MCID: CRN027
MIFTS: 51

Corneal Neovascularization

Categories: Eye diseases

Aliases & Classifications for Corneal Neovascularization

MalaCards integrated aliases for Corneal Neovascularization:

Name: Corneal Neovascularization 12 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11382
ICD10 33 H16.4 H16.40
ICD9CM 35 370.6 370.60
MeSH 44 D016510
SNOMED-CT 68 19161004
UMLS 73 C0085109

Summaries for Corneal Neovascularization

MalaCards based summary : Corneal Neovascularization is related to retinal vascular disease and glomeruloid hemangioma. An important gene associated with Corneal Neovascularization is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Bevacizumab and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and brain, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 76 Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into... more...

Related Diseases for Corneal Neovascularization

Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 retinal vascular disease 29.6 FLT1 KDR PLG SERPINF1 VEGFA
2 glomeruloid hemangioma 10.2 FLT1 VEGFA
3 hemangioendothelioma 10.2 KDR PLG
4 vitreous detachment 10.2 PLG VEGFA
5 critical limb ischemia 10.2 TEK VEGFA
6 angiodysplasia 10.2 FGF2 VEGFA
7 macular dystrophy, dominant cystoid 10.2 SERPINF1 VEGFA
8 pyogenic granuloma 10.2 TEK VEGFA
9 diabetic cataract 10.2 SERPINF1 VEGFA
10 cancer-associated retinopathy 10.2 FLT1 VEGFA
11 blood group, globoside system 10.2 PLG VEGFA
12 radiation proctitis 10.1 FGF2 KDR VEGFA
13 angiokeratoma circumscriptum 10.1 FLT1 KDR VEGFA
14 bursitis 10.1 CXCL12 KDR
15 skin hemangioma 10.1 FLT1 KDR VEGFA
16 lymphangioma 10.1 KDR SERPINF1 VEGFA
17 angiomatous meningioma 10.1 FGF2 KDR VEGFA
18 epithelioid hemangioendothelioma 10.1 FLT1 KDR VEGFA
19 endophthalmitis 10.1 PLG VEGFA
20 vitreous disease 10.1 FGF2 PLG VEGFA
21 posterior uveal melanoma 10.1 THBS1 VEGFA
22 keratopathy 10.1
23 limbal stem cell deficiency 10.1
24 stromal keratitis 10.1
25 arteries, anomalies of 10.1 FLT1 PLG VEGFA
26 retinal vascular occlusion 10.1 PLG VEGFA
27 kaposi sarcoma 10.1 FGF2 KDR VEGFA
28 clivus chordoma 10.1 CXCL12 FGF2
29 differentiated thyroid carcinoma 10.1 CD36 FLT1 VEGFA
30 burns 10.1
31 placenta accreta 10.1 FLT1 TEK
32 diabetic macular edema 10.0 FGF2 SERPINF1 TEK VEGFA
33 arteriovenous malformations of the brain 10.0 KDR THBS1 VEGFA
34 platelet glycoprotein iv deficiency 10.0 CD36 THBS1
35 renal cell carcinoma, nonpapillary 10.0 FGF2 FLT1 KDR VEGFA
36 capillary hemangioma 10.0 FLT1 KDR TEK VEGFA
37 chronic myocardial ischemia 10.0 FGF2 PLG TEK VEGFA
38 babesiosis 10.0 CD36 THBS1
39 placental insufficiency 10.0 FLT1 KDR TEK VEGFA
40 angiosarcoma 10.0 FLT1 KDR TEK VEGFA
41 exudative vitreoretinopathy 1 10.0 FLT1 KDR TEK VEGFA
42 odontogenic myxoma 10.0 CD36 VEGFA
43 breast disease 10.0 TEK THBS1 VEGFA
44 large intestine cancer 10.0 CXCL12 FLT1 KDR VEGFA
45 drug-induced lupus erythematosus 10.0 KDR VEGFA
46 herpes simplex 10.0
47 hypoxia 10.0
48 microcystic meningioma 10.0 FLT1 TIMP2 VEGFA
49 dupuytren contracture 9.9 FGF2 TIMP2 VEGFA
50 lipodermatosclerosis 9.9 FLT1 TIMP2 VEGFA

