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MCID: CRN006
MIFTS: 41

Coronary Aneurysm

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Coronary Aneurysm

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MalaCards integrated aliases for Coronary Aneurysm:

Name: Coronary Aneurysm 12 44 15 17 70
Arteriovenous Aneurysm of Coronary Vessels 12
Aneurysmal Lesion of Coronary Artery 12
Aneurysm of Coronary Vessels 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3362
ICD9CM 34 414.11
MeSH 44 D003323
NCIt 50 C168176
SNOMED-CT 67 50570003
ICD10 32 I25.41
UMLS 70 C0010051
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Summaries for Coronary Aneurysm

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MalaCards based summary : Coronary Aneurysm, also known as arteriovenous aneurysm of coronary vessels, is related to coronary stenosis and cardiogenic shock. An important gene associated with Coronary Aneurysm is ITPKC (Inositol-Trisphosphate 3-Kinase C), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Transcriptional misregulation in cancer. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and t cells, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Coronary Aneurysm

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Diseases related to Coronary Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 598)
# Related Disease Score Top Affiliating Genes
1 coronary stenosis 30.7 IL6 CRP ALB
2 cardiogenic shock 30.5 TNF IL6
3 hemopericardium 30.3 PLG CRP
4 pericardial effusion 30.3 IL6 GPT CRP ALB
5 cardiac tamponade 30.2 PLG CRP ALB
6 acute myocardial infarction 30.0 PLG MMP9 IL6 CRP
7 polyarteritis nodosa 30.0 IL6 GPT CRP
8 hyperthyroidism 30.0 GPT CRP ALB
9 thrombocytosis 29.9 IL6 CRP ALB
10 intermediate coronary syndrome 29.9 PLG IL6 CRP
11 lyme disease 29.9 TNF MMP9 IL6 CRP
12 connective tissue disease 29.9 TNF MMP3 IL6 CRP ALB
13 pericarditis 29.8 TNF IL6 CRP ALB
14 behcet syndrome 29.7 TNF IL6 CRP ALB
15 endocarditis 29.7 TNF IL6 FCGR2A CRP ALB
16 kawasaki disease 29.7 TNF MMP9 MMP3 ITPKC IL6 GPT
17 infective endocarditis 29.7 TNF IL6 FCGR2A CRP
18 rheumatic fever 29.7 TNF IL6 FCGR2A ALB
19 aortic dissection 29.7 MMP9 IL6 CRP
20 syphilis 29.6 TNF IL6 GPT CRP ALB
21 exanthem 29.6 TNF IL6 GPT CRP ALB
22 familial hypercholesterolemia 29.5 TNF MMP9 IL6 GPT CRP ALB
23 myocardial infarction 29.2 TNF PLG MMP9 MMP3 IL6 GPT
24 atrial heart septal defect 29.1 PLG CRP ALB
25 systemic lupus erythematosus 29.1 TNF MMP9 MMP3 IL6 FCGR2A CRP
26 aortic aneurysm, familial abdominal, 1 28.9 TNF PLG MMP9 MMP3 IL6 CRP
27 rheumatoid arthritis 28.4 TNF PRRC2A MMP9 MMP3 IL6 FSTL1
28 hypertension, essential 28.3 TNF PLG MMP9 MMP3 IL6 GPT
29 coronary artery aneurysm 11.3
30 congenital coronary artery aneurysm 11.2
31 aneurysm 11.0
32 chronic duodenal ileus 10.4 CRP ALB
33 dipetalonemiasis 10.4 GPT ALB
34 uvulitis 10.4 GPT CRP
35 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
36 heterophyiasis 10.4 GPT ALB
37 afferent loop syndrome 10.4 GPT ALB
38 emphysematous cholecystitis 10.4 GPT CRP
39 gummatous syphilis 10.4 GPT CRP
40 viral laryngitis 10.4 GPT CRP
41 peptic ulcer perforation 10.4 CRP ALB
42 ankylosing spondylitis 3 10.4 CRP ALB
43 anterior scleritis 10.4 TNF CRP
44 rheumatoid arthritis interstitial lung disease 10.4 TNF CRP
45 posterior scleritis 10.4 TNF CRP
46 tuberculous peritonitis 10.4 CRP ALB
47 epidural abscess 10.4 CRP ALB
48 thrombosis 10.4
49 tinea unguium 10.4 GPT CRP
50 skeletal tuberculosis 10.4 TNF CRP

Graphical network of the top 20 diseases related to Coronary Aneurysm:



Diseases related to Coronary Aneurysm
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Symptoms & Phenotypes for Coronary Aneurysm

