CBGD
MCID: CRT033
MIFTS: 55

Corticobasal Degeneration (CBGD)

Categories: Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Corticobasal Degeneration

MalaCards integrated aliases for Corticobasal Degeneration:

Name: Corticobasal Degeneration 52 53 29 71
Corticobasal Syndrome 52 58 6
Cortical-Basal Ganglionic Degeneration 52
Cortico-Basal Ganglionic Degeneration 52
Cbgd 52

Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Corticobasal Degeneration

NINDS : 53 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement),disequilibrium (impaired balance); and limb dystonia (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, myoclonus (muscular jerks), and dysphagia (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary : Corticobasal Degeneration, also known as corticobasal syndrome, is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and leukoencephalopathy, hereditary diffuse, with spheroids. An important gene associated with Corticobasal Degeneration is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Human cytomegalovirus infection and NFAT and Cardiac Hypertrophy. The drugs Iodine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are parkinsonism and progressive extrapyramidal muscular rigidity

NIH Rare Diseases : 52 Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known. Treatment depends on the symptoms in each person. People with corticobasal degeneration usually do not survive beyond an average of 7 years after symptoms begin. Aspiration pneumonia or other complications are usually the cause of death.

Wikipedia : 74 Corticobasal degeneration (CBD) is a rare, neurodegenerative disease involving the cerebral cortex and... more...

Related Diseases for Corticobasal Degeneration

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 33.2 RPS27A MAPT
2 leukoencephalopathy, hereditary diffuse, with spheroids 32.9 RPS27A MAPT CRYAB
3 semantic dementia 32.6 TARDBP RPS27A MAPT
4 supranuclear palsy, progressive, 1 32.1 TARDBP RPS27A MOBP MAPT LRRK2
5 pick disease of brain 31.9 TARDBP RPS27A MOBP MAPT LRRK2 CRYAB
6 frontotemporal dementia 31.7 TARDBP RPS27A MOBP MAPT LRRK2 CRYAB
7 tremor 31.2 MAPT LRRK2 GBA
8 aphasia 31.2 TARDBP MAPT LRRK2
9 multiple system atrophy 1 31.1 RPS27A MAPT LRRK2
10 ideomotor apraxia 31.0 TARDBP MAPT
11 agraphia 30.4 TARDBP MAPT
12 movement disease 30.4 TARDBP MAPT LRRK2 GBA
13 rem sleep behavior disorder 30.4 RPS27A MAPT LRRK2 GBA
14 dysgraphia 30.3 TARDBP MAPT
15 akinetic mutism 30.1 TARDBP MAPT
16 dementia 30.1 UCHL1 TARDBP RPS27A MAPT LRRK2 GBA
17 motor neuron disease 30.1 UCHL1 TARDBP RPS27A MAPT
18 essential tremor 30.1 MAPT LRRK2 GBA
19 postencephalitic parkinson disease 29.9 TARDBP MAPT LRRK2
20 nominal aphasia 29.9 TARDBP MAPT
21 autosomal dominant cerebellar ataxia 29.7 TARDBP RPS27A MAPT LRRK2
22 parkinson disease, late-onset 29.4 UCHL1 RPS27A PITX3 MTOR MAPT LRRK2
23 dementia, lewy body 29.2 UCHL1 TARDBP RPS27A MAPT LRRK2 GBA
24 amyotrophic lateral sclerosis 1 29.1 UCHL1 TARDBP RPS27A MAPT LRRK2 HSPB2
25 alzheimer disease 29.1 UCHL1 TARDBP RPS6KB1 RPS27A MTOR MAPT
26 progressive supranuclear palsy-corticobasal syndrome 12.4
27 obsolete: corticobasal degeneration 12.4
28 apraxia 11.0
29 myoclonus 10.9
30 dystonia 10.8
31 cerebral cortical dysplasia 10.5 RPS27A MAPT
32 cerebral atrophy 10.5
33 creutzfeldt-jakob disease 10.4
34 argyria 10.4
35 hodgkin's paragranuloma 10.4 UCHL1 CSF3
36 dysphagia 10.4
37 spasticity 10.4
38 kearns-sayre syndrome 10.3
39 mutism 10.3
40 focal dystonia 10.3
41 lateral sclerosis 10.3
42 progressive non-fluent aphasia 10.3
43 rare neurodegenerative disease 10.3
44 parkinson disease 3, autosomal dominant 10.3 MAPT LRRK2
45 hereditary late-onset parkinson disease 10.3 LRRK2 GBA
46 ataxia and polyneuropathy, adult-onset 10.3
47 early-onset posterior polar cataract 10.2 PITX3 CRYAB
48 respiratory failure 10.2
49 posterior cortical atrophy 10.2
50 gait apraxia 10.2

