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MCID: CRN006
MIFTS: 35

Coronary Aneurysm

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Coronary Aneurysm

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MalaCards integrated aliases for Coronary Aneurysm:

Name: Coronary Aneurysm 12 44 15 17 72
Arteriovenous Aneurysm of Coronary Vessels 12
Aneurysmal Lesion of Coronary Artery 12
Aneurysm of Coronary Vessels 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


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Disease Ontology 12 DOID:3362
ICD9CM 35 414.11
MeSH 44 D003323
SNOMED-CT 68 50570003
ICD10 33 I25.41
UMLS 72 C0010051
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Summaries for Coronary Aneurysm

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MalaCards based summary : Coronary Aneurysm, also known as arteriovenous aneurysm of coronary vessels, is related to kawasaki disease and intermediate coronary syndrome. An important gene associated with Coronary Aneurysm is LDB3 (LIM Domain Binding 3), and among its related pathways/superpathways are Microglia Activation During Neuroinflammation: Microglia Polarization and Cell adhesion_ECM remodeling. The drugs Aspirin and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include heart, lymph node and endothelial, and related phenotype is cardiovascular system.

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Related Diseases for Coronary Aneurysm

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Diseases related to Coronary Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 kawasaki disease 30.5 MMP9 CRP
2 intermediate coronary syndrome 30.4 PLG CRP
3 pericarditis 30.2 IL1RN CRP
4 exanthem 30.1 IL1RN CRP
5 acute myocardial infarction 29.9 PLG MMP9 CRP
6 lyme disease 29.5 MMP9 CRP
7 takayasu arteritis 29.5 MMP9 CRP
8 spondylitis 29.5 IL1RN CRP
9 vascular disease 29.1 PLG MMP9 CRP
10 coronary artery aneurysm 11.8
11 congenital coronary artery aneurysm 11.7
12 aneurysm 11.1
13 granulomatous orchitis 10.4 PTCRA CRP
14 myocardial infarction 10.4
15 vasculitis 10.4
16 coronary stenosis 10.3
17 ischemia 10.3
18 blue toe syndrome 10.2 PLG CRP
19 lymph node disease 10.2 CRP CA8
20 thrombosis 10.2
21 lymphatic system disease 10.2 CRP CA8
22 lemierre's syndrome 10.2 PLG CRP
23 endocardium disease 10.2 PLG CRP
24 systemic lupus erythematosus 10.2
25 lupus erythematosus 10.2
26 angina pectoris 10.2
27 inferior myocardial infarction 10.2
28 cryopyrin-associated periodic syndrome 10.2 IL1RN CRP
29 acute cholangitis 10.2 IL1RN CRP
30 aortic aneurysm 10.2
31 polyarteritis nodosa 10.2
32 hyper-igd syndrome 10.2 IL1RN CRP
33 schnitzler syndrome 10.2 IL1RN CRP
34 cartilage disease 10.1 IL1RN CRP
35 pericardium disease 10.1 IL1RN CRP
36 cardiac arrest 10.1
37 endocarditis 10.1
38 hemopericardium 10.1
39 cardiac tamponade 10.1
40 adult-onset still's disease 10.1 IL1RN CRP
41 aortic aneurysm, familial abdominal, 1 10.1
42 pericardial effusion 10.1
43 coronary thrombosis 10.1
44 brucellosis 10.0 IL1RN CRP
45 temporal arteritis 10.0 IL1RN CRP
46 neurofibromatosis, type iv, of riccardi 10.0
47 ventricular fibrillation, paroxysmal familial, 1 10.0
48 mitral valve insufficiency 10.0
49 coronary artery anomaly 10.0
50 heart septal defect 10.0

Graphical network of the top 20 diseases related to Coronary Aneurysm:



Diseases related to Coronary Aneurysm
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Symptoms & Phenotypes for Coronary Aneurysm

