Aliases & Classifications for Corneal Ulcer

MalaCards integrated aliases for Corneal Ulcer:

Name: Corneal Ulcer 12 54 43 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:8463
ICD9CM 34 370.0 370.00
MeSH 43 D003320
NCIt 49 C50515
SNOMED-CT 67 91514001
ICD10 32 H16.0 H16.00
UMLS 71 C0010043

Summaries for Corneal Ulcer

MalaCards based summary : Corneal Ulcer is related to fungal keratitis and keratoconjunctivitis. An important gene associated with Corneal Ulcer is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Amphotericin B and Riboflavin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and endothelial, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Corneal ulcer is an inflammatory or, more seriously, infective condition of the cornea involving... more...

Related Diseases for Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 fungal keratitis 31.3 MMP9 CLEC7A
2 keratoconjunctivitis 30.9 NGF MUC5AC MMP9 CCL11
3 keratitis, hereditary 30.8 NGF MMP9 KRT3 KERA IL1B
4 keratoconjunctivitis sicca 30.8 PRSS21 NGF MUC5AC
5 blepharitis 30.5 MUC5AC MMP9 LACRT
6 dry eye syndrome 30.2 NGF MUC5AC LACRT
7 bronchitis 29.9 MMP9 IL1B CCR3 CCL11
8 refractive error 29.8 MMP9 MMP3 MMP2 MMP1
9 phaeohyphomycosis 29.6 CLEC7A CLEC6A
10 rheumatoid arthritis 29.5 MMP9 MMP3 MMP2 MMP1 IL1B CCR1
11 dermatitis, atopic 29.5 NGF MUC5AC IL1B CCR3 CCL11
12 corneal disease 29.1 NGF MMP9 LACRT KRT3 KERA IL1B
13 fuchs' endothelial dystrophy 29.1 KRT3 KERA FN1
14 corneal edema 28.4 MMP3 MMP1 KRT3 KERA IL1B FN1
15 keratoconus 28.2 MMP9 MMP3 MMP2 MMP1 KRT3 KERA
16 eye disease 27.9 NGF MUC5AC MMP9 MMP2 MMP1 LACRT
17 perforated corneal ulcer 12.7
18 central corneal ulcer 12.7
19 marginal corneal ulcer 12.7
20 mycotic corneal ulcer 12.7
21 ring corneal ulcer 12.7
22 mooren's ulcer 11.7
23 neurotrophic keratopathy 11.5
24 dacryocystitis 11.5
25 mitochondrial dna depletion syndrome 6 11.5
26 neuropathy, hereditary sensory and autonomic, type iia 11.3
27 corneal dystrophy, lattice type i 11.2
28 lymphedema-distichiasis syndrome 11.2
29 tyrosinemia, type ii 11.2
30 barre-lieou syndrome 11.2
31 ichthyosis follicularis atrichia photophobia syndrome 11.2
32 gastrointestinal ulceration, recurrent, with dysfunctional platelets 11.0
33 hypercarotenemia and vitamin a deficiency, autosomal dominant 11.0
34 extracranial arteriovenous malformation 10.6 MMP9 MMP2
35 rheumatoid nodulosis 10.6 MMP9 MMP3
36 focal myositis 10.6 MMP9 MMP2
37 yemenite deaf-blind hypopigmentation syndrome 10.6
38 lentigo maligna melanoma 10.5 MMP9 MMP2
39 acute transverse myelitis 10.5 MMP9 MMP2
40 transverse myelitis 10.5 MMP9 MMP2
41 hypopyon 10.5
42 nasal cavity squamous cell carcinoma 10.5 MMP9 MMP2
43 conjunctivitis 10.5
44 herpes simplex 10.4
45 endophthalmitis 10.4
46 periapical periodontitis 10.4 MMP9 MMP2 IL1B
47 mixed cell uveal melanoma 10.4 MMP9 MMP3 MMP2
48 dentin caries 10.4 MMP3 MMP2
49 adenomyosis 10.4 NGF MMP9 MMP2
50 keratopathy 10.4

Comorbidity relations with Corneal Ulcer via Phenotypic Disease Network (PDN):


