MCID: CRT005
MIFTS: 27

Cortical Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Cortical Thymoma

MalaCards integrated aliases for Cortical Thymoma:

Name: Cortical Thymoma 12 15
Polygonal Cell Thymoma 12
Thymoma, Cortical 12
Thymoma, Type B2 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6530
NCIt 49 C6888
UMLS 71 C1266095

Summaries for Cortical Thymoma

MalaCards based summary : Cortical Thymoma, also known as polygonal cell thymoma, is related to epithelial malignant thymoma and predominantly cortical thymoma. An important gene associated with Cortical Thymoma is C1orf21 (Chromosome 1 Open Reading Frame 21), and among its related pathways/superpathways are Amoebiasis and Cell cycle Cell cycle (generic schema). Affiliated tissues include thymus, skin and t cells.

Related Diseases for Cortical Thymoma

Diseases related to Cortical Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 epithelial malignant thymoma 30.2 TTN SRRM1
2 predominantly cortical thymoma 12.4
3 thymoma, familial 10.2
4 thymoma 10.2
5 myasthenia gravis 10.1
6 thymic carcinoma 10.0
7 verruciform xanthoma of skin 9.9 CD1E CD1A
8 multifocal motor neuropathy 9.9 CD1E CD1A
9 interstitial pneumonitis, desquamative, familial 9.9 CD1E CD1A
10 thymus lipoma 9.8 CD1B CD1A
11 tetanus 9.8
12 thymic epithelial tumor 9.8
13 thymic epithelial neoplasm 9.8
14 immune system organ benign neoplasm 9.8 CD1B CD1A
15 malignant histiocytosis 9.8 CD1E CD1A
16 lymphatic system cancer 9.8 TTN CD1E
17 mite infestation 9.8 CD1B CD1A
18 leukoplakia 9.7 PCNA KRT13
19 inverted papilloma 9.6 PCNA KRT13
20 malignant histiocytic disease 9.6 CD1E CD1B CD1A
21 mycobacterium malmoense 9.6 CD1E CD1B CD1A
22 central nervous system sarcoma 9.6 CD1E CD1B CD1A
23 lichen nitidus 9.6 CD1E CD1B CD1A
24 precursor lymphoblastic lymphoma/leukemia 9.6 CD1E CD1B CD1A
25 precursor t-lymphoblastic lymphoma/leukemia 9.6 CD1E CD1B CD1A
26 rhinoscleroma 9.6 CD1E CD1B CD1A
27 reticulohistiocytic granuloma 9.6 CD1E CD1B CD1A
28 skin sarcoidosis 9.6 CD1E CD1B CD1A
29 langerhans cell sarcoma 9.6 CD1E CD1B CD1A
30 interdigitating dendritic cell sarcoma 9.6 CD1E CD1B CD1A
31 spongiotic dermatitis 9.6 CD1E CD1B CD1A
32 orbital cancer 9.6 CD1E CD1B CD1A
33 balloon cell malignant melanoma 9.6 CD1E CD1B CD1A
34 granuloma annulare 9.6 CD1E CD1B CD1A
35 inflamed seborrheic keratosis 9.6 CD1E CD1B CD1A
36 oral cancer 9.6 PCNA KRT13
37 histiocytic and dendritic cell cancer 9.6 CD1E CD1B CD1A
38 non-langerhans-cell histiocytosis 9.6 CD1E CD1B CD1A
39 adult xanthogranuloma 9.6 CD1E CD1B CD1A
40 central epithelioid sarcoma 9.6 CD1E CD1B CD1A
41 vulvar proximal-type epithelioid sarcoma 9.6 CD1E CD1B CD1A
42 juvenile xanthogranuloma 9.6 CD1E CD1B CD1A
43 dermis tumor 9.6 CD1E CD1B CD1A
44 polyclonal hypergammaglobulinemia 9.6 CD1E CD1B CD1A
45 erdheim-chester disease 9.6 CD1E CD1B CD1A
46 bone benign neoplasm 9.5 CD1E CD1B CD1A
47 seborrheic dermatitis 9.5 CD1E CD1B CD1A
48 diabetes insipidus, neurohypophyseal 9.5 CD1E CD1B CD1A
49 lichen disease 9.5 CD1E CD1B CD1A
50 exophthalmos 9.5 CD1E CD1B CD1A

Graphical network of the top 20 diseases related to Cortical Thymoma:



Diseases related to Cortical Thymoma

Symptoms & Phenotypes for Cortical Thymoma

Drugs & Therapeutics for Cortical Thymoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label Phase II Study of Regorafenib in Patients With Metastatic Solid Tumors Who Have Progressed After Standard Therapy - RESOUND Unknown status NCT02307500 Phase 2 Regorafenib

Search NIH Clinical Center for Cortical Thymoma

Genetic Tests for Cortical Thymoma

Anatomical Context for Cortical Thymoma

MalaCards organs/tissues related to Cortical Thymoma:

40
Thymus, Skin, T Cells, Lymph Node, Bone

Publications for Cortical Thymoma

Articles related to Cortical Thymoma:

(show all 42)
# Title Authors PMID Year
1
Thymoma mimicking an aortic aneurysm: always expect the unexpected. 61
31320375 2019
2
Ectopic thymoma: report of 2 cases and review of the literature. 61
31933830 2019
3
Mesothelioma With a Large Prevascular Lymph Node: N1 Involvement or Something Different? 61
29355487 2018
4
Histogram analysis of apparent diffusion coefficient maps for assessing thymic epithelial tumours: correlation with world health organization classification and clinical staging. 61
29260882 2018
5
Expression of receptor for advanced glycation end-products (RAGE) in thymus from myasthenia patients. 61
28461027 2017
6
Ectopic thymoma presenting as a large intrathoracic mass. 61
26881626 2015
7
A case of co-existing paraganglioma and thymoma. 61
26543766 2015
8
Associated immunological disorders and cellular immune dysfunction in thymoma: a study of 87 cases from Thailand. 61
23229679 2013
9
Thymoma hyalinized by steroid therapy in myasthenia gravis. 61
22879563 2012
10
Post-thymectomy myasthenia gravis with an episode of Osserman stage III. 61
24960131 2012
11
[Extended thymectomy and intraoperative-intrapleural perfusion hyperthermo-chemotherapy for stage IVa invasive thymoma with myasthenia gravis]. 61
21591443 2011
12
Thymoma in myasthenia gravis: from diagnosis to treatment. 61
21860784 2011
13
Malignant thymoma as etiology of bilateral, biventricular cardiac failure. 61
21954545 2011
14
Successful treatment with cyclosporine of thymoma-related aplastic anemia. 61
17695491 2007
15
Histopatholgical spectrum of thymic neoplasms: twelve-year experience at a referral hospital in north India. 61
16625962 2006
16
Long-term outcome after multimodality treatment for stage III thymic tumors. 61
14667602 2003
17
Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules. 61
12098514 2002
18
Somatostatin receptor subtypes in human thymoma and inhibition of cell proliferation by octreotide in vitro. 61
10770220 2000
19
Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. 61
10705015 2000
20
PE-35-related antigen expression and CD1a-positive lymphocytes in thymoma subtypes based on Müller-Hermelink classification. An immunohistochemical study using catalyzed signal amplification. 61
10664158 2000
21
Evaluation of the malignant grade of thymic epithelial tumors according to the epithelial subclassification. 61
10648082 2000
22
Argyrophilic nucleolar organizer regions in cells of thymoma and thymic carcinoma: correlation with DNA ploidy and clinicopathologic characteristics. 61
10208217 1999
23
Thymomas and thymic carcinomas. Evaluation of the Müller-Hermelink classification. 61
10323079 1998
24
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. 61
9463585 1998
25
Multimodality treatment of thymoma: a prospective study. 61
9436540 1997
26
Oligoclonal peripheral T-cell lymphocytosis as a result of aberrant T-cell development in a cortical thymoma. 61
9360846 1997
27
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. 61
8543314 1996
28
Recurrent thymoma: evidence for histological progression. 61
8575735 1995
29
Immunohistochemical detection of bcl-2 protein in thymoma. 61
8522289 1995
30
The clinicopathological correlation of epithelial subtyping in thymoma: a study of 112 consecutive cases. 61
8088764 1994
31
Evaluation of a histogenetic classification for thymic epithelial tumours. 61
7959642 1994
32
Thymoma. Histologic subclassification is an independent prognostic factor. 61
8033040 1994
33
Distribution of molecules mediating thymocyte-stroma-interactions in human thymus, thymitis and thymic epithelial tumors. 61
7725387 1994
34
Thymoma--morphologic subclassification correlates with invasiveness and immunohistologic features: a study of 122 cases. 61
8253462 1993
35
Thymoma: a study of the pathologic classification of 71 cases with evaluation of the Muller-Hermelink system. 61
8319955 1993
36
Expression of epidermal and nerve growth factor receptors in human thymus and thymomas. 61
8365713 1993
37
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. 61
1463094 1992
38
Well-differentiated thymic carcinoma: a clinico-pathological study. 61
1549907 1992
39
Thymic carcinoma. Report of five cases and review of the literature. 61
2179229 1990
40
Multiple clonal chromosome aberrations in two thymomas. 61
2766255 1989
41
Correlations between histological type, clinical behaviour, and prognosis in thymoma. 61
2763254 1989
42
Thymoma: a clinico-pathologic study based on newly developed morphologic criteria. 61
3354066 1988

Variations for Cortical Thymoma

Expression for Cortical Thymoma

Search GEO for disease gene expression data for Cortical Thymoma.

Pathways for Cortical Thymoma

Pathways related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.34 CD1E CD1B CD1A
2
Show member pathways
11.19 PCNA E2F2
3 11.15 PCNA CD1E CD1B CD1A
4 11.13 CD1E CD1B CD1A

GO Terms for Cortical Thymoma

Cellular components related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD1E CD1B CD1A

Biological processes related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.43 CD1E CD1B CD1A
2 positive regulation of T cell mediated cytotoxicity GO:0001916 9.33 CD1E CD1B CD1A
3 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.13 CD1E CD1B CD1A
4 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.8 CD1E CD1B CD1A

Molecular functions related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.33 CD1E CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.13 CD1E CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 8.8 CD1E CD1B CD1A

Sources for Cortical Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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