MCID: CRT033
MIFTS: 33

Corticobasal Degeneration

Categories: Muscle diseases, Neuronal diseases
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Aliases & Classifications for Corticobasal Degeneration

MalaCards integrated aliases for Corticobasal Degeneration:

Name: Corticobasal Degeneration 52 75 28 71

Classifications:



External Ids:

UMLS 71 C0393570

Summaries for Corticobasal Degeneration

NINDS: 52 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement),disequilibrium (impaired balance); and limb dystonia (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, myoclonus (muscular jerks), and dysphagia (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary: Corticobasal Degeneration is related to supranuclear palsy, progressive, 1 and frontotemporal dementia. An important gene associated with Corticobasal Degeneration is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Neuroscience. The drugs Lithium carbonate and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia: 75 Corticobasal degeneration (CBD) is a rare neurodegenerative disease involving the cerebral cortex and... more...

Related Diseases for Corticobasal Degeneration

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 supranuclear palsy, progressive, 1 31.7 TARDBP MAPT
2 frontotemporal dementia 31.7 TARDBP MAPT
3 pick disease of brain 31.5 TARDBP MAPT
4 parkinsonism 31.0 TARDBP MAPT
5 aphasia 31.0 TARDBP MAPT
6 ideomotor apraxia 30.8 TARDBP MAPT
7 dementia 30.7 TARDBP MAPT
8 movement disease 30.5 TARDBP MAPT
9 dementia, lewy body 30.4 TARDBP MAPT
10 creutzfeldt-jakob disease 30.2 TARDBP MAPT
11 agraphia 30.2 TARDBP MAPT
12 akinetic mutism 30.0 TARDBP MAPT
13 pseudobulbar palsy 29.8 TARDBP MAPT
14 speech disorder 29.8 TARDBP MAPT
15 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 29.8 TARDBP MAPT
16 speech and communication disorders 29.7 TARDBP MAPT
17 motor neuron disease 29.7 TARDBP MAPT
18 nominal aphasia 29.6 TARDBP MAPT
19 postencephalitic parkinson disease 29.6 TARDBP MAPT
20 kuru 29.6 TARDBP MAPT
21 autosomal dominant cerebellar ataxia 29.4 TARDBP MAPT
22 huntington disease 29.1 TARDBP MAPT
23 leukoencephalopathy, hereditary diffuse, with spheroids 1 11.1
24 papillon-lefevre syndrome 11.0
25 apraxia 11.0
26 myoclonus 10.8
27 dystonia 10.8
28 corticobasal syndrome 10.8
29 alzheimer disease, familial, 1 10.7
30 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.6
31 conjugate gaze palsy 10.6
32 tremor 10.6
33 multiple system atrophy 1 10.6
34 progressive non-fluent aphasia 10.4
35 cerebral atrophy 10.4
36 grn-related frontotemporal lobar degeneration 10.4
37 parkinson disease, late-onset 10.4
38 amyotrophic lateral sclerosis 1 10.4
39 argyria 10.4
40 spasticity 10.3
41 kearns-sayre syndrome 10.3
42 lateral sclerosis 10.3
43 agnosia 10.3
44 mutism 10.3
45 parkinson-dementia syndrome 10.3
46 focal dystonia 10.3
47 rare neurodegenerative disease 10.3
48 hydrocephalus 10.2
49 rem sleep behavior disorder 10.2
50 classic progressive supranuclear palsy syndrome 10.2

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to Corticobasal Degeneration

Symptoms & Phenotypes for Corticobasal Degeneration

GenomeRNAi Phenotypes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.4 MAPT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.4 MAPT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.4 TARDBP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.4 MAPT
5 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.4 MAPT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.4 MAPT

