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MCID: CRN035
MIFTS: 42

Cranial Nerve Palsy

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cranial Nerve Palsy

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MalaCards integrated aliases for Cranial Nerve Palsy:

Name: Cranial Nerve Palsy 12 15 17
Cranial Nerve Paralysis 12 29
Cranial Nerve Diseases 44 72
Cranial Nerve Palsies 72

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3817
MeSH 44 D003389
NCIt 50 C26941
SNOMED-CT 68 73013002
UMLS 72 C0010266 C0151311
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Summaries for Cranial Nerve Palsy

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MalaCards based summary : Cranial Nerve Palsy, also known as cranial nerve paralysis, is related to lyme disease and fourth cranial nerve palsy, familial congenital, and has symptoms including ophthalmoplegia, circumoral paresthesia and neurologic symptoms. An important gene associated with Cranial Nerve Palsy is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Pyrimethamine and Sulfadiazine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and bone, and related phenotype is integument.

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Related Diseases for Cranial Nerve Palsy

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Diseases in the Cranial Nerve Palsy family:

Multiple Cranial Nerve Palsy

Diseases related to Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 lyme disease 29.5 CRP CD40LG
2 fourth cranial nerve palsy, familial congenital 12.9
3 fourth cranial nerve palsy 12.8
4 cranial nerve disease 12.8
5 multiple cranial nerve palsy 12.7
6 third cranial nerve disease 12.4
7 glossopharyngeal nerve disease 12.1
8 abducens nerve disease 11.8
9 congenital oculomotor nerve palsy 11.8
10 congenital trochlear nerve palsy 11.8
11 neurosarcoidosis 11.7
12 diabetic neuropathy 11.6
13 congenital abducens nerve palsy 11.5
14 brown-vialetto-van laere syndrome 1 11.5
15 behcet syndrome 11.3
16 cowden syndrome 1 11.3
17 osteopetrosis, autosomal dominant 2 11.3
18 paraganglioma and gastric stromal sarcoma 11.3
19 eastern equine encephalitis 11.3
20 mollaret meningitis 11.3
21 glomus vagale tumor 11.3
22 ptosis 10.6
23 dysphagia 10.6
24 aneurysm 10.6
25 kearns-sayre syndrome 10.5
26 facial paralysis 10.5
27 meningitis 10.5
28 neuropathy 10.5
29 strabismus 10.5
30 mechanical strabismus 10.5
31 carotid artery dissection 10.4
32 nasopharyngeal carcinoma 10.4
33 headache 10.4
34 ataxia and polyneuropathy, adult-onset 10.4
35 vasculitis 10.4
36 hydrocephalus 10.4
37 pituitary apoplexy 10.4
38 congenital hydrocephalus 10.4
39 branchiootic syndrome 1 10.4
40 intracranial hypotension 10.4
41 herpes zoster 10.4
42 intracranial hypertension 10.3
43 pituitary tumors 10.3
44 skull base cancer 10.3 NT5C3A CCDC174
45 skull base meningioma 10.3 NT5C3A CCDC174
46 sarcoidosis 1 10.3
47 monocular esotropia 10.3
48 exophthalmos 10.3
49 esotropia 10.3
50 myeloma, multiple 10.3

Comorbidity relations with Cranial Nerve Palsy via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Cranial Nerve Palsy:



Diseases related to Cranial Nerve Palsy
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Symptoms & Phenotypes for Cranial Nerve Palsy

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UMLS symptoms related to Cranial Nerve Palsy:


ophthalmoplegia, circumoral paresthesia, neurologic symptoms

MGI Mouse Phenotypes related to Cranial Nerve Palsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 APC CD40LG POMC SLC52A2 SLC52A3
Sources