Bullous Keratopathy Cicatricial Pemphigoid
Hypertension, Essential Hypopyon Ulcer
Perforated Corneal Ulcer Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to Corneal Ulcer

Symptoms & Phenotypes for Corneal Ulcer

MGI Mouse Phenotypes related to Corneal Ulcer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CCL11 CCR1 CCR3 CLEC6A CLEC7A DHX9
2 immune system MP:0005387 9.47 CCL11 CCR1 CCR3 CLEC6A CLEC7A DHX9

Drugs & Therapeutics for Corneal Ulcer

Drugs for Corneal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
2
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
3 Vitamin B2 Phase 4
4 Antiparasitic Agents Phase 4
5 Antiprotozoal Agents Phase 4
6 Liposomal amphotericin B Phase 4
7
Voriconazole Approved Phase 3 137234-62-9 71616
8
Polymyxin B Approved, Vet_approved Phase 3 1404-26-8
9
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
10
Tropicamide Approved, Investigational Phase 3 1508-75-4 5593
11
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
12
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
13 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
14
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
15
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
16
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
17
Tetracaine Approved, Vet_approved Phase 3 94-24-6 5411
18
Cefazolin Approved Phase 3 25953-19-9 656510 33255
19
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
20
Gatifloxacin Approved, Investigational Phase 3 112811-59-3 5379
21
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
22
Besifloxacin Approved Phase 3 141388-76-3
23
Polyestradiol phosphate Approved Phase 3 28014-46-2
24
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
25
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
26
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
27
Cyclopentolate Approved Phase 3 512-15-2 2905
28
Tobramycin Approved, Investigational Phase 3 32986-56-4 5496 36294
29
Ofloxacin Approved Phase 3 82419-36-1 4583
30
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
31
Natamycin Approved Phase 3 7681-93-8 5281099
32
Iodine Approved, Investigational Phase 3 7553-56-2 807
33
Povidone Approved Phase 3 9003-39-8
34
Povidone-iodine Approved Phase 3 25655-41-8
35
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
36
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
37 Central Nervous System Depressants Phase 3
38 Cytochrome P-450 CYP3A Inhibitors Phase 3
39 Steroid Synthesis Inhibitors Phase 3
40 Polymyxins Phase 3
41 Gramicidin Phase 3
42 Antibiotics, Antitubercular Phase 3
43 Cytochrome P-450 Enzyme Inhibitors Phase 3
44 Neurotransmitter Agents Phase 3
45 Anesthetics Phase 3
46 Hormone Antagonists Phase 3
47 Mydriatics Phase 3
48 Autonomic Agents Phase 3
49 Hormones Phase 3
50 Vitamins Phase 3

