MCID: CRN074
MIFTS: 47

Coronary Artery Aneurysm

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Coronary Artery Aneurysm

MalaCards integrated aliases for Coronary Artery Aneurysm:

Name: Coronary Artery Aneurysm 53
Coronary Artery Aneurysms 55
Coronary Aneurysm 73

Classifications:



External Ids:

ICD10 33 I25.4
UMLS 73 C0010051

Summaries for Coronary Artery Aneurysm

MalaCards based summary : Coronary Artery Aneurysm, also known as coronary artery aneurysms, is related to arteries, anomalies of and aortic aneurysm, familial abdominal, 1. An important gene associated with Coronary Artery Aneurysm is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. The drugs Aspirin and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include heart, lymph node and kidney, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 76 Coronary artery aneurysm is an abnormal dilatation of part of the coronary... more...

Related Diseases for Coronary Artery Aneurysm

Diseases in the Coronary Artery Aneurysm family:

Congenital Coronary Artery Aneurysm

Diseases related to Coronary Artery Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 30.3 ADIPOQ CCL2 LEP VCAM1
2 aortic aneurysm, familial abdominal, 1 30.1 CCL2 MMP1 MMP12 MMP13 MMP3
3 atherosclerosis susceptibility 30.0 ADIPOQ CCL2 VCAM1
4 arthritis 29.7 CCL2 MMP1 MMP13 MMP3
5 rheumatoid arthritis 29.6 CCL2 MMP1 MMP13 MMP3 VCAM1
6 congenital coronary artery aneurysm 12.4
7 kawasaki disease 11.9
8 myocardial infarction 10.7
9 coronary artery dissection, spontaneous 10.5
10 acute myocardial infarction 10.5
11 thrombosis 10.5
12 ischemia 10.4
13 cardiac tamponade 10.3
14 arteriovenous fistula 10.3
15 palladium allergic contact dermatitis 10.3 CCL17 CCL2
16 hypogonadism, male 10.2 KLK3 LEP
17 superior limbic keratoconjunctivitis 10.2 MMP1 MMP3
18 severe pre-eclampsia 10.2 ADIPOQ LEP VCAM1
19 bone chondrosarcoma 10.2 MMP1 MMP13
20 polyarteritis nodosa, childhood-onset 10.2
21 endocarditis 10.2
22 aortic aneurysm 10.2
23 polyarteritis nodosa 10.2
24 prostate rhabdomyosarcoma 10.2 KLK3 MMP1
25 localized scleroderma 10.1 MMP1 MMP13 VCAM1
26 systemic lupus erythematosus 10.1
27 mitral valve insufficiency 10.1
28 lupus erythematosus 10.1
29 mid-dermal elastolysis 10.1 MMP12 MMP7
30 carotid artery disease 10.1 CCL2 MMP1 MMP3
31 tendinopathy 10.1 MMP1 MMP3
32 periodontitis 10.1 CCL2 MMP1 MMP3
33 light chain deposition disease 10.1 MMP1 MMP12 MMP7
34 spastic entropion 10.1 MMP1 MMP3 MMP7
35 adult astrocytic tumour 10.1 MMP1 MMP3 MMP7
36 cardiac conduction defect 10.1
37 angina pectoris 10.1
38 coronary artery anomaly 10.1
39 varicose veins 10.1 MMP1 MMP3 MMP7
40 obesity-hypoventilation syndrome 10.0 ADIPOQ LEP RETN
41 idiopathic recurrent pericarditis 10.0 ADIPOQ LEP RETN
42 internal hemorrhoid 10.0 MMP1 MMP7
43 chondrosarcoma 10.0 MMP1 MMP13 MMP3
44 fatty liver disease, nonalcoholic 1 10.0 ADIPOQ LEP RETN
45 acquired generalized lipodystrophy 10.0 ADIPOQ LEP RETN
46 3-hydroxyacyl-coa dehydrogenase deficiency 10.0 ADIPOQ LEP RETN
47 synovitis 10.0 MMP1 MMP13 MMP3 VCAM1
48 bone inflammation disease 10.0 CCL2 MMP1 MMP13 MMP3
49 lipid metabolism disorder 10.0 ADIPOQ LEP RETN
50 glucose metabolism disease 10.0 ADIPOQ LEP RETN

