MCID: CRN019
MIFTS: 47

Coronary Artery Vasospasm

Categories: Cardiovascular diseases

Aliases & Classifications for Coronary Artery Vasospasm

MalaCards integrated aliases for Coronary Artery Vasospasm:

Name: Coronary Artery Vasospasm 12 15 70
Coronary Vasospasm 12 54 44 17
Coronary Artery Spasm 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:11840
MeSH 44 D003329
NCIt 50 C34515
SNOMED-CT 67 23687008
UMLS 70 C0010073

Summaries for Coronary Artery Vasospasm

MalaCards based summary : Coronary Artery Vasospasm, also known as coronary vasospasm, is related to angina pectoris and inferior myocardial infarction, and has symptoms including angina pectoris An important gene associated with Coronary Artery Vasospasm is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are fMLP Pathway and Pathways in cancer. The drugs Diltiazem and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and smooth muscle, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 73 Coronary vasospasm refers to when a coronary artery suddenly undergoes either complete or sub-total... more...

Related Diseases for Coronary Artery Vasospasm

Diseases related to Coronary Artery Vasospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
# Related Disease Score Top Affiliating Genes
1 angina pectoris 32.0 TNNI3 PIK3C2A NOS3 KNG1 EDN1 CRP
2 inferior myocardial infarction 30.8 TNNI3 PIK3C2A ACE
3 orthostatic intolerance 30.8 REN NOS3 EDN1 ACE
4 pericarditis 30.7 TNNI3 CRP ACE
5 acute myocarditis 30.6 TNNI3 CRP ACE
6 anteroseptal myocardial infarction 30.4 PIK3C2A ACE
7 exanthem 30.4 PIK3C2A CRP ACE
8 silent myocardial infarction 30.4 TNNI3 CRP ACE
9 ischemia 30.3 PIK3C2A NOS3 KNG1 EDN1 ACE
10 coronary stenosis 30.3 TNNI3 PIK3C2A CRP ACE
11 aortic valve insufficiency 30.3 TNNI3 REN CRP ACE
12 lateral myocardial infarction 30.3 TNNI3 PIK3C2A ACE
13 acute myocardial infarction 30.2 TNNI3 PIK3C2A EDN1 CRP ACE
14 atrioventricular block 30.2 TNNI3 PIK3C2A ACE
15 atherosclerosis susceptibility 30.2 NOS3 EDN1 CRP ACE
16 myocardial stunning 30.1 TNNI3 KNG1 EDN1 AHSP ACE
17 limb ischemia 30.1 TNNI3 NOS3 EDN1 ACE
18 peripheral vascular disease 30.1 KNG1 HTR2A CRP ACE
19 eclampsia 30.0 REN NOS3 EDN1 ACE
20 intermediate coronary syndrome 30.0 TNNI3 REN PIK3C2A CRP ACE
21 pulmonary embolism 30.0 TNNI3 CRP ACE
22 arteriosclerosis 30.0 RHOA NOS3 EDN1 CRP ACE
23 mitral valve stenosis 30.0 REN EDN1 CRP ACE
24 substance abuse 29.9 HTR2A CRP ACE
25 fabry disease 29.9 TNNI3 NOS3 CRP
26 left bundle branch hemiblock 29.8 TNNI3 REN PIK3C2A CRP ACE
27 stroke, ischemic 29.8 REN NOS3 CRP AOC3 ACE
28 mitral valve disease 29.8 TNNI3 REN NOS3 CRP ACE
29 constrictive pericarditis 29.8 TNNI3 REN CRP ACE
30 diabetes mellitus, ketosis-prone 29.8 PIK3C2A KCNJ11 ABCC8
31 mitral valve insufficiency 29.7 TNNI3 REN PIK3C2A CRP CMA1 ACE
32 migraine with or without aura 1 29.7 REN NOS3 KNG1 HTR2A EDN1 CRP
33 cardiac arrest 29.7 TNNI3 REN PIK3C2A KCNJ8 ACE
34 atrial heart septal defect 29.6 TNNI3 EDN1 CRP ACE ABCC8
35 pheochromocytoma 29.6 REN KNG1 EDN1 CRP ACE
36 arteries, anomalies of 29.6 TNNI3 REN NOS3 EDN1 CRP ACE
37 pulmonary edema 29.4 TNNI3 REN PIK3C2A NOS3 KNG1 EDN1
38 hypertrophic cardiomyopathy 29.3 TNNI3 RHOA REN PIK3C2A NOS3 KCNJ8
39 myocardial infarction 29.2 TNNI3 REN PIK3C2A NOS3 KNG1 HTR2A
40 vascular disease 29.1 REN NOS3 KNG1 HTR2A EDN1 CRP
41 lipoprotein quantitative trait locus 29.0 TNNI3 REN PIK3C2A NOS3 KNG1 EDN1
42 congestive heart failure 28.5 TNNI3 REN PIK3C2A NOS3 KNG1 EDN1
43 dilated cardiomyopathy 28.4 TNNI3 REN NOS3 MYLK3 KNG1 KCNJ11
44 heart disease 27.7 TNNI3 REN PIK3C2A NOS3 KNG1 KCNJ11
45 hypertension, essential 27.4 TNNI3 ROCK2 ROCK1 RHOA REN PPP1R12A
46 coronary thrombosis 10.5
47 arteritic anterior ischemic optic neuropathy 10.4 NOS3 ACE
48 atrial fibrillation 10.4
49 acute dacryoadenitis 10.4 CRP ACE
50 cerebral arteritis 10.4 EDN1 CRP

