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MCID: CGH001
MIFTS: 35

Cough Variant Asthma

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cough Variant Asthma

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MalaCards integrated aliases for Cough Variant Asthma:

Name: Cough Variant Asthma 12 15 71

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12323
ICD9CM 34 493.82
ICD10 32 J45.991
UMLS 71 C0694548
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Summaries for Cough Variant Asthma

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Disease Ontology : 12 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary : Cough Variant Asthma is related to hypereosinophilic syndrome and allergic hypersensitivity disease. An important gene associated with Cough Variant Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Inflammatory Response Pathway and Trk receptor signaling mediated by PI3K and PLC-gamma. The drugs Procaterol and Terbutaline have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and trachea.

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Related Diseases for Cough Variant Asthma

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Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 30.5 RNASE3 IL5 IL4 IGHE
2 allergic hypersensitivity disease 30.3 RNASE3 IL5 IL4 IGHE
3 ige responsiveness, atopic 30.2 RNASE3 IL5 IL4 IGHE
4 allergic bronchopulmonary aspergillosis 30.1 IL5 IL4 IGHE
5 rhinitis 30.0 RNASE3 NGF IL5 IL4 IGHE
6 bronchitis 30.0 TAC1 RNASE3 IL5 IL4 IGHE
7 allergic rhinitis 30.0 RNASE3 NGF IL5 IL4 IGHE
8 dermatitis 29.8 RNASE3 IL5 IL4 IGHE
9 allergic asthma 29.8 RNASE3 IL5 IL4 IGHE
10 asthma 29.6 TRPV1 TAC1 RNASE3 NGF IL5 IL4
11 pulmonary disease, chronic obstructive 27.9 TRPV1 TAC1 RNASE3 IL5 IL4 ATP12A
12 loeffler endocarditis 10.5 RNASE3 IL5
13 disseminated eosinophilic collagen disease 10.4 RNASE3 IL5
14 blepharoconjunctivitis 10.4 RNASE3 IL4
15 pemphigoid gestationis 10.4 RNASE3 IL5
16 nickel allergic contact dermatitis 10.4 IL5 IL4
17 loiasis 10.4 IL5 IL4
18 trichinosis 10.4 IL5 IL4
19 mikulicz disease 10.4 IL5 IL4
20 anisakiasis 10.4 RNASE3 IGHE
21 wells syndrome 10.4 RNASE3 IL5
22 angiostrongyliasis 10.4 IL5 IL4
23 corticosteroid allergy 10.3 IL5 IL4
24 immunodeficiency with hyper-igm, type 1 10.3 IL4 IGHE
25 granulomatous angiitis 10.3 IL5 ACE
26 giant papillary conjunctivitis 10.3 RNASE3 IL4
27 hyper ige syndrome 10.3 IL4 IGHE
28 beta-lactam allergy 10.3 IL4 IGHE
29 strongyloidiasis 10.3 IL5 IGHE
30 scleritis 10.3 IL5 IL4
31 chronic eosinophilic pneumonia 10.3 RNASE3 IL5
32 filarial elephantiasis 10.3 IL5 IL4
33 gastroenteritis 10.3 RNASE3 IL5 IL4
34 intestinal schistosomiasis 10.2 IL5 IL4
35 sick building syndrome 10.2 TRPV1 IGHE
36 endomyocardial fibrosis 10.2 RNASE3 IL5 IL4
37 cardiac sarcoidosis 10.2 IL5 ACE
38 elephantiasis 10.2 RNASE3 IL5 IL4
39 cow milk allergy 10.2 RNASE3 IL5 IL4
40 eosinophilic pneumonia 10.2 RNASE3 IL5 IL4
41 conjunctival disease 10.2 RNASE3 IL5 IL4
42 pulmonary eosinophilia 10.2 RNASE3 IL5 IL4
43 common cold 10.2 RNASE3 IL5 IL4
44 parasitic helminthiasis infectious disease 10.2 RNASE3 IL5 IL4
45 toxocariasis 10.2 RNASE3 IL5 IGHE
46 paragonimiasis 10.2 RNASE3 IL5 IGHE
47 proteasome-associated autoinflammatory syndrome 1 10.2 RNASE3 IL5 IL4
48 bronchiolitis 10.2 RNASE3 IL5 IL4
49 echinococcosis 10.2 RNASE3 IL5 IGHE
50 vernal conjunctivitis 10.2 RNASE3 IL4 IGHE