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to Corticobasal Degeneration

Symptoms & Phenotypes for Corticobasal Degeneration

Human phenotypes related to Corticobasal Degeneration:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 parkinsonism 58 31 hallmark (90%) Very frequent (99-80%) HP:0001300
2 progressive extrapyramidal muscular rigidity 58 31 hallmark (90%) Very frequent (99-80%) HP:0007158
3 gait disturbance 58 31 frequent (33%) Frequent (79-30%) HP:0001288
4 tremor 58 31 frequent (33%) Frequent (79-30%) HP:0001337
5 dementia 58 31 frequent (33%) Frequent (79-30%) HP:0000726
6 bradykinesia 58 31 frequent (33%) Frequent (79-30%) HP:0002067
7 sensory impairment 58 31 frequent (33%) Frequent (79-30%) HP:0003474
8 postural instability 58 31 frequent (33%) Frequent (79-30%) HP:0002172
9 akinesia 58 31 frequent (33%) Frequent (79-30%) HP:0002304
10 limb myoclonus 58 31 frequent (33%) Frequent (79-30%) HP:0045084
11 limb dystonia 58 31 frequent (33%) Frequent (79-30%) HP:0002451
12 limb apraxia 58 31 frequent (33%) Frequent (79-30%) HP:0030217
13 frontal release signs 58 31 frequent (33%) Frequent (79-30%) HP:0000743
14 oromotor apraxia 58 31 frequent (33%) Frequent (79-30%) HP:0007301
15 dysphasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002357
16 memory impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0002354
17 aphasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002381
18 speech apraxia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011098
19 behavioral abnormality 58 31 very rare (1%) Very rare (<4-1%) HP:0000708
20 myoclonus 58 Very frequent (99-80%)
21 abnormality of movement 58 Very rare (<4-1%)
22 dystonia 58 Occasional (29-5%)
23 involuntary movements 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.02 MTOR RPS6KB1
2 Decreased viability with paclitaxel GR00179-A-2 9.02 MTOR
3 Decreased viability with paclitaxel GR00179-A-3 9.02 MTOR RPS6KB1

MGI Mouse Phenotypes related to Corticobasal Degeneration:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.27 CFL1 CRYAB GBA HSPB2 LRRK2 MAPT
2 cellular MP:0005384 10.27 CFL1 CRYAB GBA HSPB2 LRRK2 MAPT
3 cardiovascular system MP:0005385 10.26 CFL1 GBA HSPB2 LRRK2 MAPT MTOR
4 homeostasis/metabolism MP:0005376 10.25 CFL1 CRYAB GBA KIF13B LRRK2 MAPT
5 hematopoietic system MP:0005397 10.17 CSF3 GBA LRRK2 MAPT MTOR PITX3
6 immune system MP:0005387 10.11 CSF3 GBA LRRK2 MAPT MTOR PITX3
7 integument MP:0010771 9.97 CFL1 CSF3 GBA LRRK2 MAPT PITX3
8 nervous system MP:0003631 9.93 CFL1 GBA LRRK2 MAPT MOBP MTOR
9 muscle MP:0005369 9.86 CRYAB MAPT MTOR ROCK1 ROCK2 RPS6KB1
10 no phenotypic analysis MP:0003012 9.5 CFL1 KIF13B LRRK2 MAPT MTOR PITX3
11 renal/urinary system MP:0005367 9.17 CFL1 CSF3 LRRK2 MAPT MTOR ROCK1

