Coronary Artery Anomaly (CHD)

Categories: Blood diseases, Cardiovascular diseases, Genetic diseases, Respiratory diseases

Aliases & Classifications for Coronary Artery Anomaly

MalaCards integrated aliases for Coronary Artery Anomaly:

Name: Coronary Artery Anomaly 38 12 15
Coronary Artery Disease 38 12 37 29 13 55 6 43 44 15 63 73
Coronary Artery Disease, Susceptibility to 13 6
Coronary Arteriosclerosis 12 73
Coronary Heart Disease 12 73
Myocardial Ischemia 44 73
Coronary Disease 12 44
Congenital Anomaly of Coronary Artery 12
Coronary Artery Anomaly, Congenital 12
Coronary Artery Abnormality 12
Coronary Syndrome 15
Chd 12


Summaries for Coronary Artery Anomaly

MedlinePlus : 43 Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death in the United States in both men and women. CAD happens when the arteries that supply blood to heart muscle become hardened and narrowed. This is due to the buildup of cholesterol and other material, called plaque, on their inner walls. This buildup is called atherosclerosis. As it grows, less blood can flow through the arteries. As a result, the heart muscle can't get the blood or oxygen it needs. This can lead to chest pain (angina) or a heart attack. Most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage. Over time, CAD can also weaken the heart muscle and contribute to heart failure and arrhythmias. Heart failure means the heart can't pump blood well to the rest of the body. Arrhythmias are changes in the normal beating rhythm of the heart. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Coronary Artery Anomaly, also known as coronary artery disease, is related to coronary heart disease 1 and intermediate coronary syndrome, and has symptoms including tremor, angina pectoris and edema. An important gene associated with Coronary Artery Anomaly is PON1 (Paraoxonase 1), and among its related pathways/superpathways are cGMP-PKG signaling pathway and Wnt signaling pathway. The drugs Infliximab and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

PubMed Health : 63 About coronary artery disease: Coronary artery disease (CAD, also called coronary heart disease, or CHD) is caused by the narrowing of the large blood vessels that supply the heart with oxygen. These are called coronary arteries. Arteries that have become extremely narrow can cause shortness of breath and chest pain during physical activity. If a coronary artery suddenly becomes completely blocked, it can result in a heart attack.CAD can also lead to other health problems like heart failure or heart rhythm problems. Various treatments can be used to reduce the symptoms and the risk of complications.

Wikipedia : 76 Coronary artery anomalies (or malformation of coronary vessels) are congenital abnormalities in the... more...

Related Diseases for Coronary Artery Anomaly

Diseases in the Coronary Artery Anomaly family:

Coronary Artery Disease, Autosomal Dominant, 1 Coronary Artery Disease, Autosomal Dominant 2

