MCID: CRN019
MIFTS: 46

Coronary Artery Vasospasm

Categories: Cardiovascular diseases

Aliases & Classifications for Coronary Artery Vasospasm

MalaCards integrated aliases for Coronary Artery Vasospasm:

Name: Coronary Artery Vasospasm 12 15 71
Coronary Vasospasm 12 54 43 17
Coronary Artery Spasm 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:11840
MeSH 43 D003329
NCIt 49 C34515
SNOMED-CT 67 23687008
UMLS 71 C0010073

Summaries for Coronary Artery Vasospasm

MalaCards based summary : Coronary Artery Vasospasm, also known as coronary vasospasm, is related to angina pectoris and raynaud phenomenon, and has symptoms including angina pectoris An important gene associated with Coronary Artery Vasospasm is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Peptide ligand-binding receptors and Activation of cAMP-Dependent PKA. The drugs Diltiazem and Nebivolol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are cardiovascular system and behavior/neurological

Wikipedia : 74 Coronary vasospasm is a sudden, intense vasoconstriction of an epicardial coronary artery that causes... more...

Related Diseases for Coronary Artery Vasospasm

Diseases related to Coronary Artery Vasospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 angina pectoris 32.3 TNNI3 PIK3C2A NOS3 KNG1 EDN1 CRP
2 raynaud phenomenon 30.7 HTR2A EDN1 ADRA2C
3 mitral valve insufficiency 30.6 TNNI3 CRP ACE
4 acute myocarditis 30.6 TNNI3 CRP ACE
5 pericarditis 30.5 TNNI3 CRP ACE
6 atrioventricular block 30.5 TNNI3 PIK3C2A ACE
7 atrial fibrillation 30.5 TNNI3 NOS3 CRP ACE
8 silent myocardial infarction 30.4 TNNI3 CRP ACE
9 eclampsia 30.4 NOS3 EDN1 ACE
10 atherosclerosis susceptibility 30.4 NOS3 EDN1 CRP ACE
11 constrictive pericarditis 30.3 TNNI3 CRP ACE
12 hypercholesterolemia, familial, 1 30.2 NOS3 CRP ACE
13 fabry disease 30.2 TNNI3 NOS3 CRP
14 coronary heart disease 1 30.2 NOS3 EDN1 CRP ACE
15 mitral valve disease 30.1 TNNI3 NOS3 CRP ACE
16 atrial heart septal defect 30.0 TNNI3 EDN1 CRP ACE
17 pulmonary embolism 30.0 TNNI3 CRP ACE
18 angioedema 29.9 KNG1 CRP ACE
19 exanthem 29.9 PIK3C2A CRP ACE
20 myocardial stunning 29.9 TNNI3 KNG1 EDN1 AHSP ACE
21 arteriosclerosis 29.9 RHOA NOS3 EDN1 CRP ACE
22 intermediate coronary syndrome 29.8 TNNI3 PIK3C2A CRP ACE
23 coronary stenosis 29.8 TNNI3 PIK3C2A CRP ACE
24 orthostatic intolerance 29.8 NOS3 EDN1 ADRA2C ADRA2B ADRA2A ACE
25 arteries, anomalies of 29.8 TNNI3 NOS3 KNG1 EDN1 CRP ACE
26 chronic kidney disease 29.8 TNNI3 NOS3 EDN1 CRP ACE
27 left bundle branch hemiblock 29.7 TNNI3 PIK3C2A CRP ACE
28 migraine with or without aura 1 29.7 NOS3 KNG1 HTR2A EDN1 CRP ACE
29 acute myocardial infarction 29.7 TNNI3 PIK3C2A EDN1 CRP ACE
30 peripheral vascular disease 29.6 NOS3 KNG1 HTR2A CRP ACE
31 cardiac arrest 29.5 PIK3C2A KNG1 KCNJ8 ACE
32 ischemia 29.5 PIK3C2A NOS3 KNG1 EDN1 ACE
33 vascular disease 29.4 NOS3 KNG1 HTR2A EDN1 CRP AHSP
34 pulmonary edema 29.4 TNNI3 PIK3C2A NOS3 EDN1 CRP ACE
35 coronary artery anomaly 29.2 TNNI3 PIK3C2A NOS3 KNG1 EDN1 CRP
36 dilated cardiomyopathy 29.1 TNNI3 NOS3 KNG1 EDN1 CRP ADRA2C
37 heart disease 29.0 TNNI3 PIK3C2A NOS3 KNG1 EDN1 CRP
38 attention deficit-hyperactivity disorder 28.7 HTR2A ADRA2C ADRA2B ADRA2A ADRA1A
39 diabetes mellitus 28.3 PIK3C2A NOS3 KNG1 EDN1 CRP AOC3
40 congestive heart failure 28.0 TNNI3 PIK3C2A NOS3 KNG1 EDN1 CRP
41 myocardial infarction 27.9 TNNI3 PIK3C2A NOS3 KNG1 HTR2A EDN1
42 hypertension, essential 24.7 TNNI3 ROCK1 RHOA PPP1R12A PIK3C2A NOS3
43 coronary thrombosis 10.5
44 chronic thromboembolic pulmonary hypertension 10.4 EDN1 CRP
45 mediastinum teratoma 10.4 CRP ACE
46 acute dacryoadenitis 10.4 CRP ACE
47 diabetic angiopathy 10.4 NOS3 EDN1 AOC3
48 hyperlipoproteinemia, type iii 10.4
49 dressler's syndrome 10.4 CRP AHSP
50 rheumatic myocarditis 10.4 TNNI3 CRP

