Cowpox disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A viral infectious disease that results in infection in rodents, cows, and humans, located in skin, has material basis in Cowpox virus, which is transmitted by contact with an infected animal. The infection results in formation of vesicopustular lesions on the hands or face.

MalaCards based summary: Cowpox, also known as yaba, is related to vaccinia and stomatitis. An important gene associated with Cowpox is CASP1 (Caspase 1), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. Affiliated tissues include skin, t cells and ovary, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Wikipedia: ⁷⁵ Cowpox is an infectious disease caused by the cowpox virus (CPXV). It presents with large blisters in... more...

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Related Diseases for Cowpox

Diseases related to Cowpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 291)

#	Related Disease	Score	Top Affiliating Genes
1	vaccinia	31.3	IL6 GZMB EIF2S1 CD80
2	stomatitis	30.7	MX1 IL6 CXCL8
3	viral infectious disease	30.3	TNFRSF1A MX1 KLRK1 IL6 GZMB FAS
4	lymphadenitis	30.2	IL6 FAS CXCL8 CASP3
5	yellow fever	30.1	IL6 EIF2S1 CXCL1 CASP3
6	cellulitis	30.1	IL6 CXCL8 CD8A
7	viral encephalitis	30.0	MX1 IL6 CD8A
8	bronchopneumonia	30.0	IL6 CXCL8 CD8A
9	keratitis, hereditary	30.0	IL6 CXCL8 CXCL1 CD8A
10	tularemia	29.9	IL6 CD8A CASP1
11	respiratory failure	29.9	IL6 CXCL8 CXCL1 CD8A
12	tonsillitis	29.8	IL6 CXCL8 CXCL1 CASP3
13	pneumonia	29.8	IL6 CXCL8 CXCL1 CD8A
14	dengue disease	29.8	IL6 CXCL8 CD8A
15	human cytomegalovirus infection	29.8	KLRK1 IL6 CD8A
16	tracheitis	29.8	IL6 CXCL8 CD8A
17	exanthem	29.7	IL6 CXCL8 CD8A
18	autoimmune disease	29.5	TNFRSF1A KLRK1 IL6 FAS CD86 CD80
19	osteogenic sarcoma	29.4	XIAP IL6 CASP8 CASP3
20	dermatitis, atopic	29.4	IL6 CXCL8 CD8A CD86
21	panniculitis	29.3	GZMB FAS CD8A CASP3
22	skin disease	28.4	TNFRSF1A MX1 IL6 GZMB CXCL8 CXCL1
23	human infection by orthopoxvirus	11.0
24	smallpox	10.8
25	monkeypox	10.5
26	acute generalized exanthematous pustulosis	10.3	MX1 CXCL8
27	goat milk allergy	10.3	CD86 CD80
28	acute pericementitis	10.3	IL6 CXCL8
29	fuchs' heterochromic uveitis	10.3	IL6 CXCL8
30	necrotizing ulcerative gingivitis	10.3	IL6 CXCL8
31	adult-onset still's disease	10.3	IL6 IL18BP CASP1
32	paracoccidioidomycosis	10.3	IL6 CXCL8 CD86
33	acute cystitis	10.2	IL6 CXCL8 CXCL1
34	cystitis	10.2	IL6 CXCL8 CXCL1
35	bacteriuria	10.2	IL6 CXCL8 CXCL1
36	fibroma	10.2
37	brucellosis	10.2	IL6 CXCL8 CD86
38	bronchiolitis obliterans	10.2	IL6 CXCL8 CD80
39	chlamydia	10.2	IL6 CXCL8 CASP1
40	osteomyelitis	10.2	IL6 CXCL8 CASP1
41	endometritis	10.2	IL6 CXCL8 CXCL1
42	peptic ulcer disease	10.2	IL6 CXCL8 CXCL1
43	urethral syndrome	10.2	IL6 CXCL8 CXCL1
44	periodic fever, familial, autosomal dominant	10.2	TNFRSF1A IL6 CASP1
45	encephalomalacia	10.2	IL6 CXCL8 CASP3
46	periventricular leukomalacia	10.2	IL6 CXCL8 CASP3
47	duodenal ulcer	10.2	IL6 CXCL8 CXCL1
48	lymphocytic choriomeningitis	10.2	IL6 CXCL8 CD86 CD80
49	proteasome-associated autoinflammatory syndrome 1	10.2	IL6 CXCL8 CXCL1
50	muckle-wells syndrome	10.2	TNFRSF1A CXCL8 CASP1