Comorbidity relations with Coronary Artery Aneurysm via Phenotypic Disease Network (PDN):


Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Coronary Artery Aneurysm:



Diseases related to Coronary Artery Aneurysm

Symptoms & Phenotypes for Coronary Artery Aneurysm

MGI Mouse Phenotypes related to Coronary Artery Aneurysm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ABHD16A ADIPOQ BAG6 ITPR3 LEP MMP1
2 immune system MP:0005387 9.36 ABHD16A ADIPOQ CCL17 CCL2 LEP MMP1

Drugs & Therapeutics for Coronary Artery Aneurysm

Drugs for Coronary Artery Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
2
Ticlopidine Approved Phase 4 55142-85-3 5472
3
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
4 Anti-Inflammatory Agents Phase 4
5 Platelet Aggregation Inhibitors Phase 4
6 Neurotransmitter Agents Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Analgesics Phase 4
9 Cytochrome P-450 CYP2C19 Inhibitors Phase 4
10 Fibrinolytic Agents Phase 4
11 Purinergic P2 Receptor Antagonists Phase 4
12 Analgesics, Non-Narcotic Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Purinergic P2Y Receptor Antagonists Phase 4
15 Antirheumatic Agents Phase 4,Phase 2
16 Peripheral Nervous System Agents Phase 4
17 Antipyretics Phase 4
18 Cyclooxygenase Inhibitors Phase 4
19
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3 33069-62-4 36314
20 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3
21 Antimitotic Agents Phase 2, Phase 3,Phase 3
22 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3
23
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
24
Infliximab Approved Phase 2 170277-31-3
25 Atorvastatin Calcium Phase 2 134523-03-8
26 Hypolipidemic Agents Phase 2
27 Calcium, Dietary Phase 2,Not Applicable
28 Lipid Regulating Agents Phase 2
29 Anticholesteremic Agents Phase 2
30 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
31 Antimetabolites Phase 2
32 Immunoglobulins, Intravenous Phase 2
33 Antibodies Phase 2
34 gamma-Globulins Phase 2
35 Immunoglobulins Phase 2
36 Immunologic Factors Phase 2
37 Rho(D) Immune Globulin Phase 2
38 Antiprotozoal Agents Phase 2
39 Anti-Infective Agents Phase 2
40 Antiparasitic Agents Phase 2
41 Dermatologic Agents Phase 2
42 Anti-Bacterial Agents Phase 2
43 Antimalarials Phase 2
44 Gastrointestinal Agents Phase 2
45 Interleukin 1 Receptor Antagonist Protein Phase 2
46
Diltiazem Approved, Investigational Not Applicable 42399-41-7 39186
47
Adenosine Approved, Investigational Not Applicable 58-61-7 60961
48
Dobutamine Approved Not Applicable 34368-04-2 36811
49 Vasodilator Agents Not Applicable
50 Antihypertensive Agents Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial to Assess the Efficacy of Combination Formula of Aspirin Plus Clopidogrel in Patients With Coronary Stent Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
2 Trial of Pulse Steroid Therapy in Kawasaki Disease--Pediatric Heart Network Completed NCT00132080 Phase 3 Steroids
3 Randomized Trial Evaluating Slow-Release Formulation TAXUS Paclitaxel-Eluting Coronary Stents to Treat De Novo Coronary Lesions Completed NCT00301522 Phase 2, Phase 3
4 Randomized Trial Evaluating Slow-Release Formulation TAXUS Paclitaxel-Eluting Coronary Stent in the Treatment of In-Stent Restenosis Completed NCT00287573 Phase 2, Phase 3
5 Trial of Atorvastatin on the Persistent Coronary Aneurysm in Children With Kawasaki Disease Unknown status NCT02114099 Phase 2 Atorvastatin
6 Prevention of Coronary Aneurysms in Kawasaki Syndrome Completed NCT00000520 Phase 2 immunoglobulins, intravenous;aspirin
7 Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease Recruiting NCT01917721 Phase 2 Doxycycline;Standard care
8 Anakinra and Kawasaki Disease Recruiting NCT02390596 Phase 2 Anakinra
9 Study of Efficacy and Safety of Canakinumab in Pediatric Patients With Kawasaki Disease Withdrawn NCT02980263 Phase 2 Canakinumab
10 Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries Unknown status NCT00548457
11 Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method (TCCT-TIMI) Unknown status NCT02818127 Not Applicable
12 Etiology Study of Kawasaki Disease Unknown status NCT00154596
13 Evaluation of Emotional Status and Coronary Flow Characteristics by TIMI Frame Count Method Unknown status NCT02831153 Not Applicable
14 Coronary Artery Aneurysm Registry Completed NCT02563626
15 Effect of Diltiazem on Coronary Artery Ectasia Completed NCT02024919 Not Applicable intracoronary administration of diltiazem;intracoronary injection of 5 mL saline
16 Prevalence and Early Markers of Atherosclerosis in Adults With a History of Kawasaki Disease Completed NCT01440075 Not Applicable