Graphical network of the top 20 diseases related to Coronary Artery Vasospasm:



Diseases related to Coronary Artery Vasospasm

Symptoms & Phenotypes for Coronary Artery Vasospasm

UMLS symptoms related to Coronary Artery Vasospasm:


angina pectoris

MGI Mouse Phenotypes related to Coronary Artery Vasospasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ACE ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C
2 behavior/neurological MP:0005386 10.11 ACE ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C
3 homeostasis/metabolism MP:0005376 10.07 ACE ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C
4 mortality/aging MP:0010768 10 ACE ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C
5 muscle MP:0005369 9.65 ADRA1A ADRA1B ADRA2B EDN1 HTR2A KCNJ8
6 renal/urinary system MP:0005367 9.32 ACE ADRA1A ADRA1B ADRA2B EDN1 NOS3

Drugs & Therapeutics for Coronary Artery Vasospasm

Drugs for Coronary Artery Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diltiazem Approved, Investigational Phase 4 42399-41-7 39186
2
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
3
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
4
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
5
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
6
Bisoprolol Approved Phase 4 66722-44-9 2405
7
Ramipril Approved Phase 4 87333-19-5 5362129
8
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
9
Atorvastatin Approved Phase 4 134523-00-5 60823
10
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
11
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
12
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
13 Tocotrienol Investigational Phase 4 6829-55-6
14 Antihypertensive Agents Phase 4
15 Neurotransmitter Agents Phase 4
16 Adrenergic Agonists Phase 4
17 Adrenergic beta-Agonists Phase 4
18 Adrenergic Agents Phase 4
19 Natriuretic Agents Phase 4
20 Adrenergic beta-Antagonists Phase 4
21 Mineralocorticoid Receptor Antagonists Phase 4
22 diuretics Phase 4
23 Angiotensin-Converting Enzyme Inhibitors Phase 4
24 HIV Protease Inhibitors Phase 4
25
protease inhibitors Phase 4
26 Adrenergic Antagonists Phase 4
27 Hormone Antagonists Phase 4
28 Mineralocorticoids Phase 4
29 Sodium Channel Blockers Phase 4
30 Adrenergic beta-1 Receptor Antagonists Phase 4
31 Autonomic Agents Phase 4
32 Diuretics, Potassium Sparing Phase 4
33 Sodium Potassium Chloride Symporter Inhibitors Phase 4
34 Sympatholytics Phase 4
35 Antimetabolites Phase 4
36 calcium channel blockers Phase 4
37 Calcium, Dietary Phase 4
38 Hormones Phase 4
39 Micronutrients Phase 4
40 Vitamins Phase 4
41 Trace Elements Phase 4
42 Anticholesteremic Agents Phase 4
43 Hypolipidemic Agents Phase 4
44 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
45 Tocopherols Phase 4
46 Antioxidants Phase 4
47 Nutrients Phase 4
48 Tocotrienols Phase 4
49 Protective Agents Phase 4
50 Lipid Regulating Agents Phase 4

