CBGD
MCID: CRT033
MIFTS: 53

Corticobasal Degeneration (CBGD)

Categories: Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Corticobasal Degeneration

MalaCards integrated aliases for Corticobasal Degeneration:

Name: Corticobasal Degeneration 54 55 30 74
Corticobasal Syndrome 54 60
Cortical-Basal Ganglionic Degeneration 54
Cortico-Basal Ganglionic Degeneration 54
Cbgd 54

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 G31.0
Orphanet 60 ORPHA454887
UMLS 74 C0393570

Summaries for Corticobasal Degeneration

NINDS : 55 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement),disequilibrium (impaired balance); and limb dystonia (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, myoclonus (muscular jerks), and dysphagia (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary : Corticobasal Degeneration, also known as corticobasal syndrome, is related to supranuclear palsy, progressive, 1 and pick disease of brain. An important gene associated with Corticobasal Degeneration is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Human cytomegalovirus infection and NFAT and Cardiac Hypertrophy. The drugs Iodine and cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and tongue, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

NIH Rare Diseases : 54 Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known. Treatment depends on the symptoms in each person. People with corticobasal degeneration usually do not survive beyond an average of 7 years after symptoms begin. Aspiration pneumonia or other complications are usually the cause of death.

Wikipedia : 77 Corticobasal degeneration (CBD or corticobasal ganglionic degeneration CBGD) is a rare,... more...

Related Diseases for Corticobasal Degeneration

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 supranuclear palsy, progressive, 1 32.7 LRRK2 MAPT RPS27A
2 pick disease of brain 32.7 CRYAB MAPT RPS27A TARDBP
3 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 32.7 MAPT RPS27A
4 semantic dementia 32.6 MAPT RPS27A TARDBP
5 frontotemporal dementia 32.1 CRYAB LRRK2 MAPT RPS27A TARDBP
6 leukoencephalopathy, hereditary diffuse, with spheroids 32.0 CRYAB MAPT RPS27A
7 dementia 30.9 GBA LRRK2 MAPT TARDBP
8 multiple system atrophy 1 30.7 LRRK2 MAPT RPS27A
9 movement disease 29.9 GBA LRRK2 MAPT
10 amyotrophic lateral sclerosis 1 29.8 CRYAB HSPB2 MAPT RPS27A TARDBP
11 progressive supranuclear palsy-corticobasal syndrome 12.3
12 apraxia 10.7
13 alzheimer disease 10.7
14 aphasia 10.6
15 myoclonus 10.5
16 creutzfeldt-jakob disease 10.3
17 dystonia 10.3
18 inclusion body myositis 10.2 MAPT RPS27A TARDBP
19 hereditary late-onset parkinson disease 10.1 GBA LRRK2
20 motor neuron disease 10.1
21 hemiparkinsonism-hemiatrophy syndrome 10.1
22 basal ganglia calcification 10.1
23 neuroleptic malignant syndrome 10.1
24 lateral sclerosis 10.1
25 rem sleep behavior disorder 10.1
26 progressive non-fluent aphasia 10.1
27 depression 10.1
28 nominal aphasia 10.1 MAPT TARDBP
29 patulous eustachian tube 10.1
30 dural sinus malformation 10.1
31 postencephalitic parkinson disease 10.1 LRRK2 MAPT TARDBP
32 cataract 16, multiple types 10.0 CRYAB HSPB2 PITX3
33 tremor 10.0 GBA LRRK2 MAPT
34 agraphia 10.0
35 carotid artery occlusion 10.0
36 charles bonnet syndrome 10.0
37 stiff-person syndrome 10.0
38 hydrocephalus, normal-pressure 10.0
39 apraxia of eyelid opening 10.0
40 hydrocephalus 10.0
41 pulmonary fibrosis 10.0
42 olivopontocerebellar atrophy 10.0
43 antiphospholipid syndrome 10.0
44 complex regional pain syndrome 10.0
45 striatonigral degeneration 10.0
46 alien hand syndrome 10.0
47 arachnoid cysts 10.0
48 early-onset, autosomal dominant alzheimer disease 10.0
49 neurosyphilis 10.0
50 spasticity 10.0

