MCID: CRN027
MIFTS: 47

Corneal Neovascularization

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Corneal Neovascularization

MalaCards integrated aliases for Corneal Neovascularization:

Name: Corneal Neovascularization 12 54 44 15 17 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11382
ICD9CM 34 370.6
MeSH 44 D016510
SNOMED-CT 67 19161004
ICD10 32 H16.4
UMLS 70 C0085109

Summaries for Corneal Neovascularization

MalaCards based summary : Corneal Neovascularization is related to keratitis, hereditary and corneal disease. An important gene associated with Corneal Neovascularization is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Bevacizumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and skin, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into... more...

Related Diseases for Corneal Neovascularization

Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 31.0 VEGFA IL1B FLT1 FGF2 CRYAA
2 corneal disease 30.8 VEGFA IL1B FGF2 CRYAA
3 diabetic macular edema 30.2 VEGFA TEK SERPINF1 FGF2
4 hemangioma 30.0 VEGFA TEK KDR FLT1 FGF2
5 eye disease 30.0 VEGFA SERPINF1 KDR IL1B FLT1 FGF2
6 uveitis 29.8 SERPINF1 IL1B CXCL10 CRYAA
7 macular retinal edema 29.7 VEGFA SERPINF1 KDR IL1B FLT1 CXCL12
8 neovascular glaucoma 29.7 VEGFA PLG KDR FLT1 FGF2 CRYAA
9 myopia 29.7 VEGFA TIMP2 SERPINF1 FGF2 CRYAA
10 vitreoretinopathy, neovascular inflammatory 29.6 VEGFA TIMP2 THBS1 FGF2 CRYAA
11 kuhnt-junius degeneration 29.6 VEGFA TEK SERPINF1 PLG KDR FLT1
12 macular degeneration, age-related, 1 29.5 VEGFA THBS1 TEK SERPINF1 PLG KDR
13 retinal vascular disease 29.2 VEGFA TEK SERPINF1 PLG KDR IL1B
14 microvascular complications of diabetes 5 29.2 VEGFA THBS1 TEK SERPINF1 PLG KDR
15 warburg-cinotti syndrome 11.2
16 yemenite deaf-blind hypopigmentation syndrome 10.5
17 septate uterus 10.4 KDR FLT1
18 familial glomangioma 10.4 TEK FGF2
19 keratopathy 10.4
20 microcystic meningioma 10.4 VEGFA FLT1
21 angiokeratoma of mibelli 10.4 KDR FLT1
22 malignant ciliary body melanoma 10.4 KDR FLT1
23 rubeosis iridis 10.4 VEGFA PLG
24 radiation proctitis 10.4 VEGFA KDR FGF2
25 proctitis 10.4 VEGFA KDR FGF2
26 corneal edema 10.4
27 epithelioid hemangioendothelioma 10.4 VEGFA KDR FLT1
28 primary cutaneous b-cell lymphoma 10.4 VEGFA KDR FLT1
29 ulcer of lower limbs 10.3 VEGFA IL1B FGF2
30 lung non-squamous non-small cell carcinoma 10.3 VEGFA KDR FLT1
31 acroosteolysis 10.3 VEGFA DDR2
32 eales disease 10.3 VEGFA SERPINF1 IL1B
33 glomeruloid hemangioma 10.3 VEGFA IL1B FLT1
34 limbal stem cell deficiency 10.3
35 decubitus ulcer 10.3 VEGFA IL1B FGF2
36 hepatic veno-occlusive disease 10.3 VEGFA PLG FGF2
37 hantavirus pulmonary syndrome 10.3 VEGFA ROBO4 KDR
38 poems syndrome 10.3 VEGFA IL1B FGF2
39 background diabetic retinopathy 10.3 VEGFA KDR IL1B
40 ischemic bone disease 10.3 VEGFA IL1B FGF2
41 vein disease 10.3 VEGFA PLG KDR
42 drug-induced lupus erythematosus 10.3 VEGFA KDR IL1B
43 cardiovascular organ benign neoplasm 10.3 VEGFA KDR FGF2
44 cancer-associated retinopathy 10.3 VEGFA FLT1
45 lymphangioma 10.3 VEGFA SERPINF1 KDR
46 hypertensive encephalopathy 10.3 VEGFA FLT1
47 bursitis 10.3 KDR IL1B CXCL12
48 chorioamnionitis 10.3 VEGFA IL1B FLT1
49 herpes simplex 10.3
50 ectopic pregnancy 10.3 VEGFA IL1B FLT1