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to Corneal Neovascularization

Symptoms & Phenotypes for Corneal Neovascularization

MGI Mouse Phenotypes related to Corneal Neovascularization:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 CD36 CXCL10 CXCL12 FGF2 FLT1 KDR
2 hematopoietic system MP:0005397 10.29 CD36 CXCL10 CXCL12 FGF2 FLT1 KDR
3 cellular MP:0005384 10.21 CD36 CXCL10 CXCL12 FGF2 FLT1 KDR
4 homeostasis/metabolism MP:0005376 10.2 CD36 CXCL10 FGF2 FLT1 KDR PLG
5 immune system MP:0005387 10.17 CD36 CXCL10 CXCL12 FLT1 KDR PLG
6 mortality/aging MP:0010768 10.11 CD36 CXCL10 CXCL12 FGF2 FLT1 KDR
7 nervous system MP:0003631 10.03 CD36 CXCL10 CXCL12 FGF2 FLT1 KDR
8 digestive/alimentary MP:0005381 9.97 CD36 PLG SERPINF1 THBS1 VEGFA XBP1
9 muscle MP:0005369 9.97 CD36 CXCL12 FGF2 FLT1 KDR TEK
10 liver/biliary system MP:0005370 9.95 CD36 CXCL12 KDR PLG THBS1 VEGFA
11 reproductive system MP:0005389 9.7 CXCL12 FGF2 FLT1 PLG SERPINF1 THBS1
12 skeleton MP:0005390 9.5 CD36 FGF2 KDR SERPINF1 THBS1 VEGFA
13 vision/eye MP:0005391 9.32 CD36 FGF2 FLT1 KDR PLG SERPINF1

Drugs & Therapeutics for Corneal Neovascularization

Drugs for Corneal Neovascularization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 216974-75-3
2 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2,Not Applicable
3 Antibodies Phase 4,Phase 2,Phase 1
4 Immunoglobulins Phase 4,Phase 2,Phase 1
5 Anesthetics Phase 4,Phase 2
6 Antibodies, Monoclonal Phase 4,Phase 2
7 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
8 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
9
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
10
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 5280972
11
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
12
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
13
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1,Not Applicable 22916-47-8 4189
14
Natamycin Approved Phase 3 7681-93-8 5281099
15 Antiparasitic Agents Phase 2, Phase 3
16 Antiprotozoal Agents Phase 2, Phase 3
17 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3,Phase 1
18 Antimalarials Phase 2, Phase 3
19 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
20 Endothelial Growth Factors Phase 2, Phase 3
21 Mitogens Phase 2, Phase 3
22 triamcinolone acetonide Phase 2, Phase 3
23 Triamcinolone diacetate Phase 2, Phase 3
24 Triamcinolone hexacetonide Phase 2, Phase 3
25 Cytochrome P-450 CYP3A Inhibitors Phase 3
26 Hormones Phase 3,Not Applicable
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Steroid Synthesis Inhibitors Phase 3
29 Antifungal Agents Phase 3,Phase 1,Not Applicable
30 Hormone Antagonists Phase 3,Not Applicable
31 Anti-Infective Agents, Local Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
33 Laxatives Phase 1, Phase 2,Phase 2
34 Carboxymethylcellulose Sodium Phase 1, Phase 2,Phase 2
35 Cathartics Phase 1, Phase 2,Phase 2
36 Gastrointestinal Agents Phase 1, Phase 2,Phase 2
37 Antirheumatic Agents Phase 1, Phase 2,Not Applicable
38 Ophthalmic Solutions Phase 1, Phase 2,Not Applicable
39 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
40
Ranibizumab Approved Phase 1 347396-82-1 459903
41
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
42
Tropicamide Approved, Investigational Phase 1 1508-75-4 5593
43
Zinc Approved, Investigational Phase 1 7440-66-6
44 Immunologic Factors Phase 1,Not Applicable
45 Gentamicins Phase 1
46 Betamethasone sodium phosphate Phase 1
47 Betamethasone Valerate Phase 1 2152-44-5
48 Betamethasone benzoate Phase 1
49 Lubricant Eye Drops Phase 1
50 Betamethasone-17,21-dipropionate Phase 1

