MCID: CRN319
MIFTS: 38

Coronavirus Infection

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Coronavirus Infection

MalaCards integrated aliases for Coronavirus Infection:

Name: Coronavirus Infection 12
Coronavirus Infections 54 42

Classifications:



External Ids:

Disease Ontology 12 DOID:0080599

Summaries for Coronavirus Infection

MedlinePlus : 42 What are coronavirus infections? Coronaviruses are a group of common viruses. They are named for the crown-like spikes on the surface of the virus. Some coronaviruses only affect animals, but others can also affect humans. Most people get infected with human coronaviruses at some time in their life. This usually causes mild to moderate upper-respiratory infections, like the common cold. But they can also cause more severe illnesses such as bronchitis and pneumonia. There are several different types of human coronaviruses, including the the 2019 Novel Coronavirus (2019-nCoV) and the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) coronaviruses. How are coronavirus infections spread? Human coronaviruses usually spread from an infected person to others through The air by coughing and sneezing Close personal contact, such as touching or shaking hands Touching an object or surface with the virus on it, then touching your mouth, nose, or eyes before washing your hands Rarely, feces (poop) Who is at risk for coronavirus infections? Anyone can get a coronavirus infection, but young children are most likely to get infected. In the United States, infections are more common in the fall and winter. What are the symptoms of coronavirus infections? The symptoms depend on the type of coronavirus and how serious the infection is. If you have a mild to moderate upper-respiratory infection such as the common cold, your symptoms may include Runny nose Headache Cough Sore throat Fever Not feeling well overall Some coronaviruses can cause severe symptoms. The infections may turn into bronchitis and pneumonia, which cause symptoms such as Fever, which may be quite high if you have pneumonia Cough with mucus Shortness of breath Chest pain or tightness when you breathe and cough Severe infections are more common in people with heart or lung diseases, people with weakened immune systems, infants, and older adults. How are coronavirus infections diagnosed? To make a diagnosis, your health care provider will Take your medical history, including asking about your symptoms Do a physical exam May do blood tests May do lab tests of sputum, a sample from a throat swab, or other respiratory specimens What are the treatments for coronavirus infections? There are no specific treatments for coronavirus infections. Most people will get better on their own. However, you can relieve your symptoms by Taking over-the-counter medicines for pain, fever, and cough. However, do not give aspirin to children. And do not give cough medicine to children under four. Using a room humidifier or taking a hot shower to help ease a sore throat and cough Getting plenty of rest Drinking fluids If you are worried about your symptoms, contact your health care provider. Can coronavirus infections be prevented? Right now, there aren't any vaccines to prevent human coronavirus infections. But you may able to reduce your risk of getting or spreading an infection by Washing hands often with soap and water for at least 20 seconds Avoiding touching your face, nose, or mouth with unwashed hands Avoiding close contact with people who are sick Cleaning and disinfecting surfaces that you frequently touch Covering coughs and sneezes with a tissue. Then throw away the tissue and wash your hands. Staying home when sick Centers for Disease Control and Prevention

MalaCards based summary : Coronavirus Infection, also known as coronavirus infections, is related to severe acute respiratory syndrome and myocarditis. An important gene associated with Coronavirus Infection is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Heparin and Streptokinase have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and heart, and related phenotype is immune system.

Disease Ontology : 12 A viral infectious disease that has material basis in Coronavirus.

