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MCID: CRN035
MIFTS: 40

Cranial Nerve Palsy

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cranial Nerve Palsy

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MalaCards integrated aliases for Cranial Nerve Palsy:

Name: Cranial Nerve Palsy 12 15
Cranial Nerve Paralysis 12 29
Cranial Nerve Diseases 44 73
Cranial Nerve Palsies 73

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:3817
MeSH 44 D003389
NCIt 50 C26941
SNOMED-CT 68 73013002
ICD10 33 G53 G52.8
UMLS 73 C0151311
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Summaries for Cranial Nerve Palsy

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MalaCards based summary : Cranial Nerve Palsy, also known as cranial nerve paralysis, is related to fourth cranial nerve palsy and sphenoid sinusitis, and has symptoms including ophthalmoplegia, circumoral paresthesia and neurologic symptoms. An important gene associated with Cranial Nerve Palsy is APC (APC, WNT Signaling Pathway Regulator), and among its related pathways/superpathways is G12-G13 in Cellular Signaling. The drugs Pyrimethamine and Sulfadiazine have been mentioned in the context of this disorder. Affiliated tissues include b cells, pituitary and brain.

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Related Diseases for Cranial Nerve Palsy

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Diseases in the Cranial Nerve Palsy family:

Multiple Cranial Nerve Palsy

Diseases related to Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 fourth cranial nerve palsy 34.2 APC CHN1
2 sphenoid sinusitis 29.7 RHNO1 SLC25A16
3 multiple cranial nerve palsy 12.4
4 cranial nerve disease 12.4
5 fourth cranial nerve palsy, familial congenital 12.4
6 third cranial nerve disease 12.1
7 congenital oculomotor nerve palsy 11.5
8 congenital trochlear nerve palsy 11.5
9 oculomotor nerve paralysis 11.2
10 bell's palsy 11.2
11 abducens nerve disease 11.2
12 congenital abducens nerve palsy 11.2
13 brown-vialetto-van laere syndrome 1 11.2
14 behcet syndrome 11.0
15 cowden syndrome 1 11.0
16 paraganglioma and gastric stromal sarcoma 11.0
17 diabetic neuropathy 11.0
18 eastern equine encephalitis 11.0
19 tolosa-hunt syndrome 11.0
20 glomus vagale tumor 11.0
21 aneurysm 10.3
22 lymphoma 10.2
23 carotid artery dissection 10.2
24 meningitis 10.2
25 nasopharyngitis 10.2
26 pituitary apoplexy 10.2
27 cerebritis 10.2
28 nasopharyngeal carcinoma 10.1
29 prostatitis 10.1
30 intracranial hypotension 10.1
31 neuropathy 10.1
32 systemic lupus erythematosus 10.0
33 intracranial aneurysm 10.0
34 arachnoiditis 10.0
35 herpes zoster 10.0
36 lupus erythematosus 10.0
37 arachnoid cysts 10.0
38 intracranial sinus thrombosis 10.0 NT5C3A RHNO1
39 cavernous sinus thrombosis 10.0 NT5C3A RHNO1
40 prostate cancer 10.0
41 strabismus 10.0
42 myeloma, multiple 10.0
43 sinusitis 10.0
44 chikungunya 10.0
45 lemierre's syndrome 10.0
46 retinitis 10.0
47 herpes zoster ophthalmicus 10.0
48 spontaneous intracranial hypotension 10.0
49 melkersson-rosenthal syndrome 9.9
50 thrombophilia due to thrombin defect 9.9

Comorbidity relations with Cranial Nerve Palsy via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Cranial Nerve Palsy:



Diseases related to Cranial Nerve Palsy
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Symptoms & Phenotypes for Cranial Nerve Palsy

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UMLS symptoms related to Cranial Nerve Palsy:


ophthalmoplegia, circumoral paresthesia, neurologic symptoms
Sources

Drugs & Therapeutics for Cranial Nerve Palsy

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Drugs for Cranial Nerve Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
2
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
6
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 58-05-9 143 6006
7 Anti-Infective Agents Phase 4,Phase 2,Phase 3
8 Antimalarials Phase 4
9 Antiparasitic Agents Phase 4,Phase 2
10 Antiprotozoal Agents Phase 4,Phase 2
11 Folic Acid Antagonists Phase 4
12 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
13 Vitamin B Complex Phase 4,Phase 2,Phase 3
14 Folate Nutraceutical Phase 4,Phase 2,Phase 3
15 Vitamin B9 Nutraceutical Phase 4,Phase 2,Phase 3
16
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
17
Cytarabine Approved, Investigational Phase 2, Phase 3 147-94-4 6253
18
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
19
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
20
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
21
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
22
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
23
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
24
Rasburicase Approved, Investigational Phase 2, Phase 3 134774-45-1
25
rituximab Approved Phase 2, Phase 3 174722-31-7 10201696
26
Vincristine Approved, Investigational Phase 2, Phase 3 2068-78-2, 57-22-7 5978
27
Doxil Approved June 1999 Phase 2, Phase 3 31703
28 Adjuvants, Immunologic Phase 2, Phase 3
29 Alkylating Agents Phase 2, Phase 3
30 Anti-Bacterial Agents Phase 2, Phase 3
31 Antibiotics, Antitubercular Phase 2, Phase 3
32 Antidotes Phase 2, Phase 3
33 Anti-Inflammatory Agents Phase 2, Phase 3
34 Antimetabolites Phase 2, Phase 3
35 Antimetabolites, Antineoplastic Phase 2, Phase 3
36 Antineoplastic Agents, Alkylating Phase 2, Phase 3
37 Antineoplastic Agents, Hormonal Phase 2, Phase 3
38 Antirheumatic Agents Phase 2, Phase 3
39 Antiviral Agents Phase 2, Phase 3
40 Etoposide phosphate Phase 2, Phase 3
41 glucocorticoids Phase 2, Phase 3
42 Hematinics Phase 2, Phase 3
43 Hormone Antagonists Phase 2, Phase 3
44 Hormones Phase 2, Phase 3
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
46 Immunosuppressive Agents Phase 2, Phase 3
47 Micronutrients Phase 2, Phase 3
48 Protective Agents Phase 2, Phase 3
49 Topoisomerase Inhibitors Phase 2, Phase 3
50 Trace Elements Phase 2, Phase 3

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
2 EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
3 Mature B-Cell Lymphoma And Leukemia Study III Recruiting NCT01046825 Phase 2, Phase 3 COPAD;COP, COPD M3, CYM;COP, COPADM8, CYVE
4 " Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " Not yet recruiting NCT02841098 Phase 3 Optimal medical therapy alone
5 Treatment for Advanced B-Cell Lymphoma Recruiting NCT01859819 Phase 2 Rituximab;IT Cytarabine
6 Treatment With Tamoxifen in Cryptococcal Meningitis Recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
7 Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage Withdrawn NCT02165644 Phase 2 Acetazolamide;Nimodipine
8 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
9 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070 Not Applicable
10 Cranial Nerves Tractography Recruiting NCT02978911 Not Applicable
11 Microembolisation After Carotid Revascularisation Recruiting NCT03303430
12 Reclaimâ„¢ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (OCD) Recruiting NCT02773082 Not Applicable
13 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541
14 Mid-term Data Collection of the Treatment of Intracranial Aneurysms With the WEBâ„¢ Aneurysm Embolization System Withdrawn NCT03379714

Search NIH Clinical Center for Cranial Nerve Palsy

Cochrane evidence based reviews: cranial nerve diseases

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Genetic Tests for Cranial Nerve Palsy

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Genetic tests related to Cranial Nerve Palsy:

# Genetic test Affiliating Genes
1 Cranial Nerve Paralysis 29
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Anatomical Context for Cranial Nerve Palsy

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MalaCards organs/tissues related to Cranial Nerve Palsy:

41
B Cells, Pituitary, Brain, Prostate, Bone, T Cells, Myeloid
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Publications for Cranial Nerve Palsy

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Articles related to Cranial Nerve Palsy:

(show top 50) (show all 306)
# Title Authors Year
1
Clinical Course and Prognostic Factors of Acquired Third, Fourth, and Sixth Cranial Nerve Palsy in Korean Patients. ( 29770635 )
2018
2
Multiple cranial nerve palsies secondary to a recurrence of Hansen's disease. ( 29330278 )
2018
3
Unilateral lower cranial nerve palsies as the sole manifestation of internal carotid artery dissection: Case report. ( 29675876 )
2018
4
Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. ( 29102606 )
2018
5
Multiple Cranial Nerve Palsy Concomitant with Leptomeningeal Involvement in Multiple Myeloma: A Case Report and Review of Literature. ( 29951172 )
2018
6
Severe localised granulomatosis with polyangiitis (Wegener's granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review. ( 29716529 )
2018
7
Sixth cranial nerve palsy in an immunocompetent adult patient with varicella. ( 29628195 )
2018
8
Sixth cranial nerve palsy and ipsilateral trigeminal neuralgia caused by vertebrobasilar dolichoectasia. ( 29780939 )
2018
9
Disseminated Cryptococcosis with Severe Increased Intracranial Pressure Complicated with Cranial Nerve Palsy in a Child. ( 29189676 )
2017
10
RUNX1-RUNX1T1-positive acute myeloid leukaemia presenting as bilateral proptosis and multiple cranial nerve palsy. ( 28993357 )
2017
11
Neurological Imaging in Acquired Cranial Nerve Palsy: Ophthalmologists vs. Neurologists. ( 28759288 )
2017
12
Lower cranial nerve palsy after the infrafloccular approach in microvascular decompression for hemifacial spasm. ( 28540133 )
2017
13
Ocular cranial nerve palsies secondary to sphenoid sinusitis. ( 29204579 )
2017
14
A case of idiopathic hypertrophic pachymeningitis presenting with chronic headache and multiple cranial nerve palsies: A case report. ( 28723776 )
2017
15
Imaging of Oculomotor (Third) Cranial Nerve Palsy. ( 27886888 )
2017
16
Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: a single institution experience of 104 patients. ( 28435298 )
2017
17
Perioptic neuritis related with varicella-zoster virus infection preceding sixth cranial nerve palsy and progressive outer retinal necrosis in a immunocompetent patient. ( 28131177 )
2017
18
Carcinoma Prostate Presenting as Multiple Cranial Nerve Palsy. ( 28457045 )
2017
19
Isolated Third Cranial Nerve Palsy Leading to the Diagnosis of Disseminated Burkitt Lymphoma: A Case Report and Literature Review. ( 28859023 )
2017
20
Third Cranial Nerve Palsy after a Chikungunya Virus Infection. ( 29135313 )
2017
21
Stroke risk among adult patients with third, fourth or sixth cranial nerve palsy: a Nationwide Cohort Study. ( 28772000 )
2017
22
Isolated sixth Cranial Nerve Palsy in a Case Of Severe Pre-Eclampsia Presenting as Postpartum Diplopia. ( 28969214 )
2017
23
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome. ( 28211985 )
2017
24
Third cranial nerve palsy: an unusual manifestation of Mycoplasma pneumoniae. ( 29072872 )
2017
25
Third cranial nerve palsy and Chikungunya virus infection. ( 29271691 )
2017
26
Relapsing polychondritis as an unusual cause of multiple cranial nerve palsies-A Case report. ( 28093782 )
2017
27
Calvarial-orbital Metastasis of Prostate Carcinoma which was Diagnosed with Sixth Cranial Nerve Palsy. ( 29114308 )
2017
28
Cranial nerve palsy following central neuraxial block in obstetrics - a review of the literature and analysis of 43 case reports. ( 28343842 )
2017
29
Cranial Nerve Palsy after Onyx Embolization as a Treatment for Cerebral Vascular Malformation. ( 29159152 )
2017
30
Chronic myeloid leukemia presenting as multiple cranial nerve palsy. ( 28960704 )
2017
31
Isolated fourth cranial nerve palsy due to pituitary macroadenoma. ( 28050074 )
2016
32
A rare case of third cranial nerve palsy. ( 27728318 )
2016
33
Cranial nerve palsy secondary to cerebrospinal fluid diversion. ( 26882270 )
2016
34
A Rare Case of Basioccipital Encephalomeningocele with Tethered Dermoid Presenting as Cranial Nerve Palsy: A Case Report. ( 27318872 )
2016
35
Increased Risk of Stroke in Patients with Isolated Third, Fourth, or Sixth Cranial Nerve Palsies: A Nationwide Cohort Study. ( 26849146 )
2016
36
Isolated unilateral sixth cranial nerve palsy: A rare presentation of dengue fever. ( 28461846 )
2016
37
[Malignant lymphoma presented as recurrent multiple cranial nerve palsy after spontaneous regression of oculomotor nerve palsy: A case report]. ( 26616489 )
2016
38
A case of possible paraneoplastic neurological syndrome presenting as multiple cranial nerve palsies associated with gallbladder cancer. ( 27498818 )
2016
39
Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy. ( 27436207 )
2016
40
A frontal external ventricular drain causing a third cranial nerve palsy. ( 27241884 )
2016
41
Cerebrospinal fluid dissemination of anaplastic intraventricular meningioma: report of a case presenting with progressive brainstem dysfunction and multiple cranial nerve palsies. ( 27245327 )
2016
42
Isolated neurosarcoidosis presenting with multiple cranial nerve palsies. ( 27168947 )
2016
43
A case of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated hypertrophic pachymeningitis presenting with multiple cranial nerve palsies and diabetes insipidus. ( 27098904 )
2016
44
Radiographic occult cerebellar germinoma presenting with progressive ataxia and cranial nerve palsy. ( 26759273 )
2016
45
Third Cranial Nerve Palsy in the Setting of Chikungunya Virus Infection. ( 27246445 )
2016
46
Radiation-induced lower cranial nerve palsy in patients with head and neck carcinoma. ( 26171186 )
2015
47
Sixth cranial nerve palsy due to acitretin. ( 25997624 )
2015
48
Multiple concomitant cranial nerve palsies secondary to preeclampsia. ( 25768245 )
2015
49
Tapia's syndrome in the intensive care unit: a rare cause of combined cranial nerve palsy following intubation. ( 26088745 )
2015
50
Residual Strabismus in Children Following Improvement of Cranial Nerve Palsies Affecting Ocular Ductions. ( 26564932 )
2015
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Variations for Cranial Nerve Palsy

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Expression for Cranial Nerve Palsy

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Search GEO for disease gene expression data for Cranial Nerve Palsy.
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Pathways for Cranial Nerve Palsy

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Pathways related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G12-G13 in Cellular Signaling 64
10.71 APC CHN1
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GO Terms for Cranial Nerve Palsy

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Sources for Cranial Nerve Palsy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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