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MCID: CRN006
MIFTS: 39

Coronary Aneurysm

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Coronary Aneurysm

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MalaCards integrated aliases for Coronary Aneurysm:

Name: Coronary Aneurysm 12 43 15 17 71
Arteriovenous Aneurysm of Coronary Vessels 12
Aneurysmal Lesion of Coronary Artery 12
Aneurysm of Coronary Vessels 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3362
ICD9CM 34 414.11
MeSH 43 D003323
SNOMED-CT 67 50570003
ICD10 32 I25.41
UMLS 71 C0010051
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Summaries for Coronary Aneurysm

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MalaCards based summary : Coronary Aneurysm, also known as arteriovenous aneurysm of coronary vessels, is related to coronary stenosis and vasculitis. An important gene associated with Coronary Aneurysm is CA8 (Carbonic Anhydrase 8), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Folate Metabolism. The drugs Aspirin and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and lymph node, and related phenotype is immune system.

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Related Diseases for Coronary Aneurysm

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Diseases related to Coronary Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 581)
# Related Disease Score Top Affiliating Genes
1 coronary stenosis 30.5 IL6 CRP ALB
2 vasculitis 30.5 TNF ITPKC IL6 CRP
3 polyarteritis nodosa 30.3 IL6 GPT CRP
4 microscopic polyangiitis 30.0 TNF FCGR2A
5 thrombocytosis 29.8 IL6 CRP ALB
6 acute myocardial infarction 29.7 TNF MMP9 IL6 CRP
7 pericardial effusion 29.6 IL6 IL1RN GPT CRP ALB
8 spondyloarthropathy 1 29.6 TNF MMP3 IL1RN CRP
9 aortitis 29.6 TNF IL6 IL1RN CRP
10 cellulitis 29.6 TNF IL6 CRP
11 infective endocarditis 29.6 TNF IL6 FCGR2A CRP
12 pericarditis 29.5 TNF IL6 IL1RN CRP ALB
13 spondylitis 29.4 TNF IL6 IL1RN CRP
14 endocarditis 29.4 TNF IL6 FCGR2A CRP ALB
15 toxic shock syndrome 29.4 TNF IL6 IL1RN CRP
16 aortic aneurysm 29.3 MMP9 MMP3 IL6 CRP
17 syphilis 29.3 TNF IL6 GPT CRP ALB
18 acquired immunodeficiency syndrome 29.3 TNF IL6 CRP ALB
19 familial hypercholesterolemia 29.3 TNF IL6 GPT CRP ALB
20 rheumatic fever 29.3 TNF IL6 FCGR2A ALB
21 conjunctivitis 29.3 TNF MMP9 IL6
22 aortic aneurysm, familial abdominal, 1 29.2 MMP9 MMP3 IL6 CRP
23 systemic autoimmune disease 29.1 MMP9 IL6 CRP
24 exanthem 29.1 TNF IL6 IL1RN GPT CRP ALB
25 hyperthyroidism 29.1 TNF IL6 GPT CRP ALB
26 end stage renal disease 29.0 TNF IL6 IL1RN CRP ALB
27 behcet syndrome 29.0 TNF IL6 IL1RN CRP ALB
28 lyme disease 29.0 TNF MMP9 IL6 CRP
29 myocardial infarction 28.4 TNF MMP9 MMP3 IL6 IL1RN GPT
30 vascular disease 28.4 TNF MMP9 MMP3 IL6 CRP ALB
31 kawasaki disease 28.2 TNF MMP9 MMP3 ITPKC IL6 GPT
32 hypertrophic cardiomyopathy 28.1 TNF MMP9 LDB3 IL6 ALB
33 autoimmune disease 27.9 TNF MMP9 IL6 IL1RN FCGR2A CRP
34 takayasu arteritis 27.8 TNF MMP9 MMP3 IL6 IL1RN FCGR2A
35 hypertension, essential 27.6 TNF MMP9 MMP3 IL6 GPT CRP
36 thrombocytopenia 27.6 TNF MMP9 IL6 IL1RN GPT FCGR2A
37 systemic lupus erythematosus 27.4 TNF MMP9 MMP3 IL6 IL1RN FCGR2A
38 lipoprotein quantitative trait locus 27.3 TNF MMP9 LDB3 ITPKC IL6 IL1RN
39 arthritis 27.3 TNF MMP9 MMP3 IL6 IL1RN FSTL1
40 rheumatoid arthritis 27.0 TNF MMP9 MMP3 IL6 IL1RN FSTL1
41 coronary artery aneurysm 11.8
42 congenital coronary artery aneurysm 11.7
43 aneurysm 11.1
44 chronic duodenal ileus 10.5 CRP ALB
45 drug reaction with eosinophilia and systemic symptoms 10.5 TNF CRP
46 dipetalonemiasis 10.5 GPT ALB
47 emphysematous cholecystitis 10.5 GPT CRP
48 anterior scleritis 10.5 IL1RN CRP
49 systemic onset juvenile idiopathic arthritis 10.4 TNF IL1RN
50 heterophyiasis 10.4 GPT ALB