Drugs & Therapeutics for Cranial Nerve Palsy

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Drugs for Cranial Nerve Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
2
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
5 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
6 Antiparasitic Agents Phase 4
7 Antiprotozoal Agents Phase 4
8 Antimalarials Phase 4
9
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
10
Cabergoline Approved Phase 3 81409-90-7 54746
11
Lenograstim Approved, Investigational Phase 3 135968-09-1
12
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
13
Daunorubicin Approved Phase 3 20830-81-3 30323
14
Sargramostim Approved, Investigational Phase 3 83869-56-1, 123774-72-1
15
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
16
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
17
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
18
leucovorin Approved Phase 3 58-05-9 143 6006
19
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
20
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
21
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
22
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
23
Etoposide Approved Phase 3 33419-42-0 36462
24
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
25
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
26
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
27
Mercaptopurine Approved Phase 3 50-44-2 667490
28
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
29
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
30
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
31
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
32
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
33
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
34
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
35
Pegaspargase Approved, Investigational Phase 3 130167-69-0
36
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
37
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
38
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
39 Dopamine Agents Phase 3
40 Dopamine agonists Phase 3
41 Neurotransmitter Agents Phase 3
42 Antiparkinson Agents Phase 3
43 Analgesics Phase 3
44 Adjuvants, Immunologic Phase 3
45 topoisomerase I inhibitors Phase 3
46 HIV Protease Inhibitors Phase 3
47
protease inhibitors Phase 3
48 Folic Acid Antagonists Phase 3
49 Anti-Infective Agents Phase 3
50 Folate Phase 3

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Pyrimethamine Plus Sulfadiazine Versus Trimethoprim Plus Sulfamethoxazole for Treatment of Toxoplasmic Encephalitis in AIDS Patients: A Randomized Controlled Trial. Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
2 Dopamine Agonist Cabergoline in Residual Clinically Nonfunctioning Pituitary Adenoma After Transphenoidal Surgery: A Single Center, Open Label and Randomized Clinical Trial Completed NCT03271918 Phase 3 Cabergoline
3 Randomized Study of Vincristine, Actinomycin-D, and Cyclophosphamide (VAC) Versus VAC Alternating With Vincristine, Topotecan and Cyclophosphamide for Patients With Intermediate Risk Rhabdomyosarcoma Completed NCT00003958 Phase 3 vincristine sulfate;cyclophosphamide;topotecan hydrochloride
4 A RANDOMIZED PHASE III TRIAL COMPARING DEXAMETHASONE WITH PREDNISONE IN INDUCTION TREATMENT AND BONE MARROW TRANSPLANTATION WITH INTENSIVE MAINTENANCE TREATMENT IN ADOLESCENT AND ADULT ACUTE LYMPHOBLASTIC LEUKEMIA (ALL-4) Completed NCT00002700 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
5 FAB LMB 96 -- Treatment of Mature B-CELL Lymphoma/Leukemia: A SFOP LMB 96/CCG 5961/UKCCSG NHL 9600 Cooperative Study Completed NCT00002757 Phase 3 cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;methotrexate;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
6 Treatment of Acute Lymphoblastic Leukemia in Children Active, not recruiting NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
7 A Multi-Center, Randomized Controlled Study Trial to Investigate the Effect of Varying Volumes of Blood Patch on the Resolution of Postdural Puncture Headache (PDPH) Terminated NCT00373074 Phase 2, Phase 3
8 A Clinicopathological Study In Burkitts's And Burkitt-Like Non-Hodgkin's Lymphoma Completed NCT00040690 Phase 2 cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate
9 PILOT MULTINATIONAL PROTOCOLS IN ACUTE LYMPHOBLASTIC LEUKEMIA AND DIFFUSE NON-HODGKIN'S LYMPHOMA Completed NCT00018954 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;vincristine sulfate
10 TREATMENT OF ISOLATED CNS RELAPSE OF ACUTE LYMPHOBLASTIC LEUKEMIA -- A PEDIATRIC ONCOLOGY GROUP-WIDE PHASE II STUDY Completed NCT00002704 Phase 2 asparaginase;cyclophosphamide;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;liposomal cytarabine;mercaptopurine;mesna;methotrexate;therapeutic hydrocortisone;thiotepa;vincristine sulfate
11 The Feasibility of Steady State CBV Mapping Using Ferumoxytol Immediately After Gadolinium Enhanced MRI of the CNS Recruiting NCT03270059 Phase 2 Ferumoxytol;Gadolinium
12 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
13 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
14 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070
15 Predictive Factors of Re-craniotomy and Major Non-neurological Complications in Elective Neurosurgery: A Prospective Cohort Study Completed NCT03910556 Propofol
16 Phase IV Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
17 Treatment for Newly Diagnosed Patients With Stage III/IV Non-Hodgkin Lymphoma-Study XIII (A Therapeutic Pilot Study) Completed NCT00187122 Vincristine;Daunomycin;L-Asparaginase;Cytarabine;Methotrexate;Mercaptopurine;Etoposide;Cyclophosphamide;Prednisone;Dexamethasone
18 Incidence of Post-Dural Puncture Headache Following Unintentional Dural Puncture: A Randomized Trial of Intrathecal Morphine Versus Saline Completed NCT01977898 Morphine;Saline
19 Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy Recruiting NCT02978911
20 Routine Care Study Evaluating Ocular Torsion Recruiting NCT02894411
21 Correlation Between Cerebral Microembolisation and Plaque Characteristics After Carotid Revascularization Recruiting NCT03303430
22 Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit Recruiting NCT03659760
23 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Recruiting NCT03206541
24 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cranial Nerve Palsy

