MCID: CRS001
MIFTS: 45

Crescentic Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Crescentic Glomerulonephritis

MalaCards integrated aliases for Crescentic Glomerulonephritis:

Name: Crescentic Glomerulonephritis 12 6 15
Idiopathic Crescentic Glomerulonephritis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13139
SNOMED-CT 69 45406000
UMLS 74 C0403416

Summaries for Crescentic Glomerulonephritis

MalaCards based summary : Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to rapidly progressive glomerulonephritis and glomerulonephritis. An important gene associated with Crescentic Glomerulonephritis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Degradation of the extracellular matrix and Development VEGF signaling via VEGFR2 - generic cascades. The drugs Prednisolone phosphate and rituximab have been mentioned in the context of this disorder. Affiliated tissues include kidney, neutrophil and lung, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Crescentic Glomerulonephritis

Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 33.2 ICAM1 MPO
2 glomerulonephritis 31.8 CCL2 ICAM1 MPO NPHS2 VCAM1
3 goodpasture syndrome 30.3 MPO VCAM1
4 bronchiectasis 30.3 BPI CTSG MPO
5 macular retinal edema 30.2 CCL2 ICAM1
6 pulmonary sarcoidosis 30.2 CCL2 CCR5 ICAM1
7 henoch-schoenlein purpura 30.2 ICAM1 MPO VCAM1
8 granulomatosis with polyangiitis 30.0 BPI CTSG MPO
9 vasculitis 30.0 BPI CCL2 CTSG ICAM1 MPO SELE
10 rheumatoid arthritis 30.0 CCL2 ICAM1 SELE VCAM1
11 rheumatoid vasculitis 30.0 ICAM1 SELE VCAM1
12 kidney disease 29.9 CCL2 NPHS2 SERPINE1 WT1
13 nephrotic syndrome 29.7 NPHS2 PTPRO WT1
14 myocardial infarction 29.7 CCL2 CCR5 ICAM1 MPO SERPINE1
15 pre-eclampsia 29.5 ICAM1 SELE SERPINE1 VCAM1
16 systemic lupus erythematosus 29.5 CCL2 CCR5 CTSG ICAM1 MPO SELE
17 focal segmental glomerulosclerosis 29.2 NPHS2 PTPRO SYNPO WT1
18 endocarditis 10.5
19 membranous nephropathy 10.5
20 arthritis 10.4
21 pauci-immune glomerulonephritis 10.4
22 pauci-immune glomerulonephritis without anca 10.4
23 pauci-immune glomerulonephritis with anca 10.4
24 iga glomerulonephritis 10.4
25 cerebral aneurysms 10.4 CCL2 MPO
26 herpes simplex virus keratitis 10.4 CCL2 ICAM1
27 erdheim-chester disease 10.3 CCL2 CCR5
28 systemic scleroderma 10.3
29 amyloidosis 10.3
30 ascending cholangitis 10.3 CCL2 MPO
31 cortical thymoma 10.3 ICAM1 VCAM1
32 shwartzman phenomenon 10.3 ICAM1 VCAM1
33 lymphoma 10.3
34 brachydactyly, type e2 10.3 ICAM1 VCAM1
35 pleurisy 10.3 CCL2 ICAM1 MPO
36 sjogren syndrome 10.3
37 churg-strauss syndrome 10.3
38 allergic angiitis 10.3
39 eosinophilic granulomatosis with polyangiitis 10.3
40 autoimmune disease of central nervous system 10.2 CCL2 CCR5 ICAM1
41 peritonitis 10.2 CCL2 ICAM1 MPO
42 mesangial proliferative glomerulonephritis 10.2 CCL2 CCR5
43 limbal stem cell deficiency 10.2 ICAM1 VCAM1
44 respiratory system disease 10.2 CCL2 ICAM1 MPO
45 heterophyiasis 10.2 ICAM1 SELE
46 oral lichen planus 10.2 CCR5 ICAM1 VCAM1
47 renal cell carcinoma, nonpapillary 10.2
48 scleroderma, familial progressive 10.2
49 infective endocarditis 10.2
50 hemolytic-uremic syndrome 10.2

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to Crescentic Glomerulonephritis

Symptoms & Phenotypes for Crescentic Glomerulonephritis

MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 CCR5 ICAM1 MPO NPHS2 PTPRO SELE
2 hematopoietic system MP:0005397 9.86 CCR5 CTSG ICAM1 MPO SELE SERPINE1
3 immune system MP:0005387 9.85 CCL2 CCR5 CTSG ICAM1 MPO SELE
4 mortality/aging MP:0010768 9.65 CCR5 CTSG ICAM1 MPO NPHS2 SELE
5 neoplasm MP:0002006 9.02 CCR5 CTSG ICAM1 SERPINE1 WT1

