YABA
MCID: CWP001
MIFTS: 47

Cowpox (YABA)

Categories: Infectious diseases

Aliases & Classifications for Cowpox

MalaCards integrated aliases for Cowpox:

Name: Cowpox 12 77 56 45 15 17 74
Yaba 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8956
ICD9CM 36 051.01
MeSH 45 D015605
SNOMED-CT 69 70090004
ICD10 34 B08.010
UMLS 74 C0010232

Summaries for Cowpox

Disease Ontology : 12 A viral infectious disease that results in infection in rodents, cows, and humans, located in skin, has material basis in Cowpox virus, which is transmitted by contact with an infected animal. The infection results in_formation_of vesicopustular lesions on the hands or face.

MalaCards based summary : Cowpox, also known as yaba, is related to vaccinia and smallpox. An important gene associated with Cowpox is CASP1 (Caspase 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. The drugs Haloperidol and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Cowpox is an infectious disease caused by the cowpox virus. The virus, part of the genus Orthopoxvirus,... more...

Related Diseases for Cowpox

Diseases related to Cowpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 vaccinia 10.8
2 smallpox 10.5
3 monkeypox 10.4
4 cholestasis, benign recurrent intrahepatic, 2 10.3 CASP1 CASP8
5 israeli tick typhus 10.3 CASP1 CXCL8
6 recurrent corneal erosion 10.3 CXCL8 IL6
7 bagassosis 10.3 CXCL8 IL6
8 acute transverse myelitis 10.3 CXCL8 IL6
9 transverse myelitis 10.3 CXCL8 IL6
10 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6
11 denture stomatitis 10.2 CXCL8 IL6
12 papillary conjunctivitis 10.2 CXCL8 IL6
13 post-transplant lymphoproliferative disease 10.2 CASP8 IL6
14 funisitis 10.2 CXCL8 IL6
15 burn scar 10.2 CASP1 FAS
16 fibroma 10.2
17 acute monoblastic leukemia 10.2 CXCL8 IL6
18 capillary leak syndrome 10.2 CXCL8 IL6
19 meconium aspiration syndrome 10.2 CXCL8 IL6
20 louse-borne relapsing fever 10.2 CXCL8 IL6
21 endometrial disease 10.2 CXCL8 IL6
22 vaginal disease 10.2 CXCL8 IL6
23 vaginitis 10.2 CXCL8 IL6
24 pyelitis 10.2 CXCL8 IL6
25 necrotizing fasciitis 10.2 CXCL8 IL6
26 fasciitis 10.2 CXCL8 IL6
27 viral meningitis 10.2 CXCL8 IL6
28 radiculopathy 10.2 CXCL8 IL6
29 bacteriuria 10.2 CXCL8 IL6
30 encephalitis 10.2
31 pulpitis 10.2 CXCL8 IL6
32 acute cystitis 10.2 CXCL8 IL6
33 yellow fever 10.1
34 middle ear disease 10.1 CXCL8 IL6
35 acute pyelonephritis 10.1 CXCL8 IL6
36 lymphocytic gastritis 10.1 FAS GZMB
37 chlamydia 10.1 CASP1 CXCL8 IL6
38 primary effusion lymphoma 10.1 CASP3 IL6
39 lymphomatoid papulosis 10.1 FAS GZMB
40 bacterial infectious disease 10.1 CASP1 CXCL8 IL6
41 variola major 10.1
42 lymphadenitis 10.1
43 pneumonia 10.1
44 influenza 10.1
45 venezuelan equine encephalitis 10.1
46 perinatal necrotizing enterocolitis 10.1 CXCL8 IL6
47 nodular goiter 10.1 FAS IL6
48 kaposi sarcoma 10.1 CASP8 CXCL8 IL6
49 traumatic brain injury 10.0 CASP3 IL6
50 viral encephalitis 10.0 CXCL8 IL6

Graphical network of the top 20 diseases related to Cowpox:



Diseases related to Cowpox

Symptoms & Phenotypes for Cowpox

GenomeRNAi Phenotypes related to Cowpox according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS

MGI Mouse Phenotypes related to Cowpox:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 CASP1 CASP3 CASP8 FAS IL6 XIAP
2 integument MP:0010771 9.43 CASP1 CASP3 CASP8 FAS IL6 XIAP
3 renal/urinary system MP:0005367 9.02 CASP1 CASP3 CASP8 FAS IL6