Graphical network of the top 20 diseases related to Cowpox:

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Symptoms & Phenotypes for Cowpox

GenomeRNAi Phenotypes related to Cowpox according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	10.21	CASP3 CXCL8 EIF2S1 FAS GZMB TNFRSF1A
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	10.21	CASP1 CASP3 CASP4 CASP5 CXCL8 EIF2S1
3	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-3	10.21	CASP8
4	no effect	GR00402-S-1	10.15	CASP1 CASP3 CASP4 CASP5 CASP8 CD80
5	no effect	GR00402-S-2	10.15	CASP1 CASP3 CASP4 CASP5 CASP8 CD86

MGI Mouse Phenotypes related to Cowpox:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.36	CASP1 CASP3 CASP4 CASP5 CASP8 CD86
2	nervous system	MP:0003631	10.32	CASP1 CASP3 CASP4 CASP5 CASP8 CD80
3	endocrine/exocrine gland	MP:0005379	10.28	CASP1 CASP3 CASP4 CASP5 CASP8 CD80
4	immune system	MP:0005387	10.23	CASP1 CASP3 CASP4 CASP5 CASP8 CD80
5	cellular	MP:0005384	10.21	CASP1 CASP3 CASP4 CASP5 CASP8 CD80
6	renal/urinary system	MP:0005367	10.19	CASP1 CASP3 CASP4 CASP5 CASP8 CD8A
7	neoplasm	MP:0002006	10.18	CASP1 CASP4 CASP5 CASP8 FAS GZMB
8	hematopoietic system	MP:0005397	10.13	CASP1 CASP3 CASP4 CASP5 CASP8 CD80
9	cardiovascular system	MP:0005385	10.1	CASP1 CASP3 CASP4 CASP5 CASP8 CXCL1
10	muscle	MP:0005369	10.08	CASP3 CASP8 CD86 FAS IL6 TNFRSF1A
11	digestive/alimentary	MP:0005381	10.01	CASP1 CASP3 CASP4 CASP5 FAS IL6
12	mortality/aging	MP:0010768	9.83	CASP1 CASP3 CASP4 CASP5 CASP8 CD8A
13	integument	MP:0010771	9.4	CASP1 CASP3 CASP4 CASP5 CASP8 CD8A

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Drugs & Therapeutics for Cowpox

Search Clinical Trials, NIH Clinical Center for Cowpox

Cochrane evidence based reviews: cowpox

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Genetic Tests for Cowpox

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Anatomical Context for Cowpox

Organs/tissues related to Cowpox:

FMA: Skin

MalaCards : Skin, T Cells, Ovary, Kidney, Adrenal Cortex, Monocytes, B Cells

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Publications for Cowpox

Articles related to Cowpox:

(show top 50) (show all 1265)