Cochrane evidence based reviews: cranial nerve diseases

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Genetic Tests for Cranial Nerve Palsy

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Genetic tests related to Cranial Nerve Palsy:

# Genetic test Affiliating Genes
1 Cranial Nerve Paralysis 29
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Anatomical Context for Cranial Nerve Palsy

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MalaCards organs/tissues related to Cranial Nerve Palsy:

41
Pituitary, Brain, Bone, Prostate, Eye, Bone Marrow, B Cells
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Publications for Cranial Nerve Palsy

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Articles related to Cranial Nerve Palsy:

(show top 50) (show all 1616)
# Title Authors PMID Year
1
Making Microguidewire Loop Facilitates Navigation Through Tortuous or Abruptly Angulated Head and Neck Veins to Access Cavernous Sinus Dural Arteriovenous Fistulas. 38
31158531 2019
2
Relationship of clinical presentation and angiographic findings in patients with indirect cavernous carotid fistulae. 38
30777891 2019
3
Clinical characteristics of tuberculous meningitis combined with cranial nerve palsy. 38
31336359 2019
4
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 38
31097370 2019
5
Recurrent and Progressive Facial Baroparesis on Flying Relieved by Eustachian Tube Dilation. 38
30895801 2019
6
Implication of the inferolateral trunk of the cavernous internal CAROTID artery in cranial nerve blood supply: Anatomical study and review of the literature. 38
31330308 2019
7
Nishida procedure associated with botulinum toxin in a long-standing complete bilateral sixth cranial nerve palsy. 38
31326157 2019
8
Cranial nerve palsy: an unusual presentation of a fulminant fungal disease. 38
31305937 2019
9
Pituitary Apoplexy: Results of Surgical and Conservative Management Clinical Series and Review of the Literature. 38
31302273 2019
10
Idiopathic third and sixth cranial nerve neuritis. 38
31006061 2019
11
Botulinum toxin A in the early treatment of sixth nerve palsy in type 2 diabetes. 38
31238428 2019
12
Postoperative Correction and Drift After Vertical Rectus Muscle Transposition for Total Sixth Cranial Nerve Palsy. 38
31322714 2019
13
A case of bilateral fourth nerve palsy associated with pseudotumor cerebri syndrome. 38
31038553 2019
14
Radiofrequency Ablation of Facial Venolymphatic Malformations: Assessment of Efficacy and Safety and the Role of Injectable Electrodes. 38
31235409 2019
15
Strategy and technique of endonasal endoscopic bony decompression and selective tumor removal in symptomatic skull base meningiomas of the cavernous sinus and Meckel's cave. 38
31226453 2019
16
Hypertrophic chronic pachymeningitis associated with Epstein-Barr virus reactivation: a case report. 38
30747332 2019
17
Treatment of an aberrant inferior temporal artery aneurysm arising off the proximal cavernous segment of the internal carotid artery. 38
31164005 2019
18
Isolated Trochlear Nerve Palsy in a Patient with Superior Cerebellar Rete Mirabile. 38
31181360 2019
19
Extensive intracranial haemorrhage as a complication of acute lymphoblastic leukaemia with hyperleukocytosis. 38
30948308 2019
20
Role of Oxidative Stress in Tuberculous Meningitis: a Clinico-Radiological Correlation. 38
30976988 2019
21
Progressive sixth nerve palsy secondary to intracavernous arachnoid cyst and complicated by contralateral optic nerve sheath meningioma. 38
31155935 2019
22
Acquired onset of third, fourth, and sixth cranial nerve palsies in children and adolescents. 38
30760897 2019
23
Clinical and genetic heterogeneity in Melkersson-Rosenthal Syndrome. 38
30217753 2019
24
Brain Aneurysms in the Pediatric Population of Slovenia: A Case Series. 38
30630214 2019
25
Neurological and Ophthalmological Manifestations of Varicella Zoster Virus. 38
30188405 2019
26
Microsurgical Management of Trigeminal Schwannoma: Cohort Analysis and Systematic Review. 38
31143569 2019
27
Newly occurring cranial nerve palsy after endovascular treatment of cavernous sinus dural arteriovenous fistulas. 38
