YABA
MCID: CWP001
MIFTS: 43

Cowpox (YABA)

Categories: Infectious diseases, Skin diseases
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Aliases & Classifications for Cowpox

MalaCards integrated aliases for Cowpox:

Name: Cowpox 11 75 53 43 14 16 71 33
Yaba 11

Classifications:



External Ids:

Disease Ontology 11 DOID:8956
ICD9CM 34 051.01
MeSH 43 D015605
SNOMED-CT 68 154344005
ICD11 33 1205745537
UMLS 71 C0010232

Summaries for Cowpox

Disease Ontology: 11 A viral infectious disease that results in infection in rodents, cows, and humans, located in skin, has material basis in Cowpox virus, which is transmitted by contact with an infected animal. The infection results in formation of vesicopustular lesions on the hands or face.

MalaCards based summary: Cowpox, also known as yaba, is related to vaccinia and stomatitis. An important gene associated with Cowpox is CASP1 (Caspase 1), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. Affiliated tissues include skin, t cells and ovary, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Wikipedia: 75 Cowpox is an infectious disease caused by the cowpox virus (CPXV). It presents with large blisters in... more...

Related Diseases for Cowpox

Diseases related to Cowpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 291)
# Related Disease Score Top Affiliating Genes
1 vaccinia 31.3 IL6 GZMB EIF2S1 CD80
2 stomatitis 30.7 MX1 IL6 CXCL8
3 viral infectious disease 30.3 TNFRSF1A MX1 KLRK1 IL6 GZMB FAS
4 lymphadenitis 30.2 IL6 FAS CXCL8 CASP3
5 yellow fever 30.1 IL6 EIF2S1 CXCL1 CASP3
6 cellulitis 30.1 IL6 CXCL8 CD8A
7 viral encephalitis 30.0 MX1 IL6 CD8A
8 bronchopneumonia 30.0 IL6 CXCL8 CD8A
9 keratitis, hereditary 30.0 IL6 CXCL8 CXCL1 CD8A
10 tularemia 29.9 IL6 CD8A CASP1
11 respiratory failure 29.9 IL6 CXCL8 CXCL1 CD8A
12 tonsillitis 29.8 IL6 CXCL8 CXCL1 CASP3
13 pneumonia 29.8 IL6 CXCL8 CXCL1 CD8A
14 dengue disease 29.8 IL6 CXCL8 CD8A
15 human cytomegalovirus infection 29.8 KLRK1 IL6 CD8A
16 tracheitis 29.8 IL6 CXCL8 CD8A
17 exanthem 29.7 IL6 CXCL8 CD8A
18 autoimmune disease 29.5 TNFRSF1A KLRK1 IL6 FAS CD86 CD80
19 osteogenic sarcoma 29.4 XIAP IL6 CASP8 CASP3
20 dermatitis, atopic 29.4 IL6 CXCL8 CD8A CD86
21 panniculitis 29.3 GZMB FAS CD8A CASP3
22 skin disease 28.4 TNFRSF1A MX1 IL6 GZMB CXCL8 CXCL1
23 human infection by orthopoxvirus 11.0
24 smallpox 10.8
25 monkeypox 10.5
26 acute generalized exanthematous pustulosis 10.3 MX1 CXCL8
27 goat milk allergy 10.3 CD86 CD80
28 acute pericementitis 10.3 IL6 CXCL8
29 fuchs' heterochromic uveitis 10.3 IL6 CXCL8
30 necrotizing ulcerative gingivitis 10.3 IL6 CXCL8
31 adult-onset still's disease 10.3 IL6 IL18BP CASP1
32 paracoccidioidomycosis 10.3 IL6 CXCL8 CD86
33 acute cystitis 10.2 IL6 CXCL8 CXCL1
34 cystitis 10.2 IL6 CXCL8 CXCL1
35 bacteriuria 10.2 IL6 CXCL8 CXCL1
36 fibroma 10.2
37 brucellosis 10.2 IL6 CXCL8 CD86
38 bronchiolitis obliterans 10.2 IL6 CXCL8 CD80
39 chlamydia 10.2 IL6 CXCL8 CASP1
40 osteomyelitis 10.2 IL6 CXCL8 CASP1
41 endometritis 10.2 IL6 CXCL8 CXCL1
42 peptic ulcer disease 10.2 IL6 CXCL8 CXCL1
43 urethral syndrome 10.2 IL6 CXCL8 CXCL1
44 periodic fever, familial, autosomal dominant 10.2 TNFRSF1A IL6 CASP1
45 encephalomalacia 10.2 IL6 CXCL8 CASP3
46 periventricular leukomalacia 10.2 IL6 CXCL8 CASP3
47 duodenal ulcer 10.2 IL6 CXCL8 CXCL1
48 lymphocytic choriomeningitis 10.2 IL6 CXCL8 CD86 CD80
49 proteasome-associated autoinflammatory syndrome 1 10.2 IL6 CXCL8 CXCL1
50 muckle-wells syndrome 10.2 TNFRSF1A CXCL8 CASP1

