Aliases & Classifications for Corneal Ulcer

MalaCards integrated aliases for Corneal Ulcer:

Name: Corneal Ulcer 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8463
ICD10 33 H16.0 H16.00
ICD9CM 35 370.0 370.00
MeSH 44 D003320
NCIt 50 C50515
SNOMED-CT 68 91514001
UMLS 73 C0010043

Summaries for Corneal Ulcer

MalaCards based summary : Corneal Ulcer is related to keratoconjunctivitis sicca and keratitis, hereditary. An important gene associated with Corneal Ulcer is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Hyaluronic acid and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Corneal ulcer is an inflammatory or more seriously, infective condition of the cornea involving... more...

Related Diseases for Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis sicca 30.1 IL1B NGF
2 keratitis, hereditary 29.8 IL1B MMP9
3 arthritis 29.7 IL1B MMP3 MMP9
4 keratoconus 29.4 MMP2 MMP3 MMP9
5 perforated corneal ulcer 12.4
6 central corneal ulcer 12.4
7 mycotic corneal ulcer 12.3
8 marginal corneal ulcer 12.3
9 ring corneal ulcer 12.3
10 dacryocystitis 11.4
11 corneal dystrophy, lattice type i 11.0
12 lymphedema-distichiasis syndrome 11.0
13 tyrosinemia, type ii 11.0
14 barre-lieou syndrome 11.0
15 ichthyosis follicularis atrichia photophobia syndrome 11.0
16 neurotrophic keratopathy 11.0
17 keratomalacia 10.8
18 keratoconjunctivitis 10.2
19 extracranial arteriovenous malformation 10.2 MMP2 MMP9
20 focal myositis 10.2 MMP2 MMP9
21 villous adenocarcinoma 10.2 MMP2 MMP9
22 lentigo maligna melanoma 10.2 MMP2 MMP9
23 psammomatous meningioma 10.2 MMP2 MMP9
24 endophthalmitis 10.2
25 acute transverse myelitis 10.2 MMP2 MMP9
26 transverse myelitis 10.2 MMP2 MMP9
27 senile ectropion 10.2 MMP2 MMP9
28 internal hemorrhoid 10.2 MMP2 MMP9
29 chronic follicular conjunctivitis 10.2 IL1B MMP9
30 ischemic colitis 10.2 MMP2 MMP9
31 light chain deposition disease 10.2 MMP2 MMP9
32 parotitis 10.2 MMP2 MMP9
33 klatskin's tumor 10.2 MMP2 MMP9
34 nasal cavity squamous cell carcinoma 10.2 MMP2 MMP9
35 odontogenic myxoma 10.2 MMP2 MMP9
36 cataract 10.2
37 chromoblastomycosis 10.2 CCR1 MMP9
38 jejunoileitis 10.2 IL1B NGF
39 laryngeal disease 10.2 MMP2 MMP9
40 paine syndrome 10.1 IL1B NGF
41 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.1
42 fungal keratitis 10.1
43 central nervous system tuberculosis 10.1 IL1B MMP9
44 hypertensive heart disease 10.1 MMP2 MMP9
45 hypopyon 10.1
46 conjunctivitis 10.1
47 aortic aneurysm, familial thoracic 1 10.1 MMP2 MMP9
48 somatoform disorder 10.1 IL1B NGF
49 pneumothorax 10.1 MMP2 MMP9
50 preterm premature rupture of the membranes 10.1 IL1B MMP9

Comorbidity relations with Corneal Ulcer via Phenotypic Disease Network (PDN):


Bullous Keratopathy Cicatricial Pemphigoid
Hypertension, Essential Hypopyon Ulcer
Perforated Corneal Ulcer Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to Corneal Ulcer

Symptoms & Phenotypes for Corneal Ulcer

MGI Mouse Phenotypes related to Corneal Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCR1 CCR3 DHX9 IL1B MMP2 MMP3
2 homeostasis/metabolism MP:0005376 9.56 CCR1 CCR3 CYP1B1 IL1B MMP2 MMP3
3 immune system MP:0005387 9.17 CCR1 CCR3 DHX9 IL1B MMP2 MMP3

