corneal Diseases of the Department of Ophthalmology (University Hospital Carl Gustav Carus Dresden) Recruiting NCT04251143
19 Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics - Selection and Evaluation of Eligible Patients With Certain Ocular Diseases Associated With Biomechanical Alterations Recruiting NCT04475900
20 A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia Recruiting NCT02118922
21 INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia Not yet recruiting NCT02512432

Search NIH Clinical Center for Corneal Ectasia

Genetic Tests for Corneal Ectasia

Anatomical Context for Corneal Ectasia

MalaCards organs/tissues related to Corneal Ectasia:

40
Eye, Endothelial

Publications for Corneal Ectasia

Articles related to Corneal Ectasia:

(show top 50) (show all 601)
# Title Authors PMID Year
1
Cosmetic Keratopigmentation in Sighted Eyes: Medium- and Long-term Clinical Evaluation. 61
32740012 2021
2
Eye Rubbing and Transient Corneal Ectasia Detected by Topography in a Pediatric Patient. 61
32858542 2021
3
Updates in the Management of Corneal Ectasia. 61
33337792 2021
4
Correlation between Keratoconus and Pollution. 61
33502925 2021
5
Microbial Keratitis After Corneal Collagen Cross-Linking for Corneal Ectasia. 61
33534235 2021
6
Outcomes of Corneal Topography among Progressive Keratoconus Patients 12 months following Corneal Collagen Cross-Linking. 61
33442228 2021
7
Case Report: Successful Corneal Crosslinking in a Patient with Corneal Ectasia Associated with Stevens-Johnson Syndrome. 61
33394926 2021
8
A review of imaging modalities for detecting early keratoconus. 61
32678352 2021
9
Orientation-specific long-term neural adaptation of the visual system in keratoconus. 61
33190099 2021
10
Impact of Scleral Contact Lens Use on the Rate of Corneal Transplantation for Keratoconus. 61
32452985 2021
11
Translation and validation of the "Questionnaire for research on keratoconus results" (KORQ) in the Colombian population. 61
32788064 2020
12
Exome sequencing identification of susceptibility genes in Chinese patients with keratoconus. 61
32744102 2020
13
Randomised controlled trial of corneal vs. scleral rigid gas permeable contact lenses for keratoconus and other ectatic corneal disorders. 61
31924530 2020
14
Tear proteomic profile in three distinct ocular surface diseases: keratoconus, pterygium, and dry eye related to graft-versus-host disease. 61
33372592 2020
15
Lamellar Keratoplasty for Advanced Keratoconus. 61
33208629 2020
16
Corneal Ectasia Induced by Prostaglandin Analogues. 61
32910010 2020
17
Long-term outcome of custom toric intraocular lens for treating high astigmatism in case of cataract associated with pellucid marginal corneal degeneration. 61
33245061 2020
18
Refractive surgery with simultaneous collagen cross-linking for borderline corneas - A review of different techniques, their protocols and clinical outcomes. 61
33229650 2020
19
Outcome comparison between wavefront-guided and wavefront-optimized photorefractive keratectomy: A systematic review and meta-analysis. 61
33229644 2020
20
Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: a systematic review and meta-analysis. 61
33383093 2020
21
Bilateral spontaneous filtering blebs. 61
33020746 2020
22
Post-FDA Approval Results of Epithelium-Off, Full-Fluence, Dresden Protocol Corneal Collagen Crosslinking in the USA. 61
33029700 2020
23
Toll-like receptors as diagnostic targets in pellucid marginal degeneration. 61
32890481 2020
24
Femtosecond Laser-Assisted Allogenic Lenticule Implantation for Corneal Ectasia After LASIK: A 3-Year In Vivo Confocal Microscopic Investigation. 61
33170278 2020
25
Outcomes of Scleral Contact Lens Use in Veteran Population. 61
31794543 2020
26
Corneal suture for acute corneal hydrops secondary to post-LASIK ectasia: a case report. 61
33470283 2020
27
Evidence of corneal ectasia susceptibility: a new definition of forme fruste keratoconus. 61
33105248 2020
28
Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study. 61
32983439 2020
29
A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus. 61
31917136 2020
30
Corneal topography in preoperative evaluation for laser keratorefractive surgery - a review. 61
33367171 2020
31
Simultaneous photorefractive keratectomy and accelerated collagen cross-linking in high-risk refractive surgery (Tehran protocol): 3-year outcomes. 61
32607947 2020
32
Laser-assisted in situ keratomileusis long term outcomes in late adolescence. 61
33124450 2020
33
Nonlinear optical crosslinking (NLO CXL) for correcting refractive errors. 61
32846150 2020
34
Intra corneal ring segment implantation with lenticule assisted stromal augmentation for crosslinking in thin corneas. 61
32566797 2020
35
Tomographically normal partner eye in very asymmetrical corneal ectasia: biomechanical analysis. 61
32947382 2020
36
The Impact of Misaligned Wavefront-guided Correction in a Scleral Lens for the Highly Aberrated Eye. 61
32976324 2020
37
Clinical outcomes of KeraVio using violet light: emitting glasses and riboflavin drops for corneal ectasia: a pilot study. 61
32892163 2020
38
Gabapentin for presumed neuropathic ocular pain. 61
32760852 2020
39
A temporary corneal ectasia following airbag trauma. 61
32671289 2020
40
Atypical Corneal Ectasia Associated With Vitamin C Deficiency. 61
32301811 2020
41
Genetic and Environmental Risk Factors for Keratoconus. 61
32320633 2020
42
Whole exome sequencing highlights variants in association with Keratoconus in Jordanian families. 61
32887565 2020
43
Epithelium-Off vs. transepithelial corneal collagen crosslinking in progressive keratoconus: 3 years of follow-up. 61
32883647 2020
44
Effect of the variability in implantation depth of intracorneal ring segments using the femtosecond laser technology in corneal ectasia. 61
31113256 2020
45
Risk factors for postlaser refractive surgery corneal ectasia. 61
32398416 2020
46
Ten years experience of corneal collagen cross-linking: An observational study of 6120 cases. 61
32498548 2020
47
Corneal collagen cross-linking for bacterial infectious keratitis. 61
32557558 2020
48
Intracorneal ring segments followed by toric pseudoaccomodating IOL for treatment of patients with corneal ectasia and cataract. 61
32368687 2020
49
Advanced Surface Ablation in Mild (Fruste) Keratoconus: A Case Report. 61
32323165 2020
50
Toric intraocular lens in asymmetric astigmatism. 61
31982994 2020

Variations for Corneal Ectasia

Expression for Corneal Ectasia

Search GEO for disease gene expression data for Corneal Ectasia.

Pathways for Corneal Ectasia

GO Terms for Corneal Ectasia

Cellular components related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 9.13 TGFBI COL8A2 COL4A3
2 extracellular matrix GO:0031012 8.92 TGFBI KERA COL8A2 COL4A3

Biological processes related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.8 VSX1 TGFBI KERA

Molecular functions related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL8A2 COL4A3
2 extracellular matrix structural constituent GO:0005201 8.8 TGFBI COL8A2 COL4A3

Sources for Corneal Ectasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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