Search NIH Clinical Center for Coronary Artery Aneurysm

Genetic Tests for Coronary Artery Aneurysm

Anatomical Context for Coronary Artery Aneurysm

MalaCards organs/tissues related to Coronary Artery Aneurysm:

41
Heart, Lymph Node, Kidney, Prostate, Lung, Liver, Bone

Publications for Coronary Artery Aneurysm

Articles related to Coronary Artery Aneurysm:

(show top 50) (show all 923)
# Title Authors Year
1
Giant right coronary artery aneurysm secondary to Kawasaki disease in an infant. ( 30337796 )
2019
2
Distal Left Main Coronary Artery Aneurysm Resection during 5-Vessel Coronary Artery Bypass Grafting. ( 29844743 )
2018
3
Giant right coronary artery aneurysm mimicking pericardial tamponade. ( 29675968 )
2018
4
Progression of a coronary artery aneurysm with symptomatic compression of cardiac structures. ( 29905782 )
2018
5
Giant coronary artery aneurysm at autopsy. ( 29559482 )
2018
6
Sudden Death as a Sequel of Ruptured Giant Coronary Artery Aneurysm in Kawasaki Disease. ( 29939842 )
2018
7
Self-apposing stent-assisted coil embolization for the treatment of coronary artery aneurysm. ( 28988417 )
2018
8
Thrombotic Occlusion and Revascularization of a Left Main Coronary Artery Aneurysm Years After Surgical Closure of LeftA Coronary-to-Right Ventricle Fistula. ( 29361450 )
2018
9
Medically managed coronary artery aneurysm without concomitant stenosis. ( 29764828 )
2018
10
Predictors of intravenous immunoglobulin resistance and coronary artery aneurysm in patients with Kawasaki disease. ( 29768976 )
2018
11
Left Main Coronary Artery Aneurysm. ( 29874527 )
2018
12
Rare Case of Giant Non-Thrombosed Coronary Artery Aneurysm at the Left Anterior Descending Coronary Artery. ( 29459496 )
2018
13
Giant coronary artery aneurysm with a coronary artery fistula to the pulmonary artery. ( 29490424 )
2018
14
Surgery of giant right coronary artery aneurysm complicated with coronary artery fistula to left ventricle. ( 29415369 )
2018
15
Left main coronary artery aneurysm presenting with unstable angina. ( 29971824 )
2018
16
Coronary artery aneurysm regression after Kawasaki disease and associated risk factors: a 3-year follow-up study in East China. ( 29330741 )
2018
17
Subaortic ventricular pouch in repaired tetralogy of Fallot mimicking right coronary artery aneurysm. ( 29501460 )
2018
18
Histopathology of Giant Coronary Artery Aneurysm Associated with Coronary Artery Fistula. ( 29479011 )
2018
19
Ruptured Giant Coronary Artery Aneurysm With Coronary Artery to Pulmonary Artery Fistula Presenting as Cardiac Tamponade Diagnosed by Intraoperative Transesophageal Echocardiography: A Case Report. ( 29634538 )
2018
20
The "Nodes" in Polyarteritis Nodosa-Coronary Artery Aneurysms. ( 29846272 )
2018
21
Chest X-Ray Revealed a Slowly Progressive Giant Right Coronary Artery Aneurysm in an Asymptomatic Patient. ( 29544225 )
2018
22
Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm. ( 29455693 )
2018
23
A right coronary artery aneurysm presenting as a mass in echocardiography. ( 29616418 )
2018
24
Acute Myocardial Infarction Due to Prolapse of Covered Stent Into Coronary Artery Aneurysm. ( 30172795 )
2018
25
