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MCID: CRN026
MIFTS: 42

Corneal Edema

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Corneal Edema

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MalaCards integrated aliases for Corneal Edema:

Name: Corneal Edema 12 44 15 17 71
Corneal Oedema 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11030
ICD9CM 34 371.2
MeSH 44 D015715
NCIt 50 C50508
SNOMED-CT 67 193811006
ICD10 32 H18.20
UMLS 71 C0010037
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Summaries for Corneal Edema

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MalaCards based summary : Corneal Edema, also known as corneal oedema, is related to secondary corneal edema and glaucoma 3, primary congenital, a, and has symptoms including edema and swelling of eye. An important gene associated with Corneal Edema is CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Photodynamic therapy-induced NF-kB survival signaling. The drugs Hyaluronic acid and Difluprednate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and retina, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Corneal Edema

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Diseases in the Corneal Edema family:

Secondary Corneal Edema

Diseases related to Corneal Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 secondary corneal edema 32.3 SLC4A11 LOXHD1 COL8A2
2 glaucoma 3, primary congenital, a 32.0 TEK MYOC LTBP2 CYP1B1
3 glaucoma 1, open angle, a 32.0 MYOC CYP1B1
4 primary congenital glaucoma 31.9 TEK MYOC LTBP2 CYP1B1
5 cogan-reese syndrome 31.8 SLC4A11 OVOL2
6 corneal dystrophy, posterior polymorphous, 4 31.6 OVOL2 GRHL2
7 corneal dystrophy and perceptive deafness 31.1 VSX1 SLC4A11 LOXHD1 COL8A2 AQP1
8 corneal dystrophy, posterior polymorphous, 1 30.9 VSX1 SLC4A11 OVOL2 LOXHD1 KRT3 GRHL2
9 intraocular pressure quantitative trait locus 30.4 MYOC MMP1 LTBP2 CYP1B1 AQP1
10 keratitis, hereditary 30.4 MYOC KRT3 KERA IL1B CYP1B1
11 glaucoma, primary open angle 30.3 MYOC LTBP2 CYP1B1 COL8A2
12 acute closed-angle glaucoma 30.2 MYOC CYP1B1
13 recurrent corneal erosion 30.2 KRT3 IL1B COL8A2
14 exfoliation syndrome 30.0 MMP3 MMP1 LTBP2
15 fuchs' endothelial dystrophy 30.0 VSX1 TJP1 SLC4A11 PBK LOXHD1 KRT3
16 peters-plus syndrome 29.9 SLC4A11 MYOC LTBP2 CYP1B1
17 keratoconus 29.7 VSX1 SLC4A11 MMP3 MMP1 KRT3 KERA
18 corneal ectasia 29.6 VSX1 KRT3 KERA COL8A2
19 open-angle glaucoma 29.6 MYOC MMP1 LTBP2 IL1B CYP1B1 COL8A2
20 irregular astigmatism 29.4 VSX1 SLC4A11 KRT3 KERA COL8A2
21 corneal disease 29.2 VSX1 SLC4A11 LOXHD1 KRT3 KERA IL1B
22 corneal dystrophy 28.6 VSX1 TJP1 SLC4A11 OVOL2 LOXHD1 KRT3
23 corneal endothelial dystrophy 28.5 VSX1 TJP1 SLC4A11 OVOL2 LOXHD1 KRT3
24 idiopathic corneal edema 11.3
25 contact lens corneal edema 11.2
26 iridocorneal endothelial syndrome 11.0
27 essential iris atrophy 11.0
28 microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma 11.0
29 glaucoma 3, primary congenital, d 11.0
30 corneal dystrophy, fuchs endothelial, 4 11.0
31 corneal dystrophy, fuchs endothelial, 5 11.0
32 corneal dystrophy, fuchs endothelial, 6 11.0
33 corneal dystrophy, fuchs endothelial, 8 11.0
34 glaucoma 3, primary congenital, e 11.0
35 cataract 10.6
36 keratopathy 10.4
37 bullous keratopathy 10.4
38 early-onset glaucoma 10.4 MYOC CYP1B1
39 superior limbic keratoconjunctivitis 10.4 MMP3 MMP1
40 posterior corneal dystrophy 10.4 GRHL2 COL8A2
41 coronary artery aneurysm 10.3 MMP3 MMP1
42 spastic entropion 10.3 MMP3 MMP1
43 traumatic glaucoma 10.3 MYOC LTBP2 CYP1B1
44 excessive tearing 10.3 MYOC LTBP2 CYP1B1
45 hydrophthalmos 10.3 MYOC LTBP2 CYP1B1
46 periodontitis, chronic 10.3 MMP1 IL1B
47 macular retinal edema 10.3
48 glaucoma 3, primary infantile, b 10.3 TEK LTBP2 CYP1B1
49 megalocornea 10.3 MYOC LTBP2 CYP1B1
50 tendinopathy 10.3 MMP3 MMP1

