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MCID: CGH001
MIFTS: 34

Cough Variant Asthma

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cough Variant Asthma

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MalaCards integrated aliases for Cough Variant Asthma:

Name: Cough Variant Asthma 12 15 72

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12323
ICD9CM 35 493.82
ICD10 33 J45.991
UMLS 72 C0694548
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Summaries for Cough Variant Asthma

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Disease Ontology : 12 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary : Cough Variant Asthma is related to bronchitis and hypereosinophilic syndrome. An important gene associated with Cough Variant Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Allograft rejection and Immune response IFN alpha/beta signaling pathway. The drugs Budesonide and Procaterol have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and trachea.

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Related Diseases for Cough Variant Asthma

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Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 bronchitis 30.7 RNASE3 IL5
2 hypereosinophilic syndrome 30.3 RNASE3 IL5 IL4
3 asthma 30.2 RNASE3 NGF IL5 IL4
4 allergic hypersensitivity disease 30.1 RNASE3 IL5 IL4
5 allergic bronchopulmonary aspergillosis 30.1 IL5 IL4
6 aspergillosis 30.1 IL5 IL4
7 ige responsiveness, atopic 30.1 RNASE3 IL5 IL4
8 allergic asthma 29.7 RNASE3 IL5 IL4
9 rhinitis 29.4 RNASE3 NGF IL5 IL4
10 allergic rhinitis 29.4 RNASE3 NGF IL5 IL4
11 loeffler endocarditis 10.4 RNASE3 IL5
12 paragonimiasis 10.4 RNASE3 IL5
13 cow milk allergy 10.4 RNASE3 IL5
14 eosinophilic gastroenteritis 10.3 RNASE3 IL5
15 chronic eosinophilic pneumonia 10.3 RNASE3 IL5
16 eosinophilic pneumonia 10.3 RNASE3 IL5
17 status asthmaticus 10.3 RNASE3 IL5
18 blepharoconjunctivitis 10.3 RNASE3 IL4
19 giant papillary conjunctivitis 10.3 RNASE3 IL4
20 vasculogenic impotence 10.3 RNASE3 ACE
21 pollen allergy 10.3 RNASE3 IL5
22 otitis media 10.3 RNASE3 IL4
23 wells syndrome 10.3 RNASE3 IL5
24 churg-strauss syndrome 10.3 RNASE3 IL5
25 nickel allergic contact dermatitis 10.3 IL5 IL4
26 allergic contact dermatitis 10.3 IL5 IL4
27 contact dermatitis 10.3 IL5 IL4
28 egg allergy 10.2 IL5 IL4
29 scleritis 10.2 IL5 IL4
30 sulfamethoxazole allergy 10.2 IL5 IL4
31 cellulitis 10.2 RNASE3 IL5
32 trichinosis 10.2 IL5 IL4
33 angiostrongyliasis 10.2 IL5 IL4
34 apple allergy 10.2 IL5 IL4
35 neuroretinitis 10.2 RNASE3 ACE
36 gaucher disease, type ii 10.2 IL5 IL4
37 non-suppurative otitis media 10.2 IL5 IL4
38 eosinophilic meningitis 10.2 IL5 IL4
39 prurigo nodularis 10.2 RNASE3 NGF
40 eosinophilic gastritis 10.2 IL5 IL4
41 filarial elephantiasis 10.2 IL5 IL4
42 chronic tic disorder 10.2 IL5 IL4
43 intestinal schistosomiasis 10.2 IL5 IL4
44 toxic oil syndrome 10.2 IL5 IL4
45 vernal conjunctivitis 10.2 RNASE3 IL4
46 folliculitis 10.2 IL5 IL4
47 common cold 10.2 RNASE3 IL5
48 enterobiasis 10.2 IL5 IL4
49 conjunctival nevus 10.2 RNASE3 NGF
50 granulomatous angiitis 10.2 IL5 ACE

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to Cough Variant Asthma
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Symptoms & Phenotypes for Cough Variant Asthma

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Drugs & Therapeutics for Cough Variant Asthma

