CHDS6
MCID: CRN178
MIFTS: 14

Coronary Heart Disease 6 (CHDS6)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Coronary Heart Disease 6

MalaCards integrated aliases for Coronary Heart Disease 6:

Name: Coronary Heart Disease 6 58 76 30 6
Coronary Heart Disease, Susceptibility to, 6 58 13
Chds6 58 76
Heart, Coronary, Disease, Susceptibility to, Type 6 41

Classifications:



External Ids:

OMIM 58 614466
MeSH 45 D003324
MedGen 43 C3280913

Summaries for Coronary Heart Disease 6

UniProtKB/Swiss-Prot : 76 Coronary heart disease 6: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.

MalaCards based summary : Coronary Heart Disease 6, is also known as coronary heart disease, susceptibility to, 6. An important gene associated with Coronary Heart Disease 6 is MMP3 (Matrix Metallopeptidase 3). Affiliated tissues include heart.

Description from OMIM: 614466

Related Diseases for Coronary Heart Disease 6

Symptoms & Phenotypes for Coronary Heart Disease 6

Clinical features from OMIM:

614466

Drugs & Therapeutics for Coronary Heart Disease 6

Search Clinical Trials , NIH Clinical Center for Coronary Heart Disease 6

Genetic Tests for Coronary Heart Disease 6

Genetic tests related to Coronary Heart Disease 6:

# Genetic test Affiliating Genes
1 Coronary Heart Disease 6 30 MMP3

Anatomical Context for Coronary Heart Disease 6

MalaCards organs/tissues related to Coronary Heart Disease 6:

42
Heart

Publications for Coronary Heart Disease 6

Articles related to Coronary Heart Disease 6:

# Title Authors Year
1
Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men. ( 12485468 )
2002
2
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. ( 12477941 )
2002
3
Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis. ( 10190398 )
1999
4
Stromelysin promoter 5A/6A polymorphism is associated with acute myocardial infarction. ( 10351963 )
1999
5
The 5A/6A polymorphism in the promoter of the stromelysin-1 (MMP-3) gene predicts progression of angiographically determined coronary artery disease in men in the LOCAT gemfibrozil study. Lopid Coronary Angiography Trial. ( 9699891 )
1998
6
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. ( 8662692 )
1996
7
Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis. ( 7727178 )
1995

Variations for Coronary Heart Disease 6

ClinVar genetic disease variations for Coronary Heart Disease 6:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MMP3 MMP3, -1171 5A/6A undetermined variant risk factor

Expression for Coronary Heart Disease 6

Search GEO for disease gene expression data for Coronary Heart Disease 6.

Pathways for Coronary Heart Disease 6

GO Terms for Coronary Heart Disease 6

Sources for Coronary Heart Disease 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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