MCID: CRN019
MIFTS: 46

Coronary Artery Vasospasm

Categories: Cardiovascular diseases

Aliases & Classifications for Coronary Artery Vasospasm

MalaCards integrated aliases for Coronary Artery Vasospasm:

Name: Coronary Artery Vasospasm 12 15 71
Coronary Vasospasm 12 54 43 17
Coronary Artery Spasm 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:11840
MeSH 43 D003329
NCIt 49 C34515
SNOMED-CT 67 23687008
UMLS 71 C0010073

Summaries for Coronary Artery Vasospasm

MalaCards based summary : Coronary Artery Vasospasm, also known as coronary vasospasm, is related to angina pectoris and intermediate coronary syndrome, and has symptoms including angina pectoris An important gene associated with Coronary Artery Vasospasm is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Diltiazem and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Coronary vasospasm is a sudden, intense vasoconstriction of an epicardial coronary artery that causes... more...

Related Diseases for Coronary Artery Vasospasm

Diseases related to Coronary Artery Vasospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 angina pectoris 32.8 TNNI3 NOS3 KNG1 EDN1 CRP ADRB1
2 intermediate coronary syndrome 30.7 TNNI3 CRP ACE
3 coronary stenosis 30.7 TNNI3 CRP ACE
4 aortic valve insufficiency 30.7 TNNI3 CRP ACE
5 raynaud phenomenon 30.6 HTR2A EDN1 ADRA2C
6 mitral valve insufficiency 30.6 TNNI3 CRP ACE
7 left bundle branch hemiblock 30.6 TNNI3 CRP ACE
8 acute myocarditis 30.6 TNNI3 CRP ACE
9 pericarditis 30.5 TNNI3 CRP ACE
10 ischemia 30.5 NOS3 KNG1 EDN1 ACE
11 silent myocardial infarction 30.4 TNNI3 CRP ACE
12 atherosclerosis susceptibility 30.4 NOS3 EDN1 CRP ACE
13 eclampsia 30.4 NOS3 EDN1 ACE
14 arteries, anomalies of 30.4 TNNI3 NOS3 EDN1 CRP ACE
15 constrictive pericarditis 30.3 TNNI3 CRP ACE
16 hypercholesterolemia, familial, 1 30.3 NOS3 CRP ACE
17 atrial fibrillation 30.2 TNNI3 NOS3 CRP ADRB1 ACE
18 coronary heart disease 1 30.2 NOS3 EDN1 CRP ACE
19 fabry disease 30.2 TNNI3 NOS3 CRP
20 acute myocardial infarction 30.2 TNNI3 EDN1 CRP ADRB1 ACE
21 limb ischemia 30.2 TNNI3 NOS3 EDN1 ACE
22 mitral valve disease 30.1 TNNI3 NOS3 CRP ACE
23 pulmonary embolism 30.1 TNNI3 CRP ACE
24 atrial standstill 1 30.1 TNNI3 ADRB1 ACE
25 atrial heart septal defect 30.0 TNNI3 EDN1 CRP ACE
26 arteriosclerosis 29.9 RHOA NOS3 EDN1 CRP ACE
27 migraine with or without aura 1 29.8 NOS3 KNG1 HTR2A EDN1 CRP ACE
28 pulmonary edema 29.8 TNNI3 NOS3 KNG1 EDN1 CRP ACE
29 chronic kidney disease 29.8 TNNI3 NOS3 EDN1 CRP ACE
30 myocardial stunning 29.7 TNNI3 NOS3 KNG1 EDN1 AHSP ACE
31 lipoprotein quantitative trait locus 29.7 TNNI3 NOS3 KNG1 EDN1 CRP ADRB1
32 peripheral vascular disease 29.6 NOS3 KNG1 HTR2A CRP ACE
33 hypertrophic cardiomyopathy 29.6 TNNI3 RHOA NOS3 KCNJ8 EDN1 ACE
34 orthostatic intolerance 29.2 NOS3 EDN1 ADRB1 ADRA2C ADRA2B ADRA2A
35 heart disease 28.8 TNNI3 NOS3 KNG1 EDN1 CRP CMA1
36 vascular disease 28.8 NOS3 KNG1 HTR2A EDN1 CRP CMA1
37 dilated cardiomyopathy 28.8 TNNI3 NOS3 KNG1 EDN1 CRP ADRB1
38 congestive heart failure 28.5 TNNI3 NOS3 KNG1 EDN1 CRP AOC3
39 myocardial infarction 28.4 TNNI3 NOS3 KNG1 HTR2A EDN1 CRP
40 attention deficit-hyperactivity disorder 28.3 HTR2A ADRB1 ADRA2C ADRA2B ADRA2A ADRA1A
41 hypertension, essential 24.8 TNNI3 RHOA PPP1R12A NOS3 KNG1 HTR2A
42 atrioventricular block 10.5
43 coronary thrombosis 10.5
44 mediastinum teratoma 10.4 CRP ACE
45 chronic thromboembolic pulmonary hypertension 10.4 EDN1 CRP
46 toxic myocarditis 10.4 TNNI3 ACE
47 acute dacryoadenitis 10.4 CRP ACE
48 cardiac tuberculosis 10.4 CRP ACE
49 diabetic angiopathy 10.4 NOS3 EDN1 AOC3
50 facial hemiatrophy 10.4 KANTR CRP