Graphical network of the top 20 diseases related to Coronary Artery Vasospasm:



Diseases related to Coronary Artery Vasospasm

Symptoms & Phenotypes for Coronary Artery Vasospasm

UMLS symptoms related to Coronary Artery Vasospasm:


angina pectoris

MGI Mouse Phenotypes related to Coronary Artery Vasospasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ACE CRP EDN1 KCNJ11 KCNJ8 MYLK3
2 growth/size/body region MP:0005378 10.13 ABCC8 ACE EDN1 KCNJ11 KCNJ8 KNG1
3 homeostasis/metabolism MP:0005376 10.1 ABCC8 ACE CRP EDN1 KCNJ11 KCNJ8
4 immune system MP:0005387 9.93 ACE AOC3 CMA1 CRP KCNJ8 NOS3
5 muscle MP:0005369 9.7 EDN1 HTR2A KCNJ11 KCNJ8 MYLK3 NOS3
6 renal/urinary system MP:0005367 9.23 ACE EDN1 NOS3 PIK3C2A PPP1R12A REN

Drugs & Therapeutics for Coronary Artery Vasospasm

Drugs for Coronary Artery Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
2
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
3
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
4
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
5
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
6
Ramipril Approved Phase 4 87333-19-5 5362129
7
Bisoprolol Approved Phase 4 66722-44-9 2405
8 Antihypertensive Agents Phase 4
9 Hormones Phase 4
10 calcium channel blockers Phase 4
11 Calcium, Dietary Phase 4
12 Adrenergic beta-Agonists Phase 4
13 Adrenergic Agents Phase 4
14 Neurotransmitter Agents Phase 4
15 Adrenergic Agonists Phase 4
16 Mineralocorticoids Phase 4
17 Adrenergic beta-Antagonists Phase 4
18 Mineralocorticoid Receptor Antagonists Phase 4
19 Hormone Antagonists Phase 4
20 diuretics Phase 4
21 Angiotensin-Converting Enzyme Inhibitors Phase 4
22
protease inhibitors Phase 4
23 Diuretics, Potassium Sparing Phase 4
24 HIV Protease Inhibitors Phase 4
25 Sodium Channel Blockers Phase 4
26 Adrenergic Antagonists Phase 4
27 Sympatholytics Phase 4
28 Sodium Potassium Chloride Symporter Inhibitors Phase 4
29 Adrenergic beta-1 Receptor Antagonists Phase 4
30
Calcium Nutraceutical Phase 4 7440-70-2 271
31
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
32
Darapladib Investigational Phase 3 356057-34-6 9939609
33
Acetylcholine Approved, Investigational 51-84-3 187
34 Sodium Chloride Symporter Inhibitors
35 Angiotensin Receptor Antagonists
36 Cholinergic Agents