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to Corneal Neovascularization

Symptoms & Phenotypes for Corneal Neovascularization

MGI Mouse Phenotypes related to Corneal Neovascularization:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 CXCL10 CXCL12 DDR2 FGF2 FLT1 IL1B
2 homeostasis/metabolism MP:0005376 10.2 CCR3 CXCL10 DDR2 FGF2 FLT1 IL1B
3 cellular MP:0005384 10.18 CCR3 CXCL10 CXCL12 DDR2 FGF2 FLT1
4 hematopoietic system MP:0005397 10.18 CCR3 CXCL10 CXCL12 FGF2 FLT1 IL1B
5 integument MP:0010771 9.91 DDR2 IL1B KDR PLG ROBO4 SLIT2
6 nervous system MP:0003631 9.83 CXCL10 CXCL12 DDR2 FGF2 FLT1 IL1B
7 muscle MP:0005369 9.81 CXCL12 DDR2 FGF2 FLT1 KDR ROBO4
8 vision/eye MP:0005391 9.32 DDR2 FGF2 FLT1 KDR PLG SERPINF1

Drugs & Therapeutics for Corneal Neovascularization

Drugs for Corneal Neovascularization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Immunoglobulins Phase 4
3 Antibodies Phase 4
4 Pharmaceutical Solutions Phase 4
5 Antibodies, Monoclonal Phase 4
6 Anesthetics Phase 4
7 Antineoplastic Agents, Immunological Phase 4
8 Angiogenesis Inhibitors Phase 4
9
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
11
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 83-88-5 493570
12 Triamcinolone diacetate Phase 2, Phase 3
13 Triamcinolone hexacetonide Phase 2, Phase 3
14 triamcinolone acetonide Phase 2, Phase 3
15 Ophthalmic Solutions Phase 2, Phase 3
16 Photosensitizing Agents Phase 2, Phase 3
17 Dermatologic Agents Phase 2, Phase 3
18 Micronutrients Phase 2, Phase 3
19 Trace Elements Phase 2, Phase 3
20 Vitamin B9 Phase 2, Phase 3
21 Nutrients Phase 2, Phase 3
22 Vitamin B Complex Phase 2, Phase 3
23 Folate Phase 2, Phase 3
24 Vitamins Phase 2, Phase 3
25 Vitamin B2 Phase 2, Phase 3
26 Mitogens Phase 2
27 Endothelial Growth Factors Phase 2
28 Gastrointestinal Agents Phase 1, Phase 2
29 Cathartics Phase 1, Phase 2
30 Carboxymethylcellulose Sodium Phase 1, Phase 2
31 Laxatives Phase 1, Phase 2
32 Antirheumatic Agents Phase 1, Phase 2
33 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
34
Ranibizumab Approved Phase 1 347396-82-1 459903
35
Methylprednisolone hemisuccinate Approved 2921-57-5
36
Methylprednisolone Approved, Vet_approved 83-43-2 6741
37
Prednisolone Approved, Vet_approved 50-24-8 5755
38
Prednisolone acetate Approved, Vet_approved 52-21-1
39
Prednisolone phosphate Approved, Vet_approved 302-25-0
40
Verteporfin Approved, Investigational 129497-78-5
41
Prednisolone hemisuccinate Experimental 2920-86-7
42 Methylprednisolone Acetate
43 Hormones
44 glucocorticoids
45 Hormone Antagonists
46 Antineoplastic Agents, Hormonal
47 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Management of Active and Established Corneal Neovascularisation to Prevent Visual Impairment Unknown status NCT02594423 Phase 4 Bevacizumab
