MCID: CRN011
MIFTS: 24

Coronin-1a Deficiency

Categories: Immune diseases

Aliases & Classifications for Coronin-1a Deficiency

MalaCards integrated aliases for Coronin-1a Deficiency:

Name: Coronin-1a Deficiency 12 15
Coronin 1a 13

Classifications:



External Ids:

Disease Ontology 12 DOID:0060019

Summaries for Coronin-1a Deficiency

Disease Ontology : 12 A severe combined immunodeficiency that is an actin regulator when mutated results in SCID through inhibition of thymic egress of mature thymocytes into peripheral lymphoid organs.

MalaCards based summary : Coronin-1a Deficiency, also known as coronin 1a, is related to immunodeficiency 8 and graft-versus-host disease. An important gene associated with Coronin-1a Deficiency is CORO1A (Coronin 1A). Affiliated tissues include t cells, bone and b cells, and related phenotypes are endocrine/exocrine gland and immune system

Related Diseases for Coronin-1a Deficiency

Diseases related to Coronin-1a Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 immunodeficiency 8 11.7
2 graft-versus-host disease 10.1
3 severe combined immunodeficiency 10.1
4 bone resorption disease 10.1
5 combined t cell and b cell immunodeficiency 10.1
6 acute graft versus host disease 10.1
7 myeloma, multiple 9.7 CXCR4 LIG4

Graphical network of the top 20 diseases related to Coronin-1a Deficiency:



Diseases related to Coronin-1a Deficiency

Symptoms & Phenotypes for Coronin-1a Deficiency

MGI Mouse Phenotypes related to Coronin-1a Deficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.26 CORO1A CORO1C CXCR4 LIG4
2 immune system MP:0005387 9.02 CORO1A CORO1B CORO1C CXCR4 LIG4

Drugs & Therapeutics for Coronin-1a Deficiency

Search Clinical Trials , NIH Clinical Center for Coronin-1a Deficiency

Genetic Tests for Coronin-1a Deficiency

Anatomical Context for Coronin-1a Deficiency

MalaCards organs/tissues related to Coronin-1a Deficiency:

42
T Cells, Bone, B Cells, Endothelial, Neutrophil

Publications for Coronin-1a Deficiency

Articles related to Coronin-1a Deficiency:

(show all 35)
# Title Authors Year
1
Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway. ( 30903850 )
2019
2
The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis. ( 30453345 )
2018
3
PtpA, a secreted tyrosine phosphatase from Staphylococcus aureus, contributes to virulence and interacts with coronin-1A during infection. ( 30131335 )
2018
4
Emergent Role of Coronin-1a in Neuronal Signaling. ( 28215292 )
2017
5
Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K. ( 28300073 )
2017
6
Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. ( 28615221 )
2017
7
Neuronal filopodium formation induced by the membrane glycoprotein M6a (Gpm6a) is facilitated by coronin-1a, Rac1, and p21-activated kinase 1 (Pak1). ( 26809475 )
2016
8
Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A. ( 27566541 )
2016
9
Coronin-1a is a potential therapeutic target for activated T cell-related immune disorders. ( 24862375 )
2015
10
Coronin-1A: immune deficiency in humans and mice. ( 25666293 )
2015
11
Novel protein kinase C θ: coronin 1A complex in T lymphocytes. ( 25889880 )
2015
12
Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation. ( 25936522 )
2015
13
The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects. ( 26108624 )
2015
14
Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease. ( 24752751 )
2014
15
ZCH-2B8a, an antibody targeting actin-binding protein coronin-1a, is a potential therapeutic agent for B-lineage malignancies. ( 24547769 )
2014
16
Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A. ( 24760828 )
2014
17
Porcine coronin 1A contributes to nuclear factor-kappa B (NF-κB) inactivation during Haemophilus parasuis infection. ( 25093672 )
2014
18
Coronin 1A inhibits neurite outgrowth in PC12 cells. ( 25179994 )
2014
19
The expanding spectrum of human coronin 1A deficiency. ( 25269405 )
2014
20
Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation. ( 23522482 )
2013
21
Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis. ( 23745754 )
2013
22
Endosomal actin remodeling by coronin-1A controls lipoprotein uptake and degradation in macrophages. ( 22223354 )
2012
23
Coronin-1a inhibits autophagosome formation around Mycobacterium tuberculosis-containing phagosomes and assists mycobacterial survival in macrophages. ( 22256790 )
2012
24
Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. ( 21700422 )
2011
25
Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation. ( 21873980 )
2011
26
GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A. ( 22016387 )
2011
27
Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. ( 20032464 )
2010
28
Mast cell function is not altered by Coronin-1A deficiency. ( 20643816 )
2010
29
Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion. ( 19097825 )
2009
30
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. ( 18836449 )
2008
31
Coronin-1A epigenomics governs mycobacterial persistence in tuberculosis. ( 18031535 )
2008
32
Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. ( 18177666 )
2008
33
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. ( 18199416 )
2008
34
Coronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling. ( 18941544 )
2008
35
Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. ( 17341475 )
2007

Variations for Coronin-1a Deficiency

Expression for Coronin-1a Deficiency

Search GEO for disease gene expression data for Coronin-1a Deficiency.

Pathways for Coronin-1a Deficiency

GO Terms for Coronin-1a Deficiency

Cellular components related to Coronin-1a Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 CORO1A CORO1B CXCR4 NT5C
2 actin filament GO:0005884 9.16 CORO1A CORO1B
3 lamellipodium GO:0030027 9.13 CORO1A CORO1B CORO1C
4 cell leading edge GO:0031252 8.8 CORO1A CORO1B CXCR4

Biological processes related to Coronin-1a Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.26 CORO1A LIG4
2 phagocytosis GO:0006909 9.16 CORO1A CORO1C
3 actin cytoskeleton organization GO:0030036 9.13 CORO1A CORO1B CORO1C
4 positive regulation of lamellipodium morphogenesis GO:2000394 8.62 CORO1B CORO1C

Molecular functions related to Coronin-1a Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament binding GO:0051015 9.13 CORO1A CORO1B CORO1C
2 actin binding GO:0003779 8.92 CORO1A CORO1B CORO1C CXCR4

Sources for Coronin-1a Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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