Drugs & Therapeutics for Corticobasal Degeneration

Drugs for Corticobasal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4 7553-56-2 807
2 Pharmaceutical Solutions Phase 4
3 Calamus Phase 4
4 cadexomer iodine Phase 4
5
Pimavanserin Approved, Investigational Phase 3 706779-91-1 16058810
6
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 2, Phase 3 303-98-0 5281915
7 Vitamins Phase 2, Phase 3
8 Trace Elements Phase 2, Phase 3
9 Nutrients Phase 2, Phase 3
10 Micronutrients Phase 2, Phase 3
11 Ubiquinone Phase 2, Phase 3
12 Central Nervous System Depressants Phase 3
13 Tranquilizing Agents Phase 3
14 Psychotropic Drugs Phase 3
15 Antipsychotic Agents Phase 3
16 Serotonin 5-HT2 Receptor Antagonists Phase 3
17 Antiparkinson Agents Phase 3
18 Serotonin Agents Phase 3
19 Serotonin Antagonists Phase 3
20
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
21
Lithium carbonate Approved Phase 1, Phase 2 554-13-2
22
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
23
Memantine Approved, Investigational Phase 2 19982-08-2 4054
24
Carvedilol Approved, Investigational Phase 2 72956-09-3 2585
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
26
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
27 Antimanic Agents Phase 1, Phase 2
28 Antidepressive Agents Phase 1, Phase 2
29 Fluorodeoxyglucose F18 Phase 2
30 Radiopharmaceuticals Phase 2
31 Dopamine Agents Phase 2
32 Excitatory Amino Acid Antagonists Phase 2
33 Excitatory Amino Acids Phase 2
34 Neurotransmitter Agents Phase 2
35 Antihypertensive Agents Phase 2
36 Adrenergic Antagonists Phase 2
37 retinol Phase 2
38 Adrenergic alpha-Antagonists Phase 2
39 Antioxidants Phase 2
40 Adrenergic beta-Antagonists Phase 2
41 Vasodilator Agents Phase 2
42 Retinol palmitate Phase 2
43 Protective Agents Phase 2
44 Calcium, Dietary Phase 2
45 calcium channel blockers Phase 2
46 Adrenergic Agents Phase 2
47 Hormones Phase 2
48 taxane Phase 1
49 Antibodies, Monoclonal Phase 1
50 Immunoglobulins Phase 1