Related Diseases for Coronavirus Infection

Diseases related to Coronavirus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 severe acute respiratory syndrome 31.7 TMPRSS2 MX1 MBL2 CLEC4M CCL2 ACE2
2 myocarditis 29.9 HLA-B CCL2 CASP3
3 immune deficiency disease 29.9 MBL2 HLA-B CLEC4M CCL2
4 human immunodeficiency virus type 1 29.4 HLA-C HLA-B DPP4 CLEC4M CCL2
5 influenza 28.7 TMPRSS2 SOCS3 MX1 CCL2
6 hepatitis c 28.7 SOCS3 MX1 IFNAR1 CLEC4M
7 acute respiratory coronavirus infection 12.4
8 2019 novel coronavirus 12.1
9 peritonitis 10.6
10 gastroenteritis 10.5
11 diarrhea 10.5
12 respiratory failure 10.4
13 demyelinating disease 10.3
14 cytokine deficiency 10.3
15 lymphopenia 10.3
16 indolent b-cell non-hodgkin lymphoma 10.3 MCL1 BAK1
17 bronchitis 10.3
18 mannose-binding lectin deficiency 10.3 MBL2 MASP2
19 nephrosclerosis 10.3 CCL2 CASP3 ACE2
20 enterocolitis 10.2
21 lung disease 10.2
22 intracranial aneurysm 10.2 CCL2 CASP3 ACE2
23 idiopathic bronchiectasis 10.2 HLA-C HLA-B
24 cytomegalovirus infection 10.2 HLA-B CCL2 CASP3
25 colorectal cancer, hereditary nonpolyposis, type 8 10.2 HLA-C HLA-B
26 common cold 10.2
27 bronchopneumonia 10.2
28 idiopathic interstitial pneumonia 10.2
29 pulmonary fibrosis 10.2
30 encephalitis 10.2
31 barre-lieou syndrome 10.2 MCL1 DPP4
32 bronchiolitis 10.2
33 spondyloarthropathy 10.1 HLA-C HLA-B CCL2
34 chlamydia 10.1 MCL1 MBL2 CCL2
35 pityriasis rosea 10.1 HLA-C HLA-B
36 autoimmune disease 10.1
37 viral pneumonia 10.1
38 neutropenia 10.1
39 dysentery 10.1
40 vaccinia 10.1
41 pneumonia 10.1
42 congestive heart failure 10.1
43 mental retardation, autosomal dominant 40 10.1 HLA-B DPP4
44 angioedema 10.0 MBL2 MASP2 DPP4
45 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
46 carbonic anhydrase va deficiency, hyperammonemia due to 10.0
47 dilated cardiomyopathy 10.0
48 purpura 10.0
49 kidney disease 10.0
50 severe combined immunodeficiency 10.0

Graphical network of the top 20 diseases related to Coronavirus Infection:



Diseases related to Coronavirus Infection

Symptoms & Phenotypes for Coronavirus Infection

MGI Mouse Phenotypes related to Coronavirus Infection:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 ACE2 BAK1 CASP3 CCL2 CLEC4M IFNAR1

Drugs & Therapeutics for Coronavirus Infection

Drugs for Coronavirus Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
2
Streptokinase Approved, Investigational Phase 3 9002-01-1
3
Lopinavir Approved Phase 2, Phase 3 192725-17-0 92727
4
Ritonavir Approved, Investigational Phase 2, Phase 3 155213-67-5 392622
5
tannic acid Approved Phase 2, Phase 3 1401-55-4
6
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
7
Interferon beta-1b Approved Phase 2, Phase 3 145155-23-3
8
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
9 Fibrinolytic Agents Phase 3
10 Anticoagulants Phase 3
11 Calcium, Dietary Phase 3
12 calcium heparin Phase 3
13 HIV Protease Inhibitors Phase 2, Phase 3
14 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
15
protease inhibitors Phase 2, Phase 3
16 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
17 Anti-Infective Agents Phase 2, Phase 3
18 Anti-Retroviral Agents Phase 2, Phase 3
19 Antiviral Agents Phase 2, Phase 3
20 Anti-HIV Agents Phase 2, Phase 3
21 interferons Phase 2, Phase 3
22 Interferon-beta Phase 2, Phase 3
23 Interferon-alpha Phase 2
24 Pharmaceutical Solutions Phase 1, Phase 2
25
Sorbitol Approved Phase 1 50-70-4 5780
26
Glutamic acid Approved, Nutraceutical Phase 1 56-86-0 33032
27 Immunoglobulins Phase 1
28 Antibodies Phase 1
29 Antibodies, Monoclonal Phase 1
30 Somatomedin B Phase 1
31 Rho(D) Immune Globulin Phase 1
32 Immunoglobulins, Intravenous Phase 1
33 gamma-Globulins Phase 1
34 Myeloma Proteins Phase 1
35 Paraproteins Phase 1
36
Ribavirin Approved 36791-04-5 37542
37 Antimetabolites