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm Completed NCT03930433 Phase 4 Nebivolol;Diltiazem;Nebivolol+Diltiazem
2 Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT) Completed NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
3 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans AIM III Completed NCT01067339 Phase 3 darapladib;placebo
4 Efficacy of Diltiazem to Improve Coronary Microvascular Dysfunction: a Randomized Clinical Trial Recruiting NCT04777045 Phase 3 Diltiazem Hydrochloride;Placebo
5 A Randomised, Double-blind, Parallel Group, Efficacy and Safety Study of Transdermal Patch Nitroglycerin in the Prevention of Coronary Artery Spasm, During Coronary Angiography/ Angioplasty (NURSE-TTS - Nitrate Use to Obtain Radial Spasm Embarrassment) Recruiting NCT04766151 Phase 3 Transdermal glyceryl trinitrate 10mg patches;Placebo patches
6 Application of Sildenafil in Patients With Documented Coronary Vasospasm to Explore the Pathophysiology of Coronary Vasospasm and the Therapeutic Effect of Sildenafil in Patients Suffering From Coronary Vasospasm Withdrawn NCT00454714 Phase 3 single dose Sildenafil;Single dose placebo
7 Assessment of Coronary Plaque Composition Using Near Infrared Spectroscopy During Inhibition of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity Completed NCT01581632 Phase 1
8 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level in Hypertensive Patients Treated With Blood Pressure Lowering Drugs Completed NCT01882790
9 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level Completed NCT01877993
10 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans Completed NCT01557088
11 CORonary MICrovascular Angina (CorMicA): a Randomised, Controlled, Pilot Trial Completed NCT03193294
12 Digital Tonometry for Measurement of Peripheral Artery Reactive Hyperemia as Non-invasive Test for Diagnosis of Coronary Artery Spasm Completed NCT00619294
13 Influence of Plasma Glucose Levels on Retinal Vascular Diameter and Choroidal Blood Flow in Vasospastic Subjects Completed NCT00350129
14 The Multicenter Registry to Evaluate the Natural Course of Coronary Spasm Patients Presenting Aborted Sudden Cardiac Death Completed NCT02298543
15 The Clinical Efficacy Comparison of Two Renal Sympathetic Denervation Strategies ---- Full Length Versus Proximal Renal Arteries Ablation Completed NCT01848275
16 Observational Study of the Polymorphisms of the Renin-angiotensin-aldosterone System and Their Relation to Resistant Systemic Arterial Hypertension and Adverse Cardiovascular Events Completed NCT01173029 Anti-hypertensive drug treatment
17 "Reversibility of Cardiovascular Injury With Continuous Positive Airway Pressure (CPAP) Use: Mechanisms Involved" Completed NCT01317329
18 Angina in Patients Without Obstructive Coronary Disease as Revealed by CT Coronary Angiography (Cor-CTCA): an Observational Cohort Study Involving Coronary Function Tests and a Nested Randomised Trial Recruiting NCT03477890
19 Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries Recruiting NCT00921856
20 EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial: An European Registry Recruiting NCT04598308

Search NIH Clinical Center for Coronary Artery Vasospasm

Cochrane evidence based reviews: coronary vasospasm

Genetic Tests for Coronary Artery Vasospasm

Genetic tests related to Coronary Artery Vasospasm:

# Genetic test Affiliating Genes
1 Coronary Artery Spasm 29

Anatomical Context for Coronary Artery Vasospasm

MalaCards organs/tissues related to Coronary Artery Vasospasm:

40
Endothelial, Heart, Smooth Muscle, Kidney, Liver, Colon, Skeletal Muscle

Publications for Coronary Artery Vasospasm

Articles related to Coronary Artery Vasospasm:

(show top 50) (show all 1369)
# Title Authors PMID Year
1
Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction. 54 61
19623039 2009
2
Association of endothelin-1 gene polymorphisms with variant angina in Korean patients. 61 54
19012521 2008
3
Update on evidence for a genetic predisposition to cerebral vasospasm. 61 54
17029342 2006
4
Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. 61 54
16820593 2006
5
Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene. 61 54
16565556 2006
6
Genetic variations in vascular endothelial growth factor and endothelial nitric oxide synthase and their contributions to human disease. 61 54
15825252 2005
7
[Cardioprotective effects of diltiazem infusion in the perioperative period in patients undergoing coronary artery bypass grafting with extracorporeal circulation]. 61 54
14521738 2003
8
Interplanetary travel and permanent injury to normal heart. 61 54
11543600 1997
9
5-HT receptors mediating contractions of the isolated human coronary artery. 61 54
7693489 1993
10
Coronary vasospasm: An infrequent cause of cardiopulmonary arrest. 61
31615714 2021
11
ST-segment elevation myocardial infarction due to multivessel, multifocal coronary vasospasm. 61
32398576 2021
12
Diagnostic approach in patients with angina and no obstructive coronary artery disease: emphasising the role of the coronary function test. 61
33415605 2021
13
Pheochromocytoma-related cardiomyopathy presenting as acute myocardial infarction: A case report. 61
33725969 2021
14
Epirubicin-induced Kounis syndrome. 61
33711934 2021
15
The Importance of Defining the Coronary Anatomy in Suspected Myopericarditis: A Case Report. 61
33780431 2021
16
Kounis Syndrome Following Hypnale zara (Hump-Nosed Pit Viper) Bite in Sri Lanka. 61
33775497 2021
17
Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner. 61
33184836 2021
18
Absolute Coronary Blood Flow Measured by Continuous Thermodilution in Patients With Ischemia and Nonobstructive Disease. 61
33573743 2021
19
Spontaneous coronary artery dissection in association with cabergoline therapy. 61
33563672 2021
20
The role of computed tomography coronary angiography in multi-vessel coronary vasospasm: a case report. 61
33738416 2021
21
Transient complete atrioventricular block and ST-segment elevation induced by coronary vasospasm due to iatrogenic hyperkalemia: a case report. 61
33568154 2021
22
Peripheral Administration of Nitroglycerin in Pulseless Ventricular Tachycardia due to Cocaine-Induced Coronary Vasospasm. 61
33534027 2021
23
The allergic myocardial infarction dilemma: is it the anaphylaxis or the epinephrine? 61
33544285 2021
24
Low-dose corticosteroid therapy improves refractory coronary vasospasm accompanied by eosinophilic granulomatosis with polyangiitis. 61
33520026 2021
25
An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. 61
32624456 2021
26
COVID-19 myopericarditis with cardiac tamponade in the absence of respiratory symptoms: a case report. 61
33494822 2021
27
Paroxysmal Severe Mitral Regurgitation. 61
33413838 2021
28
Coronary Disease in Pregnancy: Myocardial Infarction and Spontaneous Coronary Artery Dissection. 61
32701519 2020
29
Storm and STEMI: a case report of unexpected cardiac complications of thyrotoxicosis. 61
33442653 2020
30
Recurrent Coronary Vasospasm After Cardiac Surgery. 61
32511994 2020
31
Coronary vasospasm-induced syncope with dynamic changes of regional wall motion abnormalities confirmed real-time: a case report. 61
33629012 2020
32
Recurrent Lethal Allergic Coronary Vasospasm. 61
32497541 2020
33
Coronary vasospasm in eosinophilic granulomatosis with polyangiitis. 61
32756991 2020
34
PDE1 or PDE5 inhibition augments NO-dependent hypoxic constriction of porcine coronary artery via elevating inosine 3',5'-cyclic monophosphate level. 61
33169529 2020
35
An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. 61
32626906 2020
36
Decreased Double Product at Rest in Patients With Severe Vasospasm. 61
32224086 2020
37
A Case of 5-Fluorouracil-Induced Coronary Artery Vasospasm in a Patient With Salivary Gland Cancer. 61
33178539 2020
38
Pathogenesis of Ventricular Arrhythmias and Its Effect on Long-Term Prognosis in Patients With Takotsubo Cardiomyopathy. 61
33262908 2020
39
Prinzmetal Angina Mimicking Severe Three-Vessel Coronary Artery Disease. 61
32865511 2020
40
Diagnostic and Prognostic Value of Ergonovine Echocardiography for Noninvasive Diagnosis of Coronary Vasospasm. 61
32417336 2020
41
A case of chemotherapy-induced coronary vasospasm in a patient with colorectal cancer. 61
32884592 2020
42
A Review of the Evidence for Treatment of Myocardial Infarction With Nonobstructive Coronary Arteries. 61
32995725 2020
43
A pragmatic diagnostic approach to myocardial infarction with non-obstructive coronary arteries. 61
32994622 2020
44
Right Coronary Artery Vasospasm Presenting as Complete Atrioventricular Block. 61
32716481 2020
45
Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report. 61
33014294 2020
46
The complication rate of intravascular ultrasound (IVUS) in a multicenter pediatric heart transplant population: A study of the international pediatric IVUS consortium. 61
32720750 2020
47
Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? 61
32870171 2020
48
Coronary Vasospasm After Dobutamine Stress Echocardiogram Triggered by Esmolol. 61
32983711 2020
49
ST segment elevation in an adult chest pain patient: A case of coronary artery vasospasm. 61
32402497 2020
50
Why Improve Our Knowledge and Clinical Practice in the Management of Patients With Coronary Vasospasm? 61
32739306 2020