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech Recruiting NCT01818661 Phase 4 AV-1451
2 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
3 Effects of Coenzyme Q10 in PSP and CBD, A Randomized, Placebo-Controlled, Double Blind Cross Over Pilot Study Completed NCT00532571 Phase 2, Phase 3 CoQ10
4 A Double-blind, Placebo-controlled, Relapse Prevention Study of Pimavanserin for the Treatment of Hallucinations and Delusions Associated With Dementia-related Psychosis Completed NCT03325556 Phase 3 Placebo;Pimavanserin 34 mg;Pimavanserin 20 mg
5 Novel Neuroimage Study in Tauopathies With Parkinsonism Unknown status NCT03386669 Phase 2 F-18
6 A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration Completed NCT00703677 Phase 1, Phase 2 Lithium
7 The Differential Diagnosis of Parkinson's Disease and Parkinsonism by Positron-emission Tomography With Vesicular Monoamine Transporter Ligand (18F-DTBZ) Completed NCT01824056 Phase 2 18F-FDG
8 Direct Current Brain Polarization for Apraxia in Corticobasal Syndrome Completed NCT00273897 Phase 2
9 Double-blind, Parallel Group, Placebo-controlled Trial of the Efficacy and Tolerability of Memantine (20 mg) in Frontotemporal Dementia (FTD) Patients Completed NCT00200538 Phase 2 memantine
10 The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease Recruiting NCT03775096 Phase 2 Carvedilol
11 18F-AV-1451 Injection for Brain Imaging of Tau in Subjects With Progressive Supranuclear Palsy (PSP), Subjects With Corticobasal Degeneration (CBD) and Healthy Volunteers" Completed NCT02167594 Phase 1 18F-AV-1451;florbetapir F18
12 A 12 Week Randomized, Double Blind, Placebo-Controlled Pilot Study of Davunetide (NAP, AL-108) in Predicted Tauopathies Completed NCT01056965 Phase 1 davunetide (AL-108, NAP);Placebo nasal spray
13 Alzheimer's PET Imaging in Racially/Ethnically Diverse Adults Recruiting NCT03706261 Phase 1 18F-MK-6240;18F-Florbetaben
14 A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Sequential Cohort, Dose-Ranging Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of TPI 287 in Patients With Primary Four Repeat Tauopathies: Corticobasal Syndrome or Progressive Supranuclear Palsy Active, not recruiting NCT02133846 Phase 1 TPI 287 2 mg/m2;TPI-287 20 mg/m2;Placebo;TPI-287 6.3 mg/m2
15 A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients With Four Different Primary Tauopathy Syndromes Terminated NCT03658135 Phase 1 BIIB092
16 Observational Study Assessing the Diagnostic Contribution of 3-Tesla MRI, CSF Analysis and a Second Opinion in a Specialized Movement Disorder Centre, in Differentiating Between Parkinson's Disease and Atypical Parkinsonism Unknown status NCT01249768
17 Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and Personalized Unknown status NCT01403519
18 Noninvasive Cortical Stimulation (rTMS) for Motor and Non-Motor Features of Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD) Completed NCT01174771
19 Effect of Task on Oral Pressure Dynamics During Swallowing Completed NCT00013832
20 The Four-Repeat Tauopathy Neuroimaging Initiative Recruiting NCT02966145
21 Human CNS Tau Kinetics in Tauopathies Recruiting NCT03545126
22 Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders Recruiting NCT03299062
23 Multimodal Assessment For Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration Recruiting NCT02964637
24 Assessing Changes in Social Cognition and Personality in Patients With Frontotemporal Lobar Degeneration, Alzheimer's Disease and Parkinson's Disease and Their Effect on the Patient-caregiver Relationship Recruiting NCT02964611
25 Rare Diseases Clinical Research Network Advancing Research and Treatment for Frontotemporal Lobar Degeneration [ARTFL]: Research Projects 1 & 2 Recruiting NCT02365922
26 Positron Emission Tomography (PET) Imaging of Tau Pathology in Neurodegenerative Disease Recruiting NCT03143374
27 Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Recruiting NCT03225144
28 More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease Recruiting NCT03076671
29 CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease Recruiting NCT03938870
30 Observational Longitudinal Study of Magnetic Resonance Imaging, Specimen Biomarkers, and Clinical Progression in Progressive Supranuclear Palsy and Corticobasal Degeneration Active, not recruiting NCT01804452
31 PDx Biomarker Assay Study for the Diagnosis of Parkinson's Disease Active, not recruiting NCT02283073
32 Defining Cognitive and Motor Phenotypes of Parkinson's Disease (PD) With Magnetoencephalography Active, not recruiting NCT02132052
33 Vaccination Uptake in Parkinson's Disease Active, not recruiting NCT02874274
34 Expanded Access to ABBV-8E12 No longer available NCT03744546 ABBV-8E12
35 Regional Cerebral Utilization of Glucose in Patients With a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders Terminated NCT00001178

