Corneal Ectasia

Categories: Eye diseases

Aliases & Classifications for Corneal Ectasia

MalaCards integrated aliases for Corneal Ectasia:

Name: Corneal Ectasia 12 15 71


External Ids:

Disease Ontology 12 DOID:1436
ICD9CM 34 371.71
SNOMED-CT 67 14748007
ICD10 32 H18.71
UMLS 71 C0155135

Summaries for Corneal Ectasia

MalaCards based summary : Corneal Ectasia is related to keratoconus 1 and astigmatism. An important gene associated with Corneal Ectasia is KERA (Keratocan). The drugs Dextrans and Plasma Substitutes have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Related Diseases for Corneal Ectasia

Diseases related to Corneal Ectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 keratoconus 1 33.0 ZNF469 VSX1
2 astigmatism 31.3 TRARG1 IFITM2 CYLC1
3 presbyopia 30.4 TRARG1 IFITM2
4 regular astigmatism 30.2 VSX1 TRARG1 CYLC1
5 corneal degeneration 29.4 VSX1 TGFBI KERA COL8A2
6 corneal edema 29.2 VSX1 TGFBI KERA CYLC1 COL8A2
7 corneal endothelial dystrophy 29.1 ZNF469 VSX1 TGFBI COL8A2
8 keratoconus 29.0 ZNF469 VSX1 TUBA3D TGFBI RAB3GAP1 MIR184
9 corneal disease 27.7 ZNF469 VSX1 TUBA3D TRARG1 TGFBI KERA
10 irregular astigmatism 26.8 ZNF469 VSX1 TRARG1 TGFBI RAB3GAP1 MIR184
11 keratoconus 9 11.5
12 myopia 10.6
13 pellucid marginal degeneration 10.4
14 accommodative esotropia 10.4 TRARG1 KERA
15 refractive error 10.4
16 accommodative spasm 10.3 IFITM2 CYLC1
17 corneal dystrophy, posterior amorphous 10.3 KERA IFITM2
18 ocular motor apraxia 10.3
19 choroid cancer 10.3 IFITM2 CYLC1
20 corneal dystrophy, posterior polymorphous, 2 10.2 VSX1 COL8A2
21 corneal dystrophy, endothelial, x-linked 10.2 VSX1 COL8A2
22 cycloplegia 10.2 IFITM2 CYLC1
23 secondary corneal edema 10.2 CYLC1 COL8A2
24 cataract 10.2
25 brittle bone disorder 10.2 ZNF469 VSX1 MIA2
26 keratitis, hereditary 10.1
27 anisometropia 10.1 TRARG1 IFITM2 CYLC1
28 eye accommodation disease 10.1 TRARG1 IFITM2 CYLC1
29 severe cutaneous adverse reaction 10.1
30 erythema multiforme 10.1
31 sclerocornea 10.1
32 keratoconjunctivitis 10.1
33 erythema multiforme major 10.1
34 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.1
35 lens disease 9.9 RAB3GAP1 CYLC1 COL8A2
36 warburg micro syndrome 9.9 ZNF469 RAB3GAP1
37 corneal dystrophy, fuchs endothelial, 1 9.9
38 ige responsiveness, atopic 9.9
39 orbital margin, hypoplasia of 9.9
40 retinal detachment 9.9
41 strabismus 9.9
42 cohen syndrome 9.9
43 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
44 familial mediterranean fever 9.9
45 macular degeneration, age-related, 1 9.9
46 pars planitis 9.9
47 keratoconus 3 9.9
48 keratoconus 2 9.9
49 keratoconus 5 9.9
50 interstitial nephritis, karyomegalic 9.9

Graphical network of the top 20 diseases related to Corneal Ectasia:

