CHD
MCID: CRN300
MIFTS: 59

Coronary Heart Disease 1 (CHD)

Categories: Genetic diseases

Aliases & Classifications for Coronary Heart Disease 1

MalaCards integrated aliases for Coronary Heart Disease 1:

Name: Coronary Heart Disease 1 57 29
Coronary Heart Disease 57 76 29 55 6 63 73
Coronary Heart Disease, Susceptibility to, 1 57 73
Heart, Coronary, Disease, Susceptibility to, Type 1 40
Coronary Heart Disease, Susceptibility to 57
Coronary Arteriosclerosis 73
Coronary Artery Disease 73
Chds1 57
Chd 48

Classifications:



External Ids:

OMIM 57 607339

Summaries for Coronary Heart Disease 1

PubMed Health : 63 About coronary heart disease: Coronary heart disease (CHD) is a disease in which a waxy substance called plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle.When plaque builds up in the arteries, the condition is called atherosclerosis (ATH-er-o-skler-O-sis). The buildup of plaque occurs over many years.

MalaCards based summary : Coronary Heart Disease 1, also known as coronary heart disease, is related to diabetes mellitus, noninsulin-dependent and lung cancer, and has symptoms including tremor, angina pectoris and edema. An important gene associated with Coronary Heart Disease 1 is APOC3 (Apolipoprotein C3), and among its related pathways/superpathways is MicroRNAs in cancer. Affiliated tissues include heart, endothelial and testes.

Wikipedia : 76 Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the most common of the... more...

Description from OMIM: 607339

Related Diseases for Coronary Heart Disease 1

Diseases in the Coronary Heart Disease 5 family:

Coronary Heart Disease 3 Coronary Heart Disease 1
Coronary Heart Disease 2 Coronary Heart Disease 4
Coronary Heart Disease 7 Coronary Heart Disease 8
Coronary Heart Disease 9 Coronary Heart Disease 6

Diseases related to Coronary Heart Disease 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, noninsulin-dependent 31.3 APOC3 CDKN2B-AS1 GAS5 MIR126 SOCS1 WFDC21P
2 lung cancer 30.4 CDKN2A CDKN2B CDKN2B-AS1 GAS5 H19 HOTTIP
3 gastric cancer 30.2 CDKN2A CDKN2B CDKN2B-AS1 GAS5 H19 HOTTIP
4 colorectal cancer 30.1 CDKN2A CDKN2B-AS1 GAS5 H19 HOTTIP MIR126
5 esophageal cancer 30.0 CDKN2A CDKN2B CDKN2B-AS1 GAS5 H19 HOTTIP
6 ovarian cancer 30.0 CDKN2B CDKN2B-AS1 GAS5 H19 MIR126 MIR145
7 coronary artery anomaly 12.0
8 coronary heart disease 2 11.6
9 coronary heart disease 4 11.6
10 coronary heart disease 5 11.6
11 hyperlipidemia, familial combined 11.5
12 heart disease 11.5
13 coronary heart disease 3 11.5
14 coronary heart disease 7 11.5
15 coronary heart disease 8 11.5
16 coronary heart disease 9 11.5
17 coronary heart disease 6 11.5
18 angina pectoris 11.4
19 hypercholesterolemia, familial 11.4
20 abdominal obesity-metabolic syndrome 1 11.3
21 cardiac arrest 11.3
22 hyperlipoproteinemia, type iii 11.2
23 high density lipoprotein cholesterol level quantitative trait locus 1 11.2
24 total anomalous pulmonary venous return 1 11.1
25 hyperlipidemia, combined, 1 11.0
26 hypoalphalipoproteinemia, primary 11.0
27 8p23.1 duplication syndrome 11.0
28 congenitally corrected transposition of the great arteries 11.0
29 diabetes mellitus 10.7
30 depression 10.6
31 myocardial infarction 10.6
32 anxiety 10.4
33 ischemia 10.4
34 chlamydia 10.4
35 melanoma-pancreatic cancer syndrome 10.4 CDKN2A CDKN2B-AS1
36 pancreatic ductal adenocarcinoma 10.4 H19 HOTTIP MIR145 MIR155
37 endometriosis 10.3 CDKN2B-AS1 H19 MIR126 MIR145
38 malignant glioma 10.3 CDKN2B-AS1 GAS5 HOTTIP
39 thyroid cancer, nonmedullary, 1 10.3 GAS5 H19 HOTTIP MIR155
40 kidney cancer 10.3 GAS5 H19 MIR126 MIR17 MIR182
41 prostate disease 10.3 CDKN2B-AS1 GAS5 H19 IGF2-AS
42 laryngeal squamous cell carcinoma 10.3 CDKN2A CDKN2B-AS1 H19
43 osteogenic sarcoma 10.3 CDKN2B-AS1 GAS5 H19 HOTTIP
44 chlamydia pneumonia 10.3
45 nervous system cancer 10.3 CDKN2A CDKN2B CDKN2B-AS1
46 tenosynovial giant cell tumor 10.3 CDKN2A CDKN2B
47 adamantinoma of long bones 10.3 CDKN2A CDKN2B-AS1 GAS5 H19 HOTTIP
48 acute lymphocytic leukemia 10.3 CDKN2A CDKN2B CDKN2B-AS1
49 leukemia, acute myeloid 10.3 CDKN2B CDKN2B-AS1 MIR126 MIR155 MIR182
50 scrotal carcinoma 10.3 CDKN2A CDKN2B

