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MCID: CRS001
MIFTS: 43

Crescentic Glomerulonephritis

Categories: Nephrological diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Crescentic Glomerulonephritis

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MalaCards integrated aliases for Crescentic Glomerulonephritis:

Name: Crescentic Glomerulonephritis 12 6 15
Idiopathic Crescentic Glomerulonephritis 71

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13139
NCIt 49 C128143
SNOMED-CT 67 236398000
UMLS 71 C0403416
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Summaries for Crescentic Glomerulonephritis

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MalaCards based summary : Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to rapidly progressive glomerulonephritis and goodpasture syndrome. An important gene associated with Crescentic Glomerulonephritis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Clemastine and rituximab have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, kidney and t cells, and related phenotypes are cardiovascular system and hematopoietic system

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Related Diseases for Crescentic Glomerulonephritis

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Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 392)
# Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 34.1 PRTN3 MPO ICAM1
2 goodpasture syndrome 33.3 VCAM1 PRTN3 MPO
3 pauci-immune glomerulonephritis 32.4 SYNPO CCN2
4 anca-associated vasculitis 31.7 PRTN3 MPO
5 anti-basement membrane glomerulonephritis 31.4 PRTN3 MPO
6 polyarteritis nodosa 31.1 VCAM1 PRTN3 MPO ICAM1
7 endocarditis 31.1 VCAM1 SERPINE1 CCL4
8 membranous nephropathy 31.1 WT1 NPHS2 MPO LCN2
9 mesangial proliferative glomerulonephritis 31.0 CCR5 CCL3 CCL2
10 proliferative glomerulonephritis 31.0 MPO CCR5 CCN2 CCL3 CCL2
11 immune-complex glomerulonephritis 31.0 VCAM1 MPO ICAM1 CCR5
12 henoch-schoenlein purpura 30.9 VCAM1 PRTN3 MPO ICAM1
13 pulmonary hemosiderosis 30.9 PRTN3 MPO
14 nephrotic syndrome 30.8 WT1 SYNPO PTPRO NPHS2 ACTN4
15 rheumatoid vasculitis 30.7 VCAM1 ICAM1
16 ileus 30.7 ICAM1 CCL3 CCL2
17 vasculitis 30.7 VCAM1 PRTN3 MPO LCN2 ICAM1 CTSG
18 pulmonary tuberculosis 30.5 CCL4 CCL3 CCL2
19 bronchiectasis 30.5 MPO CTSG BPI
20 subacute bacterial endocarditis 30.4 PRTN3 MPO
21 proteasome-associated autoinflammatory syndrome 1 30.4 VCAM1 MPO ICAM1 CCL3 CCL2
22 glomerulonephritis 30.4 VCAM1 SCGB1A1 PRTN3 NPHS2 MPO LCN2
23 granulomatosis with polyangiitis 30.4 PRTN3 MPO CTSG CCR5 BPI
24 pulmonary sarcoidosis 30.4 ICAM1 CCR5 CCL3 CCL2
25 uveitis 30.3 ICAM1 CCR5 CCL4 CCL2
26 meningitis 30.3 ICAM1 CCL4 CCL3 CCL2
27 nephrotic syndrome, type 1 30.2 WT1 NPHS2 ACTN4
28 focal segmental glomerulosclerosis 30.2 WT1 SYNPO PTPRO NPHS2 ACTN4
29 lipoid nephrosis 30.2 SYNPO NPHS2 CCL2 ACTN4
30 iga nephropathy 1 30.2 SCGB1A1 NPHS2
31 interstitial lung disease 30.1 SERPINE1 PRTN3 ICAM1 CCL2
32 sarcoidosis 1 30.1 SCGB1A1 ICAM1 CCR5 CCL4 CCL3 CCL2
33 nephrosclerosis 30.0 SYNPO NPHS2 MPO CCN2 CCL2
34 vascular disease 29.9 VCAM1 SERPINE1 MPO ICAM1 CCL2
35 pulmonary fibrosis 29.9 SERPINE1 MPO CCN2 CCL3 CCL2
36 arteriosclerosis 29.9 VCAM1 SERPINE1 ICAM1 CCR5 CCL2
37 allergic rhinitis 29.9 VCAM1 SCGB1A1 MPO ICAM1
38 wilms tumor 1 29.9 WT1 SYNPO NPHS2 CCN2
39 acute proliferative glomerulonephritis 29.9 SYNPO PRTN3 NPHS2 MPO CTSG CCL2
40 rheumatoid arthritis 29.8 VCAM1 PRTN3 MPO ICAM1 CTSG CCR5
41 familial nephrotic syndrome 29.6 WT1 SYNPO PTPRO NPHS2 ACTN4
42 kidney disease 29.6 WT1 VCAM1 SERPINE1 PRTN3 NPHS2 LCN2
43 systemic lupus erythematosus 29.0 VCAM1 SERPINE1 PRTN3 MPO LCN2 ICAM1
44 lung disease 28.8 SCGB1A1 PRTN3 MPO ICAM1 CTSG CCR5
45 chronic kidney disease 28.6 WT1 VCAM1 SERPINE1 NPHS2 MPO LCN2
46 malaria 28.6 VCAM1 SERPINE1 PRTN3 MPO LCN2 ICAM1
47 microscopic polyangiitis 11.8
48 end stage renal disease 10.7
49 acute kidney failure 10.7
50 purpura 10.6