Diseases related to Corneal Ectasia

Symptoms & Phenotypes for Corneal Ectasia

Drugs & Therapeutics for Corneal Ectasia

Drugs for Corneal Ectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dextrans Phase 3
2 Plasma Substitutes Phase 3
3 Blood Substitutes Phase 3
4 Anticoagulants Phase 3
Gatifloxacin Approved, Investigational 112811-59-3 5379
Methylprednisolone Approved, Vet_approved 83-43-2 6741
Methylprednisolone hemisuccinate Approved 2921-57-5
Prednisolone Approved, Vet_approved 50-24-8 5755
9 Prednisolone acetate Approved, Vet_approved 52-21-1
Dipivefrin Approved 52365-63-6 3105
Prednisolone phosphate Approved, Vet_approved 302-25-0
Flavin Mononucleotide Approved, Investigational 146-17-8 643976
Ketotifen Approved 34580-13-7, 34580-14-8 3827
Prednisolone hemisuccinate Experimental 2920-86-7
Imidacloprid Vet_approved 105827-78-9 86418
16 Methylprednisolone Acetate
17 Anesthetics
18 Anti-Bacterial Agents
19 Antibiotics, Antitubercular
20 Mydriatics
21 Lubricant Eye Drops
22 Neurotransmitter Agents
23 Cholinergic Agents

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial Unknown status NCT01604135 Phase 3
2 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia or Progressive Keratoconus Completed NCT00567671 Phase 2, Phase 3
3 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Completed NCT00674661 Phase 3 riboflavin ophthalmic solution
4 Phase III Study of Corneal Collagen Cross-linking Using Two Different Techniques. Recruiting NCT01708538 Phase 3 CXL
5 Randomized Comparison of Standard vs. Accelerated Corneal Crosslinking for Treatment of Progressive Keratoconus or Ectasia Recruiting NCT03922542 Phase 2, Phase 3
6 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
7 Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking and Intacs for Treatment of Keratoconus and Corneal Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
8 Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin Active, not recruiting NCT01152541 Phase 3 Riboflavin/Dextran;Hypotonic Riboflavin
9 Long Term Safety and Effectiveness of the VEGA UV-A System for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Post-Refractive Corneal Ectasia Terminated NCT01398852 Phase 3 Riboflavin
10 Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
11 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
12 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Withdrawn NCT01643252 Phase 3 riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system;placebo: 0.0% riboflavin ophthalmic solution with the KXL system
13 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
14 Evaluation of Two Riboflavin Dosing Regimens for Corneal Collagen Cross-Linking in Eyes With Progressive Keratoconus or Ectasia Completed NCT01143389 Phase 2 Riboflavin
15 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia Recruiting NCT04094090 Phase 1
16 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions Recruiting NCT03918408 Phase 1
17 Evaluation of the Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions Using Peschke Riboflavin Solution Suspended NCT04177082 Phase 1
18 Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia Unknown status NCT01123057
19 Collagen Cross-linking With Riboflavin in a Hypotonic Solution, With UV Light, on Corneas Less Than 400 Microns Thick: an Exploratory Study. Unknown status NCT00890266
20 Intacs for Keratoconus Unknown status NCT00347230
21 Accelerated Versus Standard Corneal Cross Linking in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty: A Long Term Randomized Trial. Completed NCT03791684
22 Two Years Follow up of Corneal Cor Cross-linking and Refractive Surface Ablation in Patients With Asymmetric Corneal Topography Completed NCT02943967
23 Pilot Study of Excimer Laser Topography-Computer Assisted Treatment (T-Cat) Combined With Corneal Collagen Cross-linking With Riboflavin and UV Light Completed NCT00777322
24 Comparison of Corneal Stromal Tissue Consumption Values Estimated When Programming the Intervention Versus the Values Measured by Pre and Postoperative Topography Completed NCT02519673
25 Protease and Cytokine Composition in Post Lens Tear Reservoir of Scleral Lenses for Keratoconic Eyes Completed NCT02806921
26 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
27 A Phase IV Observational Registry to Assess the Safety and Durability of Effect of Corneal Collagen Cross-linking With Photrexa Viscous, Photrexa, and the KXL System in Patients With Corneal Ectasia Following Refractive Surgery Recruiting NCT03319082
28 A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia Recruiting NCT02118922
29 Corneal Elastography and Patient Specific Modeling Recruiting NCT03030755
31 A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea Recruiting NCT03220529
32 Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking Recruiting NCT03095235
33 Comparison of Clinical Outcomes of Small-incision Lenticule Extraction (SMILE) Between Different Cap Thickness. Recruiting NCT03584555
34 International Multicenter Study on Small Incision Lenticule Extraction(SMILE) Surgery Recruiting NCT02844556
35 Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus Recruiting NCT03647046
36 The Role of Anterior Segment Optical Coherence Tomography in Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking. Recruiting NCT03879421
37 Risk Assessment for Corneal Ectasia Following Laser in Situ Keratomileusis Not yet recruiting NCT03708575
38 INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia Not yet recruiting NCT02512432
39 Comparison of Anterior and Posterior Corneal Astigmatism in Patients With Keratoconus and Controls Not yet recruiting NCT03450213
40 A Specular Microscopic Study of Corneal Endothelium After Accelerated Corneal Collagen Cross Linking Not yet recruiting NCT04160338

