MCID: CRN027
MIFTS: 48

Corneal Neovascularization

Categories: Eye diseases

Aliases & Classifications for Corneal Neovascularization

MalaCards integrated aliases for Corneal Neovascularization:

Name: Corneal Neovascularization 12 55 44 15 17 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:11382
ICD9CM 35 370.6 370.60
MeSH 44 D016510
SNOMED-CT 68 19161004
ICD10 33 H16.4 H16.40
UMLS 72 C0085109

Summaries for Corneal Neovascularization

MalaCards based summary : Corneal Neovascularization is related to keratitis, hereditary and kaposi sarcoma. An important gene associated with Corneal Neovascularization is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Angiogenesis Inhibitors and Angiogenesis Modulating Agents have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and t cells, and related phenotypes are Decreased cell migration and cardiovascular system

Wikipedia : 75 Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into... more...

Related Diseases for Corneal Neovascularization

Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 31.2 VEGFA IL1B FGF2
2 kaposi sarcoma 30.1 VEGFA KDR FGF2
3 diabetic macular edema 29.9 VEGFA TEK SERPINF1 FGF2
4 retinal vascular disease 29.4 VEGFA SERPINF1 PLG KDR FLT1
5 hemangioma 29.4 VEGFA TEK KDR FLT1 FGF2
6 microvascular complications of diabetes 5 29.2 VEGFA TEK SERPINF1 KDR FLT1 FGF2
7 macular degeneration, age-related, 1 29.0 VEGFA SERPINF1 PLG KDR IL1B FLT1
8 warburg-cinotti syndrome 11.4
9 glomeruloid hemangioma 10.5 VEGFA FLT1
10 hemangioendothelioma 10.5 PLG KDR
11 vitreous detachment 10.5 VEGFA PLG
12 yemenite deaf-blind hypopigmentation syndrome 10.5
13 pyogenic granuloma 10.4 VEGFA TEK
14 angiodysplasia 10.4 VEGFA FGF2
15 corneal disease 10.4
16 kashin-beck disease 10.4 VEGFA IL1B
17 keratopathy 10.4
18 macular dystrophy, dominant cystoid 10.4 VEGFA SERPINF1
19 corneal edema 10.4
20 blood group, globoside system 10.3 VEGFA PLG
21 limbal stem cell deficiency 10.3
22 stromal keratitis 10.3
23 laryngitis 10.3 IL1B FGF2
24 radiation proctitis 10.3 VEGFA KDR FGF2
25 angiokeratoma circumscriptum 10.3 VEGFA KDR FLT1
26 cancer-associated retinopathy 10.3 VEGFA FLT1
27 breast carcinoma in situ 10.3 VEGFA FLT1 FGF2
28 skin hemangioma 10.3 VEGFA KDR FLT1
29 angiomatous meningioma 10.3 VEGFA KDR FGF2
30 epithelioid hemangioendothelioma 10.3 VEGFA KDR FLT1
31 posterior uveal melanoma 10.3 VEGFA THBS1
32 vitreous disease 10.3 VEGFA PLG FGF2
33 eye disease 10.3
34 eales disease 10.2 VEGFA SERPINF1 IL1B
35 poems syndrome 10.2 VEGFA IL1B FGF2
36 bursitis 10.2 KDR CXCL12
37 osteosclerotic myeloma 10.2 PLG IL1B
38 herpes simplex 10.2
39 placenta accreta 10.2 TEK KDR FLT1
40 endophthalmitis 10.2 VEGFA PLG
41 diabetic cataract 10.1 VEGFA SERPINF1
42 clivus chordoma 10.1 FGF2 CXCL12
43 severe cutaneous adverse reaction 10.1
44 erythema multiforme 10.1
45 corneal dystrophy 10.1
46 erythema multiforme major 10.1
47 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.1
48 nervous system disease 10.1 VEGFA PLG IL1B
49 arteriovenous malformations of the brain 10.1 VEGFA THBS1 KDR
50 triiodothyronine receptor auxiliary protein 10.0

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to Corneal Neovascularization

Symptoms & Phenotypes for Corneal Neovascularization

GenomeRNAi Phenotypes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.92 DDR2 FLT1 KDR TIMP2