Drugs & Therapeutics for Corneal Ulcer

Drugs for Corneal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 197)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22916-47-8 4189
3
Natamycin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7681-93-8 5281099
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
6
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 354812-41-2, 151096-09-2 152946
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
8
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
9
Methimazole Approved Phase 4 60-56-0 1349907
10
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
11
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
12
Propranolol Approved, Investigational Phase 4 525-66-6 4946
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
15
Amphotericin B Approved, Investigational Phase 4,Not Applicable 1397-89-3 5280965 14956
16
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83-88-5 493570
17
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
18 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Viscosupplements Phase 4
20 Adjuvants, Immunologic Phase 4
21 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
22 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
23 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
24 Anesthetics, Local Phase 4,Phase 3,Not Applicable
25 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Proxymetacaine Phase 4
27 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Not Applicable
32 Anti-Arrhythmia Agents Phase 4,Not Applicable
33 Adrenergic Agents Phase 4,Not Applicable
34 Autonomic Agents Phase 4,Phase 3,Not Applicable
35 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
36 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
38 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Antifungal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
41 Vitamin B2 Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
43 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Antiparasitic Agents Phase 4,Phase 2,Phase 3
45 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3,Phase 2
46 Methylprednisolone acetate Phase 4,Phase 3
47 Prednisolone acetate Phase 4,Phase 3
48 Analgesics Phase 4
49 Anti-Inflammatory Agents, Non-Steroidal Phase 4
50 Adrenergic beta-Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
2 Steroids for Corneal Ulcers Trial Completed NCT00324168 Phase 4 Antibiotics;Topical corticosteroid;Placebo
3 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
4 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
5 Cross-linking for Corneal Ulcers Treatment Trial Recruiting NCT02570321 Phase 4
6 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
7 Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood Unknown status NCT02153515 Phase 3
8 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3 Doxycycline;Placebo
9 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Completed NCT01794312 Phase 3
10 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Completed NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
11 Mycotic Ulcer Treatment Trial I Completed NCT00996736 Phase 3 Natamycin;Voriconazole
12 The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo Completed NCT00997035 Phase 3 Voriconazole;Placebo
13 Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients Completed NCT01809483 Phase 3
14 Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis Recruiting NCT02717871 Phase 3 Cefazolin in combination with either tobramycin or gentamicin;Cycloplegic agents (cyclopentolate 1% eye drops);Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin );Corticosteroids (prednisolone acetate 0.5% or 1% eye drops)
15 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
16 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3 povidone-iodine 1.25% ophthalmic solution;natamycin ophthalmic suspension, USP 5%
17 Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease Withdrawn NCT01753596 Phase 3
18 Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion Withdrawn NCT02483897 Phase 3 Tetracaine 0.5% ophthalmic drops;Normal Saline placebo drops
19 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2 Povidone-Iodine
20 Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers Completed NCT00651586 Phase 2 Gatifloxacin 0.3% ophthalmic solution;Ciprofloxacin 0.3% ophthalmic solution
21 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 µg/ml eye drops solution;rhNGF 20 µg/ml eye drops solution;Placebo
22 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK Completed NCT02227147 Phase 2 rhNGF 20µg/ml
23 Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer Completed NCT00557362 Phase 1, Phase 2 Natamycin 5%;Voriconazole
24 Collagen Cross-linking in Infectious Keratitis Trial Completed NCT01831206 Phase 2
25 Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye Completed NCT01393132 Phase 2 Thymosin Beta 4 eye drops;Vehicle Control
26 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis Completed NCT01582880 Phase 1, Phase 2 Riboflavin
27 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
28 Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment Recruiting NCT01765244 Phase 1, Phase 2 Anterior lamellar nanostructured artificial human cornea.
29 A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis Not yet recruiting NCT03465111 Phase 2 ACTH (adrenocorticotropic hormone) gel
30 A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers. Terminated NCT01928693 Phase 2 Besivance 0.6% Ophthalmic Suspension;Zymaxid 0.5% Ophthalmic Solution;Vigamox 0.5% Ophthalmic Solution
31 Infliximab to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TENS) Withdrawn NCT01256489 Phase 1, Phase 2 Infliximab
32 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
33 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
34 Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
35 Topical Infliximab for Sterile Corneal Melt Recruiting NCT02987686 Phase 1 Topical Infliximab
36 A Study of FPA144 Combined With Modified FOLFOX6 in Gastric/Gastroesophageal Cancer Active, not recruiting NCT03343301 Phase 1
37 Xenogenic Keratoplasty From Porcine Cornea Suspended NCT01443559 Phase 1
38 The Application of Fibrin Glue in Ocular Surface Diseases Withdrawn NCT00155402 Phase 1 tissue fibrin glue application (Tisseel)
39 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
40 Corneal Ulcer Prevention Through Health Education Unknown status NCT02284698
41 Transplantation of Acellular Corneal Matrix to Treat Corneal Ulcer Unknown status NCT01244776 Not Applicable
42 Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients Unknown status NCT00789646 Not Applicable
43 Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis Unknown status NCT02328053 Not Applicable Topical anti-fungal therapy
44 The Asia Cornea Society Infectious Keratitis Study Unknown status NCT01560208
45 Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Unknown status NCT01379833
46 Early Amniotic Membrane Transplantation in Bacterial Keratitis Unknown status NCT02716883 Not Applicable
47 Besifloxacin in Bacterial Keratitis Unknown status NCT02497365 Not Applicable Besifloxacin;Tobramycin and Cefazolin
48 Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP Unknown status NCT02826174 Not Applicable Anti-Rejection Agents;Anti-Inflammatory Agents
49 Pascal Pascal Dynamic Contour Tonometer (DCT) Intraocular Pressure and Ocular Pulse Amplitude in Patients With Thyroid Related Orbitopathy: A Comparison to Goldmann Tonometer and to Muscles Characteristics on CT Scan Unknown status NCT00646295 Not Applicable
50 Study to Evaluate the Safety and Efficacy of HI-BRITE Large Diameter Rigid Gas Permeable Contact Lens Unknown status NCT02812316 Not Applicable