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Steroids for Corneal Ulcers Trial Completed NCT00324168 Phase 4 Antibiotics;Topical corticosteroid;Placebo
2 Cross-linking for Corneal Ulcers Treatment Trial Recruiting NCT02570321 Phase 4
3 Effectiveness of Corneal Accelerated Crosslinking Versus Conventional Treatment for Infectious Keratitis Unknown status NCT02865876 Phase 3
4 Fingerprick Fresh Blood for Treatment of Chronic Corneal Ulcers, Persistent Epithelial Defects and Dry Eyes Unknown status NCT02153515 Phase 3
5 Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial Unknown status NCT03230058 Phase 2, Phase 3 Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
6 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Completed NCT01794312 Phase 3
7 Mycotic Ulcer Treatment Trial Completed NCT00996736 Phase 3 Natamycin;Voriconazole
8 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Completed NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
9 Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients Completed NCT01809483 Phase 3
10 The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo Completed NCT00997035 Phase 3 Voriconazole;Placebo
11 Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for the Treatment of Infectious Keratitis Recruiting NCT02717871 Phase 3 Cefazolin in combination with either tobramycin or gentamicin;Cycloplegic agents (cyclopentolate 1% eye drops);Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin );Corticosteroids (prednisolone acetate 0.5% or 1% eye drops)
12 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3 povidone-iodine 1.25% ophthalmic solution;natamycin ophthalmic suspension, USP 5%
13 Collagen Cross-linking in Infectious Keratitis Trial Completed NCT01831206 Phase 2
14 An 8-week Phase I/II, Multicenter, Randomized, Double-masked, Vehicle Controlled Parallel Group Study to Evaluate the Safety and Efficacy of Two Doses of Recombinant Human Nerve Growth Factor in Patients With Stage 2 and 3 of NK Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 μg/ml;rhNGF 20 μg/ml
15 An 8-week Phase II, Multicenter, Randomized, Double-masked, Vehicle Controlled Parallel Group Study With a 24 or 32 Week Follow-up to Evaluate the Efficacy of rhNGF 20 µg/ml vs Vehicle in Patients With Stage 2 and 3 Neurotrophic Keratitis Completed NCT02227147 Phase 2 rhNGF 20µg/ml
16 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2 Povidone-Iodine
17 Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers Completed NCT00651586 Phase 2 Gatifloxacin 0.3% ophthalmic solution;Ciprofloxacin 0.3% ophthalmic solution
18 Evaluation and Treatment of Ocular Complications of Vaccinia Vaccination: Suitability of NP-016 Vaccinia Immune Globulin (VIG) for Sight-Threatening Conditions [VIG31] Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
19 Multicenter Clinical Trial to Evaluate the Safety and Feasibility of an Allogeneic Tissue Engineered Drug (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers Refractory to Conventional Treatment Recruiting NCT01765244 Phase 1, Phase 2 Anterior lamellar nanostructured artificial human cornea.
20 A Single-site, Single Masked, Prospective Comparison of Three Fluoroquinolone Topical Therapies (Besifloxacin 0.6% or Gatifloxacin 0.5% or Moxifloxacin 0.5%) in the Treatment of Infectious Corneal Ulcers. Terminated NCT01928693 Phase 2 Besivance 0.6% Ophthalmic Suspension;Zymaxid 0.5% Ophthalmic Solution;Vigamox 0.5% Ophthalmic Solution
21 Phase 1 Study of Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
22 Clinical Study: Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