Variations for Coronary Artery Vasospasm

Expression for Coronary Artery Vasospasm

Search GEO for disease gene expression data for Coronary Artery Vasospasm.

Pathways for Coronary Artery Vasospasm

Pathways related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 ROCK2 ROCK1 RHOA PPP1R12A PIK3C2A NOS3
2 12.78 ROCK2 ROCK1 RHOA KNG1 EDN1
3
Show member pathways
12.59 ROCK2 ROCK1 RHOA PPP1R12A NOS3
4
Show member pathways
12.48 ROCK2 ROCK1 RHOA PPP1R12A MYLK3
5 12.44 ROCK2 ROCK1 RHOA PPP1R12A PIK3C2A MYLK3
6
Show member pathways
12.43 ROCK2 ROCK1 RHOA NOS3
7 12.43 TNNI3 ROCK2 ROCK1 RHOA PPP1R12A
8
Show member pathways
12.4 ROCK2 ROCK1 RHOA PIK3C2A NOS3
9
Show member pathways
12.36 ROCK2 ROCK1 RHOA PPP1R12A
10
Show member pathways
12.32 ROCK2 ROCK1 RHOA PPP1R12A MYLK3
11 12.25 ROCK2 ROCK1 RHOA PPP1R12A
12
Show member pathways
12.22 ROCK2 ROCK1 RHOA PPP1R12A MYLK3
13 12.18 ROCK2 RHOA PPP1R12A MYLK3
14 12.18 TNNI3 ROCK2 ROCK1 RHOA PPP1R12A EDN1
15
Show member pathways
12.16 ROCK2 ROCK1 RHOA PPP1R12A NOS3 MYLK3
16
Show member pathways
12.11 ROCK2 ROCK1 PPP1R12A PIK3C2A
17
Show member pathways
12.06 ROCK2 ROCK1 RHOA MYLK3 EDN1
18 11.88 ROCK2 ROCK1 RHOA NOS3 KNG1
19
Show member pathways
11.83 PIK3C2A KCNJ11 ABCC8
20 11.83 ROCK2 ROCK1 RHOA
21
Show member pathways
11.81 ROCK1 RHOA NOS3
22 11.8 ROCK2 ROCK1 RHOA
23
Show member pathways
11.78 TNNI3 ROCK2 ROCK1 RHOA PPP1R12A NOS3
24 11.66 REN EDN1 ACE
25 11.64 ROCK1 RHOA NOS3
26
Show member pathways
11.56 REN NOS3 KNG1 CMA1 ACE
27 11.55 KCNJ8 KCNJ11 ABCC8
28 11.53 ROCK2 ROCK1 RHOA PPP1R12A NOS3 MYLK3
29
Show member pathways
11.51 ROCK2 RHOA PPP1R12A
30 11.48 ROCK2 ROCK1 RHOA
31 11.48 ROCK2 ROCK1 RHOA PPP1R12A
32 11.46 ROCK1 RHOA KNG1
33 11.43 ROCK2 ROCK1 RHOA
34 11.42 ROCK1 RHOA PIK3C2A
35 11.41 ROCK1 RHOA NOS3
36 11.35 ROCK2 ROCK1 RHOA
37 11.35 ROCK2 ROCK1 RHOA PPP1R12A
38 11.09 ROCK2 RHOA NOS3