Search NIH Clinical Center for Corneal Ulcer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: corneal ulcer

Genetic Tests for Corneal Ulcer

Anatomical Context for Corneal Ulcer

MalaCards organs/tissues related to Corneal Ulcer:

41
Eye, Bone, Lung, Skin, Brain, Heart, Lymph Node

Publications for Corneal Ulcer

Articles related to Corneal Ulcer:

(show top 50) (show all 345)
# Title Authors Year
1
Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size. ( 29256985 )
2018
2
Necessity to identify the causative agent for appropriate treatment in fungal corneal ulcer: an in vitro study. ( 29398639 )
2018
3
Conjunctival Hyperemia or Vasodilation and Central Corneal Ulcer in a Neonate. ( 29494721 )
2018
4
The successful treatment of a multidrug-resistant Achromobacter xylosoxidans corneal ulcer with topical meropenem. ( 30021738 )
2018
5
Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer. ( 30026985 )
2018
6
Corneal ulcer as the presenting feature of type 2 diabetes mellitus. ( 30317198 )
2018
7
Alternations of interhemispheric functional connectivity in corneal ulcer patients using voxel-mirrored homotopic connectivity: a resting state fMRI study. ( 30482026 )
2018
8
The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial. ( 28385473 )
2017
9
An unusual case of spontaneous Mycobacterium chelonae corneal ulcer in a healthy middle-aged adult [Retraction]. ( 28769591 )
2017
10
Long Eyebrow Hair Causing Corneal Ulcer. ( 29157427 )
2017
11
Severe corneal ulcer with progression to endophthalmitis and high-grade bacteremia. ( 29260050 )
2017
12
Prevention of traumatic corneal ulcer in South East Asia. ( 29849440 )
2017
13
Treatment of a Perforated Corneal Ulcer with Tectonic DSAEK: a Case Report. ( 28282693 )
2017
14
Risk of corneal ulcer in patients with end-stage renal disease: a retrospective large-scale cohort study. ( 28855193 )
2017
15
Management of a Nonhealing, Superficial Corneal Ulcer in a Hyacinth Macaw (Anodorhynchus hyacinthinus). ( 28891697 )
2017
16
Treatment Results of Corneal Collagen Cross-Linking Combined with Riboflavin and 440 Nm Blue Light for Bacterial Corneal Ulcer in Rabbits. ( 28644681 )
2017
17
CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel. ( 28644236 )
2017
18
Management of a neurotrophic deep corneal ulcer with amniotic membrane transplantation in a patient with functional monocular vision: A case report. ( 29390295 )
2017
19
Corneal ulcer due to a rare coelomycetes fungus Chaetomium strumarium: Case report and global review of Chaetomium keratomycosis. ( 28905835 )
2017
20
Corneal ulcer due to a rare pleosporalean member of the genus Bipolaris following cow tail injury to the eye: A case report and review of literature. ( 28573998 )
2017
21
Bacterial corneal ulcer associated with common variable immune deficiency. ( 27491761 )
2016
22
Fungal keratitis in patients with corneal ulcer attending Minilik II Memorial Hospital, Addis Ababa, Ethiopia. ( 27576913 )
2016
23
