MCID: CRN027
MIFTS: 51

Corneal Neovascularization

Categories: Eye diseases

Aliases & Classifications for Corneal Neovascularization

MalaCards integrated aliases for Corneal Neovascularization:

Name: Corneal Neovascularization 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11382
ICD9CM 36 370.6 370.60
MeSH 45 D016510
SNOMED-CT 69 19161004
ICD10 34 H16.4 H16.40
UMLS 74 C0085109

Summaries for Corneal Neovascularization

MalaCards based summary : Corneal Neovascularization is related to retinal vascular disease and warburg-cinotti syndrome. An important gene associated with Corneal Neovascularization is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Bevacizumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and brain, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 77 Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into... more...

Related Diseases for Corneal Neovascularization

Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 retinal vascular disease 29.6 FLT1 KDR PLG SERPINF1 VEGFA
2 warburg-cinotti syndrome 11.3
3 burns 10.5
4 glomeruloid hemangioma 10.4 FLT1 VEGFA
5 vitreous detachment 10.3 PLG VEGFA
6 critical limb ischemia 10.3 TEK VEGFA
7 angiodysplasia 10.3 FGF2 VEGFA
8 macular dystrophy, dominant cystoid 10.3 SERPINF1 VEGFA
9 pyogenic granuloma 10.3 TEK VEGFA
10 keratitis, hereditary 10.3
11 poems syndrome 10.3 FGF2 VEGFA
12 blood group, globoside system 10.3 PLG VEGFA
13 diabetic cataract 10.3 SERPINF1 VEGFA
14 cancer-associated retinopathy 10.3 FLT1 VEGFA
15 posterior uveal melanoma 10.2 THBS1 VEGFA
16 angiokeratoma circumscriptum 10.2 FLT1 KDR VEGFA
17 breast carcinoma in situ 10.2 FGF2 FLT1 VEGFA
18 skin hemangioma 10.2 FLT1 KDR VEGFA
19 angiomatous meningioma 10.2 FGF2 KDR VEGFA
20 epithelioid hemangioendothelioma 10.2 FLT1 KDR VEGFA
21 bursitis 10.2 CXCL12 KDR
22 vitreous disease 10.2 FGF2 PLG VEGFA
23 endophthalmitis 10.2 PLG VEGFA
24 keratopathy 10.2
25 arteries, anomalies of 10.2 FLT1 PLG VEGFA
26 kaposiform hemangioendothelioma 10.2 KDR PECAM1
27 kaposi sarcoma 10.2 FGF2 KDR VEGFA
28 placenta accreta 10.2 FLT1 KDR TEK
29 pulmonary vein stenosis 10.1 KDR PECAM1
30 limbal stem cell deficiency 10.1
31 stromal keratitis 10.1
32 clivus chordoma 10.1 CXCL12 FGF2
33 arteriovenous malformations of the brain 10.1 KDR THBS1 VEGFA
34 juvenile nasopharyngeal angiofibroma 10.1 FGF2 PECAM1 VEGFA
35 retinal vascular occlusion 10.1 PLG VEGFA
36 diabetic macular edema 10.1 FGF2 SERPINF1 TEK VEGFA
37 cavernous hemangioma 10.0 FGF2 KDR PECAM1
38 hemangioendothelioma 10.0 KDR PECAM1 PLG
39 microcystic meningioma 10.0 FLT1 TIMP2 VEGFA
40 renal cell carcinoma, nonpapillary 10.0 FGF2 FLT1 KDR VEGFA
41 chronic myocardial ischemia 10.0 FGF2 PLG TEK VEGFA
42 dupuytren contracture 10.0 FGF2 TIMP2 VEGFA
43 lipodermatosclerosis 10.0 FLT1 TIMP2 VEGFA
44 placental insufficiency 10.0 FLT1 KDR TEK VEGFA
45 exudative vitreoretinopathy 1 10.0 FLT1 KDR TEK VEGFA
46 breast disease 10.0 TEK THBS1 VEGFA
47 hydrocele 10.0 PECAM1 VEGFA
48 herpes simplex 10.0
49 hypoxia 10.0
50 large intestine cancer 10.0 CXCL12 FLT1 KDR VEGFA