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MGI Mouse Phenotypes related to Coronary Aneurysm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 CLMP CRP IL1RN LDB3 MMP9 PLG
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Drugs & Therapeutics for Coronary Aneurysm

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Drugs for Coronary Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Cyclooxygenase Inhibitors Phase 4
5 Fibrinolytic Agents Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Antipyretics Phase 4
10
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
11 Antineoplastic Agents, Phytogenic Phase 2, Phase 3
12 Tubulin Modulators Phase 2, Phase 3
13 Albumin-Bound Paclitaxel Phase 2, Phase 3
14 Antimitotic Agents Phase 2, Phase 3
15
Atorvastatin Approved Phase 2 134523-00-5 60823
16
Infliximab Approved Phase 2 170277-31-3
17
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
18 Lipid Regulating Agents Phase 2
19 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
20 Hypolipidemic Agents Phase 2
21 Anticholesteremic Agents Phase 2
22 Antimetabolites Phase 2
23 Antibodies Phase 2
24 Immunologic Factors Phase 2
25 Immunoglobulins Phase 2
26 Immunoglobulins, Intravenous Phase 2
27 gamma-Globulins Phase 2
28 Rho(D) Immune Globulin Phase 2
29 Antirheumatic Agents Phase 2
30 Gastrointestinal Agents Phase 2
31 Anti-Infective Agents Phase 2
32 Antiparasitic Agents Phase 2
33 Anti-Bacterial Agents Phase 2
34 Dermatologic Agents Phase 2
35 Antimalarials Phase 2
36 Antiprotozoal Agents Phase 2
37
Diltiazem Approved, Investigational 42399-41-7 39186
38
Clopidogrel Approved 113665-84-2, 120202-66-6 60606
39
Warfarin Approved 81-81-2 6691 54678486
40
Calcium Approved, Nutraceutical 7440-70-2 271
41 Antihypertensive Agents
42 Hormones
43 Vasodilator Agents
44 calcium channel blockers
45 Calcium, Dietary
46 Neurotransmitter Agents
47 Purinergic P2Y Receptor Antagonists
48 Purinergic P2 Receptor Antagonists
49 Platelet Aggregation Inhibitors
50 Anticoagulants

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
2 Trial of Pulse Steroid Therapy in Kawasaki Disease (A Trial Conducted by the Pediatric Heart Network) Completed NCT00132080 Phase 3 Steroids
3 TAXUS V: De Novo Lesion: A Randomized, Double-blind Trial to Assess TAXUS Paclitaxel-Eluting Coronary Stents, SR Formulation, in the Treatment of De Novo Coronary Lesions Completed NCT00301522 Phase 2, Phase 3
4 An Open Label, Non-comparative Phase II Trial to Evaluate the Effects of Atorvastatin on the Persistent Coronary Arterial Aneurysm in Children With Kawasaki Disease: Safety and Efficacy Unknown status NCT02114099 Phase 2 Atorvastatin
5 Prevention of Coronary Aneurysms in Kawasaki Syndrome Completed NCT00000520 Phase 2 immunoglobulins, intravenous;aspirin
6 Phase 2 Study to Assess the Efficacy and Safety of Doxycycline in Preventing Coronary Artery Aneurysm Formation and Progression Recruiting NCT01917721 Phase 2 Doxycycline;Standard care
7 Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries Unknown status NCT00548457
8 Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method In Patients Undergoing Coronary Angiography Unknown status NCT02818127
9 Effects of Emotional Status on Coronary Flow in Patients Undergoing Coronary Angiography:Multicenter TIMI Frame Count Assessment Study (STRAIN-TIMI Study) Unknown status NCT02831153
10 Coronary Artery Aneurysms: Incidence, Management and Long Term Prognosis Completed NCT02563626
11 Short Term Effect of Diltiazem on Myocardial Perfusion in Patients With Isolated Coronary Artery Ectasia- a Prospective Clinical Study Completed NCT02024919 intracoronary administration of diltiazem;intracoronary injection of 5 mL saline
12 Coronary Artery Ectasia in Elective Coronary Angiography : Predictors, Outcomes and Management Not yet recruiting NCT03896321 Antiplatelet Agents;Anticoagulants

