MCID: CRN009
MIFTS: 28

Corneal Ectasia

Categories: Neuronal diseases

Aliases & Classifications for Corneal Ectasia

MalaCards integrated aliases for Corneal Ectasia:

Name: Corneal Ectasia 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1436
ICD9CM 34 371.71
SNOMED-CT 67 14748007
ICD10 32 H18.71
UMLS 71 C0155135

Summaries for Corneal Ectasia

MalaCards based summary : Corneal Ectasia is related to keratoconus 1 and astigmatism. An important gene associated with Corneal Ectasia is KERA (Keratocan). The drugs Dextrans and Plasma Substitutes have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial.

Related Diseases for Corneal Ectasia

Diseases related to Corneal Ectasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 keratoconus 1 33.0 ZNF469 VSX1
2 astigmatism 30.7 TRARG1 KRT3 IFITM2 CYLC1
3 presbyopia 30.6 TRARG1 IFITM2
4 regular astigmatism 29.9 ZNF469 VSX1 TRARG1 CYLC1
5 corneal degeneration 29.9 VSX1 KRT3 COL8A2
6 corneal endothelial dystrophy 29.6 VSX1 KRT3 COL8A2
7 corneal edema 29.5 VSX1 KRT3 KERA CYLC1 COL8A2
8 keratoconus 28.9 ZNF469 VSX1 TUBA3D RAB3GAP1 MIR184 LCN12
9 corneal disease 28.3 ZNF469 VSX1 TUBA3D KRT3 KERA IFITM2
10 irregular astigmatism 28.0 ZNF469 VSX1 TRARG1 RAB3GAP1 KRT3 KERA
11 keratoconus 9 11.5
12 joint laxity, short stature, and myopia 10.6
13 myopia 10.6
14 pellucid marginal degeneration 10.4
15 refractive error 10.4
16 accommodative esotropia 10.4 TRARG1 KERA
17 accommodative spasm 10.3 IFITM2 CYLC1
18 corneal dystrophy, posterior amorphous 10.3 KERA IFITM2
19 ocular motor apraxia 10.3
20 cataract 10.3
21 cycloplegia 10.3 IFITM2 CYLC1
22 corneal dystrophy, endothelial, x-linked 10.2 VSX1 COL8A2
23 corneal dystrophy, posterior polymorphous, 2 10.2 VSX1 COL8A2
24 secondary corneal edema 10.2 CYLC1 COL8A2
25 brittle bone disorder 10.2 ZNF469 VSX1 MIA2
26 anisometropia 10.2 TRARG1 IFITM2 CYLC1
27 eye accommodation disease 10.1 TRARG1 IFITM2 CYLC1
28 keratitis, hereditary 10.1
29 corneal dystrophy and perceptive deafness 10.1 VSX1 COL8A2
30 severe cutaneous adverse reaction 10.1
31 erythema multiforme 10.1
32 sclerocornea 10.1
33 keratoconjunctivitis 10.1
34 erythema multiforme major 10.1
35 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.1
36 punctate epithelial keratoconjunctivitis 10.0 SBK1 KRT3
37 recurrent corneal erosion 10.0 KRT3 COL8A2
38 corneal dystrophy, thiel-behnke type 9.9 KRT3 COL8A2
39 martsolf syndrome 9.9 ZNF469 RAB3GAP1
40 corneal ulcer 9.9 KRT3 KERA
41 corneal dystrophy, fuchs endothelial, 1 9.9
42 ige responsiveness, atopic 9.9
43 orbital margin, hypoplasia of 9.9
44 retinal detachment 9.9
45 strabismus 9.9
46 cohen syndrome 9.9
47 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
48 familial mediterranean fever 9.9
49 macular degeneration, age-related, 1 9.9
50 pars planitis 9.9

Graphical network of the top 20 diseases related to Corneal Ectasia:



Diseases related to Corneal Ectasia

Symptoms & Phenotypes for Corneal Ectasia

Drugs & Therapeutics for Corneal Ectasia

Drugs for Corneal Ectasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dextrans Phase 3
2 Plasma Substitutes Phase 3
3 Anticoagulants Phase 3
4 Blood Substitutes Phase 3
5
Methylprednisolone Approved, Vet_approved 83-43-2 6741
6
Gatifloxacin Approved, Investigational 112811-59-3 5379
7
Prednisolone phosphate Approved, Vet_approved 302-25-0
8
Methylprednisolone hemisuccinate Approved 2921-57-5
9
Dipivefrin Approved 52365-63-6 3105
10 Prednisolone acetate Approved, Vet_approved 52-21-1
11
Prednisolone Approved, Vet_approved 50-24-8 5755
12
Flavin Mononucleotide Approved, Investigational 146-17-8 643976
13
Ketotifen Approved 34580-13-7, 34580-14-8 3827
14
Imidacloprid Vet_approved 105827-78-9 86418
15
Prednisolone hemisuccinate Experimental 2920-86-7
16 Methylprednisolone Acetate
17 Anesthetics
18 Mydriatics
19 Anti-Bacterial Agents
20 Antibiotics, Antitubercular
21 Lubricant Eye Drops

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial Unknown status NCT01604135 Phase 3
2 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia or Progressive Keratoconus Completed NCT00567671 Phase 2, Phase 3
3 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Completed NCT00674661 Phase 3 riboflavin ophthalmic solution
4 Phase III Study of Corneal Collagen Cross-linking Using Two Different Techniques. Recruiting NCT01708538 Phase 3 CXL
5 Randomized Comparison of Standard vs. Accelerated Corneal Crosslinking for Treatment of Progressive Keratoconus or Ectasia Recruiting NCT03922542 Phase 2, Phase 3
6 Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking and Intacs for Treatment of Keratoconus and Corneal Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
7 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
8 Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin Active, not recruiting NCT01152541 Phase 3 Riboflavin/Dextran;Hypotonic Riboflavin
9 Long Term Safety and Effectiveness of the VEGA UV-A System for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Post-Refractive Corneal Ectasia Terminated NCT01398852 Phase 3 Riboflavin
10 Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
11 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
12 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Withdrawn NCT01643252 Phase 3 riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system;placebo: 0.0% riboflavin ophthalmic solution with the KXL system
13 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
14 Evaluation of Two Riboflavin Dosing Regimens for Corneal Collagen Cross-Linking in Eyes With Progressive Keratoconus or Ectasia Completed NCT01143389 Phase 2 Riboflavin
15 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions Recruiting NCT04401865 Phase 1, Phase 2
16 Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking With Corneal Thinning Conditions Recruiting NCT04213885 Phase 2
17 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Crosslinking in Eyes With Corneal Ectatic Conditions Not yet recruiting NCT04240457 Phase 2
18 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia Recruiting NCT04094090 Phase 1
19 Evaluation of the Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions Using Peschke Riboflavin Solution Recruiting NCT04177082 Phase 1
20 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions Recruiting NCT03918408 Phase 1
21 Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia Unknown status NCT01123057
22 Collagen Cross-linking With Riboflavin in a Hypotonic Solution, With UV Light, on Corneas Less Than 400 Microns Thick: an Exploratory Study. Unknown status NCT00890266
23 Comparison of Clinical Outcomes of Small-incision Lenticule Extraction (SMILE) Between Different Cap Thickness. Unknown status NCT03584555
24 Intacs for Keratoconus Unknown status NCT00347230
25 International Multicenter Study on Small Incision Lenticule Extraction(SMILE) Surgery Unknown status NCT02844556
26 Accelerated Versus Standard Corneal Cross Linking in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty: A Long Term Randomized Trial. Completed NCT03791684
27 CHOICE OF SUBJECTIVE OCULAR REFRACTION TECHNIQUE AND CORNEAL TOPOGRAPHY OF KERATOCONUS Completed NCT04174209
28 Two Years Follow up of Corneal Cor Cross-linking and Refractive Surface Ablation in Patients With Asymmetric Corneal Topography Completed NCT02943967
29 Pilot Study of Excimer Laser Topography-Computer Assisted Treatment (T-Cat) Combined With Corneal Collagen Cross-linking With Riboflavin and UV Light Completed NCT00777322
30 Combined Technique of Corneal Remodeling to Treat Ectasia Completed NCT04405882
31 Comparison of Corneal Stromal Tissue Consumption Values Estimated When Programming the Intervention Versus the Values Measured by Pre and Postoperative Topography Completed NCT02519673
32 Protease and Cytokine Composition in Post Lens Tear Reservoir of Scleral Lenses for Keratoconic Eyes Completed NCT02806921
33 Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus Completed NCT03647046
34 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
35 A Phase IV Observational Registry to Assess the Safety and Durability of Effect of Corneal Collagen Cross-linking With Photrexa Viscous, Photrexa, and the KXL System in Patients With Corneal Ectasia Following Refractive Surgery Recruiting NCT03319082
36 A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia Recruiting NCT02118922
37 Dresden Corneal Disease and Treatment Study - Analysis for Quality Inspection of Follow-up and Treatment Procedures of Corneal Diseases of the Department of Ophthalmology (University Hospital Carl Gustav Carus Dresden) Recruiting NCT04251143
38 Assessment of the Lived Experience of the Disease of the Patients Followed at the CHU of Gui de Chauliac for a Keratoconus and Their Habit of Eye Rubbing Recruiting NCT04249180
39 Corneal Elastography and Patient Specific Modeling Recruiting NCT03030755
40 A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea Recruiting NCT03220529
41 Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking Recruiting NCT03095235
42 The Role of Anterior Segment Optical Coherence Tomography in Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking. Recruiting NCT03879421
43 Risk Assessment for Corneal Ectasia Following Laser in Situ Keratomileusis Not yet recruiting NCT03708575
44 INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia Not yet recruiting NCT02512432
45 Comparison of Anterior and Posterior Corneal Astigmatism in Patients With Keratoconus and Controls Not yet recruiting NCT03450213
46 A Specular Microscopic Study of Corneal Endothelium After Accelerated Corneal Collagen Cross Linking Not yet recruiting NCT04160338

