MCID: CRN270
MIFTS: 28

Coronary Artery Dissection, Spontaneous

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Coronary Artery Dissection, Spontaneous

MalaCards integrated aliases for Coronary Artery Dissection, Spontaneous:

Name: Coronary Artery Dissection, Spontaneous 58 74
Idiopathic Spontaneous Coronary Artery Dissection 60
Spontaneous Coronary Artery Dissection 54
Idiopathic Scad 60

Characteristics:

Orphanet epidemiological data:

60
idiopathic spontaneous coronary artery dissection
Inheritance: Not applicable; Age of onset: Adult;

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
coronary artery dissection, spontaneous:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 122455
ICD10 via Orphanet 35 I25.4
Orphanet 60 ORPHA458718
MedGen 43 C1852540
SNOMED-CT via HPO 70 263681008
UMLS 74 C1852540

Summaries for Coronary Artery Dissection, Spontaneous

NIH Rare Diseases : 54 Spontaneous coronary artery dissection (SCAD) is a condition in which blood accumulates between the layers of tissue that make up the wall of the coronary artery (the vessel that supplies blood to the heart). The trapped blood then creates a blockage which interferes with blood flow to the heart. Depending on the degree of blockage, symptoms can range from chest pain to heart attack or cardiac arrest. For some, the first symptom is a heart attack. If the blockage is partial, symptoms may include shortness of breath, a rapid heartbeat, sweating, nausea, and fatigue (tiredness). Though SCAD can occur at any age, most cases occur in otherwise healthy people between the ages of 30 and 50. It is more common in women. SCAD is an urgent situation and requires immediate attention. Though the exact cause of SCAD is not fully understood, risk factors include pregnancy, recently giving birth, very high blood pressure, and extreme exercise. Certain conditions such as connective tissue disorders or fibromuscular dysplasia (FMD) may also increase a person�??s risk of developing SCAD. Treatment depends on the signs and severity of the disease but may include allowing the dissection to heal on its own, medications to reduce the risk of clots, or percutaneous coronary intervention. Some cases require surgery. People who have survived SCAD may be at risk for another dissection.  

MalaCards based summary : Coronary Artery Dissection, Spontaneous, also known as idiopathic spontaneous coronary artery dissection, is related to myocardial infarction and acute myocardial infarction. The drugs Ramipril and Calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and ovary, and related phenotypes are abnormality of metabolism/homeostasis and coronary artery dissection

Wikipedia : 77 A spontaneous coronary artery dissection (SCAD) (occasionally coronary artery dissection) is a rare,... more...

Description from OMIM: 122455

Related Diseases for Coronary Artery Dissection, Spontaneous

Diseases related to Coronary Artery Dissection, Spontaneous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 10.7
2 acute myocardial infarction 10.6
3 ischemia 10.5
4 cardiac conduction defect 10.4
5 cardiac arrest 10.3
6 broken heart syndrome 10.3
7 systemic lupus erythematosus 10.2
8 antiphospholipid syndrome 10.2
9 kidney disease 10.2
10 inferior myocardial infarction 10.2
11 lupus erythematosus 10.2
12 polycystic kidney disease 10.2
13 cardiac tamponade 10.2
14 ehlers-danlos syndrome 10.2
15 atrial standstill 1 10.1
16 alport syndrome 10.1
17 loeys-dietz syndrome 10.1
18 coronary artery vasospasm 10.1
19 hypothyroidism 10.1
20 autosomal dominant polycystic kidney disease 10.1
21 depression 10.1
22 syncope 10.1
23 aortic valve disease 1 9.9
24 fibromuscular dysplasia 9.9
25 attention deficit-hyperactivity disorder 9.9
26 marfan syndrome 9.9
27 migraine with or without aura 1 9.9
28 nail-patella syndrome 9.9
29 neurofibromatosis, type iv, of riccardi 9.9
30 polycythemia vera 9.9
31 ventricular fibrillation, paroxysmal familial, 1 9.9
32 anxiety 9.9
33 diabetes mellitus, ketosis-prone 9.9
34 angina pectoris 9.9
35 leukemia 9.9
36 pol iii-related leukodystrophies 9.9
37 polycystic ovary syndrome 9.9
38 atrial fibrillation 9.9
39 thrombosis 9.9
40 mitral valve stenosis 9.9
41 vascular disease 9.9
42 churg-strauss syndrome 9.9
43 lipid metabolism disorder 9.9
44 aortic aneurysm 9.9
45 coronary stenosis 9.9
46 anterolateral myocardial infarction 9.9
47 septal myocardial infarction 9.9
48 polycythemia 9.9
49 vasculitis 9.9
50 bacterial meningitis 9.9