Search NIH Clinical Center for Corneal Ectasia

Genetic Tests for Corneal Ectasia

Anatomical Context for Corneal Ectasia

MalaCards organs/tissues related to Corneal Ectasia:

Eye, Endothelial, Testes, Bone

Publications for Corneal Ectasia

Articles related to Corneal Ectasia:

(show top 50) (show all 548)
# Title Authors PMID Year
Treatment of Acute Corneal Hydrops With Combined Intracameral Gas and Approximation Sutures in Patients With Corneal Ectasia. 61
31724980 2020
Revisiting the Safety of the Corneal Collagen Crosslinking Procedure: Evaluation of the Effect of Ultraviolet A Radiation on Retinal Function and Structure. 61
31574051 2020
Corneal refractive surgery combined with simultaneous corneal cross-linking: Indications, protocols and clinical outcomes-A review. 61
31487097 2020
Comparison of Chinese and North American Tomographic Parameters and the Implications for Refractive Surgery Screening. 61
31977331 2020
Toric intraocular lens in asymmetric astigmatism. 61
31982994 2020
A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus. 61
31917136 2020
Characterization of the effect of intracorneal ring segment in corneal ectasia after laser refractive surgery. 61
30384777 2020
Modeling Changes in Corneal Parameters With Age: Implications for Corneal Disease Detection. 61
31469999 2020
A Modified Customized Rigid Gas Permeable Contact Lens to Improve Visualization During Phacoemulsification in Ectatic Corneas. 61
31976337 2020
Randomised controlled trial of corneal vs. scleral rigid gas permeable contact lenses for keratoconus and other ectatic corneal disorders. 61
31924530 2020
Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification. 61
31845757 2019
Biomechanical changes after in vivo enzyme-induced corneal crosslinking in rabbits. 61
31884496 2019
Corneal ectasia and high ametropia in an infant with microcephaly associated with presumed Zika virus congenital infection: new ocular findings. 61
31707055 2019
Effect of Sequential Intrastromal Corneal Ring Segment Implantation and Corneal Collagen Crosslinking in Corneal Ectasia. 61
31833250 2019
Corneal crosslinking: Current protocols and clinical approach. 61
31706520 2019
Invasive Pharmacology Outcomes with Different Corneal Cross-Linking Protocols: A Review. 61
31549886 2019
Outcomes of Scleral Contact Lens Use in Veteran Population. 61
31794543 2019
Review of Laser Vision Correction (LASIK, PRK and SMILE) with Simultaneous Accelerated Corneal Crosslinking - Long-term Results. 61
31411927 2019
Corneal hydrops secondary to undiagnosed keratoconus. 61
31836344 2019
Efficacy and Safety of Transglutaminase-Induced Corneal Stiffening in Rabbits. 61
31853423 2019
10-Year Results of Small Incision Lenticule Extraction. 61
31610002 2019
Posterior elevation as a risk factor for corneal ectasia after small-incision lenticule extraction. 61
31564334 2019
Contact lens fitting after corneal collagen cross-linking. 61
31902993 2019
Stromal keratophakia: Corneal inlay implantation. 61
31493488 2019
Corneal ectasia following cataract extraction surgery in a patient with keratoconus: a case report. 61
31533809 2019
The Proteins of Keratoconus: a Literature Review Exploring Their Contribution to the Pathophysiology of the Disease. 61
31363996 2019
Ten-Year Outcomes of Progressive Keratoconus Management With the Athens Protocol (Topography-Guided Partial-Refraction PRK Combined With CXL). 61
31393985 2019
Transcriptional profiling of corneal stromal cells derived from patients with keratoconus. 61