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MGI Mouse Phenotypes related to Coronary Aneurysm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 ABHD16A BLK FCGR2A IL6 ITPKC MMP3
2 immune system MP:0005387 9.4 ABHD16A ALB BLK CRP FCGR2A IL6
Sources

Drugs & Therapeutics for Coronary Aneurysm

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Drugs for Coronary Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
3 Analgesics, Non-Narcotic Phase 4
4 Fibrinolytic Agents Phase 4
5 Cyclooxygenase Inhibitors Phase 4
6 Antirheumatic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Analgesics Phase 4
9 Antipyretics Phase 4
10 Platelet Aggregation Inhibitors Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Neurotransmitter Agents Phase 4
13 Purinergic P2Y Receptor Antagonists Phase 4
14
Atorvastatin Approved Phase 2 134523-00-5 60823
15
Infliximab Approved Phase 2 170277-31-3
16
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
17 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
18 Antimetabolites Phase 2
19 Lipid Regulating Agents Phase 2
20 Anticholesteremic Agents Phase 2
21 Hypolipidemic Agents Phase 2
22 Immunoglobulins Phase 2
23 Antibodies Phase 2
24 Immunoglobulins, Intravenous Phase 2
25 gamma-Globulins Phase 2
26 Immunologic Factors Phase 2
27 Rho(D) Immune Globulin Phase 2
28 Antimalarials Phase 2
29 Anti-Bacterial Agents Phase 2
30 Antiparasitic Agents Phase 2
31 Antiprotozoal Agents Phase 2
32 Anti-Infective Agents Phase 2
33
Prednisolone acetate Approved, Vet_approved Phase 1 52-21-1
34
Prednisolone Approved, Vet_approved Phase 1 50-24-8 5755
35
Methylprednisolone Approved, Vet_approved Phase 1 83-43-2 6741
36
Prednisolone phosphate Approved, Vet_approved Phase 1 302-25-0
37
Methylprednisolone hemisuccinate Approved Phase 1 2921-57-5
38
Prednisolone hemisuccinate Experimental Phase 1 2920-86-7
39 Neuroprotective Agents Phase 1
40 Gastrointestinal Agents Phase 1
41 Methylprednisolone Acetate Phase 1
42 Antiemetics Phase 1
43 Hormone Antagonists Phase 1
44 glucocorticoids Phase 1
45 Protective Agents Phase 1
46 Hormones Phase 1
47 Antineoplastic Agents, Hormonal Phase 1
48
Warfarin Approved 81-81-2 54678486 6691
49
Diltiazem Approved, Investigational 42399-41-7 39186
50 Anticoagulants

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
2 Trial of Pulse Steroid Therapy in Kawasaki Disease (A Trial Conducted by the Pediatric Heart Network) Completed NCT00132080 Phase 3 Steroids
3 An Open Label, Non-comparative Phase II Trial to Evaluate the Effects of Atorvastatin on the Persistent Coronary Arterial Aneurysm in Children With Kawasaki Disease: Safety and Efficacy Unknown status NCT02114099 Phase 2 Atorvastatin
4 Prevention of Coronary Aneurysms in Kawasaki Syndrome Completed NCT00000520 Phase 2 immunoglobulins, intravenous;aspirin
5 Phase 2 Study to Assess the Efficacy and Safety of Doxycycline in Preventing Coronary Artery Aneurysm Formation and Progression Recruiting NCT01917721 Phase 2 Doxycycline;Placebo
6 Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease Recruiting NCT04509219 Phase 1 Methylprednisolone Injection
7 Coronary Artery Ectasia in Elective Coronary Angiography : Predictors, Outcomes and Management Unknown status NCT03896321 Antiplatelet Agents;Anticoagulants
8 Effects of Emotional Status on Coronary Flow in Patients Undergoing Coronary Angiography:Multicenter TIMI Frame Count Assessment Study (STRAIN-TIMI Study) Unknown status NCT02831153
9 Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method In Patients Undergoing Coronary Angiography Unknown status NCT02818127
10 Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries Unknown status NCT00548457
11 Coronary Artery Aneurysms: Incidence, Management and Long Term Prognosis Completed NCT02563626
12 Short Term Effect of Diltiazem on Myocardial Perfusion in Patients With Isolated Coronary Artery Ectasia- a Prospective Clinical Study Completed NCT02024919 intracoronary administration of diltiazem;intracoronary injection of 5 mL saline
13 Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES) Recruiting NCT00006150
14 A New Classification and Interventional Therapy for Coronary Artery Ectasia Recruiting NCT04265989

Search NIH Clinical Center for Coronary Aneurysm

Cochrane evidence based reviews: coronary aneurysm

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Genetic Tests for Coronary Aneurysm

