Aliases & Classifications for Corneal Ulcer

MalaCards integrated aliases for Corneal Ulcer:

Name: Corneal Ulcer 12 56 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8463
ICD9CM 36 370.0 370.00
MeSH 45 D003320
NCIt 51 C50515
SNOMED-CT 69 91514001
ICD10 34 H16.0 H16.00
UMLS 74 C0010043

Summaries for Corneal Ulcer

MalaCards based summary : Corneal Ulcer is related to keratitis, hereditary and keratoconjunctivitis sicca. An important gene associated with Corneal Ulcer is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Miconazole and Natamycin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Corneal ulcer is an inflammatory or more seriously, infective condition of the cornea involving... more...

Related Diseases for Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 30.5 IL1B MMP9
2 keratoconjunctivitis sicca 30.2 IL1B NGF
3 arthritis 29.6 IL1B MMP3 MMP9
4 perforated corneal ulcer 12.4
5 mycotic corneal ulcer 12.4
6 central corneal ulcer 12.4
7 marginal corneal ulcer 12.4
8 ring corneal ulcer 12.4
9 dacryocystitis 11.4
10 corneal dystrophy, lattice type i 11.1
11 lymphedema-distichiasis syndrome 11.1
12 tyrosinemia, type ii 11.1
13 barre-lieou syndrome 11.1
14 ichthyosis follicularis atrichia photophobia syndrome 11.1
15 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.1
16 neurotrophic keratopathy 11.1
17 keratomalacia 10.9
18 extracranial arteriovenous malformation 10.3 MMP2 MMP9
19 focal myositis 10.3 MMP2 MMP9
20 villous adenocarcinoma 10.3 MMP2 MMP9
21 lentigo maligna melanoma 10.3 MMP2 MMP9
22 psammomatous meningioma 10.3 MMP2 MMP9
23 acute transverse myelitis 10.3 MMP2 MMP9
24 transverse myelitis 10.3 MMP2 MMP9
25 senile ectropion 10.3 MMP2 MMP9
26 internal hemorrhoid 10.3 MMP2 MMP9
27 ischemic colitis 10.3 MMP2 MMP9
28 chronic follicular conjunctivitis 10.3 IL1B MMP9
29 light chain deposition disease 10.3 MMP2 MMP9
30 parotitis 10.3 MMP2 MMP9
31 klatskin's tumor 10.3 MMP2 MMP9
32 nasal cavity squamous cell carcinoma 10.3 MMP2 MMP9
33 odontogenic myxoma 10.3 MMP2 MMP9
34 keratoconjunctivitis 10.3
35 chromoblastomycosis 10.2 CCR1 MMP9
36 jejunoileitis 10.2 IL1B NGF
37 newcastle disease 10.2 MMP2 MMP9
38 laryngeal disease 10.2 MMP2 MMP9
39 paine syndrome 10.2 IL1B NGF
40 endophthalmitis 10.2
41 central nervous system tuberculosis 10.2 IL1B MMP9
42 hypertensive heart disease 10.2 MMP2 MMP9
43 cataract 10.2
44 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.2
45 fungal keratitis 10.2
46 somatoform disorder 10.1 IL1B NGF
47 conjunctival nevus 10.1 MMP2 MMP9 NGF
48 hypopyon 10.1
49 conjunctivitis 10.1
50 mycetoma 10.1 CYP1B1 MMP9

Comorbidity relations with Corneal Ulcer via Phenotypic Disease Network (PDN):


Bullous Keratopathy Cicatricial Pemphigoid
Hypertension, Essential Hypopyon Ulcer
Perforated Corneal Ulcer Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to Corneal Ulcer

Symptoms & Phenotypes for Corneal Ulcer

MGI Mouse Phenotypes related to Corneal Ulcer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCR1 CCR3 DHX9 IL1B MMP2 MMP3
2 homeostasis/metabolism MP:0005376 9.56 CCR1 CCR3 CYP1B1 IL1B MMP2 MMP3
3 immune system MP:0005387 9.17 CCR1 CCR3 DHX9 IL1B MMP2 MMP3