Comorbidity relations with Corneal Edema via Phenotypic Disease Network (PDN):


Bullous Keratopathy Corneal Endothelial Dystrophy

Graphical network of the top 20 diseases related to Corneal Edema:



Diseases related to Corneal Edema
Sources

Symptoms & Phenotypes for Corneal Edema

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UMLS symptoms related to Corneal Edema:


edema, swelling of eye

GenomeRNAi Phenotypes related to Corneal Edema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.74 MMP3
2 Decreased viability GR00055-A-2 9.74 MMP3
3 Decreased viability GR00221-A-3 9.74 PBK TEK
4 Decreased viability GR00221-A-4 9.74 PBK
5 Decreased viability GR00249-S 9.74 CYP1B1 IL1B LTBP2 MMP3
6 Decreased viability GR00342-S-1 9.74 PBK
7 Decreased viability GR00381-A-1 9.74 AQP1 GPATCH3 GRHL2 LOXHD1 MYOC OVOL2
8 Decreased viability GR00386-A-1 9.74 AGBL1 IL1B KERA SLC4A11
9 Decreased viability GR00402-S-2 9.74 AQP1 KRT3 LOXHD1 LTBP2 OVOL2 TEK

MGI Mouse Phenotypes related to Corneal Edema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.4 AGBL1 AQP1 COL8A2 CYP1B1 GRHL2 KERA
Sources

Drugs & Therapeutics for Corneal Edema

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Drugs for Corneal Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Difluprednate Approved Phase 4 23674-86-4 443936
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
9
Loteprednol Approved, Experimental Phase 4 129260-79-3, 82034-46-6 444025 9865442
10
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
13
Polymyxin B Approved, Vet_approved Phase 4 1404-26-8
14
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
15 Anti-Infective Agents Phase 4
16 Anti-Infective Agents, Local Phase 4
17 Benzalkonium Compounds Phase 4
18 Viscosupplements Phase 4
19 Immunologic Factors Phase 4
20 Adjuvants, Immunologic Phase 4
21 Anti-Allergic Agents Phase 4
22 Ophthalmic Solutions Phase 4
23 Pharmaceutical Solutions Phase 4
24 Protective Agents Phase 4
25 Gastrointestinal Agents Phase 4
26 Anti-Inflammatory Agents Phase 4
27 Hormone Antagonists Phase 4
28 Hormones Phase 4
29 glucocorticoids Phase 4
30 BB 1101 Phase 4
31 Methylprednisolone Acetate Phase 4
32 Neuroprotective Agents Phase 4
33 Antineoplastic Agents, Hormonal Phase 4
34 Antiemetics Phase 4
35 Norgestimate, ethinyl estradiol drug combination Phase 4
36
Timolol Approved Phase 3 26839-75-8 33624 5478
37
Maleic acid Experimental Phase 3 110-16-7 444266
38 Adrenergic Antagonists Phase 3
39 Anti-Arrhythmia Agents Phase 3
40 Adrenergic beta-Antagonists Phase 3
41 Adrenergic alpha-Agonists Phase 3
42 Adrenergic Agents Phase 3
43 Adrenergic Agonists Phase 3
44 Antihypertensive Agents Phase 3
45 Brimonidine Tartrate Phase 3 70359-46-5
46 Neurotransmitter Agents Phase 3
47 Anesthetics Phase 2
48
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved 83-88-5 493570
49 Antibiotics, Antitubercular
50 Anti-Bacterial Agents

