MCID: CRN019
MIFTS: 48

Coronary Artery Vasospasm

Categories: Cardiovascular diseases

Aliases & Classifications for Coronary Artery Vasospasm

MalaCards integrated aliases for Coronary Artery Vasospasm:

Name: Coronary Artery Vasospasm 12 15 72
Coronary Vasospasm 12 55 44 17
Coronary Artery Spasm 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:11840
MeSH 44 D003329
NCIt 50 C34515
SNOMED-CT 68 23687008
UMLS 72 C0010073

Summaries for Coronary Artery Vasospasm

MalaCards based summary : Coronary Artery Vasospasm, also known as coronary vasospasm, is related to angina pectoris and raynaud phenomenon, and has symptoms including angina pectoris An important gene associated with Coronary Artery Vasospasm is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Hydrochlorothiazide and Losartan have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are Decreased substrate adherent cell growth and cardiovascular system

Wikipedia : 75 Coronary vasospasm is a sudden, intense vasoconstriction of an epicardial coronary artery that causes... more...

Related Diseases for Coronary Artery Vasospasm

Diseases related to Coronary Artery Vasospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 angina pectoris 33.9 PIK3C2A NOS3 EDN1
2 raynaud phenomenon 30.5 HTR2A EDN1 ADRA2C
3 pulmonary edema 30.4 PIK3C2A NOS3 EDN1
4 coronary artery anomaly 30.0 PIK3C2A NOS3 EDN1 ADRB1
5 acute myocardial infarction 30.0 PIK3C2A EDN1 ADRB1
6 heart disease 29.8 PIK3C2A NOS3 EDN1 ADRB1
7 attention deficit-hyperactivity disorder 29.4 HTR2A ADRA2C ADRA2A ADRA1A
8 orthostatic intolerance 29.0 NOS3 EDN1 ADRB1 ADRA2C ADRA2B ADRA2A
9 myocardial infarction 28.8 PIK3C2A NOS3 EDN1 ADRB1 ADRA2B
10 dilated cardiomyopathy 28.7 NOS3 EDN1 ADRB1 ADRA2C
11 hypertension, essential 27.5 NOS3 EDN1 ADRB3 ADRB1 ADRA2B ADRA1D
12 chronic mountain sickness 10.5 NOS3 EDN1
13 atrioventricular block 10.5
14 brachydactyly, type e2 10.5 NOS3 EDN1
15 acute chest syndrome 10.5 NOS3 EDN1
16 buerger disease 10.5 NOS3 HTR2A
17 coronary thrombosis 10.5
18 hyperlipoproteinemia, type iii 10.4
19 persistent fetal circulation syndrome 10.4 NOS3 EDN1
20 priapism 10.4 NOS3 ADRA1A
21 hepatic vascular disease 10.4 NOS3 EDN1
22 sexual disorder 10.4 NOS3 EDN1
23 inferior myocardial infarction 10.3
24 renovascular hypertension 10.3 NOS3 EDN1
25 ventricular fibrillation, paroxysmal familial, 1 10.3
26 sleep apnea 10.3 NOS3 HTR2A EDN1
27 toxic myocarditis 10.3 PIK3C2A NOS3
28 apnea, obstructive sleep 10.3 HTR2A EDN1
29 ischemia 10.3
30 atrial fibrillation 10.3
31 horner's syndrome 10.3 ADRA2A ADRA1A
32 arteries, anomalies of 10.2
33 graves disease 1 10.2
34 cardiac arrest 10.2
35 coronary stenosis 10.2
36 intermediate coronary syndrome 10.2
37 hypereosinophilic syndrome 10.2
38 eosinophilic granulomatosis with polyangiitis 10.2
39 colorectal cancer 10.2
40 migraine with or without aura 1 10.2
41 thrombosis 10.2
42 mitral valve insufficiency 10.2
43 allergic hypersensitivity disease 10.2
44 graves' disease 10.2
45 urticaria 10.2
46 vascular disease 10.2
47 aortic valve insufficiency 10.2
48 47,xyy 10.2
49 hepatopulmonary syndrome 10.1 NOS3 EDN1
50 atherosclerosis susceptibility 10.1