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Strategies for Management of Corneal Neovascularisation Unknown status NCT02594423 Phase 4 Bevacizumab
2 The Effect of Bevacizumab on Corneal Neovascularization Completed NCT00797303 Phase 4 Bevacizumab
3 Comparative Performance of PureVision, Acuvue Oasys and O2Optix Completed NCT00640341 Phase 4
4 Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism Completed NCT01965288 Phase 4
5 Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency Recruiting NCT02577861 Phase 4
6 The Role of Amniotic Membrane Transplantation in Ocular Chemical Burns Unknown status NCT00370812 Phase 2, Phase 3
7 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3 Doxycycline;Placebo
8 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3 Bevacizumab (Avastin)
9 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Completed NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
10 Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency Withdrawn NCT01489501 Phase 3
11 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
12 Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization Unknown status NCT02797704 Phase 1, Phase 2 Aflibercept
13 Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose Unknown status NCT02157987 Phase 1, Phase 2 bevacuzimab spray
14 Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease Unknown status NCT03015779 Phase 1, Phase 2
15 Cell Therapy in Failure Syndromes in Limbal Stem Cells Unknown status NCT01619189 Phase 2
16 the Treatment of Human Bone Marrow Mesenchymal Stem Cells in Ocular Corneal Burn Unknown status NCT02325843 Phase 2
17 Treatment of Corneal Neovascularization With Topical Pazopanib Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
18 Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01072357 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
19 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
20 Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo Completed NCT01470573 Phase 2
21 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
22 Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment Recruiting NCT01765244 Phase 1, Phase 2 Anterior lamellar nanostructured artificial human cornea.
23 Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Recruiting NCT02318485 Phase 2
24 A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Active, not recruiting NCT01996826 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
25 Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases Active, not recruiting NCT02739113 Phase 1, Phase 2
26 Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD Not yet recruiting NCT03549299 Phase 1, Phase 2
27 Topical IL-1-Ra for Treatment of Corneal Neovascularization Terminated NCT00915590 Phase 1, Phase 2 Placebo;IL-1Ra
28 Topical Avastin for Treatment of Corneal Neovascularization Completed NCT00559936 Phase 1 Topical Avastin 1%
29 Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV) Completed NCT00681889 Phase 1 Ranibizumab
30 Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery Completed NCT00769145 Phase 1 Ranibizumab
31 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
32 Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
33 The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED) Completed NCT02649621 Phase 1
34 Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea Terminated NCT01868360 Phase 1 Subconjunctival aflibercept
35 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
36 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
37 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00512876 Not Applicable Bevacizumab (Avastin)
38 Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization Completed NCT00004430 Not Applicable Dihematoporphyrin derivative;prednisolone
39 Photodynamic Therapy With Verteporfin for Corneal Neovascularization Completed NCT00471406 Not Applicable
40 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 Not Applicable subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
41 Neovascularization Patterns in Corneal Graft Rejection Completed NCT01695655
42 Comparison of Subconjuctival Versus Topical Bevacizumab as Adjunct Therapy to Trabeculectomy Completed NCT01425112 Not Applicable
43 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Not Applicable Cyclosporin 0.05% ophthalmic
44 Product Performance of a Toric Contact Lens Completed NCT00658996 Not Applicable
45 A Study to Evaluate the Clinical Performance of a Novel Multipurpose Solution Completed NCT01024751 Not Applicable
46 A Study to Evaluate the Product Performance of a Daily Disposable Contact Lens Completed NCT01192126 Not Applicable
47 Vistakon Investigational Multi-purpose Contact Lens Care Solution. Completed NCT01055457 Not Applicable
48 Evaluation of a New Silicone Hydrogel Contact Lens Completed NCT01309880 Not Applicable
49 Vistakon Investigational Lens Worn as a Single Use Daily Wear Completed NCT01031004 Not Applicable
50 The Clinical and Subjective Performance of Three Different MPDS With Silicon Hydrogel Lenses Completed NCT01665612 Not Applicable

