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MCID: CGH001
MIFTS: 35

Cough Variant Asthma

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cough Variant Asthma

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MalaCards integrated aliases for Cough Variant Asthma:

Name: Cough Variant Asthma 12 15 74

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12323
ICD9CM 36 493.82
ICD10 34 J45.991
UMLS 74 C0694548
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Summaries for Cough Variant Asthma

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Disease Ontology : 12 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary : Cough Variant Asthma is related to asthma and bronchitis. An important gene associated with Cough Variant Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Allograft rejection and Immune response IFN alpha/beta signaling pathway. The drugs Procaterol and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and endothelial.

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Related Diseases for Cough Variant Asthma

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Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 asthma 30.8 IL4 IL5 NGF RNASE3
2 bronchitis 30.2 IL5 RNASE3
3 allergic bronchopulmonary aspergillosis 30.0 IL4 IL5
4 aspergillosis 30.0 IL4 IL5
5 hypereosinophilic syndrome 29.7 IL4 IL5 RNASE3
6 rhinitis 29.2 IL4 IL5 NGF RNASE3
7 allergic rhinitis 29.2 IL4 IL5 NGF RNASE3
8 loeffler endocarditis 10.2 IL5 RNASE3
9 paragonimiasis 10.2 IL5 RNASE3
10 cow milk allergy 10.2 IL5 RNASE3
11 eosinophilic gastroenteritis 10.2 IL5 RNASE3
12 status asthmaticus 10.2 IL5 RNASE3
13 blepharoconjunctivitis 10.2 IL4 RNASE3
14 chronic eosinophilic pneumonia 10.2 IL5 RNASE3
15 eosinophilic pneumonia 10.2 IL5 RNASE3
16 giant papillary conjunctivitis 10.2 IL4 RNASE3
17 sinusitis 10.2 IL5 RNASE3
18 pollen allergy 10.2 IL5 RNASE3
19 otitis media 10.2 IL4 RNASE3
20 nickel allergic contact dermatitis 10.2 IL4 IL5
21 allergic contact dermatitis 10.2 IL4 IL5
22 contact dermatitis 10.1 IL4 IL5
23 wells syndrome 10.1 IL5 RNASE3
24 scleritis 10.1 IL4 IL5
25 egg allergy 10.1 IL4 IL5
26 sulfamethoxazole allergy 10.1 IL4 IL5
27 angiostrongyliasis 10.1 IL4 IL5
28 trichinosis 10.1 IL4 IL5
29 churg-strauss syndrome 10.1 IL5 RNASE3
30 apple allergy 10.1 IL4 IL5
31 gaucher disease, type ii 10.1 IL4 IL5
32 non-suppurative otitis media 10.1 IL4 IL5
33 cellulitis 10.1 IL5 RNASE3
34 eosinophilic meningitis 10.1 IL4 IL5
35 prurigo nodularis 10.1 NGF RNASE3
36 intestinal schistosomiasis 10.1 IL4 IL5
37 chronic tic disorder 10.1 IL4 IL5
38 filarial elephantiasis 10.1 IL4 IL5
39 eosinophilic gastritis 10.1 IL4 IL5
40 conjunctival nevus 10.1 NGF RNASE3
41 toxic oil syndrome 10.1 IL4 IL5
42 vernal conjunctivitis 10.1 IL4 RNASE3
43 folliculitis 10.1 IL4 IL5
44 enterobiasis 10.1 IL4 IL5
45 common cold 10.1 IL5 RNASE3
46 paranasal sinus disease 10.1 IL4 IL5
47 paracoccidioidomycosis 10.0 IL4 IL5
48 yellow fever 10.0 IL4 IL5
49 cutaneous leishmaniasis 10.0 IL4 IL5
50 leishmaniasis 10.0 IL4 IL5

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to Cough Variant Asthma
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Symptoms & Phenotypes for Cough Variant Asthma

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Drugs & Therapeutics for Cough Variant Asthma

