MCID: CRN035
MIFTS: 44

Cranial Nerve Palsy

Categories: Neuronal diseases
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Aliases & Classifications for Cranial Nerve Palsy

MalaCards integrated aliases for Cranial Nerve Palsy:

Name: Cranial Nerve Palsy 11 14 16
Cranial Nerve Paralysis 11 28
Cranial Nerve Diseases 43 71
Cranial Nerve Palsies 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3817
MeSH 43 D003389
NCIt 49 C26941
SNOMED-CT 68 73013002
UMLS 71 C0010266 C0151311

Summaries for Cranial Nerve Palsy

Disease Ontology: 11 A cranial nerve disease that is characterized by complete or partial weakness or paralysis of the areas served by the affected nerve.

MalaCards based summary: Cranial Nerve Palsy, also known as cranial nerve paralysis, is related to fourth cranial nerve palsy and multiple cranial nerve palsy, and has symptoms including ophthalmoplegia, circumoral paresthesia and neurologic symptoms. An important gene associated with Cranial Nerve Palsy is CRP (C-Reactive Protein), and among its related pathways/superpathways is Mitochondrial complex II assembly. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and prostate, and related phenotypes are homeostasis/metabolism and nervous system

Related Diseases for Cranial Nerve Palsy

Diseases in the Cranial Nerve Palsy family:

Multiple Cranial Nerve Palsy

Diseases related to Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 952)
# Related Disease Score Top Affiliating Genes
1 fourth cranial nerve palsy 33.0 CRP AVP
2 multiple cranial nerve palsy 32.6 PRTN3 PRL CRP CD4 ACE
3 abducens palsy 32.1 SERPINC1 PRL POMC MOG F2 CRP
4 neurosarcoidosis 31.5 TNF PRTN3 MOG CRP CD4 AQP4
5 pituitary apoplexy 31.0 PRL POMC AVP
6 bell's palsy 30.8 TNF CRP CD4 ALB ACE
7 meningitis 30.8 TNF CRP AQP4 ALB
8 intracranial hypotension 30.8 SERPINC1 F2 CRP ALB
9 sphenoid sinusitis 30.7 POMC CRP AVP
10 headache 30.6 TNF PRL ALB
11 intracranial hypertension, idiopathic 30.6 POMC MOG AQP4
12 mucormycosis 30.6 TNF CRP CD4
13 neuritis 30.5 TNF MOG AQP4
14 poliomyelitis 30.5 TNF CD4 ALB
15 horner's syndrome 30.5 SYP SDHD SDHB CRP
16 lemierre's syndrome 30.4 SERPINC1 F2 CRP
17 tolosa-hunt syndrome 30.4 PRTN3 CRP ACE
18 hydrocephalus 30.4 TNF SYP PRL AQP4 ACE
19 parotitis 30.4 CRP CD4 ALB
20 covid-19 30.4 TNF F2 CRP ACE
21 cryptococcal meningitis 30.4 TNF CD4 ALB
22 common cold 30.4 TNF CRP CD4
23 dengue disease 30.4 TNF CD4 ALB
24 pituitary infarct 30.4 PRL POMC AVP
25 sheehan syndrome 30.4 PRL POMC AVP
26 vascular disease 30.3 TNF SERPINC1 F2 CRP ALB ACE
27 guillain-barre syndrome 30.3 TNF MOG ALB
28 neuromyelitis optica 30.3 MOG CRP AQP4
29 optic neuritis 30.3 TNF MOG AQP4
30 secondary progressive multiple sclerosis 30.3 MOG CD4 AQP4
31 quadriplegia 30.3 SDHD SDHB MOG
32 thrombophlebitis 30.3 SERPINC1 F2 CRP ALB
33 aseptic meningitis 30.3 TNF MOG CRP CD4 ALB
34 acute retinal necrosis syndrome 30.2 TNF CD4 ACE
35 septooptic dysplasia 30.2 PRL POMC AVP
36 amyloidosis 30.2 TNF SYP CRP ALB
37 sagittal sinus thrombosis 30.2 SERPINC1 F2 CRP
38 legionnaire disease 30.2 TNF CRP CD4
39 acute kidney failure 30.2 PRTN3 F2 ALB ACE
40 carotid stenosis 30.2 TNF CRP ACE
41 sarcoidosis 1 30.1 TNF PRTN3 CRP CD4 ALB ACE
42 cavernous hemangioma 30.1 SERPINC1 F2 ALB
43 transient cerebral ischemia 30.1 SERPINC1 F2 CRP ALB ACE
44 nonarteritic anterior ischemic optic neuropathy 30.1 SERPINC1 MOG F2 CRP AQP4
45 anterior uveitis 30.1 TNF CRP CD4 ACE
46 retinal artery occlusion 30.1 SERPINC1 F2 CRP ACE
47 spondyloarthropathy 1 30.1 TNF PRTN3 CRP CD4
48 central retinal artery occlusion 30.1 SERPINC1 PRTN3 F2 CRP
49 granulomatosis with polyangiitis 30.1 TNF PRTN3 CRP CD4
50 cerebrovascular disease 30.1 TNF F2 CRP ALB ACE

