MCID: CRP003
MIFTS: 35

Corpus Callosum Lipoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Corpus Callosum Lipoma

MalaCards integrated aliases for Corpus Callosum Lipoma:

Name: Corpus Callosum Lipoma 12 15
Lipoma of the Corpus Callosum 12
Lipoma of Corpus Callosum 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6294
NCIt 49 C5438
UMLS 71 C1333160

Summaries for Corpus Callosum Lipoma

MalaCards based summary : Corpus Callosum Lipoma, also known as lipoma of the corpus callosum, is related to lipomatosis, multiple and hemifacial microsomia. An important gene associated with Corpus Callosum Lipoma is ALX3 (ALX Homeobox 3), and among its related pathways/superpathways are Pathways in cancer and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Affiliated tissues include skin, bone and brain, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Corpus Callosum Lipoma

Diseases related to Corpus Callosum Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 lipomatosis, multiple 31.3 NF1 FGFR1 ALX3
2 hemifacial microsomia 30.6 MSX2 FGFR1 ALX3
3 spinal meningioma 29.9 SMARCB1 NF2 NF1
4 cleft lip 29.8 WNT9B WNT3 SHH FGFR1
5 meningioma, familial 29.5 SMARCB1 SHH NF2 NF1
6 cleft palate, isolated 27.6 WNT9B WNT3 SHH PES1 MSX2 LIG3
7 cleft, median, of upper lip with polyps of facial skin and nasal mucosa 12.1
8 pleomorphic lipoma 10.8
9 holoprosencephaly 7 10.4 ZIC2 SIX3
10 central nervous system lipoma 10.4 ZIC2 SIX3 ALX3
11 munchausen by proxy 10.4 APELA ALX3
12 skin granular cell tumor 10.4 NF1 MAP2K1
13 patau syndrome 10.3 ZIC2 SIX3 SHH
14 factitious disorder 10.3 APELA ALX3
15 craniofacial microsomia 10.3
16 headache 10.3
17 holoprosencephaly, recurrent infections, and monocytosis 10.3 SIX3 GLI2
18 melanotic medulloblastoma 10.3 SMARCB1 SHH
19 frontonasal dysplasia 1 10.2
20 encephalocele 10.2
21 seizure disorder 10.2
22 pica disease 10.2 PES1 LIG3
23 microcephaly and chorioretinopathy 1 10.2 PES1 LIG3
24 hemiplegia 10.2
25 cerebellum cancer 10.2 SHH NF1
26 skin lipoma 10.2 NF1 FGFR1
27 cardiofaciocutaneous syndrome 1 10.2 NF1 MAP2K1 LIG3
28 epithelioid malignant peripheral nerve sheath tumor 10.2 SMARCB1 NF1
29 holoprosencephaly 9 10.2 ZIC2 SIX3 GLI2
30 syndromic craniosynostosis 10.2 MSX2 FGFR1
31 epithelioid neurofibroma 10.1 NF2 NF1
32 mayer-rokitansky-kuster-hauser syndrome 10.1 WNT9B SHOX
33 amyloid tumor 10.1 NF2 NF1
34 neurilemmoma of the fifth cranial nerve 10.1 NF2 NF1
35 trigeminal nerve neoplasm 10.1 NF2 NF1
36 plexiform schwannoma 10.1 NF2 NF1
37 small intestine leiomyoma 10.1 NF2 NF1
38 congenital hypopituitarism 10.1 SIX3 SHH GLI2
39 hypopituitarism 10.1 SIX3 SHH GLI2
40 skeletal muscle cancer 10.1 SMARCB1 SHH NF1
41 epidermoid cysts 10.1
42 oculoauriculofrontonasal syndrome 10.1
43 visual epilepsy 10.1
44 skin tag 10.1
45 frontal encephalocele 10.1
46 micronodular basal cell carcinoma 10.1 SHH GLI2
47 orbital cancer 10.1 NF2 NF1
48 hypertelorism 10.1
49 tetralogy of fallot 10.1
50 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1

Graphical network of the top 20 diseases related to Corpus Callosum Lipoma:



Diseases related to Corpus Callosum Lipoma

Symptoms & Phenotypes for Corpus Callosum Lipoma

GenomeRNAi Phenotypes related to Corpus Callosum Lipoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 10.26 MAP2K1
2 Decreased viability GR00221-A-1 10.26 FGFR1 GLI2 NF1 SMARCB1
3 Decreased viability GR00221-A-2 10.26 CHEK2 FGFR1 GLI2 NF1 SMARCB1
4 Decreased viability GR00221-A-3 10.26 CHEK2 SMARCB1 MAP2K1 NF2 SHH
5 Decreased viability GR00221-A-4 10.26 CHEK2 NF1
6 Decreased viability GR00342-S-1 10.26 MAP2K1
7 Decreased viability GR00342-S-2 10.26 CHEK2 MAP2K1
8 Decreased viability GR00342-S-3 10.26 MAP2K1
9 Decreased viability GR00381-A-1 10.26 SMARCB1
10 Decreased viability GR00402-S-2 10.26 CHEK2 FGFR1 GLI2 NF1 SMARCB1 MAP2K1
11 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Corpus Callosum Lipoma:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.43 ALX3 FGFR1 GLI2 LHX8 LIG3 MAP2K1
2 embryo MP:0005380 10.42 ALX3 FGFR1 GLI2 LIG3 MAP2K1 MSX2
3 mortality/aging MP:0010768 10.39 ALX3 CHEK2 FGFR1 GLI2 LHX8 LIG3
4 craniofacial MP:0005382 10.38 ALX3 FGFR1 GLI2 LHX8 MAP2K1 MSX2
5 cellular MP:0005384 10.35 ALX3 CHEK2 FGFR1 GLI2 LHX8 LIG3
6 digestive/alimentary MP:0005381 10.34 ALX3 FGFR1 GLI2 LHX8 MAP2K1 MSX2
7 behavior/neurological MP:0005386 10.32 ALX3 FGFR1 GLI2 LHX8 LIG3 MSX2
8 endocrine/exocrine gland MP:0005379 10.24 ALX3 CHEK2 FGFR1 GLI2 MAP2K1 MSX2
9 nervous system MP:0003631 10.21 ALX3 CHEK2 FGFR1 GLI2 LHX8 LIG3
10 integument MP:0010771 10.15 FGFR1 GLI2 MAP2K1 MSX2 NF1 NF2
11 limbs/digits/tail MP:0005371 10.08 ALX3 FGFR1 GLI2 MSX2 NF1 SHH
12 hearing/vestibular/ear MP:0005377 10.05 FGFR1 GLI2 MAP2K1 MSX2 NF1 NF2
13 reproductive system MP:0005389 10 ALX3 CHEK2 FGFR1 GLI2 MAP2K1 NF1
14 muscle MP:0005369 9.98 FGFR1 GLI2 LIG3 MSX2 NF1 SHH
15 normal MP:0002873 9.92 FGFR1 GLI2 MAP2K1 MSX2 NF1 SHH
16 neoplasm MP:0002006 9.88 CHEK2 MAP2K1 NF1 NF2 SHH SMARCB1
17 respiratory system MP:0005388 9.7 ALX3 GLI2 NF1 NF2 SHH SIX3
18 skeleton MP:0005390 9.65 ALX3 FGFR1 GLI2 MAP2K1 MSX2 NF1
19 vision/eye MP:0005391 9.36 ALX3 FGFR1 GLI2 MAP2K1 MSX2 NF1

Drugs & Therapeutics for Corpus Callosum Lipoma

Search Clinical Trials , NIH Clinical Center for Corpus Callosum Lipoma

Genetic Tests for Corpus Callosum Lipoma

Anatomical Context for Corpus Callosum Lipoma

MalaCards organs/tissues related to Corpus Callosum Lipoma:

40
Skin, Bone, Brain, Spinal Cord, Cerebellum, Skeletal Muscle, Small Intestine

Publications for Corpus Callosum Lipoma

Articles related to Corpus Callosum Lipoma:

(show top 50) (show all 137)
# Title Authors PMID Year
1
Detection of Fetal Corpus Callosum Abnormalities by Means of 3D Ultrasound. 61
26529353 2016
2
A Diagnostic Conundrum: Ectopic Nasal Ossification, Submucosal Alveolar Cleft, Absent Posterior Atlantal Arch, and Corpus Callosum Lipoma. 61
25291089 2015
3
Lipoma of the corpus callosum. 61
25721839 2015
4
[Lipoma of the corpus callosum: about a case with literature review]. 61
26526933 2015
5
Frontal congenital lipoma and lipoma of the corpus callosum in an infant: a case report. 61
24613749 2014
6
A rare cause of generalized seizures: agenesis and Lipoma of the corpus Callosum. 61
25995780 2014
7
Pai syndrome: median cleft lip, corpus callosum lipoma, and fibroepithelial skin tag. 61
24741390 2014
8
Fibrolipoma of the nasal septum; report of the first case. 61
23663503 2013
9
Frontal congenital lipoma. 61
21906151 2012
10
Bilateral redundancy gain and callosal integrity in a man with callosal lipoma: a diffusion-tensor imaging study. 61
21787244 2012
11
Corpus callosum lipoma. 61
22529205 2012
12
[Comments on the published letter to the editor by Martínez-Lapiscina et al: «Epileptic seizure and lipoma of the corpus callosum: cause or finding»]. 61
21453992 2012
13
CNS imaging is a key diagnostic tool in the evaluation of patients with CFC syndrome: two cases and literature review. 61
21337689 2011
14
Lipoma of the corpus callosum and mirror writing. 61
20820006 2010
15
Lipoma of the corpus callosum presenting with an epileptic seizure in an adult. 61
20514943 2010
16
A 58 year old woman with a corpus callosum nodule at autopsy. 61
19744048 2009
17
[Lipoma of the corpus callosum]. 61
18841551 2008
18
Pai syndrome: first patient with agenesis of the corpus callosum and literature review. 61
17803202 2007
19
Antenatal presentation of the oculo-auriculo-vertebral spectrum (OAVS). 61
16761296 2006
20
Lipoma of the Corpus Callosum : Diagnosis Using Magnetic Resonance Imaging. 61
27407919 2006
21
Congenital cranial and spinal dermal sinuses: a report of 3 cases. 61
17050497 2006
22
Pai syndrome (median cleft palate, cutaneous nasal polyp, and midline lipoma of the corpus callosum): a case report and literature review. 61
15927272 2005
23
[Corpus callosum lipoma]. 61
15112452 2004
24
[Lipoma of the corpus callosum associated with the hypertrophy of the corpus callosum: case report]. 61
11018839 2000
25
Frontonasal dysplasia with corpus callosum lipoma. 61
10717702 1999
26
[Lipoma of the corpus callosum]. 61
10399737 1999
27
A case of Pai syndrome. 61
9915178 1999
28
[Curvilinear lipoma of the corpus callosum associated with lipoma of the choroid plexus. Report of a case]. 61
10189931 1998
29
[Lipoma of the corpus callosum in a newborn infant: misinterpretation of cranial ultrasound by coincidence with thrombocytopenia]. 61
9857450 1998
30
Prenatal diagnosis of a fetal intracranial tumor. 61
9697957 1998
31
Prenatal ultrasonographic diagnosis of fetal intracranial tumors: a review. 61
9643639 1998
32
[Lipoma of the corpus callosum]. 61
9757335 1998
33
[Case report of corpus callosum lipoma diagnosed with computer tomography]. 61
9720452 1998
34
Prenatal diagnosis of intracranial lipoma associated with agenesis of the corpus callosum. 61
8677111 1996
35
Frontonasal dysplasia: analysis of 21 cases and literature review. 61
8727576 1996
36
Agenesis and lipoma of corpus callosum. Case report. 61
8585829 1995
37
[Lipoma of the corpus callosum with extracranial extension through frontal bone defect]. 61
8585830 1995
38
Sonographic diagnosis of a corpus callosum lipoma with extracranial extension in an infant. 61
7563303 1995
39
Lipoma of the corpus callosum with frontal encephalocele. 61
29542516 1995
40
A further patient with Pai syndrome with autosomal dominant inheritance? 61
8071979 1994
41
Frontonasal dysplasia, lipoma of the corpus callosum and tetralogy of Fallot. 61
8275566 1993
42
[Lipoma of the corpus callosum. 3 case reports and review of the literature]. 61
8484663 1993
43
Lipoma of the corpus callosum in a neonate: sonographic evaluation. 61
8516045 1993
44
[Sudden death and lipoma of the corpus callosum]. 61
1304166 1992
45
The congenital bregmatic dermoid: an African cyst? 61
1590963 1992
46
Curvilinear and tubulonodular varieties of lipoma of the corpus callosum: an MR and CT study. 61
1885799 1991
47
[Lipoma of the corpus callosum associated with congenital rubella]. 61
1929016 1991
48
Midline dermal sinuses and cysts and their relationship to the central nervous system. 61
1854713 1991
49
Prenatal sonographic diagnosis of lipoma of the corpus callosum in a fetus with Goldenhar syndrome. 61
2006948 1991
50
Lipoma of the corpus callosum associated with frontal and facial anomalies. 61
1803864 1991

Variations for Corpus Callosum Lipoma

Expression for Corpus Callosum Lipoma

Search GEO for disease gene expression data for Corpus Callosum Lipoma.

