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MCID: CRN017
MIFTS: 47

Coronary Thrombosis

Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Coronary Thrombosis

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MalaCards integrated aliases for Coronary Thrombosis:

Name: Coronary Thrombosis 12 56 45 15 17 74
Coronary Artery Thrombosis 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:11847
MeSH 45 D003328
SNOMED-CT 69 66514008
ICD10 34 I21 I22
UMLS 74 C0010072
Sources

Summaries for Coronary Thrombosis

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MalaCards based summary : Coronary Thrombosis, also known as coronary artery thrombosis, is related to intracranial embolism and angina pectoris. An important gene associated with Coronary Thrombosis is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and ECM-receptor interaction. The drugs Aspirin and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and neutrophil, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 77 Coronary thrombosis is the formation of a blood clot inside a blood vessel of the heart. This blood clot... more...

Sources

Related Diseases for Coronary Thrombosis

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Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 intracranial embolism 30.3 PLAT SERPINC1
2 angina pectoris 30.2 PLAT SERPINC1
3 heparin-induced thrombocytopenia 30.0 F3 SERPINC1
4 thrombocytopenia 29.7 F3 GP1BA ITGB3
5 thrombocytopenic purpura, autoimmune 29.6 GP1BA GP6 ITGB3
6 protein s deficiency 29.6 F3 SERPINC1
7 thrombophlebitis 29.6 PLAT SERPINC1 SERPINE1
8 catastrophic antiphospholipid syndrome 29.5 F3 SERPINE1
9 acute myocardial infarction 29.5 F3 PLAT SERPINC1 SERPINE1 VWF
10 thrombosis 29.5 F3 GP1BA GP6 P2RY12 PLAT SERPINC1
11 antiphospholipid syndrome 29.4 F3 PLAT SERPINC1 VWF
12 purpura 29.3 F3 ITGB3 SERPINC1 VWF
13 thrombotic thrombocytopenic purpura 29.1 F3 VWF
14 pulmonary embolism 28.9 F3 PLAT SERPINC1 SERPINE1 VWF
15 disseminated intravascular coagulation 28.9 F3 PLAT SERPINC1 SERPINE1
16 essential thrombocythemia 28.8 F3 GP1BA ITGB3 SERPINE1 VWF
17 thrombophilia 28.7 F3 SERPINC1 SERPINE1 VWF
18 arteries, anomalies of 28.6 F3 P2RY12 PLAT SERPINC1 SERPINE1 VWF
19 myocardial infarction 28.6 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
20 heart disease 28.4 F3 PLAT SERPINC1 SERPINE1 VWF
21 vascular disease 27.8 F3 GP1BA ITGB3 PLAT SERPINC1 SERPINE1
22 arterial calcification of infancy 11.2
23 posterior myocardial infarction 10.3 PLAT SERPINC1
24 encephalopathy, familial, with neuroserpin inclusion bodies 10.3 PLAT SERPINC1
25 fetal and neonatal alloimmune thrombocytopenia 10.3 GP1BA ITGB3
26 autosomal dominant macrothrombocytopenia 10.3 GP1BA ITGB3
27 pleuropneumonia 10.3 PLAT SERPINC1
28 dysfibrinogenemia 10.3 PLAT SERPINC1
29 myeloproliferative syndrome, transient 10.3 GP1BA ITGB3
30 clopidogrel resistance 10.2 ITGB3 P2RY12
31 eisenmenger syndrome 10.2 PLAT VWF
32 arteritic anterior ischemic optic neuropathy 10.2 GP1BA ITGB3
33 acquired von willebrand syndrome 10.2 GP1BA VWF
34 plasminogen activator inhibitor-1 deficiency 10.2 PLAT SERPINE1
35 pseudo-von willebrand disease 10.2 GP1BA VWF
36 central serous chorioretinopathy 10.2 PLAT SERPINE1
37 central retinal vein occlusion 10.2 SERPINC1 SERPINF1
38 acute cor pulmonale 10.2 PLAT SERPINE1
39 aspirin allergy 10.2 SERPINC1 SERPINE1
40 acute pulmonary heart disease 10.2 PLAT SERPINE1
41 ischemic colitis 10.1 SERPINC1 SERPINE1
42 subendocardial myocardial infarction 10.1 SERPINC1 SERPINE1
43 livedoid vasculitis 10.1 SERPINC1 SERPINE1
44 ischemic optic neuropathy 10.1 GP1BA ITGB3 SERPINC1
45 meningococcemia 10.1 SERPINC1 SERPINE1
46 post-thrombotic syndrome 10.1 SERPINC1 SERPINE1
47 thrombocytosis 10.1
48 nonarteritic anterior ischemic optic neuropathy 10.1 GP1BA SERPINC1
49 legg-calve-perthes disease 10.1 SERPINC1 SERPINE1
50 retinal artery occlusion 10.1 SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to Coronary Thrombosis
Sources