Drugs & Therapeutics for Corticobasal Degeneration

Drugs for Corticobasal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 1, Phase 2 554-13-2
2 Antidepressive Agents Phase 1, Phase 2
3 Psychotropic Drugs Phase 1, Phase 2
4 Tubulin Modulators Phase 1
5 Taxane Phase 1 108169
6 Antibodies, Monoclonal Phase 1
7 Antibodies Phase 1
8 Immunoglobulins Phase 1
9
Apomorphine Approved, Investigational 41372-20-7, 58-00-4 6005
10
Dopamine Approved 62-31-7, 51-61-6 681
11
Ropinirole Approved, Investigational 91374-21-9 5095
12
Pramipexole Approved, Investigational 104632-26-0, 104632-25-9, 104632-28-2 4885 119570 59868
13
Carbidopa Approved 28860-95-9 34359 38101
14
Levodopa Approved 59-92-7, 63-84-3 6047
15
Tolcapone Approved, Withdrawn 134308-13-7 4659569
16
Entacapone Approved, Investigational 130929-57-6 5281081
17
Amantadine Approved 768-94-5 2130
18 Flutemetamol Investigational 637003-10-2
19
1,2-Dihydroxybenzene Experimental 120-80-9 289
20
Tilavonemab Investigational 2096513-89-0
21 Gastrointestinal Agents
22 Emetics
23 Dihydroxyphenylalanine
24 Anesthetics
25 Radiopharmaceuticals
26 Dopamine agonists
27 Dopamine Agents
28 Neurotransmitter Agents
29 Adjuvants, Immunologic
30 Carbidopa, levodopa drug combination
31 Antiviral Agents
32 Protective Agents
33 Aromatic Amino Acid Decarboxylase Inhibitors
34 Anti-Infective Agents
35 Analgesics, Non-Narcotic
36 Antiparkinson Agents
37 Antioxidants
38 Analgesics
39 Immunologic Factors
40 Nootropic Agents
41 Pharmaceutical Solutions
42
D-Leucine Experimental, Investigational, Nutraceutical 328-38-1, 61-90-5 439524 6106

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration Completed NCT00703677 Phase 1, Phase 2 Lithium
2 18F-AV-1451 Injection for Brain Imaging of Tau in Subjects With Progressive Supranuclear Palsy (PSP), Subjects With Corticobasal Degeneration (CBD) and Healthy Volunteers Completed NCT02167594 Phase 1 Flortaucipir F18
3 A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Sequential Cohort, Dose-Ranging Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of TPI 287 in Patients With Primary Four Repeat Tauopathies: Corticobasal Syndrome or Progressive Supranuclear Palsy Completed NCT02133846 Phase 1 TPI 287 2 mg/m2;TPI-287 20 mg/m2;Placebo;TPI-287 6.3 mg/m2
4 A 12 Week Randomized, Double Blind, Placebo-Controlled Pilot Study of Davunetide (NAP, AL-108) in Predicted Tauopathies Completed NCT01056965 Phase 1 davunetide (AL-108, NAP);Placebo nasal spray
5 A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients With Four Different Primary Tauopathy Syndromes Terminated NCT03658135 Phase 1 BIIB092
6 Observational Longitudinal Study of Magnetic Resonance Imaging, Specimen Biomarkers, and Clinical Progression in Progressive Supranuclear Palsy and Corticobasal Degeneration Unknown status NCT01804452
7 A Multi-centre Proof-of-performance Clinical Study to Validate Blood-based Biomarker Candidates for the Diagnosis of Alzheimer's Disease Unknown status NCT03030586
8 Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks Unknown status NCT03153371
9 Noninvasive Cortical Stimulation (rTMS) for Motor and Non-Motor Features of Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD) Completed NCT01174771
10 Complex Eye Movements in Parkinson's Disease and Related Movement Disorders Completed NCT04925622
11 Subcutaneous Apomorphine in the Treatment of Progressive Supranuclear Palsy and Cortico Basal Degeneration (APOPARKA) Completed NCT04786158 Apomorphine
12 Human CNS Tau Kinetics in Tauopathies Completed NCT03545126
13 More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease Completed NCT03076671
14 Optimization of Morphomer-based Alpha-synuclein PET Tracers Completed NCT05067192
15 Defining Cognitive and Motor Phenotypes of Parkinson's Disease (PD) With Magnetoencephalography Completed NCT02132052
16 Rare Diseases Clinical Research Network Advancing Research and Treatment for Frontotemporal Lobar Degeneration [ARTFL]: Research Projects 1 & 2 Completed NCT02365922
17 Modifiable Variables in Parkinsonism (MVP) [Formerly CAM Care in PD] Recruiting NCT02194816
18 ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Recruiting NCT04363684
19 The Four-Repeat Tauopathy Neuroimaging Initiative Recruiting NCT02966145
20 PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK Recruiting NCT02778607
21 Assessing Skin Biomarkers for Preclinical Diagnosis of PD and Non-PD Parkinsonism Recruiting NCT04518059
22 The Swedish BioFINDER 2 Study Recruiting NCT03174938
23 Building Online Community to Improve Patient and Caregiver Outcomes in Parkinson Disease, Lewy Body Dementia and Related Disorders Recruiting NCT05222386
24 Gait Pattern Analysis in Neurological Disease Active, not recruiting NCT02994719 Anti-Parkinson medication
25 Mapping Functional Networks of Brain Activity (Brain Network Activation, BNA) Based on Analysis of Evoked Response Potential (ERP) EEG Signals in Patients With Movement Disorders Enrolling by invitation NCT03269201
26 Use Of Autologous Stem Cell Use In Neurological Non-neoplastic Disorders And Disease Not yet recruiting NCT03297177
27 Expanded Access to ABBV-8E12 No longer available NCT03744546 ABBV-8E12
28 tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study Withdrawn NCT04883229