Graphical network of the top 20 diseases related to Coronary Artery Vasospasm:



Diseases related to Coronary Artery Vasospasm

Symptoms & Phenotypes for Coronary Artery Vasospasm

UMLS symptoms related to Coronary Artery Vasospasm:


angina pectoris

MGI Mouse Phenotypes related to Coronary Artery Vasospasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 ACE ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C
2 homeostasis/metabolism MP:0005376 10.07 ACE ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C
3 mortality/aging MP:0010768 9.97 ACE ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C
4 muscle MP:0005369 9.65 ADRA1A ADRA1B ADRA2B ADRB1 EDN1 HTR2A
5 renal/urinary system MP:0005367 9.23 ACE ADRA1A ADRA1B ADRA2B EDN1 NOS3

Drugs & Therapeutics for Coronary Artery Vasospasm

Drugs for Coronary Artery Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
2
Nebivolol Approved, Investigational Phase 4 99200-09-6, 118457-14-0, 152520-56-4 71301
3
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
4
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
5
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
6
Ramipril Approved Phase 4 87333-19-5 5362129
7
Bisoprolol Approved Phase 4 66722-44-9 2405
8
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
9
Atorvastatin Approved Phase 4 134523-00-5 60823
10
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
11
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
12 Tocotrienol Investigational Phase 4 6829-55-6
13 Antihypertensive Agents Phase 4
14 Neurotransmitter Agents Phase 4
15 Adrenergic beta-Agonists Phase 4
16 Adrenergic Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Adrenergic beta-Antagonists Phase 4
19 Mineralocorticoid Receptor Antagonists Phase 4
20 Mineralocorticoids Phase 4
21 Hormone Antagonists Phase 4
22 Angiotensin-Converting Enzyme Inhibitors Phase 4
23
protease inhibitors Phase 4
24 diuretics Phase 4
25 HIV Protease Inhibitors Phase 4
26 Diuretics, Potassium Sparing Phase 4
27 Adrenergic beta-1 Receptor Antagonists Phase 4
28 Sodium Channel Blockers Phase 4
29 Adrenergic Antagonists Phase 4
30 Sodium Potassium Chloride Symporter Inhibitors Phase 4
31 Sympatholytics Phase 4
32 Antimetabolites Phase 4
33 Hormones Phase 4
34 Calcium, Dietary Phase 4
35 calcium channel blockers Phase 4
36 Trace Elements Phase 4
37 Vitamins Phase 4
38 Antioxidants Phase 4
39 Nutrients Phase 4
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
41 Lipid Regulating Agents Phase 4
42 Protective Agents Phase 4
43 Micronutrients Phase 4
44 Hypolipidemic Agents Phase 4
45 Tocotrienols Phase 4
46 Tocopherols Phase 4
47 Anticholesteremic Agents Phase 4
48
Calcium Nutraceutical Phase 4 7440-70-2 271
49
Darapladib Investigational Phase 3 356057-34-6 9939609
50
Tegafur Approved, Investigational Phase 2 17902-23-7 5386

