YABA
MCID: CWP001
MIFTS: 45

Cowpox (YABA)

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Cowpox

MalaCards integrated aliases for Cowpox:

Name: Cowpox 12 74 54 43 15 17 71
Yaba 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8956
ICD9CM 34 051.01
MeSH 43 D015605
SNOMED-CT 67 70090004
ICD10 32 B08.010
UMLS 71 C0010232

Summaries for Cowpox

Disease Ontology : 12 A viral infectious disease that results in infection in rodents, cows, and humans, located in skin, has material basis in Cowpox virus, which is transmitted by contact with an infected animal. The infection results in formation of vesicopustular lesions on the hands or face.

MalaCards based summary : Cowpox, also known as yaba, is related to variola major and monkeypox. An important gene associated with Cowpox is CASP1 (Caspase 1), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Vaccines and Rho(D) Immune Globulin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Cowpox is an infectious disease caused by the cowpox virus. The virus, part of the genus Orthopoxvirus,... more...

Related Diseases for Cowpox

Diseases related to Cowpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 variola major 31.3 KLHL2 CD8A
2 monkeypox 30.8 PRODH KLHL2 CD8A
3 lymphadenitis 30.7 FAS CXCL8 CASP3
4 bronchopneumonia 30.5 IL6 CXCL8 CD8A
5 tularemia 30.5 IL6 CD8A CASP1
6 yellow fever 30.3 IL6 CXCL1 CD8A CASP3
7 variola minor 30.3 PRODH KLHL2
8 pneumonia 30.3 IL6 CXCL8 CXCL1 CD8A
9 keratitis, hereditary 30.3 IL6 CXCL8 CXCL1 CD8A
10 tonsillitis 30.3 IL6 CXCL8 CXCL1 CASP3
11 exanthem 30.2 IL6 CXCL8 CD8A
12 cytomegalovirus infection 30.2 IL6 FAS CXCL8 CASP3
13 stomatitis 30.2 MX1 IL6 CXCL8
14 panniculitis 30.1 GZMB FAS CD8A
15 viral infectious disease 29.6 MX1 KLRK1 IL6 GZMB FAS EIF2S1
16 skin disease 29.3 PRODH MX1 IL6 CXCL8 CD8A CASP8
17 bacterial infectious disease 29.3 PRODH MX1 IL6 CXCL8 CD8A CASP1
18 obsolete: cowpox infection 12.2
19 vaccinia 11.0
20 smallpox 10.9
21 obsolete: small pox 10.7
22 idiopathic anterior uveitis 10.5 IL6 CXCL8
23 streptococcal toxic-shock syndrome 10.5 IL6 CXCL8
24 acute transverse myelitis 10.5 IL6 CXCL8
25 pneumococcal meningitis 10.5 CASP3 CASP1
26 acute generalized exanthematous pustulosis 10.5 MX1 CXCL8
27 tendinopathy 10.5 CASP8 CASP3
28 fuchs' heterochromic uveitis 10.5 IL6 CXCL8
29 indolent myeloma 10.5 IL6 CASP1
30 esophagus melanoma 10.5 FAS CXCL8
31 bacteriuria 10.4 IL6 CXCL8 CXCL1
32 endometritis 10.4 IL6 CXCL8 CXCL1
33 post-transplant lymphoproliferative disease 10.4 TNFRSF1A IL6 CASP8
34 fibroma 10.4
35 acute cystitis 10.4 IL6 CXCL8 CXCL1
36 avian influenza 10.4 IL6 CXCL8 CASP8
37 spinal cord injury 10.4 IL6 CXCL8 CASP3
38 dengue hemorrhagic fever 10.4 MX1 IL6 CXCL8
39 crimean-congo hemorrhagic fever 10.4 MX1 IL6 CASP3
40 periodic fever, familial, autosomal dominant 10.4 TNFRSF1A IL6 CASP1
41 bone sarcoma 10.4 TNFRSF1A IL6 CXCL8
42 muckle-wells syndrome 10.4 TNFRSF1A CXCL8 CASP1
43 severe acute respiratory syndrome 10.4 MX1 IL6 CXCL8
44 chlamydia 10.4 IL6 CXCL8 CASP1
45 cinca syndrome 10.3 TNFRSF1A IL6 CASP1
46 helicobacter pylori infection 10.3 CXCL8 CXCL1 CASP3
47 silicosis 10.3 FAS CXCL8 CASP1
48 dystrophinopathies 10.3 TNFRSF1A CASP8
49 myelitis 10.3 TNFRSF1A IL6 CXCL8
50 bacterial meningitis 10.3 IL6 CXCL8 CXCL1

Graphical network of the top 20 diseases related to Cowpox:



Diseases related to Cowpox

Symptoms & Phenotypes for Cowpox

GenomeRNAi Phenotypes related to Cowpox according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10 CASP1 CASP3 CASP4 CASP5 CASP8 CXCL8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10 CASP1 CASP3 CASP4 CASP5 CASP8 CXCL8

MGI Mouse Phenotypes related to Cowpox:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10 CASP1 CASP3 CASP4 CASP8 CD8A EIF2S1
2 hematopoietic system MP:0005397 9.9 CASP1 CASP3 CASP4 CASP8 CD8A EIF2S1
3 integument MP:0010771 9.65 CASP1 CASP3 CASP4 CASP8 CD8A FAS
4 renal/urinary system MP:0005367 9.28 CASP1 CASP3 CASP4 CASP8 CD8A FAS

Drugs & Therapeutics for Cowpox

Drugs for Cowpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Rho(D) Immune Globulin Phase 2
3 Immunoglobulins, Intravenous Phase 2
4 gamma-Globulins Phase 2
5 Immunoglobulin G Phase 2
6 Horseradish Tree
7 Antibodies Early Phase 1
8 Immunoglobulins Early Phase 1
9 Immunologic Factors Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation and Treatment of Ocular Complications of Vaccinia Vaccination: Suitability of NP-016 Vaccinia Immune Globulin (VIG) for Sight-Threatening Conditions [VIG31] Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
2 Effect of Moringa Oleifera on Bone Density in Post-Menopausal Women Completed NCT03026660
3 Innovative Tools to Expand HIV Self-Testing Enrolling by invitation NCT04070287 Early Phase 1

Search NIH Clinical Center for Cowpox

Cochrane evidence based reviews: cowpox

Genetic Tests for Cowpox

Anatomical Context for Cowpox

The Foundational Model of Anatomy Ontology organs/tissues related to Cowpox:

19
Skin

MalaCards organs/tissues related to Cowpox:

40
Skin, T Cells, Bone, Liver, Testes, Kidney, Ovary

Publications for Cowpox

Articles related to Cowpox:

(show top 50) (show all 1198)
# Title Authors PMID Year
1
Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation. 54 61
16636047 2006
2
Alkylphosphocholine-induced glioma cell death is BCL-X(L)-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation. 54 61
15389288 2004
3
Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells. 54 61
15475455 2004
4
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL. 54 61
14645670 2003
5
Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins. 54 61
12667137 2003
6
CrmE, a novel soluble tumor necrosis factor receptor encoded by poxviruses. 54 61
11119592 2001
7
Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins. 54 61
10769064 2000
8
Hepatitis C virus core protein does not inhibit apoptosis in human hepatoma cells. 54 61
10583438 1999
9
Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates. 54 61
10440063 1999
10
Uncouplers of oxidative phosphorylation can enhance a Fas death signal. 54 61
10207055 1999
11
Inhibition of human caspases by peptide-based and macromolecular inhibitors. 54 61
9829999 1998
12
A third distinct tumor necrosis factor receptor of orthopoxviruses. 54 61
9520445 1998
13
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases. 54 61
16465268 1997
14
Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. 54 61
9269989 1997
15
Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. 54 61
9144192 1997
16
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. 54 61
8972182 1997
17
Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA. 54 61
8793301 1996
18
Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 54 61
7868902 1995
19
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 54 61
8034697 1994
20
Patchy Occurrence of Cowpox Virus in Voles from Germany. 61
32013767 2020
21
Antibiotics: From the Beginning to the Future: Part 1. 61
31713213 2020
22
What a Difference a Gene Makes: Identification of Virulence Factors of Cowpox Virus. 61
31645446 2020
23
Common vole (Microtus arvalis) and bank vole (Myodes glareolus) derived permanent cell lines differ in their susceptibility and replication kinetics of animal and zoonotic viruses. 61
31513859 2019
24
Molecular Detection and Characterization of the First Cowpox Virus Isolate Derived from a Bank Vole. 61
31752129 2019
25
Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation. 61
31575740 2019
26
Sir Matthew Tierney and the foundation of the 1804 Sussex Vaccine Institution. 61
31566102 2019
27
[Facial necrosis caused by orthopoxvirus : Differential diagnosis and dermatohistopathological correlation of infectious facial ulcers]. 61
31076814 2019
28
Zoonotic Virus Seroprevalence among Bank Voles, Poland, 2002-2010. 61
31310209 2019
29
A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection. 61
30996093 2019
30
Identification of CP77 as the Third Orthopoxvirus SAMD9 and SAMD9L Inhibitor with Unique Specificity for a Rodent SAMD9L. 61
30918078 2019
31
[Human poxvirus infections]. 61
31079914 2019
32
Polyglutamine Repeats in Viruses. 61
30182336 2019
33
CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants. 61
30992316 2019
34
RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals. 61
30883607 2019
35
Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor. 61
30578797 2019
36
Atypical Cowpox Virus Infection in Smallpox-Vaccinated Patient, France. 61
30666929 2019
37
Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals. 61
31240676 2019
38
Recombinant Poxviruses: Versatile Tools for Immunological Assays. 61
31147943 2019
39
Cowpox virus infection in two brothers with possible human-to-human transmission. 61
29852532 2019
40
Use of Next Generation Sequencing to study two cowpox virus outbreaks. 61
30847261 2019
41
A System Based-Approach to Examine Cytokine Response in Poxvirus-Infected Macrophages. 61
30563103 2018
42
A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox-, adeno-, and herpesviruses. 61
30287226 2018
43
Whole Genome Characterization of Orthopoxvirus (OPV) Abatino, a Zoonotic Virus Representing a Putative Novel Clade of Old World Orthopoxviruses. 61
30301229 2018
44
Synthesis and antiviral activity of camphor-based 1,3-thiazolidin-4-one and thiazole derivatives as Orthopoxvirus-reproduction inhibitors. 61
30429979 2018
45
Air Pollution Monitoring Around Residential and Transportation Sector Locations in Lagos Mainland. 61
30524862 2018
46
Novel Orthopoxvirus and Lethal Disease in Cat, Italy. 61
30124195 2018
47
Trends in the use of illicit substances in Thailand: Results from national household surveys. 61
29488268 2018
48
Edward Jenner's 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox. 61
29978749 2018
49
Bayesian reconstruction of the evolutionary history and cross-species transition of variola virus and orthopoxviruses. 61
29446492 2018
50
Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol. 61
29676720 2018

