MCID: CRN074
MIFTS: 46

Coronary Artery Aneurysm

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Coronary Artery Aneurysm

MalaCards integrated aliases for Coronary Artery Aneurysm:

Name: Coronary Artery Aneurysm 52 32
Coronary Artery Aneurysms 54
Coronary Aneurysm 71

Classifications:



External Ids:

ICD10 32 I25.4
UMLS 71 C0010051

Summaries for Coronary Artery Aneurysm

MalaCards based summary : Coronary Artery Aneurysm, also known as coronary artery aneurysms, is related to aortic aneurysm, familial abdominal, 1 and arteries, anomalies of. An important gene associated with Coronary Artery Aneurysm is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are TNFR1 Pathway and Integrin Pathway. The drugs Aspirin and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, lymph node and endothelial, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 74 Coronary artery aneurysm is an abnormal dilatation of part of the coronary... more...

Related Diseases for Coronary Artery Aneurysm

Diseases in the Coronary Artery Aneurysm family:

Congenital Coronary Artery Aneurysm

Diseases related to Coronary Artery Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 30.1 MMP3 MMP13 MMP12 MMP1 CCL2
2 arteries, anomalies of 30.1 VCAM1 LEP CCL2 AGT ADIPOQ
3 pericarditis 30.0 RETN LEP ADIPOQ
4 atherosclerosis susceptibility 29.7 VCAM1 RETN LEP CCL2 ADIPOQ
5 marfan syndrome 29.5 MMP3 MMP12 MMP1
6 lipid metabolism disorder 29.5 RETN LEP CCL2 ADIPOQ
7 end stage renal failure 29.3 RETN LEP AGT ADIPOQ
8 leptin deficiency or dysfunction 29.2 RETN LEP ADIPOQ
9 kidney disease 29.1 VCAM1 RETN LEP CCL2 AGT ADIPOQ
10 arthritis 29.1 VCAM1 MMP3 MMP13 MMP12 MMP1 CCL2
11 vascular disease 28.8 VCAM1 RETN MMP3 LEP CCL2 AGT
12 myocardial infarction 28.4 VCAM1 RETN MMP7 MMP3 MMP13 MMP1
13 body mass index quantitative trait locus 11 28.4 VCAM1 RETN MMP3 LEP CCL2 AGT
14 rheumatoid arthritis 27.4 VCAM1 RETN PRRC2A MMP3 MMP13 MMP12
15 congenital coronary artery aneurysm 12.6
16 kawasaki disease 12.1
17 aneurysm 11.3
18 coronary artery dissection, spontaneous 11.0
19 coronary aneurysm 10.9
20 vasculitis 10.8
21 ischemia 10.6
22 cardiac tamponade 10.6
23 coronary stenosis 10.6
24 acute myocardial infarction 10.6
25 aortic aneurysm 10.5
26 inferior myocardial infarction 10.5
27 angina pectoris 10.5
28 intermediate coronary syndrome 10.4
29 endocarditis 10.4
30 congestive heart failure 10.4
31 thrombosis 10.4
32 hemopericardium 10.4
33 hypogonadism, male 10.4 LEP KLK3
34 palladium allergic contact dermatitis 10.3 CCL2 CCL17
35 pericardial effusion 10.3
36 coronary artery anomaly 10.3
37 hyperlipoproteinemia, type iii 10.3
38 exanthem 10.3
39 mitral valve insufficiency 10.3
40 coronary thrombosis 10.3
41 polyarteritis nodosa 10.3
42 superior limbic keratoconjunctivitis 10.3 MMP3 MMP1
43 cardiac arrest 10.3
44 heart septal defect 10.3
45 cardiogenic shock 10.3
46 cardiac conduction defect 10.3
47 infective endocarditis 10.3
48 aortic valve insufficiency 10.3
49 sex development disorder 10.2 LEP KLK3 ADIPOQ
50 neurofibromatosis, type iv, of riccardi 10.2

Comorbidity relations with Coronary Artery Aneurysm via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Mitral Valve Disease

Graphical network of the top 20 diseases related to Coronary Artery Aneurysm:



Diseases related to Coronary Artery Aneurysm

Symptoms & Phenotypes for Coronary Artery Aneurysm

MGI Mouse Phenotypes related to Coronary Artery Aneurysm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ABHD16A ADIPOQ AGT BAG6 ITPR3 LEP
2 immune system MP:0005387 9.97 ABHD16A ADIPOQ AGT CCL17 CCL2 LEP
3 reproductive system MP:0005389 9.61 ABHD16A AGT ITPR3 LEP MMP12 PLCB1
4 skeleton MP:0005390 9.28 ABHD16A ADIPOQ ITPR3 LEP MMP13 MMP3

Drugs & Therapeutics for Coronary Artery Aneurysm

Drugs for Coronary Artery Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2 Antirheumatic Agents Phase 4
3 Fibrinolytic Agents Phase 4
4 Antipyretics Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Analgesics Phase 4
8 Cyclooxygenase Inhibitors Phase 4
9 Anti-Inflammatory Agents Phase 4
10
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
11 Albumin-Bound Paclitaxel Phase 2, Phase 3
12 Antimitotic Agents Phase 2, Phase 3
13
Atorvastatin Approved Phase 2 134523-00-5 60823
14
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
15
Infliximab Approved Phase 2 170277-31-3
16 Hypolipidemic Agents Phase 2
17 Anticholesteremic Agents Phase 2
18 Antimetabolites Phase 2
19 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
20 Lipid Regulating Agents Phase 2
21 Anti-Infective Agents Phase 2
22 Gastrointestinal Agents Phase 2
23 Antimalarials Phase 2
24 Dermatologic Agents Phase 2
25 Anti-Bacterial Agents Phase 2
26 Antiparasitic Agents Phase 2
27 Antiprotozoal Agents Phase 2
28
Diltiazem Approved, Investigational 42399-41-7 39186
29
Clopidogrel Approved 113665-84-2, 120202-66-6 60606
30
Warfarin Approved 81-81-2 6691 54678486
31
Calcium Approved, Nutraceutical 7440-70-2 271
32 Hormones
33 Vasodilator Agents
34 Antihypertensive Agents
35 Calcium, Dietary
36 calcium channel blockers
37 Yellow Dock
38 Platelet Aggregation Inhibitors
39 Neurotransmitter Agents
40 Purinergic P2Y Receptor Antagonists
41 Anticoagulants

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
2 Trial of Pulse Steroid Therapy in Kawasaki Disease (A Trial Conducted by the Pediatric Heart Network) Completed NCT00132080 Phase 3 Steroids
3 TAXUS V: De Novo Lesion: A Randomized, Double-blind Trial to Assess TAXUS Paclitaxel-Eluting Coronary Stents, SR Formulation, in the Treatment of De Novo Coronary Lesions Completed NCT00301522 Phase 2, Phase 3
4 An Open Label, Non-comparative Phase II Trial to Evaluate the Effects of Atorvastatin on the Persistent Coronary Arterial Aneurysm in Children With Kawasaki Disease: Safety and Efficacy Unknown status NCT02114099 Phase 2 Atorvastatin
5 Prevention of Coronary Aneurysms in Kawasaki Syndrome Completed NCT00000520 Phase 2 immunoglobulins, intravenous;aspirin
6 Phase 2 Study to Assess the Efficacy and Safety of Doxycycline in Preventing Coronary Artery Aneurysm Formation and Progression Recruiting NCT01917721 Phase 2 Doxycycline;Placebo
7 Study of Efficacy and Safety of Canakinumab in Pediatric Patients With Kawasaki Disease Withdrawn NCT02980263 Phase 2 Canakinumab
8 Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries Unknown status NCT00548457
9 Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method In Patients Undergoing Coronary Angiography Unknown status NCT02818127
10 Etiology Study of Kawasaki Disease--A Prospective Household and Case Control Study Unknown status NCT00154596
11 Effects of Emotional Status on Coronary Flow in Patients Undergoing Coronary Angiography:Multicenter TIMI Frame Count Assessment Study (STRAIN-TIMI Study) Unknown status NCT02831153
12 Coronary Artery Aneurysms: Incidence, Management and Long Term Prognosis Completed NCT02563626
13 Short Term Effect of Diltiazem on Myocardial Perfusion in Patients With Isolated Coronary Artery Ectasia- a Prospective Clinical Study Completed NCT02024919 intracoronary administration of diltiazem;intracoronary injection of 5 mL saline
14 Genetic Determinants of Kawasaki Disease for Susceptibility and Outcome Recruiting NCT03861130
15 Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES) Recruiting NCT00006150
16 Coronary Artery Ectasia in Elective Coronary Angiography : Predictors, Outcomes and Management Not yet recruiting NCT03896321 Antiplatelet Agents;Anticoagulants
17 A Review of the Diagnosis, Treatment and Outcomes of Children With Critical Congenital Heart Defects Terminated NCT00208689