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to Corneal Neovascularization

Symptoms & Phenotypes for Corneal Neovascularization

MGI Mouse Phenotypes related to Corneal Neovascularization:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 CXCL10 CXCL12 FGF2 FLT1 KDR PECAM1
2 hematopoietic system MP:0005397 10.23 CXCL10 CXCL12 FGF2 FLT1 KDR PECAM1
3 cellular MP:0005384 10.19 CXCL10 CXCL12 FGF2 FLT1 KDR PECAM1
4 homeostasis/metabolism MP:0005376 10.13 CXCL10 FGF2 FLT1 KDR PECAM1 PLG
5 immune system MP:0005387 10.1 CXCL10 CXCL12 FLT1 KDR PECAM1 PLG
6 mortality/aging MP:0010768 10.02 CXCL10 CXCL12 FGF2 FLT1 KDR PLG
7 digestive/alimentary MP:0005381 9.95 PECAM1 PLG SERPINF1 SLIT2 THBS1 VEGFA
8 nervous system MP:0003631 9.9 CXCL10 CXCL12 FGF2 FLT1 KDR PLG
9 muscle MP:0005369 9.86 CXCL12 FGF2 FLT1 KDR PECAM1 TEK
10 liver/biliary system MP:0005370 9.85 CXCL12 KDR PECAM1 PLG THBS1 VEGFA
11 reproductive system MP:0005389 9.5 CXCL12 FGF2 FLT1 PLG SERPINF1 THBS1
12 vision/eye MP:0005391 9.23 FGF2 FLT1 KDR PLG SERPINF1 TEK

Drugs & Therapeutics for Corneal Neovascularization

Drugs for Corneal Neovascularization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 216974-75-3
2 Immunoglobulins Phase 4,Phase 2,Phase 1
3 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
4 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2,Not Applicable
5 Antibodies Phase 4,Phase 2,Phase 1
6 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
7 Antineoplastic Agents, Immunological Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
8 Antibodies, Monoclonal Phase 4,Phase 2
9 Anesthetics Phase 4,Phase 2
10
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
11
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 54715139 5280972
12
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
13
Natamycin Approved Phase 3 7681-93-8 5281099
14
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
15
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1,Not Applicable 22916-47-8 4189
16 Antimalarials Phase 2, Phase 3
17 Antiparasitic Agents Phase 2, Phase 3
18 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
19 Antiprotozoal Agents Phase 2, Phase 3
20 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3,Phase 1
21 Endothelial Growth Factors Phase 2, Phase 3
22 Mitogens Phase 2, Phase 3
23 Triamcinolone hexacetonide Phase 2, Phase 3
24 Triamcinolone diacetate Phase 2, Phase 3
25 triamcinolone acetonide Phase 2, Phase 3
26 Steroid Synthesis Inhibitors Phase 3
27 Hormone Antagonists Phase 3,Not Applicable
28 Antifungal Agents Phase 3,Phase 1,Not Applicable
29 Cytochrome P-450 CYP3A Inhibitors Phase 3
30 Anti-Infective Agents, Local Phase 3
31 Cytochrome P-450 Enzyme Inhibitors Phase 3
32 Hormones Phase 3,Not Applicable
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
34 Laxatives Phase 1, Phase 2,Phase 2
35 Carboxymethylcellulose Sodium Phase 1, Phase 2,Phase 2
36 Gastrointestinal Agents Phase 1, Phase 2,Phase 2
37 Cathartics Phase 1, Phase 2,Phase 2
38 Ophthalmic Solutions Phase 1, Phase 2,Not Applicable
39 Antirheumatic Agents Phase 1, Phase 2,Not Applicable
40 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
41
Ranibizumab Approved Phase 1 347396-82-1 459903
42
Tropicamide Approved, Investigational Phase 1 1508-75-4 5593
43
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
44
Zinc Approved, Investigational Phase 1 7440-66-6 32051
45 Lubricant Eye Drops Phase 1
46 Betamethasone sodium phosphate Phase 1
47 Betamethasone benzoate Phase 1
48 Gentamicins Phase 1
49 Betamethasone-17,21-dipropionate Phase 1
50 Betamethasone Valerate Phase 1 2152-44-5

