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MCID: CRN035
MIFTS: 40

Cranial Nerve Palsy

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cranial Nerve Palsy

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MalaCards integrated aliases for Cranial Nerve Palsy:

Name: Cranial Nerve Palsy 12 15 17
Cranial Nerve Paralysis 12 30
Cranial Nerve Diseases 45 74
Cranial Nerve Palsies 74

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:3817
MeSH 45 D003389
NCIt 51 C26941
SNOMED-CT 69 73013002
ICD10 34 G52.8 G53
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Summaries for Cranial Nerve Palsy

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MalaCards based summary : Cranial Nerve Palsy, also known as cranial nerve paralysis, is related to exophthalmos and sphenoid sinusitis, and has symptoms including ophthalmoplegia, circumoral paresthesia and neurologic symptoms. An important gene associated with Cranial Nerve Palsy is APC (APC Regulator Of WNT Signaling Pathway). The drugs leucovorin and Pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and b cells.

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Related Diseases for Cranial Nerve Palsy

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Diseases in the Cranial Nerve Palsy family:

Multiple Cranial Nerve Palsy

Diseases related to Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 30.1 RHNO1 SCYL1
2 sphenoid sinusitis 29.9 KANTR RHNO1 SLC25A16
3 branch retinal artery occlusion 29.8 KANTR RHNO1
4 fourth cranial nerve palsy, familial congenital 12.7
5 fourth cranial nerve palsy 12.7
6 multiple cranial nerve palsy 12.6
7 cranial nerve disease 12.6
8 third cranial nerve disease 12.3
9 glossopharyngeal nerve disease 11.7
10 oculomotor nerve paralysis 11.7
11 congenital oculomotor nerve palsy 11.7
12 congenital trochlear nerve palsy 11.7
13 neurosarcoidosis 11.5
14 bell's palsy 11.4
15 abducens nerve disease 11.4
16 congenital abducens nerve palsy 11.4
17 brown-vialetto-van laere syndrome 1 11.4
18 behcet syndrome 11.2
19 cowden syndrome 1 11.2
20 osteopetrosis, autosomal dominant 2 11.2
21 paraganglioma and gastric stromal sarcoma 11.2
22 diabetic neuropathy 11.2
23 eastern equine encephalitis 11.2
24 mollaret meningitis 11.2
25 tolosa-hunt syndrome 11.2
26 glomus vagale tumor 11.2
27 lymphoma 10.4
28 meningitis 10.4
29 nasopharyngeal carcinoma 10.4
30 carotid artery dissection 10.4
31 pituitary apoplexy 10.3
32 neuropathy 10.3
33 prostate cancer 10.2
34 leukemia 10.2
35 intracranial hypotension 10.2
36 arachnoid cysts 10.2
37 systemic lupus erythematosus 10.2
38 herpes zoster 10.2
39 lupus erythematosus 10.2
40 intracranial sinus thrombosis 10.2 NT5C3A RHNO1
41 cavernous sinus thrombosis 10.2 NT5C3A RHNO1
42 poliomyelitis 10.1
43 pfeiffer syndrome 10.1
44 burkitt lymphoma 10.1
45 strabismus 10.1
46 trigeminal neuralgia 10.1
47 myeloma, multiple 10.1
48 prostate cancer, hereditary, 8 10.1
49 granulomatosis with polyangiitis 10.1
50 prostate cancer, hereditary, 6 10.1

Comorbidity relations with Cranial Nerve Palsy via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Cranial Nerve Palsy:



Diseases related to Cranial Nerve Palsy
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Symptoms & Phenotypes for Cranial Nerve Palsy

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UMLS symptoms related to Cranial Nerve Palsy:


ophthalmoplegia, circumoral paresthesia, neurologic symptoms
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Drugs & Therapeutics for Cranial Nerve Palsy

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Drugs for Cranial Nerve Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 2,Phase 3 58-05-9 143 6006
2
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
5
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
7 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
8 Anti-Infective Agents Phase 4,Phase 2,Phase 3
9 Vitamin B9 Phase 4,Phase 2,Phase 3
10 Vitamin B Complex Phase 4,Phase 2,Phase 3
11 Antiparasitic Agents Phase 4,Phase 2
12 Folate Phase 4,Phase 2,Phase 3
13 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
14 Folic Acid Antagonists Phase 4
15 Antimalarials Phase 4
16 Antiprotozoal Agents Phase 4,Phase 2
17
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
18
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
19
Cytarabine Approved, Experimental, Investigational Phase 2, Phase 3 147-94-4, 65-46-3 6253
20
Rasburicase Approved, Investigational Phase 2, Phase 3 134774-45-1
21
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
22
Vincristine Approved, Investigational Phase 2, Phase 3 2068-78-2, 57-22-7 5978
23
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
24
rituximab Approved Phase 2, Phase 3 174722-31-7 10201696
25
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
26
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
27
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
28
Doxil Approved June 1999 Phase 2, Phase 3 31703
29 Antimetabolites Phase 2, Phase 3
30 Trace Elements Phase 2, Phase 3
31 Adjuvants, Immunologic Phase 2, Phase 3
32 Antineoplastic Agents, Alkylating Phase 2, Phase 3
33 Alkylating Agents Phase 2, Phase 3
34 Antineoplastic Agents, Immunological Phase 2, Phase 3
35 Antidotes Phase 2, Phase 3
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
37 Hematinics Phase 2, Phase 3
38 Hormones Phase 2, Phase 3
39 Nutrients Phase 2, Phase 3
40 glucocorticoids Phase 2, Phase 3
41 Antiviral Agents Phase 2, Phase 3
42 Immunologic Factors Phase 2, Phase 3
43 Topoisomerase Inhibitors Phase 2, Phase 3
44 Vitamins Phase 2, Phase 3
45 Etoposide phosphate Phase 2, Phase 3
46 Protective Agents Phase 2, Phase 3
47 Antirheumatic Agents Phase 2, Phase 3
48 Antibiotics, Antitubercular Phase 2, Phase 3
49 Immunosuppressive Agents Phase 2, Phase 3
50 Hormone Antagonists Phase 2, Phase 3