Search NIH Clinical Center for Coronary Aneurysm

Cochrane evidence based reviews: coronary aneurysm

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Genetic Tests for Coronary Aneurysm

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Anatomical Context for Coronary Aneurysm

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MalaCards organs/tissues related to Coronary Aneurysm:

41
Heart, Lymph Node, Endothelial, T Cells, Kidney, Neutrophil, Testes
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Publications for Coronary Aneurysm

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Articles related to Coronary Aneurysm:

(show top 50) (show all 710)
# Title Authors PMID Year
1
[Clinical effect and safety of clopidogrel combined with aspirin in antithrombotic therapy for children with Kawasaki disease complicated by small/medium-sized coronary artery aneurysms]. 38
31416506 2019
2
Case of Incomplete Kawasaki Disease with No Symptoms Except Fever Causing the Development of Coronary Aneurysm. 38
31204377 2019
3
Challenging surgery of giant right coronary aneurysm associated with coronary sinus fistula. 38
31269291 2019
4
Variation in the management of Kawasaki disease. 38
31196912 2019
5
Treatment Intensification in Patients With Kawasaki Disease and Coronary Aneurysm at Diagnosis. 38
31048414 2019
6
Comparison of Clinical Symptoms and Cardiac Lesions in Children with Typical and Atypical Kawasaki Disease. 38
31003567 2019
7
Congenital Coronary Aneurysm: Unusual Presentation of Myocardial Ischemia in Children. 38
31023146 2019
8
Fistulae ligation and left main artery ligation for a bilateral giant coronary arterial fistulae-related aneurysm. 38
30165512 2019
9
Coronary aneurysm with calcification in a young adult: An unusual cause of cardiac arrest. 38
30879699 2019
10
[Cardiac transplantation for treatment of Kawasaki disease complicated with giant coronary aneurysm]. 38
30818902 2019
11
Giant coronary aneurysms producing chest pain. 38
30850000 2019
12
Evaluating 3D-printed models of coronary anomalies: a survey among clinicians and researchers at a university hospital in the UK. 38
30852545 2019
13
A Framework for Comparing Vascular Hemodynamics at Different Points in Time. 38
30504967 2019
14
Internal thoracic artery patch repair of a saccular left main coronary artery aneurysm. 38
30808396 2019
15
[Application of selective coronary angiography in children with Kawasaki disease complicated with severe coronary artery lesion]. 38
30695884 2019
16
Lymph-node-first Kawasaki disease and giant coronary artery aneurysm. 38
30709892 2019
17
Hereditary Hemorrhagic Telangiectasia with SMAD4 Mutations Is Associated with Fatty Degeneration of the Left Ventricle, Coronary Artery Aneurysm, and Abdominal Aortic Aneurysm. 38
30210120 2019
18
Chain pain following cardiac surgery in a 35-year-old man. 38
30121632 2019
19
Partially Thrombosed Coronary Aneurysm in a Patient With Von Recklinghausen's Disease. 38
30660459 2019
20
Side by side: late coronary aneurysm as consequence of two parallel stents. 38
30610685 2019
21
Multimodal imaging of right coronary artery to left ventricle fistula complicated by large coronary aneurysm. 38
30882189 2019
22
Mycotic coronary aneurysm after percutaneous treatment of chronic total occlusion. 38
30451701 2019
23
Coronary aneurysm formation after paclitaxel-coated balloon angioplasty for in-stent restenosis of first-generation sirolimus-eluting stent implanted 9 years ago. 38
30637580 2019
24
Mycotic coronary aneurysms. 38
30418268 2019
25
Kawasaki disease shock syndrome complicated with macrophage activation syndrome in a 5-month old boy: A case report. 38
30681594 2019
26
Ligature of the Left Main Coronary Artery after Surgery in Kawasaki Disease: Case Report. 38
30810685 2019
27
Giant right coronary artery aneurysm secondary to Kawasaki disease in an infant. 38
30337796 2019