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to Corticobasal Degeneration

Symptoms & Phenotypes for Corticobasal Degeneration

GenomeRNAi Phenotypes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.02 MTOR RPS6KB1
2 Decreased viability with paclitaxel GR00179-A-2 9.02 MTOR
3 Decreased viability with paclitaxel GR00179-A-3 9.02 MTOR RPS6KB1

MGI Mouse Phenotypes related to Corticobasal Degeneration:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 CFL1 CRYAB GBA HSPB2 LRRK2 MAPT
2 cellular MP:0005384 10.29 CFL1 CRYAB GBA HSPB2 LRRK2 MAPT
3 cardiovascular system MP:0005385 10.27 CFL1 GBA HSPB2 LRRK2 MAPT MTOR
4 growth/size/body region MP:0005378 10.2 CFL1 GBA MAPT MTOR PITX3 ROCK1
5 homeostasis/metabolism MP:0005376 10.18 CFL1 GBA KIF13B LRRK2 MAPT MTOR
6 hematopoietic system MP:0005397 10.17 CSF3 GBA LRRK2 MAPT MTOR PITX3
7 immune system MP:0005387 10.11 CSF3 GBA LRRK2 MAPT MTOR PITX3
8 integument MP:0010771 9.97 CFL1 CSF3 GBA LRRK2 MAPT PITX3
9 nervous system MP:0003631 9.93 CFL1 GBA LRRK2 MAPT MOBP MTOR
10 muscle MP:0005369 9.86 CRYAB MAPT MTOR ROCK1 ROCK2 RPS6KB1
11 no phenotypic analysis MP:0003012 9.56 CFL1 KIF13B LRRK2 MAPT MTOR PITX3
12 renal/urinary system MP:0005367 9.17 CFL1 CSF3 LRRK2 MAPT MTOR ROCK1

Drugs & Therapeutics for Corticobasal Degeneration

Drugs for Corticobasal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4 7553-56-2 807
2 cadexomer iodine Phase 4
3 Calamus Phase 4
4 Pharmaceutical Solutions Phase 4
5
Pimavanserin Approved, Investigational Phase 3 706779-91-1 16058810
6
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 2, Phase 3 303-98-0 5281915
7 Micronutrients Phase 2, Phase 3
8 Nutrients Phase 2, Phase 3
9 Trace Elements Phase 2, Phase 3
10 Vitamins Phase 2, Phase 3
11 Ubiquinone Phase 2, Phase 3
12 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
13 Psychotropic Drugs Phase 3,Phase 1,Phase 2
14 Tranquilizing Agents Phase 3,Phase 1,Phase 2
15 Serotonin Agents Phase 3
16 Serotonin Antagonists Phase 3
17 Neurotransmitter Agents Phase 3
18 Antiparkinson Agents Phase 3
19 Antipsychotic Agents Phase 3
20 Serotonin 5-HT2 Receptor Antagonists Phase 3
21
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
22
Lithium carbonate Approved Phase 1, Phase 2 554-13-2
23 Antidepressive Agents Phase 1, Phase 2
24 Antimanic Agents Phase 1, Phase 2
25 Fluorodeoxyglucose F18 Phase 2
26 Radiopharmaceuticals Phase 2,Not Applicable
27 Antibodies Phase 1
28 Immunoglobulins Phase 1
29 Antibodies, Monoclonal Phase 1
30 taxane Phase 1
31
Pramipexole Approved, Investigational 104632-26-0 119570 59868
32
Carbidopa Approved 28860-95-9 34359
33
Ropinirole Approved, Investigational 91374-21-9, 91374-20-8 5095 497540
34
Amantadine Approved 768-94-5 2130
35
Entacapone Approved, Investigational 130929-57-6 5281081
36
Levodopa Approved 59-92-7 6047
37 leucine
38 Flutemetamol Not Applicable
39 Immunologic Factors Not Applicable
40 Vaccines Not Applicable

