MCID: CGH001
MIFTS: 37

Cough Variant Asthma

Categories: Respiratory diseases

Aliases & Classifications for Cough Variant Asthma

MalaCards integrated aliases for Cough Variant Asthma:

Name: Cough Variant Asthma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12323
ICD9CM 34 493.82
SNOMED-CT 67 409663006
ICD10 32 J45.991
UMLS 71 C0694548

Summaries for Cough Variant Asthma

Disease Ontology : 12 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary : Cough Variant Asthma is related to cytokine deficiency and allergic bronchopulmonary aspergillosis. An important gene associated with Cough Variant Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Allograft rejection and Immune response Fc epsilon RI pathway. The drugs Procaterol and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and trachea.

Related Diseases for Cough Variant Asthma

Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 30.3 IL5 IL13
2 allergic bronchopulmonary aspergillosis 30.2 IL5 IL4 IGHE
3 hypereosinophilic syndrome 30.0 RNASE3 IL5 IL4 IL13 IGHE
4 ige responsiveness, atopic 29.7 RNASE3 IL5 IL4 IL13 IGHE
5 gastroesophageal reflux 29.7 IL5 IL4 ATP4A ATP12A
6 dermatitis 29.6 IL5 IL4 IL13 IGHE
7 pneumonia 29.6 IL5 IL4 IL13 ACE
8 rhinitis 29.5 RNASE3 NGF IL5 IL4 IL13 IGHE
9 allergic asthma 29.3 RNASE3 IL5 IL4 IL13 IGHE
10 bronchitis 29.2 TAC1 RNASE3 IL5 IL4 IL13 IGHE
11 asthma 28.9 TRPV1 TAC1 RNASE3 NGF IL5 IL4
12 allergic hypersensitivity disease 28.9 TAC1 RNASE3 IL5 IL4 IL13 IGHE
13 allergic rhinitis 28.6 TAC1 RNASE3 NGF IL5 IL4 IL13
14 pulmonary disease, chronic obstructive 26.8 TRPV1 TAC1 RNASE3 IL5 IL4 IL13
15 loeffler endocarditis 10.5 RNASE3 IL5
16 disseminated eosinophilic collagen disease 10.4 RNASE3 IL5
17 pemphigoid gestationis 10.4 RNASE3 IL5
18 anisakiasis 10.4 RNASE3 IGHE
19 nickel allergic contact dermatitis 10.4 IL5 IL4
20 granulomatous angiitis 10.4 IL5 ACE
21 wells syndrome 10.3 RNASE3 IL5
22 giant papillary conjunctivitis 10.3 RNASE3 IL4
23 gastroenteritis 10.3 RNASE3 IL5 IL4
24 mononeuritis of lower limb 10.3 TRPV1 NGF
25 aztreonam allergy 10.3 IL5 IL13
26 viral laryngitis 10.3 RNASE3 ATP12A
27 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
28 lesion of sciatic nerve 10.3 TRPV1 NGF
29 endomyocardial fibrosis 10.3 RNASE3 IL5 IL4
30 respiratory syncytial virus infectious disease 10.3 IL5 IL13
31 cefaclor allergy 10.3 IL5 IL13
32 cow milk allergy 10.3 RNASE3 IL5 IL4
33 sick building syndrome 10.3 TRPV1 IGHE
34 ceftriaxone allergy 10.3 IL5 IL13
35 loeffler syndrome 10.3 IL5 IL13
36 cellulitis 10.2 RNASE3 IL5 IL4
37 vernal conjunctivitis 10.2 RNASE3 IL4 IGHE
38 echinococcosis 10.2 RNASE3 IL5 IGHE
39 toxic oil syndrome 10.2 IL5 IL4 IGHE
40 ocular cicatricial pemphigoid 10.2 RNASE3 NGF IL4
41 chronic eosinophilic pneumonia 10.2 RNASE3 IL5
42 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IL5 IL13
43 contact dermatitis 10.2 NGF IL5 IL4
44 cardiac sarcoidosis 10.2 IL5 ACE
45 aphthous stomatitis 10.2 IL5 IL4 ACE
46 idiopathic nephrotic syndrome 10.2 IL4 IGHE ACE
47 vagus nerve disease 10.2 ATP4A ATP12A
48 chronic meningitis 10.2 IL5 IL13
49 omenn syndrome 10.2 IL5 IL4 IGHE
50 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to Cough Variant Asthma