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Efficacy and Tolerability of Preservative-free 0.0015% Tafluprost in Glaucoma Patients Completed NCT03104621 Phase 4 Benzalkonium chloride (BAK);0.0015% tafluprost
2 Intraindividual Randomized Clinical Comparison of DisCoVisc and Hydroxypropylmethylcellulose 2% in Phacoemulsification Completed NCT01387620 Phase 4 Hyaluronic Acid and hydroxypropylmethylcellulose
3 A Randomized, Masked Multi-center Safety & Efficacy Study of the Effects of Preoperative & Postoperative Cataract Surgery Use of Difluprednate Ophthalmic Emulsion, 0.05% Compared to Prednisolone Acetate Ophthalmic Suspension 1% on Visual Acuity & Corneal Edema. Completed NCT01244334 Phase 4 Difluprednate ophthalmic emulsion 0.05%;Prednisolone acetate 1%
4 Prospective, Randomized Comparison of Corticosteroid Dosing Regimens Following Endothelial Keratoplasty Completed NCT01853696 Phase 4 loteprednol etabonate;prednisolone acetate 1%
5 Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt in Conjunction With Topical Prednisolone Acetate 1% Treating Pain, and inflamMation Following Corneal Transplant Surgery Compared to Topical Prednisolone Acetate 1%. Recruiting NCT04521140 Phase 4 Dextenza 0.4Mg Ophthalmic Insert;Prednisolone Acetate 1% Oph Susp
6 A Pilot Study For Efficacy And Safety Of Glanatec® Opthalmic Solution 0.4% On Corneal Edema And Endothelial Cell Counts In Subjects With Fuchs Endothelial Dystrophy Undergoing Descemet Stripping Without Endothelial Keratoplasty Recruiting NCT03249337 Phase 4 Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
7 Phase 3 Study of Brimonidine Tartrate Drops Efficacy in Reducing Post Operative Corneal Edema After Cataract Surgery Unknown status NCT00800423 Phase 3 Brimonidine Tartrate 0.2%;Timolol maleate 0.5%
8 Prospective Randomized Study to Determine Whether Use of Rhopressaâ„¢ Can Ameliorate Corneal Edema Associated With Fuchs Dystrophy Completed NCT04051463 Phase 2, Phase 3 Netarsudil Ophthalmic Solution;Placebo
9 PART A: A PROSPECTIVE, RANDOMIZED, DOUBLE-MASKED, VEHICLE CONTROLLED, PAIRED-EYE PHASE 1/2 CLINICAL STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND EFFICACY OF ELAMIPRETIDE TOPICAL OPHTHALMIC SOLUTION IN SUBJECTS WITH FCED PRESENTING WITH MILD TO MODERATE CORNEAL EDEMA PART B: A PROSPECTIVE, RANDOMIZED, DOUBLE-MASKED, VEHICLE CONTROLLED, PHASE 1/2 CLINICAL STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND EFFICACY OF ELAMIPRETIDE TOPICAL OPHTHALMIC SOLUTION IN SUBJECTS WITH FCED PRESENTING WITH MILD TO MODERATE CORNEAL EDEMA Completed NCT02653391 Phase 1, Phase 2 Elamipretide 1.0% Ophthalmic Solution;Elamipretide 3.0% Ophthalmic Solution
10 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
11 A Randomized, Open-Label, Parallel-Group Study to Evaluate the Safety and Efficacy of Two Dosing Regimens of Netarsudil Ophthalmic Solution in Patients With Corneal Edema Due to Fuchs Corneal Dystrophy Recruiting NCT04498169 Phase 2 Netarsudil Ophthalmic;Netarsudil Ophthalmic
12 Phase 1 Clinical Study to Evaluate Safety and Tolerability of Magnetic Human Corneal Endothelial Cells in the Treatment of Corneal Edema Recruiting NCT04191629 Phase 1
13 Prospective, Randomized Crossover Study Of The Hyper-CLâ„¢ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
14 ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy Completed NCT02332109
15 Prospective, Randomized Crossover Study of Using the Hyper-CLâ„¢ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
16 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) in Patients With Corneal Endothelial Cell Dysfunction: Clinical Outcomes and Diagnostic Imaging Analysis Completed NCT00744796
17 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
18 Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results Completed NCT03450954
19 Deep Lamellar Endothelial Keratoplasty as Surgical Treatment for Corneal Endothelial Decompensation Completed NCT00346138
20 Cornea Donor Study: The Effect of Donor Age on Penetrating Keratoplasty for Endothelial Disease Completed NCT00006411
21 Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking Completed NCT01106274
22 The Variation of the Intraocular Pressure Measured by Different Tonometers in Patients With Clinical Corneal Edema Completed NCT01998568
23 Amniotic Membrane and Anterior Stromal Puncture: a Comparative Study in the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
24 A Prospective, Randomized, Single Center Study Evaluating Use of Surgeon- and Eye Bank-prepared Donor Tissue for Descemet's Stripping and Endothelial Keratoplasty, a Type of Cornea Transplant Completed NCT00624221
25 Liquefaction Versus Torsional ip. A Comparative Study on Endothelial Cells, Corneal Edema and Corneal Sensitivity Completed NCT01480557
26 Efficacy of Hyperosmolar Eye Drops in Diurnal Corneal Edema in Fuchs Endothelial Dystrophy: a Double Blind Randomized Controlled Trial Completed NCT04140422
27 Descemet Membrane Endothelial Keratoplasty Combined With Intraocular Lens Exchange: Sequential Versus Combined Surgery Recruiting NCT04344522
28 Prospective, Feasibility Study to Evaluate the Safety of the EndoArtâ„¢ for Treatment of Subjects Suffering From Corneal Edema Recruiting NCT03069521
29 Evaluating Corneal Edema in Fuchs' Endothelial Dystrophy Using Optical Coherence Tomography Recruiting NCT04258787
30 Unicentric Clinical Trial on the Clinical Efficacy and Tolerance of the Treatment With an Ophthalmic Solution of Hypertonic Sodium Chloride (NaCl 5%) Without Preservatives in Patients Suffering From Symptomatic Corneal Edema Not yet recruiting NCT04125394