Diseases related to Coronary Artery Anomaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 700)
# Related Disease Score Top Affiliating Genes
1 coronary heart disease 1 34.2 ACE ADRB1 APOA1 APOB CRP EDN1
2 intermediate coronary syndrome 33.5 ACE CRP MB PIK3C2A PLAT TNNI3
3 hypercholesterolemia, familial 32.4 ACE APOA1 APOB CRP NOS3 PON1
4 diabetes mellitus 31.1 ACE APOA1 APOB CRP EDN1 IRS1
5 diabetes mellitus, noninsulin-dependent 30.9 ACE APOA1 APOB CRP EDN1 IRS1
6 systolic heart failure 30.8 ACE ADRB1 CRP EDN1 NPPB
7 carotid artery disease 30.6 ACE APOA1 APOB CRP
8 lipid metabolism disorder 30.6 ACE APOA1 APOB CRP SERPINE1
9 peripheral vascular disease 30.6 ACE APOA1 APOB CRP PLAT SERPINE1
10 cardiogenic shock 30.6 NPPB PIK3C2A PLAT
11 tetralogy of fallot 30.6 CRP EDN1 GJA1 NPPA NPPB
12 cerebrovascular disease 30.6 ACE APOA1 APOB CRP PLAT PON1
13 end stage renal failure 30.5 ACE APOB CRP
14 congestive heart failure 30.5 ACE ADRB1 EDN1 KNG1 NPPA NPPB
15 impotence 30.5 EDN1 KNG1 NOS3
16 sleep apnea 30.5 ACE CRP EDN1 NOS3 NPPB
17 inferior myocardial infarction 30.5 NPPB PIK3C2A PLAT TET1
18 atrial fibrillation 30.5 ACE ADRB1 CRP GJA1 NPPA NPPB
19 mitral valve insufficiency 30.5 ACE NPPA NPPB
20 kidney disease 30.5 ACE CRP EDN1 NOS3 NPPA NPPB
21 limb ischemia 30.5 ACE EDN1 NOS3 TNNI3
22 mitral valve disease 30.4 ACE NOS3 NPPA
23 cardiac arrest 30.4 ACE NPPB PIK3C2A
24 stroke, ischemic 30.4 ACE APOB CRP NOS3 PLAT PON1
25 central serous chorioretinopathy 30.4 PLAT SERPINE1
26 coronary stenosis 30.4 ACE APOA1 APOB CRP NPPB PIK3C2A
27 chronic kidney failure 30.4 ACE APOB CRP EDN1 NOS3 NPPA
28 vascular disease 30.3 ACE APOA1 APOB CRP EDN1 KNG1
29 gas gangrene 30.3 MB PIK3C2A TNNI3
30 peripheral artery disease 30.3 ACE APOB CRP NOS3
31 infective endocarditis 30.3 CRP SERPINE1 TNNI3
32 glucose intolerance 30.2 APOB CRP IRS1
33 intermittent claudication 30.2 ACE CRP SERPINE1
34 microvascular complications of diabetes 5 30.2 ACE NOS3 PON1 SERPINE1
35 endocarditis 30.2 CRP PIK3C2A PLAT TNNI3
36 maturity-onset diabetes of the young, type 1 30.2 ACE CRP IRS1 SERPINE1
37 aortic valve insufficiency 30.2 ACE NPPB PON1
38 diastolic heart failure 30.2 ACE NOS3 NPPA NPPB
39 pulmonary embolism 30.2 CRP FABP3 NPPB PLAT SERPINE1 TNNI3
40 ischemia 30.2 ACE EDN1 GJA1 KNG1 MB NOS3
41 orthostatic intolerance 30.2 ADRB1 EDN1 NOS3
42 pulmonary hypertension 30.2 ACE EDN1 NOS3 NPPA NPPB PLAT
43 arteriosclerosis 30.2 ACE APOA1 APOB CRP EDN1 PON1
44 pulmonary edema 30.2 ACE CRP EDN1 NOS3 NPPA NPPB
45 aortic coarctation 30.2 ACE ADRB1 EDN1 NOS3
46 ischemic heart disease 30.1 ACE APOA1 APOB CRP NOS3 NPPB
47 atherosclerosis susceptibility 30.1 APOA1 APOB CRP NOS3 PON1 SERPINE1
48 left bundle branch hemiblock 30.1 ACE NPPB TNNI3
49 myocarditis 30.1 MB NPPB TNNI3
50 chronic thromboembolic pulmonary hypertension 30.1 CRP EDN1 NPPB

Graphical network of the top 20 diseases related to Coronary Artery Anomaly:

Diseases related to Coronary Artery Anomaly

Symptoms & Phenotypes for Coronary Artery Anomaly

UMLS symptoms related to Coronary Artery Anomaly:

tremor, angina pectoris, edema, chest pain, equilibration disorder, other and unspecified angina pectoris, substernal pain

MGI Mouse Phenotypes related to Coronary Artery Anomaly:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 ACE ADRB1 APOA1 APOB CRP EDN1
2 homeostasis/metabolism MP:0005376 10.25 ACE ADRB1 APOA1 APOB CRP EDN1
3 growth/size/body region MP:0005378 10.22 ACE ADRB1 APOB EDN1 GJA1 IRS1
4 cellular MP:0005384 10.2 APOA1 APOB FABP3 GJA1 IRS1 MB
5 endocrine/exocrine gland MP:0005379 10.09 ACE ADRB1 APOA1 EDN1 GJA1 IRS1
6 hematopoietic system MP:0005397 10.07 ACE GJA1 IRS1 MB NOS3 NPPA
7 adipose tissue MP:0005375 10.04 ACE ADRB1 FABP3 IRS1 NOS3 PIK3C2A
8 mortality/aging MP:0010768 10 ACE ADRB1 APOB EDN1 FABP3 GJA1
9 liver/biliary system MP:0005370 9.8 ACE APOA1 APOB FABP3 IRS1 NOS3
10 muscle MP:0005369 9.7 ADRB1 APOB EDN1 FABP3 GJA1 IRS1
11 respiratory system MP:0005388 9.17 GJA1 MB NOS3 PLAT SERPINE1 TET1