Comorbidity relations with Cranial Nerve Palsy via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Cranial Nerve Palsy:



Diseases related to Cranial Nerve Palsy

Symptoms & Phenotypes for Cranial Nerve Palsy

UMLS symptoms related to Cranial Nerve Palsy:


ophthalmoplegia; circumoral paresthesia; neurologic symptoms

MGI Mouse Phenotypes related to Cranial Nerve Palsy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ACE ALB AQP4 AVP CD4 CRP
2 nervous system MP:0003631 10.21 AQP4 AVP CD4 F2 MOG NF2
3 endocrine/exocrine gland MP:0005379 10.1 ACE ALB AQP4 CD4 F2 NF2
4 neoplasm MP:0002006 10.08 ACE ALB NF2 POMC PRL SDHB
5 renal/urinary system MP:0005367 10.06 ACE ALB AQP4 AVP NF2 POMC
6 cellular MP:0005384 10.03 ACE ALB CD4 F2 MOG POMC
7 no phenotypic analysis MP:0003012 10 AQP4 AVP CD4 POMC PRTN3 SDHB
8 behavior/neurological MP:0005386 9.97 ACE AQP4 AVP F2 MOG NF2
9 immune system MP:0005387 9.86 ACE ALB AQP4 AVP CD4 CRP
10 mortality/aging MP:0010768 9.47 ACE ALB AQP4 AVP CD4 F2

Drugs & Therapeutics for Cranial Nerve Palsy

Drugs for Cranial Nerve Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
2
Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
3
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 4894 5755
4
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
5
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5 1875
6
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 4159 6741
7
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7 4897
8
Cortisone Experimental Phase 1, Phase 2 53-06-5 222786
9 Antineoplastic Agents, Hormonal Phase 1, Phase 2
10 Neuroprotective Agents Phase 1, Phase 2
11 Hormones Phase 1, Phase 2
12 Hormone Antagonists Phase 1, Phase 2
13 Antiemetics Phase 1, Phase 2
14 glucocorticoids Phase 1, Phase 2
15 Anti-Inflammatory Agents Phase 1, Phase 2
16
Methylprednisolone Acetate Phase 1, Phase 2 584547
17 Gastrointestinal Agents Phase 1, Phase 2
18 Protective Agents Phase 1, Phase 2
19 Parenteral Nutrition Solutions Phase 2
20 Ferrosoferric Oxide Phase 2
21 Pharmaceutical Solutions Phase 2
22 Hematinics Phase 2
23
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial and Data Registry Recruiting NCT04151082 Phase 1, Phase 2 Methylprednisolone;Prednisone
2 The Feasibility of Steady State CBV Mapping Using Ferumoxytol Immediately After Gadolinium Enhanced MRI of the CNS Recruiting NCT03270059 Phase 2 Ferumoxytol;Gadolinium
3 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
4 Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit Unknown status NCT03659760
5 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
6 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Completed NCT03206541
7 Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy Recruiting NCT02978911
8 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cranial Nerve Palsy

Cochrane evidence based reviews: cranial nerve diseases

Genetic Tests for Cranial Nerve Palsy

Genetic tests related to Cranial Nerve Palsy:

# Genetic test Affiliating Genes
1 Cranial Nerve Paralysis 28

Anatomical Context for Cranial Nerve Palsy

Organs/tissues related to Cranial Nerve Palsy:

MalaCards : Pituitary, Brain, Prostate, Bone, Tongue, Pons, Temporal Lobe

Publications for Cranial Nerve Palsy

Articles related to Cranial Nerve Palsy:

(show top 50) (show all 1952)
# Title Authors PMID Year
1
Meningitis as a complication of Sjögren's syndrome. 62
36270916 2023
2
An Analysis of Sex-Based Outcomes Following Transcarotid Artery Revascularization. 62
36167464 2023
3
Cerebral hydatid cyst in children: A case series of 21 patients and review of literature. 62
35907445 2022
4
Adult diffuse intrinsic pontine glioma: clinical, radiological, pathological, molecular features, and treatments of 96 patients. 62
35395636 2022
5
Ocular motility disorders following coronavirus disease-19 vaccination. 62
36383278 2022
6
Paragangliomas of the head and neck. 62
35178777 2022
7
Adverse events are not increased with trainee participation in transcarotid revascularization. 62
36377465 2022
8
Outcomes After Endovascular Treatment of Direct Carotid Cavernous Fistulas: Systematic Review and Meta-Analysis. 62
36334712 2022
9
Endoscopic Debridement of Post-Radiation Nasopharyngeal Necrosis: The Effects of Resurfacing With a Vascularized Flap. 62
36097841 2022
10
The Oculomotor Nerve: Anatomy and Pathology. 62
36116851 2022
11
[CASE SERIES OF EARLY NEUROIMAGING IN PATIENTS WITH VASCULAR RISK FACTORS AND ISOLATED SIX CRANIAL NERVE PALSY, DEMONSTRATING THE DILEMMA OF EARLY IMAGING]. 62
36315208 2022
12
Difficult intubation and postoperative aspiration pneumonia associated with Moebius syndrome: a case report. 62
36221060 2022
13
Rare Ischemic Complications of Giant Cell Arteritis: Case Series and Literature Review. 62
36240129 2022
14
Acute cerebellitis, transverse myelitis and polyradiculoneuritis related to post-COVID-19 infection. 62
36175361 2022
15
Macrovascular Decompression with the Transposition Method Using Teflon Sling for Trigeminal Neuralgia Caused by the Vertebrobasilar Artery. 62
36113714 2022
16
Bilateral sixth cranial nerve palsy, the first presenting feature of hemorrhagic apoplexy of pituitary macroadenoma: A case report. 62
35985120 2022
17
Isolated abducens nerve palsy associated with coronavirus disease: an 8-month follow-up. 62
34852059 2022
18
Incidental finding of metastatic prostatic adenocarcinoma of cerebellopontine angle presenting as acoustic neuroma: A case report and review of literature. 62
35969908 2022
19
Camrelizumab-Induced Isolate Abducens Neuritis: A Rare Ophthalmic Immune-Related Adverse Events. 62
36138977 2022
20
Horner Syndrome in Giant Cell Arteritis: Case Series and Review of the Literature. 62
35427255 2022
21
Intradural spinal seeding metastasis of clival chordoma: a case report. 62
36237273 2022
22
Use of a Rigid-Tipped Microguidewire for the Endovascular Treatment of Cavernous Sinus Dural Arteriovenous Fistulas with an Occluded Inferior Petrosal Sinus. 62
35853478 2022
23
Surgical and Functional Outcome after Resection of 64 Petroclival Meningiomas. 62
36139677 2022
24
Posterior Fossa Calcifying Pseudoneoplasm of the Neuraxis (CAPNON): Presentation of Three Surgical Cases. 62
35964906 2022
25
Causes of Vocal Fold Paralysis. 62
33090900 2022
26
Gamma Knife Radiosurgery for Indirect Dural Carotid-Cavernous Fistula: Long-Term Ophthalmological Outcome. 62
36013354 2022
27
Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period. 62
35696322 2022
28
Pituitary apoplexy presenting as isolated third cranial nerve palsy: case series. 62
36017525 2022
29
Incidence, Management, and Outcome of Pulled-in-Two Syndrome Associated With Strabismus Surgery. 62
35938640 2022
30