Drugs & Therapeutics for Corneal Ulcer

Drugs for Corneal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 194)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22916-47-8 4189
2
Natamycin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7681-93-8 5281099
3
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 354812-41-2, 151096-09-2 152946
4
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
8
Methimazole Approved Phase 4 60-56-0 1349907
9
Propranolol Approved, Investigational Phase 4 525-66-6 4946
10
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
11
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
14
Amphotericin B Approved, Investigational Phase 4,Not Applicable 1397-89-3 5280965 14956
15
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
16
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83-88-5 493570
17
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
18 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Not Applicable
19 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 Antifungal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
25 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
26 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
28 Vitamin B2 Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Antiparasitic Agents Phase 4,Phase 2,Phase 3
30 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
32 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
33 Methylprednisolone Acetate Phase 4,Phase 3
34 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3,Phase 2
35 Prednisolone acetate Phase 4,Phase 3
36 Adrenergic Agents Phase 4,Not Applicable
37 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
38 Antihypertensive Agents Phase 4
39 Sympatholytics Phase 4
40 Cyclooxygenase Inhibitors Phase 4
41 Adrenergic beta-Antagonists Phase 4
42 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Vasodilator Agents Phase 4
44 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
45 Analgesics, Non-Narcotic Phase 4
46 Adrenergic beta-1 Receptor Antagonists Phase 4
47 Analgesics Phase 4
48 Anti-Inflammatory Agents, Non-Steroidal Phase 4
49 Adrenergic Antagonists Phase 4
50 Anti-Arrhythmia Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 71)
# Name Status NCT ID Phase Drugs
1 Steroids for Corneal Ulcers Trial Completed NCT00324168 Phase 4 Antibiotics;Topical corticosteroid;Placebo
2 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
3 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
4 Cross-linking for Corneal Ulcers Treatment Trial Recruiting NCT02570321 Phase 4
5 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
6 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
7 Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood Unknown status NCT02153515 Phase 3
8 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3 Doxycycline;Placebo
9 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Completed NCT01794312 Phase 3
10 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Completed NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
11 Mycotic Ulcer Treatment Trial I Completed NCT00996736 Phase 3 Natamycin;Voriconazole
12 The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo Completed NCT00997035 Phase 3 Voriconazole;Placebo
13 Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients Completed NCT01809483 Phase 3
14 Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis Recruiting NCT02717871 Phase 3 Cefazolin in combination with either tobramycin or gentamicin;Cycloplegic agents (cyclopentolate 1% eye drops);Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin );Corticosteroids (prednisolone acetate 0.5% or 1% eye drops)
15 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 3 Infliximab;Cyclophosphamide
16 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3 povidone-iodine 1.25% ophthalmic solution;natamycin ophthalmic suspension, USP 5%
17 Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease Withdrawn NCT01753596 Phase 3
18 Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion Withdrawn NCT02483897 Phase 3 Tetracaine 0.5% ophthalmic drops;Normal Saline placebo drops
19 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2 Povidone-Iodine
20 Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers Completed NCT00651586 Phase 2 Gatifloxacin 0.3% ophthalmic solution;Ciprofloxacin 0.3% ophthalmic solution
21 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 µg/ml eye drops solution;rhNGF 20 µg/ml eye drops solution;Placebo
22 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK Completed NCT02227147 Phase 2 rhNGF 20µg/ml
23 Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer Completed NCT00557362 Phase 1, Phase 2 Natamycin 5%;Voriconazole
24 Collagen Cross-linking in Infectious Keratitis Trial Completed NCT01831206 Phase 2
25 Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye Completed NCT01393132 Phase 2 Thymosin Beta 4 eye drops;Vehicle Control
26 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis Completed NCT01582880 Phase 1, Phase 2 Riboflavin
27 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
28 Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment Recruiting NCT01765244 Phase 1, Phase 2 Anterior lamellar nanostructured artificial human cornea.
29 A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers. Terminated NCT01928693 Phase 2 Besivance 0.6% Ophthalmic Suspension;Zymaxid 0.5% Ophthalmic Solution;Vigamox 0.5% Ophthalmic Solution
30 Infliximab to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TENS) Withdrawn NCT01256489 Phase 1, Phase 2 Infliximab
31 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
32 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
33 Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
34 Topical Infliximab for Sterile Corneal Melt Recruiting NCT02987686 Phase 1 Topical Infliximab
35 A Study of FPA144 Combined With Modified FOLFOX6 in Gastric/Gastroesophageal Cancer Active, not recruiting NCT03343301 Phase 1
36 Xenogenic Keratoplasty From Porcine Cornea Suspended NCT01443559 Phase 1
37 The Application of Fibrin Glue in Ocular Surface Diseases Withdrawn NCT00155402 Phase 1 tissue fibrin glue application (Tisseel)
38 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
39 Corneal Ulcer Prevention Through Health Education Unknown status NCT02284698
40 Transplantation of Acellular Corneal Matrix to Treat Corneal Ulcer Unknown status NCT01244776 Not Applicable
41 Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis Unknown status NCT02328053 Not Applicable Topical anti-fungal therapy
42 The Asia Cornea Society Infectious Keratitis Study Unknown status NCT01560208
43 Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Unknown status NCT01379833
44 Early Amniotic Membrane Transplantation in Bacterial Keratitis Unknown status NCT02716883 Not Applicable
45 Besifloxacin in Bacterial Keratitis Unknown status NCT02497365 Not Applicable Besifloxacin;Tobramycin and Cefazolin
46 Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP Unknown status NCT02826174 Not Applicable Anti-Rejection Agents;Anti-Inflammatory Agents
47 Pascal Pascal Dynamic Contour Tonometer (DCT) Intraocular Pressure and Ocular Pulse Amplitude in Patients With Thyroid Related Orbitopathy: A Comparison to Goldmann Tonometer and to Muscles Characteristics on CT Scan Unknown status NCT00646295 Not Applicable
48 Study to Evaluate the Safety and Efficacy of HI-BRITE Large Diameter Rigid Gas Permeable Contact Lens Unknown status NCT02812316 Not Applicable
49 Spectral-domain Optical Coherence Tomography of the Eye Unknown status NCT02614625
50 Randomized Double Blinded Study Evaluating CACICOL20 Efficiency Versus Placebo Corneal Chronic Ulcers Healing Completed NCT01242839 Not Applicable