Search NIH Clinical Center for Corneal Edema

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Sodium Chloride
SODIUM CHLORIDE 0.9% PROCESSING SOLN
SODIUM CHLORIDE GRANULES

Cochrane evidence based reviews: corneal edema

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Genetic Tests for Corneal Edema

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Anatomical Context for Corneal Edema

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MalaCards organs/tissues related to Corneal Edema:

40
Endothelial, Eye, Retina, Brain, Cortex, Kidney, Salivary Gland
Sources

Publications for Corneal Edema

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Articles related to Corneal Edema:

(show top 50) (show all 2844)
# Title Authors PMID Year
1
Comparison of the iCare, Tono-Pen, non-contact airpuff, and Goldmann applanation tonometers in eyes with corneal edema after penetrating keratoplasty. 61
33587519 2021
2
Gender medicine in corneal transplantation: influence of sex mismatch on rejection episodes and graft survival in a prospective cohort of patients. 61
32935191 2021
3
Fluid reservoir thickness and corneal oedema during closed eye scleral lens wear: Experimental and theoretical outcomes. 61
33109472 2021
4
Eye patching after cataract surgery is associated with an increased risk of short-term corneal oedema. 61
32567237 2021
5
Fluid reservoir thickness and corneal oedema during closed eye scleral lens wear. 61
32828691 2021
6
Letter to the Editor: "Fluid reservoir thickness and corneal oedema during closed eye scleral lens wear," by Damien Fisher, Michael J. Collins, and Stephen J. Vincent. 61
33153900 2021
7
Real-time intraoperative ultrasound biomicroscopy for determining graft orientation during Descemet's membrane endothelial keratoplasty. 61
32578923 2021
8
Rho kinase (ROCK) inhibitors in the management of corneal endothelial disease. 61
33606407 2021
9
Contact lens complications among wearers in Ghana. 61
31784334 2021
10
Cytomegalovirus endotheliitis with recurrent anterior uveitis and secondary glaucoma misdiagnosed as HLA-B27 uveitis. 61
33608341 2021
11
Predicting Edema Resolution After Descemet Membrane Endothelial Keratoplasty for Fuchs Dystrophy Using Scheimpflug Tomography. 61
33599696 2021
12
Effectiveness of Pulmonary Surfactant in the Treatment of Corneal Edema. 61
33555974 2021
13
Acute corneal edema decades after penetrating keratoplasty for keratoconus in eyes wearing scleral contact lenses. 61
33160831 2021
14
Lying down looking down test: Evaluating patient suitability for small incision cataract surgery using assisted topical anesthesia. 61
33463571 2021
15
Presumed herpes simplex virus endotheliitis following ultra-thin Descemet's stripping automated endothelial keratoplasty. 61
33463607 2021
16
A refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wear. 61
33589396 2021
17
Y-27632 Promotes the Repair Effect of Umbilical Cord Blood-Derived Endothelial Progenitor Cells on Corneal Endothelial Wound Healing. 61
33086282 2021
18
Endoscopic visualization-assisted corneal bee sting removal. 61
33463602 2021
19
Pediatric Descemet's Membrane Endothelial Keratoplasty. 61
33587900 2021
20
Random Survival Forests Analysis of Intraoperative Complications as Predictors of Descemet Stripping Automated Endothelial Keratoplasty Graft Failure in the Cornea Preservation Time Study. 61
33355637 2021
21
Nonclearing Corneal Edema After Phacoemulsification and Intraocular Lens Implantation. 61
33570550 2021
22
Interface Fluid Syndrome 2 Decades After Laser-Assisted In situ Keratomileusis. 61
33560744 2021
23
[Development in the diagnosis and treatment of Descemet's membrane detachment]. 61
33541057 2021
24
Different Innate Immune Responses in BALB/c and C57BL/6 Strains following Corneal Transplantation. 61
32906119 2021
25
Management of cytomegalovirus corneal endotheliitis. 61
33441165 2021
26
Acute angle-closure glaucoma with choroidal effusion revealing a hantavirus infection: Description of ultrasound biomicroscopy imagery and optical coherence tomography Visante. 61
31256684 2021
27
Anterior Segment Ischemia After Peripheral Annular Lamellar Sclerokeratoplasty for Advanced Terrien Marginal Degeneration. 61
33399413 2021
28
Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema. 61
33470681 2021
29
Open-Source Automatic Segmentation of Ocular Structures and Biomarkers of Microbial Keratitis on Slit-Lamp Photography Images Using Deep Learning. 61
32248131 2021
30
Comparison of the effect of teicoplanin and vancomycin on experimental methicillin-resistant staphylococcus aureus keratitis. 61
33506369 2021
31
Identification and molecular characterization of Subramaniula asteroides causing human fungal keratitis: a case report. 61
33461505 2021
32
Risk Factors for Repeat Keratoplasty after Endothelial Keratoplasty in the Medicare Population. 61
32791066 2021
33
[Explantation of the CyPass implant in a case series of patients with corneal decompensation]. 61
32350610 2021
34
A novel intraocular lens designed for sutureless scleral fixation: surgical series. 61
32529278 2021
35
Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis. 61
32438095 2021
36
A Case Report Illustrating the Spontaneous Vision Recovery After Inadvertent Central Descemetorhexis During Anterior Capsulotomy. 61
33568952 2021
37
Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes. 61
33497768 2021
38
Case Series: Novel Utilization of Rho-Kinase Inhibitor for the Treatment of Corneal Edema. 61
33269892 2021
39
Complications of Cosmetic Artificial Iris Implantation and Post Explantation Outcomes. 61
33493470 2021
40
Ultramarathon-induced Corneal Edema-A Case Report. 61
33395125 2021
41
Cataract surgery in surgical camps: outcomes in a rural area of Cameroon. 61
32979111 2021
42
Full- versus partial-thickness sutures: experimental models of corneal injury repair. 61
32915390 2021
43
Atypical Case of Bilateral Chandler Syndrome With Recurrent Band Keratopathy. 61
33264150 2020
44
Occlusion of AquaPORT Flow in a Case of Toxic Anterior Segment Syndrome Following Implantable Collamer Lens Surgery Causing Severe Pupillary Block. 61
33296000 2020
45
Accelerated corneal endothelial cell loss in two patients with granulomatosis with polyangiitis following phacoemulsification. 61
33287743 2020
46
Case Report: Use of Prosthetic Replacement of the Ocular Surface Ecosystem Treatment of Traumatic Lid Ptosis in a Pediatric Patient. 61
33259377 2020
47
Clinical manifestations of intravitreal bortezomib injection. 61
33163689 2020
48
Surgical intervention for dynamic movement of a glaucoma drainage device with shifting tube position associated with corneal edema and cataract. 61
33102930 2020
49
"Basket" mattress suture to manage positive vitreous pressure during penetrating keratoplasty. 61
32730748 2020
50
Spontaneous Descemet Membrane Detachment After Penetrating Keratoplasty-Clinical Presentation and Outcome of Air/Gas Descemetopexy. 61
32452984 2020
Sources

Variations for Corneal Edema

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Expression for Corneal Edema

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Search GEO for disease gene expression data for Corneal Edema.
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Pathways for Corneal Edema

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Pathways related to Corneal Edema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Interleukin-4 and 13 signaling 65
11.39 MMP3 MMP1 IL1B
2
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.93 MMP3 MMP1 IL1B
3
Rheumatoid arthritis 36
10.89 TEK MMP3 MMP1 IL1B
Sources

GO Terms for Corneal Edema

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Cellular components related to Corneal Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.26 TJP1 TEK SLC4A11 AQP1
2 extracellular matrix GO:0031012 9.02 MMP3 MMP1 LTBP2 KERA COL8A2

Biological processes related to Corneal Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.56 TEK OVOL2 CYP1B1 COL8A2
2 cellular response to nitric oxide GO:0071732 9.37 MMP3 AQP1
3 heart trabecula formation GO:0060347 9.32 TEK OVOL2
4 cellular response to UV-A GO:0071492 9.16 MMP3 MMP1
5 negative regulation of keratinocyte differentiation GO:0045617 8.96 OVOL2 GRHL2
6 positive regulation of angiogenesis GO:0045766 8.92 TEK IL1B CYP1B1 AQP1
Sources

Sources for Corneal Edema

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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