Graphical network of the top 20 diseases related to Coronary Artery Vasospasm:



Diseases related to Coronary Artery Vasospasm

Symptoms & Phenotypes for Coronary Artery Vasospasm

UMLS symptoms related to Coronary Artery Vasospasm:


angina pectoris

GenomeRNAi Phenotypes related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.8 ADRA1A ADRA1D ADRA2B

MGI Mouse Phenotypes related to Coronary Artery Vasospasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C ADRB1
2 behavior/neurological MP:0005386 9.92 ADRA1A ADRA1D ADRA2A ADRA2B ADRA2C ADRB3
3 homeostasis/metabolism MP:0005376 9.85 ADRA1A ADRA2A ADRA2B ADRA2C ADRB1 ADRB3
4 mortality/aging MP:0010768 9.61 ADRA1A ADRA2A ADRA2B ADRA2C ADRB1 EDN1
5 muscle MP:0005369 9.17 ADRA1A ADRA1D ADRA2B ADRB1 EDN1 HTR2A

Drugs & Therapeutics for Coronary Artery Vasospasm

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Nitroglycerin Nitroglycerin is indicated for various purposes.[L4894] It is indicated to prevent and treat angina or chest pain due to cardiovascular disease, as well as to treat peri-operative hypertension or induce intra-operative hypotension.[L4429,L7099] It is also indicated to treat acute heart failure in patients with myocardial infarction.[L7099] In the ointment form, nitroglycerin is indicated to treat pain caused by anal fissures.[L7096] The transdermal form is applied directly to the skin to prevent acute anginal attacks.[L7141] The intravenous form is used off-label in emergency settings and is commonly used to treat acute coronary spasm caused by cocaine, hypertensive emergencies, as well as acute congestive heart failure exacerbations.[T628] Some other off-label uses of nitroglycerin include management of variceal hemorrhage[A180280], management of esophageal spasticity[A180283], and induction of uterine relaxation.[A180277] DB00727