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm Completed NCT03930433 Phase 4 Nebivolol;Diltiazem;Nebivolol+Diltiazem
2 Resistant Hypertension On Treatment - Sequential Nephron Blockade Compared to Dual Blockade of the Renin-angiotensin-aldosterone System Plus Bisoprolol in the Treatment of Resistant Arterial Hypertension: A Randomized Trial (ResHypOT) Completed NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
3 Effects of Long-term Vitamin C+E and Statin Therapy on Vasospasm Improvement and Regression of Atheroma in Patients With Variant Angina Recruiting NCT03228238 Phase 4 Vitamin C and Vitamin E;Statin;Standard medication for variant angina
4 Calcium Administration in Patients Undergoing Cardiac Surgery Under Cardiopulmonary Bypass (ICARUS Trial): Prospective Randomized, Double-blind Placebo-controlled Superiority Trial Recruiting NCT03772990 Phase 4 Calcium Chloride;0.9% Sodium Chloride
5 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans AIM III Completed NCT01067339 Phase 3 darapladib;placebo
6 Application of Sildenafil in Patients With Documented Coronary Vasospasm to Explore the Pathophysiology of Coronary Vasospasm and the Therapeutic Effect of Sildenafil in Patients Suffering From Coronary Vasospasm Withdrawn NCT00454714 Phase 3 single dose Sildenafil;Single dose placebo
7 Toxicity OF Fluoropyrimidines: A Comparative Study of the Cardiotoxicity of capEcitabine and tEysuno Unknown status NCT01845337 Phase 2 Teysuno;Capecitabine
8 Assessment of Coronary Plaque Composition Using Near Infrared Spectroscopy During Inhibition of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity Completed NCT01581632 Phase 1
9 Clinical Observation of CHD Phlegm and Blood-stasis Syndrome Patients Unknown status NCT02967718
10 Panic Disorder and Cardiac Risk: Evaluation of a Psychological Treatment Which Addresses Biology, Psychology and Behaviour Unknown status NCT00168506 SSRI;CBT;CBT/SSRI
11 Correlation Between Abnormal Coronary Vasoreactivity Testing, Expansion of CD4+CD28null T Cells and Biomarkers for Inflammation and Endothelial Dysfunction in Patients With Angina Despite Angiographically Normal Coronary Arteries. Unknown status NCT01162824 Acetylcholine;Adenosine
12 The Use of Cardiovascular Biomarkers in Abdominal Aortic Surgery: Possibility of Risk Assessment and Stratification Unknown status NCT02122497
13 Digital Tonometry for Measurement of Peripheral Artery Reactive Hyperemia as Non-invasive Test for Diagnosis of Coronary Artery Spasm Completed NCT00619294
14 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level Completed NCT01877993
15 The Association of Acetylcholine-induced Coronary Artery Spasm With the Blood Pressure Level in Hypertensive Patients Treated With Blood Pressure Lowering Drugs Completed NCT01882790
16 The Multicenter Registry to Evaluate the Natural Course of Coronary Spasm Patients Presenting Aborted Sudden Cardiac Death Completed NCT02298543
17 "Reversibility of Cardiovascular Injury With Continuous Positive Airway Pressure (CPAP) Use: Mechanisms Involved" Completed NCT01317329
18 Influence of Plasma Glucose Levels on Retinal Vascular Diameter and Choroidal Blood Flow in Vasospastic Subjects Completed NCT00350129
19 Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans Completed NCT01557088
20 The Clinical Efficacy Comparison of Two Renal Sympathetic Denervation Strategies ---- Full Length Versus Proximal Renal Arteries Ablation Completed NCT01848275
21 Observational Study of the Polymorphisms of the Renin-angiotensin-aldosterone System and Their Relation to Resistant Systemic Arterial Hypertension and Adverse Cardiovascular Events Completed NCT01173029 Anti-hypertensive drug treatment
22 The Evaluation of the Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG Imaging Completed NCT01432626 I-123 radiolabeled metaiodobenzylguanidine cardiac imaging
23 Computed Tomography Angiography Prediction Score for Side Branch Occlusion in Coronary Bifurcation Intervention (CT-PRECISION) Recruiting NCT03709836
24 NYU Takotsubo (Broken Heart Syndrome) Registry Recruiting NCT03663348
25 Dual-acquisition of Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry Recruiting NCT03570671
26 Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries Recruiting NCT00921856
27 Angina in Patients Without Obstructive Coronary Disease as Revealed by CT Coronary Angiography (Cor-CTCA): an Observational Cohort Study Involving Coronary Function Tests and a Nested Randomised Trial Recruiting NCT03477890
28 CORonary MICrovascular Angina (CorMicA): a Randomised, Controlled, Pilot Trial Active, not recruiting NCT03193294
29 Canadian Spontaneous Coronary Artery Dissection (SCAD) Cohort Study Active, not recruiting NCT02188069