Search NIH Clinical Center for Coronary Artery Aneurysm

Genetic Tests for Coronary Artery Aneurysm

Anatomical Context for Coronary Artery Aneurysm

MalaCards organs/tissues related to Coronary Artery Aneurysm:

40
Heart, Lymph Node, Endothelial, Kidney, T Cells, Neutrophil, Whole Blood

Publications for Coronary Artery Aneurysm

Articles related to Coronary Artery Aneurysm:

(show top 50) (show all 1906)
# Title Authors PMID Year
1
Coronary artery aneurysms, insights from the international coronary artery aneurysm registry (CAAR). 61
31378382 2020
2
One year in review: Kawasaki disease. 61
31599798 2020
3
Coronary artery assessment in Kawasaki disease with dual-source CT angiography to uncover vascular pathology. 61
31428828 2020
4
Multiple Coronary Artery Aneurysms in Alport Syndrome. 61
31786532 2019
5
A rare case of stent-assisted coil embolization of coronary artery aneurysm in the left main trigeminal position: Case report. 61
31852073 2019
6
Giant right coronary artery aneurysm - A rare presentation. 61
31799794 2019
7
History and Future of Treatment for Acute Stage Kawasaki Disease. 61
31845551 2019
8
Coronary artery aneurysm in Kawasaki disease: from multimodality imaging. 61
31821196 2019
9
Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm. 61
31561960 2019
10
Systemic Artery Aneurysms and Kawasaki Disease. 61
31732547 2019
11
Myocardial infarction revealed a giant right coronary artery aneurysm. 61
31730735 2019
12
A case of giant right coronary artery aneurysm due to IgG4-related disease. 61
31848902 2019
13
Large Aneurysmal Rupture of Coronary-Pulmonary Artery Fistula After Buffalo Goring. 61
31848328 2019
14
Giant right coronary artery aneurysm presenting as an STEMI. 61
31700600 2019
15
Large Right Coronary Artery Aneurysm. 61
31671066 2019
16
Incidental finding of giant coronary artery aneurysm. 61
31765008 2019
17
Giant right coronary artery aneurysm: Insights from the experience of a peripheral national health system institute. 61
31740364 2019
18
Multimodality imaging in preparation for surgery of coronary to pulmonary arterial fistulas complicated with a huge coronary aneurysm. 61
31621955 2019
19
Fistula occlusion and ligation for a giant right coronary artery aneurysm concurrent with right atrial fistula: a case report. 61
31703594 2019
20
Left circumflex artery aneurysm with fistula to the coronary sinus. 61
31728834 2019
21
Kawasaki Disease Presenting as Acute Acalculous Cholecystitis. 61
31763594 2019
22
Anti-thrombosis management of patients with Kawasaki disease: Results from an international survey. 61
31753581 2019
23
Out-of-hospital cardiac arrest in a young adult survivor with sequelae of childhood Kawasaki disease: A case report. 61
31750341 2019
24
Von Willebrand factor parameters as potential biomarkers for disease activity and coronary artery lesion in patients with Kawasaki disease. 61
31760507 2019
25
Long-term follow-up of covered stent implantation for various coronary artery diseases. 61
30773795 2019
26
Exclusion of a coronary aneurysm with a polyurethane-covered stent. 61
31582669 2019
27
Very Early Coronary Artery Aneurysm After Primary Percutaneous Coronary Intervention in Patient With HIV and Thrombophilia. 61
31636800 2019
28
Surgical management of multiple giant coronary artery aneurysms determining myocardial ischemia. 61
31600409 2019
29
Utilization and outcomes of polytetrafluoroethylene covered stents in patients with coronary artery perforation and coronary artery aneurysm: Single center 15-year experience. 61
31429192 2019
30
Giant right coronary artery aneurysm on cardiac CT. 61
31652091 2019
31
A case of coronary-pulmonary artery fistula with coronary artery aneurysm detected for Kawasaki disease remote phase. 61
31032930 2019
32
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation. 61
31611559 2019
33
A Pediatric Case Report of Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis With Pericardial Effusion and Multiple Coronary Artery Aneurysms. 61
31688637 2019
34
Coronary Artery Aneurysm after Second-Generation Drug-Eluting Stent Implantation. 61
31433580 2019
35
Rupture of a Coronary Artery Aneurysm and Fistula to the Pulmonary Artery. 61
31522553 2019
36
Scarce case of giant coronary artery aneurysm combined with huge pseudoaneurysm causing cardiac tamponade. 61
30226015 2019
37
Giant coronary artery aneurysm in a patient with LEOPARD syndrome. 61
31369669 2019
38
A stent fracture associated with giant coronary aneurysm. 61
31564023 2019
39
A Giant Right Coronary Artery Aneurysm Leading to Tricuspid Stenosis. 61
30872099 2019
40
Double-layer bare metal stents in the treatment of coronary artery aneurysm: experience and outcomes in nine patients. 61
30834896 2019
41
Large Aneurysm of the Left Main Coronary Artery: A Case Report. 61
31543742 2019
42
Impact of Socioeconomic Status on Outcomes of Patients with Kawasaki Disease. 61
31229318 2019
43
Understanding the importance of cerebrovascular involvement in Kawasaki disease. 61
31096739 2019
44
Huge coronary artery aneurysm causing myocardial infarction in Behcet disease. 61
30874789 2019
45
Multi-vessel coronary artery aneurysms in a patient with Parry Romberg syndrome: a case report. 61
31660479 2019
46
Usefulness of multimodality cardiac imaging in a patient with ST elevation myocardial infarction caused by two giant coronary artery aneurysms. 61
31383682 2019
47
Percutaneous intervention of coronary aneurysm. 61
31523002 2019
48
A novel safe method for treatment of giant coronary artery aneurysm: Wire Looping Technique. 61
30633028 2019
49
Alternative Approach for the Surgical Treatment of Left Main Coronary Artery Aneurysm. 61
30684476 2019
50
A time bomb defused, in time! Incidental giant right coronary artery aneurysm. 61
31132101 2019