Drugs & Therapeutics for Crescentic Glomerulonephritis

Drugs for Crescentic Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
2
rituximab Approved Phase 3 174722-31-7 10201696
3
Acetaminophen Approved Phase 3 103-90-2 1983
4
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
5
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
6
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
7
Clemastine Approved, Investigational Phase 3 15686-51-8 26987
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
9
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
10
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
11
Prednisolone hemisuccinate Experimental Phase 3,Phase 2 2920-86-7
12 Hormones Phase 3,Phase 2
13 Antineoplastic Agents, Hormonal Phase 3,Phase 2
14 Gastrointestinal Agents Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Alkylating Agents Phase 3
17 Immunologic Factors Phase 3,Phase 2,Not Applicable
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Immunosuppressive Agents Phase 3,Phase 2
20 glucocorticoids Phase 3,Phase 2
21 Methylprednisolone Acetate Phase 3,Phase 2
22 Antiemetics Phase 3,Phase 2
23 Antibodies Phase 3,Not Applicable
24 Autonomic Agents Phase 3,Phase 2
25 Antirheumatic Agents Phase 3
26 Anti-Inflammatory Agents Phase 3,Phase 2
27 Antibodies, Antineutrophil Cytoplasmic Phase 3
28 Protective Agents Phase 3,Phase 2
29 Antineoplastic Agents, Immunological Phase 3
30 Immunoglobulins Phase 3,Not Applicable
31 Hormone Antagonists Phase 3,Phase 2
32 Prednisolone acetate Phase 3,Phase 2
33 Neuroprotective Agents Phase 3,Phase 2
34 Antineoplastic Agents, Alkylating Phase 3
35 Immunoglobulin A Phase 2, Phase 3
36
Lisinopril Approved, Investigational Phase 2 83915-83-7, 76547-98-3 5362119
37
protease inhibitors Phase 2
38 HIV Protease Inhibitors Phase 2
39 Angiotensin-Converting Enzyme Inhibitors Phase 2
40 Antihypertensive Agents Phase 2
41 Cardiotonic Agents Phase 2
42 Autoantibodies Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoadsorption in Anti-GBM Glomerulonephritis. Recruiting NCT02765789 Phase 4
2 Exploring Durable Remission With Rituximab in Antineutrophil Cytoplasmic Antibody(ANCA)-Associated Vasculitis Recruiting NCT03942887 Phase 3 Rituximab;endoxan;Methylprednisolone;Prednisolone
3 Trial of Plasma Exchange for Severe Crescentic IgA Nephropathy Enrolling by invitation NCT02647255 Phase 2, Phase 3 Methylprednisolone pulse
4 ACE-inhibitors in Extracapillary Glomerulonephritis Recruiting NCT02682459 Phase 2 Lisinopril
5 Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)? Recruiting NCT03664908 Not Applicable
6 Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research Recruiting NCT03929887

Search NIH Clinical Center for Crescentic Glomerulonephritis

Genetic Tests for Crescentic Glomerulonephritis

Anatomical Context for Crescentic Glomerulonephritis

MalaCards organs/tissues related to Crescentic Glomerulonephritis:

42
Kidney, Neutrophil, Lung, T Cells, Thyroid, Endothelial, Monocytes

Publications for Crescentic Glomerulonephritis

Articles related to Crescentic Glomerulonephritis:

(show top 50) (show all 704)
# Title Authors Year
1
Anca negative pauci-immune crescentic glomerulonephritis and mixed connective tissue disease: a case study. ( 30897193 )
2019
2
OX40 ligand is inhibitory during the effector phase of crescentic glomerulonephritis. ( 29939347 )
2019
3
Antineutrophil cytoplasmic antibody and/or antiglomerular basement membrane antibody associated crescentic glomerulonephritis in combination with IgG4-related tubulointerstitial nephritis. ( 30183608 )
2019
4
Clinical outcomes in patients with biopsy-proved diabetic nephropathy compared to isolated lupus or crescentic glomerulonephritis. ( 30641169 )
2019
5
The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis. ( 30765734 )
2019
6
Plasmapheresis and corticosteroids in infective endocarditis-related crescentic glomerulonephritis. ( 30872338 )
2019
7
Role of CD8+ T cells in crescentic glomerulonephritis. ( 30879039 )
2019
8
Crescentic Glomerulonephritis and Membranous Nephropathy: An Unusual Association. ( 30983761 )
2019
9
Pauci-Immune Crescentic Glomerulonephritis due to Disseminated Histoplasmosis. ( 30993241 )
2019
10
Plasma exchange and rituximab treatments in primary membranous nephropathy combined with crescentic glomerulonephritis: A case report. ( 31045764 )
2019
11
Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis. ( 31053735 )
2019
12
A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis. ( 30541482 )
2018
13
CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis. ( 29276101 )
2018
14
Levamisole Induced Pauci Immune Focal Necrotizing and Crescentic Glomerulonephritis. ( 29292489 )
2018
15
18F-FDG PET/CT Imaging of Necrotizing Crescentic Glomerulonephritis With Anti-Glomerular Basement Membrane Disease. ( 29293138 )
2018
16
Hypocomplementemic Urticarial Vasculitis Syndrome With Crescentic Glomerulonephritis. ( 29406049 )
2018
17
Tuberculosis and pauci-immune crescentic glomerulonephritis. ( 29437730 )
2018
18
Pauci-immune crescentic glomerulonephritis in a patient with B-lymphocyte poly/autoreactivity. ( 29465375 )
2018
19
Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement. ( 29877285 )
2018
20
Pauci-immune Crescentic Glomerulonephritis in a Patient With Immunoglobulin A Nephropathy and Serum Antineutrophil Cytoplasmic Autoantibody Positivity. ( 29901005 )
2018
21
An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis. ( 29923438 )
2018
22
Primary membranous nephropathy presenting with crescentic glomerulonephritis 25 years after initial presentation: A case report
. ( 29932409 )
2018
23
Necrotizing Crescentic Glomerulonephritis Complicating Bivalvular Bacterial Endocarditis. ( 29942723 )
2018
24
ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis. ( 29998485 )
2018
25
Sarcoidosis with multiple organ involvement associated with necrotizing crescentic glomerulonephritis. ( 30152439 )
2018
26
An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis. ( 30152441 )
2018
27
The diagnostic dilemma of new-onset crescentic glomerulonephritis following pre-eclampsia. ( 30178741 )
2018
28
Anca-associated crescentic glomerulonephritis in a child with isolated renal involvement. ( 30199560 )
2018
29
Crescentic glomerulonephritis with anti-GBM antibody but no glomerular deposition. ( 30208856 )
2018
30
Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity. ( 30210883 )
2018
31
Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis. ( 30232205 )
2018
32
Bacterial endocarditis manifesting as autoimmune pulmonary renal syndrome: ANCA-associated lung hemorrhage and pauci-immune crescentic glomerulonephritis
. ( 30369400 )
2018
33
Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis. ( 30522766 )
2018
34
Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis. ( 30540988 )
2018
35
Cerebral venous sinus thrombosis as a warning signal for double positive crescentic glomerulonephritis in a young male with complete renal recovery. ( 30588984 )
2018
36
ANCA-positive crescentic glomerulonephritis in a patient with rheumatoid arthritis treated with anti-tumor necrosis factor alpha. ( 26012729 )
2017
37
A Case of Crescentic Glomerulonephritis Complicated with Hypocomplementemic Urticarial Vasculitis Syndrome and ANCA-Associated Vasculitis. ( 29594143 )
2017
38
Anti-CD20 therapy and pauci-immune crescentic glomerulonephritis. ( 26786252 )
2017
39
A rare case of concurrent myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated necrotising and crescentic glomerulonephritis and membranous glomerulonephritis. ( 27931720 )
2017
40
Glomerular disease: Crescentic glomerulonephritis: beyond the immune system. ( 28298632 )
2017
41
The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation. ( 28326083 )
2017
42
Fibrillary glomerulonephritis presenting as crescentic glomerulonephritis. ( 28356674 )
2017
43
Complement activation in pauci-immune necrotizing and crescentic glomerulonephritis: results of a proteomic analysis. ( 28391334 )
2017
44
The Regulatory T-cell Transcription Factor Foxp3 Protects against Crescentic Glomerulonephritis. ( 28469165 )
2017
45
MPO-C-ANCA-associated necrotising and crescentic glomerulonephritis. ( 28491331 )
2017
46
Concurrent IgG4-related tubulointerstitial nephritis and IgG4 myeloperoxidase-anti-neutrophil cytoplasmic antibody positive crescentic glomerulonephritis: A case report. ( 28514287 )
2017
47
MMP2 and MMP9 associate with crescentic glomerulonephritis. ( 28584626 )
2017
48
Medullary angiitis and pauci-immune crescentic glomerulonephritis. ( 28670084 )
2017
49
Crescentic Glomerulonephritis With Immunoglobulin G4-Related Disease. ( 28918828 )
2017
50
Primary Sjögren's syndrome complicated by anti-neutrophil cytoplasmic antibody-mediated crescentic glomerulonephritis. ( 28937084 )
2017

