MCID: CGH001
MIFTS: 34

Cough Variant Asthma

Categories: Respiratory diseases

Aliases & Classifications for Cough Variant Asthma

MalaCards integrated aliases for Cough Variant Asthma:

Name: Cough Variant Asthma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12323
ICD9CM 34 493.82
SNOMED-CT 67 409663006
ICD10 32 J45.991
UMLS 71 C0694548

Summaries for Cough Variant Asthma

Disease Ontology : 12 A chronic asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary : Cough Variant Asthma is related to bronchitis and asthma. An important gene associated with Cough Variant Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Inflammatory Response Pathway and Trk receptor signaling mediated by PI3K and PLC-gamma. The drugs Procaterol and Montelukast have been mentioned in the context of this disorder. Affiliated tissues include trachea and endothelial.

Related Diseases for Cough Variant Asthma

Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 bronchitis 30.9 RNASE3 IL5 IL4
2 asthma 30.6 TRPV1 RNASE3 NGF IL5 IL4 IGHE
3 hypereosinophilic syndrome 30.5 RNASE3 IL5 IL4 IGHE
4 acute asthma 30.5 RNASE3 IL5 IL4
5 allergic disease 30.5 RNASE3 IL5 IL4
6 ige responsiveness, atopic 30.2 RNASE3 IL5 IL4 IGHE
7 rhinitis 30.2 RNASE3 NGF IL5 IL4 IGHE
8 allergic rhinitis 30.2 RNASE3 NGF IL5 IL4 IGHE
9 chronic asthma 30.1 RNASE3 IL5 IL4 IGHE
10 allergic bronchopulmonary aspergillosis 30.1 IL5 IL4 IGHE
11 pneumonia 30.1 IL5 IL4 ACE
12 dermatitis 29.9 RNASE3 IL5 IL4 IGHE
13 allergic asthma 29.9 RNASE3 IL5 IL4 IGHE
14 loeffler endocarditis 10.3 RNASE3 IL5
15 pemphigoid 10.3 IL5 IL4
16 childhood-onset asthma 10.3 RNASE3 IGHE
17 chromium allergic contact dermatitis 10.3 IL5 IL4
18 cow milk allergy 10.3 IL5 IL4
19 disseminated eosinophilic collagen disease 10.3 RNASE3 IL5
20 patulous eustachian tube 10.3 RNASE3 IL5
21 loiasis 10.3 IL5 IL4
22 pemphigoid gestationis 10.3 RNASE3 IL5
23 mikulicz disease 10.3 IL5 IL4
24 penicillin allergy 10.3 IL4 IGHE
25 prurigo nodularis 10.3 RNASE3 NGF
26 trichinosis 10.3 IL5 IL4
27 anisakiasis 10.3 RNASE3 IGHE
28 nickel allergic contact dermatitis 10.3 IL5 IL4
29 wells syndrome 10.3 RNASE3 IL5
30 mite infestation 10.3 IL5 IL4
31 giant papillary conjunctivitis 10.3 RNASE3 IL4
32 angiostrongyliasis 10.3 IL5 IL4
33 mucocutaneous leishmaniasis 10.2 IL5 IL4
34 taeniasis 10.2 IL5 IL4
35 filarial elephantiasis 10.2 IL5 IL4
36 granulomatous angiitis 10.2 IL5 ACE
37 legume allergy 10.2 IL5 IL4
38 chronic eosinophilic pneumonia 10.2 RNASE3 IL5
39 fruit allergy 10.2 IL5 IL4
40 beta-lactam allergy 10.2 IL4 IGHE
41 mononeuritis multiplex 10.2 IL5 ACE
42 idiopathic nephrotic syndrome 10.2 IL4 ACE
43 scleritis 10.2 IL5 IL4
44 intestinal schistosomiasis 10.2 IL5 IL4
45 status asthmaticus 10.2 RNASE3 IL5
46 esophagitis 10.2 RNASE3 IL5 IL4
47 gastroenteritis 10.2 RNASE3 IL5 IL4
48 cardiac sarcoidosis 10.2 IL5 ACE
49 timothy grass allergy 10.2 RNASE3 IL5 IL4
50 endomyocardial fibrosis 10.2 RNASE3 IL5 IL4