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to Crescentic Glomerulonephritis
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Symptoms & Phenotypes for Crescentic Glomerulonephritis

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MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ACTN4 CCN2 CCR5 ICAM1 LCN2 MPO
2 hematopoietic system MP:0005397 10.06 ACTN4 CCR5 CTSG ICAM1 LCN2 MPO
3 immune system MP:0005387 10.03 ACTN4 CCL2 CCR5 CTSG ICAM1 LCN2
4 liver/biliary system MP:0005370 9.7 ACTN4 CCN2 CCR5 CTSG LCN2 SERPINE1
5 neoplasm MP:0002006 9.5 ACTN4 CCR5 CTSG ICAM1 SCGB1A1 SERPINE1
6 renal/urinary system MP:0005367 9.23 ACTN4 LCN2 NPHS2 PTPRO SCGB1A1 SERPINE1
Sources

Drugs & Therapeutics for Crescentic Glomerulonephritis

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Drugs for Crescentic Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clemastine Approved, Investigational Phase 3 15686-51-8 26987
2
rituximab Approved Phase 3 174722-31-7 10201696
3
Acetaminophen Approved Phase 3 103-90-2 1983
4
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
5
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
7
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
8
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
9
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
10
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
11 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
12
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
13
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
14 Immunologic Factors Phase 3
15 Immunoglobulins Phase 3
16 Antibodies Phase 3
17 Alkylating Agents Phase 3
18 Antirheumatic Agents Phase 3
19 Antineoplastic Agents, Immunological Phase 3
20 Antiemetics Phase 2, Phase 3
21 Immunoglobulin A Phase 2, Phase 3
22 Gastrointestinal Agents Phase 2, Phase 3
23 Immunosuppressive Agents Phase 3
24 Protective Agents Phase 3
25 Hormones Phase 3
26 Antineoplastic Agents, Hormonal Phase 3
27 Methylprednisolone Acetate Phase 3
28 Hormone Antagonists Phase 3
29 Neuroprotective Agents Phase 3
30 glucocorticoids Phase 3
31 Anti-Inflammatory Agents Phase 3
32 Phosphodiesterase Inhibitors Phase 3
33 Antioxidants Phase 3
34 Platelet Aggregation Inhibitors Phase 3
35 Vasodilator Agents Phase 3
36 Radiation-Protective Agents Phase 3
37
Lisinopril Approved, Investigational Phase 2 76547-98-3, 83915-83-7 5362119
38 Cardiotonic Agents Phase 2
39 Antihypertensive Agents Phase 2
40 Angiotensin-Converting Enzyme Inhibitors Phase 2
41
protease inhibitors Phase 2
42 HIV Protease Inhibitors Phase 2
43 Complement System Proteins
44 Antistreptolysin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoadsorption in Anti-glomerular Basement Membrane Glomerulonephritis; a Pilot Study Recruiting NCT02765789 Phase 4
2 Evaluating Favorable, Immunological Effects of Rituximab With Cyclophosphamide Compared to Rituximab Alone in AAV Patients Recruiting NCT03942887 Phase 3 Rituximab;endoxan;Methylprednisolone;Prednisolone
3 Randomized Trial of Plasma Exchange as Adjunctive Therapy for Severe Crescentic GlomerUlonephritis of IgA NEphropathy (RESCUE Study) Enrolling by invitation NCT02647255 Phase 2, Phase 3 Methylprednisolone pulse
4 Clinical Efficacy of Combined Pentoxifylline and Conventional Immunosuppressive Regimens on Patients With Rapidly Progressive Glomerulonephritis Terminated NCT00354198 Phase 3 pentoxifylline;corticosteroids
5 A Pilot, Prospective, Randomized, Open-label, Blinded Endpoint (Probe) Histopathology Trial to Assess the Effects of ACE- Inhibition Therapy on Glomerular Proliferative Lesions in Patients With Extracapillary Glomerulonephritis Unknown status NCT02682459 Phase 2 Lisinopril
6 Clinical Spectrum and Outcome of Acute Post Streptococcal Glomerulonephritis in Children . Unknown status NCT03184103
7 Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN) Screening in Systemic Lupus Erythematosus (SLE) Patients? Completed NCT03664908