Graphical network of the top 20 diseases related to Coronary Aneurysm:



Diseases related to Coronary Aneurysm
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Symptoms & Phenotypes for Coronary Aneurysm

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MGI Mouse Phenotypes related to Coronary Aneurysm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 ALB BLK CRP FCGR2A IL1RN IL6
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Drugs & Therapeutics for Coronary Aneurysm

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Drugs for Coronary Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2 Analgesics, Non-Narcotic Phase 4
3 Fibrinolytic Agents Phase 4
4 Purinergic P2Y Receptor Antagonists Phase 4
5 Cyclooxygenase Inhibitors Phase 4
6 Analgesics Phase 4
7 Antipyretics Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Antirheumatic Agents Phase 4
10 Neurotransmitter Agents Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
13 Albumin-Bound Paclitaxel Phase 2, Phase 3
14 Tubulin Modulators Phase 2, Phase 3
15 Antimitotic Agents Phase 2, Phase 3
16
Atorvastatin Approved Phase 2 134523-00-5 60823
17
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
18
Infliximab Approved Phase 2 170277-31-3
19 Hypolipidemic Agents Phase 2
20 Lipid Regulating Agents Phase 2
21 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
22 Anticholesteremic Agents Phase 2
23 Antimetabolites Phase 2
24 Platelet Aggregation Inhibitors Phase 2
25 Antibodies Phase 2
26 Rho(D) Immune Globulin Phase 2
27 Immunoglobulins, Intravenous Phase 2
28 Immunologic Factors Phase 2
29 gamma-Globulins Phase 2
30 Immunoglobulins Phase 2
31 Antiparasitic Agents Phase 2
32 Antiprotozoal Agents Phase 2
33 Anti-Bacterial Agents Phase 2
34 Anti-Infective Agents Phase 2
35 Antimalarials Phase 2
36
Diltiazem Approved, Investigational 42399-41-7 39186
37
Clopidogrel Approved 113665-84-2, 120202-66-6 60606
38
Warfarin Approved 81-81-2 6691 54678486
39 Antihypertensive Agents
40 Hormones
41 Vasodilator Agents
42 Calcium, Dietary
43 calcium channel blockers
44 Anticoagulants
45
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
2 Trial of Pulse Steroid Therapy in Kawasaki Disease (A Trial Conducted by the Pediatric Heart Network) Completed NCT00132080 Phase 3 Steroids
3 TAXUS V: De Novo Lesion: A Randomized, Double-blind Trial to Assess TAXUS Paclitaxel-Eluting Coronary Stents, SR Formulation, in the Treatment of De Novo Coronary Lesions Completed NCT00301522 Phase 2, Phase 3
4 An Open Label, Non-comparative Phase II Trial to Evaluate the Effects of Atorvastatin on the Persistent Coronary Arterial Aneurysm in Children With Kawasaki Disease: Safety and Efficacy Unknown status NCT02114099 Phase 2 Atorvastatin
5 Prevention of Coronary Aneurysms in Kawasaki Syndrome Completed NCT00000520 Phase 2 immunoglobulins, intravenous;aspirin
6 Phase 2 Study to Assess the Efficacy and Safety of Doxycycline in Preventing Coronary Artery Aneurysm Formation and Progression Recruiting NCT01917721 Phase 2 Doxycycline;Placebo
7 Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries Unknown status NCT00548457
8 Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method In Patients Undergoing Coronary Angiography Unknown status NCT02818127
9 Effects of Emotional Status on Coronary Flow in Patients Undergoing Coronary Angiography:Multicenter TIMI Frame Count Assessment Study (STRAIN-TIMI Study) Unknown status NCT02831153
10 Coronary Artery Aneurysms: Incidence, Management and Long Term Prognosis Completed NCT02563626
11 Short Term Effect of Diltiazem on Myocardial Perfusion in Patients With Isolated Coronary Artery Ectasia- a Prospective Clinical Study Completed NCT02024919 intracoronary administration of diltiazem;intracoronary injection of 5 mL saline
12 Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES) Recruiting NCT00006150
13 A New Classification and Interventional Therapy for Coronary Artery Ectasia Recruiting NCT04265989
14 Coronary Artery Ectasia in Elective Coronary Angiography : Predictors, Outcomes and Management Not yet recruiting NCT03896321 Antiplatelet Agents;Anticoagulants