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm Completed NCT03930433 Phase 4 Nebivolol;Diltiazem;Nebivolol+Diltiazem
2 Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT) Completed NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
3 Effects of Long-term Vitamin C+E and Statin Therapy on Vasospasm Improvement and Regression of Atheroma in Patients With Variant Angina Recruiting NCT03228238 Phase 4 Vitamin C and Vitamin E;Statin;Standard medication for variant angina
4 Calcium Administration in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass (ICARUS Trial): Prospective Randomized, Double-blind Placebo-controlled Superiority Trial Recruiting NCT03772990 Phase 4 Calcium Chloride;0.9% Sodium Chloride
5 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans AIM III Completed NCT01067339 Phase 3 darapladib;placebo
6 Application of Sildenafil in Patients With Documented Coronary Vasospasm to Explore the Pathophysiology of Coronary Vasospasm and the Therapeutic Effect of Sildenafil in Patients Suffering From Coronary Vasospasm Withdrawn NCT00454714 Phase 3 single dose Sildenafil;Single dose placebo
7 Toxicity OF Fluoropyrimidines: A Comparative Study of the Cardiotoxicity of capEcitabine and tEysuno Active, not recruiting NCT01845337 Phase 2 Teysuno;Capecitabine
8 Assessment of Coronary Plaque Composition Using Near Infrared Spectroscopy During Inhibition of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity Completed NCT01581632 Phase 1
9 Clinical Observation of CHD Phlegm and Blood-stasis Syndrome Patients Unknown status NCT02967718
10 Panic Disorder and Cardiac Risk: Evaluation of a Psychological Treatment Which Addresses Biology, Psychology and Behaviour Unknown status NCT00168506 SSRI;CBT;CBT/SSRI
11 Correlation Between Abnormal Coronary Vasoreactivity Testing, Expansion of CD4+CD28null T Cells and Biomarkers for Inflammation and Endothelial Dysfunction in Patients With Angina Despite Angiographically Normal Coronary Arteries. Unknown status NCT01162824 Acetylcholine;Adenosine
12 The Use of Cardiovascular Biomarkers in Abdominal Aortic Surgery: Possibility of Risk Assessment and Stratification Unknown status NCT02122497
13 Digital Tonometry for Measurement of Peripheral Artery Reactive Hyperemia as Non-invasive Test for Diagnosis of Coronary Artery Spasm Completed NCT00619294
14 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level in Hypertensive Patients Treated With Blood Pressure Lowering Drugs Completed NCT01882790
15 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level Completed NCT01877993
16 The Multicenter Registry to Evaluate the Natural Course of Coronary Spasm Patients Presenting Aborted Sudden Cardiac Death Completed NCT02298543
17 CORonary MICrovascular Angina (CorMicA): a Randomised, Controlled, Pilot Trial Completed NCT03193294
18 "Reversibility of Cardiovascular Injury With Continuous Positive Airway Pressure (CPAP) Use: Mechanisms Involved" Completed NCT01317329
19 Influence of Plasma Glucose Levels on Retinal Vascular Diameter and Choroidal Blood Flow in Vasospastic Subjects Completed NCT00350129
20 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans Completed NCT01557088
21 The Clinical Efficacy Comparison of Two Renal Sympathetic Denervation Strategies ---- Full Length Versus Proximal Renal Arteries Ablation Completed NCT01848275
22 Observational Study of the Polymorphisms of the Renin-angiotensin-aldosterone System and Their Relation to Resistant Systemic Arterial Hypertension and Adverse Cardiovascular Events Completed NCT01173029 Anti-hypertensive drug treatment
23 The Evaluation of the Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG Imaging Completed NCT01432626 I-123 radiolabeled metaiodobenzylguanidine cardiac imaging
24 Dual-acquisition of Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry Recruiting NCT03570671
25 Computed Tomography Angiography Prediction Score for Side Branch Occlusion in Coronary Bifurcation Intervention (CT-PRECISION) Recruiting NCT03709836
26 NYU Takotsubo (Broken Heart Syndrome) Registry Recruiting NCT03663348
27 Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries Recruiting NCT00921856
28 Angina in Patients Without Obstructive Coronary Disease as Revealed by CT Coronary Angiography (Cor-CTCA): an Observational Cohort Study Involving Coronary Function Tests and a Nested Randomised Trial Recruiting NCT03477890
29 Canadian Spontaneous Coronary Artery Dissection (SCAD) Cohort Study Active, not recruiting NCT02188069