Symptoms & Phenotypes for Cough Variant Asthma

Drugs & Therapeutics for Cough Variant Asthma

Drugs for Cough Variant Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
2
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
3
Montelukast Approved Phase 4 158966-92-8 5281040
4
Budesonide Approved Phase 4 51333-22-3 63006 5281004
5
Bambuterol Investigational Phase 4 81732-65-2, 81732-46-9 54766
6 Sympathomimetics Phase 4
7 Antitussive Agents Phase 4
8 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
9 Budesonide, Formoterol Fumarate Drug Combination Phase 4
10 Leukotriene Antagonists Phase 4
11 Adrenergic beta-Agonists Phase 4
12 Anti-Asthmatic Agents Phase 4
13 Adrenergic Agents Phase 4
14 glucocorticoids Phase 4
15 Bronchodilator Agents Phase 4
16 Adrenergic Agonists Phase 4
17 Hormones Phase 4
18 Hormone Antagonists Phase 4
19 Formoterol Fumarate Phase 4
20 Anti-Inflammatory Agents Phase 4
21 Neurotransmitter Agents Phase 4
22 Respiratory System Agents Phase 4
23 Methacholine Chloride Phase 4
24 Cholinergic Agents Phase 4
25 Muscarinic Agonists Phase 4
26
Fenofibrate Approved 49562-28-9 3339
27
Nitric Oxide Approved 10102-43-9 145068
28
Prednisone Approved, Vet_approved 53-03-2 5865
29
Capsaicin Approved 404-86-4 1548943
30
Mannitol Approved, Investigational 69-65-8 6251 453
31 Antioxidants
32 Vasodilator Agents
33 Protective Agents
34 Endothelium-Dependent Relaxing Factors
35 diuretics

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Multicentered, Double-blinded, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Procaterol Hydrochloride With Inhaled Glucocorticoid in Treatment Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
2 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
3 Randomised, Open-label, Parallel-group Study of the Response to Bronchodilator Treatment in Subjects With Eosinophilic Bronchitis and the Mechanism of Varied Responses to Bronchodilator Treatment. Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
4 Randomised, Double-blinded, Placebo-Controlled Study of Therapeutic Effect of Su-Huang Antitussive Capsule on Cough Variant Asthma(CVA) Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
5 Randomised, Open-label, Parallel-group Study of Therapeutic Effect of Leukotriene Modulator Montelukast Alone or Combined With Inhaled Corticosteroid on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
6 The Effects of Alvokast (Montelukast) in Patients With Chronic Cough Completed NCT01754220 Phase 4 Montelukast
7 Prospective Single-centre, Double Blind Randomised Trial of Montelukast in Patients With Chronic Cough and Bronchial Hyperreactivity Completed NCT00453765 Phase 4 montelukast;placebo
8 The Efficacy of Budesonide/Formoterol in Cough Variant Asthma -- A Multi-center Randomized, Controlled Clinical Trial Recruiting NCT04171180 Phase 4 budesonide/formoterol
9 Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline in Individuals With Cough Variant Asthma and Chronic Cough Not yet recruiting NCT03105843 Phase 4 Methacholine (MCh) Challenge Testing
10 Longitudinal Study of Children With a Chronic Cough and the Impact of Gastroesophageal Reflux Withdrawn NCT00771706 Phase 3 Proton Pump Inhibitor;Placebo
11 Observation of the Respiratory Impedance and Inflammation in Cough Variant Asthma Patients Treated in Combination of Chanqin Granules. Unknown status NCT03319043 Phase 1, Phase 2 Chanqin granules
12 Difference in Gene Expression Profile in Peripheral Blood Mononuclear Cells and Inflammation Profile in Patients With Classic Asthma, Cough Variant Asthma, and Eosinophilic Bronchitis Compared With Healthy Controls Unknown status NCT02555345
13 Evaluating the Efficacy of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma Unknown status NCT03573284
14 Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data Unknown status NCT03169699
15 A Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Patient Aged 5-Year Old or Younger in Outpatient Department Completed NCT00660114
16 Bronchodilating and Bronchoprotective Effects of Deep Inspirations in Asthma, Cough Variant Asthma and Chronic Cough With Normal Airway Sensitivity and Sensory-Mechanical Responses to High-Dose Methacholine in Healthy Normal Subjects Completed NCT01659476
17 Influence of Type of Inhaler on Cough Severity and Tolerance of Therapy in Patients With Cough Variant or Cough Predominant Asthma Recruiting NCT04203472
18 The Usefulness of the Methacholine Challenge Test and Capsaicin Inhalation Cough Challenge in a Prediction of Response to Management in Adults With a Chronic Cough. Recruiting NCT03363698
19 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting NCT01064245 high-dose methacholine challenge test