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Streptokinase Versus Unfractionated Heparin Nebulization in Patients With Severe Acute Respiratory Distress Syndrome (ARDS): A Partially Randomized Controlled Trial Completed NCT03465085 Phase 3 Unfractionated heparin;Streptokinase
2 MERS-CoV Infection tReated With A Combination of Lopinavir /Ritonavir and Interferon Beta-1b: a Multicenter, Placebo-controlled, Double-blind Randomized Trial Recruiting NCT02845843 Phase 2, Phase 3 Combination of Lopinavir /Ritonavir and Interferon beta-1b;Placebo
3 A Randomized, Dose-ranging Study of Alferon® LDO {Low Dose Oral Interferon Alfa-n3 (Human Leukocyte Derived)} in Normal Volunteers and/or Asymptomatic Subjects With Exposure to a Person Known to Have SARS or Possible SARS Completed NCT00215826 Phase 2 Alferon LDO
4 Double-blind, Placebo-controlled Study With an Open Dose Selection Period for Assessing the Safety and Immunogenicity of the Drug "BVRS-GamVac", a Vector Vaccine for the Prevention of the Middle East Respiratory Syndrome, Lyophilisate for the Preparation of a Solution for Intramuscular Administration, With the Participation of Healthy Volunteers Recruiting NCT04130594 Phase 1, Phase 2
5 Double-blind, Placebo-controlled Study With an Open Dose Selection Period for Assessing the Safety and Immunogenicity of the Drug "BVRS-GamVac-Combi", a Combined Vector Vaccine for the Prevention of the Middle East Respiratory Syndrome, Lyophilisate for the Preparation of a Solution for Intramuscular Administration, With the Participation of Healthy Volunteers Recruiting NCT04128059 Phase 1, Phase 2 BVRS-GamVac-Combi
6 An Open, Single Center Phase I Trial to Assess the Safety, Tolerability and Immunogenicity of Two Ascending Doses of the Candidate Vaccine MVA-MERS-S Completed NCT03615911 Phase 1
7 A Phase I Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Co-administered MERS-CoV Antibodies REGN3048 and REGN3051 vs. Placebo in Healthy Adults Completed NCT03301090 Phase 1
8 A Phase 1, Randomized Double-Blind, Placebo-Controlled, Single Ascending Dose Safety, Tolerability, and Pharmacokinetics Study of SAB-301 in Healthy Adults Completed NCT02788188 Phase 1
9 A Phase Ib Study to Determine the Safety and Immunogenicity of the Candidate Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Vaccine ChAdOx1 MERS in Healthy Adult Middle Eastern Volunteers Recruiting NCT04170829 Phase 1
10 A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Vaccine ChAdOx1 MERS in UK Healthy Adult Volunteers Recruiting NCT03399578 Phase 1
11 A Two-center, Randomized, Double-blind, Placebo-controlled, Phase Ib Study to Assess the Safety, Tolerability and Immunogenicity of Two Ascending Doses of the Candidate Vaccine MVA-MERS-S_DF-1 in Healthy Study Subjects Not yet recruiting NCT04119440 Phase 1
12 Phase I, Double-Blinded, Placebo-Controlled Dosage Escalation Study of the Safety and Immunogenicity of Adjuvanted and Non-Adjuvanted Inactivated SARS Coronavirus (SARS-CoV) Vaccine Administered by the Intramuscular Route Withdrawn NCT00533741 Phase 1 Aluminum hydroxide;Placebo
13 A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome Unknown status NCT00578825 Lopinavir / Ritonavir plus Ribavirin
14 Seroprevalence of IgG Antibodies to Middle East Respiratory Syndrome Coronavirus in Asymptomatic Healthcare Workers After Treatment of Confirmed MERS Patient Completed NCT02497885
15 An Investigation of the Inflammatory Response in Severe Acute Respiratory Syndrome (SARS) Completed NCT00066209
16 Collection of Convalescent SARS Plasma by Apheresis Completed NCT00342524
17 Testing of Respiratory Specimens for the Validation of the QIAGEN ResPlex II Advanced Panel Test and the Artus Influenza A/B RT-PCR Test Completed NCT01302418
18 Contamination During Removal of Two Different Personal Protective Systems When Working Under Conditions Requiring Enhanced Respiratory and Contact Precautions Completed NCT00150475
19 The 15-year Impact of Severe Acute Respiratory Syndrome on Organ Functions, Exercise Capacity, and Quality of Life in Survivors. Recruiting NCT03443102
20 Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure Recruiting NCT03225807
21 An International Observational Study to Characterize Adults Who Are Hospitalized With Influenza or Other Targeted Respiratory Viruses Recruiting NCT01056185
22 The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes Withdrawn NCT00172263
23 Immune Responses, Transmission and Nucleotide Polymorphisms in Families With SARS Virus Infections Withdrawn NCT00523276
24 Clinical Evaluation and Management of Persons With Severe Acute Respiratory Syndrome (SARS) Withdrawn NCT00073086