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 Strategies for Management of Corneal Neovascularisation Unknown status NCT02594423 Phase 4 Bevacizumab
2 The Effect of Bevacizumab on Corneal Neovascularization Completed NCT00797303 Phase 4 Bevacizumab
3 Comparative Performance of PureVision, Acuvue Oasys and O2Optix Completed NCT00640341 Phase 4
4 Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism Completed NCT01965288 Phase 4
5 Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency Recruiting NCT02577861 Phase 4
6 The Role of Amniotic Membrane Transplantation in Ocular Chemical Burns Unknown status NCT00370812 Phase 2, Phase 3
7 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3 Doxycycline;Placebo
8 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3 Bevacizumab (Avastin)
9 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Completed NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
10 Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency Withdrawn NCT01489501 Phase 3
11 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
12 Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization Unknown status NCT02797704 Phase 1, Phase 2 Aflibercept
13 Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose Unknown status NCT02157987 Phase 1, Phase 2 bevacuzimab spray
14 Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease Unknown status NCT03015779 Phase 1, Phase 2
15 Cell Therapy in Failure Syndromes in Limbal Stem Cells Unknown status NCT01619189 Phase 2
16 Treatment of Corneal Neovascularization With Topical Pazopanib Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
17 Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01072357 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
18 A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01996826 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
19 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
20 Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo Completed NCT01470573 Phase 2
21 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
22 Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD Recruiting NCT03549299 Phase 1, Phase 2
23 Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment Recruiting NCT01765244 Phase 1, Phase 2 Anterior lamellar nanostructured artificial human cornea.
24 Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Recruiting NCT02318485 Phase 2
25 Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases Active, not recruiting NCT02739113 Phase 1, Phase 2
26 Topical IL-1-Ra for Treatment of Corneal Neovascularization Terminated NCT00915590 Phase 1, Phase 2 Placebo;IL-1Ra
27 Topical Avastin for Treatment of Corneal Neovascularization Completed NCT00559936 Phase 1 Topical Avastin 1%
28 Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV) Completed NCT00681889 Phase 1 Ranibizumab
29 Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery Completed NCT00769145 Phase 1 Ranibizumab
30 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
31 Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
32 The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED) Completed NCT02649621 Phase 1
33 Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea Terminated NCT01868360 Phase 1 Subconjunctival aflibercept
34 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
35 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
36 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00512876 Not Applicable Bevacizumab (Avastin)
37 Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization Completed NCT00004430 Not Applicable Dihematoporphyrin derivative;prednisolone
38 Photodynamic Therapy With Verteporfin for Corneal Neovascularization Completed NCT00471406 Not Applicable
39 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 Not Applicable subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
40 Neovascularization Patterns in Corneal Graft Rejection Completed NCT01695655
41 Comparison of Subconjuctival Versus Topical Bevacizumab as Adjunct Therapy to Trabeculectomy Completed NCT01425112 Not Applicable
42 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
43 Product Performance of a Toric Contact Lens Completed NCT00658996 Not Applicable
44 A Study to Evaluate the Clinical Performance of a Novel Multipurpose Solution Completed NCT01024751 Not Applicable
45 A Study to Evaluate the Product Performance of a Daily Disposable Contact Lens Completed NCT01192126 Not Applicable
46 Vistakon Investigational Multi-purpose Contact Lens Care Solution. Completed NCT01055457 Not Applicable
47 Evaluation of a New Silicone Hydrogel Contact Lens Completed NCT01309880 Not Applicable
48 Vistakon Investigational Lens Worn as a Single Use Daily Wear Completed NCT01031004 Not Applicable
49 The Clinical and Subjective Performance of Three Different MPDS With Silicon Hydrogel Lenses Completed NCT01665612 Not Applicable
50 One Month Daily Wear Clinical Evaluation of New Prototype Contact Lenses in Habitual and Neophyte Contact Lens Wearers Completed NCT02081677 Not Applicable