Graphical network of the top 20 diseases related to Coronary Heart Disease 1:



Diseases related to Coronary Heart Disease 1

Symptoms & Phenotypes for Coronary Heart Disease 1

Clinical features from OMIM:

607339

UMLS symptoms related to Coronary Heart Disease 1:


tremor, angina pectoris, edema, chest pain, equilibration disorder, substernal pain

Drugs & Therapeutics for Coronary Heart Disease 1

PubMedHealth treatment related to Coronary Heart Disease 1: 63

Treatments for coronary heart disease (CHD) include lifestyle changes, medicines, and medical procedures. Treatment goals may include:Relieving symptoms.Reducing risk factors in an effort to slow, stop, or reverse the buildup of plaque.Lowering the risk of blood clots forming. (Blood clots can cause a heart attack.)Widening or bypassing clogged arteries.Preventing complications of CHD.

Search Clinical Trials , NIH Clinical Center for Coronary Heart Disease 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Coronary Heart Disease 1

Genetic tests related to Coronary Heart Disease 1:

# Genetic test Affiliating Genes
1 Coronary Heart Disease 1 29 CX3CR1
2 Coronary Heart Disease 29

Anatomical Context for Coronary Heart Disease 1

MalaCards organs/tissues related to Coronary Heart Disease 1:

41
Heart, Endothelial, Testes, Liver, Breast, Bone, Kidney

Publications for Coronary Heart Disease 1

Articles related to Coronary Heart Disease 1:

(show top 50) (show all 3166)
# Title Authors Year
1
Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease. ( 30270499 )
2019
2
Self-reported myocardial infarction and fatal coronary heart disease among oil spill workers and community members 5 years after Deepwater Horizon. ( 30278364 )
2019
3
Dietary patterns, bone lead and incident coronary heart disease among middle-aged to elderly men. ( 30317107 )
2019
4
Low skeletal muscle mass is associated with low aerobic capacity and increased mortality risk in patients with coronary heart disease - a CARE CR study. ( 30168241 )
2019
5
Risk of heart failure in a population with type 2 diabetes versus a population without diabetes with and without coronary heart disease. ( 30091215 )
2019
6
Depressive Symptoms in Women With Coronary Heart Disease: A Systematic Review of the Longitudinal Literature. ( 30138156 )
2019
7
Human cytomegalovirus infection and coronary heart disease: a systematic review. ( 29409508 )
2018
8
The association of neck circumference with incident congestive heart failure and coronary heart disease mortality in a community-based population with or without sleep-disordered breathing. ( 29855261 )
2018
9
Fine particulate matter and incident coronary heart disease in the REGARDS cohort. ( 29447790 )
2018
10
A study on the relationship between plasma selenium concentration and erythrocyte deformability in rat models of coronary heart disease. ( 29442482 )
2018
11
Adiposity-Mortality Relationships in Type 2 Diabetes, Coronary Heart Disease and Cancer Subgroups in the UK Biobank, and Their Modification by Smoking. ( 29970414 )
2018
12
Suicidal ideation in patients with coronary heart disease and hypertension: Baseline results from the DEPSCREEN-INFO clinical trial. ( 29971880 )
2018
13
National Prevalence of Self-Reported Coronary Heart Disease and Chronic Stable Angina Pectoris: Factor Analysis of the Underlying Cardiometabolic Risk Factors in the Fourth Round of the SuRFNCD-2011. ( 29434010 )
2018
14
Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism. ( 29357324 )
2018
15
PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease. ( 29441810 )
2018
16
The AUStralian MEDiterranean Diet Heart Trial (AUSMED Heart Trial): A randomized clinical trial in secondary prevention of coronary heart disease in a multiethnic Australian population: Study protocol. ( 29966802 )
2018
17
ENPP1 K121Q (rs1044498a88Ca88>a88A) genetic polymorphism confers a high risk of susceptibility to coronary heart disease: A PRISMA-compliant article. ( 29979387 )
2018
18
The association of inflammatory markers and periodontal indexes with the risk of coronary heart disease in Chinese patients with type 2 diabetes mellitus. ( 29111278 )
2018
19
A Literature Review of Antithrombotic Therapy for Patients of Venous Thromboembolic Events with Comorbidity of Coronary Heart Disease. ( 29976282 )
2018
20
'Heart disease never entered my head' Women's Understanding of Coronary Heart Disease Risk Factors. ( 29969829 )
2018
21
Corrigendum to 'Effects of RG7652, a Monoclonal Antibody Against PCSK9, on Low-Density Lipoprotein Cholesterol (LDL-C), LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or with Established Coronary Heart Disease (From the Phase 2 EQUATOR Study)' The American Journal of Cardiology 119 (2017) 1576-1583. ( 29448977 )
2018
22
Prevalence of lipid abnormalities and cholesterol target value attainment in patients with stable coronary heart disease or an acute coronary syndrome in Saudi Arabia. ( 29968891 )
2018
23
Peripheral vascular disease risk in diabetic individuals without coronary heart disease. ( 29801688 )
2018
24
Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: Results from two independent cohorts. ( 29728335 )
2018
25
Left Ventricular Ejection Fraction Predicts Poststroke Cardiovascular Events and Mortality in Patients without Atrial Fibrillation and Coronary Heart Disease. ( 30403019 )
