MCID: CRN031
MIFTS: 41

Cranial Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Cranial Nerve Disease

MalaCards integrated aliases for Cranial Nerve Disease:

Name: Cranial Nerve Disease 12 15
Disorder of Cranial Nerve 12
Cranial Nerve Disorder 12
Cranial Nerve Diseases 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5656
ICD9CM 36 352.9
MeSH 45 D003389
NCIt 51 C26733
SNOMED-CT 69 73013002
ICD10 34 G52.9
UMLS 74 C0010266

Summaries for Cranial Nerve Disease

Disease Ontology : 12 A neuropathy that is located in one of the twelve cranial nerves.

MalaCards based summary : Cranial Nerve Disease, also known as disorder of cranial nerve, is related to third cranial nerve disease and optic nerve disease, and has symptoms including ophthalmoplegia and circumoral paresthesia. An important gene associated with Cranial Nerve Disease is AQP4 (Aquaporin 4). The drugs Ketamine and Ondansetron have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotype is growth/size/body region.

Wikipedia : 77 Cranial nerve disease is an impaired functioning of one of the twelve cranial nerves. Although it could... more...

Related Diseases for Cranial Nerve Disease

Diseases related to Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 third cranial nerve disease 34.0 KANTR MBP
2 optic nerve disease 30.5 ANTXR1 AQP4 MBP MFN2 MOG MT-ND1
3 glossopharyngeal nerve disease 11.7
4 cranial nerve palsy 11.7
5 abducens nerve disease 11.3
6 fibrosis of extraocular muscles, congenital, 2 10.4 KIF21A PHOX2A
7 glossopharyngeal neuralgia 10.4
8 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 10.4 OPA1 OPA3
9 behr syndrome 10.4 OPA1 OPA3
10 allergic encephalomyelitis 10.4 MBP MOG
11 scotoma 10.4 MT-ND4 OPA1
12 dissociated nystagmus 10.4 FRMD7 KANTR
13 central pontine myelinolysis 10.4 AQP4 MBP
14 leber optic atrophy 10.4 MT-ND1 MT-ND4 MT-ND6
15 leber optic atrophy and dystonia 10.4 MT-ND1 MT-ND4 MT-ND6
16 neuritis 10.4 AQP4 MBP MOG
17 balo concentric sclerosis 10.4 AQP4 MBP MOG
18 optic atrophy 1 10.4 MFN2 OPA1
19 myelitis 10.4 AQP4 MBP MOG
20 acute disseminated encephalomyelitis 10.4 AQP4 MBP MOG
21 autoimmune optic neuritis 10.4 AQP4 MBP MOG
22 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 10.4 MT-ND1 MT-ND4 MT-ND6
23 spinal cord disease 10.4 AQP4 MBP MOG
24 mitochondrial myopathy 10.4 MT-ND1 MT-ND4 MT-ND6
25 panencephalitis, subacute sclerosing 10.4 MBP MOG
26 neuromyelitis optica 10.4 AQP4 MBP MOG
27 lactic acidosis 10.4 MT-ND1 MT-ND4 MT-ND6
28 spastic paraplegia 7, autosomal recessive 10.4 MFN2 MT-ND4 OPA1
29 autoimmune disease of central nervous system 10.4 AQP4 MBP MOG
30 relapsing-remitting multiple sclerosis 10.4 AQP4 MBP MOG
31 mitochondrial encephalomyopathy 10.3 MT-ND1 MT-ND4 MT-ND6
32 exotropia 10.3 KIF21A PHOX2A
33 demyelinating disease 10.3 AQP4 MBP MOG
34 oculomotor nerve paralysis 10.3 KANTR MBP
35 immune system disease 10.3 AQP4 MBP MOG
36 neuroretinitis 10.3 AQP4 MOG UBL4A
37 alexia 10.3 AQP4 KANTR MBP
38 trigeminal nerve disease 10.3 LIPN MBD1
39 optic neuritis 10.3 AQP4 MBP MOG MT-ND4
40 paralytic squint 10.3 KANTR KIF21A PHOX2A
41 exposure keratitis 10.3 KANTR MT-ND4
42 tabes dorsalis 10.3 KANTR MBP
43 vagus nerve disease 10.3
44 hypoglossal nerve disease 10.3
45 multiple cranial nerve palsy 10.3
46 olfactory nerve disease 10.3
47 strabismus 10.3 FRMD7 KIF21A PHOX2A
48 ptosis 10.3 KIF21A OPA1 PHOX2A
49 acute retrobulbar neuritis 10.3 MBP MT-ND4 UBL4A
50 leber hereditary optic neuropathy 10.3 MT-ND1 MT-ND4 MT-ND6 OPA1