Symptoms & Phenotypes for Coronary Thrombosis

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MGI Mouse Phenotypes related to Coronary Thrombosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
2 cardiovascular system MP:0005385 9.87 F3 ITGB3 PLAT SERPINC1 SERPINE1 SERPINF1
3 homeostasis/metabolism MP:0005376 9.81 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
4 immune system MP:0005387 9.56 F3 GP6 ITGB3 PLAT SERPINC1 SERPINE1
5 vision/eye MP:0005391 9.1 F3 GP6 ITGB3 PLAT SERPINC1 SERPINF1
Sources

Drugs & Therapeutics for Coronary Thrombosis

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Drugs for Coronary Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
2
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
3
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 70789204 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 46835353 5284616 6436030
6
Atorvastatin Approved Phase 4 134523-00-5 60823
7
Tirofiban Approved Phase 4 144494-65-5 60947
8 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
9 Phosphodiesterase Inhibitors Phase 4
10 Antipyretics Phase 4,Phase 3
11 Phosphodiesterase 3 Inhibitors Phase 4
12 Analgesics Phase 4,Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
14 Analgesics, Non-Narcotic Phase 4,Phase 3
15 Antirheumatic Agents Phase 4,Phase 3
16 Bronchodilator Agents Phase 4
17 Cyclooxygenase Inhibitors Phase 4,Phase 3
18 Anti-Inflammatory Agents Phase 4,Phase 3
19 Respiratory System Agents Phase 4
20 Protective Agents Phase 4
21 Peripheral Nervous System Agents Phase 4,Phase 3
22 Vasodilator Agents Phase 4
23 Anti-Asthmatic Agents Phase 4
24 Autonomic Agents Phase 4
25 Neuroprotective Agents Phase 4
26 Fibrinolytic Agents Phase 4,Phase 3
27 Anti-Infective Agents Phase 4,Phase 1,Phase 2
28 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
29 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
30 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
31 Antifungal Agents Phase 4,Phase 1,Phase 2
32 Immunologic Factors Phase 4,Phase 1,Phase 2
33 Lipid Regulating Agents Phase 4
34 Anticholesteremic Agents Phase 4
35 Antimetabolites Phase 4
36 Hypolipidemic Agents Phase 4
37 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
38 Gastrointestinal Agents Phase 4,Phase 3
39 Anti-Ulcer Agents Phase 4,Phase 3
40 Antacids Phase 4,Phase 3
41 Proton Pump Inhibitors Phase 4,Phase 3
42
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
43
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
44 Purinergic P2 Receptor Antagonists Phase 3,Phase 2
45 Purinergic P2Y Receptor Antagonists Phase 3,Phase 2
46 Neurotransmitter Agents Phase 3,Phase 2
47 Lipoxygenase Inhibitors Phase 3
48 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid Phase 3
49
tannic acid Approved Phase 2 1401-55-4
50
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Scripps Evaluation of Antiplatelet Therapies for Intermediate Duration With the Endeavor Stent (Seaside) Unknown status NCT00963781 Phase 4 Reduced duration (6 months) DAPT
2 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Unknown status NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
3 Safety and Efficacy Study Comparing 3 New Types of Coronary Stents Completed NCT01166685 Phase 4
4 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
5 Comparison of Two Treatment Strategies in Patients With an Acute Coronary Syndrome Without ST Elevation Terminated NCT00445263 Phase 4 TIROFIBAN
6 Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control Withdrawn NCT00713947 Phase 4 during one week for the active treatments;Pantoprazole;Placebo Formula 515
7 Veliflapon (DG-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina Suspended NCT00353067 Phase 3 veliflapon (DG-031)
8 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
9 OCT Evaluation of Healing of COMBO Stent Completed NCT01274234 Phase 1, Phase 2
10 A Double-Blind Study of E5555 in Japanese Patients With Acute Coronary Syndrome Completed NCT00619164 Phase 2 E5555;E5555;E5555;Placebo
11 Maintenance of Platelet Inhibition With Cangrelor Completed NCT00767507 Phase 2 cangrelor
12 Periprocedural Myocardial Infarction: the Role of Human Neutrophil Peptide-1 to 3 Unknown status NCT02591264
13 Monitoring Response to Antiplatelet Therapy Unknown status NCT00327041
14 Angiographic and Intravascular Ultrasound (IVUS) Follow-up After Simultaneously Implanted Different Drug-eluting Stents in Same Individuals Unknown status NCT00973375
15 Independent OCT Registry on Very Late Bioresorbable Scaffold Thrombosis Completed NCT03180931
16 The SCRIPPS DES REAL WORLD Registry Completed NCT00714623
17 Platelet Acetyl Coenzyme A Carboxylase Phosphorylation in Coronary Artery Disease Completed NCT03034148 Not Applicable
18 Xtractâ„¢ Aspiration Catheter Registry Study Completed NCT00349570 Not Applicable
19 The Cholesterol-lowering Efficacy of Probiotic Lactobacillus Plantarum in Hypercholesterolaemic Adults Completed NCT03263104 Not Applicable
20 Assessment of Coagulation and Thrombocyte Function After Termination of Ticagrelor Completed NCT02297971
21 Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement Completed NCT00657436
22 Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease Completed NCT02783963 Not Applicable
23 OFDI-Quantified Intracoronary Thrombus, Antiplatelet Pretreatment Effect and Myocardial Reperfusion Completed NCT03342521
24 The Cork and Kerry Diabetes and Heart Disease Study (Phase II) Mitchelstown Cohort Completed NCT03191227
25 Proteomic Profiling of Coronary Thrombus in Acute Myocardial Infarction Recruiting NCT03731884
26 Myocardial Injury Following Non-cardiac Surgery Recruiting NCT03317561
27 Assessment of Thrombotic Status in Patients With Acute Coronary Syndrome Recruiting NCT02562690
28 EKG Criteria and Identification of Acute Coronary Occlusion Recruiting NCT03863327
29 PRE-DETERMINE Cohort Study Active, not recruiting NCT01114269
30 The Efficacy of Cholesterol-lowering Probiotic Lactobacillus Plantarum LPLDL® in Hypercholesterolemic Adults. Not yet recruiting NCT03540108 Not Applicable