Search NIH Clinical Center for Corneal Ulcer

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: corneal ulcer

Genetic Tests for Corneal Ulcer

Anatomical Context for Corneal Ulcer

MalaCards organs/tissues related to Corneal Ulcer:

42
Eye, Bone, Thyroid, Liver, Testes, Heart, Lymph Node

Publications for Corneal Ulcer

Articles related to Corneal Ulcer:

(show top 50) (show all 355)
# Title Authors Year
1
Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty in Eyes with Perforated Infectious Corneal Ulcer ( 31055888 )
2019
2
Genotyping and phylogenetic analysis of Pythium insidiosum causing human corneal ulcer. ( 31073609 )
2019
3
Efficacy and Safety of Amphotericin B with Autologous Serum for Fungal Corneal Ulcer. ( 30700351 )
2019
4
Successful treatment of Fusarium solani anterior chamber involvement secondary to contact lens associated corneal ulcer with intracameral Amphotericin B. ( 30828513 )
2019
5
Chronic corneal ulcer in an infant secondary to congenital corneal anesthesia due to a neurovascular conflict. ( 30857802 )
2019
6
A Middle-Aged Man With Alcoholism and a Nonhealing Corneal Ulcer. ( 30869770 )
2019
7
Very late-onset flap margin corneal ulcer following laser in situ keratomileusis. ( 30982142 )
2019
8
Conjunctival Hyperemia or Vasodilation and Central Corneal Ulcer in a Neonate. ( 29494721 )
2018
9
Risk of corneal ulcer in patients with end-stage renal disease: a retrospective large-scale cohort study. ( 28855193 )
2018
10
Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size. ( 29256985 )
2018
11
Necessity to identify the causative agent for appropriate treatment in fungal corneal ulcer: an in vitro study. ( 29398639 )
2018
12
The successful treatment of a multidrug-resistant Achromobacter xylosoxidans corneal ulcer with topical meropenem. ( 30021738 )
2018
13
Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer. ( 30026985 )
2018
14
Corneal ulcer as the presenting feature of type 2 diabetes mellitus. ( 30317198 )
2018
15
Alternations of interhemispheric functional connectivity in corneal ulcer patients using voxel-mirrored homotopic connectivity: a resting state fMRI study. ( 30482026 )
2018
16
Use of equine amniotic membrane free-island grafts for treatment of a midstromal corneal ulcer and descemetocele in a snow leopard (Panthera uncia). ( 30668260 )
2018
17
Povidone-iodine concentration and in vitro killing time of bacterial corneal ulcer isolates. ( 30800010 )
2018
18
Profile of Corneal Ulcer in a Month of harvesting Season in a Tertiary Level Eye Hospital of Eastern Nepal. ( 31056574 )
2018
19
Treatment of a Perforated Corneal Ulcer with Tectonic DSAEK: a Case Report. ( 28282693 )
2017
20
The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial. ( 28385473 )
2017
21
Corneal ulcer due to a rare pleosporalean member of the genus Bipolaris following cow tail injury to the eye: A case report and review of literature. ( 28573998 )
2017
22
CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel. ( 28644236 )
2017
23