Hereditary Hemorrhagic Telangiectasia with SMAD4 Mutations is Associated with Fatty Degeneration of the Left Ventricle, Coronary Artery Aneurysm, and Abdominal Aortic Aneurysm. ( 30210120 )
2018
26
A giant coronary artery aneurysm associated with multiple peripheral arterial aneurysms and an abdominal aortic aneurysm. ( 30124861 )
2018
27
Giant right coronary artery aneurysm presenting as cardiac tamponade. ( 29800339 )
2018
28
Scarce case of giant coronary artery aneurysm combined with huge pseudoaneurysm causing cardiac tamponade. ( 30226015 )
2018
29
Coronary Artery Aneurysm Formation: Kawasaki Disease versus Atherosclerosis. ( 29320319 )
2018
30
Case Image: Percutaneous approach to giant coronary artery aneurysm: successful implantation of covered stent graft. ( 29339680 )
2018
31
Coronary Artery Aneurysm Caused by a Stent Fracture. ( 29375112 )
2018
32
Large left main coronary artery aneurysm with fistula to the right atrium. ( 30069404 )
2018
33
Intraoperative identification and treatment of a giant right coronary artery aneurysm. ( 30070779 )
2018
34
Successful Surgical Treatment of Giant Coronary Artery Aneurysm and Concomitant Coronary Artery Fistula to the Pulmonary Artery. ( 30084772 )
2018
35
An Arrhythmogenic Large Coronary Artery Aneurysm. ( 30101919 )
2018
36
Percutaneous treatment of a saccular coronary artery aneurysm using multimodal imaging and rapid prototyping. ( 30113621 )
2018
37
Effective infliximab therapy for the early regression of coronary artery aneurysm in Kawasaki disease. ( 30144998 )
2018
38
Coronary Artery Aneurysm Formation after Drug-Coated Balloon Treatment. ( 30203807 )
2018
39
Surgical repair of a left main coronary artery aneurysm. ( 30221393 )
2018
40
Obtuse marginal coronary artery aneurysm on CT coronary angiogram. ( 30228847 )
2018
41
A PEAR1 polymorphism (rs12041331) is associated with risk of coronary artery aneurysm in Kawasaki disease. ( 30256383 )
2018
42
Identification of the TIFAB Gene as a Susceptibility Locus for Coronary Artery Aneurysm in Patients with Kawasaki Disease. ( 30267110 )
2018
43
Surgical repair of bilateral coronary artery fistulae and a left main coronary artery aneurysm following a failed percutaneous embolization. ( 30270450 )
2018
44
Giant right coronary artery aneurysm complicated by a fistula to the right atrium, mimicking a ruptured sinus of Valsalva aneurysm. ( 30279256 )
2018
45
Giant circumflex coronary artery aneurysm presenting as an intra-pericardial mass. ( 30306619 )
2018
46
Kawasaki disease: an essential comparison of coronary artery aneurysm criteria. ( 30337184 )
2018
47
Giant left main coronary artery aneurysm: How to deal with it? ( 30366752 )
2018
48
Coronary artery aneurysm formation after drug-coated balloon treatment of de novo lesions: Two case reports. ( 30407362 )
2018
49
Case Image: Endovascular coil treatment of a right coronary artery aneurysm related to atherosclerosis. ( 30516535 )
2018
50
Left main coronary artery aneurysm with a fistula draining into the right atrium. ( 30525234 )
2018

Variations for Coronary Artery Aneurysm

Expression for Coronary Artery Aneurysm

Search GEO for disease gene expression data for Coronary Artery Aneurysm.