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to Cough Variant Asthma

Symptoms & Phenotypes for Cough Variant Asthma

Drugs & Therapeutics for Cough Variant Asthma

Drugs for Cough Variant Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
2
Montelukast Approved Phase 4 158966-92-8 5281040
3
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
4
Budesonide Approved Phase 4 51333-22-3 63006 5281004
5
Bambuterol Investigational Phase 4 81732-65-2, 81732-46-9 54766
6 Sympathomimetics Phase 4
7 Leukotriene Antagonists Phase 4
8 Budesonide, Formoterol Fumarate Drug Combination Phase 4
9 Antitussive Agents Phase 4
10 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
11 Anti-Asthmatic Agents Phase 4
12 Bronchodilator Agents Phase 4
13 Adrenergic beta-Agonists Phase 4
14 glucocorticoids Phase 4
15 Adrenergic Agents Phase 4
16 Adrenergic Agonists Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Hormone Antagonists Phase 4
19 Hormones Phase 4
20 Formoterol Fumarate Phase 4
21 Respiratory System Agents Phase 4
22 Neurotransmitter Agents Phase 4
23 Methacholine Chloride Phase 4
24 Muscarinic Agonists Phase 4
25 Cholinergic Agents Phase 4
26
Nitric Oxide Approved 10102-43-9 145068
27
Fenofibrate Approved 49562-28-9 3339
28 Protective Agents
29 Antioxidants
30 Vasodilator Agents
31 Endothelium-Dependent Relaxing Factors

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Randomised, Open-label, Parallel-group Study of the Response to Bronchodilator Treatment in Subjects With Eosinophilic Bronchitis and the Mechanism of Varied Responses to Bronchodilator Treatment. Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
2 A Multicentered, Double-blinded, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Procaterol Hydrochloride With Inhaled Glucocorticoid in Treatment Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
3 Randomised, Open-label, Parallel-group Study of Therapeutic Effect of Leukotriene Modulator Montelukast Alone or Combined With Inhaled Corticosteroid on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
4 Randomised, Double-blinded, Placebo-Controlled Study of Therapeutic Effect of Su-Huang Antitussive Capsule on Cough Variant Asthma(CVA) Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
5 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
6 The Efficacy of Budesonide/Formoterol in Cough Variant Asthma -- A Multi-center Randomized, Controlled Clinical Trial Recruiting NCT04171180 Phase 4 budesonide/formoterol
7 Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline in Individuals With Cough Variant Asthma and Chronic Cough Not yet recruiting NCT03105843 Phase 4 Methacholine (MCh) Challenge Testing
8 Observation of the Respiratory Impedance and Inflammation in Cough Variant Asthma Patients Treated in Combination of Chanqin Granules. Unknown status NCT03319043 Phase 1, Phase 2 Chanqin granules
9 Evaluating the Efficacy of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma Unknown status NCT03573284
10 Difference in Gene Expression Profile in Peripheral Blood Mononuclear Cells and Inflammation Profile in Patients With Classic Asthma, Cough Variant Asthma, and Eosinophilic Bronchitis Compared With Healthy Controls Unknown status NCT02555345
11 A Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Patient Aged 5-Year Old or Younger in Outpatient Department Completed NCT00660114
12 Bronchodilating and Bronchoprotective Effects of Deep Inspirations in Asthma, Cough Variant Asthma and Chronic Cough With Normal Airway Sensitivity and Sensory-Mechanical Responses to High-Dose Methacholine in Healthy Normal Subjects Completed NCT01659476

Search NIH Clinical Center for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

Anatomical Context for Cough Variant Asthma

MalaCards organs/tissues related to Cough Variant Asthma:

40
Trachea, Endothelial

Publications for Cough Variant Asthma

Articles related to Cough Variant Asthma:

(show top 50) (show all 395)
# Title Authors PMID Year
1
Therapeutic effects and mechanisms study of Hanchuan Zupa Granule in a Guinea pig model of cough variant asthma. 61
33358856 2021
2
Small airway dysfunction in patients with cough variant asthma: a retrospective cohort study. 61
33536015 2021
3
Simultaneous determination of nine constituents by validated UFLC-MS/MS in the plasma of cough variant asthma rats and its application to pharmacokinetic study after oral administration of Huanglong cough oral liquid. 61
33171336 2021
4
The Predicative Clinical Features Associated with Chronic Cough That Has a Single Underlying Cause. 61
32693212 2021
5
A 16-Year-Old Boy With Cough and Fever in the Era of COVID-19. 61
32788269 2021
6
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation. 61
33460751 2021
7
Effect of San'ao decoction with scorpio and bombyx batryticatus on CVA mice model via airway inflammation and regulation of TRPA1/TRPV1/TRPV5 channels. 61
32890712 2021
8
Cough reflex sensitivity and fractional exhaled nitric oxide in children with asthma. 61
33471545 2020
9
Montelukast sodium combined with budesonide for cough variant asthma in children. 61
33242945 2020
10
Helicobacter pylori is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. 61
32952638 2020
11
A multicenter, prospective, observational study on montelukast monotherapy or montelukast-based combinations treating cough variant asthma. 61
33282359 2020
12
Isolated night cough in children: how does it differ from wheeze? 61
33083445 2020
13
Methacholine-induced cough as an indicator of bronchodilator-responsive cough. 61
33039668 2020
14
[The secondary prevention effect and influence on serum sIgG4, IL-27 and IL-33 levels of subcutaneous immunotherapy in children with allergic rhinitis and cough variant asthma]. 61
33040502 2020
15
Perspectives on chronic cough in Korea. 61
33145096 2020
16
Drug-induced chronic cough and the possible mechanism of action. 61
32921095 2020
17
Relationship between pulmonary function changes and chronic cough in children with cough variant asthma. 61
33161697 2020
18
Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study. 61
32795993 2020
19
The causes of acute cough: a tertiary-care hospital study in Japan. 61
32736491 2020
20
Inhibitory effect of Xiaochuan pill on obstinate cough and its role in regulation of TLR4-MyD88-NF-κBp65 signaling pathway. 61
32879080 2020
21
Arnold Nerve Reflex: Vagal Hypersensitivity in Chronic Cough With Various Causes. 61
31945317 2020
22
Successful treatment of coronavirus disease 2019 in a patient with asthma. 61
32605700 2020
23
Close Associations of Gum Bleeding with Systemic Diseases in Late Adolescence. 61
32560147 2020
24
Cough in hypereosinophilic syndrome: case report and literature review. 61
32293378 2020
25
Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigs. 61
31601467 2020
26
Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study. 61
32092472 2020
27
[The cough variant asthma]. 61
32598800 2020
28
Diagnostic value of FeNO and MMEF for predicting cough variant asthma in chronic cough patients: methodological issues. 61
32155100 2020
29
Characteristics of Chronic Cough in adults in Pakistani population: A cross sectional study. 61
32292434 2020
30
Diagnostic value of fractional exhaled nitric oxide in cough-variant asthma: an updated meta-analysis. 61
30706744 2020
31
Identification of quality control markers in Suhuang antitussive capsule based on HPLC-PDA fingerprint and anti-inflammatory screening. 61
31901736 2020
32
Current Status and Future Directions of Chronic Cough in China. 61
31912413 2020
33
Mepolizumab: an alternative therapy for idiopathic chronic eosinophilic pneumonia with glucocorticoid intolerance. 61
32884574 2020
34
Clinical Characteristics of Chronic Cough in Korea. 61
31905430 2020
35
ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. 61
31515408 2020
36
Diagnostic value of volumetric capnography in patients with chronic cough variant asthma. 61
33084765 2020
37
lncRNA PCGEM1 strengthens anti-inflammatory and lung protective effects of montelukast sodium in children with cough-variant asthma. 61
32520202 2020
38
Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of HuangQiXiXin Decoction on Cough Variant Asthma and Evidence-Based Medicine Approach Validation. 61
33178315 2020
39
Suhuang Zhike Capsules for the Treatment of Cough Variant Asthma: A Meta-analysis. 61
33488757 2020
40
Methacholine-Induced Cough in the Absence of Asthma: Insights From Impulse Oscillometry. 61
33123021 2020
41
Small Airways Dysfunction and Bronchial Hyper-Responsiveness in Cough Variant Asthma. 61
33324088 2020
42
Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma. 61
33376381 2020
43
The clinical usefulness of a new hand-held device for fractional exhaled nitric oxide measurement, NIOX VERO®, for diagnosing the etiology of cough. 61
33148899 2020
44
A traditional Chinese patent medicine-Suhuang zhike capsule for cough variant asthma in adults: A protocol of systematic review and meta-analysis of randomized controlled trials. 61
31852128 2019
45
Heterogeneity of perception of symptoms in patients with asthma. 61
32030239 2019
46
Diagnostic value of FeNO and MMEF for predicting cough variant asthma in chronic cough patients with or without allergic rhinitis. 61
31820665 2019
47
Classification of asthma. 61
31690376 2019
48
Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity. 61
31552721 2019
49
Value of Exhaled Nitric Oxide and FEF25-75 in Identifying Factors Associated With Chronic Cough in Allergic Rhinitis. 61
31552718 2019
50
Reflux characteristics in patients with gastroesophageal reflux-related chronic cough complicated by laryngopharyngeal reflux. 61
31807511 2019

Variations for Cough Variant Asthma

Expression for Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for Cough Variant Asthma

GO Terms for Cough Variant Asthma

Cellular components related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 RNASE3 NGF IL5 IL4 ATP4A ACE
2 extracellular region GO:0005576 9.17 TTLL1 RNASE3 NGF IL5 IL4 IGHE

Biological processes related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microglial cell activation GO:0001774 9.37 TRPV1 IL4
2 innate immune response in mucosa GO:0002227 9.32 RNASE3 IL4
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 NGF IL5 IL4
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Cough Variant Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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