23 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
24 Topical Infliximab for the Treatment of Sterile Corneal Melt Recruiting NCT02987686 Phase 1 Topical Infliximab
25 Phase I Study of Xenogenic Keratoplasty From Porcine Cornea in the Treatment of Infectious Corneal Ulcer Suspended NCT01443559 Phase 1
26 Phase 1 Study of Applying Fibrin Glue in Patients With Corneal Ulcer or Patients Requiring Wound Closure by Suture Withdrawn NCT00155402 Phase 1 tissue fibrin glue application (Tisseel)
27 Transplantation of Acellular Corneal Matrix to Treat Corneal Ulcer Unknown status NCT01244776
28 Corneal Ulcer Prevention Through Health Education Unknown status NCT02284698
29 Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis Unknown status NCT02328053 Topical anti-fungal therapy
30 Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP Unknown status NCT02826174 Anti-Rejection Agents;Anti-Inflammatory Agents
31 Early Amniotic Membrane Transplantation in Bacterial Keratitis Unknown status NCT02716883
32 The Asia Cornea Society Infectious Keratitis Study Unknown status NCT01560208
33 Observation on Effect of Anti--inflammatory and Inhibition of Recurrence on the Herpes Simplex Keratitis After Topical NSAIDs Administration Unknown status NCT03013959 Pranoprofen
34 Randomized Multicentric Double Blinded Study Evaluating CACICOL20 Efficiency Versus Placebo Corneal Chronic Ulcers Healing Completed NCT01242839
35 A Clinical Trial to Evaluate the Safety and Effectiveness of the Collagen-phosphorylcholine Corneal Substitutes in Patients Requiring Lamellar Keratoplasty Completed NCT02277054
36 Multicenter Study About Fusarium Keratitits in Spain 2012 to 2014 Completed NCT02984904
37 Risk for Corneal Injury in Critically Ill Patients and Effect of Nursing Interventions for Its Prevention: Randomized Controlled Trial Completed NCT02293876
38 Interventional Study to Investigate the Safety of a Combination of Amniotic Membrane and a Holder Device (AmnioClip) in the Therapy of Ocular Surface Disorders (Sutureless Amniotic Membrane Transplantation) Completed NCT02168790 Early Phase 1
39 The Application of Fibrin Glue (Tissucol Duo Quick) in External Eye Surgeries Completed NCT02138019
40 Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT01379833
41 High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM Completed NCT00388921 Vitamin A
42 Multiplex Strip PCR for Valid, Fast and Comprehensive Multi-pathogen Detection to Support the Diagnosis of Eye Infection Diseases (Endophthalmitis, Keratitis, Corneal Ulcers) From Corneal Scraping Samples Recruiting NCT04075669
43 Village Integrated Eye Workers Trial Recruiting NCT01969786
44 Corneal Collagen Crosslinking to Increase the Resistance of the Graft Used as a Support for the Boston Keratoprosthesis Type I Against Corneal Melting Recruiting NCT03041883
45 The Effect of Biscuits Containing Red Palm Oil on School Children With Vitamin A Deficiency in West and East Malaysia Recruiting NCT03256123
46 Treatment of Postoperative Discomfort/Pain and Facilitation of Corneal Reepithelialization After Photorefractive Keratectomy Not yet recruiting NCT03739255
47 Keratoconus, Corneal Diseases and Transplant Registry (KCDTR) Not yet recruiting NCT04164407
48 A Study of Infections of the Front of the Eye (Cornea) Not yet recruiting NCT04030403
49 Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients. Terminated NCT00789646
50 A Prospective Randomized Double-masked Evaluation of Treatment Duration of the UVX System for Treating Infectious Keratitis Terminated NCT00912509 riboflavin