Drugs & Therapeutics for Cowpox

Drugs for Cowpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Haloperidol Approved Phase 1, Phase 2 52-86-8 3559
2
Dopamine Approved Phase 1, Phase 2 62-31-7, 51-61-6 681
3 Dopamine Agents Phase 1, Phase 2
4 Central Nervous System Depressants Phase 1, Phase 2
5 Peripheral Nervous System Agents Phase 1, Phase 2
6 Autonomic Agents Phase 1, Phase 2
7 Psychotropic Drugs Phase 1, Phase 2
8 Neurotransmitter Agents Phase 1, Phase 2
9 Haloperidol decanoate Phase 1, Phase 2
10 Antipsychotic Agents Phase 1, Phase 2
11 Antiemetics Phase 1, Phase 2
12 Gastrointestinal Agents Phase 1, Phase 2
13 Dopamine Antagonists Phase 1, Phase 2
14 Tranquilizing Agents Phase 1, Phase 2
15 Immunologic Factors Phase 2
16 Antibodies Phase 2
17 Immunoglobulin G Phase 2
18 Immunoglobulins, Intravenous Phase 2
19 gamma-Globulins Phase 2
20 Vaccines Phase 2
21 Rho(D) Immune Globulin Phase 2
22 Immunoglobulins Phase 2
23 Anti-Retroviral Agents Not Applicable
24 Antiviral Agents Not Applicable
25 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antipsychotic Effects of Sorghum Bicolor (JOBELYN) in the Treatment of Schizophrenia Unknown status NCT02240173 Phase 1, Phase 2 Haloperidol
2 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
3 Acceptability and Performance of HIV Self-Testing in a Youth Population in Nigeria Active, not recruiting NCT03874663
4 The Effectiveness of SMS in Improving Antiretroviral Medication Adherence Among Adolescents Living With HIV in Nigeria Active, not recruiting NCT03394391 Not Applicable

Search NIH Clinical Center for Cowpox

Cochrane evidence based reviews: cowpox

Genetic Tests for Cowpox

Anatomical Context for Cowpox

The Foundational Model of Anatomy Ontology organs/tissues related to Cowpox:

20
Skin

MalaCards organs/tissues related to Cowpox:

42
Skin, Testes, Kidney, Eye, T Cells, Ovary, Monocytes

Publications for Cowpox

Articles related to Cowpox:

(show top 50) (show all 458)
# Title Authors Year
1
Atypical Cowpox Virus Infection in Smallpox-Vaccinated Patient, France. ( 30666929 )
2019
2
Use of Next Generation Sequencing to study two cowpox virus outbreaks. ( 30847261 )
2019
3
Edward Jenner's 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox. ( 29978749 )
2018
4
The Cowpox Controversy: Memory and the Politics of Public Health in Cuba. ( 29681552 )
2018
5
Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores. ( 29379051 )
2018
6
Cowpox Virus Infection. ( 29320650 )
2018
7
Atypical Cowpox Virus Infection in a Series of Cats. ( 29422319 )
2018
8
Cowpox virus infection in two brothers with possible human-to-human transmission. ( 29852532 )
2018
9
A Research Enclave in 1940s Nigeria: The Rockefeller Foundation Yellow Fever Research Institute at Yaba, Lagos, 1943-49. ( 29681554 )
2018
10
Phosphorylation of the Bacillus subtilis Replication Controller YabA Plays a Role in Regulation of Sporulation and Biofilm Formation. ( 29619013 )
2018
11
Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine. ( 29137821 )
2017
12
Novel characteristics identified in two cases of feline cowpox virus infection. ( 28839944 )
2017
13
Epidemiological Investigations of Four Cowpox Virus Outbreaks in Alpaca Herds, Germany. ( 29156539 )
2017
14
Generalised cowpox virus infection. ( 28669644 )
2017
15
Two Distinct Clinical Courses of Human Cowpox, Germany, 2015. ( 29215552 )
2017
16
Experimental Cowpox Virus (CPXV) Infections of Bank Voles: Exceptional Clinical Resistance and Variable Reservoir Competence. ( 29257111 )
2017
17
Seasonal recurrence of cowpox virus outbreaks in captive cheetahs (Acinonyx jubatus). ( 29121668 )
2017
18
Cowpox Virus: A New and Armed Oncolytic Poxvirus. ( 28951885 )
2017
19
Cowpox virus: What's in a Name? ( 28486428 )
2017
20
Vaccinia virus and Cowpox virus are not susceptible to the interferon-induced antiviral protein MxA. ( 28727764 )
2017
21
Classification of Cowpox Viruses into Several Distinct Clades and Identification of a Novel Lineage. ( 28604604 )
2017
22
Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells. ( 29363167 )
2017
23
Cowpox virus infection in a child after contact with a domestic cat: a case report. ( 28368077 )
2017
24
Histopathological and Immunohistochemical Studies of Cowpox Virus Replication in a Three-Dimensional Skin Model. ( 27291992 )
2016
25
Generalized Cowpox Virus Infection in a Patient with HIV, Germany, 2012. ( 26891134 )
2016
26
Fatal disseminated cowpox virus infection in an adolescent renal transplant recipient. ( 27796621 )
2016
27
Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease. ( 27166137 )
2016
28
Cowpox in a human, Russia, 2015. ( 27917750 )
2016
29
Fatal Cowpox Virus Infection in an Aborted Foal. ( 27159333 )
2016
30
Unusual presentations of feline cowpox. ( 27789864 )
2016
31
Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners. ( 26615189 )
2016
32
Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease. ( 25776759 )
2015
33
Comparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the Species- and Strain-Specific Proteome. ( 26556597 )
2015
34
Out of the Reservoir: Phenotypic and Genotypic Characterization of a Novel Cowpox Virus Isolated from a Common Vole. ( 26311891 )
2015
35
Cowpox Helped Against Smallpox; Will the Goat Lentivirus (Caprine Arthritis Encephalitis Virus) Help Against HIV-1? ( 25844817 )
2015
36
Characterization of a large, proteolytically processed cowpox virus membrane glycoprotein conserved in most chordopoxviruses. ( 25980741 )
2015
37
Real-time PCR assay for specific detection of cowpox virus. ( 25455900 )
2015
38
Cowpox after a cat scratch - case report from Poland. ( 26403114 )
2015
39
Severe Ocular Cowpox in a Human, Finland. ( 26583527 )
2015
40
Neurogenic inflammation and colliquative lymphadenitis with persistant orthopox virus DNA detection in a human case of cowpox virus infection transmitted by a domestic cat. ( 25641516 )
2015
41
Pulmonary cowpox in cats: five cases. ( 25972246 )
2015
42
A negative feedback modulator of antigen processing evolved from a frameshift in the cowpox virus genome. ( 25503639 )
2014
43
Molecular characterization and phylogenetics of Fennoscandian cowpox virus isolates based on the p4c and atip genes. ( 24972911 )
2014
44
Generation of a complete single-gene knockout bacterial artificial chromosome library of cowpox virus and identification of its essential genes. ( 24155400 )
2014
45
Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP. ( 25024387 )
2014
46
Fatal cowpox virus infection in cotton-top tamarins (Saguinus oedipus) in Germany. ( 24689730 )
2014
47
Elimination of A-type inclusion formation enhances cowpox virus replication in mice: implications for orthopoxvirus evolution. ( 24606683 )
2014
48
Identification of 10 cowpox virus proteins that are necessary for induction of hemorrhagic lesions (red pocks) on chorioallantoic membranes. ( 24850732 )
2014
49
Clinical Trials: naming confusion or YABA? ( 24978352 )
2014
50
A comparative study of self-report, urinalysis and hair analysis in the detection of methamphetamine in Yaba users. ( 25265778 )
2014

Variations for Cowpox

Expression for Cowpox

Search GEO for disease gene expression data for Cowpox.

