Aliases & Classifications for Cranial Nerve Disease

MalaCards integrated aliases for Cranial Nerve Disease:

Name: Cranial Nerve Disease 12 15
Disorder of Cranial Nerve 12
Cranial Nerve Disorder 12
Cranial Nerve Diseases 72


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Disease Ontology 12 DOID:5656
ICD9CM 35 352.9
MeSH 44 D003389
NCIt 50 C26733
SNOMED-CT 68 73013002
ICD10 33 G52.8 G52.9 G53
UMLS 72 C0010266

Summaries for Cranial Nerve Disease

Disease Ontology : 12 A neuropathy that is located in one of the twelve cranial nerves.

MalaCards based summary : Cranial Nerve Disease, also known as disorder of cranial nerve, is related to neuritis and optic nerve disease, and has symptoms including ophthalmoplegia and circumoral paresthesia. An important gene associated with Cranial Nerve Disease is AQP4 (Aquaporin 4), and among its related pathways/superpathways is Cellular roles of Anthrax toxin. The drugs Pharmaceutical Solutions and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and olfactory bulb, and related phenotypes are cellular and nervous system

Wikipedia : 75 Cranial nerve disease is an impaired functioning of one of the twelve cranial nerves. Although it could... more...

Related Diseases for Cranial Nerve Disease

Diseases related to Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 neuritis 30.6 MOG MBP AQP4
2 optic nerve disease 30.3 WFS1 OPA3 OPA1 MT-ND6 MT-ND4 MT-ND1
3 third cranial nerve disease 12.4
4 glossopharyngeal nerve disease 12.1
5 cranial nerve palsy 11.5
6 abducens nerve disease 11.4
7 fibrosis of extraocular muscles, congenital, 2 10.7 PHOX2A KIF21A
8 allergic encephalomyelitis 10.7 MOG MBP
9 behr syndrome 10.7 OPA3 OPA1
10 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 10.7 OPA3 OPA1
11 central pontine myelinolysis 10.6 MBP AQP4
12 nervous system disease 10.6 MOG MBP AQP4
13 scotoma 10.6 OPA1 MT-ND4
14 leber optic atrophy 10.6 MT-ND6 MT-ND4 MT-ND1
15 leber optic atrophy and dystonia 10.6 MT-ND6 MT-ND4 MT-ND1
16 alexia 10.6 MBP AQP4
17 balo concentric sclerosis 10.6 MOG MBP AQP4
18 internuclear ophthalmoplegia 10.6 MOG MBP AQP4
19 acute disseminated encephalomyelitis 10.6 MOG MBP AQP4
20 myelitis 10.6 MOG MBP AQP4
21 autoimmune optic neuritis 10.6 MOG MBP AQP4
22 spinal cord disease 10.6 MOG MBP AQP4
23 hypotropia 10.6 PHOX2A KIF21A FRMD7
24 neuromyelitis optica 10.6 MOG MBP AQP4
25 inhalation anthrax 10.6 ANTXR2 ANTXR1
26 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 10.6 MT-ND6 MT-ND4 MT-ND1
27 autoimmune disease of central nervous system 10.6 MOG MBP AQP4
28 mitochondrial myopathy 10.6 MT-ND6 MT-ND4 MT-ND1
29 lactic acidosis 10.6 MT-ND6 MT-ND4 MT-ND1
30 ocular motility disease 10.6 PHOX2A KIF21A FRMD7
31 relapsing-remitting multiple sclerosis 10.6 MOG MBP AQP4
32 optic atrophy 1 10.5 OPA1 MFN2
33 panencephalitis, subacute sclerosing 10.5 MOG MBP
34 spastic paraplegia 7, autosomal recessive 10.5 OPA1 MT-ND4 MFN2
35 immune system disease 10.5 MOG MBP AQP4
36 mitochondrial encephalomyopathy 10.5 MT-ND6 MT-ND4 MT-ND1
37 optic neuritis 10.5 MT-ND4 MOG MBP AQP4
38 trigeminal nerve disease 10.5 MBD1 LIPN
39 exotropia 10.4 PHOX2A KIF21A
40 hypoglossal nerve disease 10.4
41 multiple cranial nerve palsy 10.4
42 olfactory nerve disease 10.4
43 ptosis 10.4 PHOX2A OPA1 KIF21A
44 strabismus 10.4 PHOX2A KIF21A FRMD7
45 anthrax disease 10.4 ANTXR2 ANTXR1
46 demyelinating disease 10.4 MOG MBP CD40LG AQP4
47 central nervous system disease 10.4 MOG MBP AQP4
48 neuropathy 10.3 MT-ND6 MT-ND4 MT-ND1 MFN2
49 kearns-sayre syndrome 10.3 PHOX2A MT-ND6 MT-ND4 MT-ND1 KIF21A
50 facial nerve disease 10.3 PHOX2A MARVELD1 LIPN KIF21A

Graphical network of the top 20 diseases related to Cranial Nerve Disease:

Diseases related to Cranial Nerve Disease

Symptoms & Phenotypes for Cranial Nerve Disease

UMLS symptoms related to Cranial Nerve Disease:

ophthalmoplegia, circumoral paresthesia

MGI Mouse Phenotypes related to Cranial Nerve Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 ANTXR1 ANTXR2 CD40LG MBD1 MBP MFN2
2 nervous system MP:0003631 9.32 AQP4 CD40LG MBD1 MBP MFN2 MOG

Drugs & Therapeutics for Cranial Nerve Disease

Drugs for Cranial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Hematinics Phase 2
3 Parenteral Nutrition Solutions Phase 2
4 Ferrosoferric Oxide Phase 2
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
6 Antioxidants
7 Protective Agents
8 Central Nervous System Depressants

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 The Feasibility of Steady State CBV Mapping Using Ferumoxytol Immediately After Gadolinium Enhanced MRI of the CNS Recruiting NCT03270059 Phase 2 Ferumoxytol;Gadolinium
2 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
3 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
4 Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit Recruiting NCT03659760
5 Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy Recruiting NCT02978911
6 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Recruiting NCT03206541
7 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cranial Nerve Disease

Genetic Tests for Cranial Nerve Disease

Anatomical Context for Cranial Nerve Disease

MalaCards organs/tissues related to Cranial Nerve Disease:

Bone, Pituitary, Olfactory Bulb

The Foundational Model of Anatomy Ontology organs/tissues related to Cranial Nerve Disease:

One Of The Twelve Cranial Nerves

Publications for Cranial Nerve Disease

Articles related to Cranial Nerve Disease:

(show all 18)
# Title Authors PMID Year
Effects of Depression and Anxiety on Microvascular Decompression Outcome for Trigeminal Neuralgia Patients. 38
31071444 2019
Low Uric Acid Indicates Risk of Incidence of Trigeminal Neuralgia. 38
30939556 2019
MR Neurographic Evaluation of Facial and Neck Pain: Normal and Abnormal Craniospinal Nerves below the Skull Base. 38
30207933 2018
Usefulness of Totally Implantable Central Venous Access Devices in Elderly Patients: A Retrospective Study. 38
29353284 2018
Treatment of Posterior Inferior Cerebellar Artery Adhesion on Petrous Bone During Microvascular Decompression Procedure for Hemifacial Spasm: Technique Note. 38
28863115 2017
End-organ radiographic manifestations of cranial neuropathies: A concise review. 38
28364580 2017
[The Development of a Normal Database of Elderly People for Use with the Statistical Analysis Software Easy Z-score Imaging System with 99mTc-ECD SPECT]. 38
27263270 2015
Multiple synchronous sites of origin of vestibular schwannomas in neurofibromatosis Type 2. 38
26104281 2015
Clinical Characteristics and Treatment of Trigeminal Neuralgia Following Herpes Zoster. 38
26167998 2015
Advances in diagnosis and non-surgical treatment of Bell's palsy. 38
29937775 2015
[Clinicopathological study of acute esophageal mucosal lesion]. 38
23831655 2013
[Prognostic factors in patients undergoing percutaneous endoscopic gastrostomy]. 38
23925103 2013
Gene expression changes in the olfactory bulb of mice induced by exposure to diesel exhaust are dependent on animal rearing environment. 38
23940539 2013
[The normal cranial nerves in MRI. Description and visualization frequency]. 38
2056476 1991
Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198. 38
182313 1976
Inferior rectus palsies as a manifestation of atypical IIIrd cranial nerve disease. 38
1200458 1975
Cranial nerve disease. 38
4304044 1967
Ocular manifestations of cranial nerve disease. 38
13885420 1961

Variations for Cranial Nerve Disease

Expression for Cranial Nerve Disease

Search GEO for disease gene expression data for Cranial Nerve Disease.

Pathways for Cranial Nerve Disease

Pathways related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.97 ANTXR2 ANTXR1

GO Terms for Cranial Nerve Disease

Cellular components related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.35 MOG CD40LG AQP4 ANTXR2 ANTXR1
2 respiratory chain GO:0070469 9.33 MT-ND6 MT-ND4 MT-ND1
3 mitochondrial membrane GO:0031966 8.92 OPA1 MT-ND6 MT-ND4 MT-ND1

Biological processes related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion morphogenesis GO:0070584 9.32 OPA3 OPA1
2 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.26 WFS1 OPA1
3 mitochondrial fusion GO:0008053 9.16 OPA1 MFN2
4 reproductive process GO:0022414 8.96 ANTXR2 ANTXR1
5 mitochondrial respiratory chain complex I assembly GO:0032981 8.8 MT-ND6 MT-ND4 MT-ND1

Molecular functions related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase activity GO:0003954 9.16 MT-ND4 MT-ND1
2 structural constituent of myelin sheath GO:0019911 8.96 MBP MARVELD1
3 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.8 MT-ND6 MT-ND4 MT-ND1

Sources for Cranial Nerve Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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