MCID: CRN016
MIFTS: 19

Corneal Intraepithelial Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Corneal Intraepithelial Neoplasm

MalaCards integrated aliases for Corneal Intraepithelial Neoplasm:

Name: Corneal Intraepithelial Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:6198
NCIt 49 C6093
UMLS 71 C1333159

Summaries for Corneal Intraepithelial Neoplasm

MalaCards based summary : Corneal Intraepithelial Neoplasm is related to conjunctival intraepithelial neoplasm and lymphomatoid granulomatosis. An important gene associated with Corneal Intraepithelial Neoplasm is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Allograft rejection and Pathways in cancer. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Corneal Intraepithelial Neoplasm

Diseases related to Corneal Intraepithelial Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 conjunctival intraepithelial neoplasm 10.0
2 lymphomatoid granulomatosis 9.8 IFNA2 IFNA1
3 colorectal cancer 5 9.8 IFNA2 IFNA1
4 cryoglobulinemia, familial mixed 9.8 IFNA2 IFNA1
5 cryoglobulinemia 9.8 IFNA2 IFNA1
6 discoid lupus erythematosus 9.8 IFNA2 IFNA1
7 squamous papillomatosis 9.8 IFNA2 IFNA1
8 splenomegaly 9.8 IFNA2 IFNA1
9 aggressive systemic mastocytosis 9.8 IFNA2 IFNA1
10 systemic mastocytosis 9.8 IFNA2 IFNA1
11 hepatitis d 9.8 IFNA2 IFNA1
12 hepatitis 9.8 IFNA2 IFNA1
13 peyronie's disease 9.8 IFNA2 IFNA1
14 penile disease 9.8 IFNA2 IFNA1
15 portal vein thrombosis 9.8 IFNA2 IFNA1
16 herpes zoster 9.8 IFNA2 IFNA1
17 hepatitis a 9.8 IFNA2 IFNA1
18 stomatitis 9.7 IFNA2 IFNA1
19 hairy cell leukemia 9.7 IFNA2 IFNA1
20 viral hepatitis 9.7 IFNA2 IFNA1
21 hypereosinophilic syndrome 9.7 IFNA2 IFNA1
22 mycosis fungoides 9.7 IFNA2 IFNA1
23 cutaneous t cell lymphoma 9.7 IFNA2 IFNA1
24 acquired immunodeficiency syndrome 9.7 IFNA2 IFNA1
25 polycythemia vera 9.7 IFNA2 IFNA1
26 essential thrombocythemia 9.7 IFNA2 IFNA1
27 kaposi sarcoma 9.7 IFNA2 IFNA1
28 sarcoma 9.7 IFNA2 IFNA1
29 behcet syndrome 9.7 IFNA2 IFNA1
30 myeloproliferative neoplasm 9.7 IFNA2 IFNA1
31 viral infectious disease 9.7 IFNA2 IFNA1
32 neutropenia 9.6 IFNA2 IFNA1
33 myelofibrosis 9.6 IFNA2 IFNA1
34 hepatitis b 9.6 IFNA2 IFNA1
35 hepatitis c 9.6 IFNA2 IFNA1
36 kidney cancer 9.6 IFNA2 IFNA1
37 liver cirrhosis 9.6 IFNA2 IFNA1
38 deficiency anemia 9.5 IFNA2 IFNA1
39 hypothyroidism 9.5 IFNA2 IFNA1
40 leukemia, chronic myeloid 9.4 IFNA2 IFNA1
41 thrombocytopenia 9.2 IFNA2 IFNA1

Graphical network of the top 20 diseases related to Corneal Intraepithelial Neoplasm:



Diseases related to Corneal Intraepithelial Neoplasm

Symptoms & Phenotypes for Corneal Intraepithelial Neoplasm

GenomeRNAi Phenotypes related to Corneal Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 IFNA1 IFNA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.83 IFNA1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.83 IFNA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.83 IFNA1 IFNA2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.83 IFNA1 IFNA2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.83 IFNA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.83 IFNA2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.83 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.83 IFNA1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.83 IFNA1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.83 IFNA1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.83 IFNA1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.83 IFNA1

Drugs & Therapeutics for Corneal Intraepithelial Neoplasm

Search Clinical Trials , NIH Clinical Center for Corneal Intraepithelial Neoplasm

Genetic Tests for Corneal Intraepithelial Neoplasm

Anatomical Context for Corneal Intraepithelial Neoplasm

Publications for Corneal Intraepithelial Neoplasm

Articles related to Corneal Intraepithelial Neoplasm:

# Title Authors PMID Year
1
Clinical and pathological characteristics of ocular surface squamous neoplasia in an Asian population. 61
24006080 2013
2
Conjunctival-corneal intraepithelial neoplasm in an Asian elephant (Elephas maximus). 61
17319149 2006

Variations for Corneal Intraepithelial Neoplasm

Expression for Corneal Intraepithelial Neoplasm

Search GEO for disease gene expression data for Corneal Intraepithelial Neoplasm.

Pathways for Corneal Intraepithelial Neoplasm

Pathways related to Corneal Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 IFNA2 IFNA1
2 12.28 IFNA2 IFNA1
3
Show member pathways
12.24 IFNA2 IFNA1
4 12.22 IFNA2 IFNA1
5
Show member pathways
12.18 IFNA2 IFNA1
6
Show member pathways
11.97 IFNA2 IFNA1
7
Show member pathways
11.93 IFNA2 IFNA1
8
Show member pathways
11.74 IFNA2 IFNA1
9
Show member pathways
11.7 IFNA2 IFNA1
10 11.66 IFNA2 IFNA1
11 11.62 IFNA2 IFNA1
12
Show member pathways
11.62 IFNA2 IFNA1
13
Show member pathways
11.56 IFNA2 IFNA1
14 11.35 IFNA2 IFNA1
15 10.9 IFNA2 IFNA1
16 10.26 IFNA2 IFNA1

GO Terms for Corneal Intraepithelial Neoplasm

Biological processes related to Corneal Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.52 IFNA2 IFNA1
2 cytokine-mediated signaling pathway GO:0019221 9.51 IFNA2 IFNA1
3 defense response to virus GO:0051607 9.49 IFNA2 IFNA1
4 blood coagulation GO:0007596 9.48 IFNA2 IFNA1
5 defense response GO:0006952 9.46 IFNA2 IFNA1
6 B cell differentiation GO:0030183 9.43 IFNA2 IFNA1
7 type I interferon signaling pathway GO:0060337 9.4 IFNA2 IFNA1
8 humoral immune response GO:0006959 9.37 IFNA2 IFNA1
9 B cell proliferation GO:0042100 9.32 IFNA2 IFNA1
10 response to exogenous dsRNA GO:0043330 9.26 IFNA2 IFNA1
11 T cell activation involved in immune response GO:0002286 9.16 IFNA2 IFNA1
12 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 8.96 IFNA2 IFNA1
13 natural killer cell activation involved in immune response GO:0002323 8.62 IFNA2 IFNA1

Molecular functions related to Corneal Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.16 IFNA2 IFNA1
2 cytokine receptor binding GO:0005126 8.96 IFNA2 IFNA1
3 type I interferon receptor binding GO:0005132 8.62 IFNA2 IFNA1

Sources for Corneal Intraepithelial Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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