Variations for Crescentic Glomerulonephritis

ClinVar genetic disease variations for Crescentic Glomerulonephritis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CEL NM_001807.4(CEL): c.1975G> C (p.Ala659Pro) single nucleotide variant Uncertain significance rs587780309 GRCh37 Chromosome 9, 135946855: 135946855
2 CEL NM_001807.4(CEL): c.1975G> C (p.Ala659Pro) single nucleotide variant Uncertain significance rs587780309 GRCh38 Chromosome 9, 133071468: 133071468

Expression for Crescentic Glomerulonephritis

Search GEO for disease gene expression data for Crescentic Glomerulonephritis.

Pathways for Crescentic Glomerulonephritis

Pathways related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 CTSG ICAM1 SERPINE1 VCAM1
2
Show member pathways
12.2 CCL2 ICAM1 SELE VCAM1
3
Show member pathways
12.11 CCL2 ICAM1 MPO SERPINE1
4 11.89 ICAM1 SELE VCAM1
5 11.81 CCL2 ICAM1 SELE VCAM1
6 11.8 ICAM1 SERPINE1 VCAM1
7 11.76 CCL2 ICAM1 VCAM1
8 11.66 CCL2 ICAM1 SELE VCAM1
9
Show member pathways
11.47 ICAM1 SELE VCAM1
10 11.43 NPHS2 PTPRO SYNPO WT1
11 11.35 CCL2 ICAM1 SELE SERPINE1 VCAM1
12 11.32 CCL2 CCR5 ICAM1
13 11.26 ICAM1 SELE VCAM1
14 11.15 ICAM1 SELE VCAM1
15 11.15 CCL2 ICAM1 SELE VCAM1
16 10.97 CCL2 ICAM1
17 10.13 CCL2 ICAM1 MPO VCAM1

GO Terms for Crescentic Glomerulonephritis

Cellular components related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.85 CCR5 ICAM1 NPHS2 PTPRO SELE VCAM1
2 extracellular exosome GO:0070062 9.56 BPI CTSG ICAM1 MPO NPHS2 PTPRO
3 cell surface GO:0009986 9.55 CCR5 CTSG ICAM1 TFPI VCAM1
4 azurophil granule lumen GO:0035578 9.43 BPI CTSG MPO
5 extracellular space GO:0005615 9.28 BPI CCL2 CTSG ICAM1 MPO SELE
6 plasma membrane GO:0005886 10.02 CCR5 CTSG ICAM1 NPHS2 PTPRO SELE

Biological processes related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.87 BPI CCL2 CCR5 CTSG
2 cytokine-mediated signaling pathway GO:0019221 9.8 CCL2 CCR5 ICAM1 VCAM1
3 cellular response to tumor necrosis factor GO:0071356 9.72 CCL2 ICAM1 VCAM1
4 cell chemotaxis GO:0060326 9.65 CCL2 CCR5 VCAM1
5 defense response to Gram-negative bacterium GO:0050829 9.63 BPI CTSG SERPINE1
6 cellular response to interleukin-1 GO:0071347 9.61 CCL2 ICAM1 TFPI
7 defense response to fungus GO:0050832 9.56 CTSG MPO
8 leukocyte tethering or rolling GO:0050901 9.54 SELE VCAM1
9 negative regulation of blood coagulation GO:0030195 9.52 SERPINE1 TFPI
10 negative regulation of growth of symbiont in host GO:0044130 9.51 CTSG MPO
11 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.43 ICAM1 SELE VCAM1
12 response to lipopolysaccharide GO:0032496 9.43 CTSG ICAM1 MPO SELE TFPI VCAM1
13 glomerulus development GO:0032835 9.4 PTPRO WT1
14 glomerular visceral epithelial cell differentiation GO:0072112 9.37 PTPRO WT1
15 leukocyte cell-cell adhesion GO:0007159 9.33 ICAM1 SELE VCAM1
16 membrane to membrane docking GO:0022614 9.32 ICAM1 VCAM1
17 cellular response to lipopolysaccharide GO:0071222 9.1 CCL2 CCR5 CTSG ICAM1 SERPINE1 TFPI

Sources for Crescentic Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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