28
Thirty Years of Kawasaki Disease: A Single-Center Study at the University Hospital of Lausanne. 38
30761279 2019
29
Giant Right Coronary Artery Aneurysm Detected by Transthoracic Echocardiography. 38
31008037 2019
30
Mycotic Coronary Aneurysms. 38
30686642 2018
31
[Clinical features of children with Kawasaki disease aged over 5 years]. 38
30477622 2018
32
Multiple coronary and cerebral aneurysms in a patient with chronic thromboangiitis. 38
30416615 2018
33
Coronary artery aneurysm formation after drug-coated balloon treatment of de novo lesions: Two case reports. 38
30407362 2018
34
Giant right coronary artery aneurysm complicated by a fistula to the right atrium, mimicking a ruptured sinus of Valsalva aneurysm. 38
30279256 2018
35
Small right ventricular diverticulum mimicking coronary aneurysm. 38
29912444 2018
36
Tiny ruptured coronary aneurysm with coronary-pulmonary arterial fistula. 38
30128719 2018
37
Intraoperative identification and treatment of a giant right coronary artery aneurysm. 38
30070779 2018
38
Implantation of multiple polytetrafluoroethylene covered stent inside drug eluting stent to rescue purulent coronary artery ectasia with giant saccular aneurysm. 38
29404853 2018
39
Coronary aneurysms in the acute patient: Incidence, characterization and long-term management results. 38
29276176 2018
40
Percutaneous Closure of a Fistulous Giant Coronary Aneurysm. 38
29705160 2018
41
Case Image: Coronary aneurysm causing fistulization and compression of the left atrium. 38
29853704 2018
42
Acute myocardial infarction after blunt chest wall trauma with underlying coronary aneurysm: a case report. 38
29914384 2018
43
Left Main Coronary Artery Diverticulum: Case Report and Review of the Literature. 38
29904458 2018
44
Quality of life in children participating in a non-selective INR self-monitoring VKA-education programme. 38
29100908 2018
45
Self-apposing stent-assisted coil embolization for the treatment of coronary artery aneurysm. 38
28988417 2018
46
Giant coronary aneurysm culprit of an acute coronary syndrome. 38
29317116 2018
47
Transcatheter Aortic Valve Replacement Incidentalomas: A Multimodality Imaging Case of Giant Right Coronary Aneurysm. 38
29796318 2018
48
Stenotic false lumen as inflow of coronary aneurysm and full-metal jacket. 38
28688710 2018
49
Kawasaki disease: a comprehensive review. 38
30775588 2018
50
"Giant within a giant": a case of typical Kawasaki disease with a giant coronary aneurysm and a large coronary thrombus - a rare case report. 38
28835313 2018
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Variations for Coronary Aneurysm

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Expression for Coronary Aneurysm

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Search GEO for disease gene expression data for Coronary Aneurysm.
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Pathways for Coronary Aneurysm

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Pathways related to Coronary Aneurysm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.22 MMP9 IL1RN
2
Cell adhesion_ECM remodeling 22
11.11 PLG MMP9
3
amb2 Integrin signaling 1
10.94 PLG MMP9
4
Cell adhesion_Cell-matrix glycoconjugates 22
10.75 PLG MMP9
5
Syndecan-4-mediated signaling events 1
10.45 PLG MMP9
6
A-beta Pathways: Plaque Formation and APP Metabolism 65
9.98 PLG MMP9
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GO Terms for Coronary Aneurysm

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Biological processes related to Coronary Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 8.62 PLG MMP9

Molecular functions related to Coronary Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 PLG MMP9
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Sources for Coronary Aneurysm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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