#	Title	Authors	PMID	Year
1	Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation. ⁵³ ⁶²	Cathelin S...Solary E	16636047	2006
2	Alkylphosphocholine-induced glioma cell death is BCL-X(L)-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation. ⁵³ ⁶²	Naumann U...Weller M	15389288	2004
3	Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells. ⁵³ ⁶²	Izeradjene K...Houghton JA	15475455	2004
4	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL. ⁵³ ⁶²	Dai Y...Grant S	14645670	2003
5	Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins. ⁵³ ⁶²	Rodriguez JA...Giaccone G	12667137	2003
6	CrmE, a novel soluble tumor necrosis factor receptor encoded by poxviruses. ⁵³ ⁶²	Saraiva M...Alcami A	11119592	2001
7	Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins. ⁵³ ⁶²	Smith VP...Alcami A	10769064	2000
8	Hepatitis C virus core protein does not inhibit apoptosis in human hepatoma cells. ⁵³ ⁶²	Dumoulin FL...Spengler U	10583438	1999
9	Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates. ⁵³ ⁶²	Hansen H...Traavik T	10440063	1999
10	Uncouplers of oxidative phosphorylation can enhance a Fas death signal. ⁵³ ⁶²	Linsinger G...Hacker G	10207055	1999
11	Inhibition of human caspases by peptide-based and macromolecular inhibitors. ⁵³ ⁶²	Garcia-Calvo M...Thornberry NA	9829999	1998
12	A third distinct tumor necrosis factor receptor of orthopoxviruses. ⁵³ ⁶²	Loparev VN...Esposito JJ	9520445	1998
13	Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases. ⁵³ ⁶²	Kamada S...Tsujimoto Y	16465268	1997
14	Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. ⁵³ ⁶²	Villunger A...Greil R	9269989	1997
15	Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. ⁵³ ⁶²	Wissing D...Jaattela M	9144192	1997
16	Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. ⁵³ ⁶²	Juo P...Blenis J	8972182	1997
17	Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA. ⁵³ ⁶²	Marsters SA...Ashkenazi A	8793301	1996
18	Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. ⁵³ ⁶²	Howard AD...Tocci MJ	7868902	1995
19	Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. ⁵³ ⁶²	Komiyama T...Salvesen G	8034697	1994
20	Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses. ⁶²	Nikitina PA...Tikhonov AY	36414175	2023
21	Orthopoxvirus Seroprevalence and Infection Susceptibility in France, Bolivia, Laos, and Mali. ⁶²	Luciani L...de Lamballerie X	36343384	2022
22	Monkeypox as an emerging infectious disease: the ophthalmic implications. ⁶²	Milligan AL...Dunning J	36216412	2022
23	Necrotic facial ulceration caused by cowpox virus. ⁶²	Heer RS...Jones N	36458564	2022
24	Line-field confocal optical coherence tomography imaging of human cowpox virus skin infection. ⁶²	Cortonesi G...Cinotti E	35855673	2022
25	William chambers: British army surgeon (Toulon, 1793) and his vaccination institution (1803) in Brighton, England. ⁶²	Cooper MJ...Whiston B	33641509	2022
26	Monkeypox. ⁶²	Mitja O...Orkin CM	36403582	2022
27	Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. ⁶²	Brown LE...Connor JH	36222522	2022
28	Evaluation of Rapid Dot-Immunoassay for Detection Orthopoxviruses Using Laboratory-Grown Viruses and Animal's Clinical Specimens. ⁶²	Ushkalenko N...Poltavchenko A	36423189	2022
29	The effective factors in human-specific tropism and viral pathogenicity in orthopoxviruses. ⁶²	Ghabeshi S...Mousavizadeh L	36317465	2022
30	Multiple mechanisms for overcoming lethal over-initiation of DNA replication. ⁶²	Anderson ME...Grossman AD	36053906	2022
31	[Determination of the optimal immunizing dose of heterologous goat pox virus vaccine (Poxviridae: Chordopoxvirinae: Capripoxvirus) against lumpy skin disease]. ⁶²	Abitaev RT...Bulatov YA	36097711	2022
32	Enhancement of live vaccines by co-delivery of immune modulating proteins. ⁶²	Manohar MM...Moore RJ	36064671	2022
33	Genomic Sequencing and Phylogenomics of Cowpox Virus. ⁶²	Diaz-Canova D...Okeke MI	36298689	2022
34	The secreted protein Cowpox Virus 14 contributes to viral virulence and immune evasion by engaging Fc-gamma-receptors. ⁶²	Iyer RF...Fruh K	36121874	2022
35	Monkeypox, a Literature Review: What Is New and Where Does This concerning Virus Come From? ⁶²	Tiecco G...Quiros-Roldan E	36146705	2022
36	The presumed receptivity and susceptibility to monkeypox of European animal species. ⁶²	Haddad N	35753629	2022
37	Monkeypox: The Re-emerging Terror. ⁶²	Sapkal A...Agrawal S	36185856	2022
38	Genetic ancestry and population structure of vaccinia virus. ⁶²	Molteni C...Sironi M	35953491	2022
39	Genome stability of the vaccine strain VACΔ6. ⁶²	Maksyutov RA...Shchelkunov SN	35903306	2022
40	Design, Synthesis, and Biological Evaluation of (+)-Camphor- and (-)-Fenchone-Based Derivatives as Potent Orthopoxvirus Inhibitors. ⁶²	Sokolova AS...Salakhutdinov NF	35388614	2022
41	A Belgian student with black eschars. ⁶²	Van Reempts A...Huis In 't Veld D	35731612	2022
42	Structure and kinase activity of bacterial cell cycle regulator CcrZ. ⁶²	Wozniak KJ...Simmons LA	35576203	2022
43	Dr. James Smith's Dream of Eradicating Smallpox and the National Vaccine Institution. ⁶²	Lee HJ	35577219	2022
44	Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance. ⁶²	Andrei G...Snoeck R	35327382	2022
45	Life and death of smallpox. ⁶²	Berche P	35143880	2022
46	Transmission dynamics of Monkeypox virus: a mathematical modelling approach. ⁶²	Peter OJ...Musa R	34667829	2022
47	Molecular mimicry of NF-κB by vaccinia virus protein enables selective inhibition of antiviral responses. ⁶²	Albarnaz JD...Smith GL	34949827	2022
48	Genomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus. ⁶²	Diaz-Canova D...Okeke MI	35592007	2022
49	The Disease Ecology, Epidemiology, Clinical Manifestations, Management, Prevention, and Control of Increasing Human Infections with Animal Orthopoxviruses. ⁶²	Diaz JH	34563454	2021
50	Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity. ⁶²	Shiryaev VA...Klimochkin YN	33965861	2021