31467338 2019
Reliability of the Evidence Addressing Treatment of Corneal Diseases: A Summary of Systematic Reviews. 61
31070698 2019
Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape. 61
31316864 2019
Resolution of epithelial ingrowth after combined photorefractive keratectomy and corneal crosslinking in a patient with post-LASIK ectasia. 61
31080047 2019
Consultation Section: Refractive. Progressive corneal ectasia after LASIK in an eye that already had intrastromal corneal ring segments implantation and corneal crosslinking: June consultation #1. 61
31146939 2019
Management of Descemet Membrane's Folds After Deep Anterior Lamellar Keratoplasty: Descemet Membrane-Tucking Technique. 61
30844841 2019
To See or Not to See: A Systematic Review of the Importance of Human Ocular Surface Cytokine Biosignatures in Ocular Allergy. 61
31226821 2019
Detection of Subclinical Corneal Ectasia Using Corneal Tomographic and Biomechanical Assessments in a Japanese Population. 61
31185104 2019
False corneal ectasia in patients referred for corneal crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal rings. 61
31109479 2019
Corneal Cross-Linking: The Science Beyond the Myths and Misconceptions. 61
30882538 2019
Vernal Keratoconjunctivitis. 61
30550738 2019
Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: protocol for a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. 61
31133582 2019
Effect of the variability in implantation depth of intracorneal ring segments using the femtosecond laser technology in corneal ectasia. 61
31113256 2019
Protocol for a systematic review, meta-analysis, and trial sequential analysis of clinical outcomes following accelerated versus conventional corneal collagen cross-linking for corneal ectasia. 61
30947752 2019
Comparison of Wavefront-guided and Best Conventional Scleral Lenses after Habituation in Eyes with Corneal Ectasia. 61
30943184 2019
Long-term Outcomes of a New Surgical Technique for Corneal Remodeling in Corneal Ectasia. 61
30984984 2019
Indications and Surgical Techniques for Corneal Transplantation at a Tertiary Referral Center. 61
31114647 2019
Increased Corneal Ectasia Risk in Patients with Familial Mediterranean Fever. 61
30482054 2019
Diffuse lamellar keratitis after epi-off corneal crosslinking: An under-recognized complication? 61
30705998 2019
[The effects of corneal cross-linking on intraocular pressure measurement in keratoconus]. 61
30679128 2019
Novel dynamic corneal response parameters in a practice use: a critical review. 61
30760270 2019
Contribution of Fourier-domain optical coherence tomography to the diagnosis of keratoconus progression. 61
30367937 2019
Incidence and associations of intracorneal ring segment explantation. 61
30509748 2019

Variations for Corneal Ectasia

Expression for Corneal Ectasia

Search GEO for disease gene expression data for Corneal Ectasia.

Pathways for Corneal Ectasia

GO Terms for Corneal Ectasia

Cellular components related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 9.13 TGFBI COL8A2 COL4A3
2 extracellular matrix GO:0031012 8.92 TGFBI KERA COL8A2 COL4A3

Biological processes related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.8 KERA TGFBI VSX1

Molecular functions related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL8A2 COL4A3
2 extracellular matrix structural constituent GO:0005201 8.8 TGFBI COL8A2 COL4A3

Sources for Corneal Ectasia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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