Drugs for Coronary Artery Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
2
Losartan Approved Phase 4 114798-26-4 3961
3
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
4
Doxazosin Approved Phase 4 74191-85-8 3157
5
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
6
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
7
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
8
Ramipril Approved Phase 4 87333-19-5 5362129
9
Simvastatin Approved Phase 4 79902-63-9 54454
10
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
11
Amlodipine Approved Phase 4 88150-42-9 2162
12
Atorvastatin Approved Phase 4 134523-00-5 60823
13
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
14
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
15
Rilmenidine Approved, Investigational Phase 4 54187-04-1
16
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
17
Prazosin Approved Phase 4 19216-56-9 4893
18
Bisoprolol Approved Phase 4 66722-44-9 2405
19
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
20
Indapamide Approved Phase 4 26807-65-8 3702
21
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
22
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
23
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
24
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
25
Sarpogrelate Investigational Phase 4 125926-17-2 5160
26 Tocotrienol Investigational Phase 4 6829-55-6
27 Angiotensin Receptor Antagonists Phase 4
28 Angiotensinogen Phase 4
29 Angiotensin II Type 1 Receptor Blockers Phase 4
30 Giapreza Phase 4
31 Anti-Arrhythmia Agents Phase 4
32 Adrenergic alpha-Antagonists Phase 4
33 Adrenergic alpha-1 Receptor Antagonists Phase 4
34 Natriuretic Agents Phase 4
35 Mineralocorticoid Receptor Antagonists Phase 4
36 Mineralocorticoids Phase 4
37 diuretics Phase 4
38 Diuretics, Potassium Sparing Phase 4
39 Hormone Antagonists Phase 4
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
41 Adrenergic Agonists Phase 4
42 Adrenergic beta-Agonists Phase 4
43 Adrenergic Agents Phase 4
44 Adrenergic beta-Antagonists Phase 4
45 Angiotensin-Converting Enzyme Inhibitors Phase 4
46 Peripheral Nervous System Agents Phase 4
47 HIV Protease Inhibitors Phase 4
48
protease inhibitors Phase 4
49 Adrenergic Antagonists Phase 4
50 Autonomic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension Unknown status NCT00994617 Phase 4 Losartan and hydrochlorothiazide;Hydrochlorothiazide switched over with Losartan at 8 weeks
2 Optimum Treatment for Drug-Resistant Hypertension Unknown status NCT02369081 Phase 4 Spironolactone;Bisoprolol;Doxazosin;Placebo
3 Prevalence and Treatment of Resistant Hypertension in Diabetic Patients in Yaounde Completed NCT02426099 Phase 4 Low dose spironolactone
4 The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm Completed NCT03930433 Phase 4 Nebivolol;Diltiazem;Nebivolol+Diltiazem
5 Renal Denervation in Patients With Resistant Hypertension Completed NCT01570777 Phase 4
6 Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT) Completed NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
7 A Prospective, Single-center, Randomized Study to Evaluate the Effect of Sarpogrelate, a Selective Serotonin Receptor Antagonist, and High Dose Statin on the Reduction of Coronary Spasm in the Patients With Variant Angina Recruiting NCT01674686 Phase 4 Sarpogrelate;Atorvastatin
8 Effects of Long-term Vitamin C+E and Statin Therapy on Vasospasm Improvement and Regression of Atheroma in Patients With Variant Angina Recruiting NCT03228238 Phase 4 Vitamin C and Vitamin E;Statin;Standard medication for variant angina
9 Calcium Administration in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass (ICARUS Trial): Prospective Randomized, Double-blind Placebo-controlled Superiority Trial Recruiting NCT03772990 Phase 4 Calcium Chloride;0.9% Sodium Chloride
10 Optimum and Stepped Care Standardised Antihypertensive Treatment With or Without Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis. ANDORRA TRIAL Terminated NCT02539810 Phase 4 Anti hypertensive, statin and antiplatelet medication.
11 Clinical Evaluation of the Therapeutic Intra-Vascular Ultrasound (TIVUS™) System for Renal Denervation in Patients With Resistant Hypertension Unknown status NCT01835535 Phase 2, Phase 3
12 South Danish Hypertension and Diabetes Study Completed NCT01062763 Phase 3 spironolactone;placebo
13 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans AIM III Completed NCT01067339 Phase 3 darapladib;placebo
14 Application of Sildenafil in Patients With Documented Coronary Vasospasm to Explore the Pathophysiology of Coronary Vasospasm and the Therapeutic Effect of Sildenafil in Patients Suffering From Coronary Vasospasm Withdrawn NCT00454714 Phase 3 single dose Sildenafil;Single dose placebo
15 Toxicity OF Fluoropyrimidines: A Comparative Study of the Cardiotoxicity of capEcitabine and tEysuno Unknown status NCT01845337 Phase 2 Teysuno;Capecitabine
16 Phase II Randomized, Double-Blind, Placebo-Controlled Trial of Homeopathy in Resistant Arterial Hypertension Completed NCT02124473 Phase 2
17 The Role of Renal Denervation in Improving Outcomes of Catheter Ablation in Patients With Refractory Symptomatic Atrial Fibrillation and Resistant Hypertension Completed NCT01117025 Phase 2