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Genes for Cowpox

Genes related to Cowpox (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CASP1	Caspase 1	Protein Coding	29.93	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Functions (show sections)	8034697 16465268 8972182 (more) 9829999 7868902
2	CASP8	Caspase 8	Protein Coding	18.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Proteins (show sections)	12667137 9829999 10207055 (more) 16636047 14645670
3	IL18BP	Interleukin 18 Binding Protein	Protein Coding	18.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10769064
4	CASP5	Caspase 5	Protein Coding	12.58	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16465268
5	KLRK1	Killer Cell Lectin Like Receptor K1	Protein Coding	12.22	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	CD86	CD86 Molecule	Protein Coding	11.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	CD80	CD80 Molecule	Protein Coding	11.7	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	IL6	Interleukin 6	Protein Coding	11.42	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	11.08	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	10.94	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	MX1	MX Dynamin Like GTPase 1	Protein Coding	10.92	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	ZMPSTE24	Zinc Metallopeptidase STE24	Protein Coding	10.64	DISEASES inferred ¹⁴ GeneCards inferred via : Functions (show sections)
13	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	10.18	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	CASP3	Caspase 3	Protein Coding	9.54	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16465268 9144192
15	FAS	Fas Cell Surface Death Receptor	Protein Coding	9.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8972182 9269989 10583438
16	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	8.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9520445 11119592
17	GZMB	Granzyme B	Protein Coding	8.14	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12667137
18	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	7.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15389288
19	CASP4	Caspase 4	Protein Coding	6.96	Novoseek inferred ⁵³	16465268
20	CD8A	CD8a Molecule	Protein Coding	5.93	DISEASES inferred ¹⁴
21	KLHL2	Kelch Like Family Member 2	Protein Coding	5.9	DISEASES inferred ¹⁴
22	CD4	CD4 Molecule	Protein Coding	5.68	DISEASES inferred ¹⁴

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Variations for Cowpox

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Expression for Cowpox

Search GEO for disease gene expression data for Cowpox.

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Pathways for Cowpox

Pathways related to Cowpox according to GeneCards Suite gene sharing:

(show top 50) (show all 65)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.93	TNFRSF1A MX1 KLRK1 IL6 IL18BP CXCL8
2	Apoptotic Pathways in Synovial Fibroblasts ⁶⁴ Show member pathways Actin-Based Motility by Rho Family GTPases ⁶⁴ Cellular Apoptosis Pathway ⁶⁴ DHA Signaling ⁶⁴ eIF2 Pathway ⁶⁴ ERK5 Signaling ⁶⁴ Glioma Invasiveness ⁶⁴ Mitochondrial Apoptosis ⁶⁴ Nuclear Receptor Activation by Vitamin-A ⁶⁴ p53 Mediated Apoptosis ⁶⁴ PPAR Pathway ⁶⁴ Rac1 Pathway ⁶⁴ Rap1 Pathway ⁶⁴ Telomerase Components in Cell Signaling ⁶⁴	13.86	CASP1 CASP3 CASP4 CASP5 CASP8 EIF2S1
3	Signal Transduction ⁶⁶	13.79	CASP3 CASP8 CD80 CD86 CXCL1 CXCL8
4	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.64	TNFRSF1A IL6 FAS CXCL8 CXCL1 CD80
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.43	CASP3 CD80 CXCL1 CXCL8 FAS IL6
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.25	CASP1 CASP3 CASP8 CD80 CD86 CXCL1
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.21	TNFRSF1A IL6 FAS CXCL8 CXCL1 CD80
8	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.92	XIAP TNFRSF1A GZMB FAS CASP8 CASP5
9	p75 NTR receptor-mediated signalling ⁶⁶ Show member pathways Axonal growth inhibition (RHOA activation) ⁶⁶ Axonal growth stimulation ⁶⁶ Cell death signalling via NRAGE, NRIF and NADE ⁶⁶ Death Receptor Signaling ⁶⁶ G alpha (12/13) signalling events ⁶⁶ NADE modulates death signalling ⁶⁶ NF-kB is activated and signals survival ⁶⁶ NRAGE signals death through JNK ⁶⁶ NRIF signals cell death from the nucleus ⁶⁶ p75NTR negatively regulates cell cycle via SC1 ⁶⁶ p75NTR recruits signalling complexes ⁶⁶ p75NTR regulates axonogenesis ⁶⁶ p75NTR signals via NF-kB ⁶⁶ Regulated proteolysis of p75NTR ⁶⁶	12.88	XIAP TNFRSF1A FAS CASP8 CASP3
10	Alzheimer's disease and miRNA effects ⁷⁴ Show member pathways Alzheimer's disease ⁷⁴	12.86	TNFRSF1A IL6 FAS EIF2S1 CASP8 CASP3
11	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways Arrhythmogenic right ventricular cardiomyopathy ⁷⁴ BMP Pathway ⁶⁴ Calpain Protease Regulates Cellular Mechanics ⁶⁴ Caspase Cascade ⁶⁴ nNOS Signaling in Skeletal Muscle ⁶⁴ Presynaptic depolarization and calcium channel opening ⁶⁶ TOB in Osteoblast Signaling ⁶⁴	12.8	TNFRSF1A GZMB FAS CASP8 CASP3 CASP1
12	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.75	CASP3 CASP8 CD80 CD86 CXCL8 EIF2S1
13	Programmed Cell Death ⁶⁶ Show member pathways Apoptosis ⁶⁶	12.65	XIAP GZMB FAS CASP8 CASP5 CASP4
14	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ TNFs bind their physiological receptors ⁶⁶ TRAF Pathway ⁶⁴	12.64	CASP1 CASP3 CASP4 CASP5 CASP8 FAS
15	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.63	MX1 IL6 CXCL8 CASP8 CASP3
16	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.53	XIAP CASP8 CASP5 CASP4 CASP3 CASP1
17	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.51	IL6 CXCL8 CASP5 CASP1
18	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.42	IL6 FAS CXCL8 CASP1
19	Death Receptor Signaling ⁶⁷ Show member pathways Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathway ⁶⁵ SARS-CoV-1-mediated effects on programmed cell death ⁶⁶ TNF Signaling ⁶⁷	12.4	XIAP TNFRSF1A FAS CASP8 CASP3
20	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.31	IL6 CXCL8 CXCL1 CASP8 CASP3