Search NIH Clinical Center for Coronary Artery Vasospasm

Cochrane evidence based reviews: coronary vasospasm

Genetic Tests for Coronary Artery Vasospasm

Genetic tests related to Coronary Artery Vasospasm:

# Genetic test Affiliating Genes
1 Coronary Artery Spasm 29

Anatomical Context for Coronary Artery Vasospasm

MalaCards organs/tissues related to Coronary Artery Vasospasm:

40
Heart, Testes, Endothelial, T Cells, Smooth Muscle, Kidney, Monocytes

Publications for Coronary Artery Vasospasm

Articles related to Coronary Artery Vasospasm:

(show top 50) (show all 1298)
# Title Authors PMID Year
1
Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction. 54 61
19623039 2009
2
Association of endothelin-1 gene polymorphisms with variant angina in Korean patients. 54 61
19012521 2008
3
Update on evidence for a genetic predisposition to cerebral vasospasm. 54 61
17029342 2006
4
Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. 54 61
16820593 2006
5
Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene. 54 61
16565556 2006
6
Genetic variations in vascular endothelial growth factor and endothelial nitric oxide synthase and their contributions to human disease. 54 61
15825252 2005
7
[Cardioprotective effects of diltiazem infusion in the perioperative period in patients undergoing coronary artery bypass grafting with extracorporeal circulation]. 54 61
14521738 2003
8
Interplanetary travel and permanent injury to normal heart. 54 61
11543600 1997
9
5-HT receptors mediating contractions of the isolated human coronary artery. 54 61
7693489 1993
10
Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry). 61
31185091 2020
11
Computed Tomographic Angiography-Verified Myocardial Bridge and Invasive Angiography-Verified Left Anterior Descending Coronary Artery Vasospasm. 61
31548153 2020
12
Acute Myocardial Infarction in Young Individuals. 61
31902409 2020
13
Management of Angina Post Percutaneous Coronary Intervention. 61
31965355 2020
14
Coronary vasospasm induced by cisplatin for seminoma. 61
31998514 2020
15
Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon. 61
31856732 2019
16
Kounis syndrome uncovers severe coronary disease: an unusual case of acute coronary syndrome secondary to allergic coronary vasospasm. 61
31874849 2019
17
Fluoropyrimidine-Associated Cardiotoxicity: A Retrospective Case-Control Study. 61
31843972 2019
18
Coronary artery vasospasm after misoprostol treatment for incomplete abortion: a case report. 61
31446021 2019
19
Risk of vasopressin use: a case of acute pulmonary oedema, post intramyometrial infiltration of vasopressin in laparoscopic myomectomy. 61
31831516 2019
20
Coronary vasospasm caused by intravenous infusion of dexmedetomidine: Unrecognized pitfall of catheter ablation procedures of atrial fibrillation. 61
31762838 2019
21
Ventricular fibrillation in a patient with Wolff-Parkinson-White syndrome unrelated to pre-excited atrial fibrillation. 61
31141244 2019
22
Ventricular Fibrillation Cardiac Arrest in Young Female from Diffuse Left Anterior Descending Coronary Vasospasm. 61
31763597 2019
23
Fluoropyrimidine-Associated Cardiotoxicity. 61
31587781 2019
24
Diagnosis of malignant coronary vasospasm by 12-lead Holter electrocardiogram and optical coherence tomography. 61
31638699 2019
25
Coronary artery dissection due to severe coronary vasospasm during ergonovine provocation test. 61
31658136 2019
26
[Coronary vasospasm in a child allergic to latex: Kounis syndrome]. 61
31560503 2019
27
Coronary vasospasm: An infrequent cause of cardiopulmonary arrest. 61
31615714 2019
28
Successful 5-fluorouracil (5-FU) infusion re-challenge in a metastatic colorectal cancer patient with coronary artery disease who experienced symptoms consistent with coronary vasospasm during first 5-FU infusion. 61
31602339 2019
29
Acute inferior ST-elevation myocardial infarction due to delirium tremens: a case report. 61
31597573 2019
30
Under-diagnosis of Takotsubo Cardiomyopathy Increases Risk of Adverse Events: A Case Study. 61
31723510 2019
31
A case series: alternative access for refractory shock during cardiac arrest. 61
31660478 2019
32
Vancomycin-induced Kounis Syndrome. 61
31182359 2019
33
An unusual complication during alcohol septal ablation: severe left anterior descending artery vasospasm causing cardiac arrest: a case report and review of the literature. 61
31425578 2019
34
The Novel Inodilator ORM-3819 Relaxes Isolated Porcine Coronary Arteries: Role of Voltage-Gated Potassium Channel Activation. 61
31356552 2019
35
5-Fluorouracil-Associated Coronary Vasospasm in a Patient With Metastatic Adenocarcinoma of the Esophagus. 61
31206361 2019
36
Case report: assessment and management of myocardial infarction and non-obstructive coronary arteries (MINOCA): the role of microvascular coronary vasospasm. 61
31555546 2019
37
Non-infarctual ST elevation and acute cardiopulmonary failure in carbon monoxide poisoning: a case report. 61
31486515 2019
38
Non-ST-Elevation Myocardial Infarction-Like Syndrome in Scombroid Tuna Fish Poisoning. 61
31221463 2019
39
Phentermine and Coronary Vasospasm-Induced Myocardial Infarction. 61
31272579 2019
40
Acute ST-Segment Elevation Myocardial Infarction Following Intramuscular Diclofenac: A Case of Kounis Syndrome. 61
31014971 2019
41
Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease? 61
30227459 2019
42
Kounis Syndrome—not a Single-organ Arterial Disorder but a Multisystem and Multidisciplinary Disease 61
31198019 2019
43
ST elevation in recovery post exercise with normal coronary arteries. 61
31289167 2019
44
Coronary Vasospasm Induced by Phentermine. 61
31272562 2019
45
Spontaneous coronary vasospasm due to polytrauma. 61
31049387 2019
46
Prevalence of Coronary Vasospasm Using Coronary Reactivity Testing in Patients With Spontaneous Coronary Artery Dissection. 61
30948002 2019
47
Marijuana-induced Coronary Vasospasm with Persistent Inter-coronary Connection: A Case Report and Review of Literature. 61
31497413 2019
48
Phase I/II study of everolimus combined with mFOLFOX-6 and bevacizumab for first-line treatment of metastatic colorectal cancer. 61
30302599 2019
49
Myocardial infarction with non-obstructive coronary arteries: a focus on vasospastic angina. 61
30689112 2019
50
Coronary Artery Vasospasm Induced by 5-fluorouracil: Proposed Mechanisms, Existing Management Options and Future Directions. 61
31178935 2019