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Anatomical Context for Coronary Aneurysm

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MalaCards organs/tissues related to Coronary Aneurysm:

40
Lymph Node, Endothelial, T Cells, Neutrophil
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Publications for Coronary Aneurysm

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Articles related to Coronary Aneurysm:

(show top 50) (show all 762)
# Title Authors PMID Year
1
Coronary Aneurysm Expansion with Thrombosis in a Young Man After Cardiopulmonary Resuscitation. 61
33288204 2021
2
Regression of Coronary Aneurysms With Intravenous Immunoglobulins and Steroids for COVID-19 Adult Multisystem Inflammatory Syndrome. 61
33782672 2021
3
Surgical treatment of coronary atherosclerotic heart disease with right coronary artery aneurysm: a case report. 61
32529911 2021
4
Giant right coronary aneurysm: a coronary CT angiography exhibited severe aneurysmatic dilation of the right coronary artery. 61
33085028 2021
5
Acute coronary syndrome in a young woman with a giant coronary aneurysm and mitral valve prolapse: a case report and literature review. 61
33752500 2021
6
[Interpretation of the JCS/JSCS 2020 guideline on diagnosis and management of cardiovascular sequelae in Kawasaki disease]. 61
33691912 2021
7
[Safety of warfarin therapy in children with coronary aneurysm due to Kawasaki disease]. 61
33548954 2021
8
A Giant Ruptured Noncoronary Sinus of Valsalva Aneurysm: A Case Report. 61
33635237 2021
9
Acquired coronary aneurysm after stent implantation at a bifurcation excluded with a Papyrus covered stent subsequently fenestrated. 61
33512648 2021
10
Culprit mistaken: development of a traumatic coronary aneurysm after mismatched culprit lesion-PCI for plaque rupture. 61
33155017 2021
11
Giant coronary aneurysm in a patient with autosomal dominant polycystic kidney disease. 61
32409846 2021
12
Irreversible coronary aneurysm presenting as acute coronary syndrome in a child with hypereosinophilic syndrome: a case report. 61
33487200 2021
13
Congenital Coronary Aneurysm: Unusual Presentation of Myocardial Ischemia in Children. 61
31023146 2021
14
Clinical aspects for differential diagnosis of Kawasaki disease shock syndrome: a case control study. 61
33413220 2021
15
Cardiac events in Patients in their forties with Kawasaki disease and regression of coronary artery aneurysms. 61
32912376 2020
16
A case report of a coronary artery fistula to coronary sinus with giant aneurysm: risk does not end with repair. 61
33447712 2020
17
Giant right coronary aneurysm as a cause of hiccups. 61
33454777 2020
18
Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult. 61
33181855 2020
19
Concomitant right coronary aneurysm and total occlusion of left anterior descending artery and left circumflex artery. 61
33128064 2020
20
[Coronary aneurysm, it exists !] 61
33155440 2020
21
Percutaneous Intervention of Coronary Aneurysm. 61
31523002 2020
22
Clinical characteristics of 10 children with a pediatric inflammatory multisystem syndrome associated with COVID-19 in Iran. 61
33167916 2020
23
Variation in the management of Kawasaki disease. 61
31196912 2020
24
Off pump surgical epicardial closure of left anterior descending to pulmonary artery fistula. 61
33032638 2020
25
Robotic minimally invasive direct coronary artery bypass for Kawasaki disease. 61
31555956 2020
26
Meningoencephalitis, coronary artery and keratitis as an onset of brucellosis: a case report. 61
32894070 2020
27
Insights from multimodality imaging in a case of giant true coronary aneurysm treated percutaneously with polytetrafluoroethylene covered stent. 61
32974458 2020
28
Anesthesia Management for a Patient with Coronary Artery Fistula and Huge Coronary Aneurysm Undergoing Off-Pump Surgery. 61
32178951 2020
29
Treatment approach to coronary aneurysms: percutaneous or surgical? 61
32517715 2020
30
Coronary Drug-Eluting Stent Infection Complicated by Coronary Artery Aneurysm and Purulent Pericarditis: Complete Resolution Without Surgery. 61
32407676 2020
31
Extensive coil embolization of a giant coronary artery aneurysm in an octogenarian: a case report. 61
32617506 2020
32
Cardiac tamponade due to ruptured coronary-pulmonary artery fistula aneurysm: a case report. 61
32617504 2020
33
Mycotic coronary aneurysm detected by 18F-FDG PET/CT: A case report. 61
32405985 2020
34
Successful interventional management of a giant atherosclerotic coronary aneurysm. 61
31740354 2020
35
An unknown mass on the cardiac surface with huge coronary aneurysm and fistula: A case report. 61
32092181 2020
36
Successful sparing approach between the ascending aorta and the main pulmonary artery to the giant coronary aneurysm of the left main coronary artery. 61
32332046 2020
37
A novel mouse model of coronary stenosis mimicking Kawasaki disease induced by Lactobacillus casei cell wall extract. 61
31932543 2020
38
Giant Right Coronary Artery Aneurysm Resembling Cardiac Tumor: A Case Report. 61
32364907 2020
39
Surgical Repair of Congenital Coronary Artery Fistula With Giant Aneurysm. 61
32364904 2020
40
A Spider in the Spider’s View: Behçet’s Disease-related Giant Coronary Aneurysm 61
31823592 2020
41
A stent fracture associated with giant coronary aneurysm. 61
31564023 2020
42
A giant aneurysm of the left anterior descending coronary artery in the setting of Behcet's disease. 61
32202588 2020
43
Mycotic Coronary Aneurysms. 61
30686642 2020
44
Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report. 61
32760733 2020
45
Increased Neutrophil Respiratory Burst Predicts the Risk of Coronary Artery Lesion in Kawasaki Disease. 61
32850525 2020
46
Giant Thrombotic Right Coronary Aneurysm in an Infant with Undiagnosed Incomplete Kawasaki Disease and Rapidly Progressive Cardiovascular Collapse. 61
32002478 2019
47
Tiny ruptured coronary aneurysm with coronary-pulmonary arterial fistula. 61
30128719 2019
48
Large Aneurysmal Rupture of Coronary-Pulmonary Artery Fistula After Buffalo Goring. 61
31848328 2019
49
Multimodality imaging in preparation for surgery of coronary to pulmonary arterial fistulas complicated with a huge coronary aneurysm. 61
31621955 2019
50
Exclusion of a coronary aneurysm with a polyurethane-covered stent. 61
31582669 2019
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Variations for Coronary Aneurysm