18 Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography Active, not recruiting NCT01673516 Phase 2
19 Feasibility Study of Perivascular Computer Tomography-guided Ethanol Sympatholysis for the Treatment of Therapy-resistant Arterial Hypertension Terminated NCT02653222 Phase 2
20 Efficacy and Safety of Low Intensity- Extracorporeal Shockwave Therapy in Drug Resistant Hypertension Unknown status NCT02042066 Phase 1
21 The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors in Resistant Hypertension Unknown status NCT02623036 Phase 1 Equivalent dose enalapril;Equivalent dose lisinopril
22 Assessment of Coronary Plaque Composition Using Near Infrared Spectroscopy During Inhibition of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity Completed NCT01581632 Phase 1
23 Effects of Training in a Heated Pool in Patients With Refractory Hypertension Unknown status NCT01863082
24 Clinical Observation of CHD Phlegm and Blood-stasis Syndrome Patients Unknown status NCT02967718
25 A Study on Medication Adherence and "True" Resistance in Patients Referred to a Medical Outpatient Department in Germany With the Diagnosis "Resistant Hypertension". Unknown status NCT02128386
26 Panic Disorder and Cardiac Risk: Evaluation of a Psychological Treatment Which Addresses Biology, Psychology and Behaviour Unknown status NCT00168506 SSRI;CBT;CBT/SSRI
27 Carotid Baroreflex Activation and Its Effect on the Chemoreflex Study Unknown status NCT02210923
28 A Prospective, Post-marketing, Single-arm, Open Label, Multi-center Clinical Study to Evaluate the Safety and Efficacy of the ReDy™ Renal Denervation System in the Treatment of Patients With Uncontrolled Hypertension Unknown status NCT02690909
29 Effect of the Continuous Positive Airway Pressure on Blood Pressure and Arterial Stiffness in Obstructive Sleep Apnea Patients With Resistant Hypertension Unknown status NCT02385864
30 Correlation Between Abnormal Coronary Vasoreactivity Testing, Expansion of CD4+CD28null T Cells and Biomarkers for Inflammation and Endothelial Dysfunction in Patients With Angina Despite Angiographically Normal Coronary Arteries. Unknown status NCT01162824 Acetylcholine;Adenosine
31 Health Coaching Based Treatment Versus Usual Treatment of Systemic Arterial Hypertension and Comorbidities Unknown status NCT03046680
32 The Use of Cardiovascular Biomarkers in Abdominal Aortic Surgery: Possibility of Risk Assessment and Stratification Unknown status NCT02122497
33 The Prevalence and the Prognosis of Resistant Hypertension Ascertained With Systemic Investigation and Optimal Treatment With Antihypertensive Drugs Unknown status NCT01703780
34 Digital Tonometry for Measurement of Peripheral Artery Reactive Hyperemia as Non-invasive Test for Diagnosis of Coronary Artery Spasm Completed NCT00619294
35 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level in Hypertensive Patients Treated With Blood Pressure Lowering Drugs Completed NCT01882790
36 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level Completed NCT01877993
37 The Multicenter Registry to Evaluate the Natural Course of Coronary Spasm Patients Presenting Aborted Sudden Cardiac Death Completed NCT02298543
38 Prevalence of Primary Aldosteronism and Status of Renin-Angiotensin System in Resistant Hypertension:An Observational Study in China Completed NCT01459042
39 Clinical Evaluation of Safety and Performance of the BackBeat Moderato System Completed NCT02282033
40 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans Completed NCT01557088
41 Reintervention After Previous Renal Denervation in Non-responding Patients With Severe Hypertension Completed NCT01834118
42 Circadian Autonomic Disturbances in Resistant Hypertension With and Without White-coat Phenomenon Completed NCT01833429
43 "Reversibility of Cardiovascular Injury With Continuous Positive Airway Pressure (CPAP) Use: Mechanisms Involved" Completed NCT01317329
44 Influence of Plasma Glucose Levels on Retinal Vascular Diameter and Choroidal Blood Flow in Vasospastic Subjects Completed NCT00350129
45 Rapid Renal Sympathetic Denervation for Resistant Hypertension Using the OneShot™ Ablation System Completed NCT01520506
46 The Clinical Efficacy Comparison of Two Renal Sympathetic Denervation Strategies ---- Full Length Versus Proximal Renal Arteries Ablation Completed NCT01848275
47 Observational Study of the Polymorphisms of the Renin-angiotensin-aldosterone System and Their Relation to Resistant Systemic Arterial Hypertension and Adverse Cardiovascular Events Completed NCT01173029 Anti-hypertensive drug treatment
48 Renal Sympathetic Denervation for Treatment Resistant Hypertension and Potential Effects on Glucose Metabolism and Cardiovascular Risk-Factors (The Re-Shape CV-Risk Study) Completed NCT01630928
49 Anatomically Optimized Distal Renal Denervation for Treatment of Resistant Hypertension Completed NCT02667912
50 Causal Inference Research of Resistant Hypertension Treatment With Recipe of Removing Both Phlegm and Blood Stasis in a Real World Study Completed NCT01904695 Early Phase 1 Herbs;Antihypertensive drugs