Search NIH Clinical Center for Coronary Aneurysm

Cochrane evidence based reviews: coronary aneurysm

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Genetic Tests for Coronary Aneurysm

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Anatomical Context for Coronary Aneurysm

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MalaCards organs/tissues related to Coronary Aneurysm:

40
Heart, Endothelial, Lymph Node, Kidney, T Cells, Neutrophil, Testes
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Publications for Coronary Aneurysm

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Articles related to Coronary Aneurysm:

(show top 50) (show all 737)
# Title Authors PMID Year
1
Anesthesia Management for a Patient with Coronary Artery Fistula and Huge Coronary Aneurysm Undergoing Off-Pump Surgery. 61
32178951 2020
2
Treatment approach to coronary aneurysms: percutaneous or surgical? 61
32517715 2020
3
Surgical treatment of coronary atherosclerotic heart disease with right coronary artery aneurysm: a case report. 61
32529911 2020
4
Coronary Drug-Eluting Stent Infection Complicated by Coronary Artery Aneurysm and Purulent Pericarditis: Complete Resolution Without Surgery. 61
32407676 2020
5
Giant coronary aneurysm in a patient with autosomal dominant polycystic kidney disease. 61
32409846 2020
6
Mycotic coronary aneurysm detected by 18F-FDG PET/CT: A case report. 61
32405985 2020
7
An unknown mass on the cardiac surface with huge coronary aneurysm and fistula: A case report. 61
32092181 2020
8
A novel mouse model of coronary stenosis mimicking Kawasaki disease induced by Lactobacillus casei cell wall extract. 61
31932543 2020
9
Successful sparing approach between the ascending aorta and the main pulmonary artery to the giant coronary aneurysm of the left main coronary artery. 61
32332046 2020
10
Surgical Repair of Congenital Coronary Artery Fistula With Giant Aneurysm. 61
32364904 2020
11
Giant Right Coronary Artery Aneurysm Resembling Cardiac Tumor: A Case Report. 61
32364907 2020
12
A Spider in the Spider’s View: Behçet’s Disease-related Giant Coronary Aneurysm 61
31823592 2020
13
A stent fracture associated with giant coronary aneurysm. 61
31564023 2020
14
Mycotic Coronary Aneurysms. 61
30686642 2020
15
A giant aneurysm of the left anterior descending coronary artery in the setting of Behcet's disease. 61
32202588 2020
16
Giant Thrombotic Right Coronary Aneurysm in an Infant with Undiagnosed Incomplete Kawasaki Disease and Rapidly Progressive Cardiovascular Collapse. 61
32002478 2019
17
Tiny ruptured coronary aneurysm with coronary-pulmonary arterial fistula. 61
30128719 2019
18
Large Aneurysmal Rupture of Coronary-Pulmonary Artery Fistula After Buffalo Goring. 61
31848328 2019
19
Successful interventional management of a giant atherosclerotic coronary aneurysm. 61
31740354 2019
20
Multimodality imaging in preparation for surgery of coronary to pulmonary arterial fistulas complicated with a huge coronary aneurysm. 61
31621955 2019
21
Coronary aneurysm formation after paclitaxel-coated balloon angioplasty for in-stent restenosis of first-generation sirolimus-eluting stent implanted 9 years ago. 61
30637580 2019
22
Exclusion of a coronary aneurysm with a polyurethane-covered stent. 61
31582669 2019
23
Challenging surgery of giant right coronary aneurysm associated with coronary sinus fistula. 61
31269291 2019
24
Side by side: late coronary aneurysm as consequence of two parallel stents. 61
30610685 2019
25
Coronary aneurysm with calcification in a young adult: An unusual cause of cardiac arrest. 61
30879699 2019
26
Bilateral coronary artery-pulmonary artery fistulas with a giant coronary aneurysm. 61
31584438 2019
27
Robotic minimally invasive direct coronary artery bypass for Kawasaki disease. 61
31555956 2019
28
[Clinical effect and safety of clopidogrel combined with aspirin in antithrombotic therapy for children with Kawasaki disease complicated by small/medium-sized coronary artery aneurysms]. 61
31416506 2019
29
Percutaneous intervention of coronary aneurysm. 61
31523002 2019
30
Case of Incomplete Kawasaki Disease with No Symptoms Except Fever Causing the Development of Coronary Aneurysm. 61
31204377 2019
31
Treatment Intensification in Patients With Kawasaki Disease and Coronary Aneurysm at Diagnosis. 61
31048414 2019
32
Variation in the management of Kawasaki disease. 61
31196912 2019
33
Coronary Aneurysm: An Enigma Wrapped in a Mystery. 61
31614375 2019
34
Fistulae ligation and left main artery ligation for a bilateral giant coronary arterial fistulae-related aneurysm. 61
30165512 2019
35
Congenital Coronary Aneurysm: Unusual Presentation of Myocardial Ischemia in Children. 61
31023146 2019
36
Comparison of Clinical Symptoms and Cardiac Lesions in Children with Typical and Atypical Kawasaki Disease. 61
31003567 2019
37
[Cardiac transplantation for treatment of Kawasaki disease complicated with giant coronary aneurysm]. 61
30818902 2019
38
Giant coronary aneurysms producing chest pain. 61
30850000 2019
39
Evaluating 3D-printed models of coronary anomalies: a survey among clinicians and researchers at a university hospital in the UK. 61
30852545 2019
40
A Framework for Comparing Vascular Hemodynamics at Different Points in Time. 61
30504967 2019
41
Internal thoracic artery patch repair of a saccular left main coronary artery aneurysm. 61
30808396 2019
42
[Application of selective coronary angiography in children with Kawasaki disease complicated with severe coronary artery lesion]. 61
30695884 2019
43
Lymph-node-first Kawasaki disease and giant coronary artery aneurysm. 61
30709892 2019
44
Hereditary Hemorrhagic Telangiectasia with SMAD4 Mutations Is Associated with Fatty Degeneration of the Left Ventricle, Coronary Artery Aneurysm, and Abdominal Aortic Aneurysm. 61
30210120 2019
45
Chain pain following cardiac surgery in a 35-year-old man. 61
30121632 2019
46
Partially Thrombosed Coronary Aneurysm in a Patient With Von Recklinghausen's Disease. 61
30660459 2019
47
Combined bilateral giant coronary aneurysm and coronary fistula to coronary sinus. 61
31970743 2019
48
Multimodal imaging of right coronary artery to left ventricle fistula complicated by large coronary aneurysm. 61
30882189 2019
49
Mycotic coronary aneurysm after percutaneous treatment of chronic total occlusion. 61
30451701 2019
50
Mycotic coronary aneurysms. 61
30418268 2019
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Variations for Coronary Aneurysm