Search NIH Clinical Center for Coronavirus Infection

Genetic Tests for Coronavirus Infection

Anatomical Context for Coronavirus Infection

MalaCards organs/tissues related to Coronavirus Infection:

40
Testes, Lung, Heart, Eye, Kidney, T Cells, B Cells

Publications for Coronavirus Infection

Articles related to Coronavirus Infection:

(show top 50) (show all 861)
# Title Authors PMID Year
1
Precision mouse models with expanded tropism for human pathogens. 42
31451733 2019
2
Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design. 42
31452044 2019
3
Middle East respiratory syndrome: making the case for surveillance of transboundary coronaviruses in the Middle East. 42
31564740 2019
4
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2. 54 61
19297479 2009
5
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection. 54 61
17974127 2007
6
Angiotensin-converting enzyme 2 in lung diseases. 54 61
16581295 2006
7
Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. 54 61
15838797 2005
8
[Expert consensus for bronchoscopy during the epidemic of 2019 Novel Coronavirus infection (Trial version)]. 61
32033514 2020
9
Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement. 61
32034659 2020
10
[First case of 2019 novel coronavirus infection in children in Shanghai]. 61
32023679 2020
11
[Suggestions for prevention of 2019 novel coronavirus infection in otolaryngology head and neck surgery medical staff]. 61
32023680 2020
12
[Prevention and control program on 2019 novel coronavirus infection in Children's digestive endoscopy center]. 61
32023683 2020
13
miRNA repertoire and host immune factor regulation upon avian coronavirus infection in eggs. 61
32025807 2020
14
Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue. 61
32026147 2020
15
[Suggestions for disinfection of ophthalmic examination equipment and protection of ophthalmologist against 2019 novel coronavirus infection]. 61
32035428 2020
16
Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition). 61
32028773 2020
17
[Recommendations on extracorporeal life support for critically ill patients with novel coronavirus pneumonia]. 61
32035430 2020
18
Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy. 61
32013309 2020
19
[Diagnosis and clinical management of 2019 novel coronavirus infection: an operational recommendation of Peking Union Medical College Hospital (V2.0)]. 61
32023681 2020
20
Novel coronavirus infection during the 2019-2020 epidemic: preparing intensive care units-the experience in Sichuan Province, China. 61
32025779 2020
21
[Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition)]. 61
32035429 2020
22
Evolving status of the 2019 novel coronavirus Infection: proposal of conventional serologic assays for disease diagnosis and infection monitoring [Commentary/Review]. 61
32031264 2020
23
Coronavirus infections reported by ProMED, February 2000-January 2020. 61
32036011 2020
24
Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China. 61
32031568 2020
25
[Facing the pandemic of 2019 novel coronavirus infections: the pediatric perspectives]. 61
32023678 2020
26
Coronavirus Infections-More Than Just the Common Cold. 61
31971553 2020
27
Coronavirus infections and immune responses. 61
31981224 2020
28
Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020. 61
31992388 2020
29
Three Amino Acid Changes in Avian Coronavirus Spike Protein Allow Binding to Kidney Tissue. 61
31694947 2020
30
Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression. 61
31694960 2020
31
Immunohistochemical and molecular detection of natural cases of bovine rotavirus and coronavirus infection causing enteritis in dairy calves. 61
31639467 2020
32
Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs. 61
31692019 2020
33
Diabetes Mellitus, Hypertension, and Death among 32 Patients with MERS-CoV Infection, Saudi Arabia. 61
31855530 2020
34
Evaluation of Activation and Inflammatory Activity of Myeloid Cells During Pathogenic Human Coronavirus Infection. 61
31883097 2020
35
Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia. 61
31843650 2019
36
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. 61
31852899 2019
37
The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device. 61
31942559 2019
38
Surface-displayed porcine IFN-λ3 in Lactobacillus plantarum inhibits porcine enteric coronavirus infection of porcine intestinal epithelial cells. 61
31838830 2019
39
Middle East respiratory syndrome-coronavirus infection into established hDDP4-transgenic mice accelerates lung damage via activation of the pro-inflammatory response and pulmonary fibrosis. 61
31838832 2019
40
Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus. 61
31539770 2019
41
Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity. 61
31462558 2019
42
Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway. 61
31385116 2019
43
Typical epidemiology of respiratory virus infections in a Brazilian slum. 61
31769524 2019
44
A review of asymptomatic and sub-clinical Middle East Respiratory Syndrome Coronavirus Infections. 61
31781765 2019
45
Isolation and characterization of avian coronavirus from healthy Eclectus parrots (Eclectus roratus) from Indonesia. 61
32009759 2019
46
Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections. 61
31423970 2019
47
Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica). 61
31652964 2019
48
Detection of selected viral pathogens in dogs with canine infectious respiratory disease in Austria. 61
31301071 2019
49
Mucosal Immune Response to Feline Enteric Coronavirus Infection. 61
31569783 2019
50
Risk Factors for Fatal Middle East Respiratory Syndrome Coronavirus Infections in Saudi Arabia: Analysis of the WHO Line List, 2013-2018. 61
31318592 2019

Variations for Coronavirus Infection

Expression for Coronavirus Infection

Search GEO for disease gene expression data for Coronavirus Infection.

Pathways for Coronavirus Infection

Pathways related to Coronavirus Infection according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 SOCS3 PRSS2 MX1 MCL1 MBL2 MASP2
2
Show member pathways
12.92 SOCS3 MX1 MCL1 IFNL1 IFNAR1 HLA-C
3
Show member pathways
12.88 SOCS3 MX1 MBL2 IFNAR1 CCL2 CASP3
4
Show member pathways
12.77 IFNAR1 HLA-C HLA-B CCL2 CASP3 BAK1
5
Show member pathways
12.7 MX1 MCL1 IFNAR1 HLA-C HLA-B CASP3
6
Show member pathways
12.33 IFNAR1 HLA-C HLA-B CASP3
7
Show member pathways
12.32 SOCS3 MX1 IFNAR1 HLA-C HLA-B
8
Show member pathways
12.19 SOCS3 MCL1 IFNL1 IFNAR1
9 12.19 SOCS3 IFNAR1 HLA-C HLA-B CCL2 CASP3
10 12.15 HLA-C HLA-B CASP3 BAK1
11 12.1 MCL1 CASP6 CASP3 BAK1
12
Show member pathways
12.07 TMPRSS2 SOCS3 PRSS2 MX1 IFNAR1 HLA-C
13
Show member pathways
12.06 SOCS3 MX1 IFNAR1 HLA-C HLA-B
14 11.96 MBL2 HLA-C HLA-B CLEC4M
15 11.81 SOCS3 MCL1 CCL2
16 11.79 SOCS3 CCL2 CASP3
17
Show member pathways
11.48 MCL1 CASP6 CASP3 BAK1
18
Show member pathways
10.91 SOCS3 MX1 IFNAR1
19 10.86 SOCS3 CCL2