Search NIH Clinical Center for Coronary Artery Vasospasm

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Nitroglycerin

Cochrane evidence based reviews: coronary vasospasm

Genetic Tests for Coronary Artery Vasospasm

Genetic tests related to Coronary Artery Vasospasm:

# Genetic test Affiliating Genes
1 Coronary Artery Spasm 29

Anatomical Context for Coronary Artery Vasospasm

MalaCards organs/tissues related to Coronary Artery Vasospasm:

41
Heart, Testes, Endothelial, Smooth Muscle, Bone, T Cells, Monocytes

Publications for Coronary Artery Vasospasm

Articles related to Coronary Artery Vasospasm:

(show top 50) (show all 1272)
# Title Authors PMID Year
1
Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction. 9 38
19623039 2009
2
Association of endothelin-1 gene polymorphisms with variant angina in Korean patients. 9 38
19012521 2008
3
Update on evidence for a genetic predisposition to cerebral vasospasm. 9 38
17029342 2006
4
Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. 9 38
16820593 2006
5
Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene. 9 38
16565556 2006
6
Genetic variations in vascular endothelial growth factor and endothelial nitric oxide synthase and their contributions to human disease. 9 38
15825252 2005
7
[Cardioprotective effects of diltiazem infusion in the perioperative period in patients undergoing coronary artery bypass grafting with extracorporeal circulation]. 9 38
14521738 2003
8
Interplanetary travel and permanent injury to normal heart. 9 38
11543600 1997
9
5-HT receptors mediating contractions of the isolated human coronary artery. 9 38
7693489 1993
10
Non-ST-Elevation Myocardial Infarction-Like Syndrome in Scombroid Tuna Fish Poisoning. 38
31221463 2019
11
An unusual complication during alcohol septal ablation: severe left anterior descending artery vasospasm causing cardiac arrest: a case report and review of the literature. 38
31425578 2019
12
Acute ST-Segment Elevation Myocardial Infarction Following Intramuscular Diclofenac: A Case of Kounis Syndrome. 38
31014971 2019
13
Phentermine and Coronary Vasospasm-Induced Myocardial Infarction. 38
31272579 2019
14
Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease? 38
30227459 2019
15
Kounis Syndrome—not a Single-organ Arterial Disorder but a Multisystem and Multidisciplinary Disease 38
31198019 2019
16
ST elevation in recovery post exercise with normal coronary arteries. 38
31289167 2019
17
The novel inodilator ORM-3819 relaxes isolated porcine coronary arteries: role of voltage-gated potassium channels activation. 38
31356552 2019
18
Coronary Vasospasm Induced by Phentermine. 38
31272562 2019
19
Spontaneous coronary vasospasm due to polytrauma. 38
31049387 2019
20
Phase I/II study of everolimus combined with mFOLFOX-6 and bevacizumab for first-line treatment of metastatic colorectal cancer. 38
30302599 2019
21
Prevalence of Coronary Vasospasm Using Coronary Reactivity Testing in Patients With Spontaneous Coronary Artery Dissection. 38
30948002 2019
22
Vancomycin-induced Kounis Syndrome. 38
31182359 2019
23
Myocardial infarction with non-obstructive coronary arteries: a focus on vasospastic angina. 38
30689112 2019
24
Coronary Artery Vasospasm Induced by 5-fluorouracil: Proposed Mechanisms, Existing Management Options and Future Directions. 38
31178935 2019
25
Ventricular fibrillation in a patient with Wolff-Parkinson-White syndrome unrelated to pre-excited atrial fibrillation. 38
31141244 2019
26
Reversible Cerebral Vasoconstriction Syndrome Associated with Coronary Artery Vasospasm. 38
31236082 2019
27
A Curious Case of Coronary Vasospasm with Cardiogenic Shock: Type 1 Kounis Syndrome Complicated by Eosinophilic Myocarditis. 38
31259131 2019
28
Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry). 38
31185091 2019
29
Coronary Artery Spasm, Coronary Reactivity, and Their Psychological Context. 38
30747790 2019
30
Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5-FU or Capecitabine. 38
30396850 2019
31
Reversed redistribution in SPECT images from spontaneous coronary vasospasm. 38
29492837 2019
32
Acute coronary stent thrombosis: A case of type 3 Kounis syndrome. 38
30693057 2019
33
Unexpected, But Reasonable Association Between Anderson-Fabry Disease and Coronary Vasospasm. 38
30606944 2019
34
Vasospastic angina: A literature review of current evidence. 38
30197243 2019
35
Accelerated Idioventricular Rhythm at the Termination of an Episode of Vasospastic Angina. 38
30937229 2019
36
A Rare Case of Cardiogenic Shock Following Severe Multivessel Coronary Vasospasm. 38
31210767 2019
37
Ventricular Fibrillation Induced by Coronary Vasospasm in a Patient with Early Repolarization and Hyperthyroidism. 38
30101915 2018
38
Coronary Vasospasm Following Heart Transplantation: Rapid Progression to Aggressive Cardiac Allograft Vasculopathy. 38
30527163 2018
39
Marijuana-associated ST-elevation myocardial infarction: is this a benign drug. 38
30567245 2018
40
New onset acute pulmonary edema after methylergonovine given during cesarean delivery of a patient with undiagnosed Raynaud's disease. 38
30392649 2018
41
Multi-vessel Coronary Vasospasm after Beta-blocker Administration. 38
29877293 2018
42
5-Fluorouracil-Associated Coronary Vasospasm in a Patient With Metastatic Adenocarcinoma of the Esophagus. 38
31206361 2018
43
Efficacy of Corticosteroid Treatment for Refractory Multivessel Vasospastic Coronary Angina with Hypereosinophilia. 38
29877265 2018
44
Ergonovine Stress Echocardiography for the Diagnosis of Vasospastic Angina and Its Prognostic Implications in 3,094 Consecutive Patients. 38
30238707 2018
45
Identification of Coronary Vasospasm as a Cause of Recurrent Acute Coronary Syndrome. 38
30279296 2018
46
Coronary artery vasospasm in a patient with Churg-Strauss syndrome. 38
30366890 2018
47
Coronary Vasospasm After Burn Injury: First Described Case Series of a Lethal Lesion. 38
29931178 2018
48
Outcomes of beta blocker use in cocaine-associated chest pain: a meta-analysis. 38
29921621 2018
49
Coronary Artery Vasospasm. 38
30146803 2018
50
Reversible myocardial perfusion defects in patients not suffering from obstructive epicardial coronary artery disease as assessed by coronary angiography. 38
27007665 2018