2 The Effect of Bevacizumab on Corneal Neovascularization Completed NCT00797303 Phase 4 Bevacizumab
3 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3 Bevacizumab (Avastin)
4 Randomized Comparison of Standard vs. Accelerated Corneal Crosslinking for Treatment of Corneal Neovascularization With or Without Concomitant Inflammation and/or Infection Not yet recruiting NCT04787471 Phase 2, Phase 3
5 Topical/Subconjunctival Injection of Bevacizumab(Avastin) for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
6 Safety and Efficacy of Topical Pazopanib in Treatment of Corneal Neovascularization Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
7 Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01072357 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
8 A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01996826 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
9 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
10 The Effect of Subconjunctival Aflibercept on Regression of Corneal Neovascularization Terminated NCT02797704 Phase 1, Phase 2 Aflibercept
11 Topical IL-1-Ra for Treatment of Corneal Neovascularization Terminated NCT00915590 Phase 1, Phase 2 Placebo;IL-1Ra
12 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00559936 Phase 1 Topical Avastin 1%
13 Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery Completed NCT00769145 Phase 1 Ranibizumab
14 Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV) Completed NCT00681889 Phase 1 Ranibizumab
15 A Phase 1 Randomized, Double Blinded, Placebo-Controlled Single Dose and Repeat Dose Escalation Study to Evaluate Safety and Tolerability and Pharmacokinetic Characteristics of KDR2-2 in Adult Healthy Male and Female Volunteers Recruiting NCT04620109 Phase 1 KDR2-2;Placebo
16 An Exploratory Clinical Trial Evaluating the Tolerability and Efficacy of Conbercept Eye Drops in Patients With Corneal Neovascularization Recruiting NCT04215393 Phase 1 Conbercept eye drop;Placebo
17 Subconjunctival Aflibercept Injection for Corneal Neovascularization Terminated NCT01868360 Phase 1 Subconjunctival aflibercept
18 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
19 The Application of Subconjunctival Injection of Bevacizumab (Avastin) in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
20 Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization Completed NCT00004430 Dihematoporphyrin derivative;prednisolone
21 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00512876 Bevacizumab (Avastin)
22 Photodynamic Therapy With Verteporfin for Corneal Neovascularization Completed NCT00471406
23 Corneal Thinning During Topical Bevacizumab Therapy Withdrawn NCT00515684 bevacizumab (Avastin)