Search NIH Clinical Center for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

Genetic tests related to Corticobasal Degeneration:

# Genetic test Affiliating Genes
1 Corticobasal Degeneration 28

Anatomical Context for Corticobasal Degeneration

Organs/tissues related to Corticobasal Degeneration:

MalaCards : Cortex, Brain, Eye, Skin, Temporal Lobe, Spinal Cord, Subthalamic Nucleus

Publications for Corticobasal Degeneration

Articles related to Corticobasal Degeneration:

(show top 50) (show all 1656)
# Title Authors PMID Year
1
Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies. 62
36269086 2022
2
Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration. 62
35976433 2022
3
Macroscopic diagnostic clue for parkinsonism. 62
35996308 2022
4
The many faces of globular glial tauopathy: a clinical and imaging study. 62
36256511 2022
5
Complementary value of metabolic and tau PET imaging in the diagnosis of corticobasal degeneration. 62
35723696 2022
6
Susceptibility-weighted imaging in corticobasal degeneration: Novel insights from a new case. 62
36170889 2022
7
18F-THK5351 PET for visualizing predominant lesions of pathologically confirmed corticobasal degeneration presenting with frontal behavioral-spatial syndrome. 62
35416513 2022
8
Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia. 62
35914945 2022
9
Can we really 'read' art to see the changing brain? A review and empirical assessment of clinical case reports and published artworks for systematic evidence of quality and style changes linked to damage or neurodegenerative disease. 62
36179555 2022
10
[Atypical Parkinson's syndrome in old age]. 62
35748931 2022
11
Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration. 62
35274674 2022
12
Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies. 62
35485527 2022
13
Brainstem atrophy is linked to extrapyramidal symptoms in frontotemporal dementia. 62
35377014 2022
14
The Significance of Asymmetry in the Assessment of Brain Perfusion in Atypical Tauopathic Parkinsonian Syndromes. 62
35885575 2022
15
Pilot Study for Correlation of Heart Rate Variability and Dopamine Transporter Brain Imaging in Patients with Parkinsonian Syndrome. 62
35808551 2022
16
Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases. 62
35447272 2022
17
The tauopathies: Neuroimaging characteristics and emerging experimental therapies. 62
35470528 2022
18
Molecular Simulations Reveal Distinct Energetic and Kinetic Binding Properties of [18F]PI-2620 on Tau Filaments from 3R/4R and 4R Tauopathies. 62
35762647 2022
19
Parkinsonism-Plus Syndrome Secondary to Neurosyphilis: Case Report and Literature Review. 62
36076672 2022
20
Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography. 62
35128565 2022
21
Relationship Between 18F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies. 62
34556525 2022
22
Differentially Expressed miRNAs in Age-Related Neurodegenerative Diseases: A Meta-Analysis. 62
35741796 2022
23
Neuropathology and emerging biomarkers in corticobasal syndrome. 62
35697501 2022
24
Four-repeat tauopathies and late-onset psychiatric disorders: Etiological relevance or incidental findings? 62
35774036 2022
25
Pallidal degenerations and related disorders: an update. 62
34363531 2022
26