Pathways for Cowpox

Pathways related to Cowpox according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 CASP1 CASP3 CASP5 CASP8 FAS IL6
2
Show member pathways
13.54 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS
3
Show member pathways
13.42 CASP3 CASP8 CXCL8 FAS GZMB IL6
4
Show member pathways
13.27 CASP3 CXCL8 FAS IL6 XIAP
5
Show member pathways
13.16 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS
6
Show member pathways
12.89 CASP1 CASP5 CASP8 CXCL8 FAS IL6
7
Show member pathways
12.86 CASP3 CASP8 FAS IL6
8
Show member pathways
12.86 CASP3 CASP8 CXCL8 FAS IL6
9
Show member pathways
12.83 CASP1 CASP3 CASP5 CASP8 FAS
10
Show member pathways
12.75 CASP3 CASP8 CXCL8 FAS GZMB IL6
11 12.7 CASP3 CASP8 CXCL8 FAS IL6 XIAP
12
Show member pathways
12.69 CASP1 CASP3 CASP5 CASP8 FAS IL6
13 12.66 CASP1 CASP3 CASP8 FAS
14
Show member pathways
12.66 CASP1 CASP8 CXCL8 IL6
15
Show member pathways
12.64 CASP1 CASP3 CASP8 FAS GZMB XIAP
16
Show member pathways
12.62 CASP1 CASP3 CASP8 FAS XIAP
17
Show member pathways
12.53 CASP1 CASP3 CASP5 CASP8 FAS
18
Show member pathways
12.44 CASP3 FAS GZMB KLRK1
19
Show member pathways
12.42 CASP1 CASP3 CASP8 FAS GZMB
20
Show member pathways
12.39 CASP1 CASP3 CASP8 CXCL8 FAS IL6
21
Show member pathways
12.28 CASP3 CASP8 CXCL8 IL6
22
Show member pathways
12.27 CASP3 CASP8 FAS
23
Show member pathways
12.22 CASP8 FAS XIAP
24
Show member pathways
12.16 CASP3 CASP8 XIAP
25 12.16 CXCL8 GZMB IL6
26
Show member pathways
12.16 CASP1 CASP8 FAS XIAP
27 12.14 CASP3 CASP8 IL6
28
Show member pathways
12.12 CASP1 CASP8 IL6
29
Show member pathways
12.1 CXCL8 FAS IL6
30 12.09 CASP3 CXCL8 IL6
31
Show member pathways
12.08 CASP1 CASP3 CASP5 CASP8 FAS
32 12.04 CASP1 CASP3 CASP5 CASP8
33
Show member pathways
12 CASP1 CXCL8 IL6 XIAP
34
Show member pathways
11.98 CASP3 CASP8 GZMB XIAP
35
Show member pathways
11.97 CASP1 CASP3 CASP5 CASP8
36 11.94 CASP3 CXCL8 IL6
37 11.91 CASP3 CASP8 FAS IL6
38
Show member pathways
11.89 CASP1 CASP3 CASP5 CASP8
39
Show member pathways
11.89 CASP1 CASP3 CASP8 FAS GZMB XIAP
40 11.88 CASP1 CASP3 CASP5 CASP8
41 11.85 CASP3 CXCL8 IL6
42 11.83 CASP3 CXCL8 IL6
43 11.78 CASP1 CXCL8 IL6
44
Show member pathways
11.75 CASP3 CASP8 FAS XIAP
45 11.69 CASP1 CASP3 CXCL8 IL6
46 11.64 CASP3 CXCL8 IL6
47 11.64 CASP3 CASP8 FAS XIAP
48 11.53 CASP3 CXCL8 IL6
49
Show member pathways
11.51 CASP3 CASP8 GZMB
50 11.5 CXCL8 IL6 KLRK1

GO Terms for Cowpox

Cellular components related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.43 CASP3 CASP8 FAS
2 CD95 death-inducing signaling complex GO:0031265 9.16 CASP8 FAS
3 NLRP1 inflammasome complex GO:0072558 8.96 CASP1 CASP5
4 death-inducing signaling complex GO:0031264 8.8 CASP3 CASP8 FAS

Biological processes related to Cowpox according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.88 CASP1 CASP3 CASP5 CASP8 GZMB
2 negative regulation of apoptotic process GO:0043066 9.85 CASP3 FAS IL6 XIAP
3 positive regulation of apoptotic process GO:0043065 9.8 CASP3 FAS IL6 KLRK1
4 apoptotic process GO:0006915 9.8 CASP1 CASP3 CASP5 CASP8 FAS GZMB
5 cytokine-mediated signaling pathway GO:0019221 9.76 CASP1 CASP3 CXCL8 IL6
6 regulation of apoptotic process GO:0042981 9.71 CASP1 CASP5 CASP8 FAS
7 cellular response to lipopolysaccharide GO:0071222 9.67 CASP1 CXCL8 IL6 KLRK1
8 cellular response to mechanical stimulus GO:0071260 9.62 CASP1 CASP5 CASP8 FAS
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 CASP8 FAS
10 response to antibiotic GO:0046677 9.58 CASP3 CASP8
11 response to tumor necrosis factor GO:0034612 9.57 CASP3 CASP8
12 natural killer cell activation GO:0030101 9.56 CASP8 KLRK1
13 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.54 CASP8 GZMB
14 natural killer cell mediated cytotoxicity GO:0042267 9.52 GZMB KLRK1
15 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.51 CASP8 FAS
16 execution phase of apoptosis GO:0097194 9.46 CASP1 CASP3 CASP5 CASP8
17 response to cobalt ion GO:0032025 9.43 CASP3 CASP8
18 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.35 CASP1 CASP3 CASP5 CASP8 FAS
19 apoptotic signaling pathway GO:0097190 9.02 CASP1 CASP3 CASP5 CASP8 FAS

Molecular functions related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.72 CASP1 CASP3 CASP5 CASP8 GZMB
2 cysteine-type peptidase activity GO:0008234 9.56 CASP1 CASP3 CASP5 CASP8
3 kinase binding GO:0019900 9.54 CASP1 FAS KLRK1
4 cysteine-type endopeptidase activity GO:0004197 9.46 CASP1 CASP3 CASP5 CASP8
5 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 9.43 CASP1 CASP3
6 death receptor binding GO:0005123 9.4 CASP3 CASP8
7 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.26 CASP1 CASP3 CASP5 CASP8
8 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 8.92 CASP1 CASP3 CASP5 CASP8

Sources for Cowpox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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