MCID: CRN074
MIFTS: 41

Coronary Artery Aneurysm

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Coronary Artery Aneurysm

MalaCards integrated aliases for Coronary Artery Aneurysm:

Name: Coronary Artery Aneurysm 20 32
Coronary Artery Aneurysms 54
Coronary Aneurysm 70

Classifications:



External Ids:

ICD10 32 I25.4
UMLS 70 C0010051

Summaries for Coronary Artery Aneurysm

MalaCards based summary : Coronary Artery Aneurysm, also known as coronary artery aneurysms, is related to aneurysm and myocardial infarction. An important gene associated with Coronary Artery Aneurysm is MMP1 (Matrix Metallopeptidase 1), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, lymph node and endothelial.

Wikipedia : 73 Coronary artery aneurysm is an abnormal dilatation of part of the coronary... more...

Related Diseases for Coronary Artery Aneurysm

Diseases in the Coronary Artery Aneurysm family:

Congenital Coronary Artery Aneurysm

Diseases related to Coronary Artery Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 aneurysm 32.0 MMP13 MMP12
2 myocardial infarction 30.0 MMP7 MMP3 MMP13 MMP1
3 aortic aneurysm, familial thoracic 1 29.8 MMP12 MMP1
4 marfan syndrome 29.7 MMP3 MMP12 MMP1
5 aortic aneurysm, familial abdominal, 1 29.6 MMP3 MMP13 MMP12 MMP1
6 rheumatoid arthritis 29.1 MMP3 MMP13 MMP12 MMP1
7 congenital coronary artery aneurysm 11.3
8 kawasaki disease 11.0
9 coronary aneurysm 10.9
10 vasculitis 10.7
11 cardiac tamponade 10.6
12 acute myocardial infarction 10.6
13 coronary stenosis 10.6
14 thrombosis 10.5
15 aortic aneurysm 10.5
16 inferior myocardial infarction 10.5
17 intermediate coronary syndrome 10.5
18 endocarditis 10.5
19 angina pectoris 10.4
20 hemopericardium 10.4
21 mitral valve insufficiency 10.4
22 pericardial effusion 10.4
23 infective endocarditis 10.3
24 ischemia 10.3
25 coronary artery dissection, spontaneous 10.3
26 aortic dissection 10.3
27 heart septal defect 10.3
28 congestive heart failure 10.3
29 syncope 10.3
30 atherosclerosis susceptibility 10.2
31 exanthem 10.2
32 pericarditis 10.2
33 atrial heart septal defect 10.2
34 aortic valve insufficiency 10.2
35 cardiogenic shock 10.2
36 conjunctivitis 10.2
37 systemic lupus erythematosus 10.2
38 tetralogy of fallot 10.2
39 takayasu arteritis 10.2
40 anterolateral myocardial infarction 10.2
41 neurofibromatosis 10.2
42 lupus erythematosus 10.2
43 polyarteritis nodosa 10.2
44 aneurysm of sinus of valsalva 10.2
45 noonan syndrome 1 10.1
46 granulomatosis with polyangiitis 10.1
47 vascular disease 10.1
48 pseudo-turner syndrome 10.1
49 arteries, anomalies of 10.1
50 cardiac conduction defect 10.1

Comorbidity relations with Coronary Artery Aneurysm via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Mitral Valve Disease

Graphical network of the top 20 diseases related to Coronary Artery Aneurysm:



Diseases related to Coronary Artery Aneurysm

Symptoms & Phenotypes for Coronary Artery Aneurysm

Drugs & Therapeutics for Coronary Artery Aneurysm

Drugs for Coronary Artery Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
3 Analgesics, Non-Narcotic Phase 4
4 Fibrinolytic Agents Phase 4
5 Cyclooxygenase Inhibitors Phase 4
6 Antirheumatic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Analgesics Phase 4
9 Antipyretics Phase 4
10 Platelet Aggregation Inhibitors Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Neurotransmitter Agents Phase 4
13 Purinergic P2Y Receptor Antagonists Phase 4
14
Atorvastatin Approved Phase 2 134523-00-5 60823
15
Infliximab Approved Phase 2 170277-31-3
16
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
17 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
18 Antimetabolites Phase 2
19 Lipid Regulating Agents Phase 2
20 Anticholesteremic Agents Phase 2
21 Hypolipidemic Agents Phase 2
22 Immunoglobulins Phase 2
23 Antibodies Phase 2
24 Immunoglobulins, Intravenous Phase 2
25 gamma-Globulins Phase 2
26 Immunologic Factors Phase 2
27 Rho(D) Immune Globulin Phase 2
28 Antimalarials Phase 2
29 Anti-Bacterial Agents Phase 2
30 Antiparasitic Agents Phase 2
31 Antiprotozoal Agents Phase 2
32 Anti-Infective Agents Phase 2
33
Prednisolone acetate Approved, Vet_approved Phase 1 52-21-1
34
Prednisolone Approved, Vet_approved Phase 1 50-24-8 5755
35
Methylprednisolone Approved, Vet_approved Phase 1 83-43-2 6741
36
Prednisolone phosphate Approved, Vet_approved Phase 1 302-25-0
37
Methylprednisolone hemisuccinate Approved Phase 1 2921-57-5
38
Prednisolone hemisuccinate Experimental Phase 1 2920-86-7
39 Neuroprotective Agents Phase 1
40 Gastrointestinal Agents Phase 1
41 Methylprednisolone Acetate Phase 1
42 Antiemetics Phase 1
43 Hormone Antagonists Phase 1
44 glucocorticoids Phase 1
45 Protective Agents Phase 1
46 Hormones Phase 1
47 Antineoplastic Agents, Hormonal Phase 1
48
Warfarin Approved 81-81-2 54678486 6691
49
Diltiazem Approved, Investigational 42399-41-7 39186
50 Anticoagulants

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
2 Trial of Pulse Steroid Therapy in Kawasaki Disease (A Trial Conducted by the Pediatric Heart Network) Completed NCT00132080 Phase 3 Steroids
3 An Open Label, Non-comparative Phase II Trial to Evaluate the Effects of Atorvastatin on the Persistent Coronary Arterial Aneurysm in Children With Kawasaki Disease: Safety and Efficacy Unknown status NCT02114099 Phase 2 Atorvastatin
4 Prevention of Coronary Aneurysms in Kawasaki Syndrome Completed NCT00000520 Phase 2 immunoglobulins, intravenous;aspirin
5 Phase 2 Study to Assess the Efficacy and Safety of Doxycycline in Preventing Coronary Artery Aneurysm Formation and Progression Recruiting NCT01917721 Phase 2 Doxycycline;Placebo
6 Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease Recruiting NCT04509219 Phase 1 Methylprednisolone Injection
7 Coronary Artery Ectasia in Elective Coronary Angiography : Predictors, Outcomes and Management Unknown status NCT03896321 Antiplatelet Agents;Anticoagulants
8 Effects of Emotional Status on Coronary Flow in Patients Undergoing Coronary Angiography:Multicenter TIMI Frame Count Assessment Study (STRAIN-TIMI Study) Unknown status NCT02831153
9 Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method In Patients Undergoing Coronary Angiography Unknown status NCT02818127
10 Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries Unknown status NCT00548457
11 Coronary Artery Aneurysms: Incidence, Management and Long Term Prognosis Completed NCT02563626
12 Short Term Effect of Diltiazem on Myocardial Perfusion in Patients With Isolated Coronary Artery Ectasia- a Prospective Clinical Study Completed NCT02024919 intracoronary administration of diltiazem;intracoronary injection of 5 mL saline
13 A New Classification and Interventional Therapy for Coronary Artery Ectasia Recruiting NCT04265989
14 Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES) Recruiting NCT00006150

Search NIH Clinical Center for Coronary Artery Aneurysm

Genetic Tests for Coronary Artery Aneurysm

Anatomical Context for Coronary Artery Aneurysm

MalaCards organs/tissues related to Coronary Artery Aneurysm:

40
Heart, Lymph Node, Endothelial, Whole Blood, T Cells, Neutrophil, Bronchial Epithelium

Publications for Coronary Artery Aneurysm

Articles related to Coronary Artery Aneurysm:

(show top 50) (show all 2101)
# Title Authors PMID Year
1
Characteristics and trends in diagnosis of Kawasaki disease outside the usual age range. 61
32845440 2021
2
Incidence and short-term outcomes of Kawasaki disease. 61
33785879 2021
3
Cyclophosphamide use in treatment of refractory Kawasaki disease with coronary artery aneurysms. 61
33731148 2021
4
Comparison Between Currently Recommended Long-Term Medical Management of Coronary Artery Aneurysms After Kawasaki Disease and Actual Reported Management in the Last Two Decades. 61
33439285 2021
5
IgA Levels Are Associated with Coronary Artery Lesions in Kawasaki Disease. 61
33655727 2021
6
Epidemiology and Risk Factors for Giant Coronary Artery Aneurysms Identified After Acute Kawasaki Disease. 61
33682062 2021
7
Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease. 61
33772158 2021
8
Primary adjunctive corticosteroid therapy is associated with improved outcomes for patients with Kawasaki disease with coronary artery aneurysms at diagnosis. 61
32943389 2021
9
Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. 61
33625505 2021
10
Acute coronary syndrome in a young woman with a giant coronary aneurysm and mitral valve prolapse: a case report and literature review. 61
33752500 2021
11
Multiple coronary aneurysms and acute myocardial infarction in a female patient with rhupus: case report and literature review. 61
32734406 2021
12
Coronary artery aneurysms in patients with Marfan syndrome: frequent, progressive and relevant: Coronary artery aneurysms in Marfan syndrome. 61
33711475 2021
13
A Large Mediastinal Mass in a Young Woman: A Case of Giant Coronary Artery Aneurysm. 61
33741325 2021
14
Time Course of Coronary Artery Aneurysms in Kawasaki Disease. 61
33301786 2021
15
A Pediatric Case Report of Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis With Pericardial Effusion and Multiple Coronary Artery Aneurysms. 61
31688637 2021
16
Surgical treatment of coronary atherosclerotic heart disease with right coronary artery aneurysm: a case report. 61
32529911 2021
17
Coronary artery aneurysm presenting as acute coronary syndrome: two case reports and a review of the literature. 61
33743116 2021
18
Giant unruptured circumflex coronary artery aneurysms presenting as acute coronary syndrome. 61
32168056 2021
19
Kawasaki syndrome: role of superantigens revisited. 61
32770775 2021
20
Ruptured coronary artery aneurysm mimicking as a giant mediastinal mass. 61
33496317 2021
21
Giant coronary artery aneurysm masquerading as an anterior mediastinal mass. 61
32897501 2021
22
Update on SARS-CoV-2 infection in children. 61
33616026 2021
23
[Safety of warfarin therapy in children with coronary aneurysm due to Kawasaki disease]. 61
33548954 2021
24
Rare case of Kawasaki disease with cardiac tamponade and giant coronary artery aneurysms. 61
33568249 2021
25
Decreased serum Annexin A1 levels in Kawasaki disease with coronary artery aneurysm. 61
32316027 2021
26
Neonatal Kawasaki disease: Case report and literature review. 61
33607798 2021
27
[Middle and long-term follow-up of 101 children with giant coronary artery aneurysm of Kawasaki disease]. 61
33548955 2021
28
Surgical exclusion of an idiopathic saccular aneurysm in the left main trunk of the coronary artery. 61
33606095 2021
29
Unusual Presentation of a Rapidly Progressive Coronary Artery Pseudoaneurysm after Drug Eluting Stent Placement. 61
33738156 2021
30
Reply to Prophylactic Anticoagulation: Comment on the ACR Guidance for Management of Multisystem Inflammatory Syndrome in Children. 61
33586355 2021
31
Reversible Coronary Artery Aneurysm With Delayed Anti-inflammatory Therapy in Multisystem Inflammatory Syndrome in Children. 61
33649746 2021
32
Coronary artery aneurysms: outcomes following medical, percutaneous interventional and surgical management. 61
33568555 2021
33
Coronary Artery Aneurysms as a Feature of Granulomatosis With Polyangiitis. 61
33384297 2021
34
CT Angiography or Cardiac MRI for Detection of Coronary Artery Aneurysms in Kawasaki Disease. 61
33614558 2021
35
Diagnosis of Coronary Artery Abnormalities in Patients with Kawasaki Disease According to Established Guidelines and Z Score Formulas. 61
33422668 2021
36
All That Childhood Coronary Artery Aneurysms Are Not Kawasaki Disease! 61
32845458 2021
37
Cardiac magnetic resonance feature tracking of the right ventricle in convalescent Kawasaki disease in a large single center. 61
33179816 2021
38
Autoimmune Hemolytic Anemia and Immune Thrombocytopenia: A Unique Presentation of Kawasaki Disease. 61
33728087 2021
39
Patient Characteristics, Patterns, and Repair of Aneurysms in Human Immunodeficiency Virus-Positive Patients. 61
32599105 2021
40
Efficacy of infliximab in the treatment of Kawasaki disease: A systematic review and meta-analysis. 61
33235624 2021
41
Targeted Use of Prednisolone with Intravenous Immunoglobulin for Kawasaki Disease. 61
33341911 2021
42
COVID-19 and multisystem inflammatory syndrome in children: A systematic review and meta-analysis. 61
33428826 2021
43
Coronary aneurysms, myocardial dysfunction, and shock in a COVID-19 child, role of ECMO, immunomodulation, and cardiac CT. 61
33504377 2021
44
Spectrum of Imaging Findings at Chest Radiography, US, CT, and MRI in Multisystem Inflammatory Syndrome in Children Associated with COVID-19. 61
32584166 2021
45
Aortopulmonary window, left coronary artery aneurysm, and redundant aortic valve leaflet in a calf: the use of multimodal imaging to diagnose congenital heart disease. 61
33561812 2021
46
Coronary artery vasculitis: a review of current literature. 61
33407141 2021
47
Congenital Coronary Aneurysm: Unusual Presentation of Myocardial Ischemia in Children. 61
31023146 2021
48
COVID-19-Associated Multisystem Inflammatory Syndrome Complicated with Giant Coronary Artery Aneurysm. 61
33505752 2021
49
Childhood Multisystem Inflammatory Syndrome: An Emerging Disease with Prominent Cardiovascular Involvement-A Scoping Review. 61
33437929 2021
50
Impact of Platelet Glycoprotein Ia/IIa C807T Gene Polymorphisms on Coronary Artery Aneurysms of KD Patients. 61
33708441 2021