Graphical network of the top 20 diseases related to Cranial Nerve Disease:



Diseases related to Cranial Nerve Disease

Symptoms & Phenotypes for Cranial Nerve Disease

UMLS symptoms related to Cranial Nerve Disease:


ophthalmoplegia, circumoral paresthesia

MGI Mouse Phenotypes related to Cranial Nerve Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.36 ANTXR1 AQP4 MBP MFN2 MOG MT-ND6

Drugs & Therapeutics for Cranial Nerve Disease

Drugs for Cranial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 475)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
2
Ondansetron Approved Phase 4 99614-02-5 4595
3
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
4
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
5
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 53-03-2 5865
6
Mycophenolic acid Approved Phase 4 24280-93-1 446541
7
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 50-02-2 5743
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 1177-87-3
10
Bevacizumab Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 216974-75-3
11
4-Aminopyridine Approved Phase 4,Phase 2,Phase 3 504-24-5 1727
12
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
13
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
15
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
17
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
18
Povidone Approved Phase 4,Not Applicable 9003-39-8
19
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
20
Rimexolone Approved Phase 4 49697-38-3 39507
21
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
22
Fluorometholone Approved, Investigational Phase 4 426-13-1 9878
23
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
24
tannic acid Approved Phase 4,Phase 2,Phase 3,Not Applicable 1401-55-4
25
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
26
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
27
Carbidopa Approved Phase 4 28860-95-9 34359
28
Levodopa Approved Phase 4 59-92-7 6047
29
Brinzolamide Approved Phase 4 138890-62-7 68844
30
Ranibizumab Approved Phase 4,Phase 2,Phase 1 347396-82-1 459903
31
Gabapentin Approved, Investigational Phase 4,Phase 2,Not Applicable 60142-96-3 3446
32
Memantine Approved, Investigational Phase 4,Phase 2,Not Applicable 19982-08-2 4054
33
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
34
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
35
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
36
Idebenone Approved, Investigational Phase 4,Phase 3,Phase 2 58186-27-9
37
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
38
leucovorin Approved Phase 4,Early Phase 1 58-05-9 143 6006
39
Methotrexate Approved Phase 4,Early Phase 1 1959-05-2, 59-05-2 126941
40
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
41
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
42
Minocycline Approved, Investigational Phase 4,Phase 2 10118-90-8 5281021
43
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
44
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
45
Oxcarbazepine Approved Phase 4 28721-07-5 34312
46
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
47
Adenosine Approved, Investigational Phase 4 58-61-7 60961
48
Choline Approved, Nutraceutical Phase 4,Not Applicable 62-49-7 305
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2,Early Phase 1,Not Applicable 59-30-3 6037
50
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7

Interventional clinical trials:

(show top 50) (show all 747)
# Name Status NCT ID Phase Drugs
1 Postoperative Analgesia in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
2 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
3 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Unknown status NCT02379754 Phase 4 Gentamicins
4 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
5 The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia. Completed NCT03349515 Phase 4 Provodine-Iodine Solution;Group B will receive three drops in each eye of ophthalmic balanced salt solution.
6 Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery Completed NCT02816905 Phase 4 0.1 % Dexamethasone;0.1% Fluorometholone;1% Rimexolone
7 The Effect of Anaesthesia Depth on Oculo-cardiac Reflex Completed NCT02379546 Phase 4 Desflurane
8 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
9 Use of Bevacizumab in Trabeculectomy Surgery Completed NCT01166594 Phase 4 Bevacizumab;Control
10 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
11 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
12 Povidone-iodine Antisepsis for Strabismus Surgery Completed NCT00461656 Phase 4 Preoperative conjunctival irrigation with 5% or 1.25% PI
13 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
14 Topical Brinzolamide Ophthalmic Suspension Versus Placebo in the Treatment of Infantile Nystagmus Syndrome Completed NCT01312402 Phase 4 topical brinzolamide 1% in 5mL ophthalmic medication;Placebo in 5 mL dispenser
15 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
16 Treatment of Diabetic Macular Edema (DME) With Anti-VEGF and Focal Laser Completed NCT03590444 Phase 4 Ranibizumab 0.5 MG/0.05 ML Intraocular Solution
17 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
18 Treatment of Pendular Nystagmus in OPT Completed NCT02466191 Phase 4 Memantine;Gabapentin
19 Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery Completed NCT01901588 Phase 4 Dexmedetomidine
20 Effects of Dexmedetomidine Premedication on Emergence Agitation After Strabismus Surgery in Children Completed NCT01895023 Phase 4 Dexmedetomidine;Midazolam;Saline
21 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4 Macugen® pegaptanib sodium
22 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
23 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
24 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
25 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
26 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
27 Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
28 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
29 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
30 A Trial of Neuroprotection With ACTH in Acute Optic Neuritis Recruiting NCT01838174 Phase 4 ACTHAR Gel (ACTH);IV methylprednisolone (steroids)
31 Study to Assess the Efficacy and Safety of Raxone in LHON Patients Active, not recruiting NCT02774005 Phase 4 Idebenone
32 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
33 Pentoxifylline in Lupus Nephritis Not yet recruiting NCT03859570 Phase 4 Pentoxifylline;Placebos
34 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
35 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
36 Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event. Withdrawn NCT00037115 Phase 4 interferon beta 1a;methotrexate;methylprednisolone
37 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
38 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
39 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
40 Combination of Cisplatin Plus Gemcitabine Induction Chemotherapy and Intensity-modulated radiotherapyIntensity-modulated Radiotherapy With or Without Concurrent Cisplatin for NPC Unknown status NCT01854203 Phase 2, Phase 3 Inductive chemotherapy + concurrent cisplatin and IMRT;Inductive chemotherapy + IMRT
41 Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy Unknown status NCT02882477 Phase 2, Phase 3 Deferiprone;Acetylcysteine;Sitagliptin and Metformin
42 Convergence Insufficiency Treatment Trial (CITT) Unknown status NCT00338611 Phase 3
43 Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis Unknown status NCT02220244 Phase 3 MD1003 100mg capsule
44 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
45 Simvastatin Treatment of Patients With Acute Optic Neuritis Unknown status NCT00261326 Phase 3 simvastatin;placebo
46 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
47 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
48 Optic Neuritis Treatment Trial (ONTT) Unknown status NCT00000146 Phase 3 Methylprednisolone;Prednisone
49 Efficacy and Safety of GSK1358820 (Botulinum Toxin Type A) in Patients With Strabismus Completed NCT01584843 Phase 3 GSK1358820
50 Randomized Trial of Treatments for Convergence Insufficiency Completed NCT00347945 Phase 3

Search NIH Clinical Center for Cranial Nerve Disease

Genetic Tests for Cranial Nerve Disease

Anatomical Context for Cranial Nerve Disease

MalaCards organs/tissues related to Cranial Nerve Disease:

42
Brain, Eye, Testes, Bone, Lung, Kidney, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Cranial Nerve Disease:

20
One Of The Twelve Cranial Nerves

Publications for Cranial Nerve Disease

Articles related to Cranial Nerve Disease:

# Title Authors Year
1
Inferior rectus palsies as a manifestation of atypical IIIrd cranial nerve disease. ( 1200458 )
1975
2
Cranial nerve disease. ( 4304044 )
1967
3
Ocular manifestations of cranial nerve disease. ( 13885420 )
1961

Variations for Cranial Nerve Disease

Expression for Cranial Nerve Disease

Search GEO for disease gene expression data for Cranial Nerve Disease.

Pathways for Cranial Nerve Disease

GO Terms for Cranial Nerve Disease

Cellular components related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain GO:0070469 9.13 MT-ND1 MT-ND4 MT-ND6
2 mitochondrial membrane GO:0031966 8.92 MT-ND1 MT-ND4 MT-ND6 OPA1

Biological processes related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion morphogenesis GO:0070584 9.26 OPA1 OPA3
2 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.16 OPA1 WFS1
3 mitochondrial fusion GO:0008053 8.96 MFN2 OPA1
4 mitochondrial respiratory chain complex I assembly GO:0032981 8.8 MT-ND1 MT-ND4 MT-ND6

Molecular functions related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase activity GO:0003954 9.16 MT-ND1 MT-ND4
2 structural constituent of myelin sheath GO:0019911 8.96 MARVELD1 MBP
3 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.8 MT-ND1 MT-ND4 MT-ND6

Sources for Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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