MCID: CRT005
MIFTS: 28

Cortical Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Cortical Thymoma

MalaCards integrated aliases for Cortical Thymoma:

Name: Cortical Thymoma 12 15
Polygonal Cell Thymoma 12
Thymoma, Cortical 12
Thymoma, Type B2 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6530
NCIt 50 C6888
UMLS 73 C1266095

Summaries for Cortical Thymoma

MalaCards based summary : Cortical Thymoma, also known as polygonal cell thymoma, is related to predominantly cortical thymoma and dendritic cell thymoma. An important gene associated with Cortical Thymoma is TTN (Titin), and among its related pathways/superpathways are Immune response IFN gamma signaling pathway and Photodynamic therapy-induced NF-kB survival signaling. Affiliated tissues include t cells, pituitary and thymus.

Related Diseases for Cortical Thymoma

Diseases related to Cortical Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 predominantly cortical thymoma 12.3
2 dendritic cell thymoma 10.2 CD58 TTN
3 thymoma 10.1
4 pericoronitis 10.1 CD2 VCAM1
5 prolactin producing pituitary tumor 10.0 NGF SST
6 chylothorax, congenital 10.0 SST VCAM1
7 lethal midline granuloma 10.0 CD2 ICAM1
8 endocrine organ benign neoplasm 10.0 NGF SST
9 thymus cancer 10.0
10 lymphocytic vasculitis 9.9 ICAM1 VCAM1
11 mooren's ulcer 9.9 ICAM1 VCAM1
12 shwartzman phenomenon 9.9 ICAM1 VCAM1
13 subendocardial myocardial infarction 9.9 ICAM1 VCAM1
14 lepromatous leprosy 9.9 CD2 ICAM1
15 brachydactyly, type e2 9.9 ICAM1 VCAM1
16 immune-complex glomerulonephritis 9.9 ICAM1 VCAM1
17 rheumatoid vasculitis 9.9 ICAM1 VCAM1
18 limbal stem cell deficiency 9.9 ICAM1 VCAM1
19 leukostasis 9.9 ICAM1 VCAM1
20 henoch-schoenlein purpura 9.9 ICAM1 VCAM1
21 arteriosclerosis obliterans 9.9 ICAM1 VCAM1
22 chronic venous insufficiency 9.9 ICAM1 VCAM1
23 venous insufficiency 9.9 ICAM1 VCAM1
24 crescentic glomerulonephritis 9.9 ICAM1 VCAM1
25 dengue disease 9.9 ICAM1 VCAM1
26 keratoconjunctivitis 9.9 ICAM1 NGF
27 primary progressive multiple sclerosis 9.9 ICAM1 VCAM1
28 diabetic macular edema 9.9 ICAM1 SST
29 microvascular complications of diabetes 5 9.8 ICAM1 VCAM1
30 epithelial malignant thymoma 9.8
31 thymic epithelial tumor 9.8
32 arteries, anomalies of 9.8 ICAM1 VCAM1
33 oral lichen planus 9.8 CD58 ICAM1 VCAM1
34 trypanosomiasis 9.8 ICAM1 VCAM1
35 rhinitis 9.8 ICAM1 NGF VCAM1
36 allergic rhinitis 9.8 ICAM1 NGF VCAM1
37 synovitis 9.8 ICAM1 VCAM1
38 dermatitis, atopic 9.7 ICAM1 NGF VCAM1
39 microvascular complications of diabetes 1 9.7 ICAM1 SST VCAM1
40 multiple sclerosis 9.7 ICAM1 NGF VCAM1
41 proteasome-associated autoinflammatory syndrome 1 9.7 ICAM1 VCAM1
42 actinic prurigo 9.7 CD2 CD58 ICAM1 VCAM1

Graphical network of the top 20 diseases related to Cortical Thymoma:



Diseases related to Cortical Thymoma

Symptoms & Phenotypes for Cortical Thymoma

Drugs & Therapeutics for Cortical Thymoma

Search Clinical Trials , NIH Clinical Center for Cortical Thymoma

Genetic Tests for Cortical Thymoma

Anatomical Context for Cortical Thymoma

MalaCards organs/tissues related to Cortical Thymoma:

41
T Cells, Pituitary, Thymus

Publications for Cortical Thymoma

Articles related to Cortical Thymoma:

# Title Authors Year
1
Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules. ( 12098514 )
2002
2
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. ( 9463585 )
1998
3
Oligoclonal peripheral T-cell lymphocytosis as a result of aberrant T-cell development in a cortical thymoma. ( 9360846 )
1997
4
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. ( 1463094 )
1992

Variations for Cortical Thymoma

Expression for Cortical Thymoma

Search GEO for disease gene expression data for Cortical Thymoma.

Pathways for Cortical Thymoma

GO Terms for Cortical Thymoma

Cellular components related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD2 ICAM1 VCAM1
2 cell surface GO:0009986 8.92 CD2 CD58 ICAM1 VCAM1

Biological processes related to Cortical Thymoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to nutrient GO:0007584 9.51 SST VCAM1
2 leukocyte migration GO:0050900 9.5 CD2 CD58 ICAM1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.49 ICAM1 VCAM1
4 response to ionizing radiation GO:0010212 9.48 ICAM1 VCAM1
5 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.46 ICAM1 VCAM1
6 response to amino acid GO:0043200 9.43 ICAM1 SST
7 leukocyte cell-cell adhesion GO:0007159 9.4 ICAM1 VCAM1
8 heterotypic cell-cell adhesion GO:0034113 9.37 CD2 CD58
9 cellular response to tumor necrosis factor GO:0071356 9.33 CD58 ICAM1 VCAM1
10 positive regulation of interleukin-8 secretion GO:2000484 9.26 CD2 CD58
11 membrane to membrane docking GO:0022614 8.96 ICAM1 VCAM1
12 cell-cell adhesion GO:0098609 8.92 CD2 CD58 ICAM1 VCAM1

Molecular functions related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.8 CD2 CD58 NGF

Sources for Cortical Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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