Search NIH Clinical Center for Coronary Artery Vasospasm

Cochrane evidence based reviews: coronary vasospasm

Genetic Tests for Coronary Artery Vasospasm

Genetic tests related to Coronary Artery Vasospasm:

# Genetic test Affiliating Genes
1 Coronary Artery Spasm 29

Anatomical Context for Coronary Artery Vasospasm

MalaCards organs/tissues related to Coronary Artery Vasospasm:

40
Heart, Testes, Endothelial, Smooth Muscle, T Cells, Monocytes, Kidney

Publications for Coronary Artery Vasospasm

Articles related to Coronary Artery Vasospasm:

(show top 50) (show all 1318)
# Title Authors PMID Year
1
Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction. 61 54
19623039 2009
2
Association of endothelin-1 gene polymorphisms with variant angina in Korean patients. 61 54
19012521 2008
3
Update on evidence for a genetic predisposition to cerebral vasospasm. 54 61
17029342 2006
4
Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. 54 61
16820593 2006
5
Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene. 54 61
16565556 2006
6
Genetic variations in vascular endothelial growth factor and endothelial nitric oxide synthase and their contributions to human disease. 54 61
15825252 2005
7
[Cardioprotective effects of diltiazem infusion in the perioperative period in patients undergoing coronary artery bypass grafting with extracorporeal circulation]. 61 54
14521738 2003
8
Interplanetary travel and permanent injury to normal heart. 54 61
11543600 1997
9
5-HT receptors mediating contractions of the isolated human coronary artery. 61 54
7693489 1993
10
Recurrent Coronary Vasospasm After Cardiac Surgery. 61
32511994 2020
11
Recurrent Lethal Allergic Coronary Vasospasm. 61
32497541 2020
12
Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm. 61
32498247 2020
13
Acute Coronary Syndrome with Non-ruptured Plaques (NONRUPLA): Novel Ideas and Perspectives. 61
32468244 2020
14
Coronary artery dissection due to severe coronary vasospasm during ergonovine provocation test. 61
31658136 2020
15
Vasospasm-related Sudden Cardiac Death Has Outcomes Comparable with Coronary Stenosis in Out-of-Hospital Cardiac Arrest. 61
32419397 2020
16
Diagnostic and Prognostic Value of Ergonovine Echocardiography for Noninvasive Diagnosis of Coronary Vasospasm. 61
32417336 2020
17
ST-segment elevation myocardial infarction due to multivessel, multifocal coronary vasospasm. 61
32398576 2020
18
Death of an apprentice bodybuilder following 2,4-dinitrophenol and clenbuterol intake. 61
32125503 2020
19
Recurrent ST Elevation Myocardial Infarction from Norepinephrine-induced Coronary Vasospasm. 61
32399339 2020
20
Vasospastic Arrest:: A Heart-Stopping Case of Prinzmetal Angina. 61
32432226 2020
21
ST segment elevation in an adult chest pain patient: A case of coronary artery vasospasm. 61
32402497 2020
22
Decreased Double Product at Rest in Patients with Severe Vasospasm. 61
32224086 2020
23
Fluoropyrimidine-Associated Cardiotoxicity: A Retrospective Case-Control Study. 61
32162823 2020
24
A rare case of atropine-resistant bradycardia following sugammadex administration. 61
32124089 2020
25
Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry). 61
31185091 2020
26
Computed Tomographic Angiography-Verified Myocardial Bridge and Invasive Angiography-Verified Left Anterior Descending Coronary Artery Vasospasm. 61
31548153 2020
27
Myocardial Infarction Secondary to Marijuana-Induced Coronary Vasospasm. 61
32149186 2020
28
Acute Myocardial Infarction in Young Individuals. 61
31902409 2020
29
Coronary vasospasm induced by cisplatin for seminoma. 61
31998514 2020
30
ST Elevations and Ventricular Tachycardia Secondary to Coronary Vasospasm upon Extubation. 61
32099682 2020
31
Management of Angina Post Percutaneous Coronary Intervention. 61
31965355 2020
32
Hypercalcemia-Induced ST-Segment Elevation Mimicking Acute Myocardial Injury: A Case Report and Review of the Literature. 61
32257460 2020
33
Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon. 61
31856732 2019
34
Fluoropyrimidine-Associated Cardiotoxicity: A Retrospective Case-Control Study. 61
31843972 2019
35
Kounis syndrome uncovers severe coronary disease: an unusual case of acute coronary syndrome secondary to allergic coronary vasospasm. 61
31874849 2019
36
Coronary artery vasospasm after misoprostol treatment for incomplete abortion: a case report. 61
31446021 2019
37
Risk of vasopressin use: a case of acute pulmonary oedema, post intramyometrial infiltration of vasopressin in laparoscopic myomectomy. 61
31831516 2019
38
Coronary vasospasm caused by intravenous infusion of dexmedetomidine: Unrecognized pitfall of catheter ablation procedures of atrial fibrillation. 61
31762838 2019
39
Fluoropyrimidine-Associated Cardiotoxicity. 61
31587781 2019
40
Ventricular fibrillation in a patient with Wolff-Parkinson-White syndrome unrelated to pre-excited atrial fibrillation. 61
31141244 2019
41
Ventricular Fibrillation Cardiac Arrest in Young Female from Diffuse Left Anterior Descending Coronary Vasospasm. 61
31763597 2019
42
Diagnosis of malignant coronary vasospasm by 12-lead Holter electrocardiogram and optical coherence tomography. 61
31638699 2019
43
To study the usefulness and comparison of myocardial strain imaging by 2D and 3D echocardiography for early detection of cardiotoxicity in patients undergoing cardiotoxic chemotherapy. 61
32248920 2019
44
Coronary vasospasm: An infrequent cause of cardiopulmonary arrest. 61
31615714 2019
45
[Coronary vasospasm in a child allergic to latex: Kounis syndrome]. 61
31560503 2019
46
Successful 5-fluorouracil (5-FU) infusion re-challenge in a metastatic colorectal cancer patient with coronary artery disease who experienced symptoms consistent with coronary vasospasm during first 5-FU infusion. 61
31602339 2019
47
Acute inferior ST-elevation myocardial infarction due to delirium tremens: a case report. 61
31597573 2019
48
Is there a role for remote ischemic conditioning in preventing 5-fluorouracil-induced coronary vasospasm? 61
32133437 2019
49
Vancomycin-induced Kounis Syndrome. 61
31182359 2019
50
An unusual complication during alcohol septal ablation: severe left anterior descending artery vasospasm causing cardiac arrest: a case report and review of the literature. 61
31425578 2019