Graphical network of the top 20 diseases related to Coronary Artery Dissection, Spontaneous:



Diseases related to Coronary Artery Dissection, Spontaneous

Symptoms & Phenotypes for Coronary Artery Dissection, Spontaneous

Human phenotypes related to Coronary Artery Dissection, Spontaneous:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 33 HP:0001939
2 coronary artery dissection 33 HP:0006702

Symptoms via clinical synopsis from OMIM:

58
Cardiac:
spontaneous coronary artery dissection

Lab:
cystic medial degeneration of coronary artery with accumulation of glycosaminoglycans

Misc:
striking predilection for women, esp. postpartum

Clinical features from OMIM:

122455

Drugs & Therapeutics for Coronary Artery Dissection, Spontaneous

Drugs for Coronary Artery Dissection, Spontaneous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ramipril Approved Phase 4 87333-19-5 5362129
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Antihypertensive Agents Phase 4
4 Rosuvastatin Calcium Phase 4 147098-20-2
5 Hypolipidemic Agents Phase 4
6 Anticholesteremic Agents Phase 4
7 Antimetabolites Phase 4
8 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
9 Angiotensin-Converting Enzyme Inhibitors Phase 4
10 HIV Protease Inhibitors Phase 4
11
protease inhibitors Phase 4
12 Calcium, Dietary Phase 4
13 Lipid Regulating Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD Recruiting NCT02008786 Phase 4 ramipril;rosuvastatin;placebo
2 Spontaneous Coronary Artery Dissection anaLysIs of the Brazilian Updated Registry Recruiting NCT03398850

Search NIH Clinical Center for Coronary Artery Dissection, Spontaneous

Genetic Tests for Coronary Artery Dissection, Spontaneous

Anatomical Context for Coronary Artery Dissection, Spontaneous

MalaCards organs/tissues related to Coronary Artery Dissection, Spontaneous:

42
Heart, Kidney, Ovary

Publications for Coronary Artery Dissection, Spontaneous

Articles related to Coronary Artery Dissection, Spontaneous:

# Title Authors Year
1
Primary percutaneous coronary intervention in a case of idiopathic spontaneous coronary artery dissection. ( 22477765 )
2012
2
Idiopathic spontaneous coronary artery dissection. Clinical and pathological correlate. ( 18068235 )
2009
3
Idiopathic spontaneous coronary artery dissection: a case report. ( 19012216 )
2008
4
Idiopathic spontaneous coronary artery dissection presenting as acute myocardial infarction in a young boy. ( 19242014 )
2008
5
A rare case of idiopathic spontaneous coronary artery dissection causing acute myocardial infarction. ( 18301155 )
2008
6
Idiopathic spontaneous coronary artery dissection and drug-eluting stents. ( 16236371 )
2006
7
Idiopathic spontaneous coronary artery dissection: incidence, diagnosis and treatment. ( 15907402 )
2005

Variations for Coronary Artery Dissection, Spontaneous

Expression for Coronary Artery Dissection, Spontaneous

Search GEO for disease gene expression data for Coronary Artery Dissection, Spontaneous.

Pathways for Coronary Artery Dissection, Spontaneous

GO Terms for Coronary Artery Dissection, Spontaneous

Sources for Coronary Artery Dissection, Spontaneous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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