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
2 Effects of Coenzyme Q10 in PSP and CBD Completed NCT00532571 Phase 2, Phase 3 CoQ10
3 Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis Recruiting NCT03325556 Phase 3 Placebo;Pimavanserin 34 mg;Pimavanserin 20 mg
4 A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration Completed NCT00703677 Phase 1, Phase 2 Lithium
5 Electrical Polarization of the Brain in Corticobasal Syndrome Completed NCT00273897 Phase 2
6 Davunetide (AL-108) in Predicted Tauopathies - Pilot Study Completed NCT01056965 Phase 2 davunetide (AL-108, NAP);Placebo nasal spray
7 The Differential Diagnosis of Parkinson's Disease and Parkinsonism by Positron-emission Tomography Completed NCT01824056 Phase 2 18F-FDG
8 Novel Neuroimage Study in Tauopathies With Parkinsonism Active, not recruiting NCT03386669 Phase 2 F-18
9 Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers Completed NCT02167594 Phase 1 18F-AV-1451;florbetapir F18
10 BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES Recruiting NCT03658135 Phase 1 BIIB092
11 Safety Study of TPI-287 to Treat CBS and PSP Active, not recruiting NCT02133846 Phase 1 TPI 287 2 mg/m2;TPI-287 20 mg/m2;Placebo;TPI-287 6.3 mg/m2
12 Parkinson's Disease, Diagnostic Observations (PADDO) Unknown status NCT01249768
13 Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and Personalized Unknown status NCT01403519
14 Repetitive Transcranial Magnetic Stimulation (TMS) for Progressive Supranuclear Palsy and Corticobasal Degeneration Completed NCT01174771
15 Study of Tongue Pressures Completed NCT00013832
16 SudoScan as a Biomarker of Parkinson's Disease Completed NCT02767037 Not Applicable
17 PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK Recruiting NCT02778607
18 Human CNS Tau Kinetics in Tauopathies Recruiting NCT03545126
19 4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2 Recruiting NCT02966145
20 More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease Recruiting NCT03076671 Not Applicable
21 Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) Recruiting NCT02365922
22 Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders Recruiting NCT03299062 Not Applicable
23 Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography. Recruiting NCT02132052
24 ADDIA Proof-of-Performance Clinical Study Recruiting NCT03030586
25 Gait Analysis in Neurological Disease Recruiting NCT02994719 Anti-Parkinson medication
26 Positron Emission Tomography (PET) Imaging of Tau Pathology in Neurodegenerative Disease Recruiting NCT03143374
27 Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Recruiting NCT03225144
28 The Swedish BioFINDER 2 Study Recruiting NCT03174938 Not Applicable
29 Diagnosing Frontotemporal Lobar Degeneration Recruiting NCT02964637
30 In-Home Care for Patients With PSP and Related Disorders Recruiting NCT03552484 Not Applicable
31 Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks Recruiting NCT03153371
32 Genetic Characterization of Movement Disorders and Dementias Recruiting NCT02014246
33 Comprehensive Assessment of Neurodegeneration and Dementia Recruiting NCT03402919
34 4 Repeat Tauopathy Neuroimaging Initiative Active, not recruiting NCT01804452
35 Study for the Early Diagnosis of Parkinson's Disease Active, not recruiting NCT02283073
36 The Sunnybrook Dementia Study: Mapping Brain Changes in Alzheimer's, Vascular and Other Dementias Active, not recruiting NCT01800214
37 Vaccination Uptake (VAX) in PD Active, not recruiting NCT02874274 Not Applicable
38 Brain Network Activation in Patients With Movement Disorders Not yet recruiting NCT03269201
39 Autologous Stem/Stromal Cells in Neurological Disorders and Disease Not yet recruiting NCT03297177 Not Applicable

Search NIH Clinical Center for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

Genetic tests related to Corticobasal Degeneration:

# Genetic test Affiliating Genes
1 Corticobasal Degeneration 30

Anatomical Context for Corticobasal Degeneration

MalaCards organs/tissues related to Corticobasal Degeneration:

42
Cortex, Brain, Tongue, Testes, Eye, Spinal Cord, Temporal Lobe

Publications for Corticobasal Degeneration

Articles related to Corticobasal Degeneration:

(show top 50) (show all 542)
# Title Authors Year
1
Improved mobility, cognition and disease severity in Corticobasal Degeneration of an African-American male after 12 weeks of Adapted tango: a case study. ( 30801264 )
2019
2
Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration. ( 30850568 )
2019
3
Persistence of limb dystonia and myoclonus during sleep in corticobasal syndrome: a case series. ( 30853191 )
2019
4
Clinical, neuropsychological and imaging characteristics of Alzheimer's disease patients presenting as corticobasal syndrome. ( 30711771 )
2019
5
Accumulation of Tau Protein, Metabolism and Perfusion-Application and Efficacy of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Imaging in the Examination of Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS). ( 30837933 )
2019
6
FDG-PET patterns associated with underlying pathology in corticobasal syndrome. ( 30700592 )
2019
7
Corticobasal Syndrome: Neuroimaging and Neurophysiological Advances. ( 30720235 )
2019
8
Mixed Alzheimer's and Lewy-related Pathology Can Cause Corticobasal Syndrome with Visual Hallucinations. ( 30799336 )
2019
9
Authors' Reply: Mixed Alzheimer's and Lewy-related Pathology can Cause Corticobasal Syndrome with Visual Hallucinations. ( 30799371 )
2019
10
Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration. ( 29799310 )
2018
11
Clinical Routine FDG-PET Imaging of Suspected Progressive Supranuclear Palsy and Corticobasal Degeneration: A Gatekeeper for Subsequent Tau-PET Imaging? ( 29973914 )
2018
12
Corticobasal degeneration: key emerging issues. ( 29063240 )
2018
13
Corticobasal degeneration with TDP-43 pathology presenting with progressive supranuclear palsy syndrome: a distinct clinicopathologic subtype. ( 29926172 )
2018
14
Cognitive reserve maps the core loci of neurodegeneration in Corticobasal Degeneration. ( 29931723 )
2018
15
Corticobasal Syndrome Associated with Antiphospholipid Syndrome Secondary to Systemic Lupus Erythematosus. ( 29854505 )
2018
16
Lower limb apraxia in corticobasal syndrome. ( 30103952 )
2018
17
Bilateral upper limb rehabilitation with videogame-based feedback in corticobasal degeneration: a case reports study. ( 30015554 )
2018
18
Pathophysiology of corticobasal degeneration: Insights from neurophysiological studies. ( 30327223 )
2018
19
Is it Useful to Classify Progressive Supranuclear Palsy and Corticobasal Degeneration as Different Disorders? No. ( 30363409 )
2018
20
Myoclonus-Dominant Corticobasal Degeneration. ( 30637289 )
2018
21
Long-Term Non-Invasive Treatment via Intranasal Administration of Nerve Growth Factor Protects the Human Brain in Frontotemporal Dementia associated with Corticobasal Syndrome: A Pilot Study. ( 30480250 )
2018
22
Assessment of Patient Self-awareness and Related Neural Correlates in Frontotemporal Dementia and Corticobasal Syndrome. ( 29088311 )
2018
23
Early stage memory impairment, visual hallucinations, and myoclonus combined with temporal lobe atrophy predict Alzheimer's disease pathology in corticobasal syndrome. ( 29987978 )
2018
24
Blink reflex recovery cycle to differentiate progressive supranuclear palsy from corticobasal syndrome. ( 29754397 )
2018
25
Corticobasal syndrome in a man with Gaucher disease type 1: Expansion of the understanding of the neurological spectrum. ( 30364808 )
2018
26
Diffuse Lewy body disease manifesting as corticobasal syndrome: A rare form of Lewy body disease. ( 29898972 )
2018
27
PBB3 binding in a patient with corticobasal syndrome. ( 29932465 )
2018
28
Disease-related patterns of in vivo pathology in Corticobasal syndrome. ( 30090966 )
2018
29
24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome. ( 30245667 )
2018
30
Dual-Phase 18F-FP-CIT PET in Corticobasal Syndrome. ( 30371594 )
2018
31
Diffuse Lewy body disease manifesting as corticobasal syndrome: A rare form of Lewy body disease. ( 30455262 )
2018
32
Reduced capacity for empathy in corticobasal syndrome and its impact on carer burden. ( 30520157 )
2018
33
Reversible Corticobasal Syndrome due to Coeliac Disease. ( 30637273 )
2018
34
Globular Glial Tauopathy May be Mistaken for Corticobasal Syndrome-Pointers for the Clinician. ( 30838299 )
2018
35
Subacute corticobasal syndrome following internal carotid endarterectomy. ( 29153271 )
2018
36
Diagnosing Corticobasal Syndrome Based on the Presence of Visual Hallucinations and Imaging with Amyloid Positron Emission Tomography. ( 29269636 )
2018
37
Neurophysiology and neurochemistry of corticobasal syndrome. ( 29307007 )
2018
38
[18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation. ( 29497818 )
2018
39
Disentangling the neural correlates of corticobasal syndrome and corticobasal degeneration with systematic and quantitative ALE meta-analyses. ( 28649612 )
2017
40
Apathy in corticobasal degeneration: possible parietal involvement. ( 29306357 )
2017
41
Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease. ( 28235814 )
2017
42
An autopsied case of corticobasal degeneration presenting with frontotemporal dementia followed by myoclonus. ( 28707717 )
2017
43
Cognitive dysfunction in corticobasal degeneration. ( 28813088 )
2017
44
The Neuropsychology (Broadly Conceived) of Multiple System Atrophy, Progressive Supranuclear Palsy, and Corticobasal Degeneration. ( 28961692 )
2017
45
Levodopa-responsive depression associated with corticobasal degeneration: a case report. ( 28458551 )
2017
46
Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. ( 28271184 )
2017
47
A case of superior sagittal sinus intracranial dural arteriovenous fistula mimicking corticobasal syndrome. ( 28431635 )
2017
48
IgLON5 autoimmunity tested negative in patients with progressive supranuclear palsy and corticobasal syndrome. ( 28285943 )
2017
49
Functional disconnection of thalamic and cerebellar dentate nucleus networks in progressive supranuclear palsy and corticobasal syndrome. ( 28318985 )
2017
50
Prevalence and clinical characteristics of corticobasal syndrome with an initial symptom outside of the upper limb. ( 28190115 )
2017

