YABA
MCID: CWP001
MIFTS: 46

Cowpox (YABA)

Categories: Infectious diseases

Aliases & Classifications for Cowpox

MalaCards integrated aliases for Cowpox:

Name: Cowpox 12 76 55 44 15 73
Yaba 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8956
ICD10 33 B08.010
ICD9CM 35 051.01
MeSH 44 D015605
SNOMED-CT 68 70090004
UMLS 73 C0010232

Summaries for Cowpox

Disease Ontology : 12 A viral infectious disease that results in infection in rodents, cows, and humans, located in skin, has material basis in Cowpox virus, which is transmitted by contact with an infected animal. The infection results in_formation_of vesicopustular lesions on the hands or face.

MalaCards based summary : Cowpox, also known as yaba, is related to viral infectious disease and vaccinia. An important gene associated with Cowpox is CASP1 (Caspase 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. The drugs Haloperidol and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Cowpox is an infectious disease caused by the cowpox virus. The virus, part of the orthopoxvirus genus,... more...

Related Diseases for Cowpox

Diseases related to Cowpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 31.2 CXCL8 IL6 MX1
2 vaccinia 10.8
3 smallpox 10.5
4 monkeypox 10.4
5 cholestasis, benign recurrent intrahepatic, 2 10.2 CASP1 CASP8
6 israeli tick typhus 10.2 CASP1 CXCL8
7 recurrent corneal erosion 10.2 CXCL8 IL6
8 bagassosis 10.2 CXCL8 IL6
9 acute transverse myelitis 10.2 CXCL8 IL6
10 transverse myelitis 10.2 CXCL8 IL6
11 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6
12 post-transplant lymphoproliferative disease 10.2 CASP8 IL6
13 denture stomatitis 10.2 CXCL8 IL6
14 papillary conjunctivitis 10.2 CXCL8 IL6
15 funisitis 10.2 CXCL8 IL6
16 acute monoblastic leukemia 10.2 CXCL8 IL6
17 capillary leak syndrome 10.2 CXCL8 IL6
18 meconium aspiration syndrome 10.2 CXCL8 IL6
19 louse-borne relapsing fever 10.2 CXCL8 IL6
20 burn scar 10.2 CASP1 FAS
21 endometrial disease 10.2 CXCL8 IL6
22 vaginal disease 10.2 CXCL8 IL6
23 vaginitis 10.1 CXCL8 IL6
24 pyelitis 10.1 CXCL8 IL6
25 necrotizing fasciitis 10.1 CXCL8 IL6
26 encephalitis 10.1
27 fasciitis 10.1 CXCL8 IL6
28 viral meningitis 10.1 CXCL8 IL6
29 radiculopathy 10.1 CXCL8 IL6
30 bacteriuria 10.1 CXCL8 IL6
31 pulpitis 10.1 CXCL8 IL6
32 acute cystitis 10.1 CXCL8 IL6
33 middle ear disease 10.1 CXCL8 IL6
34 yellow fever 10.1
35 acute pyelonephritis 10.1 CXCL8 IL6
36 perinatal necrotizing enterocolitis 10.1 CXCL8 IL6
37 viral encephalitis 10.1 IL6 MX1
38 primary effusion lymphoma 10.1 CASP3 IL6
39 chlamydia 10.1 CASP1 CXCL8 IL6
40 nodular goiter 10.1 FAS IL6
41 lymphocytic gastritis 10.1 FAS GZMB
42 bacterial infectious disease 10.1 CASP1 CXCL8 IL6
43 lymphomatoid papulosis 10.1 FAS GZMB
44 lymphadenitis 10.1
45 pneumonia 10.1
46 influenza 10.1
47 venezuelan equine encephalitis 10.1
48 kaposi sarcoma 10.1 CASP8 CXCL8 IL6
49 traumatic brain injury 10.1 CASP3 IL6
50 rasmussen encephalitis 10.0 GZMB IL6

Graphical network of the top 20 diseases related to Cowpox:



Diseases related to Cowpox

Symptoms & Phenotypes for Cowpox

GenomeRNAi Phenotypes related to Cowpox according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS

MGI Mouse Phenotypes related to Cowpox:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 CASP1 CASP3 CASP8 FAS IL6 XIAP
2 integument MP:0010771 9.43 CASP1 CASP3 CASP8 FAS IL6 XIAP
3 renal/urinary system MP:0005367 9.02 CASP1 CASP3 CASP8 FAS IL6