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Drugs for Cough Variant Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 4 51333-22-3 63006 5281004
2
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
3
Terbutaline Approved Phase 4 23031-25-6 5403
4
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
5
Chlorpheniramine Approved Phase 4 132-22-9, 113-92-8 2725
6
Ephedrine Approved Phase 4 299-42-3 9294
7
Pseudoephedrine Approved Phase 4 90-82-4 7028
8
Montelukast Approved Phase 4 158966-92-8 5281040
9
Bambuterol Investigational Phase 4 81732-65-2, 81732-46-9 54766
10 Sympathomimetics Phase 4
11 Adrenergic Agonists Phase 4
12 Adrenergic beta-Agonists Phase 4
13 glucocorticoids Phase 4
14 Adrenergic beta-2 Receptor Agonists Phase 4
15 Adrenergic Agents Phase 4
16 Bronchodilator Agents Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Formoterol Fumarate Phase 4
19 Budesonide, Formoterol Fumarate Drug Combination Phase 4
20 Tocolytic Agents Phase 4
21 Adrenergic alpha-Agonists Phase 4
22 Nasal Decongestants Phase 4
23 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
24 Anti-Obesity Agents Phase 4
25 Expectorants Phase 4
26 Vasoconstrictor Agents Phase 4
27 Antitussive Agents Phase 4
28 Appetite Depressants Phase 4
29 Anti-Asthmatic Agents Phase 4
30 Hormones Phase 4
31 Hormone Antagonists Phase 4
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
33 Cytochrome P-450 Enzyme Inducers Phase 4
34 Leukotriene Antagonists Phase 4
35 Neurotransmitter Agents Phase 4
36 Peripheral Nervous System Agents Phase 4
37 Respiratory System Agents Phase 4
38 Autonomic Agents Phase 4
39 Cholinergic Agents Phase 4
40 Muscarinic Agonists Phase 4
41 Methacholine Chloride Phase 4
42
Fenofibrate Approved 49562-28-9 3339
43
Nitric Oxide Approved 10102-43-9 145068
44
Prednisone Approved, Vet_approved 53-03-2 5865
45
Capsaicin Approved 404-86-4 1548943
46
Mannitol Approved, Investigational 69-65-8 453 6251
47 Free Radical Scavengers
48 Antioxidants
49 Protective Agents
50 Endothelium-Dependent Relaxing Factors

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Multicentered, Double-blinded, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Procaterol Hydrochloride With Inhaled Glucocorticoid in Treatment Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
2 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
3 Randomised, Open-label, Parallel-group Study of the Response to Bronchodilator Treatment in Subjects With Eosinophilic Bronchitis and the Mechanism of Varied Responses to Bronchodilator Treatment. Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
4 Randomised, Double-blinded, Placebo-Controlled Study of Therapeutic Effect of Su-Huang Antitussive Capsule on Cough Variant Asthma(CVA) Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
5 Randomised, Open-label, Parallel-group Study of Therapeutic Effect of Leukotriene Modulator Montelukast Alone or Combined With Inhaled Corticosteroid on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
6 The Effects of Alvokast (Montelukast) in Patients With Chronic Cough Completed NCT01754220 Phase 4 Montelukast
7 Prospective Single-centre, Double Blind Randomised Trial of Montelukast in Patients With Chronic Cough and Bronchial Hyperreactivity Completed NCT00453765 Phase 4 montelukast;placebo
8 Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline in Individuals With Cough Variant Asthma and Chronic Cough Not yet recruiting NCT03105843 Phase 4 Methacholine (MCh) Challenge Testing
9 Longitudinal Study of Children With a Chronic Cough and the Impact of Gastroesophageal Reflux Withdrawn NCT00771706 Phase 3 Proton Pump Inhibitor;Placebo
10 Observation of the Respiratory Impedance and Inflammation in Cough Variant Asthma Patients Treated in Combination of Chanqin Granules. Unknown status NCT03319043 Phase 1, Phase 2 Chanqin granules
11 Difference in Gene Expression Profile in Peripheral Blood Mononuclear Cells and Inflammation Profile in Patients With Classic Asthma, Cough Variant Asthma, and Eosinophilic Bronchitis Compared With Healthy Controls Unknown status NCT02555345
12 Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data Unknown status NCT03169699
13 A Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Patient Aged 5-Year Old or Younger in Outpatient Department Completed NCT00660114
14 Bronchodilating and Bronchoprotective Effects of Deep Inspirations in Asthma, Cough Variant Asthma and Chronic Cough With Normal Airway Sensitivity and Sensory-Mechanical Responses to High-Dose Methacholine in Healthy Normal Subjects Completed NCT01659476
15 Evaluating the Efficacy of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma Recruiting NCT03573284
16 The Usefulness of the Methacholine Challenge Test and Capsaicin Inhalation Cough Challenge in a Prediction of Response to Management in Adults With a Chronic Cough. Recruiting NCT03363698
17 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting NCT01064245 high-dose methacholine challenge test