31048455 2019
28
A 10-year-old female with unilateral seventh cranial nerve palsy. 38
30996593 2019
29
Adjuvant Radiation Therapy Compared with Observation Alone for Postoperative Residual Nonfunctional Pituitary Adenomas. 38
31103758 2019
30
Diplopia: a unique presentation of recurrence of a salivary gland carcinoma. 38
31061174 2019
31
Suprasellar epidermoid cyst: case report of extended endoscopic transsphenoidal resection and systematic review of the literature. 38
31121364 2019
32
Spontaneous persistent primitive trigeminal artery-cavernous sinus fistula successfully treated by multipronged coil embolization: A case report and literature review. 38
31078800 2019
33
Sixth cranial nerve palsy and ipsilateral segmental carotid arteritis after tooth alveolectomy. 38
30982133 2019
34
Cervical artery dissection: fibromuscular dysplasia versus vascular Ehlers-Danlos syndrome. 38
30623691 2019
35
Fungal Malignant Otitis Externa Involves a Cascade of Complications Culminating in Pseudoaneurysm of Internal Maxillary Artery: A Case Report. 38
31005959 2019
36
Ocular Misalignment in Dizzy Patients-Something's A-Skew. 38
30883490 2019
37
A Retrospective Study in Microsurgical Procedures of Large and Giant Intracranial Aneurysms: An Outcome Analysis. 38
31218282 2019
38
Pupil-sparing third cranial nerve palsy with aberrant regeneration secondary to cavernous sinus arachnoid cyst. 38
30555949 2019
39
A risk-benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: a comprehensive review. 38
30889367 2019
40
Carotid Endarterectomy for Medical Therapy-Resistant Symptomatic Low-Grade Stenosis. 38
30521960 2019
41
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features. 38
30225516 2019
42
Skull base osteomyelitis: factors implicating clinical outcome. 38
30840222 2019
43
Delayed diagnosis of odontoid peg osteomyelitis with bilateral X and XII cranial nerve palsies. 38
30936340 2019
44
Clinical characteristics and complications of skull base osteomyelitis: A 12-year study in a teaching hospital in South India. 38
31041210 2019
45
Ophthalmologic Clinical Features of Facial Nerve Palsy Patients. 38
30746906 2019
46
Neurological Involvement in Childhood Evans Syndrome. 38
30671780 2019
47
Relapsing Long-Lasting Garcin Syndrome Revealing Skull Base Diffuse B Cell Lymphoma: The Diagnosis through the "Hartel's Route". 38
30733909 2019
48
Neurosyphilis presenting as cranial nerve palsy, an entity which is easy to miss. 38
30796075 2019
49
Transcaruncular rectus tendon fixation to the orbit and frontalis flap for complete third nerve palsy. 38
29543543 2019
50
Comparative Analysis Using Propensity Score Matching Analysis: Primary Closure Versus Patch Angioplasty During Carotid Endarterectomy. 38
30763710 2019
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Variations for Cranial Nerve Palsy

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Expression for Cranial Nerve Palsy

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Search GEO for disease gene expression data for Cranial Nerve Palsy.
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Pathways for Cranial Nerve Palsy

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Pathways related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metabolism of water-soluble vitamins and cofactors 66
Show member pathways
 11.74 SLC52A3 SLC52A2 SLC52A1
2
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.1 POMC CRP
Sources

GO Terms for Cranial Nerve Palsy

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Biological processes related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 riboflavin metabolic process GO:0006771 9.13 SLC52A3 SLC52A2 SLC52A1
2 riboflavin transport GO:0032218 8.8 SLC52A3 SLC52A2 SLC52A1

Molecular functions related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.96 SLC52A2 SLC52A1
2 riboflavin transmembrane transporter activity GO:0032217 8.8 SLC52A3 SLC52A2 SLC52A1
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Sources for Cranial Nerve Palsy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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