Aliases & Classifications for Cranial Nerve Disease

MalaCards integrated aliases for Cranial Nerve Disease:

Name: Cranial Nerve Disease 12 15
Disorder of Cranial Nerve 12
Cranial Nerve Disorder 12
Cranial Nerve Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5656
ICD9CM 34 352.9
MeSH 43 D003389
NCIt 49 C26733
SNOMED-CT 67 73013002
ICD10 32 G52.8 G52.9 G53
UMLS 71 C0010266

Summaries for Cranial Nerve Disease

Disease Ontology : 12 A neuropathy that is located in one of the twelve cranial nerves.

MalaCards based summary : Cranial Nerve Disease, also known as disorder of cranial nerve, is related to optic nerve disease and neuritis, and has symptoms including ophthalmoplegia and circumoral paresthesia. An important gene associated with Cranial Nerve Disease is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Glucose / Energy Metabolism and NOD-like receptor signaling pathway. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include one of the twelve cranial nerves, bone and spinal cord, and related phenotypes are cellular and cardiovascular system

Wikipedia : 74 Cranial nerve disease is an impaired functioning of one of the twelve cranial nerves. Although it could... more...

Related Diseases for Cranial Nerve Disease

Diseases related to Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 31.6 WFS1 SERPINA3 POLG OPA3 OPA1 MT-TK
2 neuritis 30.8 MT-ND4 MOG AQP4
3 acute retrobulbar neuritis 30.8 MT-ND4 AQP4
4 muscular disease 30.2 SERPINA3 POLG MT-TK MT-ND6 MT-ND4 MFN2
5 third cranial nerve disease 12.4
6 glossopharyngeal nerve disease 12.1
7 cranial nerve palsy 11.5
8 abducens nerve disease 11.4
9 vascular myelopathy 10.8 MOG AQP4
10 skin amelanotic melanoma 10.7 OPA1 MFN1
11 partial optic atrophy 10.7 MT-ND4 MOG
12 leber optic atrophy and dystonia 10.7 MT-ND6 MT-ND4 MT-ND1
13 thyroid gland hurthle cell carcinoma 10.7 SERPINA3 AQP4
14 optic papillitis 10.7 MOG CD40LG AQP4
15 autoimmune disease of peripheral nervous system 10.7 MOG CD40LG AQP4
16 optic atrophy 1 10.7 OPA1 MFN1 DNM1L
17 balo concentric sclerosis 10.7 MOG AQP4
18 hereditary optic neuropathy 10.7 MT-ND6 MT-ND4 MT-ND1
19 communicating hydrocephalus 10.7 SERPINA3 ERCC6 AQP4
20 tritanopia 10.7 OPA3 MT-ND4 DNM1L
21 gastric squamous cell carcinoma 10.7 SERPINA3 CCR6
22 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 10.7 OPA1 MFN2
23 myotonic cataract 10.7 POLG MT-TK KIF21A
24 lacrimal apparatus disease 10.7 CRYAA CD40LG CCR6
25 central nervous system vasculitis 10.7 SERPINA3 CD40LG CCR6
26 autoimmune optic neuritis 10.7 MOG AQP4
27 amblyopia 10.7 MT-ND4 KIF21A CRYAA
28 orbital disease 10.7 KIF21A ERCC6 CD40LG
29 autoimmune disease of skin and connective tissue 10.7 SERPINA3 CD40LG CCR6
30 acute disseminated encephalomyelitis 10.7 MOG CD40LG CCR6 AQP4
31 myelitis 10.7 MOG CD40LG CCR6 AQP4
32 viral encephalitis 10.7 MOG CD40LG CCR6
33 cecal disease 10.7 SERPINA3 CD40LG CCR6
34 pyelitis 10.7 SERPINA3 CD40LG CCR6
35 spinal cord disease 10.7 MOG CD40LG CCR6 AQP4
36 plasma protein metabolism disease 10.7 SERPINA3 CD40LG CCR6
37 neuromyelitis optica 10.7 MOG CD40LG AQP4
38 electroclinical syndrome 10.7 POLG MT-TK CRYAA
39 neonatal period electroclinical syndrome 10.7 POLG MT-TK MT-ND4
40 middle ear disease 10.7 SERPINA3 CD40LG CCR6
41 behr syndrome 10.7 OPA3 OPA1
42 internuclear ophthalmoplegia 10.7 MOG AQP4
43 coccidiosis 10.7 SERPINA3 CD40LG CCR6
44 neuroretinitis 10.7 CD40LG AQP4
45 pearson marrow-pancreas syndrome 10.7 POLG MT-TK MT-ND6 MT-ND4
46 alkhurma hemorrhagic fever 10.7 CD40LG ANTXR2
47 facial paralysis 10.7 KIF21A CD40LG ANTXR2
48 facial nerve disease 10.7 KIF21A CD40LG ANTXR2
49 sparganosis 10.7 MT-ND4 MT-ND1
50 intraocular pressure quantitative trait locus 10.7 SERPINA3 OPA1 CRYAA AQP4