Search NIH Clinical Center for Corneal Ulcer

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Sulfacetamide
Sulfacetamide Sodium
Sulfisoxazole Diolamine

Cochrane evidence based reviews: corneal ulcer

Genetic Tests for Corneal Ulcer

Anatomical Context for Corneal Ulcer

MalaCards organs/tissues related to Corneal Ulcer:

40
Eye, Bone, Endothelial, Heart, Skin, T Cells, Thyroid

Publications for Corneal Ulcer

Articles related to Corneal Ulcer:

(show top 50) (show all 1519)
# Title Authors PMID Year
1
The use of nerve growth factor in herpetic keratitis: a case report. 54 61
17974026 2007
2
NGF topical application in patients with corneal ulcer does not generate circulating NGF antibodies. 54 61
17512750 2007
3
[The nerve growth factor induces cutaneous ulcer healing in "non-responder" tranplanted skin]. 54 61
16801731 2006
4
Clinical application of nerve growth factor on human corneal ulcer. 54 61
12825325 2003
5
IL-4 induces eotaxin production in corneal keratocytes but not in epithelial cells. 54 61
10705225 2000
6
Surgical management of bilateral, upper and lower eyelid entropion in 27 Shar Pei dogs, using the Stades forced granulation procedure of the upper eyelid only. 61
31738860 2020
7
Case of bilateral Mooren's ulcers following filtering surgery using EX-PRESS glaucoma filtering devices. 61
31956729 2020
8
Genotyping and phylogenetic analysis of Pythium insidiosum causing human corneal ulcer. 61
31073609 2020
9
Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid. 61
32002399 2020
10
Comparison of bacterial culture results collected via direct corneal ulcer vs conjunctival fornix sampling in canine eyes with presumed bacterial ulcerative keratitis. 61
31328879 2020
11
Corneal Ulcer Treated with 0.66% Nanoemulsion Povidone-Iodine: A Case Report. 61
31974332 2020
12
Changes in corneal innervation and pain responses in fungal keratitis. 61
31956563 2020
13
Plasma rich in growth factors for the treatment of dry eye from patients with graft versus host diseases. 61
30585084 2020
14
[Orbital Amyloidosis - Comparison of Two Different Clinical Courses]. 61
31968364 2020
15
Use of four-layer porcine small intestinal submucosa alone as a scaffold for the treatment of deep corneal defects in dogs and cats: preliminary results. 61
31937546 2020
16
Epidemiology of Eye Injuries Resulting in Hospitalization, a Referral Hospital-Based Study. 61
32021063 2020
17
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. 61
31585826 2020
18
Comparison of the Clinical Efficacy of Boston Keratoprosthesis Type I and Repetitive Penetrating Keratoplasty for Refractory Keratopathy. 61
31977683 2020
19
Markedly increased ocular side effect causing severe vision deterioration after chemotherapy using new or investigational epidermal or fibroblast growth factor receptor inhibitors. 61
31918686 2020
20
The SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers. 61
31959768 2020
21
Primary Eye Care in Eastern Nepal. 61
31842661 2019
22
Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature. 61
31801779 2019
23
Novel drug delivery methods for the treatment of keratitis: moving away from surgical intervention. 61
31701781 2019
24
Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection. 61
31673582 2019
25
The use of autologous serum eye drops for the treatment of ocular surface disorders. 61
31798853 2019
26
Recent innovations with drugs in clinical trials for neurotrophic keratitis and refractory corneal ulcers. 61
31596151 2019
27
Iris biopsy to investigate feline iris hyperpigmentation. 61
31733046 2019
28
Contact lens complications among wearers in Ghana. 61
31784334 2019
29
Very late-onset flap margin corneal ulcer following laser in situ keratomileusis. 61
30982142 2019
30
Pigmented Corneal Ulcer. 61
31875106 2019
31
Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles. 61
31541710 2019
32
CNN-based diagnosis models for canine ulcerative keratitis. 61
31578338 2019
33
Atypical Keratitis Caused by Rothia Dentocariosa. 61
31580183 2019
34
Vibrio cholerae non-O1 - the first reported case of keratitis in a healthy patient. 61
31664927 2019
35
Transient extremely shallow anterior chamber caused by ciliochoroidal detachment in a patient with Mycobacterium chelonae keratitis. 61
31417974 2019
36
Conjunctiva Necrosis Following Subconjunctival Amphotericin B Injection in Fungal Keratitis. 61
31695999 2019
37
Blood-Based Treatments for Severe Dry Eye Disease: The Need of a Consensus. 61
31533289 2019
38
Contact Lens Versus Non-Contact Lens-Related Corneal Ulcers at an Academic Center. 61
31442212 2019
39
The Utility of Colistin in Multiple Drug-Resistant Pseudomonas aeruginosa Bacterial Keratitis in a Kaposi’s Sarcoma Patient 61
31486610 2019
40
Case Report: Corneal Ulceration from Bilateral Ectropion Due to Congenital Ichthyosis. 61
31479026 2019
41
Alternations of interhemispheric functional connectivity in corneal ulcer patients using voxel-mirrored homotopic connectivity: a resting state fMRI study. 61
30482026 2019
42
Cogan-Reese syndrome with Iris cyst: A novel presentation. 61
31104851 2019
43
A 3-year follow-up study of a new corneal inlay: clinical results and outcomes. 61
31446390 2019
44
Automatic Corneal Ulcer Segmentation Combining Gaussian Mixture Modeling and Otsu Method. 61
31947282 2019
45
MicroPulse™ transscleral cyclophotocoagulation in the treatment of canine glaucoma: Preliminary results (12 dogs). 61
30109763 2019
46
A case report of infectious scleritis with corneal ulcer caused by Scedosporium aurantiacum. 61
31277100 2019
47
Utility of HSV Serology for Chronic Corneal Pathology. 61
31306215 2019
48
Risk factors for orbital implant exposure after evisceration: A case control study of 93 patients. 61
31238431 2019
49
Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low-frequency fluctuation: An fMRI study. 61
31258645 2019
50
Superficial keratectomy as a treatment for non-healing corneal ulceration associated with primary corneal endothelial degeneration. 61
30365226 2019

Variations for Corneal Ulcer

Expression for Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for Corneal Ulcer