Search NIH Clinical Center for Corneal Neovascularization

Cochrane evidence based reviews: corneal neovascularization

Genetic Tests for Corneal Neovascularization

Anatomical Context for Corneal Neovascularization

MalaCards organs/tissues related to Corneal Neovascularization:

42
Eye, Endothelial, Brain, Breast, Neutrophil, B Cells, Skin

Publications for Corneal Neovascularization

Articles related to Corneal Neovascularization:

(show top 50) (show all 505)
# Title Authors Year
1
Treatment of corneal neovascularization with topical aflibercept in a case of exposure keratopathy following cerebellar astrocytoma surgery. ( 30574927 )
2019
2
Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model. ( 30646013 )
2019
3
Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization. ( 30677499 )
2019
4
Efficacy of sunitinib, sunitinib-hesperetin and sunitinib-doxycycline combinations on experimentally-induced corneal neovascularization. ( 30803276 )
2019
5
Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization. ( 30816491 )
2019
6
Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography. ( 30908339 )
2019
7
Long non-coding RNA H19 promotes corneal neovascularization by targeting microRNA-29c. ( 30948500 )
2019
8
MicroRNAs in the cornea: Role and implications for treatment of corneal neovascularization. ( 30959113 )
2019
9
Regulation of Matrix Metalloproteinase 2 and 9 in Corneal Neovascularization. ( 31002472 )
2019
10
MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing. ( 31003493 )
2019
11
Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization. ( 31090470 )
2019
12
Effectiveness of photodynamic therapy with verteporfin combined with intrastromal bevacizumab for corneal neovascularization in Stevens-Johnson syndrome. ( 29256167 )
2019
13
Effect of metronidazole ophthalmic solution on corneal neovascularization in a rat model. ( 29700650 )
2019
14
Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn. ( 30551354 )
2019
15
Inhibited corneal neovascularization in rabbits following corneal alkali burn by double-target interference for VEGF and HIF-1α. ( 30355648 )
2019
16
Activation of Toll-like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF-1-mediated endothelial progenitor cell recruitment. ( 30321512 )
2019
17
Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland. ( 30574658 )
2018
18
Protective Effect of TLR4 Ablation against Corneal Neovascularization following Chemical Burn in a Mouse Model. ( 30595046 )
2018
19
MicroRNA-296 mediated corneal neovascularization in an animal model of corneal burns after alkali exposures. ( 29399058 )
2018
20
Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection. ( 28378806 )
2018
21
Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization. ( 28393322 )
2018
22
Critical Contact Lens Oxygen Transmissibility and Tear Lens Oxygen Tension to Preclude Corneal Neovascularization. ( 28799960 )
2018
23
Effects of sunitinib and bevacizumab on VEGF and miRNA levels on corneal neovascularization. ( 28874077 )
2018
24
Gene-based antiangiogenic applications for corneal neovascularization. ( 29080632 )
2018
25
Antiangiogenic effects of catalpol on rat corneal neovascularization. ( 29207076 )
2018
26
Epithelium-derived miR-204 inhibits corneal neovascularization. ( 29246498 )
2018
27
Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P2X2. ( 29265937 )
2018
28
Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization. ( 29445990 )
2018
29
Ginsenoside Rh2 inhibits vascular endothelial growth factor-induced corneal neovascularization. ( 29465315 )
2018
30
In Vivo Confocal Microscopic Study of Hard Contact Lens-Induced Lipid Keratopathy Secondary to Corneal Neovascularization in a Rabbit Hypercholesterolemic Model. ( 29489496 )
2018
31
B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model. ( 29515217 )
2018
32
Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Corneal Neovascularization in Rabbits. ( 29533953 )
2018
33
Successful single treatment with ziv-aflibercept for existing corneal neovascularization following ocular chemical insult in the rabbit model. ( 29548928 )
2018
34
Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography. ( 29625447 )
2018
35
Substance P Modulation of Human and Murine Corneal Neovascularization. ( 29625453 )
2018
36
Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2‑mediated STAT3/PI3K/Akt signaling pathway. ( 29717775 )
2018
37
Epigallocatechin gallate inhibits corneal neovascularization in ratalkaline burn model. ( 29731448 )
2018
38
A Case of Corneal Neovascularization Misdiagnosed as Total Limbal Stem Cell Deficiency. ( 29781927 )
2018
39
Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization. ( 29801148 )
2018
40
Inhibitory Effects of Glycyrrhiza glabra and Its Major Constituent Glycyrrhizin on Inflammation-Associated Corneal Neovascularization. ( 29849730 )
2018
41
Long-term outcome of using Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) as a drug delivery system for bevacizumab in the treatment of corneal neovascularization. ( 30468876 )
2018
42
Propranolol eye drops in patients with corneal neovascularization. ( 30407290 )
2018
43
Effect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in Rabbits. ( 30402279 )
2018
44
LncRNA NEAT1 promotes inflammatory response and induces corneal neovascularization ( 30328354 )
2018
45
Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography. ( 30280000 )
2018
46
The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor. ( 30254425 )
2018
47
Streptozotocin‑induced diabetic mice exhibit reduced experimental choroidal neovascularization but not corneal neovascularization. ( 30221697 )
2018
48
Prevention of corneal neovascularization by subconjunctival injection of avastin® loaded thermosensitive hydrogels in rabbit model. ( 30217769 )
2018
49
Autocrine IL-1β mediates the promotion of corneal neovascularization by senescent fibroblasts. ( 30156862 )
2018
50
Comparison of the inhibitory effect of different doses of subconjunctival bevacizumab application in an experimental model of corneal neovascularization. ( 30046522 )
2018