Graphical network of the top 20 diseases related to Cowpox:



Diseases related to Cowpox

Symptoms & Phenotypes for Cowpox

GenomeRNAi Phenotypes related to Cowpox according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.21 CASP3 CXCL8 EIF2S1 FAS GZMB TNFRSF1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.21 CASP1 CASP3 CASP4 CASP5 CXCL8 EIF2S1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 10.21 CASP8
4 no effect GR00402-S-1 10.15 CASP1 CASP3 CASP4 CASP5 CASP8 CD80
5 no effect GR00402-S-2 10.15 CASP1 CASP3 CASP4 CASP5 CASP8 CD86

MGI Mouse Phenotypes related to Cowpox:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 CASP1 CASP3 CASP4 CASP5 CASP8 CD86
2 nervous system MP:0003631 10.32 CASP1 CASP3 CASP4 CASP5 CASP8 CD80
3 endocrine/exocrine gland MP:0005379 10.28 CASP1 CASP3 CASP4 CASP5 CASP8 CD80
4 immune system MP:0005387 10.23 CASP1 CASP3 CASP4 CASP5 CASP8 CD80
5 cellular MP:0005384 10.21 CASP1 CASP3 CASP4 CASP5 CASP8 CD80
6 renal/urinary system MP:0005367 10.19 CASP1 CASP3 CASP4 CASP5 CASP8 CD8A
7 neoplasm MP:0002006 10.18 CASP1 CASP4 CASP5 CASP8 FAS GZMB
8 hematopoietic system MP:0005397 10.13 CASP1 CASP3 CASP4 CASP5 CASP8 CD80
9 cardiovascular system MP:0005385 10.1 CASP1 CASP3 CASP4 CASP5 CASP8 CXCL1
10 muscle MP:0005369 10.08 CASP3 CASP8 CD86 FAS IL6 TNFRSF1A
11 digestive/alimentary MP:0005381 10.01 CASP1 CASP3 CASP4 CASP5 FAS IL6
12 mortality/aging MP:0010768 9.83 CASP1 CASP3 CASP4 CASP5 CASP8 CD8A
13 integument MP:0010771 9.4 CASP1 CASP3 CASP4 CASP5 CASP8 CD8A

Drugs & Therapeutics for Cowpox

Cochrane evidence based reviews: cowpox

Genetic Tests for Cowpox

Anatomical Context for Cowpox

Organs/tissues related to Cowpox:

FMA: Skin
MalaCards : Skin, T Cells, Ovary, Kidney, Adrenal Cortex, Monocytes, B Cells

Publications for Cowpox

Articles related to Cowpox:

(show top 50) (show all 1265)
# Title Authors PMID Year
1
Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation. 53 62
16636047 2006
2
Alkylphosphocholine-induced glioma cell death is BCL-X(L)-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation. 53 62
15389288 2004
3
Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells. 53 62
15475455 2004
4
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL. 53 62
14645670 2003
5
Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins. 53 62
12667137 2003
6
CrmE, a novel soluble tumor necrosis factor receptor encoded by poxviruses. 53 62
11119592 2001
7
Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins. 53 62
10769064 2000
8
Hepatitis C virus core protein does not inhibit apoptosis in human hepatoma cells. 53 62
10583438 1999
9
Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates. 53 62
10440063 1999
10
Uncouplers of oxidative phosphorylation can enhance a Fas death signal. 53 62
10207055 1999
11
Inhibition of human caspases by peptide-based and macromolecular inhibitors. 53 62
9829999 1998
12
A third distinct tumor necrosis factor receptor of orthopoxviruses. 53 62
9520445 1998
13
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases. 53 62
16465268 1997
14
Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. 53 62
9269989 1997
15
Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. 53 62
9144192 1997
16
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. 53 62
8972182 1997
17
Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA. 53 62
8793301 1996
18
Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 53 62
7868902 1995
19
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 53 62
8034697 1994
20
Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses. 62
36414175 2023
21
Orthopoxvirus Seroprevalence and Infection Susceptibility in France, Bolivia, Laos, and Mali. 62
36343384 2022
22
Monkeypox as an emerging infectious disease: the ophthalmic implications. 62
36216412 2022
23
Necrotic facial ulceration caused by cowpox virus. 62
36458564 2022
24
Line-field confocal optical coherence tomography imaging of human cowpox virus skin infection. 62
35855673 2022
25
William chambers: British army surgeon (Toulon, 1793) and his vaccination institution (1803) in Brighton, England. 62
33641509 2022
26
Monkeypox. 62
36403582 2022
27
Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. 62
36222522 2022
28
Evaluation of Rapid Dot-Immunoassay for Detection Orthopoxviruses Using Laboratory-Grown Viruses and Animal's Clinical Specimens. 62
36423189 2022
29
The effective factors in human-specific tropism and viral pathogenicity in orthopoxviruses. 62
36317465 2022
30
Multiple mechanisms for overcoming lethal over-initiation of DNA replication. 62
36053906 2022
31
[Determination of the optimal immunizing dose of heterologous goat pox virus vaccine (Poxviridae: Chordopoxvirinae: Capripoxvirus) against lumpy skin disease]. 62
36097711 2022
32
Enhancement of live vaccines by co-delivery of immune modulating proteins. 62
36064671 2022
33
Genomic Sequencing and Phylogenomics of Cowpox Virus. 62
36298689 2022
34
The secreted protein Cowpox Virus 14 contributes to viral virulence and immune evasion by engaging Fc-gamma-receptors. 62
36121874 2022
35
Monkeypox, a Literature Review: What Is New and Where Does This concerning Virus Come From? 62
36146705 2022
36
The presumed receptivity and susceptibility to monkeypox of European animal species. 62
35753629 2022
37
Monkeypox: The Re-emerging Terror. 62
36185856 2022
38
Genetic ancestry and population structure of vaccinia virus. 62
35953491 2022
39
Genome stability of the vaccine strain VACΔ6. 62
35903306 2022
40
Design, Synthesis, and Biological Evaluation of (+)-Camphor- and (-)-Fenchone-Based Derivatives as Potent Orthopoxvirus Inhibitors. 62
35388614 2022
41
A Belgian student with black eschars. 62
35731612 2022
42
Structure and kinase activity of bacterial cell cycle regulator CcrZ. 62
35576203 2022
43
Dr. James Smith's Dream of Eradicating Smallpox and the National Vaccine Institution. 62
35577219 2022
44
Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance. 62
35327382 2022
45
Life and death of smallpox. 62
35143880 2022
46
Transmission dynamics of Monkeypox virus: a mathematical modelling approach. 62
34667829 2022
47
Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses. 62
34949827 2022
48
Genomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus. 62
35592007 2022
49
The Disease Ecology, Epidemiology, Clinical Manifestations, Management, Prevention, and Control of Increasing Human Infections with Animal Orthopoxviruses. 62
34563454 2021
50
Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity. 62
33965861 2021

Variations for Cowpox

Expression for Cowpox

Search GEO for disease gene expression data for Cowpox.

Pathways for Cowpox

Pathways related to Cowpox according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNFRSF1A MX1 KLRK1 IL6 IL18BP CXCL8
2
Show member pathways
13.86 CASP1 CASP3 CASP4 CASP5 CASP8 EIF2S1
3 13.79 CASP3 CASP8 CD80 CD86 CXCL1 CXCL8
4
Show member pathways
13.64 TNFRSF1A IL6 FAS CXCL8 CXCL1 CD80
5
Show member pathways
13.43 CASP3 CD80 CXCL1 CXCL8 FAS IL6
6
Show member pathways
13.25 CASP1 CASP3 CASP8 CD80 CD86 CXCL1
7
Show member pathways
13.21 TNFRSF1A IL6 FAS CXCL8 CXCL1 CD80
8
Show member pathways
12.92 XIAP TNFRSF1A GZMB FAS CASP8 CASP5
9
Show member pathways
12.88 XIAP TNFRSF1A FAS CASP8 CASP3
10
Show member pathways
12.86 TNFRSF1A IL6 FAS EIF2S1 CASP8 CASP3
11
Show member pathways
12.8 TNFRSF1A GZMB FAS CASP8 CASP3 CASP1
12
Show member pathways
12.75 CASP3 CASP8 CD80 CD86 CXCL8 EIF2S1
13
Show member pathways
12.65 XIAP GZMB FAS CASP8 CASP5 CASP4
14
Show member pathways
12.64 CASP1 CASP3 CASP4 CASP5 CASP8 FAS
15
Show member pathways
12.63 MX1 IL6 CXCL8 CASP8 CASP3
16
Show member pathways
12.53 XIAP CASP8 CASP5 CASP4 CASP3 CASP1
17
Show member pathways
12.51 IL6 CXCL8 CASP5 CASP1
18
Show member pathways
12.42 IL6 FAS CXCL8 CASP1
19
Show member pathways
12.4 XIAP TNFRSF1A FAS CASP8 CASP3
20
Show member pathways
12.31 IL6 CXCL8 CXCL1 CASP8 CASP3
21
Show member pathways
12.26 XIAP GZMB CASP8 CASP3
22
Show member pathways
12.23 FAS CASP8 CASP5 CASP4 CASP3 CASP1
23
Show member pathways
12.22 XIAP TNFRSF1A GZMB FAS CASP8 CASP4
24 12.16 CASP8 CASP5 CASP4 CASP3 CASP1
25
Show member pathways
12.06 CASP1 CASP3 CASP4 CASP5 CASP8 TNFRSF1A
26 12.05 KLRK1 IL6 CD8A CD86 CD80
27 12.03 IL6 CXCL8 CXCL1 CASP3
28 12 CASP8 CASP5 CASP4 CASP3 CASP1
29 11.93 IL6 CXCL8 CXCL1
30
Show member pathways
11.91 IL6 CD86 CD80
31
Show member pathways
11.91 CD80 CD86 GZMB IL6
32 11.89 IL6 CXCL8 CASP8
33
Show member pathways
11.88 CASP8 CASP4 CASP1
34
Show member pathways
11.87 CXCL1 CXCL8 IL6
35
Show member pathways
11.83 IL6 CXCL8 CD8A CASP3
36 11.81 IL6 CXCL8 CXCL1 CASP3
37 11.8 KLRK1 GZMB CD8A
38
Show member pathways
11.77 XIAP GZMB FAS CASP8 CASP5 CASP4
39 11.76 CASP3 CD80 IL6
40
Show member pathways
11.68 TNFRSF1A IL6 CXCL8
41 11.67 IL6 GZMB CXCL8
42 11.67 CASP3 CASP8 CD80 CD86 CXCL8 FAS
43 11.63 MX1 CXCL8 CXCL1 CASP8
44
Show member pathways
11.63 XIAP TNFRSF1A GZMB FAS CASP8 CASP5
45 11.62 IL6 CXCL8 CASP3
46 11.61 CASP3 CASP8 FAS TNFRSF1A
47
Show member pathways
11.6 CASP3 CASP8 GZMB
48 11.58 TNFRSF1A IL6 CXCL8
49 11.54 TNFRSF1A IL6 FAS EIF2S1 CASP8
50 11.51 XIAP CASP8 CASP5 CASP1