Search NIH Clinical Center for Cough Variant Asthma

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Genetic Tests for Cough Variant Asthma

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Anatomical Context for Cough Variant Asthma

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MalaCards organs/tissues related to Cough Variant Asthma:

41
Testes, Lung, Trachea, Endothelial
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Publications for Cough Variant Asthma

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Articles related to Cough Variant Asthma:

(show top 50) (show all 340)
# Title Authors PMID Year
1
Characteristics of Chinese chronic cough patients. 38
31176802 2019
2
Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum. 38
31258680 2019
3
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. 38
31315072 2019
4
Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway. 38
31354164 2019
5
Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation. 38
31259654 2019
6
Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough. 38
31182314 2019
7
[Causes of chronic cough in children in Chongqing, China: an analysis of 202 cases]. 38
31104658 2019
8
Fractional Exhaled Nitric Oxide (FeNO) Combined with Pulmonary Function Parameters Shows Increased Sensitivity and Specificity for the Diagnosis of Cough Variant Asthma in Children. 38
31120043 2019
9
[Clinical effect of fluticasone propionate, montelukast sodium and ketotifen in treatment of cough variant asthma in children]. 38
31014435 2019
10
Chronic cough and obesity. 38
30817992 2019
11
Montelukast and Budesonide for Childhood Cough Variant Asthma. 38
30925958 2019
12
[Do not diagnose postinfectious cough as cough variant asthma]. 38
30845390 2019
13
Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs. 38
30415484 2019
14
[The role of leukotriene in the pathogenesis of cough variant asthma]. 38
30845400 2019
15
Upper airway cough syndrome in 103 children. 38
30855345 2019
16
Diagnostic value of fractional exhaled nitric oxide in cough-variant asthma: an updated meta-analysis. 38
30706744 2019
17
Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system. 38
30808365 2019
18
Chinese herbal medicine for the treatment of cough variant asthma: a study protocol for a double-blind randomized controlled trial. 38
30606237 2019
19
A retrospective study of clinical features of cough variant asthma in Chinese adults. 38
30675172 2019
20
Clinical and pulmonary function changes in cough variant asthma with small airway disease. 38
31303871 2019
21
Etiology analysis of nonspecific chronic cough in children of 5 years and younger. 38
30653096 2019
22
A breath sound analysis in children with cough variant asthma. 38
29857933 2019
23
Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough. 38
30746207 2018
24
Functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma. 38
30546407 2018
25
An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids. 38
30728339 2018
26
Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease? 38
28917529 2018
27
Pearls and pitfalls in the diagnosis of cough variant asthma. 38
30401324 2018
28
Sputum interleukin-25 correlates with asthma severity: a preliminary study. 38
30429702 2018
29
Pattern of Response to Bronchial Challenge with Histamine in Patients with Non-Atopic Cough-Variant and Classic Asthma. 38
30002276 2018
30
Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma. 38
28846444 2018
31
Montelukast and budesonide combination for children with chronic cough-variant asthma. 38
30045280 2018
32
Animal Derived Thiol Induced Work Exacerbated Asthma: A Brief Case Report of a Unique Workplace Hazard. 38
30623404 2018
33
[Thought and method of classic formulae in treatment of chronic cough]. 38
29950056 2018
34
WeChat Public Account Use Improves Clinical Control of Cough-Variant Asthma: A Randomized Controlled Trial. 38
29536984 2018
35
Role of prostaglandin E2 in bronchoconstriction-triggered cough response in guinea pigs. 38
28951192 2018
36
Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide. 38
27731932 2018
37
[USEFULNESS OF THE FORCED OSCILLATION TECHNIQUE IN THE DIAGNOSIS OF COUGH VARIANT ASTHMA WITH PROLONGED OR CHRONIC COUGH]. 38
30022785 2018
38
[PROBLEMS ASSOCIATED WITH THE DIAGNOSIS OF PROLONGED/CHRONIC COUGH IN CLINICAL SETTINGS]. 38
30146625 2018
39
[THE CAUSES OF ACUTE COUGH: A SINGLE-CENTER STUDY IN JAPAN]. 38
29459525 2018
40
A lung sound analysis in a child thought to have cough variant asthma: A case report. 38
28673440 2018
41
Therapeutic Effects of Kangzhi Syrup in a Guinea Pig Model of Ovalbumin-Induced Cough Variant Asthma. 38
29951106 2018
42
Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis. 38
28088474 2017
43
Anoectochilus roxburghii: A review of its phytochemistry, pharmacology, and clinical applications. 38
28755972 2017
44
Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma. 38
28778200 2017
45
[Evaluating the efficacy of fractional exhaled nitric oxide and impulse oscillometry in screening out cough variant asthma from patients with subacute cough]. 38
28822450 2017
46
The measurement of cough response to bronchoconstriction induced by methacholine inhalation in healthy subjects: An examination using the Astograph method. 38
28718683 2017
47
Correlation study of cough variant asthma and mycoplasma pneumonia infection in children. 38
28671088 2017
48
Diagnostic utility of fractional exhaled nitric oxide in prolonged and chronic cough according to atopic status. 38
27693513 2017
49
[Micro-invasive embedding combined with montelukast sodium for children cough variant asthma:a randomized controlled trial]. 38
29231431 2017
50
[Comparison of functional parameters of small airways between patients with typical asthma and cough-variant asthma]. 38
28377348 2017
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Variations for Cough Variant Asthma