21	Intrinsic Pathway for Apoptosis ⁶⁶ Show member pathways Activation of BAD and translocation to mitochondria ⁶⁶ Activation of BH3-only proteins ⁶⁶ Activation of BIM and translocation to mitochondria ⁶⁶ Activation of BMF and translocation to mitochondria ⁶⁶ Activation of NOXA and translocation to mitochondria ⁶⁶ Activation of PUMA and translocation to mitochondria ⁶⁶ Activation, myristolyation of BID and translocation to mitochondria ⁶⁶ Apoptotic factor-mediated response ⁶⁶ BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members ⁶⁶ Cytochrome c-mediated apoptotic response ⁶⁶ Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function ⁶⁶ Release of apoptotic factors from the mitochondria ⁶⁶ SMAC, XIAP-regulated apoptotic response ⁶⁶	12.26	XIAP GZMB CASP8 CASP3
22	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	12.23	FAS CASP8 CASP5 CASP4 CASP3 CASP1
23	Apoptosis and survival FAS signaling cascades ²² Show member pathways Apoptosis and survival Caspase cascade ²² Breakdown of the nuclear lamina ⁶⁶ Caspase Cascade in Apoptosis ⁶¹ Fas ligand pathway and stress induction of heat shock proteins ⁷⁴ Fas Signaling ⁶⁴	12.22	XIAP TNFRSF1A GZMB FAS CASP8 CASP4
24	Presenilin-Mediated Signaling ⁶⁴	12.16	CASP8 CASP5 CASP4 CASP3 CASP1
25	Ceramide Pathway ⁶⁴ Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids ⁶⁴	12.06	CASP1 CASP3 CASP4 CASP5 CASP8 TNFRSF1A
26	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.05	KLRK1 IL6 CD8A CD86 CD80
27	Spinal cord injury ⁷⁴	12.03	IL6 CXCL8 CXCL1 CASP3
28	S-1P Stimulated Signaling ⁶⁴	12	CASP8 CASP5 CASP4 CASP3 CASP1
29	Senescence and autophagy in cancer ⁷⁴	11.93	IL6 CXCL8 CXCL1
30	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.91	IL6 CD86 CD80
31	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.91	CD80 CD86 GZMB IL6
32	CCL18 signaling pathway ⁷⁴	11.89	IL6 CXCL8 CASP8
33	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ⁶⁶ Show member pathways NOD1/2 Signaling Pathway ⁶⁶	11.88	CASP8 CASP4 CASP1
34	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.87	CXCL1 CXCL8 IL6
35	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.83	IL6 CXCL8 CD8A CASP3
36	Burn wound healing ⁷⁴	11.81	IL6 CXCL8 CXCL1 CASP3
37	Innate Lymphoid Cells Differentiation ⁶⁵	11.8	KLRK1 GZMB CD8A
38	RIPK1-mediated regulated necrosis ⁶⁶ Show member pathways Defective RIPK1-mediated regulated necrosis ⁶⁶ Microbial modulation of RIPK1-mediated regulated necrosis ⁶⁶ Pyroptosis ⁶⁶ Regulated Necrosis ⁶⁶ Regulation of necroptotic cell death ⁶⁶	11.77	XIAP GZMB FAS CASP8 CASP5 CASP4
39	Acute viral myocarditis ⁷⁴	11.76	CASP3 CD80 IL6
40	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.68	TNFRSF1A IL6 CXCL8
41	miRNAs involvement in the immune response in sepsis ⁷⁴	11.67	IL6 GZMB CXCL8
42	Allograft rejection ⁷⁴	11.67	CASP3 CASP8 CD80 CD86 CXCL8 FAS
43	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.63	MX1 CXCL8 CXCL1 CASP8
44	Apoptosis and Autophagy ³ Show member pathways Activation and oligomerization of BAK protein ⁶⁶ AIF Pathway ⁶⁴ Nanomaterial induced apoptosis ⁷⁴ Pro-survival signaling of neuroprotectin D1 ⁷⁴ vRNA Synthesis ⁶⁶	11.63	XIAP TNFRSF1A GZMB FAS CASP8 CASP5
45	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.62	IL6 CXCL8 CASP3
46	IL-18 signaling pathway ⁷⁴	11.61	CASP3 CASP8 FAS TNFRSF1A
47	Granzyme Pathway ⁶⁴ Show member pathways Granzyme-B Pathway ⁶⁴	11.6	CASP3 CASP8 GZMB
48	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.58	TNFRSF1A IL6 CXCL8
49	Nonalcoholic fatty liver disease ⁷⁴	11.54	TNFRSF1A IL6 FAS EIF2S1 CASP8
50	Nucleotide-binding oligomerization domain (NOD) pathway ⁷⁴	11.51	XIAP CASP8 CASP5 CASP1