Search NIH Clinical Center for Corneal Neovascularization

Cochrane evidence based reviews: corneal neovascularization

Genetic Tests for Corneal Neovascularization

Anatomical Context for Corneal Neovascularization

MalaCards organs/tissues related to Corneal Neovascularization:

40
Eye, Endothelial, Skin, Bone, Bone Marrow, Placenta, Lung

Publications for Corneal Neovascularization

Articles related to Corneal Neovascularization:

(show top 50) (show all 1443)
# Title Authors PMID Year
1
A siRNA targeting vascular endothelial growth factor-A inhibiting experimental corneal neovascularization. 61 54
20450250 2010
2
VEGF Trap(R1R2) suppresses experimental corneal angiogenesis. 61 54
19882518 2010
3
Pterygia: pathogenesis and the role of subconjunctival bevacizumab in treatment. 61 54
19437347 2009
4
Evaluation of cytotoxic effects of bevacizumab on human corneal cells. 54 61
19387236 2009
5
Analysis of angiogenesis induced by cultured corneal and oral mucosal epithelial cell sheets in vitro. 54 61
17904552 2007
6
Inhibition of corneal neovascularization with a nutrient mixture containing lysine, proline, ascorbic acid, and green tea extract. 61 54
17845900 2007
7
Inhibition of corneal neovascularization by recombinant adenovirus-mediated sFlk-1 expression. 54 61
17692288 2007
8
[A synthetic peptide selected by bioinformatics inhibits mouse corneal neovascularization]. 61 54
17459247 2007
9
A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents. 54 61
17107753 2007
10
Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization. 54 61
17198016 2007
11
Inhibition of corneal neovascularization by rapamycin. 54 61
16672771 2006
12
Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders. 61 54
16195702 2006
13
Proteomic identification of activin receptor-like kinase-1 as a differentially expressed protein during hyaloid vascular system regression. 54 61
16223497 2005
14
Differential conversion of plasminogen to angiostatin by human corneal cell populations. 61 54
16270025 2005
15
Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo. 61 54
15851564 2005
16
Corneal neovascularization suppressed by TIMP2 released from human amniotic membranes. 61 54
17162918 2005
17
Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. 61 54
15326102 2004
18
Suppression of corneal neovascularization by PEDF release from human amniotic membranes. 54 61
15161837 2004
19
Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. 61 54
15126605 2004
20
[Suppression of corneal neovascularization by conditioned culture medium of human amniotic membrane]. 61 54
14769230 2003
21
Thrombospondins 1 and 2 function as inhibitors of angiogenesis. 54 61
12714043 2003
22
VEGF-dependent conjunctivalization of the corneal surface. 61 54
12506063 2003
23
Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA. 54 61
12470964 2002
24
[Expression of vascular endothelial growth factor and its receptors (flt-1) in morbid human corneas and investigation of its clinic importance]. 54 61
15515760 2002
25
Inhibition of prostate tumor angiogenesis by the tumor suppressor CEACAM1. 61 54
12122002 2002
26
Suppression of corneal neovascularization by culture supernatant of human amniotic cells. 61 54
11805510 2002
27
HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. 61 54
11118060 2000
28
Towards a closed eye model of the pre-ocular tear layer. 61 54
11029550 2000
29
Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas. 61 54
10937562 2000
30
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. 54 61
10202935 1999
31
Diurnal variations in angiostatin in human tear fluid: a possible role in prevention of corneal neovascularization. 54 61
10342373 1999
32
Inhibition of angiogenesis by interleukin 4. 54 61
9743522 1998
33
The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization. 61 54
9733580 1998
34
The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. 61 54
9233641 1997
35
[Inhibition of neovascularization of the eye by dietary factors exemplified by isoflavonoids]. 61 54
9156641 1997
36
Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. 54 61
8988045 1997
37
The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. 54 61
7592998 1995
38
The role of CXC chemokines as regulators of angiogenesis. 61 54
8574748 1995
39
Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor. 61 54
8927305 1995
40
Recombinant human epidermal growth factor and corneal neovascularization. 61 54
1289616 1992
41
[Pathophysiology of intraocular neovascularization]. 61 54
1707214 1990
42
Ocular lamellar crystalline gels for sustained release and enhanced permeation of resveratrol against corneal neovascularization. 61
33472443 2021
43
Ocular toxicity of mustard gas: A concise review. 61
33600921 2021
44
Subconjunctival Aflibercept for the Treatment of Formed Corneal Neovascularization. 61
32443011 2021
45
Inhibition of PDGF-BB reduces alkali-induced corneal neovascularization in mice. 61
33537811 2021
46
Comparative Study on the Efficacy of Frozen Amniotic Membrane Transplantation and Lamellar Keratoplasty in the Treatment of Mooren Ulcer. 61
33704999 2021
47
The Role of Inflammatory Cytokines in Neovascularization of Chemical Ocular Injury. 61
33734925 2021
48
Spatial distribution of mast cells regulates asymmetrical angiogenesis at the ocular surface. 61
33705754 2021
49
Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea. 61
33199821 2021
50
Novel Parameters to Assess the Severity of Corneal Neovascularization Using Anterior Segment Optical Coherence Tomography Angiography. 61
32822670 2021

Variations for Corneal Neovascularization

Expression for Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for Corneal Neovascularization