MGI Mouse Phenotypes related to Corneal Neovascularization:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 CXCL10 CXCL12 DDR2 FGF2 FLT1 IL1B
2 hematopoietic system MP:0005397 10.26 CXCL10 CXCL12 FGF2 FLT1 IL1B KDR
3 homeostasis/metabolism MP:0005376 10.2 CXCL10 DDR2 FGF2 FLT1 IL1B KDR
4 cellular MP:0005384 10.15 CXCL10 CXCL12 DDR2 FGF2 FLT1 KDR
5 mortality/aging MP:0010768 10.14 CXCL10 CXCL12 DDR2 FGF2 FLT1 IL1B
6 immune system MP:0005387 10.13 CXCL10 CXCL12 FLT1 IL1B KDR PLG
7 nervous system MP:0003631 10.03 CXCL10 CXCL12 DDR2 FGF2 FLT1 IL1B
8 muscle MP:0005369 9.97 CXCL12 DDR2 FGF2 FLT1 KDR TEK
9 neoplasm MP:0002006 9.8 DDR2 FGF2 IL1B PLG THBS1 VEGFA
10 reproductive system MP:0005389 9.76 CXCL12 DDR2 FGF2 FLT1 PLG SERPINF1
11 skeleton MP:0005390 9.5 DDR2 FGF2 IL1B KDR SERPINF1 THBS1
12 vision/eye MP:0005391 9.28 DDR2 FGF2 FLT1 KDR PLG SERPINF1

Drugs & Therapeutics for Corneal Neovascularization

Drugs for Corneal Neovascularization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Angiogenesis Inhibitors Phase 4
2 Angiogenesis Modulating Agents Phase 4
3 Antineoplastic Agents, Immunological Phase 4
4 Antibodies Phase 4
5 Immunoglobulins Phase 4
6 Antibodies, Monoclonal Phase 4
7 Anesthetics Phase 4
8
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 5280972 54715139
9
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
10
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
11 Anti-Infective Agents Phase 2, Phase 3
12 Antimalarials Phase 2, Phase 3
13 Antiparasitic Agents Phase 2, Phase 3
14 Antiprotozoal Agents Phase 2, Phase 3
15 Mitogens Phase 2, Phase 3
16 Endothelial Growth Factors Phase 2, Phase 3
17 triamcinolone acetonide Phase 2, Phase 3
18 Triamcinolone hexacetonide Phase 2, Phase 3
19 Triamcinolone diacetate Phase 2, Phase 3
20
Bevacizumab Approved, Investigational Phase 2 216974-75-3
21 Cathartics Phase 1, Phase 2
22 Carboxymethylcellulose Sodium Phase 1, Phase 2
23 Laxatives Phase 1, Phase 2
24 Ophthalmic Solutions Phase 1, Phase 2
25 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
26
Ranibizumab Approved Phase 1 347396-82-1 459903
27
Zinc Approved, Investigational Phase 1 7440-66-6 32051
28
Tropicamide Approved, Investigational Phase 1 1508-75-4 5593
29
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
30
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
31 Anti-Bacterial Agents Phase 1
32 insulin Phase 1
33 Insulin, Globin Zinc Phase 1
34 Mydriatics Phase 1
35 Antibiotics, Antitubercular Phase 1
36 Hypoglycemic Agents Phase 1
37 Gentamicins Phase 1
38 Lubricant Eye Drops Phase 1
39 Betamethasone-17,21-dipropionate Phase 1
40 Betamethasone Valerate Phase 1 2152-44-5
41 Betamethasone sodium phosphate Phase 1
42 Betamethasone benzoate Phase 1
43 Antifungal Agents Phase 1
44 Immunosuppressive Agents Phase 1
45 Calcineurin Inhibitors Phase 1
46
Verteporfin Approved, Investigational 129497-78-5
47
Prednisolone phosphate Approved, Vet_approved 302-25-0
48
Methylprednisolone hemisuccinate Approved 2921-57-5
49
Methylprednisolone Approved, Vet_approved 83-43-2 6741
50
Prednisolone Approved, Vet_approved 50-24-8 5755