Pathways related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 MUC5AC MMP9 MMP3 MMP2 MMP1 IL1B
2
Show member pathways
13.28 MMP9 MMP3 MMP2 MMP1 FN1 CCR3
3
Show member pathways
13.21 MMP9 MMP3 MMP2 MMP1 IL1B FN1
4 12.71 MMP9 MMP2 MMP1 HEYL FN1
5
Show member pathways
12.61 MMP9 MMP3 MMP2 MMP1 FN1
6
Show member pathways
12.29 MUC5AC IL1B CLEC7A CLEC6A
7
Show member pathways
12.13 MUC5AC MMP9 MMP3 MMP1 IL1B CCL11
8
Show member pathways
11.87 MMP9 MMP3 MMP2 IL1B FN1
9 11.78 MMP2 IL1B FN1
10 11.74 MMP3 MMP1 IL1B
11
Show member pathways
11.73 MMP9 MMP3 MMP2 MMP1
12 11.72 MMP9 MMP3 MMP2
13 11.61 MMP9 MMP2 MMP1
14 11.56 MMP9 MMP3 IL1B CCL11
15
Show member pathways
11.45 MMP9 MMP3 MMP2 MMP1 IL1B
16 11.4 MMP9 MMP2 FN1
17 11.35 MMP9 MMP2 IL1B CCR3 CCL11
18 11.28 MMP9 MMP3 MMP1
19 11.22 MMP9 MMP3 MMP2 MMP1 IL1B FN1
20 11.18 MMP9 MMP2 MMP1
21 11.14 MMP9 MMP3 MMP2 MMP1 FN1
22 11.03 MMP9 IL1B CCR3

GO Terms for Corneal Ulcer

Cellular components related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 PRSS21 NGF MUC5AC MMP9 MMP3 MMP2
2 Golgi lumen GO:0005796 9.43 NGF MUC5AC KERA
3 extracellular matrix GO:0031012 9.43 MMP9 MMP3 MMP2 MMP1 KERA FN1
4 extracellular region GO:0005576 9.4 PRSS21 NGF MUC5AC MMP9 MMP3 MMP2

Biological processes related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.8 IL1B CYP1B1 CCR3 CCL11
2 positive regulation of cell migration GO:0030335 9.8 MMP9 IL1B CLEC7A CCR1 CCL11
3 inflammatory response GO:0006954 9.8 IL1B DHX9 CLEC7A CCR3 CCR1 CCL11
4 extracellular matrix organization GO:0030198 9.77 MMP9 MMP3 MMP2 MMP1 FN1
5 calcium-mediated signaling GO:0019722 9.72 LACRT CCR3 CCR1
6 chemokine-mediated signaling pathway GO:0070098 9.7 CCR3 CCR1 CCL11
7 embryo implantation GO:0007566 9.65 MMP9 MMP2 IL1B
8 positive regulation of protein complex assembly GO:0031334 9.63 MMP3 MMP1 CLEC7A
9 endodermal cell differentiation GO:0035987 9.61 MMP9 MMP2 FN1
10 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.58 IL1B CLEC7A
11 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.57 IL1B CLEC7A
12 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.56 IL1B CLEC7A
13 regulation of neuroinflammatory response GO:0150077 9.54 MMP9 MMP3
14 regulation of defense response to virus by host GO:0050691 9.51 IL1B DHX9
15 extracellular matrix disassembly GO:0022617 9.46 MMP9 MMP3 MMP2 MMP1
16 response to amyloid-beta GO:1904645 9.43 MMP9 MMP3 MMP2
17 collagen catabolic process GO:0030574 9.26 MMP9 MMP3 MMP2 MMP1
18 cytokine-mediated signaling pathway GO:0019221 9.23 MMP9 MMP3 MMP2 MMP1 IL1B FN1

Molecular functions related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.77 PRSS21 MMP9 MMP3 MMP2 MMP1
2 endopeptidase activity GO:0004175 9.5 MMP9 MMP3 MMP1
3 metallopeptidase activity GO:0008237 9.46 MMP9 MMP3 MMP2 MMP1
4 collagen binding GO:0005518 9.43 MMP9 LACRT FN1
5 metalloendopeptidase activity GO:0004222 9.26 MMP9 MMP3 MMP2 MMP1
6 serine-type endopeptidase activity GO:0004252 9.02 PRSS21 MMP9 MMP3 MMP2 MMP1

Sources for Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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