Pathways related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 TIMP4 TIMP2 SERPINF1 PLG KDR IL1B
2
Show member pathways
13.76 VEGFA TIMP4 TIMP2 TEK KDR IL1B
3
Show member pathways
13.66 VEGFA TIMP4 TIMP2 TEK KDR FLT1
4
Show member pathways
13.64 TEK SERPINF1 KDR IL1B FLT1 DDR2
5
Show member pathways
13.52 TIMP4 TIMP2 TEK KDR FLT1 FGF2
6
Show member pathways
13.5 VEGFA TIMP4 TIMP2 TEK KDR IL1B
7
Show member pathways
13.37 VEGFA THBS1 PLG KDR CXCL12 CXCL10
8
Show member pathways
13.3 TIMP4 TIMP2 TEK KDR FLT1 FGF2
9
Show member pathways
13.24 VEGFA TIMP4 TIMP2 TEK KDR FLT1
10
Show member pathways
13.14 TIMP4 TIMP2 TEK KDR IL1B FLT1
11
Show member pathways
13.13 TIMP4 TIMP2 TEK KDR IL1B FLT1
12
Show member pathways
13.03 TIMP4 TIMP2 KDR FLT1 FGF2 CXCL12
13
Show member pathways
13.03 TIMP4 TIMP2 KDR FLT1 FGF2 DDR2
14
Show member pathways
12.95 VEGFA THBS1 TEK KDR FLT1 FGF2
15 12.74 VEGFA TEK KDR IL1B FLT1 FGF2
16
Show member pathways
12.72 TIMP2 THBS1 PLG KDR FGF2 DDR2
17
Show member pathways
12.71 VEGFA THBS1 TEK KDR FLT1 FGF2
18
Show member pathways
12.66 TIMP4 TIMP2 KDR IL1B FLT1 FGF2
19
Show member pathways
12.35 VEGFA KDR FLT1 FGF2
20 12.35 VEGFA KDR FLT1 FGF2
21
Show member pathways
12.31 VEGFA KDR FLT1 FGF2
22 12.26 VEGFA THBS1 KDR FGF2
23
Show member pathways
12.22 TIMP4 TIMP2 TEK KDR FLT1 FGF2
24
Show member pathways
12.16 TIMP4 TIMP2 KDR IL1B FLT1 FGF2
25 12.13 TEK KDR FLT1 FGF2 DDR2
26
Show member pathways
11.86 TIMP4 TIMP2 PLG
27
Show member pathways
11.82 VEGFA KDR FLT1
28 11.82 VEGFA TEK IL1B FLT1 CXCL12
29 11.64 VEGFA FGF2 DDR2
30 11.62 IL1B FGF2 CCR3
31 11.58 TIMP2 THBS1 TEK KDR FLT1 FGF2
32 11.54 VEGFA PLG KDR FGF2
33 11.47 VEGFA KDR FGF2
34 11.46 VEGFA KDR FLT1 FGF2
35 11.33 VEGFA KDR FLT1
36 11.27 THBS1 PLG FGF2 CXCL12
37 11.19 TIMP2 IL1B CCR3
38 11.15 VEGFA SLIT2 FLT1 FGF2
39
Show member pathways
10.96 VEGFA KDR FLT1
40 10.79 PLG HRG
41 10.56 TIMP4 TIMP2 TEK KDR IL1B FLT1
42 10.48 VEGFA TIMP2 TEK KDR FLT1 FGF2

GO Terms for Corneal Neovascularization

Cellular components related to Corneal Neovascularization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 VEGFA TIMP2 THBS1 TEK PLG HRG
2 collagen-containing extracellular matrix GO:0062023 9.73 TIMP2 THBS1 SERPINF1 PLG HRG CXCL12
3 extracellular space GO:0005615 9.73 VEGFA TIMP4 TIMP2 THBS1 SLIT2 SERPINF1
4 extracellular matrix GO:0031012 9.71 VEGFA TIMP4 TIMP2 THBS1
5 receptor complex GO:0043235 9.67 TEK KDR FLT1 DDR2
6 extracellular region GO:0005576 9.5 VEGFA TIMP4 TIMP2 THBS1 TEK SLIT2
7 platelet alpha granule lumen GO:0031093 9.46 VEGFA THBS1 PLG HRG

