MCID: CRN009
MIFTS: 28

Corneal Ectasia

Categories: Eye diseases

Aliases & Classifications for Corneal Ectasia

MalaCards integrated aliases for Corneal Ectasia:

Name: Corneal Ectasia 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:1436
ICD9CM 35 371.71
SNOMED-CT 68 14748007
ICD10 33 H18.71
UMLS 72 C0155135

Summaries for Corneal Ectasia

MalaCards based summary : Corneal Ectasia is related to keratoconus and corneal disease. An important gene associated with Corneal Ectasia is KERA (Keratocan). The drugs Dextrans and Plasma Substitutes have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Related Diseases for Corneal Ectasia

Diseases related to Corneal Ectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 keratoconus 32.2 VSX1 KERA
2 corneal disease 30.1 VSX1 KERA
3 keratoconus 1 11.6
4 keratoconus 9 11.5
5 astigmatism 10.7
6 myopia 10.6
7 pellucid marginal degeneration 10.4
8 ocular motor apraxia 10.3
9 refractive error 10.3
10 irregular astigmatism 10.2
11 keratitis, hereditary 10.1
12 cataract 10.1
13 severe cutaneous adverse reaction 10.1
14 erythema multiforme 10.1
15 sclerocornea 10.1
16 corneal edema 10.1
17 presbyopia 10.1
18 corneal degeneration 10.1
19 keratoconjunctivitis 10.1
20 erythema multiforme major 10.1
21 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.1
22 corneal dystrophy, fuchs endothelial, 1 9.9
23 orbital margin, hypoplasia of 9.9
24 retinal detachment 9.9
25 strabismus 9.9
26 cohen syndrome 9.9
27 corneal endothelial dystrophy 9.9
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
29 familial mediterranean fever 9.9
30 macular degeneration, age-related, 1 9.9
31 pars planitis 9.9
32 keratoconus 3 9.9
33 keratoconus 2 9.9
34 intraocular pressure quantitative trait locus 9.9
35 keratoconus 5 9.9
36 interstitial nephritis, karyomegalic 9.9
37 cornea plana 9.9
38 epithelial basement membrane dystrophy 9.9
39 suppression amblyopia 9.9
40 amblyopia 9.9
41 corneal neovascularization 9.9
42 retinal vasculitis 9.9
43 regular astigmatism 9.9
44 punctate epithelial keratoconjunctivitis 9.9
45 bell's palsy 9.9
46 iritis 9.9
47 neovascular glaucoma 9.9
48 keratopathy 9.9
49 juvenile rheumatoid arthritis 9.9
50 vasculitis 9.9

Graphical network of the top 20 diseases related to Corneal Ectasia:



Diseases related to Corneal Ectasia

Symptoms & Phenotypes for Corneal Ectasia

Drugs & Therapeutics for Corneal Ectasia

Drugs for Corneal Ectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dextrans Phase 3
2 Plasma Substitutes Phase 3
3 Anticoagulants Phase 3
4 Blood Substitutes Phase 3
5
Prednisolone phosphate Approved, Vet_approved 302-25-0
6
Methylprednisolone hemisuccinate Approved 2921-57-5
7
Methylprednisolone Approved, Vet_approved 83-43-2 6741
8
Gatifloxacin Approved, Investigational 112811-59-3 5379
9
Dipivefrin Approved 52365-63-6 3105
10
Prednisolone Approved, Vet_approved 50-24-8 5755
11
Flavin Mononucleotide Approved, Investigational 146-17-8 643976
12
Ketotifen Approved 34580-13-7, 34580-14-8 3827
13
Prednisolone hemisuccinate Experimental 2920-86-7
14
Imidacloprid Vet_approved 105827-78-9 86418
15 Methylprednisolone Acetate
16 Anti-Inflammatory Agents
17 Prednisolone acetate
18 Anesthetics
19 Anti-Bacterial Agents
20 Mydriatics
21 Antibiotics, Antitubercular
22 Lubricant Eye Drops
23 Cholinergic Agents
24 Neurotransmitter Agents

