MCID: CRT005
MIFTS: 23

Cortical Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Cortical Thymoma

MalaCards integrated aliases for Cortical Thymoma:

Name: Cortical Thymoma 12 15
Polygonal Cell Thymoma 12
Thymoma, Cortical 12
Thymoma, Type B2 72

Classifications:



External Ids:

Disease Ontology 12 DOID:6530
NCIt 50 C6888
UMLS 72 C1266095

Summaries for Cortical Thymoma

MalaCards based summary : Cortical Thymoma, also known as polygonal cell thymoma, is related to predominantly cortical thymoma and thymoma, familial. An important gene associated with Cortical Thymoma is TTN (Titin), and among its related pathways/superpathways is Retinoblastoma (RB) in Cancer. Affiliated tissues include thymus, t cells and lymph node, and related phenotype is Increased cell death HMECs cells.

Related Diseases for Cortical Thymoma

Diseases related to Cortical Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 predominantly cortical thymoma 12.4
2 thymoma, familial 10.2
3 thymoma 10.2
4 myasthenia gravis 10.1
5 thymic carcinoma 10.0
6 epithelial malignant thymoma 10.0
7 leukoplakia 9.9 PCNA KRT13
8 dendritic cell thymoma 9.9 TTN CD58
9 inverted papilloma 9.9 PCNA KRT13
10 tetanus 9.8
11 thymic epithelial tumor 9.8
12 thymic epithelial neoplasm 9.8
13 papilloma 9.8 PCNA KRT13
14 oral cancer 9.7 PCNA KRT13
15 mucoepidermoid carcinoma 9.5 PCNA KRT13

Graphical network of the top 20 diseases related to Cortical Thymoma:



Diseases related to Cortical Thymoma

Symptoms & Phenotypes for Cortical Thymoma

GenomeRNAi Phenotypes related to Cortical Thymoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 8.8 KRT13 PCNA TTN

Drugs & Therapeutics for Cortical Thymoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label Phase II Study of Regorafenib in Patients With Metastatic Solid Tumors Who Have Progressed After Standard Therapy - RESOUND Active, not recruiting NCT02307500 Phase 2 Regorafenib

Search NIH Clinical Center for Cortical Thymoma

Genetic Tests for Cortical Thymoma

Anatomical Context for Cortical Thymoma

MalaCards organs/tissues related to Cortical Thymoma:

41
Thymus, T Cells, Lymph Node

Publications for Cortical Thymoma

Articles related to Cortical Thymoma:

(show all 41)
# Title Authors PMID Year
1
Thymoma mimicking an aortic aneurysm: always expect the unexpected. 38
31320375 2019
2
Mesothelioma With a Large Prevascular Lymph Node: N1 Involvement or Something Different? 38
29355487 2018
3
Histogram analysis of apparent diffusion coefficient maps for assessing thymic epithelial tumours: correlation with world health organization classification and clinical staging. 38
29260882 2018
4
Expression of receptor for advanced glycation end-products (RAGE) in thymus from myasthenia patients. 38
28461027 2017
5
Ectopic thymoma presenting as a large intrathoracic mass. 38
26881626 2015
6
A case of co-existing paraganglioma and thymoma. 38
26543766 2015
7
Associated immunological disorders and cellular immune dysfunction in thymoma: a study of 87 cases from Thailand. 38
23229679 2013
8
Thymoma hyalinized by steroid therapy in myasthenia gravis. 38
22879563 2012
9
Post-thymectomy myasthenia gravis with an episode of Osserman stage III. 38
24960131 2012
10
[Extended thymectomy and intraoperative-intrapleural perfusion hyperthermo-chemotherapy for stage IVa invasive thymoma with myasthenia gravis]. 38
21591443 2011
11
Thymoma in myasthenia gravis: from diagnosis to treatment. 38
21860784 2011
12
Malignant thymoma as etiology of bilateral, biventricular cardiac failure. 38
21954545 2011
13
Successful treatment with cyclosporine of thymoma-related aplastic anemia. 38
17695491 2007
14
Histopatholgical spectrum of thymic neoplasms: twelve-year experience at a referral hospital in north India. 38
16625962 2006
15
Long-term outcome after multimodality treatment for stage III thymic tumors. 38
14667602 2003
16
Titin and ryanodine receptor epitopes are expressed in cortical thymoma along with costimulatory molecules. 38
12098514 2002
17
Somatostatin receptor subtypes in human thymoma and inhibition of cell proliferation by octreotide in vitro. 38
10770220 2000
18
Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. 38
10705015 2000
19
PE-35-related antigen expression and CD1a-positive lymphocytes in thymoma subtypes based on Müller-Hermelink classification. An immunohistochemical study using catalyzed signal amplification. 38
10664158 2000
20
Evaluation of the malignant grade of thymic epithelial tumors according to the epithelial subclassification. 38
10648082 2000
21
Argyrophilic nucleolar organizer regions in cells of thymoma and thymic carcinoma: correlation with DNA ploidy and clinicopathologic characteristics. 38
10208217 1999
22
Thymomas and thymic carcinomas. Evaluation of the Müller-Hermelink classification. 38
10323079 1998
23
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. 38
9463585 1998
24
Multimodality treatment of thymoma: a prospective study. 38
9436540 1997
25
Oligoclonal peripheral T-cell lymphocytosis as a result of aberrant T-cell development in a cortical thymoma. 38
9360846 1997
26
Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies. 38
8543314 1996
27
Recurrent thymoma: evidence for histological progression. 38
8575735 1995
28
Immunohistochemical detection of bcl-2 protein in thymoma. 38
8522289 1995
29
The clinicopathological correlation of epithelial subtyping in thymoma: a study of 112 consecutive cases. 38
8088764 1994
30
Evaluation of a histogenetic classification for thymic epithelial tumours. 38
7959642 1994
31
Thymoma. Histologic subclassification is an independent prognostic factor. 38
8033040 1994
32
Distribution of molecules mediating thymocyte-stroma-interactions in human thymus, thymitis and thymic epithelial tumors. 38
7725387 1994
33
Thymoma--morphologic subclassification correlates with invasiveness and immunohistologic features: a study of 122 cases. 38
8253462 1993
34
Thymoma: a study of the pathologic classification of 71 cases with evaluation of the Muller-Hermelink system. 38
8319955 1993
35
Expression of epidermal and nerve growth factor receptors in human thymus and thymomas. 38
8365713 1993
36
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. 38
1463094 1992
37
Well-differentiated thymic carcinoma: a clinico-pathological study. 38
1549907 1992
38
Thymic carcinoma. Report of five cases and review of the literature. 38
2179229 1990
39
Multiple clonal chromosome aberrations in two thymomas. 38
2766255 1989
40
Correlations between histological type, clinical behaviour, and prognosis in thymoma. 38
2763254 1989
41
Thymoma: a clinico-pathologic study based on newly developed morphologic criteria. 38
3354066 1988

Variations for Cortical Thymoma

Expression for Cortical Thymoma

Search GEO for disease gene expression data for Cortical Thymoma.

Pathways for Cortical Thymoma

Pathways related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.57 PCNA E2F2

GO Terms for Cortical Thymoma

Cellular components related to Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 8.92 TTN PCNA KRT13 CD58

Sources for Cortical Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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