Variations for Coronary Artery Vasospasm

Expression for Coronary Artery Vasospasm

Search GEO for disease gene expression data for Coronary Artery Vasospasm.

Pathways for Coronary Artery Vasospasm

Pathways related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 NOS3 HTR2A EDN1 ADRB3 ADRB1 ADRA2C
2
Show member pathways
13.34 HTR2A EDN1 ADRB3 ADRB1 ADRA2C ADRA2B
3
Show member pathways
13.31 NOS3 ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A
4
Show member pathways
12.63 EDN1 ADRB1 ADRA2B ADRA2A ADRA1A
5
Show member pathways
12.32 NOS3 ADRB3 ADRB1 ADRA1D ADRA1A
6
Show member pathways
12.03 NOS3 HTR2A ADRB3 ADRB1 ADRA1D ADRA1A
7
Show member pathways
12 ADRB3 ADRB1 ADRA1D ADRA1A
8
Show member pathways
11.87 NOS3 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1A
9
Show member pathways
11.7 ADRA2C ADRA2B ADRA2A
10 11.42 KCNJ8 ADRB1 ADRA2A ADRA1D
11
Show member pathways
11.27 HTR2A ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A
12
Show member pathways
11.19 ADRA2C ADRA2A
13 11.19 ADRB1 ADRA2B ADRA2A ADRA1A
14 11.15 NOS3 EDN1 ADRB1 ADRA1A
15 11.12 EDN1 ADRB1
16 10.79 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1A

GO Terms for Coronary Artery Vasospasm

Cellular components related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 PIK3C2A NOS3 KCNJ8 HTR2A ADRB3 ADRB1
2 caveola GO:0005901 9.43 NOS3 HTR2A ADRA1A
3 integral component of postsynaptic membrane GO:0099055 9.33 HTR2A ADRA2C ADRA1A
4 integral component of plasma membrane GO:0005887 9.23 HTR2A ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A
5 membrane GO:0016020 10.06 PIK3C2A NOS3 KCNJ8 HTR2A ADRB3 ADRB1