GO Terms for Coronavirus Infection

Cellular components related to Coronavirus Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 TMPRSS2 PRSS2 MBL2 MASP2 IFNL1 DPP4
2 MHC class I protein complex GO:0042612 8.96 HLA-C HLA-B
3 Bcl-2 family protein complex GO:0097136 8.62 MCL1 BAK1

Biological processes related to Coronavirus Infection according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.91 MX1 MBL2 MASP2 IFNL1 CLEC4M
2 immune system process GO:0002376 9.91 MX1 MBL2 MASP2 HLA-C HLA-B CLEC4M
3 proteolysis GO:0006508 9.8 TMPRSS2 PRSS2 MASP2 DPP4 CASP6 CASP3
4 viral entry into host cell GO:0046718 9.67 DPP4 CLEC4M ACE2
5 execution phase of apoptosis GO:0097194 9.55 CASP6 CASP3
6 cellular homeostasis GO:0019725 9.54 MCL1 CCL2
7 antigen processing and presentation GO:0019882 9.54 HLA-C HLA-B CLEC4M
8 viral genome replication GO:0019079 9.52 CLEC4M CCL2
9 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.5 MCL1 CASP3 BAK1
10 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.48 HLA-C HLA-B
11 complement activation, lectin pathway GO:0001867 9.46 MBL2 MASP2
12 type I interferon signaling pathway GO:0060337 9.46 MX1 IFNAR1 HLA-C HLA-B
13 cytokine-mediated signaling pathway GO:0019221 9.43 SOCS3 MCL1 IFNL1 IFNAR1 CCL2 CASP3
14 cellular response to staurosporine GO:0072734 9.4 CASP6 CASP3
15 JAK-STAT cascade GO:0007259 8.92 SOCS3 IFNL1 IFNAR1 CCL2

Molecular functions related to Coronavirus Infection according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.32 TMPRSS2 SPIDR SOCS3 PRSS2 POLD1 MX1
2 hydrolase activity GO:0016787 10.06 TMPRSS2 PRSS2 POLD1 MASP2 DPP4 CASP6
3 signaling receptor binding GO:0005102 9.8 MBL2 IFNL1 HLA-B DPP4 CCL2
4 virus receptor activity GO:0001618 9.65 DPP4 CLEC4M ACE2
5 serine-type endopeptidase activity GO:0004252 9.62 TMPRSS2 PRSS2 MASP2 DPP4
6 calcium-dependent protein binding GO:0048306 9.61 MBL2 MASP2 CLEC4M
7 serine-type peptidase activity GO:0008236 9.56 TMPRSS2 PRSS2 MASP2 DPP4
8 dipeptidyl-peptidase activity GO:0008239 9.51 DPP4 ACE2
9 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.49 CASP6 CASP3
10 peptidase activity GO:0008233 9.17 TMPRSS2 PRSS2 MASP2 DPP4 CASP6 CASP3
11 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.16 CASP6 CASP3
12 peptide antigen binding GO:0042605 9.13 HLA-C HLA-B CLEC4M

Sources for Coronavirus Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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