Treatment Results of Corneal Collagen Cross-Linking Combined with Riboflavin and 440 Nm Blue Light for Bacterial Corneal Ulcer in Rabbits. ( 28644681 )
2017
24
An unusual case of spontaneous Mycobacterium chelonae corneal ulcer in a healthy middle-aged adult [Retraction]. ( 28769591 )
2017
25
Management of a Nonhealing, Superficial Corneal Ulcer in a Hyacinth Macaw (Anodorhynchus hyacinthinus). ( 28891697 )
2017
26
Corneal ulcer due to a rare coelomycetes fungus Chaetomium strumarium: Case report and global review of Chaetomium keratomycosis. ( 28905835 )
2017
27
Long Eyebrow Hair Causing Corneal Ulcer. ( 29157427 )
2017
28
Severe corneal ulcer with progression to endophthalmitis and high-grade bacteremia. ( 29260050 )
2017
29
Management of a neurotrophic deep corneal ulcer with amniotic membrane transplantation in a patient with functional monocular vision: A case report. ( 29390295 )
2017
30
Prevention of traumatic corneal ulcer in South East Asia. ( 29849440 )
2017
31
Atopic keratoconjunctivitis with corneal ulcer. Case report. ( 29450349 )
2016
32
Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature. ( 27070554 )
2016
33
Alpha-1-antitrypsin associated panniculitis and corneal ulcer with a rare allelic variant (PiFZ): a case report. ( 26474730 )
2016
34
Spontaneous Corneal Hydrops in a Patient with a Corneal Ulcer. ( 26889160 )
2016
35
Rare case of bilateral perforated corneal ulcer due to gonococcal infection, managed with temporary periosteal graft. ( 26907819 )
2016
36
Corneal Ulcer Leading to Evisceration or Enucleation in a Tertiary Eye Care Center in Thailand: Clinical and Microbiological Characteristics. ( 27266225 )
2016
37
An unusual case of spontaneous Mycobacterium chelonae corneal ulcer in a healthy middle-aged adult. ( 27274315 )
2016
38
A Novel Tectonic Keratoplasty with Femtosecond Laser Intrastromal Lenticule for Corneal Ulcer and Perforation. ( 27453231 )
2016
39
Outcome of Urgent Penetrating Keratoplasty for Corneal Ulcer at Thammasat University Hospital. ( 27455827 )
2016
40
Acacia honey accelerates in vitro corneal ulcer wound healing model. ( 27473120 )
2016
41
Bacterial corneal ulcer associated with common variable immune deficiency. ( 27491761 )
2016
42
Fungal keratitis in patients with corneal ulcer attending Minilik II Memorial Hospital, Addis Ababa, Ethiopia. ( 27576913 )
2016
43
Management of Infective Corneal Ulcer: Epidemiology Needs To Be Evaluated As Priority Basis. ( 27612884 )
2016
44
Acquired anterior staphyloma after corneal ulcer associated with the use of crack. ( 27626156 )
2016
45
Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal. ( 27899093 )
2016
46
Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review. ( 28025573 )
2016
47
Complicated corneal ulcer. Case report. ( 29450359 )
2016
48
Community practice patterns for bacterial corneal ulcer evaluation and treatment. ( 25536529 )
2015
49
Corneal ulcer? Think beyond only a bacterial etiology. ( 25609872 )
2015
50
Long-term efficacy of glycerine-processed amniotic membrane transplantation in patients with corneal ulcer. ( 25773445 )
2015