Search NIH Clinical Center for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

Genetic tests related to Corticobasal Degeneration:

# Genetic test Affiliating Genes
1 Corticobasal Degeneration 29

Anatomical Context for Corticobasal Degeneration

MalaCards organs/tissues related to Corticobasal Degeneration:

40
Brain, Cortex, Testes, T Cells, Eye, Spinal Cord, Temporal Lobe

Publications for Corticobasal Degeneration

Articles related to Corticobasal Degeneration:

(show top 50) (show all 1857)
# Title Authors PMID Year
1
Chameleons and mimics: Progressive supranuclear palsy and corticobasal degeneration. 61
31515852 2020
2
Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. 61
31826239 2020
3
Clinical Phenotypes in Corticobasal Syndrome with or without Amyloidosis Biomarkers. 61
32039846 2020
4
Update on posterior cortical atrophy. 61
31688098 2020
5
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. 61
32032505 2020
6
Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases. 61
31498507 2020
7
"Tau Protein Targeting Via Radioiodinated Azure A For Brain Theranostics: Radiolabeling, Molecular Docking, in vitro And in vivo Biological Evaluation". 61
31785209 2020
8
Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates. 61
31950334 2020
9
Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia. 61
31919566 2020
10
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. 61
31616982 2020
11
Incidence and Trends of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Population-Based Study. 61
31594251 2020
12
Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy. 61
31925842 2020
13
Levodopa-responsive parkinsonism in a patient with corticobasal degeneration and bilateral choroid plexus xanthogranulomas. 61
31537463 2020
14
Corrigendum to "Persistence of limb dystonia and myoclonus during sleep in corticobasal syndrome: a case series" [Sleep Med 59 (2019) 107-109]. 61
32008888 2020
15
Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies. 61
31847513 2020
16
Is There a Shared Etiology of Olfactory Impairments in Normal Aging and Neurodegenerative Disease? 61
31744002 2020
17
Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies. 61
31571273 2020
18
Aberrant Accumulation of BRCA1 in Alzheimer Disease and Other Tauopathies. 61
31750914 2020
19
Automated Brainstem Segmentation Detects Differential Involvement in Atypical Parkinsonian Syndromes. 61
31552724 2020
20
Evidence of corticofugal tau spreading in patients with frontotemporal dementia. 61
31542807 2020
21
Acquired Hemicerebral Atrophy Secondary to Chronic Internal Carotid Steno-Occlusive Disease: A Case Series. 61
31839863 2020
22
[Clinical and neuroimaging features in 6 patients with corticobasal syndrome]. 61
31775454 2019
23
Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants. 61
31935638 2019
24
High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study. 61
31882022 2019
25
Disentangling brain functional network remodeling in corticobasal syndrome - A multimodal MRI study. 61
31821953 2019
26
Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders. 61
31837067 2019
27
Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism. 61
31027853 2019
28
Mutation analysis of LRP10 in Japanese patients with familial Parkinson's disease, progressive supranuclear palsy, and frontotemporal dementia. 61
31582232 2019
29
Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. 61
31796108 2019
30
Binding of [18F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients. 61
31848674 2019
31
Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. 61
31861888 2019
32
Presynaptic Striatal Dopaminergic Function in Atypical Parkinsonism: A Metaanalysis of Imaging Studies. 61
30979821 2019
33
Heritability in frontotemporal tauopathies. 61
30723775 2019
34
Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD. 61
31999351 2019
35
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome. 61
31860007 2019
36
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. 61
31631020 2019
37
Potential usefulness of signal intensity of cerebral gyri on quantitative susceptibility mapping for discriminating corticobasal degeneration from progressive supranuclear palsy and Parkinson's disease. 61
31267152 2019
38
Cerebrovascular pathology presenting as corticobasal syndrome: An autopsy case series of "vascular CBS". 61
31621626 2019
39
[Progressive supranuclear palsy-Richardson syndrome with visual attention disturbance (Holmes and Horrax) and ataxie optique (Garcin): a case report]. 61
31656263 2019
40
C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. 61
31327044 2019
41
Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial. 61
31710340 2019
42
Transcranial sonography in atypical parkinsonism: How reliable is it in real clinical practice? A multicentre comprehensive study. 61
31621617 2019
43
Late-onset Niemann-Pick disease type C overlapping with frontotemporal dementia syndromes: a case report. 61
31506735 2019
44
[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series. 61
31661038 2019
45
Globular glial tauopathy caused by MAPT P301T mutation: clinical and neuropathological findings. 61
31190169 2019
46
CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics. 61
31167811 2019
47
Treatment of psychiatric disturbances in hypokinetic movement disorders. 61
31241368 2019
48
Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders. 61
31513029 2019
49
Profound degeneration of wake-promoting neurons in Alzheimer's disease. 61
31416793 2019
50
Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. 61
31250152 2019