Search NIH Clinical Center for Corneal Neovascularization

Cochrane evidence based reviews: corneal neovascularization

Genetic Tests for Corneal Neovascularization

Genetic tests related to Corneal Neovascularization:

# Genetic test Affiliating Genes
1 Corneal Neovascularization 29

Anatomical Context for Corneal Neovascularization

MalaCards organs/tissues related to Corneal Neovascularization:

41
Eye, Endothelial, Brain, B Cells, Skin, Breast, Placenta

Publications for Corneal Neovascularization

Articles related to Corneal Neovascularization:

(show top 50) (show all 494)
# Title Authors Year
1
Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn. ( 30551354 )
2019
2
Epigallocatechin gallate inhibits corneal neovascularization in ratalkaline burn model. ( 29731448 )
2018
3
A Case of Corneal Neovascularization Misdiagnosed as Total Limbal Stem Cell Deficiency. ( 29781927 )
2018
4
Substance P Modulation of Human and Murine Corneal Neovascularization. ( 29625453 )
2018
5
Effect of metronidazole ophthalmic solution on corneal neovascularization in a rat model. ( 29700650 )
2018
6
Is Sesamol Effective in Corneal Neovascularization? ( 29944496 )
2018
7
Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFI_B/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization. ( 29801148 )
2018
8
Ginsenoside Rh2 inhibits vascular endothelial growth factor-induced corneal neovascularization. ( 29465315 )
2018
9
Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography. ( 29625447 )
2018
10
MicroRNA-296 mediated corneal neovascularization in an animal model of corneal burns after alkali exposures. ( 29399058 )
2018
11
Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2a89mediated STAT3/PI3K/Akt signaling pathway. ( 29717775 )
2018
12
Inhibitory Effects of <i>Glycyrrhiza glabra</i> and Its Major Constituent Glycyrrhizin on Inflammation-Associated Corneal Neovascularization. ( 29849730 )
2018
13
Current and upcoming therapies for corneal neovascularization. ( 29908870 )
2018
14
Successful single treatment with ziv-aflibercept for existing corneal neovascularization following ocular chemical insult in the rabbit model. ( 29548928 )
2018
15
Epithelium-derived miR-204 inhibits corneal neovascularization. ( 29246498 )
2018
16
Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Corneal Neovascularization in Rabbits. ( 29533953 )
2018
17
In Vivo Confocal Microscopic Study of Hard Contact Lens-Induced Lipid Keratopathy Secondary to Corneal Neovascularization in a Rabbit Hypercholesterolemic Model. ( 29489496 )
2018
18
B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model. ( 29515217 )
2018
19
Gene-based antiangiogenic applications for corneal neovascularization. ( 29080632 )
2018
20
Topical axitinib is a potent inhibitor of corneal neovascularization. ( 29888852 )
2018
21
Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization. ( 29445990 )
2018
22
The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor. ( 30254425 )
2018
23
Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography. ( 30280000 )
2018
24
Activation of Toll-like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF-1-mediated endothelial progenitor cell recruitment. ( 30321512 )
2018
25
LncRNA NEAT1 promotes inflammatory response and induces corneal neovascularization ( 30328354 )
2018
26
Inhibited Corneal Neovascularization in Rabbits following Corneal Alkali Burn by Double-Target Interference for VEGF and HIF-1α. ( 30355648 )
2018
27
Effect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in Rabbits. ( 30402279 )
2018
28
Propranolol eye drops in patients with corneal neovascularization. ( 30407290 )
2018
29
Long-term outcome of using Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) as a drug delivery system for bevacizumab in the treatment of corneal neovascularization. ( 30468876 )
2018
30
Antiangiogenic effects of catalpol on rat corneal neovascularization. ( 29207076 )
2018
31
Efficacy of fumagillin bicyclohexylamine on experimental corneal neovascularization in rat model. ( 30006905 )
2018
32
Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage. ( 30029250 )
2018
33
Comparison of the inhibitory effect of different doses of subconjunctival bevacizumab application in an experimental model of corneal neovascularization. ( 30046522 )
2018
34
Autocrine IL-1β Mediates the Promotion of Senescent Fibroblasts on Corneal Neovascularization. ( 30156862 )
2018
35
Prevention of corneal neovascularization by subconjunctival injection of avastin® loaded thermosensitive hydrogels in rabbit model. ( 30217769 )
2018
36
Streptozotocin‑induced diabetic mice exhibit reduced experimental choroidal neovascularization but not corneal neovascularization. ( 30221697 )
2018
37
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. ( 28924439 )
2017
38
Topical versus subconjunctival anti-vascular endothelial growth factor therapy (Bevacizumab, Ranibizumab and Aflibercept) for treatment of corneal neovascularization. ( 28559722 )
2017
39
Inhibitory effects of S100A4 gene silencing on alkali burn-induced corneal neovascularization: an in vivo study. ( 28479848 )
2017
40
Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization. ( 28393322 )
2017
41
Critical Contact Lens Oxygen Transmissibility and Tear Lens Oxygen Tension to Preclude Corneal Neovascularization. ( 28799960 )
2017
42
Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis. ( 28055102 )
2017
43
Immunophysical analysis of corneal neovascularization: mechanistic insights and implications for pharmacotherapy. ( 28939878 )
2017
44
Therapeutic Potential of Ranibizumab in Corneal Neovascularization. ( 28606479 )
2017
45
Topical Timolol Inhibits Corneal Neovascularization in Rabbits. ( 29367933 )
2017
46
Effectiveness of photodynamic therapy with verteporfin combined with intrastromal bevacizumab for corneal neovascularization in Stevens-Johnson syndrome. ( 29256167 )
2017
47
Evaluation of Corneal Neovascularization Using Optical Coherence Tomography Angiography in Patients With Limbal Stem Cell Deficiency. ( 28922332 )
2017
48
Recent drug therapies for corneal neovascularization. ( 28489275 )
2017
49
Suppression of corneal neovascularization by curcumin<i>via</i>inhibition of Wnt/I^-catenin pathway activation. ( 29259894 )
2017
50
Effect of Histone Deacetylase Inhibitor, Butyroyloxymethyl-Diethyl Phosphate (AN-7), on Corneal Neovascularization in a Mouse Model. ( 28338404 )
2017

