Aliases & Classifications for Cranial Nerve Disease

MalaCards integrated aliases for Cranial Nerve Disease:

Name: Cranial Nerve Disease 12 15
Disorder of Cranial Nerve 12
Cranial Nerve Disorder 12
Cranial Nerve Diseases 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5656
ICD9CM 34 352.9
MeSH 44 D003389
NCIt 50 C26733
SNOMED-CT 67 73013002
ICD10 32 G52.8 G52.9 G53
UMLS 70 C0010266

Summaries for Cranial Nerve Disease

Disease Ontology : 12 A neuropathy that is located in one of the twelve cranial nerves.

MalaCards based summary : Cranial Nerve Disease, also known as disorder of cranial nerve, is related to optic nerve disease and glossopharyngeal nerve disease, and has symptoms including ophthalmoplegia and circumoral paresthesia. An important gene associated with Cranial Nerve Disease is AQP4 (Aquaporin 4), and among its related pathways/superpathways is Mitophagy - animal. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include one of the twelve cranial nerves, olfactory bulb and pituitary, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia : 73 Cranial nerve disease is an impaired functioning of one of the twelve cranial nerves. Although it could... more...

Related Diseases for Cranial Nerve Disease

Diseases related to Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 31.5 WFS1 SERPINA3 POLG OPA3 MT-ND6 MT-ND4
2 glossopharyngeal nerve disease 11.4
3 third cranial nerve disease 11.3
4 abducens nerve disease 11.2
5 vascular myelopathy 10.5 MOG AQP4
6 internuclear ophthalmoplegia 10.5 MOG ERCC6 AQP4
7 nutritional optic neuropathy 10.5 OPA3 AQP4
8 acute disseminated encephalomyelitis 10.5 MOG CCR6 AQP4
9 myelitis 10.5 MOG CCR6 AQP4
10 charcot-marie-tooth disease, axonal, type 2l 10.5 MFN2 DCAF8 CRYAA
11 transverse myelitis 10.5 MOG CCR6 AQP4
12 balo concentric sclerosis 10.5 MOG AQP4
13 autoimmune disease of peripheral nervous system 10.5 MOG CCR6 AQP4
14 acute retrobulbar neuritis 10.5 MT-ND4 AQP4
15 orbital disease 10.5 KIF21A ERCC6 CRYAA
16 myotonic cataract 10.5 POLG KIF21A
17 spinal cord disease 10.5 MOG CCR6 AQP4
18 communicating hydrocephalus 10.5 SERPINA3 ERCC6 AQP4
19 optic atrophy 3, autosomal dominant 10.5 OPA3 MFN2 MFN1 CRYAA
20 pearson marrow-pancreas syndrome 10.5 POLG MT-ND6 MT-ND4
21 neuropathy, ataxia, and retinitis pigmentosa 10.5 POLG MT-ND6 MT-ND4
22 autoimmune optic neuritis 10.5 MOG AQP4
23 optic neuritis 10.5 MT-ND6 MT-ND4 MOG AQP4
24 amblyopia 10.5 MT-ND4 KIF21A CRYAA
25 gastric squamous cell carcinoma 10.5 SERPINA3 CCR6
26 hypotropia 10.5 KIF21A FRMD7
27 combined oxidative phosphorylation deficiency 7 10.5 MFN2 AQP4
28 esotropia 10.5 KIF21A FRMD7 CRYAA
29 marinesco-sjogren syndrome 10.5 POLG OPA3 CRYAA
30 skin amelanotic melanoma 10.5 MFN2 MFN1 FIS1 DNM1L AQP4
31 mitochondrial metabolism disease 10.5 POLG MT-ND6 MT-ND4
32 optic papillitis 10.5 MOG AQP4
33 cortical blindness 10.5 POLG MT-ND6 MT-ND4
34 optic atrophy 4 10.5 WFS1 OPA3 MT-ND6 MT-ND4
35 degeneration of macula and posterior pole 10.5 SERPINA3 ERCC6 CRYAA
36 optic atrophy 7 with or without auditory neuropathy 10.5 WFS1 OPA3 MT-ND6 MT-ND4
37 uveal disease 10.5 SERPINA3 CRYAA CCR6
38 teeth hard tissue disease 10.5 SERPINA3 ERCC6 CCR6
39 corneal disease 10.5 SERPINA3 ERCC6 CRYAA CCR6
40 amino acid metabolic disorder 10.5 SERPINA3 OPA3 CRYAA
41 x-linked recessive disease 10.5 SERPINA3 ERCC6 CRYAA CCR6
42 optic atrophy 8 10.5 WFS1 OPA3
43 testicular disease 10.5 SERPINA3 ERCC6 CCR6
44 lens disease 10.5 SERPINA3 OPA3 ERCC6 CRYAA
45 demyelinating disease 10.5 SERPINA3 MOG CCR6 AQP4
46 x-linked monogenic disease 10.5 SERPINA3 ERCC6 CRYAA CCR6
47 eye degenerative disease 10.5 SERPINA3 ERCC6 CRYAA CCR6
48 motor peripheral neuropathy 10.5 POLG MFN2 DCAF8
49 toxic optic neuropathy 10.5 OPA3 MT-ND6 MT-ND4 MFN2 AQP4
50 lymphangioma 10.5 SERPINA3 ERCC6 CCR6