Pathways for Corpus Callosum Lipoma

GO Terms for Corpus Callosum Lipoma

Cellular components related to Corpus Callosum Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.63 SMARCB1 SIX3 SHOX MSX2 LHX8 ALX3
2 nucleus GO:0005634 9.5 ZIC2 SMARCB1 SIX3 SHOX PES1 NF2
3 nucleolus GO:0005730 9.43 SMARCB1 PES1 NF2 NF1 GLI2 FGFR1

Biological processes related to Corpus Callosum Lipoma according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.23 SIX3 SHOX SHH MSX2 LHX8 CHEK2
2 positive regulation of transcription, DNA-templated GO:0045893 10.08 ZIC2 SHH MAP2K1 GLI2 CHEK2
3 negative regulation of cell proliferation GO:0008285 10.02 SMARCB1 NF2 NF1 MSX2 MAP2K1
4 brain development GO:0007420 9.89 ZIC2 SIX3 NF2 NF1 FGFR1
5 neuron differentiation GO:0030182 9.87 WNT9B WNT3 MAP2K1 LHX8
6 kidney development GO:0001822 9.86 WNT9B SHH GLI2
7 osteoblast differentiation GO:0001649 9.85 NF1 MSX2 GLI2
8 heart development GO:0007507 9.85 SHH NF1 MAP2K1 GLI2 APELA
9 lung development GO:0030324 9.84 SHH GLI2 FGFR1
10 canonical Wnt signaling pathway GO:0060070 9.82 WNT9B WNT3 SHH
11 anterior/posterior pattern specification GO:0009952 9.81 WNT3 SHH MSX2 GLI2
12 regulation of cell proliferation GO:0042127 9.8 SIX3 SHH NF2 NF1 FGFR1
13 cell fate commitment GO:0045165 9.79 WNT9B WNT3 SHH
14 pattern specification process GO:0007389 9.77 SHH GLI2 ALX3
15 embryonic digit morphogenesis GO:0042733 9.77 SHH MSX2 GLI2
16 embryonic limb morphogenesis GO:0030326 9.76 SHH MSX2 FGFR1
17 anatomical structure development GO:0048856 9.73 SIX3 SHH GLI2
18 placenta blood vessel development GO:0060674 9.68 MAP2K1 APELA
19 dorsal/ventral neural tube patterning GO:0021904 9.67 SHH GLI2
20 ectoderm development GO:0007398 9.67 SHH NF2
21 lens fiber cell differentiation GO:0070306 9.66 SIX3 NF2
22 branching involved in salivary gland morphogenesis GO:0060445 9.66 SHH FGFR1
23 limb bud formation GO:0060174 9.65 WNT3 SHH
24 positive regulation of T cell differentiation in thymus GO:0033089 9.65 SHH GLI2
25 mammary gland epithelium development GO:0061180 9.65 WNT3 MSX2
26 branching morphogenesis of an epithelial tube GO:0048754 9.65 WNT9B SHH GLI2
27 regulation of neural precursor cell proliferation GO:2000177 9.64 SIX3 NF2
28 lung-associated mesenchyme development GO:0060484 9.63 SHH FGFR1
29 Bergmann glial cell differentiation GO:0060020 9.63 SHH MAP2K1
30 odontogenesis of dentin-containing tooth GO:0042475 9.62 SHH NF2 LHX8 GLI2
31 regulation of protein localization to nucleus GO:1900180 9.61 SHH NF2
32 telencephalon regionalization GO:0021978 9.61 SIX3 SHH
33 osteoblast development GO:0002076 9.61 SHH MSX2 GLI2
34 spinal cord dorsal/ventral patterning GO:0021513 9.58 SHH GLI2
35 positive regulation of cell differentiation GO:0045597 9.56 SHH NF2 MAP2K1 FGFR1
36 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.55 SHH GLI2
37 hindgut morphogenesis GO:0007442 9.54 SHH GLI2
38 anatomical structure formation involved in morphogenesis GO:0048646 9.54 WNT3 SHH GLI2
39 ventral midline development GO:0007418 9.52 SHH GLI2
40 embryonic forelimb morphogenesis GO:0035115 9.46 WNT3 SHH MSX2 ALX3
41 multicellular organism development GO:0007275 9.32 ZIC2 WNT9B WNT3 SIX3 SHOX SHH
42 embryonic hindlimb morphogenesis GO:0035116 9.26 WNT3 SHH MSX2 ALX3

Molecular functions related to Corpus Callosum Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.81 ZIC2 SMARCB1 SIX3 SHOX MSX2 LIG3
2 sequence-specific DNA binding GO:0043565 9.43 SIX3 SHOX MSX2 LHX8 GLI2 ALX3
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.17 ZIC2 SIX3 SHOX MSX2 LHX8 GLI2

Sources for Corpus Callosum Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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