GO Terms for Cowpox

Cellular components related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AIM2 inflammasome complex GO:0097169 9.62 CASP4 CASP1
2 CD95 death-inducing signaling complex GO:0031265 9.56 FAS CASP8
3 IPAF inflammasome complex GO:0072557 9.46 CASP4 CASP1
4 NLRP1 inflammasome complex GO:0072558 9.26 CASP5 CASP1
5 death-inducing signaling complex GO:0031264 9.1 FAS CASP8 CASP3

Biological processes related to Cowpox according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 10.25 ZMPSTE24 GZMB CASP8 CASP5 CASP4 CASP3
2 immune response GO:0006955 10.11 CD80 CD86 CD8A CXCL1 CXCL8 FAS
3 regulation of inflammatory response GO:0050727 10.1 XIAP CASP5 CASP4 CASP1
4 regulation of apoptotic process GO:0042981 10.06 XIAP FAS CASP8 CASP5 CASP4 CASP1
5 apoptotic signaling pathway GO:0097190 10.01 CASP8 CASP5 CASP3 CASP1
6 T cell costimulation GO:0031295 10 KLRK1 CD86 CD80
7 cellular response to mechanical stimulus GO:0071260 9.96 TNFRSF1A FAS CASP8 CASP5 CASP1
8 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.93 CASP1 CASP4 CASP5 CASP8
9 defense response GO:0006952 9.91 TNFRSF1A MX1 CXCL8 CXCL1
10 apoptotic process GO:0006915 9.91 XIAP TNFRSF1A MX1 GZMB FAS CASP8
11 response to cobalt ion GO:0032025 9.84 CASP8 CASP3
12 positive regulation of type B pancreatic cell apoptotic process GO:2000676 9.78 IL6 EIF2S1
13 pyroptosis GO:0070269 9.76 CASP1 CASP4 CASP8 GZMB
14 cellular response to lipopolysaccharide GO:0071222 9.47 KLRK1 IL6 CXCL8 CXCL1 CD86 CD80

Molecular functions related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase activity GO:0004197 10.07 CASP8 CASP5 CASP4 CASP3 CASP1
2 peptidase activity GO:0008233 9.91 CASP1 CASP3 CASP4 CASP5 CASP8 GZMB
3 coreceptor activity GO:0015026 9.88 CD8A CD86 CD80
4 cysteine-type peptidase activity GO:0008234 9.87 CASP8 CASP5 CASP4 CASP3 CASP1
5 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.7 CASP8 CASP5 CASP4 CASP3 CASP1
6 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.5 CASP8 CASP5 CASP4 CASP3 CASP1
7 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.32 CASP8 CASP5 CASP4 CASP3 CASP1

Sources for Cowpox

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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