Variations for Corticobasal Degeneration

ClinVar genetic disease variations for Corticobasal Degeneration:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TBK1 NM_013254.4(TBK1):c.2107G>T (p.Glu703Ter)SNV Likely pathogenic 619188 rs1565825132 12:64891788-64891788 12:64498008-64498008

Expression for Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for Corticobasal Degeneration

Pathways related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 SOS1 RPS6KB1 ROCK2 ROCK1 MTOR CFL1
2
Show member pathways
12.72 SOS1 RPS6KB1 ROCK2 ROCK1 MTOR
3 12.68 SOS1 RPS6KB1 ROCK2 ROCK1 MTOR
4
Show member pathways
12.42 SOS1 ROCK2 ROCK1 CFL1
5 12.41 UCHL1 TARDBP RPS27A MAPT LRRK2
6
Show member pathways
12.26 ROCK2 ROCK1 MAPT CFL1
7
Show member pathways
12.22 SOS1 ROCK2 ROCK1 MAPT
8
Show member pathways
12.22 SOS1 RPS6KB1 ROCK2 ROCK1 MTOR
9 12.2 RPS6KB1 ROCK2 ROCK1 MTOR
10 11.89 RPS6KB1 MTOR MAPT CFL1
11 11.87 SOS1 RPS6KB1 ROCK1 MTOR CFL1
12
Show member pathways
11.51 SOS1 RPS6KB1 MTOR
13 11.41 SOS1 RPS6KB1 ROCK2 ROCK1 MTOR HSPB2
14 11.34 SOS1 RPS6KB1 ROCK2 ROCK1 MTOR
15 11.28 SOS1 ROCK2 ROCK1 CFL1
16 11.25 ROCK2 ROCK1 CFL1
17 11.1 SOS1 RPS6KB1 MTOR
18 11.07 RPS6KB1 ROCK2 ROCK1 CFL1
19
Show member pathways
10.8 RPS6KB1 MTOR
20 10.75 RPS6KB1 MTOR

GO Terms for Corticobasal Degeneration

Cellular components related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.83 UCHL1 SOS1 RPS6KB1 RPS27A ROCK2 ROCK1
2 axon GO:0030424 9.72 UCHL1 MAPT LRRK2 KIF13B CRYAB
3 neuronal cell body GO:0043025 9.63 UCHL1 SOS1 PITX3 MTOR MAPT LRRK2
4 mitochondrial outer membrane GO:0005741 9.56 RPS6KB1 RPS27A MTOR LRRK2
5 cytoplasm GO:0005737 9.55 UCHL1 TARDBP SOS1 RPS6KB1 RPS27A ROCK2