Biological processes related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 HTR2A EDN1 ADRA2A ADRA1D
2 G protein-coupled receptor signaling pathway GO:0007186 9.97 HTR2A EDN1 ADRB3 ADRB1 ADRA2C ADRA2B
3 cell-cell signaling GO:0007267 9.88 EDN1 ADRA2C ADRA2B ADRA1D ADRA1A
4 response to lipopolysaccharide GO:0032496 9.83 NOS3 KCNJ8 EDN1
5 positive regulation of MAPK cascade GO:0043410 9.83 ADRB3 ADRA2C ADRA2B ADRA2A ADRA1A
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.82 HTR2A EDN1 ADRA1A
7 platelet activation GO:0030168 9.79 ADRA2C ADRA2B ADRA2A
8 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.79 ADRB3 ADRB1 ADRA2A
9 positive regulation of MAP kinase activity GO:0043406 9.76 HTR2A EDN1 ADRA2A
10 activation of protein kinase B activity GO:0032148 9.73 ADRA2C ADRA2B ADRA2A
11 phosphatidylinositol 3-kinase signaling GO:0014065 9.72 PIK3C2A HTR2A EDN1
12 positive regulation of vasoconstriction GO:0045907 9.71 HTR2A ADRA2C ADRA1A
13 regulation of smooth muscle contraction GO:0006940 9.67 ADRA2C ADRA2B ADRA2A
14 regulation of sensory perception of pain GO:0051930 9.66 EDN1 ADRA2C
15 activation of adenylate cyclase activity GO:0007190 9.66 ADRB3 ADRB1
16 activation of phospholipase C activity GO:0007202 9.65 HTR2A ADRA1A
17 positive regulation of cardiac muscle hypertrophy GO:0010613 9.65 EDN1 ADRA1A
18 regulation of vasoconstriction GO:0019229 9.65 EDN1 ADRA2C ADRA2B ADRA2A ADRA1A
19 positive regulation of heart rate GO:0010460 9.64 EDN1 ADRA1A
20 positive regulation of smooth muscle contraction GO:0045987 9.63 EDN1 ADRA1A
21 regulation of blood vessel size GO:0050880 9.63 NOS3 EDN1
22 negative regulation of norepinephrine secretion GO:0010700 9.63 ADRA2C ADRA2B ADRA2A
23 negative regulation of calcium ion transport GO:0051926 9.62 NOS3 ADRA2A
24 negative regulation of potassium ion transport GO:0043267 9.61 NOS3 HTR2A
25 artery smooth muscle contraction GO:0014824 9.6 HTR2A EDN1
26 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.59 NOS3 EDN1
27 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.58 ADRB3 ADRB1
28 receptor transactivation GO:0035624 9.58 ADRA2C ADRA2B ADRA2A
29 adrenergic receptor signaling pathway GO:0071875 9.55 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1A
30 negative regulation of epinephrine secretion GO:0032811 9.54 ADRA2C ADRA2B ADRA2A
31 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 9.52 ADRB1 ADRA1A
32 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.51 ADRB1 ADRA1A
33 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.5 ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D
34 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.17 ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D
35 signal transduction GO:0007165 10.17 HTR2A ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A

Molecular functions related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.88 HTR2A ADRB3 ADRB1 ADRA2B ADRA2A ADRA1A
2 protein heterodimerization activity GO:0046982 9.76 ADRB1 ADRA2C ADRA2A ADRA1A
3 alpha-2A adrenergic receptor binding GO:0031694 9.43 ADRB1 ADRA2C
4 norepinephrine binding GO:0051380 9.43 ADRB3 ADRB1 ADRA2A
5 alpha1-adrenergic receptor activity GO:0004937 9.37 ADRA1D ADRA1A
6 epinephrine binding GO:0051379 9.35 ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A
7 alpha2-adrenergic receptor activity GO:0004938 9.33 ADRA2C ADRA2B ADRA2A
8 beta-adrenergic receptor activity GO:0004939 9.32 ADRB3 ADRB1
9 adrenergic receptor activity GO:0004935 9.17 ADRB3 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1D

Sources for Coronary Artery Vasospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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