Search NIH Clinical Center for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

Anatomical Context for Cough Variant Asthma

MalaCards organs/tissues related to Cough Variant Asthma:

40
Testes, Lung, Trachea, Endothelial, Neutrophil

Publications for Cough Variant Asthma

Articles related to Cough Variant Asthma:

(show top 50) (show all 365)
# Title Authors PMID Year
1
Close Associations of Gum Bleeding with Systemic Diseases in Late Adolescence. 61
32560147 2020
2
Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study. 61
32092472 2020
3
Cough in hypereosinophilic syndrome: case report and literature review. 61
32293378 2020
4
Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigs. 61
31601467 2020
5
Diagnostic value of FeNO and MMEF for predicting cough variant asthma in chronic cough patients: methodological issues. 61
32155100 2020
6
Characteristics of Chronic Cough in adults in Pakistani population: A cross sectional study. 61
32292434 2020
7
Diagnostic value of fractional exhaled nitric oxide in cough-variant asthma: an updated meta-analysis. 61
30706744 2020
8
Identification of quality control markers in Suhuang antitussive capsule based on HPLC-PDA fingerprint and anti-inflammatory screening. 61
31901736 2020
9
Current Status and Future Directions of Chronic Cough in China. 61
31912413 2020
10
Clinical Characteristics of Chronic Cough in Korea. 61
31905430 2020
11
Arnold Nerve Reflex: Vagal Hypersensitivity in Chronic Cough With Various Causes. 61
31945317 2020
12
ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. 61
31515408 2020
13
lncRNA PCGEM1 strengthens anti-inflammatory and lung protective effects of montelukast sodium in children with cough-variant asthma. 61
32520202 2020
14
A traditional Chinese patent medicine-Suhuang zhike capsule for cough variant asthma in adults: A protocol of systematic review and meta-analysis of randomized controlled trials. 61
31852128 2019
15
Diagnostic value of FeNO and MMEF for predicting cough variant asthma in chronic cough patients with or without allergic rhinitis. 61
31820665 2019
16
Heterogeneity of perception of symptoms in patients with asthma. 61
32030239 2019
17
Classification of asthma. 61
31690376 2019
18
Value of Exhaled Nitric Oxide and FEF25-75 in Identifying Factors Associated With Chronic Cough in Allergic Rhinitis. 61
31552718 2019
19
Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity. 61
31552721 2019
20
Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough. 61
31182314 2019
21
Reflux characteristics in patients with gastroesophageal reflux-related chronic cough complicated by laryngopharyngeal reflux. 61
31807511 2019
22
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. 61
31315072 2019
23
[The Mysterious Cough - a Case-Based Proposal of Differential Diagnosis]. 61
31480953 2019
24
Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation. 61
31259654 2019
25
Characteristics of Chinese chronic cough patients. 61
31176802 2019
26
Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China. 61
31559054 2019
27
Etiologies associated with chronic cough and its clinical characteristics in school-age children. 61
31463138 2019
28
Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum. 61
31258680 2019
29
Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway. 61
31354164 2019
30
Fractional Exhaled Nitric Oxide (FeNO) Combined with Pulmonary Function Parameters Shows Increased Sensitivity and Specificity for the Diagnosis of Cough Variant Asthma in Children. 61
31120043 2019
31
[Causes of chronic cough in children in Chongqing, China: an analysis of 202 cases]. 61
31104658 2019
32
Montelukast and Budesonide for Childhood Cough Variant Asthma. 61
30925958 2019
33
Chronic cough and obesity. 61
30817992 2019
34
[Clinical effect of fluticasone propionate, montelukast sodium and ketotifen in treatment of cough variant asthma in children]. 61
31014435 2019
35
Cromolyn, a New Hope for Limited Treatment of Neutrophilic Asthma: a Phase II Randomized Clinical Trial. 61
32411260 2019
36
Upper airway cough syndrome in 103 children. 61
30855345 2019
37
[The role of leukotriene in the pathogenesis of cough variant asthma]. 61
30845400 2019
38
Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs. 61
30415484 2019
39
[Do not diagnose postinfectious cough as cough variant asthma]. 61
30845390 2019
40
Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system. 61
30808365 2019
41
Chinese herbal medicine for the treatment of cough variant asthma: a study protocol for a double-blind randomized controlled trial. 61
30606237 2019
42
A retrospective study of clinical features of cough variant asthma in Chinese adults. 61
30675172 2019
43
Clinical and pulmonary function changes in cough variant asthma with small airway disease. 61
31303871 2019
44
A breath sound analysis in children with cough variant asthma. 61
29857933 2019
45
Etiology analysis of nonspecific chronic cough in children of 5 years and younger. 61
30653096 2019
46
Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion. 61
31920638 2019
47
Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough. 61
30746207 2018
48
Functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma. 61
30546407 2018
49
An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids. 61
30728339 2018
50
Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease? 61
28917529 2018