GO Terms for Coronary Artery Vasospasm

Cellular components related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.17 TNNI3 ROCK2 ROCK1 RHOA REN PPP1R12A
2 plasma membrane GO:0005886 9.8 ROCK2 ROCK1 RHOA REN PPP1R12A PIK3C2A
3 cell body fiber GO:0070852 9.26 KCNJ11 HTR2A
4 potassium ion-transporting ATPase complex GO:0031004 9.16 KCNJ8 ABCC8
5 inward rectifying potassium channel GO:0008282 8.8 KCNJ8 KCNJ11 ABCC8

Biological processes related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.83 REN NOS3 KCNJ8 EDN1 ABCC8
2 ephrin receptor signaling pathway GO:0048013 9.82 ROCK2 ROCK1 RHOA
3 regulation of actin cytoskeleton organization GO:0032956 9.81 ROCK2 ROCK1 RHOA
4 cellular response to drug GO:0035690 9.8 REN PPP1R12A EDN1
5 response to drug GO:0042493 9.8 RHOA REN KCNJ11 HTR2A EDN1 ABCC8
6 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.79 ROCK2 ROCK1 RHOA
7 Rho protein signal transduction GO:0007266 9.78 ROCK2 ROCK1 RHOA
8 regulation of cell adhesion GO:0030155 9.77 ROCK2 ROCK1 PPP1R12A
9 regulation of blood pressure GO:0008217 9.76 REN NOS3 EDN1 ACE
10 phosphatidylinositol 3-kinase signaling GO:0014065 9.74 PIK3C2A HTR2A EDN1
11 regulation of cell motility GO:2000145 9.72 ROCK2 ROCK1 RHOA
12 aortic valve morphogenesis GO:0003180 9.71 ROCK2 ROCK1 NOS3
13 regulation of focal adhesion assembly GO:0051893 9.69 ROCK2 ROCK1 RHOA
14 positive regulation of cardiac muscle hypertrophy GO:0010613 9.67 ROCK2 ROCK1 EDN1
15 positive regulation of connective tissue replacement GO:1905205 9.65 ROCK2 ROCK1
16 amyloid-beta metabolic process GO:0050435 9.65 REN ACE
17 negative regulation of blood coagulation GO:0030195 9.65 KNG1 EDN1
18 inorganic cation transmembrane transport GO:0098662 9.65 KCNJ8 KCNJ11 ABCC8
19 artery smooth muscle contraction GO:0014824 9.64 HTR2A EDN1
20 negative regulation of bicellular tight junction assembly GO:1903347 9.62 ROCK2 ROCK1
21 regulation of cell junction assembly GO:1901888 9.62 ROCK2 ROCK1
22 positive regulation of sarcomere organization GO:0060298 9.6 MYLK3 EDN1
23 response to angiotensin GO:1990776 9.58 ROCK2 ROCK1
24 negative regulation of myosin-light-chain-phosphatase activity GO:0035509 9.58 ROCK2 ROCK1
25 angiotensin maturation GO:0002003 9.58 REN CMA1 ACE
26 regulation of neurological system process GO:0031644 9.56 ROCK2 NOS3
27 response to transforming growth factor beta GO:0071559 9.54 ROCK2 ROCK1 EDN1
28 regulation of angiotensin-activated signaling pathway GO:0110061 9.52 ROCK2 ROCK1
29 regulation of establishment of endothelial barrier GO:1903140 9.43 ROCK2 ROCK1 PPP1R12A
30 negative regulation of biomineral tissue development GO:0070168 9.33 ROCK2 ROCK1 NOS3
31 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.13 RHOA NOS3 EDN1
32 regulation of blood vessel diameter GO:0097746 8.92 ROCK2 ROCK1 NOS3 ACE

Molecular functions related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rho GTPase binding GO:0017048 9.26 ROCK2 ROCK1
2 Rho-dependent protein serine/threonine kinase activity GO:0072518 9.16 ROCK2 ROCK1
3 cation-transporting ATPase activity GO:0019829 9.13 KCNJ8 KCNJ11 ABCC8
4 ATP-activated inward rectifier potassium channel activity GO:0015272 8.8 KCNJ8 KCNJ11 ABCC8

Sources for Coronary Artery Vasospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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