Variations for Coronary Artery Aneurysm

Expression for Coronary Artery Aneurysm

Search GEO for disease gene expression data for Coronary Artery Aneurysm.

Pathways for Coronary Artery Aneurysm

Pathways related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 MMP7 MMP3 MMP13 MMP12 MMP1
2
Show member pathways
12.86 MMP7 MMP3 MMP13 MMP12 MMP1
3
Show member pathways
12.47 MMP7 MMP3 MMP13
4
Show member pathways
12.21 MMP7 MMP3 MMP13 MMP12 MMP1
5
Show member pathways
11.99 MMP3 MMP13 MMP1
6
Show member pathways
11.93 MMP3 MMP13 MMP1
7 11.76 MMP7 MMP12 MMP1
8 11.72 MMP12 MMP1
9 11.67 MMP3 MMP13
10 11.63 MMP3 MMP1
11 11.54 MMP3 MMP1
12 11.38 MMP7 MMP3 MMP13
13
Show member pathways
11.37 MMP7 MMP3
14 11.36 MMP7 MMP13
15
Show member pathways
11.35 MMP7 MMP3 MMP13 MMP12 MMP1
16
Show member pathways
11.32 MMP3 MMP1
17 11.1 MMP3 MMP1
18 11 MMP3 MMP13
19 10.81 MMP7 MMP3 MMP13 MMP12 MMP1
20 10.69 MMP7 MMP1

GO Terms for Coronary Artery Aneurysm

Cellular components related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 MMP7 MMP3 MMP13 MMP12
2 extracellular region GO:0005576 9.35 MMP7 MMP3 MMP13 MMP12 MMP1
3 extracellular matrix GO:0031012 9.02 MMP7 MMP3 MMP13 MMP12 MMP1

Biological processes related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.72 MMP7 MMP3 MMP13 MMP12 MMP1
2 extracellular matrix organization GO:0030198 9.55 MMP7 MMP3 MMP13 MMP12 MMP1
3 response to amyloid-beta GO:1904645 9.43 MMP3 MMP13 MMP12
4 positive regulation of protein complex assembly GO:0031334 9.4 MMP3 MMP1
5 cellular response to UV-A GO:0071492 9.37 MMP3 MMP1
6 extracellular matrix disassembly GO:0022617 9.35 MMP7 MMP3 MMP13 MMP12 MMP1
7 collagen catabolic process GO:0030574 9.02 MMP7 MMP3 MMP13 MMP12 MMP1

Molecular functions related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.85 MMP7 MMP3 MMP13 MMP12 MMP1
2 hydrolase activity GO:0016787 9.77 MMP7 MMP3 MMP13 MMP12 MMP1
3 zinc ion binding GO:0008270 9.72 MMP7 MMP3 MMP13 MMP12 MMP1
4 peptidase activity GO:0008233 9.65 MMP7 MMP3 MMP13 MMP12 MMP1
5 serine-type endopeptidase activity GO:0004252 9.58 MMP7 MMP3 MMP1
6 metallopeptidase activity GO:0008237 9.55 MMP7 MMP3 MMP13 MMP12 MMP1
7 collagen binding GO:0005518 9.43 MMP13 MMP12
8 metalloendopeptidase activity GO:0004222 9.35 MMP7 MMP3 MMP13 MMP12 MMP1
9 endopeptidase activity GO:0004175 9.02 MMP7 MMP3 MMP13 MMP12 MMP1

Sources for Coronary Artery Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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