Aliases & Classifications for Cranial Nerve Disease

MalaCards integrated aliases for Cranial Nerve Disease:

Name: Cranial Nerve Disease 12 15
Disorder of Cranial Nerve 12
Cranial Nerve Disorder 12
Cranial Nerve Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5656
ICD9CM 34 352.9
MeSH 43 D003389
NCIt 49 C26733
SNOMED-CT 67 73013002
ICD10 32 G52.8 G52.9 G53
UMLS 71 C0010266

Summaries for Cranial Nerve Disease

Disease Ontology : 12 A neuropathy that is located in one of the twelve cranial nerves.

MalaCards based summary : Cranial Nerve Disease, also known as disorder of cranial nerve, is related to abducens nerve disease and optic nerve disease, and has symptoms including ophthalmoplegia and circumoral paresthesia. An important gene associated with Cranial Nerve Disease is AQP4 (Aquaporin 4), and among its related pathways/superpathways is Mitophagy - animal. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include one of the twelve cranial nerves, bone and olfactory bulb, and related phenotype is nervous system.

Wikipedia : 74 Cranial nerve disease is an impaired functioning of one of the twelve cranial nerves. Although it could... more...

Related Diseases for Cranial Nerve Disease

Diseases related to Cranial Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 abducens nerve disease 33.0 MT-TK AQP4
2 optic nerve disease 31.7 WFS1 SERPINA3 OPA3 MT-TK MT-ND6 MT-ND4
3 neuritis 30.8 MT-ND4 MOG AQP4
4 acute retrobulbar neuritis 30.8 MT-ND4 CD40LG AQP4
5 guillain-barre syndrome 30.7 MOG CD40LG CCR6
6 muscular disease 30.7 SERPINA3 MT-TK ERCC6 CRYAA CCR6
7 third cranial nerve disease 12.4
8 glossopharyngeal nerve disease 12.1
9 cranial nerve palsy 11.5
10 combined oxidative phosphorylation deficiency 7 10.8 MT-ND4 MFN2 AQP4
11 optic atrophy 6 10.8 OPA3 MT-ND6 MT-ND4
12 autoimmune disease of eyes, ear, nose and throat 10.7 MOG CRYAA CCR6
13 nutritional optic neuropathy 10.7 OPA3 MT-ND4
14 vascular myelopathy 10.7 MOG AQP4
15 optic papillitis 10.7 MOG CD40LG AQP4
16 optic atrophy 8 10.7 WFS1 OPA3 MT-ND4
17 communicating hydrocephalus 10.7 SERPINA3 ERCC6 AQP4
18 drug-induced hearing loss 10.7 MT-TK MT-ND6 MT-ND4
19 leber optic atrophy and dystonia 10.7 MT-ND6 MT-ND4 MT-ND1
20 orbital disease 10.7 KIF21A ERCC6 CRYAA
21 pearson marrow-pancreas syndrome 10.7 MT-TK MT-ND6 MT-ND4
22 neuropathy, ataxia, and retinitis pigmentosa 10.7 MT-TK MT-ND6 MT-ND4
23 hereditary optic neuropathy 10.7 MT-ND6 MT-ND4 MT-ND1
24 optic atrophy 3, autosomal dominant 10.7 OPA3 MFN2 MFN1 CRYAA
25 optic atrophy 7 with or without auditory neuropathy 10.7 WFS1 OPA3 MT-ND6
26 toxic optic neuropathy 10.7 OPA3 MT-ND6 MT-ND4 AQP4
27 optic neuritis 10.7 MT-ND6 MT-ND4 MOG AQP4
28 deafness, aminoglycoside-induced 10.7 MT-TK MT-ND6 MT-ND4
29 central nervous system vasculitis 10.7 SERPINA3 CD40LG CCR6
30 mitochondrial dna depletion syndrome 4a 10.7 MT-TK MT-ND4 ERCC6
31 cortical blindness 10.7 MT-ND6 MT-ND4 MT-ND1
32 autoimmune disease of exocrine system 10.7 CD40LG CCR6 AQP4
33 fallopian tube disease 10.7 MFN2 CD40LG CCR6
34 cecal disease 10.7 SERPINA3 CD40LG CCR6
35 pyelitis 10.7 SERPINA3 CD40LG CCR6
36 hypersensitivity reaction type iii disease 10.7 SERPINA3 CD40LG CCR6
37 autoimmune disease of peripheral nervous system 10.7 MOG CD40LG CCR6 AQP4
38 acute disseminated encephalomyelitis 10.7 MOG CD40LG CCR6 AQP4
39 myelitis 10.7 MOG CD40LG CCR6 AQP4
40 electroclinical syndrome 10.7 MT-TK MT-ND4 CRYAA
41 optic atrophy 4 10.7 WFS1 OPA3 MT-ND6 MT-ND4
42 plasma protein metabolism disease 10.7 SERPINA3 CD40LG CCR6
43 spinal cord disease 10.7 MOG CD40LG CCR6 AQP4
44 autoimmune disease of blood 10.7 SERPINA3 CD40LG CCR6
45 panuveitis 10.7 SERPINA3 CD40LG CCR6
46 gastric squamous cell carcinoma 10.7 SERPINA3 CCR6
47 middle ear disease 10.7 SERPINA3 CD40LG CCR6
48 balo concentric sclerosis 10.7 MOG AQP4
49 corneal disease 10.7 SERPINA3 ERCC6 CRYAA CCR6
50 viral encephalitis 10.7 MOG CD40LG CCR6