Search NIH Clinical Center for Crescentic Glomerulonephritis

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Genetic Tests for Crescentic Glomerulonephritis

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Anatomical Context for Crescentic Glomerulonephritis

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MalaCards organs/tissues related to Crescentic Glomerulonephritis:

40
Neutrophil, Kidney, T Cells, Lung, Monocytes, Endothelial, Testes
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Publications for Crescentic Glomerulonephritis

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Articles related to Crescentic Glomerulonephritis:

(show top 50) (show all 1817)
# Title Authors PMID Year
1
Rapidly progressive glomerulonephritis and acute kidney injury associated with cocaine use - Case report. 61
32573647 2020
2
Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model. 61
32305129 2020
3
The glomerular crescent: triggers, evolution, resolution, and implications for therapy. 61
32132388 2020
4
Crescentic glomerulonephritis in children. 61
32052153 2020
5
Narrative Review of Hypercoagulability in Small-Vessel Vasculitis. 61
32405580 2020
6
Antibody-mediated rejection with the presence of glomerular crescents in a pediatric kidney transplant recipient: A case report. 61
32437064 2020
7
Parietal epithelial cells role in repair versus scarring after glomerular injury. 61
32235272 2020
8
Update on the etiology, classification, and management of glomerular diseases. 61
32500044 2020
9
Role of CD8+ T cells in crescentic glomerulonephritis. 61
30879039 2020
10
Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases. 61
32317520 2020
11
Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings. 61
32296530 2020
12
Patterns in renal diseases diagnosed by kidney biopsy: A single-center experience. 61
31955562 2020
13
Utility of immunohistochemistry with C3d in C3 glomerulopathy. 61
31477814 2020
14
Rare case of post-varicella membranoproliferative glomerulonephritis presenting with massive proteinuria. 61
32169983 2020
15
The Presence of Renal IgG Deposits in Necrotizing Crescentic Glomerulonephritis Associated with ANCA Is Not Related to Worse Renal Clinical Outcomes. 61
32309292 2020
16
De novo pauci-immune glomerulonephritis in renal allografts. 61
31477812 2020
17
Resolution of syphilis-related rapidly progressive glomerulonephritis with penicillin therapy: Case report
. 61
31813414 2020
18
Autoimmune polyglandular syndrome type III associated with antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis: A case report and literature review. 61
32049851 2020
19
Crescentic IgA nephropathy after administration of human monoclonal interleukin-12/23p40 antibody in a patient with Crohn's disease: a case report. 61
32100251 2020
20
A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings. 61
32509365 2020
21
Lupus Nephritis Class IV-Global Is Associated with a Higher Risk of End-Stage Renal Disease than Class IV-Segmental. 61
31910408 2020
22
Granulomatous Interstitial Nephritis - A Series of Six Cases. 61
32015596 2020
23
Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats. 61
32146474 2020
24
Predictors of renal outcomes in anti-neutrophil cytoplasmic antibody glomerulonephritis. 61
32129212 2020
25
Paraneoplastic ANCA positive crescentic glomerulonephritis as presenting feature of Mantle Cell lymphoma a unique case. 61
31979746 2020
26
Successful simultaneous liver-kidney transplantation for renal failure associated with hereditary complement C3 deficiency. 61
31970896 2020
27
Diagnostic and treatment challenge of unrecognized subacute bacterial endocarditis associated with ANCA-PR3 positive immunocomplex glomerulonephritis: a case report and literature review. 61
32005179 2020
28
Intravenous (IV) cefazolin with oral probenecid: A novel daily regimen for the management of Methicillin Sensitive Staphylococcus aureus (MSSA) bacteremia in a patient with renal dysfunction. 61
32055441 2020
29
Complement alternative pathway in ANCA-associated vasculitis: Two decades from bench to bedside. 61
31734405 2020
30
Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report. 61
32274231 2020
31
Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis complicated by infectious endocarditis: a case report. 61
31801609 2019
32
Concurrent treatment with rituximab and plasma exchange for severe refractory granulomatosis with polyangiitis: A case report. 61
31860960 2019
33
The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease. 61
31563334 2019
34
CMV gastric ulcer in a patient with pauci immune crescentic glomerulonephritis on rituximab - a rare combination. 61
31506001 2019
35
Membranous Glomerulonephritis With Crescents. 61
31890999 2019
36
Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy. 61
31525832 2019
37
Etiopathological Study of Crescentic Glomerulonephritis and its Outcome: A Retrospective Analysis. 61
31793263 2019
38
Clinicopathological features and prognostic analysis of 49 cases with crescentic glomerulonephritis. 61
31611938 2019
39
The role of mammalian target of rapamycin pathway in the pathogenesis of pauci-immune glomerulonephritis. 61
31658846 2019
40
Pauci-immune Crescentic Glomerulonephritis Due to MGRS Crystalline Nephropathy. 61
31701064 2019
41
Membranous nephropathy in a child with crescentic glomerulonephritis: Coincidence or comorbidity? 61
31696856 2019
42
Role of prognostic biomarker decoy receptor 3 and immunomodulation in kidney diseases. 61
31356560 2019
43
Prognostic factors in glomerular diseases with crescents. 61
31075086 2019
44
Recurrent anti-GBM disease with T-cell large granular lymphocytic leukemia: A case report. 61
31374037 2019
45
Vasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice. 61
31476889 2019
46
Predicting long-term renal and patient survival by clinicopathological features in elderly patients undergoing a renal biopsy in a UK cohort. 61
31384442 2019
47
Rare but not beyond care: a young female with altered mental status and seizures. 61
31398723 2019
48
A case report of immunoglobulin M nephropathy manifesting as crescentic glomerulonephritis and nephrotic syndrome in an adult. 61
31455257 2019
49
Rare case of atypical crescentic glomerulonephritis and interstitial lung disease with negative anti-GBM antibody and positive anti-MPO antibody. 61
31371277 2019
50
Urine macrophages reflect kidney macrophage content during acute tubular interstitial and glomerular injury. 61
31212026 2019
Sources