Variations for Cough Variant Asthma

Expression for Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for Cough Variant Asthma

Pathways related to Cough Variant Asthma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 RNASE3 IL5 IL4 IL13
2
Show member pathways
12.31 IL5 IL4 IL13 IGHE
3
Show member pathways
12.01 NGF IL5 IL4 IL13
4 11.91 TAC1 NGF IL13
5 11.74 IL4 IL13 IGHE
6 11.55 IL5 IL4 IL13
7 11.51 IL5 IL4 IL13
8 11.38 IL5 IL4 IL13
9 11.34 IL5 IL4 IGHE
10 11.16 IL5 IL4 IL13
11 10.94 IL5 IL4 IL13
12 10.79 IL5 IL4 IL13
13 10.75 NGF IL5 IL4 IL13
14 10.55 IL5 IL4 IL13
15 9.88 IL5 IL4 IL13

GO Terms for Cough Variant Asthma

Cellular components related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TAC1 RNASE3 NGF IL5 IL4 IL13
2 external side of plasma membrane GO:0009897 9.46 TRPV1 IL13 IGHE ACE
3 extracellular region GO:0005576 9.28 TTLL1 TAC1 RNASE3 NGF IL5 IL4

Biological processes related to Cough Variant Asthma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 IL5 IL4 IL13 IGHE
2 inflammatory response GO:0006954 9.81 TRPV1 TAC1 IL5 IL13
3 innate immune response in mucosa GO:0002227 9.56 RNASE3 IL4
4 cytokine-mediated signaling pathway GO:0019221 9.56 IL5 IL4 IL13 IGHE
5 response to pain GO:0048265 9.54 TRPV1 TAC1
6 cellular sodium ion homeostasis GO:0006883 9.52 ATP4A ATP12A
7 sodium ion export across plasma membrane GO:0036376 9.49 ATP4A ATP12A
8 cellular potassium ion homeostasis GO:0030007 9.48 ATP4A ATP12A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.46 ATP4A ATP12A
10 macrophage activation GO:0042116 9.43 IL4 IL13
11 negative regulation of heart rate GO:0010459 9.4 TRPV1 TAC1
12 positive regulation of interleukin-10 secretion GO:2001181 9.37 IL4 IL13
13 positive regulation of mast cell degranulation GO:0043306 9.32 IL4 IL13
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL4 IL13
15 positive regulation of B cell proliferation GO:0030890 9.13 IL5 IL4 IL13
16 microglial cell activation GO:0001774 8.8 TRPV1 IL4 IL13

Molecular functions related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 NGF IL5 IL4
2 cytokine receptor binding GO:0005126 9.32 IL4 IL13
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
5 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Cough Variant Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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