Biological processes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.04 RPS6KB1 RPS27A PRDX5 CRYAB CFL1
2 negative regulation of gene expression GO:0010629 9.96 TARDBP ROCK2 MAPT CRYAB
3 negative regulation of protein phosphorylation GO:0001933 9.8 TARDBP MTOR LRRK2
4 protein phosphorylation GO:0006468 9.8 RPS6KB1 ROCK2 ROCK1 MTOR LRRK2 CFL1
5 regulation of cellular response to heat GO:1900034 9.79 MTOR MAPT CRYAB
6 regulation of actin cytoskeleton organization GO:0032956 9.79 ROCK2 ROCK1 MTOR
7 Rho protein signal transduction GO:0007266 9.78 ROCK2 ROCK1 CFL1
8 regulation of autophagy GO:0010506 9.77 ROCK1 MAPT LRRK2
9 regulation of macroautophagy GO:0016241 9.77 UCHL1 MTOR GBA
10 cellular response to starvation GO:0009267 9.74 MTOR LRRK2 GBA
11 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.73 RPS27A ROCK2 ROCK1
12 regulation of circadian rhythm GO:0042752 9.72 TARDBP ROCK2 MTOR
13 negative regulation of neuron death GO:1901215 9.69 LRRK2 GBA CSF3
14 regulation of stress fiber assembly GO:0051492 9.66 ROCK2 ROCK1
15 mRNA destabilization GO:0061157 9.66 ROCK2 ROCK1
16 positive regulation of connective tissue replacement GO:1905205 9.65 ROCK2 ROCK1
17 negative regulation of macroautophagy GO:0016242 9.65 MTOR LRRK2
18 regulation of synaptic vesicle endocytosis GO:1900242 9.64 ROCK1 LRRK2
19 response to transforming growth factor beta GO:0071559 9.63 ROCK2 ROCK1
20 regulation of protein metabolic process GO:0051246 9.63 ROCK2 GBA
21 mitotic cytokinesis GO:0000281 9.63 ROCK2 ROCK1 CFL1
22 negative regulation of biomineral tissue development GO:0070168 9.58 ROCK2 ROCK1
23 axonal transport of mitochondrion GO:0019896 9.58 UCHL1 MAPT
24 regulation of mitochondrial fission GO:0090140 9.54 MAPT LRRK2
25 intracellular distribution of mitochondria GO:0048312 9.52 MAPT LRRK2
26 regulation of establishment of endothelial barrier GO:1903140 9.49 ROCK2 ROCK1
27 regulation of cell junction assembly GO:1901888 9.48 ROCK2 ROCK1
28 response to angiotensin GO:1990776 9.43 ROCK2 ROCK1
29 negative regulation of bicellular tight junction assembly GO:1903347 9.4 ROCK2 ROCK1
30 negative regulation of myosin-light-chain-phosphatase activity GO:0035509 9.37 ROCK2 ROCK1
31 neuron projection arborization GO:0140058 9.26 ROCK1 LRRK2
32 peptidyl-threonine phosphorylation GO:0018107 9.26 ROCK2 ROCK1 MTOR LRRK2
33 regulation of angiotensin-activated signaling pathway GO:0110061 9.16 ROCK2 ROCK1
34 peptidyl-serine phosphorylation GO:0018105 9.02 RPS6KB1 ROCK2 ROCK1 MTOR LRRK2

Molecular functions related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.11 UCHL1 TARDBP SOS1 RPS6KB1 RPS27A ROCK2
2 protein kinase activity GO:0004672 9.77 RPS6KB1 ROCK2 ROCK1 MTOR LRRK2
3 protein serine/threonine kinase activity GO:0004674 9.65 RPS6KB1 ROCK2 ROCK1 MTOR LRRK2
4 microtubule binding GO:0008017 9.62 MAPT LRRK2 KIF13B CRYAB
5 Rho GTPase binding GO:0017048 9.13 ROCK2 ROCK1 LRRK2
6 Rho-dependent protein serine/threonine kinase activity GO:0072518 8.62 ROCK2 ROCK1

Sources for Corticobasal Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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