Variations for Corneal Neovascularization

Expression for Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for Corneal Neovascularization

Pathways related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
2
Show member pathways
13.61 CXCL12 FGF2 FLT1 KDR TEK TIMP2
3
Show member pathways
13.42 CXCL12 FGF2 FLT1 KDR TEK TIMP2
4
Show member pathways
13.31 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
5
Show member pathways
13.3 CXCL10 CXCL12 KDR PECAM1 PLG THBS1
6
Show member pathways
13.22 CXCL12 FGF2 FLT1 KDR TEK TIMP2
7
Show member pathways
13.21 HRG PECAM1 PLG TEK THBS1 VEGFA
8
Show member pathways
13.17 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
9
Show member pathways
13.12 CXCL12 FGF2 FLT1 KDR TEK TIMP2
10
Show member pathways
12.96 CXCL12 FGF2 FLT1 KDR TIMP2
11
Show member pathways
12.95 CXCL12 FGF2 FLT1 KDR TIMP2
12
Show member pathways
12.86 FGF2 FLT1 KDR TEK THBS1 VEGFA
13 12.68 FGF2 FLT1 KDR TEK VEGFA
14
Show member pathways
12.62 CXCL12 FGF2 FLT1 KDR TIMP2
15
Show member pathways
12.59 FGF2 KDR PECAM1 PLG THBS1 TIMP2
16
Show member pathways
12.56 CXCL12 KDR PECAM1 VEGFA
17
Show member pathways
12.55 FGF2 FLT1 KDR TEK THBS1 VEGFA
18
Show member pathways
12.31 FGF2 FLT1 KDR VEGFA
19
Show member pathways
12.25 CXCL12 FGF2 FLT1 KDR TEK TIMP2
20 12.23 FGF2 KDR THBS1 VEGFA
21
Show member pathways
12.15 FGF2 FLT1 KDR VEGFA
22
Show member pathways
12.12 CXCL12 FGF2 FLT1 KDR TIMP2
23
Show member pathways
12.05 KDR PECAM1 THBS1
24 12.04 FGF2 FLT1 KDR TEK
25 12 KDR PECAM1 VEGFA
26
Show member pathways
11.99 CXCL12 FGF2 FLT1 KDR TIMP2
27 11.98 FGF2 KDR VEGFA
28 11.95 FLT1 KDR VEGFA
29
Show member pathways
11.9 FLT1 KDR VEGFA
30 11.82 FLT1 TEK VEGFA
31
Show member pathways
11.78 FLT1 KDR VEGFA
32 11.75 CXCL12 FLT1 TEK VEGFA
33 11.6 FLT1 KDR VEGFA
34 11.45 FGF2 FLT1 KDR PECAM1 TEK THBS1
35 11.44 FGF2 KDR VEGFA
36 11.4 FGF2 KDR PLG VEGFA
37 11.3 FGF2 FLT1 KDR VEGFA
38 11.24 FLT1 KDR VEGFA
39 11.05 CXCL12 FGF2 PLG THBS1
40 11.03 FGF2 FLT1 KDR VEGFA
41 10.87 FGF2 FLT1 SLIT2 VEGFA
42 10.77 HRG PLG
43 10.77 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
44 10.48 FGF2 FLT1 KDR TEK TIMP2 VEGFA