Search NIH Clinical Center for Corneal Ectasia

Genetic Tests for Corneal Ectasia

Anatomical Context for Corneal Ectasia

MalaCards organs/tissues related to Corneal Ectasia:

40
Eye, Testes, Endothelial

Publications for Corneal Ectasia

Articles related to Corneal Ectasia:

(show top 50) (show all 561)
# Title Authors PMID Year
1
Intra corneal ring segment implantation with lenticule assisted stromal augmentation for crosslinking in thin corneas. 61
32566797 2020
2
Risk factors for postlaser refractive surgery corneal ectasia. 61
32398416 2020
3
Advanced Surface Ablation in Mild (Fruste) Keratoconus: A Case Report. 61
32323165 2020
4
Corneal collagen cross-linking for bacterial infectious keratitis. 61
32557558 2020
5
Intracorneal ring segments followed by toric pseudoaccomodating IOL for treatment of patients with corneal ectasia and cataract. 61
32368687 2020
6
Ten years experience of corneal collagen cross-linking: An observational study of 6120 cases. 61
32498548 2020
7
Update on Intraocular Lens Formulas and Calculations. 61
32501896 2020
8
Toric intraocular lens in asymmetric astigmatism. 61
31982994 2020
9
Impact of Scleral Contact Lens Use on the Rate of Corneal Transplantation for Keratoconus. 61
32452985 2020
10
Corneal hydrops secondary to undiagnosed keratoconus. 61
31836344 2020
11
Genetic and Environmental Risk Factors for Keratoconus. 61
32320633 2020
12
Atypical Corneal Ectasia Associated With Vitamin C Deficiency. 61
32301811 2020
13
Stromal keratophakia: Corneal inlay implantation. 61
31493488 2020
14
The Role of Corneal Biomechanics for the Evaluation of Ectasia Patients. 61
32209975 2020
15
Comparison of Chinese and North American Tomographic Parameters and the Implications for Refractive Surgery Screening. 61
31977331 2020
16
Revisiting the Safety of the Corneal Collagen Crosslinking Procedure: Evaluation of the Effect of Ultraviolet A Radiation on Retinal Function and Structure. 61
31574051 2020
17
Treatment of Acute Corneal Hydrops With Combined Intracameral Gas and Approximation Sutures in Patients With Corneal Ectasia. 61
31724980 2020
18
Randomised controlled trial of corneal vs. scleral rigid gas permeable contact lenses for keratoconus and other ectatic corneal disorders. 61
31924530 2020
19
Corneal refractive surgery combined with simultaneous corneal cross-linking: Indications, protocols and clinical outcomes-A review. 61
31487097 2020
20
[Ultraviolet crosslinking in the treatment of keratoconus in patients with thin corneas]. 61
32366077 2020
21
A Modified Customized Rigid Gas Permeable Contact Lens to Improve Visualization During Phacoemulsification in Ectatic Corneas. 61
31976337 2020
22
Modeling Changes in Corneal Parameters With Age: Implications for Corneal Disease Detection. 61
31469999 2020
23
Transient corneal ectasia after phacoemulsification in an eye with femtosecond intrastromal presbyopic treatment. 61
32050244 2020
24
Characterization of the effect of intracorneal ring segment in corneal ectasia after laser refractive surgery. 61
30384777 2020
25
A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus. 61
31917136 2020
26
Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification. 61
31845757 2019
27
Effect of Sequential Intrastromal Corneal Ring Segment Implantation and Corneal Collagen Crosslinking in Corneal Ectasia. 61