Variations for Corticobasal Degeneration

Expression for Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for Corticobasal Degeneration

Pathways related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 CFL1 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
2
Show member pathways
12.69 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
3 12.67 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
4 12.43 LRRK2 MAPT RPS27A TARDBP UCHL1
5
Show member pathways
12.38 CFL1 MAPT ROCK1 ROCK2
6 12.37 CFL1 MAPT ROCK1 ROCK2
7
Show member pathways
12.25 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
8
Show member pathways
12.22 MAPT ROCK1 ROCK2 SOS1
9 11.92 CFL1 MAPT MTOR RPS6KB1
10 11.87 CFL1 MTOR ROCK1 RPS6KB1 SOS1
11 11.81 MTOR RPS6KB1 SOS1
12
Show member pathways
11.53 MTOR RPS6KB1 SOS1
13 11.4 HSPB2 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
14 11.34 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
15 11.28 CFL1 ROCK1 ROCK2 SOS1
16 11.27 CFL1 ROCK1 ROCK2
17 11.15 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
18 11.14 MTOR RPS6KB1 SOS1
19 11.07 CFL1 ROCK1 ROCK2 RPS6KB1
20 10.74 MTOR RPS6KB1

GO Terms for Corticobasal Degeneration

Cellular components related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.91 CRYAB LRRK2 MAPT MOBP MTOR PRDX5
2 cytosol GO:0005829 9.83 CFL1 CRYAB HSPB2 KIF13B LRRK2 MAPT
3 axon GO:0030424 9.65 CRYAB KIF13B LRRK2 MAPT UCHL1
4 neuronal cell body GO:0043025 9.63 LRRK2 MAPT MTOR PITX3 SOS1 UCHL1
5 mitochondrial outer membrane GO:0005741 9.62 LRRK2 MTOR RPS27A RPS6KB1
6 cytoplasm GO:0005737 9.55 CFL1 CRYAB HSPB2 KIF13B LRRK2 MAPT