The Quadrangular Space, Endonasal Access to the Meckel Cave: Technical Considerations and Clinical Series. 62
35331950 2022
31
A Case of Intratemporal Rhabdomyosarcoma in a Child Presenting with VIIth, IXth, and Xth Cranial Nerve Paralysis. 62
35801554 2022
32
Sparsely Granulated Corticotroph Pituitary Macroadenoma Presenting With Pituitary Apoplexy Resulting in Remission of Hypercortisolism. 62
35959088 2022
33
Third Nerve Palsy Due to Intracranial Aneurysms and Recovery after Endovascular Coiling. 62
34167603 2022
34
Cerebral small vessel disease as imaging biomarker predicting ocular cranial nerve palsy of presumed ischemic origin at admission. 62
35851307 2022
35
Trends in Etiologies, Demographics, and Neuroimaging in New-Onset Adult Strabismus at an Ophthalmic Emergency Department. 62
35192377 2022
36
Skull Base Metastasis of Breast Cancer With Oculomotor and Trochlear Nerve Palsy. 62
33035131 2022
37
Radiculoneuritis due to Lyme disease in a North American child. 62
35430099 2022
38
Surgical and Endovascular Treatment of Saccular Posterior Inferior Cerebellar Artery Aneurysms: Systematic Review and Meta-Analysis. 62
35257955 2022
39
The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions. 62
35877220 2022
40
Optimal Diagnostic Criteria and a Staging System for Otogenic Skull Base Osteomyelitis. 62
35832975 2022
41
Craniofacial Chondromyxoid Fibromas: A Systematic Review and Analysis Based on Anatomic Locations. 62
34710582 2022
42
Larger Than Larger: Huge Amounts of Recession-Resection Surgery for Third Nerve Palsy. 62
35758195 2022
43
Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy. 62
35313474 2022
44
Clinical Characteristics for Predicting Recovery of Acquired Fourth Cranial Nerve Palsy. 62
34860742 2022
45
A Rare and Unusual Cause of Tenth Cranial Nerve Palsy Leading to Dysphagia. 62
33811519 2022
46
Association between migraine and risk of ocular motor cranial nerve palsy. 62
35732687 2022
47
Strabismus outcomes after surgery: the nationwide SOS France study. 62
34982221 2022
48
Gradenigo's syndrome presenting as IX and X cranial nerve palsy without clinically apparent ear infection: A case report and review of literature. 62
35330846 2022
49
Clinical Features Associated With Need for Mechanical Ventilation in Children With Guillain-Barré Syndrome: Retrospective Cohort From India. 62
35220343 2022
50
Orbital Plasmacytoma in a Young Patient With HIV Presenting as Multiple Cranial Nerve Palsy. 62
35338072 2022

Variations for Cranial Nerve Palsy

Expression for Cranial Nerve Palsy

Search GEO for disease gene expression data for Cranial Nerve Palsy.

Pathways for Cranial Nerve Palsy

Pathways related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.7 SDHD SDHB

GO Terms for Cranial Nerve Palsy

Cellular components related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.73 TNF MOG F2 CD4 AQP4 ACE
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHB

Biological processes related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 riboflavin transport GO:0032218 9.67 SLC52A3 SLC52A1
2 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.63 TNF PRL F2
3 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.62 SDHD SDHB
4 riboflavin metabolic process GO:0006771 9.56 SLC52A3 SLC52A1
5 viral entry into host cell GO:0046718 9.56 SLC52A1 MOG CD4 AVP
6 vasoconstriction GO:0042310 9.1 CRP AVP ACE

Molecular functions related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.7 TNF PRTN3 POMC MOG F2 AVP
2 ubiquinone binding GO:0048039 9.56 SDHD SDHB
3 riboflavin transmembrane transporter activity GO:0032217 9.46 SLC52A3 SLC52A1
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.92 SDHD SDHB

Sources for Cranial Nerve Palsy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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