Variations for Coronary Artery Aneurysm

Expression for Coronary Artery Aneurysm

Search GEO for disease gene expression data for Coronary Artery Aneurysm.

Pathways for Coronary Artery Aneurysm

Pathways related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 TRAF6 PLCB4 PLCB1 ITPR3 CCL2 AGT
2
Show member pathways
12.83 VCAM1 PLCB4 PLCB1 MMP7 MMP3 MMP13
3 12.73 TRAF6 PLCB4 PLCB1 MMP1 KLK3 AGT
4
Show member pathways
12.61 VCAM1 MMP7 MMP3 MMP13 MMP12 MMP1
5
Show member pathways
12.59 PLCB4 PLCB1 MMP13 MMP1 ITPR3
6
Show member pathways
12.51 TRAF6 PLCB4 PLCB1 ITPR3 AGT
7
Show member pathways
12.41 PLCB4 PLCB1 ITPR3 AGT
8
Show member pathways
12.34 TRAF6 PLCB4 PLCB1 ITPR3
9 12.31 TRAF6 PLCB4 PLCB1 ITPR3
10
Show member pathways
12.15 MMP3 MMP13 MMP1 CCL2
11 12.09 TRAF6 PLCB4 PLCB1 ITPR3 CCL2
12 11.98 RETN LEP AGT ADIPOQ
13
Show member pathways
11.97 TRAF6 MMP3 MMP13 MMP1 CCL2 CCL17
14 11.93 VCAM1 MMP3 MMP13 KLK3
15 11.87 VCAM1 MMP3 MMP1 CCL2
16 11.86 PLCB4 PLCB1 ITPR3
17 11.84 PLCB4 PLCB1 ITPR3
18 11.82 PLCB4 PLCB1 MMP13 ITPR3
19 11.79 MMP3 MMP1 CCL2
20 11.76 PLCB4 PLCB1 ITPR3
21 11.72 VCAM1 PLCB4 PLCB1 CCL2 AGT
22 11.71 MMP7 MMP3 MMP13 CCL2
23 11.66 MMP3 CCL2 CCL17
24
Show member pathways
11.65 MMP7 MMP3 MMP13 MMP12 MMP1
25
Show member pathways
11.62 TRAF6 MMP7 MMP3
26 11.6 PLCB4 PLCB1 ITPR3
27 11.57 PLCB4 PLCB1 ITPR3
28 11.54 PLCB4 PLCB1 ITPR3 AGT
29 11.52 TRAF6 PLCB4 PLCB1
30
Show member pathways
11.47 VCAM1 TRAF6 MMP3 MMP1
31 11.34 PLCB4 PLCB1 MMP13
32 11.31 VCAM1 PLCB4 PLCB1
33 11.27 PLCB4 PLCB1 ITPR3
34 10.9 MMP7 MMP1
35 10.89 MMP7 MMP3 MMP13 MMP12 MMP1 KLK3
36 10.86 VCAM1 CCL2