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Management of Active and Established Corneal Neovascularisation to Prevent Visual Impairment Unknown status NCT02594423 Phase 4 Bevacizumab
2 The Effect of Bevacizumab on Corneal Neovascularization Completed NCT00797303 Phase 4 Bevacizumab
3 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
4 Prospective, Double-blind, Randomized, Controlled Clinical Trial of Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3 Doxycycline;Placebo
5 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3 Bevacizumab (Avastin)
6 Topical/Subconjunctival Injection of Bevacizumab(Avastin) for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
7 Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization Unknown status NCT02797704 Phase 1, Phase 2 Aflibercept
8 Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose Unknown status NCT02157987 Phase 1, Phase 2 bevacuzimab spray
9 Clinical Study of Transplantation of Autologous Cultivated Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency Unknown status NCT02415218 Phase 1, Phase 2
10 Safety and Efficacy of Topical Pazopanib in Treatment of Corneal Neovascularization Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
11 Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01072357 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
12 A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01996826 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
13 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
14 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
15 Phase 2 Ziv-aflibercept in Ocular Disease Short and Long-term Study Recruiting NCT02486484 Phase 2 ziv-aflibercept
16 Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases: Phase Ib Clinical Trial Active, not recruiting NCT02739113 Phase 1, Phase 2
17 Topical IL-1-Ra for Treatment of Corneal Neovascularization Terminated NCT00915590 Phase 1, Phase 2 Placebo;IL-1Ra
18 Infliximab Therapy to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis Withdrawn NCT01256489 Phase 1, Phase 2 Infliximab
19 The Improvement of Limbal Epithelial Culture Technique for the Treatment of Unilateral Limbal Insufficiency by Using Collagenase to Isolate Limbal Stem Cells Unknown status NCT02202642 Phase 1
20 Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV) Completed NCT00681889 Phase 1 Ranibizumab
21 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00559936 Phase 1 Topical Avastin 1%
22 Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery Completed NCT00769145 Phase 1 Ranibizumab
23 Phase 1 Study of Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
24 Clinical Study: Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
25 Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases: A Clinical Study Recruiting NCT03943797 Phase 1
26 Subconjunctival Aflibercept Injection for Corneal Neovascularization Terminated NCT01868360 Phase 1 Subconjunctival aflibercept
27 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
28 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00512876 Bevacizumab (Avastin)
29 Photodynamic Therapy With Verteporfin for Corneal Neovascularization Completed NCT00471406
30 Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization Completed NCT00004430 Dihematoporphyrin derivative;prednisolone
31 The Application of Subconjunctival Injection of Bevacizumab (Avastin) in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
32 Clinical Trial Comparing Subconjunctival and Topical Bevacizumab as Adjuncts to Trabeculectomy in Improving Outcomes for Primary Open Angle Glaucoma Completed NCT01425112
33 Neovascularization Patterns in Corneal Graft Rejection Completed NCT01695655
34 Comparison Between Nylon and Polyglactin Corneal Suture in Pediatric Cataract Surgery: a Randomized Controlled Clinical Trial Recruiting NCT03812640
35 Clinical Treatment of Patients With Age-Related Macular Degeneration With Anecortave Acetate Sterile Suspension No longer available NCT00349739 Anecortave Acetate
36 Corneal Thinning During Topical Bevacizumab Therapy Withdrawn NCT00515684 bevacizumab (Avastin)

Search NIH Clinical Center for Corneal Neovascularization

Cochrane evidence based reviews: corneal neovascularization

Genetic Tests for Corneal Neovascularization

Anatomical Context for Corneal Neovascularization

MalaCards organs/tissues related to Corneal Neovascularization:

41
Endothelial, Eye, T Cells, Bone, Neutrophil, Prostate, Lung

Publications for Corneal Neovascularization

Articles related to Corneal Neovascularization:

(show top 50) (show all 1321)
# Title Authors PMID Year
1
A siRNA targeting vascular endothelial growth factor-A inhibiting experimental corneal neovascularization. 9 38
20450250 2010
2
VEGF Trap(R1R2) suppresses experimental corneal angiogenesis. 9 38
19882518 2010
3
Pterygia: pathogenesis and the role of subconjunctival bevacizumab in treatment. 9 38
19437347 2009
4
Evaluation of cytotoxic effects of bevacizumab on human corneal cells. 9 38
19387236 2009
5
Analysis of angiogenesis induced by cultured corneal and oral mucosal epithelial cell sheets in vitro. 9 38
17904552 2007
6
Inhibition of corneal neovascularization with a nutrient mixture containing lysine, proline, ascorbic acid, and green tea extract. 9 38
17845900 2007
7
Inhibition of corneal neovascularization by recombinant adenovirus-mediated sFlk-1 expression. 9 38
17692288 2007
8
[A synthetic peptide selected by bioinformatics inhibits mouse corneal neovascularization]. 9 38
17459247 2007
9
A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents. 9 38
17107753 2007
10
Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization. 9 38
17198016 2007
11
Inhibition of corneal neovascularization by rapamycin. 9 38
16672771 2006
12
Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders. 9 38
16195702 2006
13
Proteomic identification of activin receptor-like kinase-1 as a differentially expressed protein during hyaloid vascular system regression. 9 38
16223497 2005
14
Differential conversion of plasminogen to angiostatin by human corneal cell populations. 9 38
16270025 2005
15
Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo. 9 38
15851564 2005
16
Corneal neovascularization suppressed by TIMP2 released from human amniotic membranes. 9 38
17162918 2005
17
Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. 9 38
15326102 2004
18
Suppression of corneal neovascularization by PEDF release from human amniotic membranes. 9 38
15161837 2004
19
Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. 9 38
15126605 2004
20
[Suppression of corneal neovascularization by conditioned culture medium of human amniotic membrane]. 9 38
14769230 2003
21
Thrombospondins 1 and 2 function as inhibitors of angiogenesis. 9 38
12714043 2003
22
VEGF-dependent conjunctivalization of the corneal surface. 9 38
12506063 2003
23
[Expression of vascular endothelial growth factor and its receptors (flt-1) in morbid human corneas and investigation of its clinic importance]. 9 38
15515760 2002
24
Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA. 9 38
12470964 2002
25
Inhibition of prostate tumor angiogenesis by the tumor suppressor CEACAM1. 9 38
12122002 2002
26
Suppression of corneal neovascularization by culture supernatant of human amniotic cells. 9 38
11805510 2002
27
HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. 9 38
11118060 2000
28
Towards a closed eye model of the pre-ocular tear layer. 9 38
11029550 2000
29
Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas. 9 38
10937562 2000
30
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. 9 38
10202935 1999
31
Diurnal variations in angiostatin in human tear fluid: a possible role in prevention of corneal neovascularization. 9 38
10342373 1999
32
Inhibition of angiogenesis by interleukin 4. 9 38
9743522 1998
33
The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization. 9 38
9733580 1998
34
The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. 9 38
9233641 1997
35
[Inhibition of neovascularization of the eye by dietary factors exemplified by isoflavonoids]. 9 38
9156641 1997
36
Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. 9 38
8988045 1997
37
The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. 9 38
7592998 1995
38
The role of CXC chemokines as regulators of angiogenesis. 9 38
8574748 1995
39
Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor. 9 38
8927305 1995
40
Recombinant human epidermal growth factor and corneal neovascularization. 9 38
1289616 1992
41
[Pathophysiology of intraocular neovascularization]. 9 38
1707214 1990
42
Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization. 38
31090470 2019
43
Comparison of the Effects of Dovitinib and Bevacizumab on Reducing Neovascularization in an Experimental Rat Corneal Neovascularization Model. 38
31180924 2019
44
Early Penetrating Keratoplasty À Chaud May Improve Outcome in Therapy-Resistant Acanthamoeba Keratitis. 38
31317392 2019
45
In vivo effect of bevacizumab-loaded albumin nanoparticles in the treatment of corneal neovascularization. 38
31228461 2019
46
Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization. 38
31436645 2019
47
MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2. 38
31399604 2019
48
Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography. 38
30908339 2019
49
Efficacy of fumagillin bicyclohexylamine on experimental corneal neovascularization in rat model. 38
30006905 2019
50
Subconjunctival bevacizumab and argon laser photocoagulation for preexisting neovascularization following deep lamellar anterior keratoplasty. 38
31238461 2019

Variations for Corneal Neovascularization

Expression for Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for Corneal Neovascularization