Search NIH Clinical Center for Coronary Thrombosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: coronary thrombosis

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Genetic Tests for Coronary Thrombosis

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Anatomical Context for Coronary Thrombosis

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MalaCards organs/tissues related to Coronary Thrombosis:

42
Heart, Kidney, Neutrophil, Testes, Myeloid, Endothelial, Brain
Sources

Publications for Coronary Thrombosis

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Articles related to Coronary Thrombosis:

(show top 50) (show all 868)
# Title Authors Year
1
Low-dose i.v. urokinase for coronary thrombosis in Kawasaki disease. ( 30854729 )
2019
2
Sudden unexpected death due to coronary thrombosis associated with isolated necrotizing vasculitis in the coronary arteries of a young adult. ( 30810977 )
2019
3
Expression and Activity of Platelet Endothelial Nitric Oxide Synthase Are Decreased in Patients with Coronary Thrombosis and Stenosis. ( 30800248 )
2019
4
Update on pathological platelet activation in coronary thrombosis. ( 30317596 )
2019
5
Therapeutic application of contrast ultrasound in ST elevation myocardial infarction: Role in coronary thrombosis and microvascular obstruction. ( 28868906 )
2019
6
Coronary thrombosis in acute pancreatitis. ( 30269287 )
2019
7
Intracoronary recombinant tissue plasminogen activator in an infant with hypoplastic left heart syndrome and complete left main coronary artery thrombosis. ( 30702202 )
2019
8
Electric Shock-Induced Coronary Artery Thrombosis and Dissection. ( 30028978 )
2019
9
Coronary Artery Thrombosis in a Neonate With Critical Aortic Stenosis. ( 31034441 )
2019
10
Arterial events in cancer patients-the case of acute coronary thrombosis. ( 30701104 )
2018
11
Optical Coherence Tomography for Guiding Plaque Stabilization in a Patient With Myocardial Infarction and Massive Coronary Thrombosis. ( 29958180 )
2018
12
Serious Coronary Thrombosis and Pulmonary Artery Thrombosis Revealing Behçet's Disease. ( 29900996 )
2018
13
rLj-RGD3, a novel recombinant toxin protein from Lampetra japonica, prevents coronary thrombosis-induced acute myocardial infarction by inhibiting platelet functions in rats. ( 29407168 )
2018
14
Multiple distal coronary artery thrombosis in acute myocardial infarction: a rare presentation. ( 30042110 )
2018
15
Native coronary artery thrombosis in the setting of heparin-induced thrombocytopenia: a case report. ( 31020214 )
2018
16
Triple Coronary Artery Thrombosis Presenting as Acute Anterior ST-Segment Elevation Myocardial Infarction. ( 30410294 )
2018
17
Publisher Correction: GLS-409, an Antagonist of Both P2Y1 and P2Y12, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation. ( 30498241 )
2018
18
Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. ( 29244159 )
2018
19
The influence of the manual thrombus aspiration on the short term effectiveness of the percutaneous revascularization in patients with coronary artery thrombosis. ( 29602921 )
2018
20
Multiple Culprit Coronary Artery Thrombosis in a Patient with Coronary Ectasia. ( 29854473 )
2018
21
GLS-409, an Antagonist of Both P2Y1 and P2Y12, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation. ( 30266987 )
2018
22
Understanding the Impact of Stent and Scaffold Material and Strut Design on Coronary Artery Thrombosis from the Basic and Clinical Points of View. ( 30181463 )
2018
23
Left Main Coronary Artery Thrombosis With Acute Myocardial Infarction: A Management Dilemma. ( 28641723 )