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial Unknown status NCT01604135 Phase 3
2 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia or Progressive Keratoconus Completed NCT00567671 Phase 2, Phase 3
3 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Completed NCT00674661 Phase 3 riboflavin ophthalmic solution
4 Phase III Study of Corneal Collagen Cross-linking Using Two Different Techniques. Recruiting NCT01708538 Phase 3 CXL
5 Randomized Comparison of Standard vs. Accelerated Corneal Crosslinking for Treatment of Progressive Keratoconus or Ectasia Recruiting NCT03922542 Phase 2, Phase 3
6 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
7 Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking and Intacs for Treatment of Keratoconus and Corneal Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
8 Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin Active, not recruiting NCT01152541 Phase 3 Riboflavin/Dextran;Hypotonic Riboflavin
9 Long Term Safety and Effectiveness of the VEGA UV-A System for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Post-Refractive Corneal Ectasia Terminated NCT01398852 Phase 3 Riboflavin
10 Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
11 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
12 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Withdrawn NCT01643252 Phase 3 riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system;placebo: 0.0% riboflavin ophthalmic solution with the KXL system
13 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
14 Evaluation of Two Riboflavin Dosing Regimens for Corneal Collagen Cross-Linking in Eyes With Progressive Keratoconus or Ectasia Completed NCT01143389 Phase 2 Riboflavin
15 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions Recruiting NCT03918408 Phase 1
16 Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia Unknown status NCT01123057
17 Collagen Cross-linking With Riboflavin in a Hypotonic Solution, With UV Light, on Corneas Less Than 400 Microns Thick: an Exploratory Study. Unknown status NCT00890266
18 Intacs for Keratoconus Unknown status NCT00347230
19 Accelerated Versus Standard Corneal Cross Linking in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty: A Long Term Randomized Trial. Completed NCT03791684
20 Two Years Follow up of Corneal Cor Cross-linking and Refractive Surface Ablation in Patients With Asymmetric Corneal Topography Completed NCT02943967
21 Pilot Study of Excimer Laser Topography-Computer Assisted Treatment (T-Cat) Combined With Corneal Collagen Cross-linking With Riboflavin and UV Light Completed NCT00777322
22 Protease and Cytokine Composition in Post Lens Tear Reservoir of Scleral Lenses for Keratoconic Eyes Completed NCT02806921
23 Comparison of Corneal Stromal Tissue Consumption Values Estimated When Programming the Intervention Versus the Values Measured by Pre and Postoperative Topography Completed NCT02519673
24 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
25 A Phase IV Observational Registry to Assess the Safety and Durability of Effect of Corneal Collagen Cross-linking With Photrexa Viscous, Photrexa, and the KXL System in Patients With Corneal Ectasia Following Refractive Surgery Recruiting NCT03319082
26 A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia Recruiting NCT02118922
27 Corneal Elastography and Patient Specific Modeling Recruiting NCT03030755
28 A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea Recruiting NCT03220529
29 Comparison of Clinical Outcomes of Small-incision Lenticule Extraction (SMILE) Between Different Cap Thickness. Recruiting NCT03584555
30 Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking Recruiting NCT03095235
31 International Multicenter Study on Small Incision Lenticule Extraction(SMILE) Surgery Recruiting NCT02844556
32 Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus Recruiting NCT03647046
33 The Role of Anterior Segment Optical Coherence Tomography in Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking. Recruiting NCT03879421
34 Risk Assessment for Corneal Ectasia Following Laser in Situ Keratomileusis Not yet recruiting NCT03708575
35 INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia Not yet recruiting NCT02512432
36 Comparison of Anterior and Posterior Corneal Astigmatism in Patients With Keratoconus and Controls Not yet recruiting NCT03450213

Search NIH Clinical Center for Corneal Ectasia

Genetic Tests for Corneal Ectasia

Anatomical Context for Corneal Ectasia

MalaCards organs/tissues related to Corneal Ectasia:

41
Eye, Testes, Endothelial

Publications for Corneal Ectasia

Articles related to Corneal Ectasia:

(show top 50) (show all 520)
# Title Authors PMID Year
1
The Proteins of Keratoconus: a Literature Review Exploring Their Contribution to the Pathophysiology of the Disease. 38
31363996 2019
2
Ten-Year Outcomes of Progressive Keratoconus Management With the Athens Protocol (Topography-Guided Partial-Refraction PRK Combined With CXL). 38
31393985 2019
3
Review of laser vision correction (LASIK, PRK and SMILE) with simultaneous accelerated corneal crosslinking - long-term results. 38
31411927 2019
4
Reliability of the Evidence Addressing Treatment of Corneal Diseases: A Summary of Systematic Reviews. 38
31070698 2019
5
Autosomal recessive non-syndromic keratoconus: Homozygous frameshift variant in the candidate novel gene GALNT14. 38
31362688 2019
6
Resolution of epithelial ingrowth after combined photorefractive keratectomy and corneal crosslinking in a patient with post-LASIK ectasia. 38
31080047 2019
7
Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape. 38
31316864 2019
8
Progressive corneal ectasia after LASIK in an eye that already had intrastromal corneal ring segments implantation and corneal crosslinking: June consultation #1. 38
31146939 2019
9
To See or Not to See: A Systematic Review of the Importance of Human Ocular Surface Cytokine Biosignatures in Ocular Allergy. 38
31226821 2019
10
Detection of Subclinical Corneal Ectasia Using Corneal Tomographic and Biomechanical Assessments in a Japanese Population. 38
31185104 2019
11
Management of Descemet Membrane's Folds After Deep Anterior Lamellar Keratoplasty: Descemet Membrane-Tucking Technique. 38
30844841 2019
12
Corneal Cross-Linking: The Science Beyond the Myths and Misconceptions. 38
30882538 2019
13
False corneal ectasia in patients referred for corneal crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal rings. 38
31109479 2019
14
Vernal Keratoconjunctivitis. 38
30550738 2019
15
Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: protocol for a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. 38
31133582 2019
16
Effect of the variability in implantation depth of intracorneal ring segments using the femtosecond laser technology in corneal ectasia. 38
31113256 2019
17
Comparison of Wavefront-guided and Best Conventional Scleral Lenses after Habituation in Eyes with Corneal Ectasia. 38
30943184 2019
18
Protocol for a systematic review, meta-analysis, and trial sequential analysis of clinical outcomes following accelerated versus conventional corneal collagen cross-linking for corneal ectasia. 38
30947752 2019
19
Long-term Outcomes of a New Surgical Technique for Corneal Remodeling in Corneal Ectasia. 38
30984984 2019
20
Increased Corneal Ectasia Risk in Patients with Familial Mediterranean Fever. 38
30482054 2019
21
Indications and Surgical Techniques for Corneal Transplantation at a Tertiary Referral Center. 38
31114647 2019
22
Diffuse lamellar keratitis after epi-off corneal crosslinking: An under-recognized complication? 38
30705998 2019
23
[The effects of corneal cross-linking on intraocular pressure measurement in keratoconus]. 38
30679128 2019
24
Novel dynamic corneal response parameters in a practice use: a critical review. 38
30760270 2019
25
Incidence and associations of intracorneal ring segment explantation. 38
30509748 2019
26
Contribution of Fourier-domain optical coherence tomography to the diagnosis of keratoconus progression. 38
30367937 2019
27
Corneal ectasia associated with postoperative hypotony. 38
30851798 2019
28
Unilateral ectasia after small-incision lenticule extraction. 38
30573402 2019
29
Bilaterally Asymmetric Corneal Ectasia Following SMILE With Asymmetrically Reduced Stromal Molecular Markers. 38
30633782 2019
30
Management of Corneal Ectasia after LASIK with Phototherapeutic Keratectomy Combined with Photorefractive Keratectomy and Collagen Cross-Linking. 38
30906586 2019
31
Corneal Ectasia Preferred Practice Pattern®. 38
30366794 2019
32
Post-LASIK Ectasia: Twenty Years of a Conundrum. 38
30664391 2019
33
Collagen Cross-Linking in the Management of Microbial Keratitis. 38
29308960 2019
34
Yield of Display Modules of Corneal Tomography for Early Diagnosis of Corneal Ectasia. 38
31234630 2019
35
Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities. 38
30191404 2018
36
Characteristics and risk factors of recurrent keratoconus over the long term after penetrating keratoplasty. 38
30196480 2018
37
Appropriate Sequence of Combined Intracorneal Ring Implantation and Corneal Collagen Cross-Linking in Keratoconus: A Systematic Review and Meta-Analysis. 38
30211742 2018
38
Goniosynechialysis for secondary angle closure glaucoma in aphakic patient after pars plana vitrectomy. 38
30101207 2018
39
Transepithelial versus epithelium-off corneal crosslinking for corneal ectasia. 38
30314751 2018
40
Enhanced Tomographic Assessment to Detect Corneal Ectasia Based on Artificial Intelligence. 38
30098348 2018
41
The Impact of Scleral Contact Lens Vault on Visual Acuity and Comfort. 38
28953598 2018
42
Biomechanics and structure of the cornea: implications and association with corneal disorders. 38
29857022 2018
43
Simultaneous Estimation of Corneal Topography, Pachymetry, and Curvature. 38
29994760 2018
44
Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus. 38
30458789 2018
45
Characterization of the effect of intracorneal ring segment in corneal ectasia after laser refractive surgery. 38
30384777 2018
46
Corneal Scarring and Hyperopic Shift After Corneal Cross-linking for Corneal Ectasia After SMILE. 38
30428099 2018
47
[Therapeutic Options in Keratoconus]. 38
28683485 2018
48
Interface Scopulariopsis gracilis fungal keratitis following Descemet's stripping automated endothelial keratoplasty (DSAEK) with a contaminated graft. 38
28900769 2018
49
Corneal Cross-Linking: Current USA Status: Report From the Cornea Society. 38
30067537 2018
50
Outcomes of simultaneous photorefractive keratectomy and collagen crosslinking. 38
30340722 2018

Variations for Corneal Ectasia

Expression for Corneal Ectasia

Search GEO for disease gene expression data for Corneal Ectasia.

Pathways for Corneal Ectasia

GO Terms for Corneal Ectasia

Biological processes related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.62 KERA VSX1

Sources for Corneal Ectasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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