Biological processes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.19 VEGFA TEK SLIT2 ROBO4 KDR FLT1
2 negative regulation of apoptotic process GO:0043066 10.11 VEGFA THBS1 TEK KDR CRYAA
3 immune response GO:0006955 10.1 THBS1 IL1B CXCL12 CXCL10 CCR3
4 extracellular matrix organization GO:0030198 10.01 THBS1 KDR FGF2 DDR2
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10 VEGFA TEK KDR FGF2
6 positive regulation of protein kinase B signaling GO:0051897 9.98 VEGFA THBS1 TEK FGF2
7 response to hypoxia GO:0001666 9.97 VEGFA THBS1 TEK CXCL12
8 protein autophosphorylation GO:0046777 9.97 TEK KDR FLT1 DDR2
9 positive regulation of protein phosphorylation GO:0001934 9.97 VEGFA TEK KDR IL1B FGF2
10 positive regulation of cell migration GO:0030335 9.95 VEGFA THBS1 KDR IL1B FLT1 CXCL12
11 negative regulation of endopeptidase activity GO:0010951 9.94 TIMP4 TIMP2 SERPINF1 HRG
12 peptidyl-tyrosine phosphorylation GO:0018108 9.93 TEK KDR FLT1 DDR2
13 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.92 TEK KDR FLT1 DDR2
14 negative regulation of angiogenesis GO:0016525 9.91 THBS1 TEK SERPINF1 HRG CXCL10
15 angiogenesis GO:0001525 9.91 VEGFA TEK ROBO4 KDR HRG FLT1
16 positive regulation of cell proliferation GO:0008284 9.91 VEGFA THBS1 KDR IL1B FLT1 FGF2
17 platelet degranulation GO:0002576 9.9 VEGFA THBS1 PLG HRG
18 response to organic substance GO:0010033 9.89 TIMP4 TIMP2 TEK
19 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.89 VEGFA TEK KDR FLT1 FGF2
20 chemokine-mediated signaling pathway GO:0070098 9.88 CXCL12 CXCL10 CCR3
21 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.86 VEGFA KDR FLT1
22 response to peptide hormone GO:0043434 9.86 TIMP4 TEK CXCL12
23 positive regulation of kinase activity GO:0033674 9.86 TEK KDR FLT1 DDR2
24 positive regulation of MAP kinase activity GO:0043406 9.85 VEGFA FLT1 FGF2
25 positive regulation of endothelial cell migration GO:0010595 9.85 VEGFA THBS1 TEK KDR FGF2
26 positive regulation of cell division GO:0051781 9.83 VEGFA IL1B FGF2
27 positive chemotaxis GO:0050918 9.83 VEGFA FGF2 CXCL10
28 positive regulation of blood vessel endothelial cell migration GO:0043536 9.83 VEGFA THBS1 KDR FGF2
29 negative regulation of blood vessel endothelial cell migration GO:0043537 9.82 THBS1 HRG FGF2
30 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.8 VEGFA KDR FGF2
31 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.8 VEGFA KDR FLT1
32 positive regulation of MAPK cascade GO:0043410 9.8 VEGFA TIMP2 TEK KDR FLT1 FGF2
33 sprouting angiogenesis GO:0002040 9.78 VEGFA THBS1 TEK
34 positive regulation of focal adhesion assembly GO:0051894 9.78 VEGFA TEK KDR HRG
35 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.77 TEK FLT1 FGF2
36 negative regulation of endothelial cell migration GO:0010596 9.75 THBS1 SLIT2 SERPINF1
37 cell migration involved in sprouting angiogenesis GO:0002042 9.73 VEGFA SLIT2 KDR FGF2
38 positive regulation of DNA biosynthetic process GO:2000573 9.72 VEGFA FGF2
39 induction of positive chemotaxis GO:0050930 9.72 VEGFA CXCL12
40 positive regulation of fibroblast migration GO:0010763 9.72 THBS1 DDR2
41 vascular endothelial growth factor signaling pathway GO:0038084 9.72 VEGFA KDR FLT1
42 positive regulation of phospholipase C activity GO:0010863 9.71 FLT1 FGF2
43 positive regulation of positive chemotaxis GO:0050927 9.71 VEGFA KDR
44 negative regulation of fibrinolysis GO:0051918 9.71 THBS1 PLG HRG
45 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.7 VEGFA PLG
46 ovulation cycle GO:0042698 9.7 TIMP4 SERPINF1
47 chemotaxis GO:0006935 9.7 SLIT2 HRG FLT1 FGF2 CXCL12 CXCL10
48 vascular wound healing GO:0061042 9.69 VEGFA KDR
49 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.69 TIMP4 TIMP2
50 positive regulation of axon extension involved in axon guidance GO:0048842 9.68 VEGFA CXCL12

Molecular functions related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.43 VEGFA TIMP4 TIMP2 THBS1 TEK SLIT2
2 cytokine activity GO:0005125 9.65 VEGFA IL1B FGF2 CXCL12 CXCL10
3 protein tyrosine kinase activity GO:0004713 9.62 TEK KDR FLT1 DDR2
4 growth factor binding GO:0019838 9.58 TEK KDR FLT1
5 chemoattractant activity GO:0042056 9.54 VEGFA FGF2 CXCL10
6 CXCR chemokine receptor binding GO:0045236 9.49 CXCL12 CXCL10
7 proteoglycan binding GO:0043394 9.48 THBS1 SLIT2
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.46 TEK KDR FLT1 DDR2
9 vascular endothelial growth factor-activated receptor activity GO:0005021 9.43 KDR FLT1
10 heparin binding GO:0008201 9.43 VEGFA THBS1 SLIT2 HRG FGF2 CXCL10
11 integrin binding GO:0005178 9.1 TIMP2 THBS1 KDR IL1B FGF2 CXCL12

Sources for Corneal Neovascularization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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