Biological processes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.93 CFL1 LRRK2 MTOR ROCK1 ROCK2 RPS6KB1
2 Rho protein signal transduction GO:0007266 9.79 CFL1 ROCK1 ROCK2
3 negative regulation of protein phosphorylation GO:0001933 9.79 LRRK2 MTOR TARDBP
4 regulation of autophagy GO:0010506 9.77 LRRK2 MAPT ROCK1
5 cellular response to starvation GO:0009267 9.74 GBA LRRK2 MTOR
6 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.73 ROCK1 ROCK2 RPS27A
7 peptidyl-threonine phosphorylation GO:0018107 9.72 LRRK2 MTOR ROCK2
8 regulation of actin cytoskeleton organization GO:0032956 9.71 MTOR ROCK1 ROCK2
9 regulation of macroautophagy GO:0016241 9.7 GBA MTOR UCHL1
10 regulation of establishment of cell polarity GO:2000114 9.67 ROCK1 ROCK2
11 smooth muscle contraction GO:0006939 9.66 ROCK1 ROCK2
12 regulation of dendritic spine morphogenesis GO:0061001 9.66 CFL1 LRRK2
13 regulation of keratinocyte differentiation GO:0045616 9.65 ROCK1 ROCK2
14 regulation of stress fiber assembly GO:0051492 9.65 ROCK1 ROCK2
15 TOR signaling GO:0031929 9.65 MTOR RPS6KB1
16 negative regulation of neuron death GO:1901215 9.65 CSF3 GBA LRRK2
17 negative regulation of macroautophagy GO:0016242 9.64 LRRK2 MTOR
18 positive regulation of connective tissue replacement GO:1905205 9.63 ROCK1 ROCK2
19 regulation of protein metabolic process GO:0051246 9.63 GBA ROCK2
20 response to transforming growth factor beta GO:0071559 9.62 ROCK1 ROCK2
21 axonal transport of mitochondrion GO:0019896 9.61 MAPT UCHL1
22 intracellular distribution of mitochondria GO:0048312 9.6 LRRK2 MAPT
23 negative regulation of protein homooligomerization GO:0032463 9.58 CRYAB GBA
24 regulation of mitochondrial fission GO:0090140 9.58 LRRK2 MAPT
25 negative regulation of biomineral tissue development GO:0070168 9.51 ROCK1 ROCK2
26 regulation of cellular response to heat GO:1900034 9.5 CRYAB MAPT MTOR
27 regulation of establishment of endothelial barrier GO:1903140 9.49 ROCK1 ROCK2
28 peptidyl-serine phosphorylation GO:0018105 9.46 LRRK2 MTOR ROCK2 RPS6KB1
29 negative regulation of bicellular tight junction assembly GO:1903347 9.43 ROCK1 ROCK2
30 negative regulation of myosin-light-chain-phosphatase activity GO:0035509 9.4 ROCK1 ROCK2
31 response to angiotensin GO:1990776 9.37 ROCK1 ROCK2
32 neuron projection arborization GO:0140058 9.26 LRRK2 ROCK1
33 response to amino acid GO:0043200 9.13 CFL1 MTOR RPS6KB1
34 regulation of angiotensin-activated signaling pathway GO:0110061 8.62 ROCK1 ROCK2
35 negative regulation of apoptotic process GO:0043066 10.04 CFL1 CRYAB PRDX5 RPS27A RPS6KB1

Molecular functions related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.72 LRRK2 MTOR ROCK1 ROCK2 RPS6KB1
2 protein binding GO:0005515 9.58 CFL1 CRYAB GBA HSPB2 KIF13B LRRK2
3 microtubule binding GO:0008017 9.56 CRYAB KIF13B LRRK2 MAPT
4 protein serine/threonine kinase activity GO:0004674 9.55 LRRK2 MTOR ROCK1 ROCK2 RPS6KB1
5 Rho GTPase binding GO:0017048 9.13 LRRK2 ROCK1 ROCK2

Sources for Corticobasal Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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