Pathways for Coronary Artery Aneurysm

Pathways related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 CCL17 CCL2 ITPR3 MMP1 MMP12 MMP13
2
Show member pathways
12.54 MMP1 MMP12 MMP13 MMP3 MMP7 VCAM1
3
Show member pathways
12.13 CCL2 MMP1 MMP13 MMP3
4
Show member pathways
12.05 CCL17 CCL2 MMP1 MMP13 MMP3
5
Show member pathways
11.93 ITPR3 PLCB1 PLCB4
6 11.92 ITPR3 PLCB1 PLCB4
7 11.91 CCL2 LEP MMP12
8 11.89 KLK3 MMP13 MMP3 VCAM1
9 11.87 ITPR3 PLCB1 PLCB4
10 11.85 ITPR3 PLCB1 PLCB4
11 11.84 CCL2 MMP3 VCAM1
12 11.84 CCL2 MMP1 MMP3 VCAM1
13 11.8 ITPR3 PLCB1 PLCB4
14 11.79 ITPR3 PLCB1 PLCB4
15 11.78 ITPR3 MMP13 PLCB1 PLCB4
16 11.76 ITPR3 PLCB1 PLCB4
17 11.73 CCL2 MMP1 MMP3
18 11.73 CCL2 PLCB1 PLCB4 VCAM1
19 11.71 ITPR3 PLCB1 PLCB4
20
Show member pathways
11.65 MMP1 MMP12 MMP13 MMP3 MMP7
21 11.62 CCL2 MMP13 MMP3 MMP7
22 11.61 CCL17 CCL2 MMP3
23 11.56 ITPR3 PLCB1 PLCB4
24
Show member pathways
11.53 MMP1 MMP3 VCAM1
25 11.5 ITPR3 PLCB1 PLCB4
26 11.47 ITPR3 PLCB1 PLCB4
27
Show member pathways
11.47 CCL17 CCL2 ITPR3 MMP1 MMP12 MMP13
28 11.3 MMP13 PLCB1 PLCB4
29 11.24 PLCB1 PLCB4 VCAM1
30 11.23 ITPR3 PLCB1 PLCB4
31 11.22 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
32 11.18 ITPR3 PLCB1 PLCB4
33 10.99 KLK3 MMP1
34 10.93 CCL2 MMP1
35 10.86 MMP1 MMP7
36 10.82 CCL2 VCAM1

GO Terms for Coronary Artery Aneurysm

Cellular components related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ADIPOQ BAG6 CCL17 CCL2 KLK3 LEP
2 extracellular matrix GO:0031012 9.55 MMP1 MMP12 MMP13 MMP3 MMP7
3 extracellular space GO:0005615 9.36 ADIPOQ CCL17 CCL2 KLK3 LEP MMP12

Biological processes related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.8 ADIPOQ CCL17 CCL2 LEP RETN
2 proteolysis GO:0006508 9.8 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
3 cytokine-mediated signaling pathway GO:0019221 9.76 CCL2 MMP1 MMP3 VCAM1
4 response to ethanol GO:0045471 9.69 ADIPOQ LEP VCAM1
5 response to nutrient GO:0007584 9.61 ADIPOQ LEP VCAM1
6 response to hypoxia GO:0001666 9.55 ADIPOQ LEP MMP12 MMP3 VCAM1
7 response to nutrient levels GO:0031667 9.54 ADIPOQ LEP MMP7
8 leukocyte tethering or rolling GO:0050901 9.49 LEP VCAM1
9 positive regulation of protein oligomerization GO:0032461 9.48 MMP1 MMP3
10 extracellular matrix disassembly GO:0022617 9.35 MMP1 MMP12 MMP13 MMP3 MMP7
11 positive regulation of developmental growth GO:0048639 9.26 LEP PLCB1
12 collagen catabolic process GO:0030574 9.02 MMP1 MMP12 MMP13 MMP3 MMP7

Molecular functions related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.97 ABHD16A KLK3 MMP1 MMP12 MMP13 MMP3
2 peptidase activity GO:0008233 9.85 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
3 signaling receptor binding GO:0005102 9.8 ADIPOQ BAG6 CCL17 CCL2 LEP
4 hormone activity GO:0005179 9.63 ADIPOQ LEP RETN
5 endopeptidase activity GO:0004175 9.56 KLK3 MMP1 MMP12 MMP3
6 metallopeptidase activity GO:0008237 9.55 MMP1 MMP12 MMP13 MMP3 MMP7
7 phospholipase C activity GO:0004629 9.43 PLCB1 PLCB4
8 serine-type endopeptidase activity GO:0004252 9.43 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
9 metalloendopeptidase activity GO:0004222 9.02 MMP1 MMP12 MMP13 MMP3 MMP7

Sources for Coronary Artery Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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