Graphical network of the top 20 diseases related to Cranial Nerve Disease:



Diseases related to Cranial Nerve Disease

Symptoms & Phenotypes for Cranial Nerve Disease

UMLS symptoms related to Cranial Nerve Disease:


ophthalmoplegia, circumoral paresthesia

MGI Mouse Phenotypes related to Cranial Nerve Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 ANTXR2 CD40LG DNM1L ERCC6 KIF21A MFN1
2 cardiovascular system MP:0005385 10.02 ANTXR2 AQP4 CCR6 CD40LG DNM1L MFN2
3 growth/size/body region MP:0005378 9.93 AQP4 DNM1L ERCC6 KIF21A MFN1 MFN2
4 muscle MP:0005369 9.61 DNM1L ERCC6 KIF21A MFN2 MOG MT-ND6
5 nervous system MP:0003631 9.44 AQP4 CCR6 CD40LG DNM1L ERCC6 KIF21A

Drugs & Therapeutics for Cranial Nerve Disease

Drugs for Cranial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
5 Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
6
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
7
Cortisone Experimental Phase 1, Phase 2 53-06-5 222786
8
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
9 Protective Agents Phase 1, Phase 2
10 Gastrointestinal Agents Phase 1, Phase 2
11 Antiemetics Phase 1, Phase 2
12 Methylprednisolone Acetate Phase 1, Phase 2
13 Anti-Inflammatory Agents Phase 1, Phase 2
14 Hormone Antagonists Phase 1, Phase 2
15 Neuroprotective Agents Phase 1, Phase 2
16 Autonomic Agents Phase 1, Phase 2
17 Antineoplastic Agents, Hormonal Phase 1, Phase 2
18 glucocorticoids Phase 1, Phase 2
19 Hormones Phase 1, Phase 2
20 Hematinics Phase 2
21 Ferrosoferric Oxide Phase 2
22 Pharmaceutical Solutions Phase 2
23 Parenteral Nutrition Solutions Phase 2
24
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
25 Antioxidants
26 Central Nervous System Depressants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial Recruiting NCT04151082 Phase 1, Phase 2 Methylprednisolone;Prednisone
2 The Feasibility of Steady State CBV Mapping Using Ferumoxytol Immediately After Gadolinium Enhanced MRI of the CNS Recruiting NCT03270059 Phase 2 Ferumoxytol;Gadolinium
3 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
4 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
5 Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit Recruiting NCT03659760
6 Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy Recruiting NCT02978911
7 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Recruiting NCT03206541
8 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cranial Nerve Disease

Genetic Tests for Cranial Nerve Disease

Anatomical Context for Cranial Nerve Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cranial Nerve Disease:

19
One Of The Twelve Cranial Nerves

MalaCards organs/tissues related to Cranial Nerve Disease:

40
Bone, Spinal Cord, Skin, Olfactory Bulb, Pituitary, Eye, Lymph Node

Publications for Cranial Nerve Disease

Articles related to Cranial Nerve Disease:

(show all 20)
# Title Authors PMID Year
1
Relationship of Inflammation with Trigeminal Neuralgia: A Cohort Study. 61
31609955 2019
2
[Application of complete endoscopic technique in microvascular decompression related tovertebrobasilar artery compression]. 61
31510719 2019
3
Low Uric Acid Indicates Risk of Incidence of Trigeminal Neuralgia. 61
30939556 2019
4
Effects of Depression and Anxiety on Microvascular Decompression Outcome for Trigeminal Neuralgia Patients. 61
31071444 2019
5
MR Neurographic Evaluation of Facial and Neck Pain: Normal and Abnormal Craniospinal Nerves below the Skull Base. 61
30207933 2018
6
Usefulness of Totally Implantable Central Venous Access Devices in Elderly Patients: A Retrospective Study. 61
29353284 2018
7
Treatment of Posterior Inferior Cerebellar Artery Adhesion on Petrous Bone During Microvascular Decompression Procedure for Hemifacial Spasm: Technique Note. 61
28863115 2017
8
End-organ radiographic manifestations of cranial neuropathies: A concise review. 61
28364580 2017
9
[The Development of a Normal Database of Elderly People for Use with the Statistical Analysis Software Easy Z-score Imaging System with 99mTc-ECD SPECT]. 61
27263270 2015
10
Multiple synchronous sites of origin of vestibular schwannomas in neurofibromatosis Type 2. 61
26104281 2015
11
Clinical Characteristics and Treatment of Trigeminal Neuralgia Following Herpes Zoster. 61
26167998 2015
12
Advances in diagnosis and non-surgical treatment of Bell's palsy. 61
29937775 2015
13
[Clinicopathological study of acute esophageal mucosal lesion]. 61
23831655 2013
14
[Prognostic factors in patients undergoing percutaneous endoscopic gastrostomy]. 61
23925103 2013
15
Gene expression changes in the olfactory bulb of mice induced by exposure to diesel exhaust are dependent on animal rearing environment. 61
23940539 2013
16
[The normal cranial nerves in MRI. Description and visualization frequency]. 61
2056476 1991
17
Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198. 61
182313 1976
18
Inferior rectus palsies as a manifestation of atypical IIIrd cranial nerve disease. 61
1200458 1975
19
Cranial nerve disease. 61
4304044 1967
20
Ocular manifestations of cranial nerve disease. 61
13885420 1961

Variations for Cranial Nerve Disease

Expression for Cranial Nerve Disease

Search GEO for disease gene expression data for Cranial Nerve Disease.

Pathways for Cranial Nerve Disease

Pathways related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 WFS1 OPA1 MFN2 MFN1
2 11.18 MFN2 MFN1 DNM1L ANTXR2

GO Terms for Cranial Nerve Disease

Cellular components related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.22 WFS1 POLG OPA1 MT-ND6 MT-ND4 MT-ND1
2 mitochondrion GO:0005739 9.86 POLG OPA3 OPA1 MT-ND4 MT-ND1 MFN2
3 mitochondrial outer membrane GO:0005741 9.62 OPA1 MFN2 MFN1 DNM1L
4 external side of plasma membrane GO:0009897 9.55 MOG CD40LG CCR6 AQP4 ANTXR2
5 respiratory chain GO:0070469 9.54 MT-ND6 MT-ND4 MT-ND1
6 mitochondrial membrane GO:0031966 9.02 OPA1 MT-ND6 MT-ND4 MT-ND1 DNM1L
7 intrinsic component of mitochondrial outer membrane GO:0031306 8.96 MFN2 MFN1

Biological processes related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.71 WFS1 OPA3 OPA1 CRYAA
2 GTP metabolic process GO:0046039 9.43 OPA1 MFN1
3 mitochondrial respiratory chain complex I assembly GO:0032981 9.43 MT-ND6 MT-ND4 MT-ND1
4 mitochondrion localization GO:0051646 9.37 MFN2 MFN1
5 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.33 MT-ND6 MT-ND4 MT-ND1
6 intracellular distribution of mitochondria GO:0048312 9.32 OPA1 DNM1L
7 mitochondrion morphogenesis GO:0070584 9.13 OPA3 OPA1 DNM1L
8 mitochondrial fusion GO:0008053 8.8 OPA1 MFN2 MFN1

Molecular functions related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase activity GO:0003954 8.96 MT-ND4 MT-ND1
2 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.8 MT-ND6 MT-ND4 MT-ND1

Sources for Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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