MCID: CRN007
MIFTS: 19

Corneal Staphyloma

Categories: Neuronal diseases

Aliases & Classifications for Corneal Staphyloma

MalaCards integrated aliases for Corneal Staphyloma:

Name: Corneal Staphyloma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12753
ICD9CM 34 371.73
SNOMED-CT 67 52476003
ICD10 32 H18.72
UMLS 71 C0152440

Summaries for Corneal Staphyloma

MalaCards based summary : Corneal Staphyloma is related to peters-plus syndrome and kabuki syndrome 1. An important gene associated with Corneal Staphyloma is DEL22Q11.2 (Chromosome 22q11.2 Deletion Syndrome, Distal), and among its related pathways/superpathways is Mineral absorption. Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Corneal Staphyloma

Diseases related to Corneal Staphyloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 peters-plus syndrome 10.3
2 kabuki syndrome 1 10.0
3 retinoblastoma 10.0
4 digeorge syndrome 10.0
5 renal hypodysplasia/aplasia 1 10.0
6 velocardiofacial syndrome 10.0
7 yemenite deaf-blind hypopigmentation syndrome 10.0
8 primary congenital glaucoma 10.0
9 sclerocornea 10.0
10 anterior segment dysgenesis 10.0
11 keratoconus 10.0
12 microphthalmia 10.0
13 microcephaly 10.0
14 congenital aphakia 10.0
15 blind hypotensive eye 10.0
16 ventricular septal defect 10.0
17 heart septal defect 10.0
18 atrial heart septal defect 10.0
19 familial retinoblastoma 10.0
20 facial cleft 10.0

Graphical network of the top 20 diseases related to Corneal Staphyloma:



Diseases related to Corneal Staphyloma

Symptoms & Phenotypes for Corneal Staphyloma

GenomeRNAi Phenotypes related to Corneal Staphyloma according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.19 RAX
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 10.19 RAX
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.19 RAX
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.19 RAX
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-159 10.19 RAX
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.19 RAX TRPV6
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 10.19 RAX
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 10.19 TRPV6
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.19 RAX
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-30 10.19 TRPV6
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 10.19 RAX
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 10.19 RAX
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 10.19 TRPV6
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.19 TRPV6
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 10.19 RAX
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-99 10.19 TRPV6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.7 TRPV6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 RAX
19 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 TRPV6
20 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.7 TRPV6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.7 RAX
22 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.7 RAX
23 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.7 TRPV6
24 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.7 RAX
25 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.7 TRPV6
26 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.7 RAX
27 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.7 TRPV6
28 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.7 RAX TRPV6
29 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.7 TRPV6
30 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.7 TRPV6
31 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.7 TRPV6
32 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 TRPV6
33 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.7 RAX
34 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.7 TRPV6
35 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 TRPV6
36 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.7 RAX TRPV6
37 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.7 RAX
38 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.7 RAX
39 Decreased nuclei size in G2M GR00096-A 8.85 WFDC1

Drugs & Therapeutics for Corneal Staphyloma

Search Clinical Trials , NIH Clinical Center for Corneal Staphyloma

Genetic Tests for Corneal Staphyloma

Anatomical Context for Corneal Staphyloma

MalaCards organs/tissues related to Corneal Staphyloma:

40
Eye

Publications for Corneal Staphyloma

Articles related to Corneal Staphyloma:

(show all 38)
# Title Authors PMID Year
1
Post-Ocular Trauma Corneal Staphyloma in a Child Living in an Underdeveloped Region of Eastern Indonesia. 61
29681830 2018
2
Congenital anterior staphyloma associated with Peters' anomaly and aphakia in a Holstein calf. 61
28529272 2017
3
George Critchett (1817-1882) and His Son George Anderson Critchett (1845-1925). 61
27815340 2017
4
Ultrasonographic characteristics of congenital corneal staphyloma. 61
27033873 2016
5
Peters anomaly in cri-du-chat syndrome. 61
26059676 2015
6
A case of 22q11.2 deletion syndrome with right microphthalmia and left corneal staphyloma. 61
23834556 2014
7
[Penetrating keratoplasty in high-risk children: prevention of graft rejection]. 61
25098116 2014
8
Anterior segment optical coherence tomography in congenital corneal opacities. 61
22959105 2012
9
Congenital corneal staphyloma as a complication of Kabuki syndrome. 61
22786791 2012
10
Prevalence of eye diseases and causes of visual impairment in school-aged children in Western China. 61
22123227 2012
11
Clinical features and surgical treatment of peripheral staphyloma. 61
21045651 2011
12
Clinical spectrum of congenital corneal staphyloma: a case report. 61
22003758 2011
13
Histopathological features in a case of peters' anomaly with acquired corneal staphyloma. 61
22606460 2011
14
A girl with Peters plus syndrome associated with myelomeningocele and chronic renal failure. 61
20424881 2010
15
[Intensive intracorneal keloid formation in a case of Peters plus syndrome and in Peters anomaly with maximum manifestation]. 61
19756642 2010
16
Congenital corneal staphyloma. 61
23198071 2009
17
Complete bilateral facial cleft (Tessier 4) with corneal staphyloma: a rare association. 61
18926197 2008
18
Congenital corneal staphyloma treated by evisceration and primary implant placement: 3 cases. 61
18204493 2008
19
[Corneal staphyloma-anterior chamber agenesia-microphakia syndrome]. 61
16485232 2006
20
Congenital corneal staphyloma associated with aphakia. 61
15206605 2004
21
Causes of blindness at the "Wiyata Guna" School for the Blind, Indonesia. 61
12928266 2003
22
Corneoscleral transplantation in congenital corneal staphyloma and Peters' anomaly. 61
12660867 2003
23
Peters' anomaly associated with protruding corneal pseudo staphyloma. 61
9520192 1998
24
Causes of removal of the eye in Ethiopia. 61
8904067 1995
25
Congenital corneal staphyloma. 61
7661758 1995
26
Childhood blindness in India: causes in 1318 blind school students in nine states. 61
8543070 1995
27
Unilateral congenital corneal staphyloma with retinal neovascularization. A case report. 61
1505761 1992
28
Balanced double complex translocations [46,XX,t(1p;6p;7p;3q;11p)(11q;22p;21q)] in an infant with multiple congenital anomalies. 61
3777028 1986
29
Congenital corneal staphyloma: clinical, radiological, and pathological correlation. 61
3718906 1986
30
Histopathologic and ultrastructural analysis of congenital corneal staphyloma. 61
6837694 1983
31
[Artificial scleral sinus with covering of recipient's cornea with cadaveric cornea for treating acute corneal staphyloma and keratoconus (author's transl)]. 61
7047884 1981
32
[Corneal staphyloma (author's transl)]. 61
6788999 1981
33
[Congenital corneal staphyloma]. 61
7418042 1980
34
[Combined congenital corneal staphyloma and Peters' malformation (recurrence of staphyloma following keratoplasty)]. 61
4582035 1972
35
[Congenital corneal staphyloma with aphakia]. 61
5072939 1972
36
[On histology and genesis of congenital corneal staphyloma]. 61
5667016 1968
37
[Corneal staphyloma with dominant heredity]. 61
13546832 1958
38
[Congenital corneal staphyloma; anatomical study]. 61
13413637 1956

Variations for Corneal Staphyloma

Expression for Corneal Staphyloma

Search GEO for disease gene expression data for Corneal Staphyloma.

Pathways for Corneal Staphyloma

Pathways related to Corneal Staphyloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.39 TRPV6 HMOX2

GO Terms for Corneal Staphyloma

Sources for Corneal Staphyloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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