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Drugs for Cough Variant Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
2
Budesonide Approved Phase 4,Phase 1,Phase 2 51333-22-3 5281004 63006
3
Pseudoephedrine Approved Phase 4,Not Applicable 90-82-4 7028
4
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Not Applicable 93-14-1 3516
5
Ephedrine Approved Phase 4,Not Applicable 299-42-3 9294
6
Montelukast Approved Phase 4 158966-92-8 5281040
7
Terbutaline Approved Phase 4 23031-25-6 5403
8
Bambuterol Investigational Phase 4 81732-65-2, 81732-46-9 54766
9 Adrenergic beta-Agonists Phase 4,Phase 1,Phase 2,Not Applicable
10 Respiratory System Agents Phase 4,Phase 1,Phase 2,Not Applicable
11 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
12 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2,Not Applicable
13 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 1,Phase 2,Not Applicable
14 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Not Applicable
15 Sympathomimetics Phase 4,Not Applicable
16 Adrenergic Agents Phase 4,Phase 1,Phase 2,Not Applicable
17 glucocorticoids Phase 4,Phase 1,Phase 2
18 Anti-Asthmatic Agents Phase 4,Phase 1,Phase 2,Not Applicable
19 Adrenergic Agonists Phase 4,Phase 1,Phase 2,Not Applicable
20 Bronchodilator Agents Phase 4,Phase 1,Phase 2,Not Applicable
21 Adrenergic alpha-Agonists Phase 4,Not Applicable
22 Expectorants Phase 4,Not Applicable
23 Nasal Decongestants Phase 4,Not Applicable
24 Vasoconstrictor Agents Phase 4,Not Applicable
25 Anti-Obesity Agents Phase 4,Not Applicable
26 Antitussive Agents Phase 4
27
Chlorpheniramine Phase 4,Not Applicable 113-92-8, 132-22-9 2725
28 Appetite Depressants Phase 4,Not Applicable
29 Chlorpheniramine, phenylpropanolamine drug combination Phase 4,Not Applicable
30 Hormone Antagonists Phase 4,Phase 1,Phase 2
31 Leukotriene Antagonists Phase 4
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1,Phase 2
33 Budesonide, Formoterol Fumarate Drug Combination Phase 4
34 Hormones Phase 4,Phase 1,Phase 2
35 Formoterol Fumarate Phase 4,Phase 1,Phase 2
36 Tocolytic Agents Phase 4,Not Applicable
37 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2,Not Applicable
38 Muscarinic Agonists Phase 4,Not Applicable
39 Cholinergic Agents Phase 4,Not Applicable
40 Methacholine Chloride Phase 4,Not Applicable
41
Fenofibrate Approved 49562-28-9 3339
42
Erythromycin Approved, Investigational, Vet_approved Not Applicable 114-07-8 441411 12560
43
Azithromycin Approved Not Applicable 83905-01-5 447043 55185
44
Ribavirin Approved Not Applicable 36791-04-5 37542
45
Ibuprofen Approved Not Applicable 15687-27-1 3672
46
Nitric Oxide Approved Not Applicable 10102-43-9 145068
47
Prednisone Approved, Vet_approved 53-03-2 5865
48
Capsaicin Approved 404-86-4 1548943
49
Mannitol Approved, Investigational Not Applicable 69-65-8 6251 453
50 Gastrointestinal Agents Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
2 Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
3 Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
4 The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
5 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
6 Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline Not yet recruiting NCT03105843 Phase 4 Methacholine (MCh) Challenge Testing
7 Observation of Cough Variant Asthma Treated in Combination of Chanqin Granules. Not yet recruiting NCT03319043 Phase 1, Phase 2 Chanqin granules
8 Gene Expression Profile and Inflammation Profile of Classic Asthma, Cough Variant Asthma and Eosinophilic Bronchitis Unknown status NCT02555345
9 Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data Unknown status NCT03169699
10 Effectiveness Study of Integrative Treatment for Pediatric Community Acquired Pneumonia Unknown status NCT02362906 Not Applicable Xiyanping injection;wind-heat formula granules;phlegm-heat formula granules;Fu-xiong San;second generation cephalosporin;Erythromycin;Azithromycin
11 Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Children Outpatients Completed NCT00660114
12 Bronchodilating and Bronchoprotective Effects of Deep Inspirations Completed NCT01659476 Not Applicable
13 Effectiveness Study of Integrative Treatment for Pediatric Pneumonia Completed NCT02069665 Not Applicable Xiyanping injection;Ribavirin Injection;Xiaoer Qingfei Heji (mixture);Zhi Ke San;Hua Tan San;Guaifenesin Syrup;Ibuprofen Suspension;salbutamol
14 Validity of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma Recruiting NCT03573284 Not Applicable
15 MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough Recruiting NCT03363698
16 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting NCT01064245 Not Applicable high-dose methacholine challenge test

Search NIH Clinical Center for Cough Variant Asthma

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Genetic Tests for Cough Variant Asthma

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Anatomical Context for Cough Variant Asthma

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MalaCards organs/tissues related to Cough Variant Asthma:

42
Testes, Lung, Endothelial, Skin
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Publications for Cough Variant Asthma

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Articles related to Cough Variant Asthma:

(show top 50) (show all 111)
# Title Authors Year
1
Montelukast and Budesonide for Childhood Cough Variant Asthma. ( 30925958 )
2019
2
Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system. ( 30808365 )
2019
3
A retrospective study of clinical features of cough variant asthma in Chinese adults. ( 30675172 )
2019
4
Diagnostic value of fractional exhaled nitric oxide in cough-variant asthma: an updated meta-analysis. ( 30706744 )
2019
5
A breath sound analysis in children with cough variant asthma. ( 29857933 )
2019
6
Chinese herbal medicine for the treatment of cough variant asthma: a study protocol for a double-blind randomized controlled trial. ( 30606237 )
2019
7
An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids. ( 30728339 )
2018
8
Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough. ( 30746207 )
2018
9
A lung sound analysis in a child thought to have cough variant asthma: A case report. ( 28673440 )
2018
10
Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma. ( 28846444 )
2018
11
Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease? ( 28917529 )
2018
12
WeChat Public Account Use Improves Clinical Control of Cough-Variant Asthma: A Randomized Controlled Trial. ( 29536984 )
2018
13
Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide. ( 27731932 )
2018
14
Therapeutic Effects of Kangzhi Syrup in a Guinea Pig Model of Ovalbumin-Induced Cough Variant Asthma. ( 29951106 )
2018
15
Montelukast and budesonide combination for children with chronic cough-variant asthma. ( 30045280 )
2018
16
Pearls and pitfalls in the diagnosis of cough variant asthma. ( 30401324 )
2018
17
Functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma. ( 30546407 )
2018
18
Correlation study of cough variant asthma and mycoplasma pneumonia infection in children. ( 28671088 )
2017
19
Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis. ( 28088474 )
2017
20
"Cold air" and/or "talking" as cough triggers, a sign for the diagnosis of cough variant asthma. ( 27886852 )
2016
21
Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials. ( 27522988 )
2016
22
Correlational study on atmospheric concentrations of fine particulate matter and children cough variant asthma. ( 27383318 )
2016
23
Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma. ( 27055910 )
2016
24
Budesonide suspension nebulization treatment in Chinese pediatric patients with cough variant asthma: a multi-center observational study. ( 26517446 )
2016
25
Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma. ( 26169899 )
2015
26
Letter to the Editor on Saito et al., "Cough variant asthma patients are more depressed and anxious than classic asthma patients.". ( 25959711 )
2015
27
Cough variant asthma patients are more depressed and anxious than classic asthma patients. ( 25837530 )
2015
28
Cough-variant asthma: a diagnostic dilemma in the occupational setting. ( 25530078 )
2015
29
Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma. ( 25329681 )
2015
30
Prevalence and clinical relevance of allergic rhinitis in patients with classic asthma and cough variant asthma. ( 24401902 )
2014
31
[Diagnosis and treatment of cough variant asthma]. ( 24834548 )
2014
32
A case of cough variant asthma undiagnosed for 16 years. ( 25988016 )
2014
33
Prof. Akio Niimi: the clinical identification of cough variant asthma. ( 25383214 )
2014
34
Matrix metalloproteinase 9 is involved in airway inflammation in cough variant asthma. ( 25187823 )
2014
35
A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma. ( 24348708 )
2013
36
Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. ( 24188204 )
2013
37
Clinical study on treatment of cough variant asthma by Chinese medicine. ( 23818206 )
2013
38
The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma. ( 23612495 )
2013
39
[Levels of nerve growth factor and interleukin-4 in the induced sputum of children with cough variant asthma]. ( 23234779 )
2012
40
Inflammatory mediators in induced sputum and airway hyperresponsiveness in cough variant asthma during long-term inhaled corticosteroid treatment. ( 22927709 )
2012
41
Heightened cough response to bronchoconstriction in cough variant asthma. ( 22672909 )
2012
42
Superiority of nebulized corticosteroids over dry powder inhalers in certain patients with cough variant asthma or cough-predominant asthma. ( 22627846 )
2012
43
Cough variant asthma: lessons learned from deep inspirations. ( 22139550 )
2012
44
Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. ( 22094623 )
2012
45
Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma. ( 21447965 )
2011
46
Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. ( 20172262 )
2010
47
Cough variant asthma and atopic cough. ( 22958894 )
2010
48
Comparable effect of a leukotriene receptor antagonist and long-acting betaâ‚‚-adrenergic agonist in cough variant asthma. ( 20929598 )
2010
49
Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. ( 20671058 )
2010
50
TCM differential treatment of cough variant asthma. ( 20397466 )
2010
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Variations for Cough Variant Asthma

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Expression for Cough Variant Asthma

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Search GEO for disease gene expression data for Cough Variant Asthma.
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Pathways for Cough Variant Asthma

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Pathways related to Cough Variant Asthma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 38 1
Show member pathways
 12.46 IL4 IL5 RNASE3
2
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 11.71 IL4 IL5 NGF
3
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.59 IL4 IL5 NGF
4
Hematopoietic cell lineage 38
11.52 IL4 IL5
5
Glucocorticoid receptor regulatory network 1
11.42 IL4 IL5
6
Innate Lymphoid Cell Differentiation Pathways 66
11.4 IL4 IL5
7
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.36 IL4 IL5
8
IL4-mediated signaling events 1
11.26 IL4 IL5
9
Lung fibrosis 1
11.23 IL4 IL5
10
Th2 Differentiation Pathway 66
11.03 IL4 IL5
11
Inflammatory Response Pathway 1
10.78 IL4 IL5
12
Development and heterogeneity of the ILC family 1
10.66 IL4 IL5
13
G-protein signaling_Rap2B regulation pathway 23
10.6 IL4 IL5 NGF
14
Cytokines and Inflammatory Response 1
10.42 IL4 IL5
15
OX40 Pathway 65
10.04 IL4 IL5
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GO Terms for Cough Variant Asthma

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Biological processes related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.13 IL4 IL5 NGF
2 positive regulation of B cell proliferation GO:0030890 8.62 IL4 IL5

Molecular functions related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 IL4 IL5 NGF
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Sources for Cough Variant Asthma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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