2017
24
Coronary thrombosis in three coronary arteries due to whey protein. ( 27839839 )
2017
25
Tissue plasminogen activator for neonatal coronary thrombosis presenting with mitral valve regurgitation and impaired ventricular function. ( 28140523 )
2017
26
Sex differences in the effect of diabetes mellitus on platelet reactivity and coronary thrombosis: From the Assessment of Dual Antiplatelet Therapy with Drug-Eluting Stents (ADAPT-DES) study. ( 28867009 )
2017
27
Adam Hammer, MD: The St. Louis Physician Who Made the First Ever Diagnosis of Coronary Thrombosis and Acute Myocardial Infarction in a Living Patient. ( 30228542 )
2017
28
Takotsubo syndrome after pericardial tamponade following cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation and complicated by right coronary artery thrombosis. ( 28421588 )
2017
29
Silent Progression of Coronary Artery Thrombosis in a Pregnant Woman With Anomalous Origin of Left Coronary Artery From the Pulmonary Artery. ( 28250356 )
2017
30
Epoetin Alfa: A Cause of Coronary Artery Thrombosis. ( 29098093 )
2017
31
Unexpected Coronary Thrombosis Induced By Antiphospholipid Syndrome (Hughes Syndrome): Case Report. ( 30141609 )
2016
32
How should I treat a massive left main coronary artery thrombosis in a 49-year-old woman in the context of cardiogenic shock? ( 27056129 )
2016
33
Coronary Thrombosis without Dissection following Blunt Trauma. ( 27006836 )
2016
34
Coronary Thrombosis and Major Bleeding After PCI With Drug-Eluting Stents: Risk Scores From PARIS. ( 27079334 )
2016
35
Multifocal coronary thrombosis on nondisrupted plaque: observation with optical coherence tomography. ( 27159264 )
2016
36
Multiple coronary thrombosis. ( 27489604 )
2016
37
CASE 11-2016 Perioperative Coronary Thrombosis in a Patient With Multiple Second-Generation Drug-Eluting Stents: Is It Time for a Paradigm Shift? ( 27543999 )
2016
38
Coronary thrombosis in diabetes: Are we doing enough? ( 27555606 )
2016
39
Translation from the data of clinical trials to precision medicine: limitation of the current risk score for predicting coronary thrombosis and major bleeding. ( 27746980 )
2016
40
Early Coronary Thrombosis without ST-Segment Elevation Following Repair of Acute Aortic Dissection. ( 28097197 )
2016
41
Early Post-Operative Coronary Thrombosis Following Repair of a Proximal Coronary Artery Fistula. ( 28208917 )
2016
42
Endothelial erosion of plaques as a substrate for coronary thrombosis. ( 26791872 )
2016
43
Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature. ( 26607055 )
2016
44
Left main coronary artery thrombosis with distal coronary embolization in a patient with methyltetrahydrofolate reductase C677T mutation presenting with STEMI. ( 27668343 )
2016
45
Left main coronary artery thrombosis with distal coronary embolization in a patient with methyltetrahydrofolate reductase C677T mutation presenting with STEMI. ( 27760988 )
2016
46
Acute and spontaneous coronary thrombosis in non-culprit artery during percutaneous coronary intervention in myocardial infarction with ST-segment elevation: A "shocking" case. ( 28785706 )
2015
47
Resolution of Extensive Coronary Thrombosis under Rivaroxaban Treatment. ( 26761372 )
2015
48
Evading the fate of Pheidippides: acute coronary thrombosis in a young marathon runner with minimal atherosclerosis but sickle cell trait. ( 26331117 )
2015
49
Acute Myocardial Infarction in a Neonate Caused by a Coronary Thrombosis: a Considerable Diagnostic and Therapeutic Challenge. ( 26297178 )
2015
50
Coronary Thrombosis and Type A Aortic Dissection. ( 25980980 )
2015
Sources