GO Terms for Coronary Artery Aneurysm

Cellular components related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 RETN MMP7 MMP3 MMP13 MMP12 MMP1
2 extracellular matrix GO:0031012 9.55 MMP7 MMP3 MMP13 MMP12 MMP1
3 extracellular space GO:0005615 9.4 VCAM1 RETN MMP7 MMP3 MMP13 MMP12

Biological processes related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.88 MMP7 MMP3 MMP13 MMP12 MMP1 KLK3
2 aging GO:0007568 9.73 VCAM1 RETN MMP7 AGT
3 cytokine-mediated signaling pathway GO:0019221 9.72 VCAM1 TRAF6 MMP3 MMP1 CCL2
4 response to nutrient GO:0007584 9.69 VCAM1 LEP ADIPOQ
5 positive regulation of T cell proliferation GO:0042102 9.67 VCAM1 TRAF6 LEP
6 response to nutrient levels GO:0031667 9.65 MMP7 LEP ADIPOQ
7 release of sequestered calcium ion into cytosol GO:0051209 9.63 PLCB4 PLCB1 ITPR3
8 extracellular matrix organization GO:0030198 9.63 VCAM1 MMP7 MMP3 MMP13 MMP12 MMP1
9 positive regulation of cellular protein metabolic process GO:0032270 9.54 AGT ADIPOQ
10 inositol trisphosphate biosynthetic process GO:0032959 9.52 PLCB4 PLCB1
11 response to amyloid-beta GO:1904645 9.43 MMP3 MMP13 MMP12
12 positive regulation of developmental growth GO:0048639 9.37 PLCB1 LEP
13 extracellular matrix disassembly GO:0022617 9.35 MMP7 MMP3 MMP13 MMP12 MMP1
14 collagen catabolic process GO:0030574 9.02 MMP7 MMP3 MMP13 MMP12 MMP1

Molecular functions related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.97 PLCB4 PLCB1 MMP7 MMP3 MMP13 MMP12
2 zinc ion binding GO:0008270 9.93 TRAF6 MMP7 MMP3 MMP13 MMP12 MMP1
3 peptidase activity GO:0008233 9.85 MMP7 MMP3 MMP13 MMP12 MMP1 KLK3
4 signaling receptor binding GO:0005102 9.83 LEP CCL2 CCL17 BAG6 ADIPOQ
5 serine-type endopeptidase activity GO:0004252 9.71 MMP7 MMP3 MMP1 KLK3
6 hormone activity GO:0005179 9.56 RETN LEP AGT ADIPOQ
7 phospholipase C activity GO:0004629 9.48 PLCB4 PLCB1
8 endopeptidase activity GO:0004175 9.46 MMP3 MMP12 MMP1 KLK3
9 metallopeptidase activity GO:0008237 9.35 MMP7 MMP3 MMP13 MMP12 MMP1
10 metalloendopeptidase activity GO:0004222 9.02 MMP7 MMP3 MMP13 MMP12 MMP1

Sources for Coronary Artery Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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