Variations for Coronary Artery Vasospasm

Expression for Coronary Artery Vasospasm

Search GEO for disease gene expression data for Coronary Artery Vasospasm.

Pathways for Coronary Artery Vasospasm

Pathways related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 RHOA PPP1R12A NOS3 KNG1 HTR2A EDN1
2
Show member pathways
13.45 KNG1 HTR2A EDN1 ADRB1 ADRA2C ADRA2B
3
Show member pathways
13.36 TNNI3 RHOA PPP1R12A NOS3 CRP ADRB1
4
Show member pathways
12.72 RHOA EDN1 ADRB1 ADRA2B ADRA2A ADRA1B
5
Show member pathways
12.37 NOS3 ADRB1 ADRA1B ADRA1A
6
Show member pathways
12.34 RHOA PPP1R12A NOS3 EDN1 ADRA1B ADRA1A
7
Show member pathways
12.33 PPP1R12A NOS3 ADRA1B ADRA1A
8 12.23 TNNI3 RHOA PPP1R12A EDN1 ADRB1
9
Show member pathways
12.16 NOS3 HTR2A ADRB1 ADRA1B ADRA1A
10
Show member pathways
12.12 TNNI3 EDN1 ADRB1 ACE
11
Show member pathways
11.97 NOS3 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
12
Show member pathways
11.9 TNNI3 RHOA PPP1R12A NOS3 KNG1 KCNJ8
13
Show member pathways
11.74 HTR2A ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
14
Show member pathways
11.73 ADRA2C ADRA2B ADRA2A
15
Show member pathways
11.68 NOS3 KNG1 CMA1 ACE
16 11.57 EDN1 ADRB1 ACE
17 11.46 KCNJ8 ADRB1 ADRA2A
18 11.15 NOS3 EDN1 ADRB1 ADRA1A
19 10.79 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A

