MCID: CRN270
MIFTS: 33

Coronary Artery Dissection, Spontaneous

Categories: Blood diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Coronary Artery Dissection, Spontaneous

MalaCards integrated aliases for Coronary Artery Dissection, Spontaneous:

Name: Coronary Artery Dissection, Spontaneous 57 72
Idiopathic Spontaneous Coronary Artery Dissection 59
Spontaneous Coronary Artery Dissection 53
Idiopathic Scad 59

Characteristics:

Orphanet epidemiological data:

59
idiopathic spontaneous coronary artery dissection
Inheritance: Not applicable; Age of onset: Adult;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
coronary artery dissection, spontaneous:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 122455
ICD10 via Orphanet 34 I25.4
Orphanet 59 ORPHA458718
MedGen 42 C1852540
UMLS 72 C1852540

Summaries for Coronary Artery Dissection, Spontaneous

NIH Rare Diseases : 53 Spontaneous coronary artery dissection (SCAD) is a condition in which blood accumulates between the layers of tissue that make up the wall of the coronary artery (the vessel that supplies blood to the heart). The trapped blood then creates a blockage which interferes with blood flow to the heart. Depending on the degree of blockage, symptoms can range from chest pain to heart attack or cardiac arrest. For some, the first symptom is a heart attack. If the blockage is partial, symptoms may include shortness of breath, a rapid heartbeat, sweating, nausea, and fatigue (tiredness). Though SCAD can occur at any age, most cases occur in otherwise healthy people between the ages of 30 and 50. It is more common in women. SCAD is an urgent situation and requires immediate attention. Though the exact cause of SCAD is not fully understood, risk factors include pregnancy, recently giving birth, very high blood pressure, and extreme exercise. Certain conditions such as connective tissue disorders or fibromuscular dysplasia (FMD) may also increase a person's risk of developing SCAD. Treatment depends on the signs and severity of the disease but may include allowing the dissection to heal on its own, medications to reduce the risk of clots, or percutaneous coronary intervention. Some cases require surgery. People who have survived SCAD may be at risk for another dissection.

MalaCards based summary : Coronary Artery Dissection, Spontaneous, also known as idiopathic spontaneous coronary artery dissection, is related to cardiac conduction defect and ischemia. The drugs Ramipril and Calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related phenotypes are abnormality of metabolism/homeostasis and coronary artery dissection

Wikipedia : 75 A spontaneous coronary artery dissection is a rare, sometimes fatal traumatic condition, with eighty... more...

More information from OMIM: 122455

Related Diseases for Coronary Artery Dissection, Spontaneous

Diseases related to Coronary Artery Dissection, Spontaneous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 cardiac conduction defect 10.8
2 ischemia 10.6
3 ventricular fibrillation, paroxysmal familial, 1 10.5
4 fibromuscular dysplasia 10.4
5 connective tissue disease 10.4
6 coronary artery vasospasm 10.4
7 atrial standstill 1 10.3
8 marfan syndrome 10.3
9 broken heart syndrome 10.3
10 systemic lupus erythematosus 10.3
11 cardiac tamponade 10.3
12 coronary artery anomaly 10.3
13 antiphospholipid syndrome 10.3
14 lupus erythematosus 10.3
15 aneurysm 10.3
16 migraine with or without aura 1 10.2
17 hyperlipoproteinemia, type iii 10.2
18 loeys-dietz syndrome 10.2
19 lipid metabolism disorder 10.2
20 coronary stenosis 10.2
21 kidney disease 10.2
22 cocaine abuse 10.2
23 syncope 10.2
24 pre-eclampsia 10.2
25 intermediate coronary syndrome 10.2
26 acute myocardial infarction 10.2
27 atherosclerosis susceptibility 10.1
28 sarcoidosis 1 10.1
29 arterial tortuosity syndrome 10.1
30 netherton syndrome 10.1
31 coronary heart disease 1 10.1
32 thrombosis 10.1
33 alport syndrome 10.1
34 coronary thrombosis 10.1
35 eclampsia 10.1
36 hypothyroidism 10.1
37 vascular disease 10.1
38 cerebrovascular disease 10.1
39 collagen disease 10.1
40 polyarteritis nodosa 10.1
41 coronary artery aneurysm 10.1
42 autoimmune disease 9.9
43 aortic valve disease 1 9.9
44 hashimoto thyroiditis 9.9
45 attention deficit-hyperactivity disorder 9.9
46 hypercholesterolemia, familial, 1 9.9
47 nail-patella syndrome 9.9
48 neurofibromatosis, type iv, of riccardi 9.9
49 pulmonary hypertension, primary, 1 9.9
50 acrocallosal syndrome 9.9

Graphical network of the top 20 diseases related to Coronary Artery Dissection, Spontaneous:



Diseases related to Coronary Artery Dissection, Spontaneous

Symptoms & Phenotypes for Coronary Artery Dissection, Spontaneous

Human phenotypes related to Coronary Artery Dissection, Spontaneous:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 coronary artery dissection 32 HP:0006702

Symptoms via clinical synopsis from OMIM:

57
Cardiac:
spontaneous coronary artery dissection

Lab:
cystic medial degeneration of coronary artery with accumulation of glycosaminoglycans

Misc:
striking predilection for women, esp. postpartum

Clinical features from OMIM:

122455

Drugs & Therapeutics for Coronary Artery Dissection, Spontaneous

Drugs for Coronary Artery Dissection, Spontaneous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ramipril Approved Phase 4 87333-19-5 5362129
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Antihypertensive Agents Phase 4
4 HIV Protease Inhibitors Phase 4
5
protease inhibitors Phase 4
6 Lipid Regulating Agents Phase 4
7 Rosuvastatin Calcium Phase 4 147098-20-2
8 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
9 Angiotensin-Converting Enzyme Inhibitors Phase 4
10 Hypolipidemic Agents Phase 4
11 Calcium, Dietary Phase 4
12 Anticholesteremic Agents Phase 4
13 Antimetabolites Phase 4

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Effects of Statin and Angiotensin-converting Enzyme Inhibitor on Coronary Flow Reserve, indEx of Microcirculatory Resistance, and Symptoms in Patients With Spontaneous Coronary Artery Dissection (SAFER-SCAD) Study Recruiting NCT02008786 Phase 4 ramipril;rosuvastatin;placebo
2 Spontaneous Coronary Artery Dissection anaLysIs of the Brazilian Updated Registry: Epidemiological Data, Clinical Results and Long-Term Follow-up (SCALIBUR Registry). Recruiting NCT03398850
3 Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity Recruiting NCT03941184
4 Spanish Registry on Spontaneous Coronary Artery Dissection Recruiting NCT03607981
5 The "Virtual" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry Recruiting NCT01429727
6 PREVALENCE STUDY OF FIBROMUSCULAR DYSPLASIA IN PATIENTS WITH HAEMATOMA OR SPONTANEOUS CORONARY ARTERY DISSECTION Recruiting NCT02799186
7 Defining the Basis of Fibromuscular Dysplasia: The Define-FMD Study Recruiting NCT01967511
8 Canadian Spontaneous Coronary Artery Dissection (SCAD) Cohort Study Active, not recruiting NCT02188069
9 Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD) Enrolling by invitation NCT01427179
10 Genetics of Spontaneous Coronary Artery Dissection (SCAD-INSPIRE Genetics): A Substudy of the INSPIRE Registry Enrolling by invitation NCT03876847
11 Angiographic and Psychosocial Evaluation of Peripartum vs. Non Peripartum Spontaneous Coronary Artery Dissection (SCAD): A Collaborative Study Enrolling by invitation NCT03390998

Search NIH Clinical Center for Coronary Artery Dissection, Spontaneous

Genetic Tests for Coronary Artery Dissection, Spontaneous

Anatomical Context for Coronary Artery Dissection, Spontaneous

MalaCards organs/tissues related to Coronary Artery Dissection, Spontaneous:

41
Heart, Kidney, Brain, Testes, Endothelial

Publications for Coronary Artery Dissection, Spontaneous

Articles related to Coronary Artery Dissection, Spontaneous:

(show top 50) (show all 960)
# Title Authors PMID Year
1
Clinical course and long-term prognosis of spontaneous coronary artery dissection. 38 8
2773790 1989
2
"Spontaneous" coronary artery dissection. The challenge of detection, the enigma of cause. 38 8
2929545 1989
3
Spontaneous coronary artery dissection: case report and evidence for a defect in collagen metabolism. 38 8
3792352 1986
4
Spontaneous coronary artery dissection during cisplatin and capecitabine therapy. 38
31338186 2019
5
Spontaneous Coronary Artery Dissection in the Postoperative Period: A Case Report. 38
30907753 2019
6
Spontaneous Coronary Artery Dissection and Hypothyroidism. 38
30097393 2019
7
An Unusual Presentation of Postpartum Spontaneous Coronary Artery Dissection. 38
31404313 2019
8
Spontaneous coronary artery dissection: Acute findings on coronary computed tomography angiography. 38
29376398 2019
9
A case of spontaneous coronary artery dissection with early de novo recurrence. 38
31320943 2019
10
Spontaneous coronary artery dissection in a woman undergoing pseudomenopause therapy with leuprorelin: A case report. 38
31320945 2019
11
Patient-Reported Psychological Distress After Spontaneous Coronary Artery Dissection: EVIDENCE FOR POST-TRAUMATIC STRESS. 38
31343583 2019
12
Pathogenic TSR1 Gene Variants in Patients With Spontaneous Coronary Artery Dissection. 38
31296288 2019
13
Spontaneous coronary artery dissection and associated myocardial bridging: Current evidence from cohort study and case reports. 38
31203908 2019
14
Association of TSR1 Variants and Spontaneous Coronary Artery Dissection. 38
31296287 2019
15
Familial Spontaneous Coronary Artery Dissection and the SMAD-3 Mutation. 38
31085000 2019
16
Spontaneous coronary artery dissection: etiology and recurrence. 38
31232618 2019
17
Clinical characteristics of spontaneous coronary artery dissection in young female patients with acute myocardial infarction in Korea. 38
31311261 2019
18
Coronary artery fenestration as rescue management of intramural haematoma with luminal compression. 38
30838754 2019
19
Coronary artery tortuosity: a narrative review. 38
31211725 2019
20
Screening of extra-coronary arteriopathy with magnetic resonance angiography in patients with spontaneous coronary artery dissection: a single-centre experience. 38
31275813 2019
21
Left main and triple vessel dissection 2 months postpartum. 38
30659733 2019
22
Sutureless repair of spontaneous coronary dissection with free wall rupture and cardiac tamponade. 38
30690851 2019
23
Prevalence of Coronary Vasospasm Using Coronary Reactivity Testing in Patients With Spontaneous Coronary Artery Dissection. 38
30948002 2019
24
Recurrent idiopathic spontaneous coronary artery dissection. 38
31266572 2019
25
Spontaneous Healing in Spontaneous Coronary Artery Dissection: An Angiographic Paradox? 38
31171284 2019
26
Current state-of-play in spontaneous coronary artery dissection. 38
31275818 2019
27
Spontaneous coronary artery dissection: Not so infrequent to be ignored. 38
31230806 2019
28
Risk Factors, Imaging Findings, and Sex Differences in Spontaneous Coronary Artery Dissection. 38
30929769 2019
29
Reply: Spontaneous Healing in Spontaneous Coronary Artery Dissection: An Angiographic Paradox? 38
31171285 2019
30
Spontaneous coronary artery dissection in systemic lupus erythematosus: case-based review. 38
31227856 2019
31
Slit in the Coronaries: A Case of Spontaneous Coronary Artery Dissection. 38
31410324 2019
32
Isolated septal branch lesion as the only diagnostic clue for spontaneous coronary artery dissection. 38
31233401 2019
33
Characteristics and Clinical Outcomes of Patients With Spontaneous Coronary Artery Dissection. 38
31084345 2019
34
Spontaneous Coronary Artery Dissection in a 26-Year-Old-Male Soldier. 38
30215793 2019
35
Recurrent Spontaneous Coronary Artery Dissection Presenting with STEMI, Once is Never Enough! 38
31092182 2019
36
The Evidence on Estrogen, Progesterone, and Spontaneous Coronary Artery Dissection. 38
30969320 2019
37
Spontaneous coronary artery dissection in cardiac sarcoidosis. 38
31198569 2019
38
Spontaneous coronary artery dissection in a pregnant woman associated with fetal complication: A case report and review of literature. 38
31196795 2019
39
Lesion characteristics and prognosis of acute coronary syndrome without angiographically significant coronary artery stenosis. 38
31056642 2019
40
Spontaneous coronary artery dissections and associated predisposing factors: a narrative review. 38
30684142 2019
41
Emerging misunderstood presentations of cardiovascular disease in young women. 38
30793342 2019
42
Spontaneous Coronary Artery Dissection in a Postpartum Female: Case Report and Simplified Algorithm for its Diagnosis and Management. 38
31223547 2019
43
Spontaneous coronary artery dissection and its association with takotsubo syndrome: Novel insights from a tertiary center registry. 38
31037831 2019
44
Sudden cardiac death in a young adult man due to spontaneous coronary artery dissection. 38
31025638 2019
45
Spontaneous coronary artery dissection: no longer a rare disease. 38
30844061 2019
46
Spontaneous Coronary Artery Dissection - Case Report and Literature Review. 38
30994727 2019
47
Spontaneous coronary artery dissection: An often unrecognized cause of acute coronary syndrome. 38
30951451 2019
48
Spontaneous coronary artery dissection: a review of complications and management strategies. 38
30957570 2019
49
Rare Missense Variants in TLN1 Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection. 38
30888838 2019
50
Percutaneous Coronary Intervention for the Treatment of Spontaneous Coronary Artery Dissection. 38
30832942 2019

Variations for Coronary Artery Dissection, Spontaneous

Expression for Coronary Artery Dissection, Spontaneous

Search GEO for disease gene expression data for Coronary Artery Dissection, Spontaneous.

Pathways for Coronary Artery Dissection, Spontaneous

GO Terms for Coronary Artery Dissection, Spontaneous

Sources for Coronary Artery Dissection, Spontaneous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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