Drugs & Therapeutics for Coronary Artery Anomaly

PubMedHealth treatment related to Coronary Artery Anomaly: 63

The main goals of treatment for CAD are to relieve symptoms and prevent complications.Medication can reduce the symptoms and restrictions in everyday life caused by stable angina. Beta blockers, calcium channel blockers and nitrates are used for this purpose. If that doesn't help, doctors often try to widen the narrowed coronary artery with a procedure using a cardiac catheter. If the arteries are severely narrowed, or if several blood vessels are affected, bypass surgery may be considered. This involves taking a blood vessel from elsewhere in the body and using it to redirect blood around the blocked coronary artery (bypassing it).There are things you can do on your own to help prevent complications like a heart attack or heart failure: eating a healthy diet and getting enough exercise are two examples. If you smoke, you could try to give it up. Also, there are a number of different medications that can prevent complications and increase life expectancy. These include the following:Low doses of acetylsalicylic acid (the drug in medicines like "Aspirin") to prevent blood clotsStatins to protect the blood vesselsBeta blockers to reduce the strain on the heart (especially in people with heart failure or high blood pressure)

Drugs for Coronary Artery Anomaly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Infliximab Approved Phase 3 170277-31-3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 alanine Phase 3
8 Dermatologic Agents Phase 3
9 gamma-Globulins Phase 3
10 Immunologic Factors Phase 3
11 Immunoglobulins, Intravenous Phase 3
12 Immunoglobulins Phase 3
13 Antibodies Phase 3
14 Gastrointestinal Agents Phase 3
15 Antirheumatic Agents Phase 3,Phase 1,Phase 2
16 Rho(D) Immune Globulin Phase 3
17 Protective Agents Phase 3
18 Hormone Antagonists Phase 3
19 Methylprednisolone acetate Phase 3
20 Prednisolone acetate Phase 3
21 Antineoplastic Agents, Hormonal Phase 3
22 Neuroprotective Agents Phase 3
23 Hormones Phase 3
24 Peripheral Nervous System Agents Phase 3
25 Autonomic Agents Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
27 Antiemetics Phase 3
28 Anti-Inflammatory Agents Phase 3
29 glucocorticoids Phase 3
30 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
31 Calcium, Dietary Phase 1, Phase 2,Not Applicable
32 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
33 Anticholesteremic Agents Phase 1, Phase 2
34 Antimetabolites Phase 1, Phase 2
35 Lipid Regulating Agents Phase 1, Phase 2
36 Hypolipidemic Agents Phase 1, Phase 2
37 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Infliximab for Kawasaki Disease Patients Resistant to IVIG : a Multicentre, Prospective, Randomised Trial Completed NCT02298062 Phase 3 Infliximab;IVIG
2 A Trial to Evaluate the Efficacy of Immunoglobulin Plus Steroid for Prevention of Coronary Artery Abnormalities in Taiwanese Refractory Kawasaki Disease (RAST Study) Recruiting NCT03200561 Phase 3 Prednisolone
3 Pharmacokinetics (PK)/Safety Study of Atorvastatin in Children With Kawasaki Disease and Coronary Artery Abnormalities Completed NCT01431105 Phase 1, Phase 2 Atorvastatin
4 Anakinra in Infants and Children With Coronary Artery Abnormalities in Acute Kawasaki Disease Recruiting NCT02179853 Phase 1, Phase 2 Anakinra
5 Coronary Anomalies in Congenital Heart Disease Unknown status NCT01278771
6 Observational Study for Feasibility and Performance of Sub-millisievert Coronary Computed Tomography Angiography (CCTA) for Coronary Artery Anomalies (CAA) in Paediatric Patients Recruiting NCT03194763
7 Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease Recruiting NCT02400229 Not Applicable

Search NIH Clinical Center for Coronary Artery Anomaly

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Coronary Artery Anomaly cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: coronary artery disease

Genetic Tests for Coronary Artery Anomaly

Genetic tests related to Coronary Artery Anomaly:

# Genetic test Affiliating Genes
1 Coronary Artery Disease 29

Anatomical Context for Coronary Artery Anomaly

MalaCards organs/tissues related to Coronary Artery Anomaly:

Heart, Endothelial, Testes, Kidney, Bone, Liver, Lung

Publications for Coronary Artery Anomaly

Articles related to Coronary Artery Anomaly:

(show top 50) (show all 5461)
# Title Authors Year
The role of sphingosine 1 phosphate in coronary artery disease and ischemia reperfusion injury. ( 30341893 )
Management of established coronary artery disease in aircrew without myocardial infarction or revascularisation. ( 30425083 )
Management of established coronary artery disease in aircrew with previous myocardial infarction or revascularisation. ( 30425084 )
Seasonal and circadian patterns of myocardial infarction by coronary artery disease status and sex in the ACTION Registry-GWTG. ( 30217419 )
Comprehensive MS/MS profiling by UHPLC-ESI-QTOF-MS/MS using SWATH data-independent acquisition for the study of platelet lipidomes in coronary artery disease. ( 30482286 )
The challenge of asymptomatic coronary artery disease in aircrew; detecting plaque before the accident. ( 30425082 )
Racial Disparities in the Cardiac Computed Tomography Assessment of Coronary Artery Disease: Does Gender Matter. ( 30520779 )
Urinary 8-iso-prostaglandin F2α as a risk marker for the vulnerability of culprit plaque in diabetic patients with stable coronary artery disease. ( 30553398 )
Clinical utility of circulating interleukin-6 concentrations in the detection of functionally relevant coronary artery disease. ( 30340850 )
Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease. ( 30359818 )
Accuracy of cadmium-zinc-telluride imaging in detecting single and multivessel coronary artery disease: Is there any gender difference? ( 30282601 )
Association of Increased Levels of lncRNA H19 in PBMCs with Risk of Coronary Artery Disease. ( 30124004 )
Droplet digital PCR of serum miR-499, miR-21 and miR-208a for the detection of functionally relevant coronary artery disease. ( 30126654 )
CPAP effects on atherosclerotic plaques in patients with sleep-disordered breathing and coronary artery disease: The ENTERPRISE trial. ( 30177302 )
Clinical impact of high-sensitivity C-reactive protein during follow-up on long-term adverse clinical outcomes in patients with coronary artery disease treated with percutaneous coronary intervention. ( 30001869 )
Novel Biomarkers for Coronary Restenosis Occurrence After Drug-Eluting Stent Implantation in Patients With Diabetes Having Stable Coronary Artery Disease. ( 29716394 )
An imaging pitfall in coronary artery anomaly diagnosis. ( 29912369 )
Revisiting angina pectoris with and without obstructive coronary artery disease. ( 29905817 )
High-Sensitivity Cardiac Troponin I and the Diagnosis of Coronary Artery Disease in Patients With Suspected Angina Pectoris. ( 29444926 )
Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients. ( 29449336 )
The effect of rheumatoid arthritis on the risk of cerebrovascular disease and coronary artery disease in young adults. ( 29861211 )
Could the stress hyperglycemia ratio predict the clinical outcomes of coronary artery disease patients after percutaneous coronary intervention? ( 29407118 )
Saliva and serum biomarkers in periodontitis and coronary artery disease. ( 29972696 )
The associatA+on between serum serglycin level and coronary artery disease severity in patients with stable angina pectoris. ( 29313562 )
Protein biomarkers and coronary microvascular dilatation assessed by rubidium-82 PET in women with angina pectoris and no obstructive coronary artery disease. ( 29981522 )
Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease. ( 29381773 )
Case Image: Superdominant right coronary artery and left anterior descending artery arising from the right coronary sinus: a rare coronary artery anomaly. ( 29339681 )
The correlation between speckle tracking echocardiography and coronary artery disease in patients with suspected stable angina pectoris. ( 29961454 )
Combined operation for thymoma with myasthenia gravis and coronary artery disease in an octogenarian. ( 29924495 )
Significant genetic association of a functional TFPI variant with circulating fibrinogen levels and coronary artery disease. ( 28894953 )
Accuracy of cardiac magnetic resonance imaging to rule out significant coronary artery disease in patients with systolic heart failure of unknown aetiology: Single-centre experience and comprehensive meta-analysis. ( 29861294 )
The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study. ( 29369221 )
Growing evidence for coronary artery disease risk factors in patients with severe hidradenitis suppurativa. ( 29357611 )
Adult-type ALCAPA syndrome: A rare coronary artery anomaly. ( 29749648 )
Single Coronary Artery Anomaly: A Case Report and Review of Literature. ( 29411245 )
Abnormal Repolarization Duration during Everyday Emotional Arousal in Long QT Syndrome and Coronary Artery Disease. ( 29309742 )
Prader-Willi syndrome: a nest for premature coronary artery disease? ( 29437709 )
Association between P2RY12 gene polymorphisms and adverse clinical events in coronary artery disease patients treated with clopidogrel: A systematic review and meta-analysis. ( 29510176 )
Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction. ( 29904441 )
Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: An iPOWER substudy. ( 29436257 )
Is psoriasis a risk factor of angiography-proven coronary artery disease? ( 29956314 )
Review of the 2017 European Society of Cardiology's Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting with ST-Segment Elevation and Focused Update on Dual Antiplatelet Therapy in Coronary Artery Disease Developed in Collaboration with the European Association for Cardio-Thoracic Surgery. ( 30482703 )
Free IGF-1, Intact IGFBP-4, and PicoPAPP-A are Altered in Acute Myocardial Infarction Compared to Stable Coronary Artery Disease and Healthy Controls. ( 30497090 )
Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction. ( 30116144 )
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. ( 30193001 )
Myocardial rupture after small acute myocardial infarction in the absence of coronary artery disease. ( 30223140 )
Low CPNE3 expression is associated with risk of acute myocardial infarction: A feasible genetic marker of acute myocardial infarction in patients with stable coronary artery disease. ( 29297177 )
Use of two-dimensional speckle tracking echocardiography to predict cardiac events: Comparison of patients with acute myocardial infarction and chronic coronary artery disease. ( 29359809 )
Potential associations of testosterone/estradiol ratio, leukocyte hTERT expression and PBMC telomerase activity with aging and the presence of coronary artery disease in men. ( 30179663 )
Effect of sex difference in clinical presentation (stable coronary artery disease vs unstable angina pectoris or non-ST-elevation myocardial infarction vs ST-elevation myocardial infarction) on 2-year outcomes in patients undergoing percutaneous coronary intervention. ( 29023996 )