Variations for Corneal Ulcer

Expression for Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for Corneal Ulcer

Pathways related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CCR1 CCR3 MMP2 MMP3 MMP9
2
Show member pathways
13.06 CCR1 IL1B MMP2 MMP3 MMP9
3
Show member pathways
12.7 CCR1 CCR3 IL1B MMP9
4
Show member pathways
12.08 IL1B MMP3 MMP9
5 11.84 IL1B MMP2 MMP9
6 11.78 MMP2 MMP3 MMP9
7
Show member pathways
11.74 CCR1 CCR3 IL1B MMP2 MMP3 MMP9
8
Show member pathways
11.72 IL1B MMP2 MMP3 MMP9
9 11.71 IL1B MMP3 MMP9
10
Show member pathways
11.65 MMP2 MMP3 MMP9
11 11.61 IL1B MMP2 MMP3 MMP9
12 11.58 MMP2 MMP3 MMP9
13 11.46 IL1B MMP3 MMP9
14 11.37 MMP2 MMP3 MMP9
15 11.32 CCR1 IL1B
16 11.3 MMP2 MMP9
17 11.3 CYP1B1 IL1B
18
Show member pathways
11.26 MMP2 MMP9
19 11.19 MMP3 MMP9
20 11.12 MMP2 MMP9
21 11.09 MMP2 MMP9
22 11.06 CCR3 IL1B MMP2 MMP9
23 10.97 MMP2 MMP9
24 10.94 CCR3 IL1B MMP9
25 10.9 MMP2 MMP9
26
Show member pathways
10.72 IL1B MMP2 MMP3 MMP9

GO Terms for Corneal Ulcer

Cellular components related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.8 MMP2 MMP3 MMP9

Biological processes related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.72 CCR1 IL1B MMP9
2 inflammatory response GO:0006954 9.71 CCR1 CCR3 DHX9 IL1B
3 positive regulation of angiogenesis GO:0045766 9.61 CCR3 CYP1B1 IL1B
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.56 MMP2 MMP9
5 positive regulation of DNA binding GO:0043388 9.54 MMP9 NGF
6 endodermal cell differentiation GO:0035987 9.52 MMP2 MMP9
7 positive regulation of vascular endothelial growth factor production GO:0010575 9.51 CYP1B1 IL1B
8 positive regulation of interleukin-6 secretion GO:2000778 9.49 DHX9 IL1B
9 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 CCR1 CCR3
10 extracellular matrix disassembly GO:0022617 9.43 MMP2 MMP3 MMP9
11 regulation of defense response to virus by host GO:0050691 9.37 DHX9 IL1B
12 embryo implantation GO:0007566 9.33 IL1B MMP2 MMP9
13 regulation of neuroinflammatory response GO:0150077 9.32 MMP3 MMP9
14 response to hypoxia GO:0001666 9.18 MMP2
15 collagen catabolic process GO:0030574 9.13 MMP2 MMP3 MMP9
16 cytokine-mediated signaling pathway GO:0019221 9.02 CCR1 IL1B MMP2 MMP3 MMP9

Molecular functions related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.58 MMP2 MMP3 MMP9
2 chemokine binding GO:0019956 9.37 CCR1 CCR3
3 C-C chemokine binding GO:0019957 9.32 CCR1 CCR3
4 C-C chemokine receptor activity GO:0016493 9.26 CCR1 CCR3
5 chemokine receptor activity GO:0004950 9.16 CCR1 CCR3
6 metallopeptidase activity GO:0008237 9.13 MMP2 MMP3 MMP9
7 metalloendopeptidase activity GO:0004222 8.8 MMP2 MMP3 MMP9

Sources for Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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41 LOVD
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
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75 UMLS via Orphanet
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