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to Cough Variant Asthma
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Symptoms & Phenotypes for Cough Variant Asthma

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Drugs & Therapeutics for Cough Variant Asthma

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Drugs for Cough Variant Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
2
Terbutaline Approved Phase 4 23031-25-6 5403
3
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
4
Ephedrine Approved Phase 4 299-42-3 9294
5
Chlorpheniramine Approved Phase 4 132-22-9, 113-92-8 2725
6
Pseudoephedrine Approved Phase 4 90-82-4 7028
7
Budesonide Approved Phase 4 51333-22-3 63006 5281004
8
Bambuterol Investigational Phase 4 81732-65-2, 81732-46-9 54766
9 Sympathomimetics Phase 4
10 Tocolytic Agents Phase 4
11 Nasal Decongestants Phase 4
12 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
13 Vasoconstrictor Agents Phase 4
14 Antitussive Agents Phase 4
15 Expectorants Phase 4
16 Anti-Obesity Agents Phase 4
17 Appetite Depressants Phase 4
18 Leukotriene Antagonists Phase 4
19 Adrenergic Agonists Phase 4
20 Adrenergic beta-Agonists Phase 4
21 Neurotransmitter Agents Phase 4
22 Respiratory System Agents Phase 4
23 Anti-Asthmatic Agents Phase 4
24 glucocorticoids Phase 4
25 Autonomic Agents Phase 4
26 Bronchodilator Agents Phase 4
27 Adrenergic Agents Phase 4
28 Anti-Inflammatory Agents Phase 4
29 Formoterol Fumarate Phase 4
30 Hormone Antagonists Phase 4
31 Hormones Phase 4
32 Methacholine Chloride Phase 4
33 Muscarinic Agonists Phase 4
34 Cholinergic Agents Phase 4
35 Budesonide, Formoterol Fumarate Drug Combination Phase 4
36
Fenofibrate Approved 49562-28-9 3339
37
Nitric Oxide Approved 10102-43-9 145068
38
Montelukast Approved 158966-92-8 5281040
39
Capsaicin Approved 404-86-4 1548943
40
Prednisone Approved, Vet_approved 53-03-2 5865
41
Mannitol Approved, Investigational 69-65-8 453 6251
42 Protective Agents
43 Free Radical Scavengers
44 Vasodilator Agents
45 Antioxidants
46 Dermatologic Agents
47 Antipruritics
48 Natriuretic Agents
49 diuretics

