MCID: CRT005
MIFTS: 30

Cortical Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Cortical Thymoma

MalaCards integrated aliases for Cortical Thymoma:

Name: Cortical Thymoma 12 15
Polygonal Cell Thymoma 12
Thymoma, Cortical 12
Thymoma, Type B2 74

Classifications:



External Ids:

Disease Ontology 12 DOID:6530
NCIt 51 C6888
UMLS 74 C1266095

Summaries for Cortical Thymoma

MalaCards based summary : Cortical Thymoma, also known as polygonal cell thymoma, is related to thymoma and predominantly cortical thymoma. An important gene associated with Cortical Thymoma is TTN (Titin), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include t cells, pituitary and thymus.

Related Diseases for Cortical Thymoma

Diseases related to Cortical Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 thymoma 30.5 CD2 CTLA4 TTN
2 predominantly cortical thymoma 12.3
3 dendritic cell thymoma 10.4 CD58 TTN
4 pericoronitis 10.3 CD2 VCAM1
5 multifocal motor neuropathy 10.3 CD1A CD1E
6 lethal midline granuloma 10.3 CD2 ICAM1
7 lymphocytic vasculitis 10.2 ICAM1 VCAM1
8 mooren's ulcer 10.2 ICAM1 VCAM1
9 prolactin producing pituitary tumor 10.2 NGF SST
10 shwartzman phenomenon 10.2 ICAM1 VCAM1
11 chylothorax, congenital 10.2 SST VCAM1
12 orbital plasma cell granuloma 10.2 CTLA4 SST
13 subendocardial myocardial infarction 10.2 ICAM1 VCAM1
14 brachydactyly, type e2 10.2 ICAM1 VCAM1
15 immune-complex glomerulonephritis 10.2 ICAM1 VCAM1
16 rheumatoid vasculitis 10.2 ICAM1 VCAM1
17 limbal stem cell deficiency 10.1 ICAM1 VCAM1
18 thymoma, familial 10.1
19 leukostasis 10.1 ICAM1 VCAM1
20 oral lichen planus 10.1 CD58 ICAM1 VCAM1
21 henoch-schoenlein purpura 10.1 ICAM1 VCAM1
22 rhinitis 10.1 ICAM1 NGF VCAM1
23 arteriosclerosis obliterans 10.0 ICAM1 VCAM1
24 microvascular complications of diabetes 1 10.0 ICAM1 SST VCAM1
25 allergic rhinitis 10.0 ICAM1 NGF VCAM1
26 sezary's disease 10.0 CD2 CD28 CTLA4
27 chronic venous insufficiency 10.0 ICAM1 VCAM1
28 thymic carcinoma 10.0
29 actinic prurigo 10.0 CD2 CD58 ICAM1 VCAM1
30 thymus lipoma 9.8 CD1A CD1B CD1C
31 immune system organ benign neoplasm 9.8 CD1A CD1B CD1C
32 epithelial malignant thymoma 9.8
33 thymic epithelial tumor 9.8
34 diabetic macular edema 9.8 ICAM1 SST
35 rheumatoid arthritis 9.6 CD28 CTLA4 ICAM1 VCAM1
36 mycobacterium malmoense 9.2 CD1A CD1B CD1C CD1D CD1E

Graphical network of the top 20 diseases related to Cortical Thymoma:



Diseases related to Cortical Thymoma

Symptoms & Phenotypes for Cortical Thymoma

Drugs & Therapeutics for Cortical Thymoma

Search Clinical Trials , NIH Clinical Center for Cortical Thymoma

Genetic Tests for Cortical Thymoma

Anatomical Context for Cortical Thymoma

MalaCards organs/tissues related to Cortical Thymoma:

42
T Cells, Pituitary, Thymus

Publications for Cortical Thymoma

Articles related to Cortical Thymoma:

# Title Authors Year
1
Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules. ( 12098514 )
2002
2
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. ( 9463585 )
1998
3
Oligoclonal peripheral T-cell lymphocytosis as a result of aberrant T-cell development in a cortical thymoma. ( 9360846 )
1997
4
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. ( 1463094 )
1992

Variations for Cortical Thymoma

Expression for Cortical Thymoma

Search GEO for disease gene expression data for Cortical Thymoma.

Pathways for Cortical Thymoma

GO Terms for Cortical Thymoma

Cellular components related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.76 CD1B CD1C CD1D CD1E
2 endosome membrane GO:0010008 9.67 CD1A CD1B CD1C CD1D
3 external side of plasma membrane GO:0009897 9.65 CD2 CD28 CTLA4 ICAM1 VCAM1
4 integral component of plasma membrane GO:0005887 9.65 CD1A CD1C CD1D CD1E CD2 CD28
5 endosome GO:0005768 9.55 CD1A CD1B CD1C CD1D CD1E
6 immunological synapse GO:0001772 9.48 CD28 ICAM1
7 protein complex involved in cell adhesion GO:0098636 9.32 CD28 CTLA4
8 cell surface GO:0009986 9.17 CD1B CD1D CD2 CD28 CD58 ICAM1
9 integral component of membrane GO:0016021 10.17 CD1A CD1B CD1C CD1D CD1E CD2
10 plasma membrane GO:0005886 10.14 CD1A CD1B CD1C CD1D CD1E CD2

Biological processes related to Cortical Thymoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.91 CD1A CD1B CD1C CD1D CD1E CTLA4
2 immune response GO:0006955 9.87 CD1A CD1B CD1C CD1D CD1E CD28
3 adaptive immune response GO:0002250 9.8 CD1A CD1B CD1C CD1E CTLA4
4 cell-cell adhesion GO:0098609 9.76 CD2 CD58 ICAM1 VCAM1
5 leukocyte migration GO:0050900 9.73 CD2 CD58 ICAM1
6 regulation of immune response GO:0050776 9.73 CD1A CD1B CD1C CD1D ICAM1 VCAM1
7 cellular response to tumor necrosis factor GO:0071356 9.71 CD58 ICAM1 VCAM1
8 positive regulation of T cell proliferation GO:0042102 9.67 CD1D CD28 VCAM1
9 response to amino acid GO:0043200 9.57 ICAM1 SST
10 leukocyte cell-cell adhesion GO:0007159 9.55 ICAM1 VCAM1
11 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1A CD1B CD1C CD1D CD1E
12 heterotypic cell-cell adhesion GO:0034113 9.54 CD1D CD2 CD58
13 regulation of regulatory T cell differentiation GO:0045589 9.52 CD28 CTLA4
14 positive regulation of interleukin-8 secretion GO:2000484 9.51 CD2 CD58
15 membrane to membrane docking GO:0022614 9.48 ICAM1 VCAM1
16 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1A CD1B CD1C CD1D CD1E
17 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1A CD1B CD1C CD1D CD1E

Molecular functions related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1A CD1B CD1C CD1D CD1E
2 endogenous lipid antigen binding GO:0030883 9.35 CD1A CD1B CD1C CD1D CD1E
3 exogenous lipid antigen binding GO:0030884 9.02 CD1A CD1B CD1C CD1D CD1E

Sources for Cortical Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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