GO Terms for Corneal Neovascularization

Cellular components related to Corneal Neovascularization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.95 CXCL12 HRG PECAM1 PLG SERPINF1 SLIT2
2 cell surface GO:0009986 9.8 HRG PLG TEK THBS1 TIMP2 VEGFA
3 extracellular space GO:0005615 9.7 CXCL10 CXCL12 FGF2 FLT1 PECAM1 PLG
4 external side of plasma membrane GO:0009897 9.67 CXCL10 CXCL12 PECAM1 THBS1
5 collagen-containing extracellular matrix GO:0062023 9.65 HRG PLG SERPINF1 THBS1 TIMP2
6 platelet alpha granule lumen GO:0031093 9.46 HRG PLG THBS1 VEGFA
7 extracellular region GO:0005576 9.44 CXCL10 CXCL12 FGF2 FLT1 HRG KDR

Biological processes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 KDR TEK THBS1 VEGFA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 FGF2 FLT1 KDR TEK
3 extracellular matrix organization GO:0030198 9.93 FGF2 KDR PECAM1 THBS1
4 response to hypoxia GO:0001666 9.91 CXCL12 TEK THBS1 VEGFA
5 protein autophosphorylation GO:0046777 9.88 FLT1 KDR TEK
6 positive regulation of protein kinase B signaling GO:0051897 9.88 FGF2 TEK THBS1
7 positive regulation of cell migration GO:0030335 9.88 CXCL10 CXCL12 FLT1 KDR THBS1 VEGFA
8 negative regulation of endopeptidase activity GO:0010951 9.87 HRG SERPINF1 TIMP2
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.85 FLT1 KDR TEK
10 platelet degranulation GO:0002576 9.85 HRG PECAM1 PLG THBS1 VEGFA
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 FLT1 KDR TEK
12 negative regulation of angiogenesis GO:0016525 9.83 CXCL10 HRG SERPINF1 TEK THBS1
13 positive regulation of MAP kinase activity GO:0043406 9.82 FGF2 FLT1 VEGFA
14 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.81 FLT1 KDR VEGFA
15 positive regulation of endothelial cell migration GO:0010595 9.81 KDR TEK THBS1 VEGFA
16 positive regulation of blood vessel endothelial cell migration GO:0043536 9.8 FGF2 KDR THBS1 VEGFA
17 peptidyl-tyrosine phosphorylation GO:0018108 9.79 FLT1 KDR TEK
18 negative regulation of blood vessel endothelial cell migration GO:0043537 9.78 FGF2 HRG THBS1
19 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.77 FGF2 KDR VEGFA
20 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.76 FLT1 KDR VEGFA
21 positive regulation of MAPK cascade GO:0043410 9.75 FLT1 KDR TIMP2
22 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.74 FGF2 FLT1 TEK
23 sprouting angiogenesis GO:0002040 9.73 TEK THBS1 VEGFA
24 negative regulation of endothelial cell migration GO:0010596 9.72 SERPINF1 SLIT2 THBS1
25 positive regulation of sprouting angiogenesis GO:1903672 9.71 FGF2 VEGFA
26 branching morphogenesis of an epithelial tube GO:0048754 9.71 SLIT2 VEGFA
27 vascular endothelial growth factor signaling pathway GO:0038084 9.71 FLT1 KDR VEGFA
28 fibrinolysis GO:0042730 9.7 HRG PLG
29 negative regulation of fibrinolysis GO:0051918 9.7 HRG PLG THBS1