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Expression for Coronary Aneurysm

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Search GEO for disease gene expression data for Coronary Aneurysm.
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Pathways for Coronary Aneurysm

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Pathways related to Coronary Aneurysm according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
IL-17 Family Signaling Pathways 64
Show member pathways
 12.13 TNF MMP9 MMP3 IL6
2
Folate Metabolism 1
Show member pathways
 12.11 TNF IL6 CRP ALB
3
Transcriptional misregulation in cancer 36
12.02 PTCRA MMP9 MMP3 IL6
4
Spinal Cord Injury 1
11.75 TNF MMP9 IL6 FCGR2A
5
Matrix Metalloproteinases 1
Show member pathways
 11.7 TNF MMP9 MMP3
6
Interleukin-4 and 13 signaling 65
11.68 TNF MMP9 MMP3 IL6
7
Rheumatoid arthritis 36
11.65 TNF MMP3 IL6
8
TNF signaling pathway 36
11.61 TNF MMP9 MMP3 IL6
9
Lung fibrosis 1
11.43 TNF MMP9 IL6
10
Interleukin-10 signaling 65
11.27 TNF IL6 IL1RN
11
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.06 TNF MMP9 MMP3 IL6
12
Overview of nanoparticle effects 1
10.61 TNF IL6 CRP
13
amb2 Integrin signaling 1
10.61 TNF MMP9 IL6 BLK
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GO Terms for Coronary Aneurysm

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Cellular components related to Coronary Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 TNF MMP9 MMP3 IL6 IL1RN GPT

Biological processes related to Coronary Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.55 TNF MMP9 MMP3 IL6 IL1RN
2 response to glucocorticoid GO:0051384 9.5 TNF IL6 IL1RN
3 positive regulation of neuroinflammatory response GO:0150078 9.37 TNF IL6
4 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.26 IL6 IL1RN
5 regulation of neuroinflammatory response GO:0150077 9.13 MMP9 MMP3 IL6
6 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP
Sources

Sources for Coronary Aneurysm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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