Drugs & Therapeutics for Cowpox

Drugs for Cowpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Haloperidol Approved Phase 1, Phase 2 52-86-8 3559
2
Dopamine Approved Phase 1, Phase 2 51-61-6, 62-31-7 681
3 Immunoglobulins, Intravenous Phase 2
4 gamma-Globulins Phase 2
5 Antibodies Phase 2
6 Immunoglobulins Phase 2
7 Rho(D) Immune Globulin Phase 2
8 Immunologic Factors Phase 2
9 Vaccines Phase 2
10 Antipsychotic Agents Phase 1, Phase 2
11 Psychotropic Drugs Phase 1, Phase 2
12 Central Nervous System Depressants Phase 1, Phase 2
13 decanoic acid Phase 1, Phase 2
14 Dopamine Antagonists Phase 1, Phase 2
15 Antiemetics Phase 1, Phase 2
16 Neurotransmitter Agents Phase 1, Phase 2
17 Haloperidol decanoate Phase 1, Phase 2
18 Dopamine Agents Phase 1, Phase 2
19 Tranquilizing Agents Phase 1, Phase 2
20 Gastrointestinal Agents Phase 1, Phase 2
21 Autonomic Agents Phase 1, Phase 2
22 Peripheral Nervous System Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
2 Antipsychotic Effects of Sorghum Bicolor (JOBELYN) in the Treatment of Schizophrenia Not yet recruiting NCT02240173 Phase 1, Phase 2 Haloperidol
3 The Effectiveness of SMS in Improving Antiretroviral Medication Adherence Among Adolescents Living With HIV in Nigeria Active, not recruiting NCT03394391 Not Applicable

Search NIH Clinical Center for Cowpox

Cochrane evidence based reviews: cowpox

Genetic Tests for Cowpox

Anatomical Context for Cowpox

The Foundational Model of Anatomy Ontology organs/tissues related to Cowpox:

19
Skin

MalaCards organs/tissues related to Cowpox:

41
Skin, Monocytes, Brain, Kidney, Liver, Spinal Cord, Placenta

Publications for Cowpox

Articles related to Cowpox:

(show top 50) (show all 457)
# Title Authors Year
1
Edward Jenner's 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox. ( 29978749 )
2018
2
The Cowpox Controversy: Memory and the Politics of Public Health in Cuba. ( 29681552 )
2018
3
Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores. ( 29379051 )
2018
4
Cowpox Virus Infection. ( 29320650 )
2018
5
Atypical Cowpox Virus Infection in a Series of Cats. ( 29422319 )
2018
6
Cowpox virus infection in two brothers with possible human-to-human transmission. ( 29852532 )
2018
7
A Research Enclave in 1940s Nigeria: The Rockefeller Foundation Yellow Fever Research Institute at Yaba, Lagos, 1943-49. ( 29681554 )
2018
8
Phosphorylation of the Bacillus subtilis Replication Controller YabA Plays a Role in Regulation of Sporulation and Biofilm Formation. ( 29619013 )
2018
9
Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine. ( 29137821 )
2017
10
Novel characteristics identified in two cases of feline cowpox virus infection. ( 28839944 )
2017
11
Epidemiological Investigations of Four Cowpox Virus Outbreaks in Alpaca Herds, Germany. ( 29156539 )
2017
12
Generalised cowpox virus infection. ( 28669644 )
2017
13
Two Distinct Clinical Courses of Human Cowpox, Germany, 2015. ( 29215552 )
2017
14
Experimental Cowpox Virus (CPXV) Infections of Bank Voles: Exceptional Clinical Resistance and Variable Reservoir Competence. ( 29257111 )
2017
15
Seasonal recurrence of cowpox virus outbreaks in captive cheetahs (Acinonyx jubatus). ( 29121668 )
2017
16
Cowpox Virus: A New and Armed Oncolytic Poxvirus. ( 28951885 )
2017
17
Cowpox virus: What's in a Name? ( 28486428 )
2017
18
Vaccinia virus and Cowpox virus are not susceptible to the interferon-induced antiviral protein MxA. ( 28727764 )
2017
19
Classification of Cowpox Viruses into Several Distinct Clades and Identification of a Novel Lineage. ( 28604604 )
2017
20
Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells. ( 29363167 )
2017
21
Cowpox virus infection in a child after contact with a domestic cat: a case report. ( 28368077 )
2017
22
Histopathological and Immunohistochemical Studies of Cowpox Virus Replication in a Three-Dimensional Skin Model. ( 27291992 )
2016
23
Generalized Cowpox Virus Infection in a Patient with HIV, Germany, 2012. ( 26891134 )
2016
24
Fatal disseminated cowpox virus infection in an adolescent renal transplant recipient. ( 27796621 )
2016
25
Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease. ( 27166137 )
2016
26
Cowpox in a human, Russia, 2015. ( 27917750 )
2016
27
Fatal Cowpox Virus Infection in an Aborted Foal. ( 27159333 )
2016
28
Unusual presentations of feline cowpox. ( 27789864 )
2016
29
Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners. ( 26615189 )
2016
30
Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease. ( 25776759 )
2015
31
Comparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the Species- and Strain-Specific Proteome. ( 26556597 )
2015
32
Out of the Reservoir: Phenotypic and Genotypic Characterization of a Novel Cowpox Virus Isolated from a Common Vole. ( 26311891 )
2015
33
Cowpox Helped Against Smallpox; Will the Goat Lentivirus (Caprine Arthritis Encephalitis Virus) Help Against HIV-1? ( 25844817 )
2015
34
Characterization of a large, proteolytically processed cowpox virus membrane glycoprotein conserved in most chordopoxviruses. ( 25980741 )
2015
35
Real-time PCR assay for specific detection of cowpox virus. ( 25455900 )
2015
36
Cowpox after a cat scratch - case report from Poland. ( 26403114 )
2015
37
Severe Ocular Cowpox in a Human, Finland. ( 26583527 )
2015
38
Neurogenic inflammation and colliquative lymphadenitis with persistant orthopox virus DNA detection in a human case of cowpox virus infection transmitted by a domestic cat. ( 25641516 )
2015
39
Pulmonary cowpox in cats: five cases. ( 25972246 )
2015
40
A negative feedback modulator of antigen processing evolved from a frameshift in the cowpox virus genome. ( 25503639 )
2014
41
Molecular characterization and phylogenetics of Fennoscandian cowpox virus isolates based on the p4c and atip genes. ( 24972911 )
2014
42
Generation of a complete single-gene knockout bacterial artificial chromosome library of cowpox virus and identification of its essential genes. ( 24155400 )
2014
43
Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP. ( 25024387 )
2014
44
Fatal cowpox virus infection in cotton-top tamarins (Saguinus oedipus) in Germany. ( 24689730 )
2014
45
Elimination of A-type inclusion formation enhances cowpox virus replication in mice: implications for orthopoxvirus evolution. ( 24606683 )
2014
46
Identification of 10 cowpox virus proteins that are necessary for induction of hemorrhagic lesions (red pocks) on chorioallantoic membranes. ( 24850732 )
2014
47
Clinical Trials: naming confusion or YABA? ( 24978352 )
2014
48
A comparative study of self-report, urinalysis and hair analysis in the detection of methamphetamine in Yaba users. ( 25265778 )
2014
49
Cowpox: what do a dairymaid and a lab technician have in common? ( 22560271 )
2013
50
Clinicopathological findings in persistent corneal cowpox infection. ( 23765283 )
2013

Variations for Cowpox

Expression for Cowpox

Search GEO for disease gene expression data for Cowpox.