Rare case of bilateral perforated corneal ulcer due to gonococcal infection, managed with temporary periosteal graft. ( 26907819 )
2016
24
Corneal Ulcer Leading to Evisceration or Enucleation in a Tertiary Eye Care Center in Thailand: Clinical and Microbiological Characteristics. ( 27266225 )
2016
25
Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal. ( 27899093 )
2016
26
Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review. ( 28025573 )
2016
27
Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature. ( 27070554 )
2016
28
A Novel Tectonic Keratoplasty with Femtosecond Laser Intrastromal Lenticule for Corneal Ulcer and Perforation. ( 27453231 )
2016
29
Management of Infective Corneal Ulcer: Epidemiology Needs To Be Evaluated As Priority Basis. ( 27612884 )
2016
30
Acacia honey accelerates in vitro corneal ulcer wound healing model. ( 27473120 )
2016
31
Outcome of Urgent Penetrating Keratoplasty for Corneal Ulcer at Thammasat University Hospital. ( 27455827 )
2016
32
An unusual case of spontaneous Mycobacterium chelonae corneal ulcer in a healthy middle-aged adult. ( 27274315 )
2016
33
Complicated corneal ulcer. Case report. ( 29450359 )
2016
34
Atopic keratoconjunctivitis with corneal ulcer. Case report. ( 29450349 )
2016
35
Spontaneous Corneal Hydrops in a Patient with a Corneal Ulcer. ( 26889160 )
2016
36
Acquired anterior staphyloma after corneal ulcer associated with the use of crack. ( 27626156 )
2016
37
Bilateral sterile perforated corneal ulcer in an HIV case. ( 26265852 )
2015
38
Night market contact lens-related corneal ulcer: Should we increase public awareness? ( 26425295 )
2015
39
Community practice patterns for bacterial corneal ulcer evaluation and treatment. ( 25536529 )
2015
40
Long-term efficacy of glycerine-processed amniotic membrane transplantation in patients with corneal ulcer. ( 25773445 )
2015
41
Epidemiological Aspect and common Bacterial and Fungal isolates from Suppurative Corneal Ulcer in Mymensingh Region. ( 26007250 )
2015
42
Corneal ulcer? Think beyond only a bacterial etiology. ( 25609872 )
2015
43
Alpha-1-antitrypsin associated panniculitis and corneal ulcer with a rare allelic variant (PiFZ): a case report. ( 26474730 )
2015
44
Treatment of Acanthamoeba neurotrophic corneal ulcer with topical matrix therapy. ( 26101555 )
2015
45
Experimental study on cryotherapy for fungal corneal ulcer. ( 25880872 )
2015
46
Complementary treatment of contact lens-induced corneal ulcer using honey: A case report. ( 25278429 )
2014
47
Simultaneous study of matrix metalloproteinases, proinflammatory cytokines, and soluble cytokine receptors in the tears of noninfectious corneal ulcer patients. ( 25005620 )
2014
48
Cunninghamella spinosum fungal corneal ulcer- first case report. ( 24722275 )
2014
49
In Vitro Antibiotic Susceptibility of Pseudomonas aeruginosa Corneal Ulcer Isolates. ( 24564536 )
2014
50
Antibiotic susceptibility pattern of bacteria isolated from corneal ulcer in a tertiary level eye hospital. ( 26402978 )
2014