Graphical network of the top 20 diseases related to Cranial Nerve Disease:



Diseases related to Cranial Nerve Disease

Symptoms & Phenotypes for Cranial Nerve Disease

UMLS symptoms related to Cranial Nerve Disease:


ophthalmoplegia; circumoral paresthesia

MGI Mouse Phenotypes related to Cranial Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 AQP4 CCR6 DCAF8 DNM1L ERCC6 FIS1
2 muscle MP:0005369 9.61 DNM1L ERCC6 FIS1 KIF21A MFN2 MOG
3 nervous system MP:0003631 9.36 AQP4 CCR6 DNM1L ERCC6 KIF21A MFN1

Drugs & Therapeutics for Cranial Nerve Disease

Drugs for Cranial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
3
Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
4
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
5
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
6
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
7
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
8
Cortisone Experimental Phase 1, Phase 2 53-06-5 222786
9 Gastrointestinal Agents Phase 1, Phase 2
10 Hormones Phase 1, Phase 2
11 Neuroprotective Agents Phase 1, Phase 2
12 Antiemetics Phase 1, Phase 2
13 Methylprednisolone Acetate Phase 1, Phase 2
14 Antineoplastic Agents, Hormonal Phase 1, Phase 2
15 Protective Agents Phase 1, Phase 2
16 Hormone Antagonists Phase 1, Phase 2
17 glucocorticoids Phase 1, Phase 2
18 Anti-Inflammatory Agents Phase 1, Phase 2
19 Hematinics Phase 2
20 Ferrosoferric Oxide Phase 2
21 Pharmaceutical Solutions Phase 2
22 Parenteral Nutrition Solutions Phase 2
23
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial and Data Registry Recruiting NCT04151082 Phase 1, Phase 2 Methylprednisolone;Prednisone
2 The Feasibility of Steady State CBV Mapping Using Ferumoxytol Immediately After Gadolinium Enhanced MRI of the CNS Recruiting NCT03270059 Phase 2 Ferumoxytol;Gadolinium
3 Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit Unknown status NCT03659760
4 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
5 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
6 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Completed NCT03206541
7 Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy Recruiting NCT02978911
8 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cranial Nerve Disease

Genetic Tests for Cranial Nerve Disease

Anatomical Context for Cranial Nerve Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cranial Nerve Disease:

19
One Of The Twelve Cranial Nerves

MalaCards organs/tissues related to Cranial Nerve Disease:

40
Olfactory Bulb, Pituitary, Eye, Bone, Spinal Cord, Pancreas, Skin

Publications for Cranial Nerve Disease

Articles related to Cranial Nerve Disease:

(show all 22)
# Title Authors PMID Year
1
Predicting postoperative delirium after microvascular decompression surgery with machine learning. 61
32504969 2020
2
Relationship of Inflammation With Trigeminal Neuralgia. 61
31609955 2020
3
Low Uric Acid Indicates Risk of Incidence of Trigeminal Neuralgia. 61
30939556 2019
4
[Application of complete endoscopic technique in microvascular decompression related tovertebrobasilar artery compression]. 61
31510719 2019
5
Effects of Depression and Anxiety on Microvascular Decompression Outcome for Trigeminal Neuralgia Patients. 61
31071444 2019
6
[CLINICAL STUDY OF INTEGRATED URINARY CARE TO SUPPORT SELF-RELIANCE AGAINST URINARY DYSFUNCTION WITH INVOLVEMENT BY UROLOGISTS]. 61
32684579 2019
7
MR Neurographic Evaluation of Facial and Neck Pain: Normal and Abnormal Craniospinal Nerves below the Skull Base. 61
30207933 2018
8
Usefulness of Totally Implantable Central Venous Access Devices in Elderly Patients: A Retrospective Study. 61
29353284 2018
9
Treatment of Posterior Inferior Cerebellar Artery Adhesion on Petrous Bone During Microvascular Decompression Procedure for Hemifacial Spasm: Technique Note. 61
28863115 2017
10
End-organ radiographic manifestations of cranial neuropathies: A concise review. 61
28364580 2017
11
[The Development of a Normal Database of Elderly People for Use with the Statistical Analysis Software Easy Z-score Imaging System with 99mTc-ECD SPECT]. 61
27263270 2015
12
Multiple synchronous sites of origin of vestibular schwannomas in neurofibromatosis Type 2. 61
26104281 2015
13
Clinical Characteristics and Treatment of Trigeminal Neuralgia Following Herpes Zoster. 61
26167998 2015
14
Advances in diagnosis and non-surgical treatment of Bell's palsy. 61
29937775 2015
15
[Clinicopathological study of acute esophageal mucosal lesion]. 61
23831655 2013
16
Gene expression changes in the olfactory bulb of mice induced by exposure to diesel exhaust are dependent on animal rearing environment. 61
23940539 2013
17
[Prognostic factors in patients undergoing percutaneous endoscopic gastrostomy]. 61
23925103 2013
18
[The normal cranial nerves in MRI. Description and visualization frequency]. 61
2056476 1991
19
Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198. 61
182313 1976
20
Inferior rectus palsies as a manifestation of atypical IIIrd cranial nerve disease. 61
1200458 1975
21
Cranial nerve disease. 61
4304044 1967
22
Ocular manifestations of cranial nerve disease. 61
13885420 1961

Variations for Cranial Nerve Disease

Expression for Cranial Nerve Disease

Search GEO for disease gene expression data for Cranial Nerve Disease.

Pathways for Cranial Nerve Disease

Pathways related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 MFN2 MFN1 FIS1

GO Terms for Cranial Nerve Disease

Cellular components related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 9.62 MIEF2 MFF FIS1 DNM1L
2 mitochondrial outer membrane GO:0005741 9.43 MIEF2 MFN2 MFN1 MFF FIS1 DNM1L
3 mitochondrion GO:0005739 9.36 POLG OPA3 MT-ND6 MT-ND4 MIEF2 MFN2
4 integral component of mitochondrial outer membrane GO:0031307 9.33 MFN1 MFF FIS1
5 intrinsic component of mitochondrial outer membrane GO:0031306 9.26 MFN2 MFN1

Biological processes related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein targeting to membrane GO:0090314 9.65 MIEF2 MFF FIS1
2 protein targeting to mitochondrion GO:0006626 9.63 MFN2 MFF FIS1
3 release of cytochrome c from mitochondria GO:0001836 9.61 MFF FIS1 DNM1L
4 mitochondrion morphogenesis GO:0070584 9.58 MFF FIS1 DNM1L
5 mitochondrial fission GO:0000266 9.54 MFF FIS1 DNM1L
6 mitochondrion localization GO:0051646 9.52 MFN2 MFN1
7 dynamin family protein polymerization involved in mitochondrial fission GO:0003374 9.51 MIEF2 DNM1L
8 peroxisome fission GO:0016559 9.5 MFF FIS1 DNM1L
9 regulation of peroxisome organization GO:1900063 9.49 MFF DNM1L
10 regulation of mitochondrion organization GO:0010821 9.46 MIEF2 MFF FIS1 DNM1L
11 mitochondrial fragmentation involved in apoptotic process GO:0043653 9.43 MFF FIS1 DNM1L
12 positive regulation of mitochondrial fission GO:0090141 9.26 MIEF2 MFF FIS1 DNM1L
13 mitochondrial fusion GO:0008053 9.02 MIEF2 MFN2 MFN1 MFF FIS1

Sources for Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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