Variations for Coronary Artery Anomaly

ClinVar genetic disease variations for Coronary Artery Anomaly:

# Gene Variation Type Significance SNP ID Assembly Location
1 TERT TERT, -1327T-C single nucleotide variant Uncertain significance
2 PON1 NM_000446.6(PON1): c.575A> G (p.Gln192Arg) single nucleotide variant risk factor rs662 GRCh37 Chromosome 7, 94937446: 94937446
3 PON1 NM_000446.6(PON1): c.575A> G (p.Gln192Arg) single nucleotide variant risk factor rs662 GRCh38 Chromosome 7, 95308134: 95308134
4 PON1 NM_000446.6(PON1): c.163T> A (p.Leu55Met) single nucleotide variant risk factor rs854560 GRCh37 Chromosome 7, 94946084: 94946084
5 PON1 NM_000446.6(PON1): c.163T> A (p.Leu55Met) single nucleotide variant risk factor rs854560 GRCh38 Chromosome 7, 95316772: 95316772
6 IRS1 NM_005544.2(IRS1): c.2911G> A (p.Gly971Arg) single nucleotide variant risk factor rs1801278 GRCh37 Chromosome 2, 227660544: 227660544
7 IRS1 NM_005544.2(IRS1): c.2911G> A (p.Gly971Arg) single nucleotide variant risk factor rs1801278 GRCh38 Chromosome 2, 226795828: 226795828

Copy number variations for Coronary Artery Anomaly from CNVD:

# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13312 1 1 117600000 Copy number Coronary Disease
2 207742 6 160872504 161007397 Copy number LPA Coronary Disease
3 207743 6 160872504 161007397 Copy number LPA Coronary Disease
4 250037 9 19900000 32800000 Copy number Coronary Disease

Expression for Coronary Artery Anomaly

Search GEO for disease gene expression data for Coronary Artery Anomaly.