Variations for Coronary Artery Vasospasm

Expression for Coronary Artery Vasospasm

Search GEO for disease gene expression data for Coronary Artery Vasospasm.

Pathways for Coronary Artery Vasospasm

Pathways related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 KNG1 HTR2A EDN1 ADRA2C ADRA2B ADRA2A
2
Show member pathways
13.36 TNNI3 ROCK1 RHOA PPP1R12A NOS3 CRP
3
Show member pathways
12.83 ROCK1 RHOA PPP1R12A PIK3C2A NOS3 ADRA2A
4
Show member pathways
12.69 ROCK1 RHOA EDN1 ADRA2B ADRA2A ADRA1B
5 12.53 ROCK1 RHOA PPP1R12A PIK3C2A KNG1
6
Show member pathways
12.26 ROCK1 RHOA PPP1R12A NOS3 EDN1 ADRA1B
7 12.19 TNNI3 ROCK1 RHOA PPP1R12A EDN1
8
Show member pathways
12.17 NOS3 HTR2A ADRA1B ADRA1A
9
Show member pathways
12.03 NOS3 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
10
Show member pathways
11.9 TNNI3 ROCK1 RHOA PPP1R12A NOS3 KNG1
11 11.89 ROCK1 RHOA PPP1R12A NOS3
12 11.85 ROCK1 RHOA NOS3 KNG1
13
Show member pathways
11.78 ADRA2C ADRA2B ADRA2A
14
Show member pathways
11.74 ROCK1 RHOA NOS3
15
Show member pathways
11.67 NOS3 KNG1 ACE
16
Show member pathways
11.67 HTR2A ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
17 11.58 ROCK1 RHOA NOS3
18 11.42 ROCK1 RHOA KNG1
19 11.39 ROCK1 RHOA PIK3C2A
20 11.37 ROCK1 RHOA NOS3
21 11.31 ROCK1 RHOA PPP1R12A
22 11.22 NOS3 EDN1 ADRA1A
23 10.72 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A