18F-FDG PET Imaging in Neurodegenerative Dementing Disorders: Insights into Subtype Classification, Emerging Disease Categories, and Mixed Dementia with Copathologies. 62
35649653 2022
27
Imaging of Synaptic Density in Neurodegenerative Disorders. 62
35649655 2022
28
Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again. 62
35594661 2022
29
Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia. 62
35441216 2022
30
A Case of Pathologically Confirmed Corticobasal Degeneration Initially Presenting as Progressive Supranuclear Palsy Syndrome. 62
35668689 2022
31
Progressive supranuclear palsy and corticobasal degeneration: novel clinical concepts and advances in biomarkers. 62
35976324 2022
32
Genetic Architecture of Primary Tauopathies. 62
35609758 2022
33
Pathologically Verified Corticobasal Degeneration Mimicking Richardson's Syndrome Coexisting with Clinically and Radiologically Shunt-Responsive Normal Pressure Hydrocephalus. 62
35582317 2022
34
Clinical Aspects of the Differential Diagnosis of Parkinson's Disease and Parkinsonism. 62
35589315 2022
35
Delayed Detection of Hydrocephalus following Mildly Traumatic Subarachnoid Hemorrhage in Corticobasal Degeneration: A Case Report. 62
35815105 2022
36
Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Non-fluent/agrammatic Variant Primary Progressive Aphasia. 62
35623892 2022
37
PET-based classification of corticobasal syndrome. 62
35533530 2022
38
REM Sleep Behavior Disorder and Visual Hallucinations in a Pathologically Confirmed Case of Corticobasal Degeneration. 62
35402652 2022
39
Brain TDP-43 pathology in corticobasal degeneration: Topographical correlation with neuronal loss. 62
34913181 2022
40
Epidemiology of atypical parkinsonian syndromes. 62
35465274 2022
41
The Non-motor Symptoms, Disability Progression, and Survival Analysis of Atypical Parkinsonism: Case Series from Eastern India and Brief Review of Literature. 62
35694072 2022
42
Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration. 62
35486397 2022
43
Overview of tau PET molecular imaging. 62
35191407 2022
44
The clinical approach to the identification of higher-order visual dysfunction in neurodegenerative disease. 62
35320467 2022
45
[Autonomic Dysfunction in Tauopathies]. 62
35260524 2022
46
[Idiopathic Normal Pressure Hydrocephalus and Neurodegenerative Diseases: a Short Review of Differential Diagnosis]. 62
35400650 2022
47
Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization. 62
35246269 2022
48
Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration. 62
34672063 2022
49
Seed amplification and RT-QuIC assays to investigate protein seed structures and strains. 62
35258712 2022
50
Retina thickness in atypical parkinsonism: a systematic review and meta-analysis. 62
34245345 2022

Variations for Corticobasal Degeneration

Expression for Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for Corticobasal Degeneration

Pathways related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 TARDBP MAPT

GO Terms for Corticobasal Degeneration

Biological processes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.26 TARDBP MAPT
2 amyloid fibril formation GO:1990000 8.92 TARDBP MAPT

Molecular functions related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.92 TARDBP MAPT

Sources for Corticobasal Degeneration

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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