Pathways related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TIMP2 SERPINF1 PLG KDR IL1B FLT1
2
Show member pathways
13.76 VEGFA TIMP2 TEK KDR IL1B FLT1
3
Show member pathways
13.63 VEGFA TIMP2 TEK KDR FLT1 FGF2
4
Show member pathways
13.59 TEK SERPINF1 KDR IL1B FLT1 DDR2
5
Show member pathways
13.46 TIMP2 TEK KDR FLT1 FGF2 DDR2
6
Show member pathways
13.45 VEGFA TIMP2 TEK KDR IL1B FLT1
7
Show member pathways
13.31 VEGFA THBS1 PLG KDR CXCL12 CXCL10
8
Show member pathways
13.25 TIMP2 TEK KDR FLT1 FGF2 DDR2
9
Show member pathways
13.2 TIMP2 TEK KDR IL1B FLT1 FGF2
10
Show member pathways
13.2 TIMP2 TEK KDR IL1B FLT1 FGF2
11
Show member pathways
13.18 VEGFA TIMP2 TEK KDR FLT1 FGF2
12
Show member pathways
12.99 TIMP2 KDR FLT1 FGF2 DDR2 CXCL12
13
Show member pathways
12.97 TIMP2 KDR FLT1 FGF2 CXCL12
14
Show member pathways
12.92 VEGFA THBS1 TEK KDR FLT1 FGF2
15 12.73 VEGFA TEK KDR IL1B FLT1 FGF2
16
Show member pathways
12.71 TIMP2 THBS1 PLG KDR FGF2 DDR2
17
Show member pathways
12.69 VEGFA THBS1 TEK KDR FLT1 FGF2
18
Show member pathways
12.64 TIMP2 KDR IL1B FLT1 FGF2 CXCL12
19
Show member pathways
12.53 VEGFA KDR IL1B FLT1
20
Show member pathways
12.51 TEK PLG IL1B FGF2
21
Show member pathways
12.34 VEGFA KDR FLT1 FGF2
22 12.25 VEGFA THBS1 KDR FGF2
23
Show member pathways
12.21 TIMP2 TEK KDR FLT1 FGF2 DDR2
24
Show member pathways
12.19 VEGFA KDR FLT1 FGF2
25
Show member pathways
12.18 TIMP2 KDR IL1B FLT1 FGF2 CXCL12
26 12.02 TEK KDR FLT1 FGF2 DDR2
27 12.01 VEGFA KDR IL1B
28
Show member pathways
12 TIMP2 KDR IL1B FLT1 FGF2 CXCL12
29 11.99 VEGFA KDR FGF2
30 11.96 VEGFA KDR FLT1
31
Show member pathways
11.92 VEGFA KDR FLT1
32 11.91 VEGFA IL1B FGF2
33 11.88 VEGFA TEK FLT1
34
Show member pathways
11.8 VEGFA KDR FLT1
35 11.64 VEGFA FGF2 DDR2
36 11.62 VEGFA TEK IL1B FLT1 CXCL12
37 11.61 VEGFA KDR FLT1
38 11.58 TIMP2 THBS1 TEK KDR FLT1 FGF2
39 11.48 VEGFA KDR FGF2
40 11.47 VEGFA PLG KDR FGF2
41 11.37 VEGFA KDR FLT1 FGF2
42 11.31 VEGFA KDR FLT1
43 11.19 VEGFA FLT1 FGF2
44 11.11 THBS1 PLG FGF2 CXCL12
45 11.1 TIMP2 IL1B
46 11.06 VEGFA KDR FLT1 FGF2
47 10.79 PLG HRG
48 10.51 TIMP2 TEK KDR IL1B FLT1 FGF2
49 10.48 VEGFA TIMP2 TEK KDR FLT1 FGF2

GO Terms for Corneal Neovascularization

Cellular components related to Corneal Neovascularization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 VEGFA TIMP2 THBS1 TEK PLG HRG
2 receptor complex GO:0043235 9.67 TEK KDR FLT1 DDR2
3 collagen-containing extracellular matrix GO:0062023 9.65 TIMP2 THBS1 SERPINF1 PLG HRG
4 extracellular space GO:0005615 9.65 VEGFA TIMP2 THBS1 SERPINF1 PLG IL1B
5 secretory granule GO:0030141 9.58 VEGFA THBS1 IL1B
6 platelet alpha granule lumen GO:0031093 9.46 VEGFA THBS1 PLG HRG
7 extracellular region GO:0005576 9.44 VEGFA TIMP2 THBS1 TEK SERPINF1 PLG