GO Terms for Coronary Artery Vasospasm

Cellular components related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.03 TNNI3 ROCK1 RHOA PPP1R12A PIK3C2A NOS3
2 cell GO:0005623 9.87 TNNI3 NOS3 KNG1 HTR2A EDN1 ADRA1B
3 plasma membrane GO:0005886 9.5 ROCK1 RHOA PPP1R12A PIK3C2A NOS3 KNG1
4 integral component of postsynaptic membrane GO:0099055 9.43 HTR2A ADRA2C ADRA1A
5 contractile fiber GO:0043292 9.37 TNNI3 PPP1R12A
6 caveola GO:0005901 9.26 NOS3 HTR2A ADRA1B ADRA1A

Biological processes related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.18 ROCK1 RHOA KNG1 HTR2A EDN1 ADRA2C
2 cell-cell signaling GO:0007267 9.97 EDN1 ADRA2C ADRA2B ADRA1B ADRA1A
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.93 KNG1 HTR2A EDN1 ADRA1B ADRA1A
4 positive regulation of neuron differentiation GO:0045666 9.83 RHOA ADRA2C ADRA2B
5 Rho protein signal transduction GO:0007266 9.82 ROCK1 RHOA ADRA2A
6 regulation of blood pressure GO:0008217 9.8 NOS3 EDN1 ACE
7 positive regulation of MAPK cascade GO:0043410 9.8 ROCK1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
8 positive regulation of MAP kinase activity GO:0043406 9.79 HTR2A EDN1 ADRA2A
9 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.79 HTR2A ADRA1B ADRA1A
10 activation of protein kinase B activity GO:0032148 9.77 ADRA2C ADRA2B ADRA2A
11 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.77 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
12 phosphatidylinositol 3-kinase signaling GO:0014065 9.76 PIK3C2A HTR2A EDN1
13 positive regulation of cardiac muscle hypertrophy GO:0010613 9.75 ROCK1 EDN1 ADRA1A
14 regulation of blood vessel diameter GO:0097746 9.73 ROCK1 NOS3 ACE
15 positive regulation of smooth muscle contraction GO:0045987 9.73 RHOA EDN1 ADRA1B ADRA1A
16 regulation of muscle contraction GO:0006937 9.72 TNNI3 ADRA1B ADRA1A
17 regulation of smooth muscle contraction GO:0006940 9.71 TNNI3 ADRA2C ADRA2B ADRA2A
18 negative regulation of norepinephrine secretion GO:0010700 9.7 ADRA2C ADRA2B ADRA2A
19 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.69 RHOA NOS3 EDN1
20 heart contraction GO:0060047 9.67 TNNI3 ACE
21 receptor transactivation GO:0035624 9.67 ADRA2C ADRA2B ADRA2A
22 negative regulation of calcium ion transport GO:0051926 9.66 NOS3 ADRA2A
23 negative regulation of blood coagulation GO:0030195 9.66 KNG1 EDN1
24 response to transforming growth factor beta GO:0071559 9.65 ROCK1 EDN1
25 positive regulation of vasoconstriction GO:0045907 9.65 RHOA HTR2A ADRA2C ADRA1B ADRA1A
26 negative regulation of potassium ion transport GO:0043267 9.64 NOS3 HTR2A
27 artery smooth muscle contraction GO:0014824 9.64 HTR2A EDN1
28 positive regulation of systemic arterial blood pressure GO:0003084 9.63 ADRA1A ACE
29 negative regulation of biomineral tissue development GO:0070168 9.63 ROCK1 NOS3
30 negative regulation of epinephrine secretion GO:0032811 9.63 ADRA2C ADRA2B ADRA2A
31 regulation of establishment of endothelial barrier GO:1903140 9.61 ROCK1 PPP1R12A
32 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 9.6 ADRA1B ADRA1A
33 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.55 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
34 adrenergic receptor signaling pathway GO:0071875 9.35 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A
35 regulation of vasoconstriction GO:0019229 9.17 EDN1 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A

Molecular functions related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.72 AOC3 ADRA2C ADRA2A ADRA1B ADRA1A
2 epinephrine binding GO:0051379 9.33 ADRA2C ADRA2B ADRA2A
3 alpha1-adrenergic receptor activity GO:0004937 9.26 ADRA1B ADRA1A
4 alpha2-adrenergic receptor activity GO:0004938 9.13 ADRA2C ADRA2B ADRA2A
5 adrenergic receptor activity GO:0004935 9.02 ADRA2C ADRA2B ADRA2A ADRA1B ADRA1A

Sources for Coronary Artery Vasospasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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