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
2 EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
3 Mature B-Cell Lymphoma And Leukemia Study III Recruiting NCT01046825 Phase 2, Phase 3 COPAD;COP, COPD M3, CYM;COP, COPADM8, CYVE
4 " Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " Not yet recruiting NCT02841098 Phase 3 Optimal medical therapy alone
5 Treatment for Advanced B-Cell Lymphoma Recruiting NCT01859819 Phase 2 Rituximab;IT Cytarabine
6 Treatment With Tamoxifen in Cryptococcal Meningitis Active, not recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
7 Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage Withdrawn NCT02165644 Phase 2 Acetazolamide;Nimodipine
8 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
9 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070 Not Applicable
10 Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage Completed NCT03214705
11 Cranial Nerves Tractography Recruiting NCT02978911 Not Applicable
12 Microembolisation After Carotid Revascularisation Recruiting NCT03303430
13 Reclaimâ„¢ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (OCD) Recruiting NCT02773082 Not Applicable
14 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
15 Improving Infant Hydrocephalus Outcomes in Uganda Not yet recruiting NCT03650101
16 Mid-term Data Collection of the Treatment of Intracranial Aneurysms With the WEBâ„¢ Aneurysm Embolization System Withdrawn NCT03379714

Search NIH Clinical Center for Cranial Nerve Palsy

Cochrane evidence based reviews: cranial nerve diseases

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Genetic Tests for Cranial Nerve Palsy

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Genetic tests related to Cranial Nerve Palsy:

# Genetic test Affiliating Genes
1 Cranial Nerve Paralysis 30
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Anatomical Context for Cranial Nerve Palsy

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MalaCards organs/tissues related to Cranial Nerve Palsy:

42
Pituitary, Bone, B Cells, Brain, Prostate, Myeloid, Tonsil
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Publications for Cranial Nerve Palsy

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Articles related to Cranial Nerve Palsy:

(show top 50) (show all 284)
# Title Authors Year
1
A case of acute respiratory distress syndrome with sixth cranial nerve palsy. ( 30032429 )
2019
2
Pupil-sparing third cranial nerve palsy with aberrant regeneration secondary to cavernous sinus arachnoid cyst. ( 30555949 )
2019
3
Lower cranial nerve palsy during radiotherapy for glottic cancer in a patient with Wegener's granulomatosis: An interesting case report. ( 30680194 )
2019
4
Neurosyphilis presenting as cranial nerve palsy, an entity which is easy to miss. ( 30796075 )
2019
5
Long-term outcome of full tendon vertical rectus transposition with Foster suture in unilateral complete sixth cranial nerve palsy. ( 30936682 )
2019
6
Sixth cranial nerve palsy and ipsilateral segmental carotid arteritis after tooth alveolectomy. ( 30982133 )
2019
7
A 10-year-old female with unilateral seventh cranial nerve palsy. ( 30996593 )
2019
8
Newly occurring cranial nerve palsy after endovascular treatment of cavernous sinus dural arteriovenous fistulas. ( 31048455 )
2019
9
Third cranial nerve palsy and Chikungunya virus infection. ( 29271691 )
2018
10
Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. ( 29102606 )
2018
11
Disseminated Cryptococcosis With Severe Increased Intracranial Pressure Complicated With Cranial Nerve Palsy in a Child. ( 29189676 )
2018
12
Sixth cranial nerve palsy in an immunocompetent adult patient with varicella. ( 29628195 )
2018
13
Clinical Course and Prognostic Factors of Acquired Third, Fourth, and Sixth Cranial Nerve Palsy in Korean Patients. ( 29770635 )
2018
14
Sixth cranial nerve palsy and ipsilateral trigeminal neuralgia caused by vertebrobasilar dolichoectasia. ( 29780939 )
2018
15
Multiple Cranial Nerve Palsy Concomitant with Leptomeningeal Involvement in Multiple Myeloma: A Case Report and Review of Literature. ( 29951172 )
2018
16
Glossopharyngeal (IXth) cranial nerve palsy associated with postural change after accidental dural puncture. ( 29983279 )
2018
17
Combined Lateral Rectus Myectomy and Maximal Medial Rectus Resection in Complete Third Cranial Nerve Palsy. ( 30250857 )
2018
18
Ocular motor cranial nerve palsy and increased risk of stroke in the general population. ( 30321220 )
2018
19
Hypoglossal canal schwannoma causing isolated left 12th cranial nerve palsy. ( 30389733 )
2018
20
Bilateral Lower Cranial Nerve Palsy after Closed Head Injury: A Case Report and Review of Literature. ( 30662229 )
2018
21
Isolated Third Cranial Nerve Palsy Leading to the Diagnosis of Disseminated Burkitt Lymphoma: A Case Report and Literature Review. ( 28859023 )
2017
22
Third Cranial Nerve Palsy after a Chikungunya Virus Infection. ( 29135313 )
2017
23
A frontal external ventricular drain causing a third cranial nerve palsy. ( 27241884 )
2017
24
Imaging of Oculomotor (Third) Cranial Nerve Palsy. ( 27886888 )
2017
25
Perioptic neuritis related with varicella-zoster virus infection preceding sixth cranial nerve palsy and progressive outer retinal necrosis in a immunocompetent patient. ( 28131177 )
2017
26
Cranial nerve palsy following central neuraxial block in obstetrics - a review of the literature and analysis of 43 case reports. ( 28343842 )
2017
27
Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: a single institution experience of 104 patients. ( 28435298 )
2017
28
Carcinoma Prostate Presenting as Multiple Cranial Nerve Palsy. ( 28457045 )
2017
29
Lower cranial nerve palsy after the infrafloccular approach in microvascular decompression for hemifacial spasm. ( 28540133 )
2017
30
Neurological Imaging in Acquired Cranial Nerve Palsy: Ophthalmologists vs. Neurologists. ( 28759288 )
2017
31
Stroke risk among adult patients with third, fourth or sixth cranial nerve palsy: a Nationwide Cohort Study. ( 28772000 )
2017
32
Chronic myeloid leukemia presenting as multiple cranial nerve palsy. ( 28960704 )
2017
33
Isolated sixth Cranial Nerve Palsy in a Case Of Severe Pre-Eclampsia Presenting as Postpartum Diplopia. ( 28969214 )
2017
34
RUNX1-RUNX1T1-positive acute myeloid leukaemia presenting as bilateral proptosis and multiple cranial nerve palsy. ( 28993357 )
2017
35
Third cranial nerve palsy: an unusual manifestation of Mycoplasma pneumoniae. ( 29072872 )
2017
36
Calvarial-orbital Metastasis of Prostate Carcinoma which was Diagnosed with Sixth Cranial Nerve Palsy. ( 29114308 )
2017
37
Cranial Nerve Palsy after Onyx Embolization as a Treatment for Cerebral Vascular Malformation. ( 29159152 )
2017
38
Third Cranial Nerve Palsy in the Setting of Chikungunya Virus Infection. ( 27246445 )
2016
39
Sixth cranial nerve palsy due to acitretin. ( 25997624 )
2016
40
Radiographic occult cerebellar germinoma presenting with progressive ataxia and cranial nerve palsy. ( 26759273 )
2016
41
Cranial nerve palsy secondary to cerebrospinal fluid diversion. ( 26882270 )
2016
42
A Rare Case of Basioccipital Encephalomeningocele with Tethered Dermoid Presenting as Cranial Nerve Palsy: A Case Report. ( 27318872 )
2016
43
Isolated fourth cranial nerve palsy due to pituitary macroadenoma. ( 28050074 )
2016
44
Isolated unilateral sixth cranial nerve palsy: A rare presentation of dengue fever. ( 28461846 )
2016
45
[Malignant lymphoma presented as recurrent multiple cranial nerve palsy after spontaneous regression of oculomotor nerve palsy: A case report]. ( 26616489 )
2016
46
Traumatic internal carotid artery pseudoaneurysm. A rare cause of cranial nerve palsy. ( 25109537 )
2015
47
Blepharoptosis Associated With Third Cranial Nerve Palsy. ( 25376747 )
2015
48
Sixth cranial nerve palsy caused by gastric adenocarcinoma metastasis to the clivus. ( 25810862 )
2015
49
Occipital condyle fracture and lower cranial nerve palsy after blunt head trauma - a literature review and case report. ( 25897322 )
2015
50
Tapia's syndrome in the intensive care unit: a rare cause of combined cranial nerve palsy following intubation. ( 26088745 )
2015
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Variations for Cranial Nerve Palsy

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Expression for Cranial Nerve Palsy

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Search GEO for disease gene expression data for Cranial Nerve Palsy.
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Pathways for Cranial Nerve Palsy

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GO Terms for Cranial Nerve Palsy

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Molecular functions related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 8.8 APC HIST1H3B SCYL1
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Sources for Cranial Nerve Palsy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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