Variations for Corneal Neovascularization

Expression for Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for Corneal Neovascularization

Pathways related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
2
Show member pathways
13.61 CXCL12 FGF2 FLT1 KDR TEK TIMP2
3
Show member pathways
13.43 CXCL12 FGF2 FLT1 KDR TEK TIMP2
4
Show member pathways
13.32 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
5
Show member pathways
13.3 CD36 CXCL10 CXCL12 KDR PLG THBS1
6
Show member pathways
13.22 CXCL12 FGF2 FLT1 KDR TEK TIMP2
7
Show member pathways
13.21 CD36 HRG PLG TEK THBS1 VEGFA
8
Show member pathways
13.17 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
9
Show member pathways
13.12 CXCL12 FGF2 FLT1 KDR TEK TIMP2
10
Show member pathways
12.97 CXCL12 FGF2 FLT1 KDR TIMP2
11
Show member pathways
12.95 CXCL12 FGF2 FLT1 KDR TIMP2
12
Show member pathways
12.87 FGF2 FLT1 KDR TEK THBS1 VEGFA
13 12.68 FGF2 FLT1 KDR TEK VEGFA
14
Show member pathways
12.66 FGF2 KDR PLG THBS1 TIMP2
15
Show member pathways
12.62 CXCL12 FGF2 FLT1 KDR TIMP2
16
Show member pathways
12.52 FGF2 FLT1 KDR TEK THBS1 VEGFA
17
Show member pathways
12.32 FGF2 FLT1 KDR VEGFA
18 12.24 FGF2 KDR THBS1 VEGFA
19
Show member pathways
12.23 CXCL12 FGF2 FLT1 KDR TEK TIMP2
20
Show member pathways
12.15 FGF2 FLT1 KDR VEGFA
21
Show member pathways
12.12 CXCL12 FGF2 FLT1 KDR TIMP2
22
Show member pathways
12.04 CD36 KDR THBS1
23 12.04 FGF2 FLT1 KDR TEK
24
Show member pathways
11.99 CXCL12 FGF2 FLT1 KDR TIMP2
25 11.98 FGF2 KDR VEGFA
26 11.95 FLT1 KDR VEGFA
27
Show member pathways
11.91 FLT1 KDR VEGFA
28 11.9 CD36 FGF2 VEGFA
29 11.83 FLT1 TEK VEGFA
30
Show member pathways
11.78 FLT1 KDR VEGFA
31 11.73 CXCL12 FLT1 TEK VEGFA
32 11.6 FLT1 KDR VEGFA
33 11.44 FGF2 KDR VEGFA
34 11.38 FGF2 FLT1 KDR TEK THBS1 TIMP2
35 11.36 FGF2 KDR PLG VEGFA
36 11.25 FGF2 FLT1 KDR VEGFA
37 11.24 FLT1 KDR VEGFA
38 11.09 FGF2 FLT1 VEGFA
39 11.03 FGF2 FLT1 KDR VEGFA
40 10.95 CXCL12 FGF2 PLG THBS1
41
Show member pathways
10.81 FLT1 KDR VEGFA
42 10.78 HRG PLG
43 10.7 CXCL10 CXCL12 FGF2 FLT1 KDR TEK
44 10.48 FGF2 FLT1 KDR TEK TIMP2 VEGFA