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Expression for Cough Variant Asthma

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Search GEO for disease gene expression data for Cough Variant Asthma.
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Pathways for Cough Variant Asthma

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Pathways related to Cough Variant Asthma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 37 1
Show member pathways
 12.46 RNASE3 IL5 IL4
2
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.71 NGF IL5 IL4
3
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.59 NGF IL5 IL4
4
Hematopoietic cell lineage 37
11.52 IL5 IL4
5
Glucocorticoid receptor regulatory network 1
11.42 IL5 IL4
6
Innate Lymphoid Cell Differentiation Pathways 65
11.4 IL5 IL4
7
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.36 IL5 IL4
8
Lung fibrosis 1
11.26 IL5 IL4
9
IL4-mediated signaling events 1
11.23 IL5 IL4
10
Th2 Differentiation Pathway 65
11.03 IL5 IL4
11
Inflammatory Response Pathway 1
10.78 IL5 IL4
12
Development and heterogeneity of the ILC family 1
10.66 IL5 IL4
13
G-protein signaling_Rap2B regulation pathway 22
10.6 NGF IL5 IL4
14
Cytokines and Inflammatory Response 1
10.42 IL5 IL4
15
OX40 Pathway 64
10.04 IL5 IL4
Sources

GO Terms for Cough Variant Asthma

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Cellular components related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 RNASE3 NGF IL5 IL4 ACE
2 extracellular space GO:0005615 9.02 RNASE3 NGF IL5 IL4 ACE

Biological processes related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of B cell proliferation GO:0030890 8.62 IL5 IL4

Molecular functions related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 NGF IL5 IL4
Sources

Sources for Cough Variant Asthma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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