Sources

GO Terms for Cowpox

Cellular components related to Cowpox according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	AIM2 inflammasome complex	GO:0097169	9.62	CASP4 CASP1
2	CD95 death-inducing signaling complex	GO:0031265	9.56	FAS CASP8
3	IPAF inflammasome complex	GO:0072557	9.46	CASP4 CASP1
4	NLRP1 inflammasome complex	GO:0072558	9.26	CASP5 CASP1
5	death-inducing signaling complex	GO:0031264	9.1	FAS CASP8 CASP3

Biological processes related to Cowpox according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	10.25	ZMPSTE24 GZMB CASP8 CASP5 CASP4 CASP3
2	immune response	GO:0006955	10.11	CD80 CD86 CD8A CXCL1 CXCL8 FAS
3	regulation of inflammatory response	GO:0050727	10.1	XIAP CASP5 CASP4 CASP1
4	regulation of apoptotic process	GO:0042981	10.06	XIAP FAS CASP8 CASP5 CASP4 CASP1
5	apoptotic signaling pathway	GO:0097190	10.01	CASP8 CASP5 CASP3 CASP1
6	T cell costimulation	GO:0031295	10	KLRK1 CD86 CD80
7	cellular response to mechanical stimulus	GO:0071260	9.96	TNFRSF1A FAS CASP8 CASP5 CASP1
8	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	9.93	CASP1 CASP4 CASP5 CASP8
9	defense response	GO:0006952	9.91	TNFRSF1A MX1 CXCL8 CXCL1
10	apoptotic process	GO:0006915	9.91	XIAP TNFRSF1A MX1 GZMB FAS CASP8
11	response to cobalt ion	GO:0032025	9.84	CASP8 CASP3
12	positive regulation of type B pancreatic cell apoptotic process	GO:2000676	9.78	IL6 EIF2S1
13	pyroptosis	GO:0070269	9.76	CASP1 CASP4 CASP8 GZMB
14	cellular response to lipopolysaccharide	GO:0071222	9.47	KLRK1 IL6 CXCL8 CXCL1 CD86 CD80

Molecular functions related to Cowpox according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cysteine-type endopeptidase activity	GO:0004197	10.07	CASP8 CASP5 CASP4 CASP3 CASP1
2	peptidase activity	GO:0008233	9.91	CASP1 CASP3 CASP4 CASP5 CASP8 GZMB
3	coreceptor activity	GO:0015026	9.88	CD8A CD86 CD80
4	cysteine-type peptidase activity	GO:0008234	9.87	CASP8 CASP5 CASP4 CASP3 CASP1
5	cysteine-type endopeptidase activity involved in apoptotic process	GO:0097153	9.7	CASP8 CASP5 CASP4 CASP3 CASP1
6	cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO:0097200	9.5	CASP8 CASP5 CASP4 CASP3 CASP1
7	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO:0097199	9.32	CASP8 CASP5 CASP4 CASP3 CASP1

Sources

Sources for Cowpox

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

YABA MCID: CWP001 MIFTS: 43	Cowpox (YABA) Categories: Infectious diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Expand all tables

Cowpox (YABA)

Aliases & Classifications for Cowpox

MalaCards integrated aliases for Cowpox:

Classifications:

External Ids:

Summaries for Cowpox

Related Diseases for Cowpox

Diseases related to Cowpox via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Cowpox:

Symptoms & Phenotypes for Cowpox

GenomeRNAi Phenotypes related to Cowpox according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Cowpox:

Drugs & Therapeutics for Cowpox

Cochrane evidence based reviews: cowpox

Genetic Tests for Cowpox

Anatomical Context for Cowpox

Organs/tissues related to Cowpox:

Publications for Cowpox

Articles related to Cowpox:

Genes for Cowpox

Genes related to Cowpox (0 elite genes):

Variations for Cowpox

Expression for Cowpox

Pathways for Cowpox

Pathways related to Cowpox according to GeneCards Suite gene sharing:

GO Terms for Cowpox

Cellular components related to Cowpox according to GeneCards Suite gene sharing:

Biological processes related to Cowpox according to GeneCards Suite gene sharing:

Molecular functions related to Cowpox according to GeneCards Suite gene sharing:

Sources for Cowpox