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Expression for Coronary Aneurysm

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Search GEO for disease gene expression data for Coronary Aneurysm.
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Pathways for Coronary Aneurysm

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Pathways related to Coronary Aneurysm according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
IL-17 Family Signaling Pathways 64
Show member pathways
 12.16 TNF MMP9 MMP3 IL6
2
Transcriptional misregulation in cancer 36
12.06 PTCRA MMP9 MMP3 IL6
3
Folate Metabolism 1
Show member pathways
 11.89 TNF PLG IL6 CRP ALB
4
Spinal Cord Injury 1
11.81 TNF MMP9 IL6 FCGR2A
5
Interleukin-4 and 13 signaling 65
11.76 TNF MMP9 MMP3 IL6
6
TNF signaling pathway 36
11.72 TNF MMP9 MMP3 IL6
7
Rheumatoid arthritis 36
11.69 TNF MMP3 IL6
8
Matrix Metalloproteinases 1
Show member pathways
 11.62 TNF PLG MMP9 MMP3
9
IgA-Producing B Cells in the Intestine 64
11.53 TNF IL6 FCGR2A
10
Lung fibrosis 1
11.49 TNF MMP9 IL6
11
Cell adhesion_ECM remodeling 23
11.46 PLG MMP9 MMP3
12
Cell adhesion_Cell-matrix glycoconjugates 23
11.22 PLG MMP9 MMP3
13
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.06 TNF MMP9 MMP3 IL6
14
Overview of nanoparticle effects 1
10.71 TNF IL6 CRP
15
amb2 Integrin signaling 1
10.7 TNF PLG MMP9 IL6 BLK
Sources

GO Terms for Coronary Aneurysm

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Cellular components related to Coronary Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 TNF PLG MMP9 MMP3 IL6 GPT

Biological processes related to Coronary Aneurysm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.73 TNF MMP9 MMP3 IL6
2 defense response to Gram-positive bacterium GO:0050830 9.63 TNF IL6 CRP
3 cellular protein metabolic process GO:0044267 9.62 PLG IL6 FSTL1 ALB
4 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.49 TNF IL6
5 response to amyloid-beta GO:1904645 9.48 MMP9 MMP3
6 extracellular matrix disassembly GO:0022617 9.43 PLG MMP9 MMP3
7 positive regulation of neuroinflammatory response GO:0150078 9.4 TNF IL6
8 cellular response to UV-A GO:0071492 9.37 MMP9 MMP3
9 vascular endothelial growth factor production GO:0010573 9.16 TNF IL6
10 regulation of neuroinflammatory response GO:0150077 9.13 MMP9 MMP3 IL6
11 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Coronary Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.8 PLG MMP9 MMP3
Sources

Sources for Coronary Aneurysm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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