Variations for Corneal Ulcer

Expression for Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for Corneal Ulcer

Pathways related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CCR1 CCR3 MMP2 MMP3 MMP9
2
Show member pathways
13.06 CCR1 IL1B MMP2 MMP3 MMP9
3
Show member pathways
12.79 CCR1 CCR3 IL1B MMP9
4
Show member pathways
12.08 IL1B MMP3 MMP9
5 11.84 IL1B MMP2 MMP9
6 11.78 MMP2 MMP3 MMP9
7
Show member pathways
11.74 CCR1 CCR3 IL1B MMP2 MMP3 MMP9
8
Show member pathways
11.72 IL1B MMP2 MMP3 MMP9
9 11.71 IL1B MMP3 MMP9
10
Show member pathways
11.65 MMP2 MMP3 MMP9
11 11.61 IL1B MMP2 MMP3 MMP9
12 11.58 MMP2 MMP3 MMP9
13 11.46 IL1B MMP3 MMP9
14 11.37 MMP2 MMP3 MMP9
15 11.32 CCR1 IL1B
16 11.3 MMP2 MMP9
17 11.3 CYP1B1 IL1B
18
Show member pathways
11.26 MMP2 MMP9
19 11.19 MMP3 MMP9
20 11.12 MMP2 MMP9
21 11.09 MMP2 MMP9
22 11.06 CCR3 IL1B MMP2 MMP9
23 10.97 MMP2 MMP9
24 10.94 CCR3 IL1B MMP9
25 10.9 MMP2 MMP9
26
Show member pathways
10.72 IL1B MMP2 MMP3 MMP9

GO Terms for Corneal Ulcer

Cellular components related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.8 MMP2 MMP3 MMP9

Biological processes related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.72 CCR1 IL1B MMP9
2 inflammatory response GO:0006954 9.71 CCR1 CCR3 DHX9 IL1B
3 response to hypoxia GO:0001666 9.65 IL1B MMP2 MMP3
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.63 CCR1 CCR3 IL1B
5 positive regulation of angiogenesis GO:0045766 9.61 CCR3 CYP1B1 IL1B
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.56 MMP2 MMP9
7 positive regulation of DNA binding GO:0043388 9.54 MMP9 NGF
8 endodermal cell differentiation GO:0035987 9.52 MMP2 MMP9
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.51 CYP1B1 IL1B
10 positive regulation of interleukin-6 secretion GO:2000778 9.49 DHX9 IL1B
11 extracellular matrix disassembly GO:0022617 9.43 MMP2 MMP3 MMP9
12 regulation of defense response to virus by host GO:0050691 9.37 DHX9 IL1B
13 embryo implantation GO:0007566 9.33 IL1B MMP2 MMP9
14 regulation of neuroinflammatory response GO:0150077 9.32 MMP3 MMP9
15 collagen catabolic process GO:0030574 9.13 MMP2 MMP3 MMP9
16 cytokine-mediated signaling pathway GO:0019221 9.02 CCR1 IL1B MMP2 MMP3 MMP9

Molecular functions related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.58 MMP2 MMP3 MMP9
2 chemokine binding GO:0019956 9.37 CCR1 CCR3
3 C-C chemokine binding GO:0019957 9.32 CCR1 CCR3
4 C-C chemokine receptor activity GO:0016493 9.26 CCR1 CCR3
5 chemokine receptor activity GO:0004950 9.16 CCR1 CCR3
6 metallopeptidase activity GO:0008237 9.13 MMP2 MMP3 MMP9
7 metalloendopeptidase activity GO:0004222 8.8 MMP2 MMP3 MMP9

Sources for Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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