GO Terms for Coronary Artery Vasospasm

Cellular components related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.21 TNNI3 RHOA PPP1R12A NOS3 HTR2A EDN1
2 plasma membrane GO:0005886 10 RHOA PPP1R12A NOS3 KNG1 KCNJ8 HTR2A
3 integral component of plasma membrane GO:0005887 9.87 HTR2A ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
4 cell GO:0005623 9.56 TNNI3 NOS3 KNG1 HTR2A EDN1 CMA1
5 integral component of postsynaptic membrane GO:0099055 9.43 HTR2A ADRA2C ADRA1A
6 contractile fiber GO:0043292 9.4 TNNI3 PPP1R12A
7 caveola GO:0005901 8.92 NOS3 HTR2A ADRA1B ADRA1A

Biological processes related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.26 PPP1R12A HTR2A ADRB1 ADRA2C ADRA2B ADRA2A
2 G protein-coupled receptor signaling pathway GO:0007186 10.19 RHOA KNG1 HTR2A EDN1 ADRB1 ADRA2C
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.96 KNG1 HTR2A EDN1 ADRA1B ADRA1A
4 positive regulation of MAPK cascade GO:0043410 9.95 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
5 cell-cell signaling GO:0007267 9.91 EDN1 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
6 platelet activation GO:0030168 9.83 ADRA2C ADRA2B ADRA2A
7 positive regulation of neuron differentiation GO:0045666 9.82 RHOA ADRA2C ADRA2B
8 positive regulation of MAP kinase activity GO:0043406 9.79 HTR2A EDN1 ADRA2A
9 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.78 HTR2A ADRA1B ADRA1A
10 regulation of blood pressure GO:0008217 9.77 NOS3 EDN1 ACE
11 activation of protein kinase B activity GO:0032148 9.76 ADRA2C ADRA2B ADRA2A
12 regulation of muscle contraction GO:0006937 9.74 TNNI3 ADRA1B ADRA1A
13 positive regulation of smooth muscle contraction GO:0045987 9.73 RHOA EDN1 ADRA1B ADRA1A
14 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.73 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
15 positive regulation of vasoconstriction GO:0045907 9.72 RHOA HTR2A ADRA2C ADRA1B ADRA1A
16 negative regulation of norepinephrine secretion GO:0010700 9.71 ADRA2C ADRA2B ADRA2A
17 regulation of smooth muscle contraction GO:0006940 9.71 TNNI3 ADRA2C ADRA2B ADRA2A
18 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.7 RHOA NOS3 EDN1
19 receptor transactivation GO:0035624 9.69 ADRA2C ADRA2B ADRA2A
20 heart contraction GO:0060047 9.65 TNNI3 ACE
21 negative regulation of epinephrine secretion GO:0032811 9.65 ADRA2C ADRA2B ADRA2A
22 negative regulation of calcium ion transport GO:0051926 9.64 NOS3 ADRA2A
23 negative regulation of blood coagulation GO:0030195 9.64 KNG1 EDN1
24 angiotensin maturation GO:0002003 9.63 CMA1 ACE
25 positive regulation of systemic arterial blood pressure GO:0003084 9.63 ADRA1A ACE
26 positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 9.63 ADRB1 ADRA1B ADRA1A
27 negative regulation of potassium ion transport GO:0043267 9.62 NOS3 HTR2A
28 artery smooth muscle contraction GO:0014824 9.62 HTR2A EDN1
29 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.59 ADRA1B ADRA1A
30 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 9.58 ADRB1 ADRA1A
31 adrenergic receptor signaling pathway GO:0071875 9.55 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
32 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.43 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
33 regulation of vasoconstriction GO:0019229 9.17 EDN1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A

Molecular functions related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.87 HTR2A ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B
2 protein heterodimerization activity GO:0046982 9.73 AOC3 ADRB1 ADRA2C ADRA2A ADRA1B ADRA1A
3 norepinephrine binding GO:0051380 9.43 ADRB1 ADRA2A
4 alpha-2A adrenergic receptor binding GO:0031694 9.4 ADRB1 ADRA2C
5 alpha1-adrenergic receptor activity GO:0004937 9.37 ADRA1B ADRA1A
6 alpha2-adrenergic receptor activity GO:0004938 9.33 ADRA2C ADRA2B ADRA2A
7 epinephrine binding GO:0051379 9.26 ADRB1 ADRA2C ADRA2B ADRA2A
8 adrenergic receptor activity GO:0004935 9.1 ADRB1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A

Sources for Coronary Artery Vasospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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