Variations for Cowpox

Expression for Cowpox

Search GEO for disease gene expression data for Cowpox.

Pathways for Cowpox

Pathways related to Cowpox according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 TNFRSF1A MX1 KLRK1 KLHL2 IL6 IL18BP
2
Show member pathways
13.86 XIAP TNFRSF1A IL6 FAS EIF2S1 CASP8
3
Show member pathways
13.7 TNFRSF1A IL6 FAS CXCL8 CXCL1 CASP8
4
Show member pathways
13.58 TNFRSF1A IL6 GZMB FAS EIF2S1 CXCL8
5
Show member pathways
13.38 TNFRSF1A MX1 IL6 IL18BP CXCL8 CXCL1
6
Show member pathways
13.29 TNFRSF1A IL6 FAS CXCL8 CXCL1 CASP8
7
Show member pathways
13.07 TNFRSF1A MX1 IL6 FAS EIF2S1 CXCL8
8
Show member pathways
13.01 TNFRSF1A MX1 IL6 FAS CASP8 CASP3
9
Show member pathways
12.95 TNFRSF1A IL6 FAS CXCL8 CXCL1 CASP8
10
Show member pathways
12.93 XIAP TNFRSF1A IL6 FAS CASP8 CASP5
11
Show member pathways
12.88 IL6 GZMB FAS CXCL8 CD8A CASP8
12 12.87 XIAP IL6 FAS CXCL8 CASP8 CASP3
13 12.82 TNFRSF1A IL6 FAS EIF2S1 CASP8 CASP3
14 12.78 TNFRSF1A FAS CASP8 CASP3 CASP1
15
Show member pathways
12.76 TNFRSF1A MX1 IL6 FAS EIF2S1 CXCL8
16
Show member pathways
12.72 XIAP TNFRSF1A GZMB FAS EIF2S1 CASP8
17
Show member pathways
12.71 XIAP FAS CASP8 CASP3 CASP1
18
Show member pathways
12.7 TNFRSF1A GZMB FAS CASP8 CASP3 CASP1
19
Show member pathways
12.59 TNFRSF1A FAS CASP8 CASP5 CASP4 CASP3
20
Show member pathways
12.53 XIAP CASP8 CASP5 CASP4 CASP3 CASP1
21 12.39 TNFRSF1A CXCL8 CASP4 CASP1
22
Show member pathways
12.37 IL6 CXCL8 CXCL1 CASP8 CASP3
23
Show member pathways
12.35 TNFRSF1A IL6 CXCL8 CXCL1
24
Show member pathways
12.35 XIAP TNFRSF1A FAS CASP8
25
Show member pathways
12.31 XIAP FAS CASP8 CASP3
26
Show member pathways
12.3 FAS CASP8 CASP5 CASP4 CASP3 CASP1
27
Show member pathways
12.28 XIAP TNFRSF1A CASP8 CASP3
28 12.25 TNFRSF1A IL6 CASP8 CASP3
29
Show member pathways
12.24 XIAP TNFRSF1A FAS CASP8 CASP1
30 12.16 TNFRSF1A IL6 FAS CXCL8 CASP8 CASP4
31 12.13 CASP8 CASP5 CASP4 CASP3 CASP1
32
Show member pathways
12.06 XIAP GZMB CASP8 CASP3
33 12.04 IL6 CXCL8 CXCL1 CASP3
34
Show member pathways
12.04 TNFRSF1A CASP8 CASP5 CASP4 CASP3 CASP1
35 12.02 XIAP IL6 CXCL8 CXCL1 CASP8 CASP5
36 11.98 CASP8 CASP5 CASP4 CASP3 CASP1
37 11.98 TNFRSF1A IL6 FAS CXCL1 CASP8 CASP3
38 11.96 XIAP TNFRSF1A CXCL8 CXCL1
39 11.96 IL6 CXCL8 CXCL1 CASP3
40 11.87 IL6 CXCL8 CXCL1
41
Show member pathways
11.87 IL6 CXCL8 CXCL1
42
Show member pathways
11.85 XIAP TNFRSF1A FAS CASP8 CASP3
43 11.84 IL6 CXCL8 CXCL1 CASP1
44
Show member pathways
11.82 XIAP TNFRSF1A GZMB FAS CASP8 CASP4
45 11.8 KLRK1 GZMB CD8A
46 11.8 IL6 CXCL8 CASP3 CASP1
47 11.78 XIAP FAS CASP8 CASP3
48 11.7 IL6 CXCL8 CASP3
49
Show member pathways
11.68 TNFRSF1A IL6 CXCL8
50 11.58 TNFRSF1A IL6 FAS