Variations for Coronary Thrombosis

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Expression for Coronary Thrombosis

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Search GEO for disease gene expression data for Coronary Thrombosis.
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Pathways for Coronary Thrombosis

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Pathways related to Coronary Thrombosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 12.69 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
2
ECM-receptor interaction 38
Show member pathways
 11.89 GP1BA GP6 ITGB3 VWF
3
Complement and coagulation cascades 1 38
11.8 F3 PLAT SERPINC1 SERPINE1 VWF
4
Adhesion 4
11.78 F3 ITGB3 SERPINE1
5
Platelet activation 38
11.65 GP1BA GP6 ITGB3 P2RY12 VWF
6
Integrin alphaIIb beta3 signaling 67
Show member pathways
 11.62 GP1BA ITGB3 VWF
7
Angiogenesis (CST) 4
11.56 F3 ITGB3 VWF
8
Formation of Fibrin Clot (Clotting Cascade) 67
Show member pathways
 11.37 F3 GP1BA GP6 PLAT SERPINC1 SERPINE1
9
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 62
11.33 GP6 ITGB3 P2RY12 VWF
10
amb2 Integrin signaling 1
11.21 GP1BA PLAT
11
Platelet Adhesion to exposed collagen 67
10.66 GP1BA GP6 VWF
12
Dissolution of Fibrin Clot 67
10.61 PLAT SERPINE1
13
GP1b-IX-V activation signalling 67
10.48 GP1BA VWF
Sources

GO Terms for Coronary Thrombosis

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Cellular components related to Coronary Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 F3 PLAT SERPINC1 SERPINE1 SERPINF1 VWF
2 extracellular exosome GO:0070062 9.76 GP1BA GP6 ITGB3 PLAT SERPINC1 SERPINE1
3 extracellular space GO:0005615 9.73 F3 GP1BA PLAT SERPINC1 SERPINE1 SERPINF1
4 cell surface GO:0009986 9.43 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
5 collagen-containing extracellular matrix GO:0062023 9.1 F3 PLAT SERPINC1 SERPINE1 SERPINF1 VWF

Biological processes related to Coronary Thrombosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.69 ITGB3 SERPINE1 VWF
2 negative regulation of endopeptidase activity GO:0010951 9.65 SERPINC1 SERPINE1 SERPINF1
3 platelet degranulation GO:0002576 9.61 ITGB3 SERPINE1 VWF
4 platelet activation GO:0030168 9.55 GP1BA GP6 ITGB3 P2RY12 VWF
5 platelet aggregation GO:0070527 9.5 GP1BA ITGB3 P2RY12
6 cell-substrate adhesion GO:0031589 9.49 ITGB3 VWF
7 blood coagulation, intrinsic pathway GO:0007597 9.46 GP1BA VWF
8 fibrinolysis GO:0042730 9.43 GP1BA PLAT SERPINE1
9 hemostasis GO:0007599 9.43 F3 GP1BA GP6 P2RY12 SERPINC1 VWF
10 regulation of blood coagulation GO:0030193 9.4 GP1BA SERPINC1
11 smooth muscle cell migration GO:0014909 9.37 ITGB3 PLAT
12 blood coagulation GO:0007596 9.23 F3 GP1BA GP6 ITGB3 P2RY12 PLAT

Molecular functions related to Coronary Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase inhibitor activity GO:0004867 9.13 SERPINC1 SERPINE1 SERPINF1
2 protease binding GO:0002020 9.02 F3 ITGB3 SERPINC1 SERPINE1 VWF
Sources

Sources for Coronary Thrombosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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