2018
26
Comparison of Frequency of Ischemic Stroke in Patients With Versus Without Coronary Heart Disease and Without Atrial Fibrillation. ( 30389089 )
2018
27
Improved survival of hospitalized patients with cardiac arrest due to coronary heart disease after implementation of post-cardiac arrest care: A population-based study. ( 30213003 )
2018
28
Two-year effectiveness of a stepped-care depression prevention intervention and predictors of incident depression in primary care patients with diabetes type 2 and/or coronary heart disease and subthreshold depression: data from the Step-Dep cluster randomised controlled trial. ( 30373778 )
2018
29
Effectiveness and safety of modified 'Huoxue Shugan' formulas on coronary heart disease combined with depression: protocol for a systematic review. ( 30391917 )
2018
30
Type 2 Diabetes Mellitus is Associated with Carotid Artery Plaques in Patients with Premature Coronary Heart Disease. ( 30532096 )
2018
31
Heart Failure Epidemiology in Patients With Diabetes Mellitus Without Coronary Heart Disease. ( 30423457 )
2018
32
Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study. ( 30195754 )
2018
33
The Association between Plasma Levels of Trimethylamine N-Oxide and the Risk of Coronary Heart Disease in Chinese Patients with or without Type 2 Diabetes Mellitus. ( 30159101 )
2018
34
Serum bilirubin concentrations, type 2 diabetes and incident coronary heart disease. ( 30467728 )
2018
35
Assessment of Intermingled Phlegm and Blood Stasis Syndrome in Coronary Heart Disease: Development of a Diagnostic Scale. ( 30473717 )
2018
36
Serum alkaline phosphatase and the risk of coronary heart disease, stroke and all-cause mortality: Tehran Lipid and Glucose Study. ( 30478120 )
2018
37
Classical Chinese Herbal Formulas in the Treatment of Coronary Heart Disease: A Narrative Review. ( 30484017 )
2018
38
The effect of acetylsalicylic acid dosed at bedtime on the anti-aggregation effect in patients with coronary heart disease and arterial hypertension: A randomized, controlled trial. ( 30484269 )
2018
39
Low cigarette consumption and risk of coronary heart disease and stroke: a meta-analysis of 141 cohort studies within 55 study reports. ( 30487298 )
2018
40
Peak oxygen uptake and incident coronary heart disease in a healthy population: the HUNT Fitness Study. ( 30496487 )
2018
41
Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study. ( 30496985 )
2018
42
Association between TNF-α polymorphisms and the risk of upper gastrointestinal bleeding induced by aspirin in patients with coronary heart disease. ( 30506894 )
2018
43
Re-examining the relationship between alcohol consumption and coronary heart disease with a new lens. ( 30508551 )
2018
44
Role of SH2B3 R262W gene polymorphism and risk of coronary heart disease: A PRISMA-compliant meta-analysis. ( 30508957 )
2018
45
The tooth loss and mortality from all causes, cardiovascular diseases and coronary heart disease: Systematic review and dose-response meta-analysis. ( 30530864 )
2018
46
Understanding the Multitarget Pharmacological Mechanism of the Traditional Mongolian Common Herb Pair GuangZao-RouDouKou Acting on Coronary Heart Disease Based on a Bioinformatics Approach. ( 30534179 )
2018
47
The Association of Fasting Glucose, Insulin, and C-Peptide, with 19-Year Incidence of Coronary Heart Disease in Older Japanese-American Men; the Honolulu Heart Program. ( 30555835 )
2018
48
Emerging Applications of Coronary CT Angiography in Coronary Heart Disease: Getting Better with Time. ( 30383272 )
2018
49
Selected psychological comorbidities in coronary heart disease: Challenges and grand opportunities. ( 30394780 )
2018
50
Effect of age-related baseline risk on radiation dose response for coronary heart disease. ( 30398167 )
2018