30 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.69 FLT1 VEGFA
31 positive regulation of monocyte chemotaxis GO:0090026 9.69 CXCL10 CXCL12
32 embryonic morphogenesis GO:0048598 9.68 FGF2 FLT1
33 positive regulation of T cell migration GO:2000406 9.68 CXCL10 CXCL12
34 induction of positive chemotaxis GO:0050930 9.68 CXCL12 VEGFA
35 positive regulation of phospholipase C activity GO:0010863 9.68 FGF2 FLT1
36 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
37 positive regulation of focal adhesion assembly GO:0051894 9.67 HRG KDR TEK VEGFA
38 positive regulation of axon extension involved in axon guidance GO:0048842 9.65 CXCL12 VEGFA
39 positive regulation of endothelial cell proliferation GO:0001938 9.65 CXCL12 FGF2 KDR TEK VEGFA
40 negative regulation of lamellipodium assembly GO:0010593 9.63 HRG SLIT2
41 chemotaxis GO:0006935 9.63 CXCL10 CXCL12 FGF2 FLT1 HRG SLIT2
42 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.62 KDR VEGFA
43 cell migration involved in sprouting angiogenesis GO:0002042 9.62 FGF2 KDR SLIT2 VEGFA
44 negative regulation of endothelial cell chemotaxis GO:2001027 9.6 HRG THBS1
45 positive regulation of angiogenesis GO:0045766 9.43 FGF2 FLT1 KDR TEK THBS1 VEGFA
46 angiogenesis GO:0001525 9.17 FGF2 FLT1 HRG KDR PECAM1 TEK
47 multicellular organism development GO:0007275 10.14 FGF2 FLT1 KDR SERPINF1 SLIT2 VEGFA
48 cell differentiation GO:0030154 10.04 FGF2 FLT1 KDR SLIT2 VEGFA
49 positive regulation of cell proliferation GO:0008284 10.02 CXCL10 CXCL12 FGF2 FLT1 KDR THBS1
50 regulation of signaling receptor activity GO:0010469 10 CXCL10 CXCL12 FGF2 VEGFA

Molecular functions related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.78 CXCL10 CXCL12 HRG PLG
2 cytokine activity GO:0005125 9.71 CXCL10 CXCL12 FGF2 VEGFA
3 growth factor activity GO:0008083 9.67 CXCL12 FGF2 VEGFA
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.54 FLT1 KDR TEK
5 fibronectin binding GO:0001968 9.51 THBS1 VEGFA
6 growth factor binding GO:0019838 9.5 FLT1 KDR TEK
7 proteoglycan binding GO:0043394 9.46 SLIT2 THBS1
8 vascular endothelial growth factor-activated receptor activity GO:0005021 9.43 FLT1 KDR
9 protein tyrosine kinase activity GO:0004713 9.43 FLT1 KDR TEK
10 integrin binding GO:0005178 9.35 CXCL12 FGF2 KDR THBS1 TIMP2
11 heparin binding GO:0008201 9.1 CXCL10 FGF2 HRG SLIT2 THBS1 VEGFA
12 protein binding GO:0005515 10 CXCL10 CXCL12 FGF2 FLT1 HRG KDR

Sources for Corneal Neovascularization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
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45 MeSH
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47 MGI
50 NCI
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55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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