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Multicentered, Double-blinded, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Procaterol Hydrochloride With Inhaled Glucocorticoid in Treatment Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
2 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
3 Randomised, Open-label, Parallel-group Study of the Response to Bronchodilator Treatment in Subjects With Eosinophilic Bronchitis and the Mechanism of Varied Responses to Bronchodilator Treatment. Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
4 Randomised, Double-blinded, Placebo-Controlled Study of Therapeutic Effect of Su-Huang Antitussive Capsule on Cough Variant Asthma(CVA) Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
5 Randomised, Open-label, Parallel-group Study of Therapeutic Effect of Leukotriene Modulator Montelukast Alone or Combined With Inhaled Corticosteroid on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
6 The Effects of Alvokast (Montelukast) in Patients With Chronic Cough Completed NCT01754220 Phase 4 Montelukast
7 Prospective Single-centre, Double Blind Randomised Trial of Montelukast in Patients With Chronic Cough and Bronchial Hyperreactivity Completed NCT00453765 Phase 4 montelukast;placebo
8 The Efficacy of Budesonide/Formoterol in Cough Variant Asthma -- A Multi-center Randomized, Controlled Clinical Trial Not yet recruiting NCT04171180 Phase 4 budesonide/formoterol
9 Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline in Individuals With Cough Variant Asthma and Chronic Cough Not yet recruiting NCT03105843 Phase 4 Methacholine (MCh) Challenge Testing
10 Longitudinal Study of Children With a Chronic Cough and the Impact of Gastroesophageal Reflux Withdrawn NCT00771706 Phase 3 Proton Pump Inhibitor;Placebo
11 Observation of the Respiratory Impedance and Inflammation in Cough Variant Asthma Patients Treated in Combination of Chanqin Granules. Unknown status NCT03319043 Phase 1, Phase 2 Chanqin granules
12 Difference in Gene Expression Profile in Peripheral Blood Mononuclear Cells and Inflammation Profile in Patients With Classic Asthma, Cough Variant Asthma, and Eosinophilic Bronchitis Compared With Healthy Controls Unknown status NCT02555345
13 Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data Unknown status NCT03169699
14 A Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Patient Aged 5-Year Old or Younger in Outpatient Department Completed NCT00660114
15 Bronchodilating and Bronchoprotective Effects of Deep Inspirations in Asthma, Cough Variant Asthma and Chronic Cough With Normal Airway Sensitivity and Sensory-Mechanical Responses to High-Dose Methacholine in Healthy Normal Subjects Completed NCT01659476
16 Evaluating the Efficacy of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma Recruiting NCT03573284
17 Influence of Type of Inhaler on Cough Severity and Tolerance of Therapy in Patients With Cough Variant or Cough Predominant Asthma Recruiting NCT04203472
18 The Usefulness of the Methacholine Challenge Test and Capsaicin Inhalation Cough Challenge in a Prediction of Response to Management in Adults With a Chronic Cough. Recruiting NCT03363698
19 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting NCT01064245 high-dose methacholine challenge test

Search NIH Clinical Center for Cough Variant Asthma

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Genetic Tests for Cough Variant Asthma

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Anatomical Context for Cough Variant Asthma

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MalaCards organs/tissues related to Cough Variant Asthma:

40
Testes, Lung, Trachea, Endothelial
Sources

Publications for Cough Variant Asthma

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Articles related to Cough Variant Asthma:

(show top 50) (show all 351)
# Title Authors PMID Year
1
Diagnostic value of FeNO and MMEF for predicting cough variant asthma in chronic cough patients with or without allergic rhinitis. 61
31820665 2019
2
A traditional Chinese patent medicine-Suhuang zhike capsule for cough variant asthma in adults: A protocol of systematic review and meta-analysis of randomized controlled trials. 61
31852128 2019
3
Value of Exhaled Nitric Oxide and FEF25-75 in Identifying Factors Associated With Chronic Cough in Allergic Rhinitis. 61
31552718 2019
4
Classification of asthma. 61
31690376 2019
5
Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity. 61
31552721 2019
6
Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigs. 61
31601467 2019
7
Reflux characteristics in patients with gastroesophageal reflux-related chronic cough complicated by laryngopharyngeal reflux. 61
31807511 2019
8
Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough. 61
31182314 2019
9
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. 61
31315072 2019
10
[The Mysterious Cough - a Case-Based Proposal of Differential Diagnosis]. 61
31480953 2019
11
ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. 61
31515408 2019
12
Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation. 61
31259654 2019
13
Characteristics of Chinese chronic cough patients. 61
31176802 2019
14
Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China. 61
31559054 2019
15
Etiologies associated with chronic cough and its clinical characteristics in school-age children. 61
31463138 2019
16
Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum. 61
31258680 2019
17
Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway. 61
31354164 2019
18
Fractional Exhaled Nitric Oxide (FeNO) Combined with Pulmonary Function Parameters Shows Increased Sensitivity and Specificity for the Diagnosis of Cough Variant Asthma in Children. 61
31120043 2019
19
[Causes of chronic cough in children in Chongqing, China: an analysis of 202 cases]. 61
31104658 2019
20
Chronic cough and obesity. 61
30817992 2019
21
Montelukast and Budesonide for Childhood Cough Variant Asthma. 61
30925958 2019
22
[Clinical effect of fluticasone propionate, montelukast sodium and ketotifen in treatment of cough variant asthma in children]. 61
31014435 2019
23
[The role of leukotriene in the pathogenesis of cough variant asthma]. 61
30845400 2019
24
Upper airway cough syndrome in 103 children. 61
30855345 2019
25
[Do not diagnose postinfectious cough as cough variant asthma]. 61
30845390 2019
26
Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs. 61
30415484 2019
27
Diagnostic value of fractional exhaled nitric oxide in cough-variant asthma: an updated meta-analysis. 61
30706744 2019
28
Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system. 61
30808365 2019
29
Chinese herbal medicine for the treatment of cough variant asthma: a study protocol for a double-blind randomized controlled trial. 61
30606237 2019
30
A retrospective study of clinical features of cough variant asthma in Chinese adults. 61
30675172 2019
31
Clinical and pulmonary function changes in cough variant asthma with small airway disease. 61
31303871 2019
32
Etiology analysis of nonspecific chronic cough in children of 5 years and younger. 61
30653096 2019
33
A breath sound analysis in children with cough variant asthma. 61
29857933 2019
34
Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough. 61
30746207 2018
35
Functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma. 61
30546407 2018
36
An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids. 61
30728339 2018
37
Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease? 61
28917529 2018
38
Pearls and pitfalls in the diagnosis of cough variant asthma. 61
30401324 2018
39
Sputum interleukin-25 correlates with asthma severity: a preliminary study. 61
30429702 2018
40
Pattern of Response to Bronchial Challenge with Histamine in Patients with Non-Atopic Cough-Variant and Classic Asthma. 61
30002276 2018
41
Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma. 61
28846444 2018
42
Montelukast and budesonide combination for children with chronic cough-variant asthma. 61
30045280 2018
43
Animal Derived Thiol Induced Work Exacerbated Asthma: A Brief Case Report of a Unique Workplace Hazard. 61
30623404 2018
44
[Thought and method of classic formulae in treatment of chronic cough]. 61
29950056 2018
45
WeChat Public Account Use Improves Clinical Control of Cough-Variant Asthma: A Randomized Controlled Trial. 61
29536984 2018
46
Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide. 61
27731932 2018
47
Role of prostaglandin E2 in bronchoconstriction-triggered cough response in guinea pigs. 61
28951192 2018
48
[PROBLEMS ASSOCIATED WITH THE DIAGNOSIS OF PROLONGED/CHRONIC COUGH IN CLINICAL SETTINGS]. 61
30146625 2018
49
[THE CAUSES OF ACUTE COUGH: A SINGLE-CENTER STUDY IN JAPAN]. 61
29459525 2018
50
[USEFULNESS OF THE FORCED OSCILLATION TECHNIQUE IN THE DIAGNOSIS OF COUGH VARIANT ASTHMA WITH PROLONGED OR CHRONIC COUGH]. 61
30022785 2018
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Variations for Cough Variant Asthma

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Expression for Cough Variant Asthma

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Search GEO for disease gene expression data for Cough Variant Asthma.
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Pathways for Cough Variant Asthma

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Pathways related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Inflammatory Response Pathway 1
10.89 IL5 IL4
2
Trk receptor signaling mediated by PI3K and PLC-gamma 1
10.83 TRPV1 NGF
3
Development and heterogeneity of the ILC family 1
10.76 IL5 IL4
4
Cytokines and Inflammatory Response 1
10.62 IL5 IL4
5
IL4-mediated signaling events 1
10.6 IL5 IL4 IGHE
6
OX40 Pathway 63
10.37 IL5 IL4
Sources

GO Terms for Cough Variant Asthma

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Cellular components related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TAC1 RNASE3 NGF IL5 IL4 ATP4A
2 extracellular region GO:0005576 9.23 TTLL1 TAC1 RNASE3 NGF IL5 IL4

Biological processes related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to pain GO:0048265 9.37 TRPV1 TAC1
2 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 negative regulation of heart rate GO:0010459 8.62 TRPV1 TAC1

Molecular functions related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 NGF IL5 IL4
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
Sources

Sources for Cough Variant Asthma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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