Graphical network of the top 20 diseases related to Cranial Nerve Disease:



Diseases related to Cranial Nerve Disease

Symptoms & Phenotypes for Cranial Nerve Disease

UMLS symptoms related to Cranial Nerve Disease:


ophthalmoplegia, circumoral paresthesia

MGI Mouse Phenotypes related to Cranial Nerve Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.36 AQP4 CCR6 CD40LG DNM1L ERCC6 KIF21A

Drugs & Therapeutics for Cranial Nerve Disease

Drugs for Cranial Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
3
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
4
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
5
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
6 Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
7
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
8
Cortisone Experimental Phase 1, Phase 2 53-06-5 222786
9 Antineoplastic Agents, Hormonal Phase 1, Phase 2
10 Hormones Phase 1, Phase 2
11 Methylprednisolone Acetate Phase 1, Phase 2
12 Hormone Antagonists Phase 1, Phase 2
13 Neuroprotective Agents Phase 1, Phase 2
14 glucocorticoids Phase 1, Phase 2
15 Antiemetics Phase 1, Phase 2
16 Protective Agents Phase 1, Phase 2
17 Gastrointestinal Agents Phase 1, Phase 2
18 Anti-Inflammatory Agents Phase 1, Phase 2
19 Ferrosoferric Oxide Phase 2
20 Parenteral Nutrition Solutions Phase 2
21 Hematinics Phase 2
22 Pharmaceutical Solutions Phase 2
23
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial Recruiting NCT04151082 Phase 1, Phase 2 Methylprednisolone;Prednisone
2 The Feasibility of Steady State CBV Mapping Using Ferumoxytol Immediately After Gadolinium Enhanced MRI of the CNS Recruiting NCT03270059 Phase 2 Ferumoxytol;Gadolinium
3 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
4 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
5 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Completed NCT03206541
6 Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit Recruiting NCT03659760
7 Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy Recruiting NCT02978911
8 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cranial Nerve Disease

Genetic Tests for Cranial Nerve Disease

Anatomical Context for Cranial Nerve Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cranial Nerve Disease:

19
One Of The Twelve Cranial Nerves

MalaCards organs/tissues related to Cranial Nerve Disease:

40
Bone, Olfactory Bulb, Pituitary

Publications for Cranial Nerve Disease

Articles related to Cranial Nerve Disease:

(show all 21)
# Title Authors PMID Year
1
Predicting postoperative delirium after microvascular decompression surgery with machine learning. 61
32504969 2020
2
Relationship of Inflammation With Trigeminal Neuralgia. 61
31609955 2020
3
Low Uric Acid Indicates Risk of Incidence of Trigeminal Neuralgia. 61
30939556 2019
4
[Application of complete endoscopic technique in microvascular decompression related tovertebrobasilar artery compression]. 61
31510719 2019
5
Effects of Depression and Anxiety on Microvascular Decompression Outcome for Trigeminal Neuralgia Patients. 61
31071444 2019
6
MR Neurographic Evaluation of Facial and Neck Pain: Normal and Abnormal Craniospinal Nerves below the Skull Base. 61
30207933 2018
7
Usefulness of Totally Implantable Central Venous Access Devices in Elderly Patients: A Retrospective Study. 61
29353284 2018
8
Treatment of Posterior Inferior Cerebellar Artery Adhesion on Petrous Bone During Microvascular Decompression Procedure for Hemifacial Spasm: Technique Note. 61
28863115 2017
9
End-organ radiographic manifestations of cranial neuropathies: A concise review. 61
28364580 2017
10
[The Development of a Normal Database of Elderly People for Use with the Statistical Analysis Software Easy Z-score Imaging System with 99mTc-ECD SPECT]. 61
27263270 2015
11
Multiple synchronous sites of origin of vestibular schwannomas in neurofibromatosis Type 2. 61
26104281 2015
12
Clinical Characteristics and Treatment of Trigeminal Neuralgia Following Herpes Zoster. 61
26167998 2015
13
Advances in diagnosis and non-surgical treatment of Bell's palsy. 61
29937775 2015
14
[Clinicopathological study of acute esophageal mucosal lesion]. 61
23831655 2013
15
[Prognostic factors in patients undergoing percutaneous endoscopic gastrostomy]. 61
23925103 2013
16
Gene expression changes in the olfactory bulb of mice induced by exposure to diesel exhaust are dependent on animal rearing environment. 61
23940539 2013
17
[The normal cranial nerves in MRI. Description and visualization frequency]. 61
2056476 1991
18
Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198. 61
182313 1976
19
Inferior rectus palsies as a manifestation of atypical IIIrd cranial nerve disease. 61
1200458 1975
20
Cranial nerve disease. 61
4304044 1967
21
Ocular manifestations of cranial nerve disease. 61
13885420 1961

Variations for Cranial Nerve Disease

Expression for Cranial Nerve Disease

Search GEO for disease gene expression data for Cranial Nerve Disease.

Pathways for Cranial Nerve Disease

Pathways related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 MFN2 MFN1 FIS1

GO Terms for Cranial Nerve Disease

Cellular components related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.25 WFS1 MT-ND6 MT-ND4 MT-ND1 MOG MIEF2
2 mitochondrial membrane GO:0031966 9.67 MT-ND6 MT-ND4 MT-ND1 DNM1L
3 mitochondrion GO:0005739 9.65 OPA3 MT-ND6 MT-ND4 MT-ND1 MIEF2 MFN2
4 peroxisome GO:0005777 9.62 MIEF2 MFF FIS1 DNM1L
5 respiratory chain GO:0070469 9.58 MT-ND6 MT-ND4 MT-ND1
6 integral component of mitochondrial outer membrane GO:0031307 9.33 MFN1 MFF FIS1
7 intrinsic component of mitochondrial outer membrane GO:0031306 9.26 MFN2 MFN1
8 mitochondrial outer membrane GO:0005741 9.1 MIEF2 MFN2 MFN1 MFF FIS1 DNM1L

Biological processes related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex I assembly GO:0032981 9.73 MT-ND6 MT-ND4 MT-ND1
2 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.72 MT-ND6 MT-ND4 MT-ND1
3 positive regulation of protein targeting to membrane GO:0090314 9.69 MIEF2 MFF FIS1
4 protein targeting to mitochondrion GO:0006626 9.67 MFN2 MFF FIS1
5 release of cytochrome c from mitochondria GO:0001836 9.61 MFF FIS1 DNM1L
6 cellular response to lipid GO:0071396 9.58 FIS1 DNM1L
7 mitochondrion localization GO:0051646 9.58 MFN2 MFN1
8 mitochondrial fission GO:0000266 9.58 MFF FIS1 DNM1L
9 dynamin family protein polymerization involved in mitochondrial fission GO:0003374 9.57 MIEF2 DNM1L
10 mitochondrion morphogenesis GO:0070584 9.56 OPA3 MFF FIS1 DNM1L
11 response to hypobaric hypoxia GO:1990910 9.54 FIS1 DNM1L
12 peroxisome fission GO:0016559 9.54 MFF FIS1 DNM1L
13 regulation of peroxisome organization GO:1900063 9.52 MFF DNM1L
14 mitochondrial fragmentation involved in apoptotic process GO:0043653 9.5 MFF FIS1 DNM1L
15 response to flavonoid GO:1905395 9.48 FIS1 DNM1L
16 cellular response to thapsigargin GO:1904579 9.46 FIS1 DNM1L
17 regulation of mitochondrion organization GO:0010821 9.46 MIEF2 MFF FIS1 DNM1L
18 positive regulation of mitochondrial fission GO:0090141 9.26 MIEF2 MFF FIS1 DNM1L
19 mitochondrial fusion GO:0008053 9.02 MIEF2 MFN2 MFN1 MFF FIS1

Molecular functions related to Cranial Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase activity GO:0003954 8.96 MT-ND4 MT-ND1
2 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.8 MT-ND6 MT-ND4 MT-ND1

Sources for Cranial Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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