Pathways for Coronary Artery Anomaly

Pathways related to Coronary Artery Anomaly according to KEGG:

# Name Kegg Source Accession
1 cGMP-PKG signaling pathway hsa04022
2 Wnt signaling pathway hsa04310

GO Terms for Coronary Artery Anomaly

Cellular components related to Coronary Artery Anomaly according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 ACE APOA1 APOB FABP3 KNG1 MB
2 early endosome GO:0005769 9.71 ADRB1 APOA1 APOB GJA1
3 extracellular region GO:0005576 9.7 ACE APOA1 APOB CRP EDN1 KNG1
4 collagen-containing extracellular matrix GO:0062023 9.65 APOA1 KNG1 NPPA PLAT SERPINE1
5 contractile fiber GO:0043292 9.49 GJA1 TNNI3
6 endocytic vesicle lumen GO:0071682 9.48 APOA1 APOB
7 low-density lipoprotein particle GO:0034362 9.46 APOA1 APOB
8 chylomicron GO:0042627 9.43 APOA1 APOB
9 extracellular space GO:0005615 9.4 ACE APOA1 APOB CRP EDN1 FABP3
10 spherical high-density lipoprotein particle GO:0034366 9.37 APOA1 PON1
11 intermediate-density lipoprotein particle GO:0034363 9.32 APOA1 APOB

Biological processes related to Coronary Artery Anomaly according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.88 EDN1 GJA1 MB TNNI3
2 cellular protein metabolic process GO:0044267 9.83 APOA1 APOB KNG1 NPPA
3 in utero embryonic development GO:0001701 9.8 APOB EDN1 GJA1 NOS3
4 cholesterol homeostasis GO:0042632 9.79 APOA1 APOB FABP3
5 cholesterol metabolic process GO:0008203 9.78 APOA1 APOB PON1
6 response to insulin GO:0032868 9.73 FABP3 IRS1 NPPA
7 response to hypoxia GO:0001666 9.71 EDN1 MB NPPA PLAT
8 response to lipopolysaccharide GO:0032496 9.67 APOB EDN1 GJA1 NOS3
9 response to muscle stretch GO:0035994 9.64 EDN1 NPPA
10 heart contraction GO:0060047 9.64 ACE TNNI3
11 negative regulation of wound healing GO:0061045 9.63 GJA1 SERPINE1
12 positive regulation of renal sodium excretion GO:0035815 9.63 EDN1 NPPB
13 positive regulation of urine volume GO:0035810 9.62 EDN1 NPPB
14 regulation of blood vessel diameter GO:0097746 9.62 ACE NPPB
15 cGMP biosynthetic process GO:0006182 9.6 NPPA NPPB
16 receptor guanylyl cyclase signaling pathway GO:0007168 9.59 NPPA NPPB
17 chylomicron assembly GO:0034378 9.58 APOA1 APOB
18 phospholipid homeostasis GO:0055091 9.57 APOA1 FABP3
19 body fluid secretion GO:0007589 9.55 EDN1 NPPB
20 response to fluid shear stress GO:0034405 9.54 GJA1 NOS3
21 chylomicron remodeling GO:0034371 9.51 APOA1 APOB
22 phosphatidylinositol 3-kinase signaling GO:0014065 9.5 EDN1 IRS1 PIK3C2A
23 negative regulation of hydrolase activity GO:0051346 9.48 APOA1 NOS3
24 lipoprotein biosynthetic process GO:0042158 9.46 APOA1 APOB
25 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.43 EDN1 NOS3
26 triglyceride catabolic process GO:0019433 9.43 APOA1 APOB FABP3
27 regulation of blood pressure GO:0008217 9.35 ACE EDN1 NOS3 NPPA NPPB
28 negative regulation of blood coagulation GO:0030195 9.33 EDN1 KNG1 SERPINE1
29 regulation of blood vessel size GO:0050880 9.02 EDN1 KNG1 NOS3 NPPA NPPB

Molecular functions related to Coronary Artery Anomaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.43 APOA1 APOB PON1
2 hormone activity GO:0005179 9.33 EDN1 NPPA NPPB
3 signaling receptor binding GO:0005102 9.17 EDN1 GJA1 KNG1 NPPA NPPB PLAT
4 hormone receptor binding GO:0051427 8.96 NPPA NPPB

Sources for Coronary Artery Anomaly

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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