Variations for Crescentic Glomerulonephritis

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ClinVar genetic disease variations for Crescentic Glomerulonephritis:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CEL NM_001807.5(CEL):c.1966G>C (p.Ala656Pro)SNV Uncertain significance 128688 rs587780309 9:135946855-135946855 9:133071468-133071468
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Expression for Crescentic Glomerulonephritis

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Search GEO for disease gene expression data for Crescentic Glomerulonephritis.
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Pathways for Crescentic Glomerulonephritis

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Pathways related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.83 VCAM1 TNFRSF6B PRTN3 MPO LCN2 ICAM1
2
Integrin Pathway 63
Show member pathways
 13.25 VCAM1 SERPINE1 ICAM1 CCR5 CCL4 CCL3
3
PAK Pathway 63
Show member pathways
 13.12 PTPRO CCR5 CCN2 CCL4 CCL3 CCL2
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.08 VCAM1 TNFRSF6B PRTN3 LCN2 ICAM1 CCR5
5
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.18 CCR5 CCL4 CCL3 CCL2
6
Folate Metabolism 1
Show member pathways
 12.17 SERPINE1 MPO ICAM1 CCL2
7
Defensins 65
Show member pathways
 12.16 PRTN3 LCN2 CTSG BPI
8
Adhesion 4
11.82 VCAM1 SERPINE1 ICAM1 CCN2
9
NF-kappa B signaling pathway 36
11.77 VCAM1 ICAM1 CCL4
10
Interleukin-4 and 13 signaling 65
11.76 VCAM1 LCN2 ICAM1 CCL2
11
Rheumatoid arthritis 36
11.7 ICAM1 CCL3 CCL2
12
AGE-RAGE signaling pathway in diabetic complications 36
11.67 VCAM1 SERPINE1 ICAM1 CCL2
13
Primary Focal Segmental Glomerulosclerosis FSGS 1
11.42 WT1 SYNPO PTPRO NPHS2 ACTN4
14
Malaria 36
11.37 VCAM1 ICAM1 CCL2
15
Lung fibrosis 1
11.36 CCN2 CCL4 CCL3 CCL2
16
amb2 Integrin signaling 1
11.33 MPO ICAM1 CCN2
17
Interleukin-10 signaling 65
11.04 ICAM1 CCR5 CCL4 CCL3 CCL2
18
LDL Oxidation in Atherogenesis 63
10.23 VCAM1 MPO ICAM1 CCL3 CCL2
Sources