GO Terms for Corneal Neovascularization

Cellular components related to Corneal Neovascularization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.72 HRG PLG SERPINF1 THBS1 TIMP2
2 external side of plasma membrane GO:0009897 9.71 CD36 CXCL10 CXCL12 THBS1
3 cell surface GO:0009986 9.7 CD36 HRG PLG TEK THBS1 TIMP2
4 receptor complex GO:0043235 9.67 CD36 FLT1 KDR TEK
5 extracellular space GO:0005615 9.65 CD36 CXCL10 CXCL12 FGF2 FLT1 PLG
6 platelet alpha granule lumen GO:0031093 9.56 HRG PLG THBS1 VEGFA
7 extracellular region GO:0005576 9.4 CXCL10 CXCL12 FGF2 FLT1 HRG KDR

Biological processes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.96 CD36 CXCL10 FGF2 VEGFA
2 negative regulation of gene expression GO:0010629 9.96 CD36 KDR SERPINF1 VEGFA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 CD36 FGF2 FLT1 KDR TEK
4 peptidyl-tyrosine phosphorylation GO:0018108 9.92 FGF2 FLT1 KDR TEK
5 response to hypoxia GO:0001666 9.92 CXCL12 TEK THBS1 VEGFA
6 chemotaxis GO:0006935 9.91 CXCL10 CXCL12 FGF2 FLT1 HRG
7 protein autophosphorylation GO:0046777 9.89 FLT1 KDR TEK
8 positive regulation of protein kinase B signaling GO:0051897 9.89 FGF2 TEK THBS1
9 cellular response to lipopolysaccharide GO:0071222 9.89 CD36 CXCL10 XBP1
10 negative regulation of endopeptidase activity GO:0010951 9.88 HRG SERPINF1 TIMP2
11 negative regulation of signal transduction GO:0009968 9.86 FLT1 KDR TEK
12 positive regulation of cell proliferation GO:0008284 9.86 CXCL10 CXCL12 FGF2 FLT1 KDR THBS1
13 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.85 FLT1 KDR TEK
14 positive regulation of MAPK cascade GO:0043410 9.85 CD36 FLT1 KDR TEK TIMP2
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 FLT1 KDR TEK
16 platelet degranulation GO:0002576 9.83 CD36 HRG PLG THBS1 VEGFA
17 positive regulation of MAP kinase activity GO:0043406 9.82 FGF2 FLT1 VEGFA
18 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.81 FLT1 KDR VEGFA
19 positive regulation of endothelial cell migration GO:0010595 9.8 KDR TEK THBS1 VEGFA
20 negative regulation of angiogenesis GO:0016525 9.8 CXCL10 HRG SERPINF1 TEK THBS1
21 negative regulation of blood vessel endothelial cell migration GO:0043537 9.79 FGF2 HRG THBS1
22 positive regulation of blood vessel endothelial cell migration GO:0043536 9.78 FGF2 KDR THBS1 VEGFA
23 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.77 FGF2 KDR VEGFA
24 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.77 FLT1 KDR VEGFA
25 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.76 FGF2 FLT1 TEK
26 sprouting angiogenesis GO:0002040 9.75 TEK THBS1 VEGFA
27 cell migration involved in sprouting angiogenesis GO:0002042 9.73 FGF2 KDR VEGFA