Variations for Coronary Heart Disease 1

ClinVar genetic disease variations for Coronary Heart Disease 1:

6 (show all 16)
# Gene Variation Type Significance SNP ID Assembly Location
1 LPL NM_000237.2(LPL): c.106G> A (p.Asp36Asn) single nucleotide variant Likely benign rs1801177 GRCh37 Chromosome 8, 19805708: 19805708
2 LPL NM_000237.2(LPL): c.106G> A (p.Asp36Asn) single nucleotide variant Likely benign rs1801177 GRCh38 Chromosome 8, 19948197: 19948197
3 APOC3 NM_000040.2(APOC3): c.55C> T (p.Arg19Ter) single nucleotide variant Pathogenic rs76353203 GRCh37 Chromosome 11, 116701353: 116701353
4 APOC3 NM_000040.2(APOC3): c.55C> T (p.Arg19Ter) single nucleotide variant Pathogenic rs76353203 GRCh38 Chromosome 11, 116830637: 116830637
5 APOC3 NM_000040.2(APOC3): c.55+1G> A single nucleotide variant Pathogenic,protective rs138326449 GRCh38 Chromosome 11, 116830638: 116830638
6 APOC3 NM_000040.2(APOC3): c.55+1G> A single nucleotide variant Pathogenic,protective rs138326449 GRCh37 Chromosome 11, 116701354: 116701354
7 APOC3 NM_000040.2(APOC3): c.127G> A (p.Ala43Thr) single nucleotide variant Pathogenic,protective rs147210663 GRCh38 Chromosome 11, 116830844: 116830844
8 APOC3 NM_000040.2(APOC3): c.127G> A (p.Ala43Thr) single nucleotide variant Pathogenic,protective rs147210663 GRCh37 Chromosome 11, 116701560: 116701560
9 APOC3 NM_000040.2(APOC3): c.179+1G> T single nucleotide variant Pathogenic,protective rs140621530 GRCh38 Chromosome 11, 116830897: 116830897
10 APOC3 NM_000040.2(APOC3): c.179+1G> T single nucleotide variant Pathogenic,protective rs140621530 GRCh37 Chromosome 11, 116701613: 116701613
11 PRKAG2 NM_016203.3(PRKAG2): c.590C> G (p.Pro197Arg) single nucleotide variant Uncertain significance rs368637364 GRCh38 Chromosome 7, 151675514: 151675514
12 PRKAG2 NM_016203.3(PRKAG2): c.590C> G (p.Pro197Arg) single nucleotide variant Uncertain significance rs368637364 GRCh37 Chromosome 7, 151372600: 151372600
13 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh37 Chromosome 4, 11408585: 11408585
14 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh38 Chromosome 4, 11406961: 11406961
15 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 17, 80363699: 80363699
16 RNF213 NM_001256071.2(RNF213): c.11659A> G (p.Lys3887Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 17, 78337499: 78337499

Copy number variations for Coronary Heart Disease 1 from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21785 1 161475204 161643863 Copy number FCGR2A Coronary artery disease
2 71425 12 69818942 132349534 Copy number Coronary artery disease
3 112708 17 40930407 78774742 Copy number Coronary artery disease
4 139335 2 179004449 242951149 Copy number Coronary artery disease
5 195353 5 150157836 180857866 Copy number Coronary artery disease
6 195373 5 150183562 180857866 Copy number Coronary artery disease
7 207392 6 155500000 161000000 Gain or loss LPA Coronary artery disease
8 210787 6 31416574 170899992 Copy number Coronary artery disease
9 211337 6 32582950 170899992 Copy number Coronary artery disease
10 211383 6 32609209 170899992 Copy number Coronary artery disease

Expression for Coronary Heart Disease 1

Search GEO for disease gene expression data for Coronary Heart Disease 1.

Pathways for Coronary Heart Disease 1

Pathways related to Coronary Heart Disease 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.58 CDKN2A MIR126 MIR145 MIR155 MIR17 SOCS1

GO Terms for Coronary Heart Disease 1

Cellular components related to Coronary Heart Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 micro-ribonucleoprotein complex GO:0035068 9.17 H19 MIR126 MIR145 MIR155 MIR17 MIR182

Biological processes related to Coronary Heart Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.7 H19 MIR126 MIR145 MIR155 MIR17 MIR182
2 cholesterol homeostasis GO:0042632 9.54 APOC3 MIR155 MIR208A
3 positive regulation of sprouting angiogenesis GO:1903672 9.48 MIR126 MIR155
4 negative regulation of phosphorylation GO:0042326 9.46 CDKN2A CDKN2B
5 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.43 MIR155 MIR17
6 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.4 APOC3 MIR155
7 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.32 CDKN2A CDKN2B
8 negative regulation of vascular smooth muscle cell dedifferentiation GO:1905175 9.26 MIR145 MIR182
9 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.13 MIR155 MIR17 MIR208A
10 miRNA mediated inhibition of translation GO:0035278 9.02 MIR145 MIR155 MIR17 MIR182 MIR208A

Molecular functions related to Coronary Heart Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR126 MIR145 MIR155 MIR17 MIR182 MIR208A
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN2A CDKN2B

Sources for Coronary Heart Disease 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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