Biological processes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 VEGFA IL1B FGF2 CXCL10
2 extracellular matrix organization GO:0030198 9.96 THBS1 KDR FGF2 DDR2
3 positive regulation of protein phosphorylation GO:0001934 9.95 VEGFA TEK KDR IL1B
4 protein autophosphorylation GO:0046777 9.94 TEK KDR FLT1 DDR2
5 positive regulation of protein kinase B signaling GO:0051897 9.89 THBS1 TEK FGF2
6 platelet degranulation GO:0002576 9.89 VEGFA THBS1 PLG HRG
7 chemotaxis GO:0006935 9.89 HRG FLT1 FGF2 CXCL12 CXCL10
8 negative regulation of endopeptidase activity GO:0010951 9.88 TIMP2 SERPINF1 HRG
9 negative regulation of apoptotic process GO:0043066 9.88 VEGFA THBS1 TEK KDR
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.88 TEK KDR FLT1 DDR2
11 activation of MAPK activity GO:0000187 9.87 THBS1 IL1B FGF2
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 TEK KDR FLT1
13 angiogenesis GO:0001525 9.85 VEGFA TEK KDR HRG FLT1 FGF2
14 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.84 VEGFA KDR FLT1
15 positive regulation of MAP kinase activity GO:0043406 9.84 VEGFA FLT1 FGF2
16 peptidyl-tyrosine phosphorylation GO:0018108 9.84 TEK KDR FLT1 DDR2
17 response to hypoxia GO:0001666 9.83 VEGFA THBS1 TEK CXCL12
18 negative regulation of angiogenesis GO:0016525 9.83 THBS1 TEK SERPINF1 HRG CXCL10
19 positive regulation of cell division GO:0051781 9.82 VEGFA IL1B FGF2
20 negative regulation of blood vessel endothelial cell migration GO:0043537 9.81 THBS1 HRG FGF2
21 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.8 VEGFA KDR FGF2
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.79 VEGFA KDR FLT1
23 positive regulation of MAPK cascade GO:0043410 9.79 TIMP2 KDR FLT1
24 sprouting angiogenesis GO:0002040 9.78 VEGFA THBS1 TEK
25 positive regulation of endothelial cell migration GO:0010595 9.78 VEGFA THBS1 TEK KDR
26 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.77 TEK FLT1 FGF2
27 positive regulation of blood vessel endothelial cell migration GO:0043536 9.76 VEGFA THBS1 KDR FGF2
28 cell migration involved in sprouting angiogenesis GO:0002042 9.74 VEGFA KDR FGF2
29 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.73 VEGFA IL1B FLT1
30 vascular endothelial growth factor signaling pathway GO:0038084 9.72 VEGFA KDR FLT1
31 negative regulation of endothelial cell migration GO:0010596 9.71 THBS1 SERPINF1
32 fibrinolysis GO:0042730 9.71 PLG HRG
33 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 TEK KDR FLT1 FGF2
34 positive regulation of monocyte chemotaxis GO:0090026 9.7 CXCL12 CXCL10
35 positive regulation of T cell migration GO:2000406 9.7 CXCL12 CXCL10
36 positive regulation of cell migration GO:0030335 9.7 VEGFA THBS1 KDR IL1B FLT1 CXCL12
37 embryonic morphogenesis GO:0048598 9.69 FLT1 FGF2
38 induction of positive chemotaxis GO:0050930 9.69 VEGFA CXCL12
39 positive regulation of phospholipase C activity GO:0010863 9.69 FLT1 FGF2
40 negative regulation of fibrinolysis GO:0051918 9.69 THBS1 PLG HRG
41 positive regulation of positive chemotaxis GO:0050927 9.68 VEGFA KDR
42 positive regulation of fibroblast migration GO:0010763 9.68 THBS1 DDR2
43 positive regulation of axon extension involved in axon guidance GO:0048842 9.67 VEGFA CXCL12
44 response to peptide hormone GO:0043434 9.66 TEK CXCL12
45 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 VEGFA KDR
46 positive regulation of endothelial cell proliferation GO:0001938 9.65 VEGFA TEK KDR FGF2 CXCL12
47 negative regulation of endothelial cell chemotaxis GO:2001027 9.63 THBS1 HRG
48 positive regulation of focal adhesion assembly GO:0051894 9.62 VEGFA TEK KDR HRG
49 positive regulation of cell proliferation GO:0008284 9.61 VEGFA THBS1 KDR IL1B FLT1 FGF2
50 response to vitamin D GO:0033280 9.4 CXCL10

Molecular functions related to Corneal Neovascularization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.76 PLG HRG CXCL12 CXCL10
2 cytokine activity GO:0005125 9.72 VEGFA IL1B FGF2 CXCL12 CXCL10
3 growth factor activity GO:0008083 9.65 VEGFA FGF2 CXCL12
4 growth factor binding GO:0019838 9.58 TEK KDR FLT1
5 protein tyrosine kinase activity GO:0004713 9.56 TEK KDR FLT1 DDR2
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.46 TEK KDR FLT1 DDR2
7 vascular endothelial growth factor-activated receptor activity GO:0005021 9.43 KDR FLT1
8 heparin binding GO:0008201 9.35 VEGFA THBS1 HRG FGF2 CXCL10
9 integrin binding GO:0005178 9.1 TIMP2 THBS1 KDR IL1B FGF2 CXCL12
10 protein binding GO:0005515 10.21 VEGFA TIMP2 THBS1 TEK SERPINF1 PLG

Sources for Corneal Neovascularization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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