31833250 2019
28
Biomechanical changes after in vivo enzyme-induced corneal crosslinking in rabbits. 61
31884496 2019
29
Corneal ectasia and high ametropia in an infant with microcephaly associated with presumed Zika virus congenital infection: new ocular findings. 61
31707055 2019
30
Corneal crosslinking: Current protocols and clinical approach. 61
31706520 2019
31
Invasive Pharmacology Outcomes with Different Corneal Cross-Linking Protocols: A Review. 61
31549886 2019
32
Outcomes of Scleral Contact Lens Use in Veteran Population. 61
31794543 2019
33
Review of Laser Vision Correction (LASIK, PRK and SMILE) with Simultaneous Accelerated Corneal Crosslinking - Long-term Results. 61
31411927 2019
34
Efficacy and Safety of Transglutaminase-Induced Corneal Stiffening in Rabbits. 61
31853423 2019
35
10-Year Results of Small Incision Lenticule Extraction. 61
31610002 2019
36
Posterior elevation as a risk factor for corneal ectasia after small-incision lenticule extraction. 61
31564334 2019
37
Contact lens fitting after corneal collagen cross-linking. 61
31902993 2019
38
Corneal ectasia following cataract extraction surgery in a patient with keratoconus: a case report. 61
31533809 2019
39
The Proteins of Keratoconus: a Literature Review Exploring Their Contribution to the Pathophysiology of the Disease. 61
31363996 2019
40
Transcriptional profiling of corneal stromal cells derived from patients with keratoconus. 61
31467338 2019
41
Ten-Year Outcomes of Progressive Keratoconus Management With the Athens Protocol (Topography-Guided Partial-Refraction PRK Combined With CXL). 61
31393985 2019
42
Resolution of epithelial ingrowth after combined photorefractive keratectomy and corneal crosslinking in a patient with post-LASIK ectasia. 61
31080047 2019
43
Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape. 61
31316864 2019
44
Reliability of the Evidence Addressing Treatment of Corneal Diseases: A Summary of Systematic Reviews. 61
31070698 2019
45
False corneal ectasia in patients referred for corneal crosslinking, topography-guided photorefractive keratectomy, and intrastromal corneal rings. 61
31109479 2019
46
Corneal Cross-Linking: The Science Beyond the Myths and Misconceptions. 61
30882538 2019
47
Consultation Section: Refractive. Progressive corneal ectasia after LASIK in an eye that already had intrastromal corneal ring segments implantation and corneal crosslinking: June consultation #1. 61
31146939 2019
48
Detection of Subclinical Corneal Ectasia Using Corneal Tomographic and Biomechanical Assessments in a Japanese Population. 61
31185104 2019
49
Management of Descemet Membrane's Folds After Deep Anterior Lamellar Keratoplasty: Descemet Membrane-Tucking Technique. 61
30844841 2019
50
To See or Not to See: A Systematic Review of the Importance of Human Ocular Surface Cytokine Biosignatures in Ocular Allergy. 61
31226821 2019

Variations for Corneal Ectasia

Expression for Corneal Ectasia

Search GEO for disease gene expression data for Corneal Ectasia.

Pathways for Corneal Ectasia

GO Terms for Corneal Ectasia

Molecular functions related to Corneal Ectasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL8A2 COL4A3

Sources for Corneal Ectasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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