GO Terms for Cowpox

Cellular components related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.71 TNFRSF1A FAS CASP8 CASP3
2 NLRP3 inflammasome complex GO:0072559 9.37 CASP4 CASP1
3 CD95 death-inducing signaling complex GO:0031265 9.32 FAS CASP8
4 AIM2 inflammasome complex GO:0097169 9.26 CASP4 CASP1
5 NLRP1 inflammasome complex GO:0072558 9.16 CASP5 CASP1
6 IPAF inflammasome complex GO:0072557 8.96 CASP4 CASP1
7 death-inducing signaling complex GO:0031264 8.8 FAS CASP8 CASP3

Biological processes related to Cowpox according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 GZMB CASP8 CASP5 CASP4 CASP3 CASP1
2 immune response GO:0006955 9.96 IL6 FAS CXCL8 CXCL1 CD8A
3 inflammatory response GO:0006954 9.92 TNFRSF1A IL6 CXCL8 CXCL1 CASP4
4 regulation of apoptotic process GO:0042981 9.83 FAS CASP8 CASP5 CASP4 CASP1
5 cytokine-mediated signaling pathway GO:0019221 9.8 TNFRSF1A IL6 CXCL8 CXCL1 CASP3 CASP1
6 defense response GO:0006952 9.78 TNFRSF1A MX1 CXCL8 CXCL1
7 cellular response to lipopolysaccharide GO:0071222 9.77 KLRK1 IL6 CXCL8 CXCL1 CASP1
8 regulation of inflammatory response GO:0050727 9.71 XIAP CASP5 CASP4 CASP1
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.65 FAS CASP8 CASP5 CASP4 CASP1
10 PERK-mediated unfolded protein response GO:0036499 9.57 EIF2S1 CXCL8
11 positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265 9.55 CASP4 CASP1
12 cellular response to mechanical stimulus GO:0071260 9.55 TNFRSF1A FAS CASP8 CASP5 CASP1
13 death-inducing signaling complex assembly GO:0071550 9.54 TNFRSF1A CASP8
14 response to cobalt ion GO:0032025 9.51 CASP8 CASP3
15 positive regulation of type B pancreatic cell apoptotic process GO:2000676 9.46 IL6 EIF2S1
16 apoptotic signaling pathway GO:0097190 9.35 FAS CASP8 CASP5 CASP3 CASP1
17 apoptotic process GO:0006915 9.32 XIAP TNFRSF1A MX1 GZMB FAS CASP8

Molecular functions related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.8 GZMB CASP8 CASP5 CASP4 CASP3 CASP1
2 cysteine-type peptidase activity GO:0008234 9.65 CASP8 CASP5 CASP4 CASP3 CASP1
3 cysteine-type endopeptidase activity GO:0004197 9.55 CASP8 CASP5 CASP4 CASP3 CASP1
4 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.35 CASP8 CASP5 CASP4 CASP3 CASP1
5 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.02 CASP8 CASP5 CASP4 CASP3 CASP1

Sources for Cowpox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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