GO Terms for Crescentic Glomerulonephritis

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Cellular components related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.93 VCAM1 SERPINE1 SCGB1A1 PTPRO PRTN3 NPHS2
2 cell GO:0005623 9.91 MPO LCN2 ICAM1 CCR5 CCL3 CCL2
3 extracellular region GO:0005576 9.77 TNFRSF6B SERPINE1 SCGB1A1 PRTN3 MPO LCN2
4 collagen-containing extracellular matrix GO:0062023 9.72 SERPINE1 PRTN3 ICAM1 CTSG CCN2
5 secretory granule GO:0030141 9.58 SCGB1A1 MPO CTSG
6 azurophil granule lumen GO:0035578 9.56 PRTN3 MPO CTSG BPI
7 extracellular space GO:0005615 9.5 VCAM1 TNFRSF6B SERPINE1 SCGB1A1 PRTN3 MPO

Biological processes related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 10.02 PRTN3 MPO LCN2 CTSG BPI
2 immune response GO:0006955 9.97 CTSG CCR5 CCL4 CCL3 CCL2 BPI
3 defense response to bacterium GO:0042742 9.95 MPO LCN2 CTSG BPI
4 positive regulation of GTPase activity GO:0043547 9.93 PRTN3 ICAM1 CCL4 CCL3 CCL2
5 response to lipopolysaccharide GO:0032496 9.87 SCGB1A1 MPO ICAM1 CTSG
6 chemotaxis GO:0006935 9.86 CCR5 CCL4 CCL3 CCL2
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 ICAM1 CCN2 CCL4 CCL3 CCL2
8 cell chemotaxis GO:0060326 9.82 CCR5 CCL3 CCL2
9 defense response to Gram-negative bacterium GO:0050829 9.81 SERPINE1 CTSG BPI
10 neutrophil chemotaxis GO:0030593 9.8 CCL4 CCL3 CCL2
11 cellular response to interferon-gamma GO:0071346 9.78 ICAM1 CCL4 CCL3 CCL2
12 cellular response to tumor necrosis factor GO:0071356 9.72 LCN2 ICAM1 CCL4 CCL3 CCL2
13 chemokine-mediated signaling pathway GO:0070098 9.71 CCR5 CCL4 CCL3 CCL2
14 lymphocyte chemotaxis GO:0048247 9.7 CCL4 CCL3 CCL2
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 CCL3 CCL2 BPI
16 antimicrobial humoral response GO:0019730 9.67 PRTN3 LCN2 CTSG BPI
17 macrophage chemotaxis GO:0048246 9.65 CCL3 CCL2
18 cellular response to nutrient levels GO:0031669 9.65 LCN2 ICAM1
19 negative regulation by host of viral transcription GO:0043922 9.63 CCL4 CCL3
20 eosinophil chemotaxis GO:0048245 9.63 CCL4 CCL3 CCL2
21 response to cholesterol GO:0070723 9.62 CCR5 CCL3
22 glomerulus development GO:0032835 9.61 WT1 PTPRO
23 signaling GO:0023052 9.61 CCR5 CCL3
24 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.6 CCR5 CCL3
25 glomerular visceral epithelial cell differentiation GO:0072112 9.59 WT1 PTPRO
26 positive regulation of natural killer cell chemotaxis GO:2000503 9.58 CCL4 CCL3
27 astrocyte cell migration GO:0043615 9.58 CCL3 CCL2
28 monocyte chemotaxis GO:0002548 9.56 PTPRO CCL4 CCL3 CCL2
29 membrane to membrane docking GO:0022614 9.55 VCAM1 ICAM1
30 cellular response to interleukin-1 GO:0071347 9.55 LCN2 ICAM1 CCL4 CCL3 CCL2
31 cellular response to lipopolysaccharide GO:0071222 9.43 SERPINE1 LCN2 ICAM1 CTSG CCR5 CCL2
32 cytokine-mediated signaling pathway GO:0019221 9.23 VCAM1 PRTN3 LCN2 ICAM1 CCR5 CCL4

Molecular functions related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.43 CCL4 CCL3 CCL2
2 CCR5 chemokine receptor binding GO:0031730 9.32 CCL4 CCL3
3 integrin binding GO:0005178 9.26 VCAM1 ICAM1 CCN2 ACTN4
4 CCR1 chemokine receptor binding GO:0031726 9.16 CCL4 CCL3
5 CCR chemokine receptor binding GO:0048020 8.8 CCL4 CCL3 CCL2
Sources

Sources for Crescentic Glomerulonephritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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