28 positive regulation of sprouting angiogenesis GO:1903672 9.72 FGF2 VEGFA
29 positive regulation of endothelial cell proliferation GO:0001938 9.72 CXCL12 FGF2 KDR TEK VEGFA
30 fibrinolysis GO:0042730 9.71 HRG PLG
31 vascular endothelial growth factor signaling pathway GO:0038084 9.71 FLT1 KDR VEGFA
32 negative regulation of endothelial cell migration GO:0010596 9.7 SERPINF1 THBS1
33 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.7 FLT1 VEGFA
34 positive regulation of monocyte chemotaxis GO:0090026 9.7 CXCL10 CXCL12
35 negative regulation of fibrinolysis GO:0051918 9.7 HRG PLG THBS1
36 angiogenesis GO:0001525 9.7 FGF2 FLT1 HRG KDR TEK VEGFA
37 endothelial cell proliferation GO:0001935 9.69 TEK XBP1
38 embryonic morphogenesis GO:0048598 9.69 FGF2 FLT1
39 positive regulation of T cell migration GO:2000406 9.69 CXCL10 CXCL12
40 induction of positive chemotaxis GO:0050930 9.68 CXCL12 VEGFA
41 positive regulation of blood coagulation GO:0030194 9.68 CD36 THBS1
42 positive regulation of phospholipase C activity GO:0010863 9.68 FGF2 FLT1
43 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
44 positive regulation of focal adhesion assembly GO:0051894 9.67 HRG KDR TEK VEGFA
45 positive regulation of axon extension involved in axon guidance GO:0048842 9.65 CXCL12 VEGFA
46 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.63 KDR VEGFA
47 negative regulation of endothelial cell chemotaxis GO:2001027 9.61 HRG THBS1
48 positive regulation of cell migration GO:0030335 9.5 CXCL10 CXCL12 FLT1 KDR THBS1 VEGFA
49 positive regulation of angiogenesis GO:0045766 9.17 FGF2 FLT1 KDR TEK THBS1 VEGFA
50 multicellular organism development GO:0007275 10.14 FGF2 FLT1 KDR SERPINF1 VEGFA XBP1

Molecular functions related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.78 CXCL10 CXCL12 HRG PLG
2 cytokine activity GO:0005125 9.71 CXCL10 CXCL12 FGF2 VEGFA
3 growth factor activity GO:0008083 9.69 CXCL12 FGF2 VEGFA
4 protein tyrosine kinase activity GO:0004713 9.56 FGF2 FLT1 KDR TEK
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.54 FLT1 KDR TEK
6 growth factor binding GO:0019838 9.5 FLT1 KDR TEK
7 transforming growth factor beta binding GO:0050431 9.49 CD36 THBS1
8 low-density lipoprotein particle binding GO:0030169 9.46 CD36 THBS1
9 vascular endothelial growth factor-activated receptor activity GO:0005021 9.43 FLT1 KDR
10 heparin binding GO:0008201 9.35 CXCL10 FGF2 HRG THBS1 VEGFA
11 integrin binding GO:0005178 9.02 CXCL12 FGF2 KDR THBS1 TIMP2
12 protein binding GO:0005515 10 CD36 CXCL10 CXCL12 FGF2 FLT1 HRG

Sources for Corneal Neovascularization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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