Pathways for Cowpox

Pathways related to Cowpox according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 CASP1 CASP3 CASP5 CASP8 FAS IL6
2
Show member pathways
13.55 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS
3
Show member pathways
13.43 CASP3 CASP8 CXCL8 FAS GZMB IL6
4
Show member pathways
13.28 CASP3 CXCL8 FAS IL6 XIAP
5
Show member pathways
13.23 CASP1 CASP3 CXCL8 IL6 MX1
6
Show member pathways
13.16 CASP1 CASP3 CASP5 CASP8 CXCL8 FAS
7
Show member pathways
12.96 CASP3 CASP8 CXCL8 FAS IL6
8
Show member pathways
12.9 CASP3 CASP8 FAS IL6 MX1
9
Show member pathways
12.83 CASP1 CASP3 CASP5 CASP8 FAS
10
Show member pathways
12.75 CASP3 CASP8 CXCL8 FAS GZMB IL6
11
Show member pathways
12.73 CASP1 CASP3 CASP5 CASP8 FAS IL6
12
Show member pathways
12.72 CASP1 CASP5 CASP8 CXCL8 FAS IL6
13 12.69 CASP3 CASP8 CXCL8 FAS IL6 XIAP
14 12.67 CASP1 CASP3 CASP8 FAS
15
Show member pathways
12.66 CASP1 CASP8 CXCL8 IL6
16
Show member pathways
12.64 CASP1 CASP3 CASP8 FAS GZMB XIAP
17
Show member pathways
12.63 CASP1 CASP3 CASP8 FAS XIAP
18
Show member pathways
12.54 CASP1 CASP3 CASP5 CASP8 FAS
19
Show member pathways
12.46 CASP1 CASP3 CASP5 CASP8 XIAP
20
Show member pathways
12.42 CASP1 CASP3 CASP8 FAS GZMB
21
Show member pathways
12.39 CASP1 CASP3 CASP8 CXCL8 FAS IL6
22
Show member pathways
12.29 CASP3 CASP8 CXCL8 IL6
23
Show member pathways
12.28 CASP3 CASP8 FAS
24
Show member pathways
12.25 CASP3 CASP8 FAS XIAP
25 12.25 CASP3 CASP8 FAS IL6
26
Show member pathways
12.23 CASP8 FAS XIAP
27
Show member pathways
12.17 CASP1 CASP8 FAS XIAP
28
Show member pathways
12.16 CASP3 CASP8 XIAP
29 12.16 CXCL8 GZMB IL6
30 12.14 CASP3 CASP8 IL6
31
Show member pathways
12.12 CASP1 CASP8 IL6
32
Show member pathways
12.1 CXCL8 FAS IL6
33
Show member pathways
12.1 CASP1 CASP3 CASP5 CASP8 FAS
34 12.09 CASP3 CXCL8 IL6
35 12.05 CASP1 CASP3 CASP5 CASP8
36
Show member pathways
12 CASP1 CXCL8 IL6 XIAP
37
Show member pathways
11.99 CASP3 CASP8 GZMB XIAP
38
Show member pathways
11.99 CASP1 CASP3 CASP8 FAS GZMB XIAP
39
Show member pathways
11.97 CASP1 CASP3 CASP5 CASP8
40 11.95 CASP3 CXCL8 IL6
41 11.91 CASP3 CASP8 FAS IL6
42
Show member pathways
11.89 CASP1 CASP3 CASP5 CASP8
43 11.89 CASP1 CASP3 CASP5 CASP8
44 11.86 CASP3 CXCL8 IL6
45 11.84 CASP3 CXCL8 IL6
46 11.78 CASP1 CXCL8 IL6
47
Show member pathways
11.75 CASP3 CASP8 FAS XIAP
48 11.69 CASP1 CASP3 CXCL8 IL6
49 11.65 CASP3 CXCL8 IL6
50 11.64 CASP3 CASP8 FAS XIAP

GO Terms for Cowpox

Cellular components related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.43 CASP3 CASP8 FAS
2 CD95 death-inducing signaling complex GO:0031265 9.16 CASP8 FAS
3 NLRP1 inflammasome complex GO:0072558 8.96 CASP1 CASP5
4 death-inducing signaling complex GO:0031264 8.8 CASP3 CASP8 FAS

Biological processes related to Cowpox according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 CASP1 CASP3 CASP5 CASP8 GZMB
2 negative regulation of apoptotic process GO:0043066 9.83 CASP3 FAS IL6 XIAP
3 cytokine-mediated signaling pathway GO:0019221 9.73 CASP1 CASP3 CXCL8 IL6
4 cellular response to lipopolysaccharide GO:0071222 9.67 CASP1 CXCL8 IL6
5 regulation of apoptotic process GO:0042981 9.67 CASP1 CASP5 CASP8 FAS
6 cellular response to mechanical stimulus GO:0071260 9.62 CASP1 CASP5 CASP8 FAS
7 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 CASP8 FAS
8 execution phase of apoptosis GO:0097194 9.56 CASP1 CASP3 CASP5 CASP8
9 response to antibiotic GO:0046677 9.55 CASP3 CASP8
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.55 CASP1 CASP3 CASP5 CASP8 FAS
11 response to tumor necrosis factor GO:0034612 9.54 CASP3 CASP8
12 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.51 CASP8 GZMB
13 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.48 CASP8 FAS
14 response to cobalt ion GO:0032025 9.4 CASP3 CASP8
15 apoptotic signaling pathway GO:0097190 9.35 CASP1 CASP3 CASP5 CASP8 FAS
16 apoptotic process GO:0006915 9.23 CASP1 CASP3 CASP5 CASP8 FAS GZMB

Molecular functions related to Cowpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.83 CASP1 CASP8 FAS MX1 XIAP
2 peptidase activity GO:0008233 9.72 CASP1 CASP3 CASP5 CASP8 GZMB
3 cysteine-type peptidase activity GO:0008234 9.56 CASP1 CASP3 CASP5 CASP8
4 cysteine-type endopeptidase activity GO:0004197 9.46 CASP1 CASP3 CASP5 CASP8
5 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 9.4 CASP1 CASP3
6 death receptor binding GO:0005123 9.37 CASP3 CASP8
7 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.26 CASP1 CASP3 CASP5 CASP8
8 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 8.92 CASP1 CASP3 CASP5 CASP8

Sources for Cowpox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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