MCID: CRB006
MIFTS: 46

Cribriform Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Cribriform Carcinoma

MalaCards integrated aliases for Cribriform Carcinoma:

Name: Cribriform Carcinoma 12 15 17
Ductal Carcinoma, Cribriform Type 12
Carcinoma, Cribriform 74
Carcinoma Cribriform 56

Classifications:



External Ids:

Disease Ontology 12 DOID:5675
MeSH 45 D000230
NCIt 51 C3680
SNOMED-CT 69 30156004
UMLS 74 C0205643

Summaries for Cribriform Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by an irregular cribriform growth pattern, nuclear grade I in at least 90% of cells, and absent myoepithelial cells.

MalaCards based summary : Cribriform Carcinoma, also known as ductal carcinoma, cribriform type, is related to adenoid cystic carcinoma and papillary carcinoma. An important gene associated with Cribriform Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Innate Lymphoid Cell Differentiation Pathways. The drugs Fentanyl and Diphenhydramine have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related phenotypes are Decreased viability in esophageal squamous lineage and cellular

Related Diseases for Cribriform Carcinoma

Diseases related to Cribriform Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 31.0 KIT KRT7 PGR TP63
2 papillary carcinoma 29.8 KRT7 PGR
3 benign breast phyllodes tumor 29.5 KIT PGR TP63
4 thyroid cancer, nonmedullary, 1 10.4
5 thyroid cancer 10.3
6 bartholin's gland disease 10.2 GATA3 PGR
7 gastric signet ring cell adenocarcinoma 10.2 GATA3 PGR
8 inverted transitional papilloma 10.2 GATA3 KRT7
9 sarcomatoid renal cell carcinoma 10.2 GATA3 KIT
10 embryoma 10.2 GATA3 KIT
11 eccrine papillary adenocarcinoma 10.2 KRT7 PGR
12 papillary adenocarcinoma 10.2 KRT7 PGR
13 endosalpingiosis 10.2 KRT7 PGR
14 benign metastasizing leiomyoma 10.2 KRT7 PGR
15 pancreatic serous cystadenoma 10.2 KRT7 PGR
16 cystadenoma 10.2 KRT7 PGR
17 corneal abscess 10.2 KRT7 PGR
18 papillary serous adenocarcinoma 10.2 KRT7 PGR
19 cystic nephroma 10.2 KIT PGR
20 perivascular epithelioid cell tumor 10.2 KIT PGR
21 cystitis cystica 10.2 GATA3 KRT7
22 papillary hidradenoma 10.2 KIT PGR
23 sertoli-leydig cell tumor 10.2 KRT7 PGR
24 sclerosing hemangioma 10.2 KRT7 PGR
25 breast secretory carcinoma 10.2 KRT7 PGR
26 ceruminoma 10.2 KIT KRT7
27 jejunal cancer 10.2 KIT KRT7
28 pancreatic mucinous cystadenoma 10.1 KRT7 PGR
29 leiomyomatosis 10.1 ESR1 PGR
30 myoma 10.1 ESR1 PGR
31 sweat gland disease 10.1 KRT7 PGR
32 intratubular embryonal carcinoma 10.1 KIT KRT7
33 malignant leydig cell tumor 10.1 KIT KRT7
34 vestibular gland benign neoplasm 10.1 ESR1 PGR
35 bartholin's gland adenoma 10.1 ESR1 PGR
36 vulvar syringoma 10.1 ESR1 PGR
37 lung leiomyoma 10.1 ESR1 PGR
38 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
39 vulvar benign neoplasm 10.1 ESR1 PGR
40 trigonitis 10.1 ESR1 PGR
41 vulvar leiomyoma 10.1 ESR1 PGR
42 predominantly cortical thymoma 10.1 ESR1 PGR
43 breast medullary carcinoma 10.1 ESR1 PGR
44 breast scirrhous carcinoma 10.1 ESR1 PGR
45 bartholin's gland benign neoplasm 10.1 ESR1 PGR
46 progesterone-receptor positive breast cancer 10.1 ESR1 PGR
47 dysgerminoma of ovary 10.1 KIT PGR
48 progesterone resistance 10.1 ESR1 PGR
49 endometrial squamous cell carcinoma 10.1 ESR1 PGR
50 warthin tumor 10.1 KIT KRT7

Graphical network of the top 20 diseases related to Cribriform Carcinoma:



Diseases related to Cribriform Carcinoma

Symptoms & Phenotypes for Cribriform Carcinoma

GenomeRNAi Phenotypes related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.02 ESR1 KIT KRT7 PGR TP63

MGI Mouse Phenotypes related to Cribriform Carcinoma:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 ESR1 GATA3 KIT KRT7 PGR TP63
2 cardiovascular system MP:0005385 9.95 ESR1 GATA3 KIT PGR TP63
3 homeostasis/metabolism MP:0005376 9.95 ESR1 GATA3 KIT KRT7 PGR TP63
4 embryo MP:0005380 9.91 ESR1 GATA3 KIT PGR TP63
5 endocrine/exocrine gland MP:0005379 9.89 ESR1 GATA3 KIT PGR TP63
6 integument MP:0010771 9.85 ESR1 GATA3 KIT PGR TP63
7 digestive/alimentary MP:0005381 9.83 ESR1 GATA3 KIT TP63
8 muscle MP:0005369 9.8 ESR1 GATA3 KIT PGR TP63
9 limbs/digits/tail MP:0005371 9.73 ESR1 KIT PGR TP63
10 no phenotypic analysis MP:0003012 9.72 ESR1 GATA3 KIT PGR TP63
11 neoplasm MP:0002006 9.67 ESR1 KIT PGR TP63
12 normal MP:0002873 9.65 ESR1 GATA3 KIT PGR TP63
13 renal/urinary system MP:0005367 9.55 ESR1 GATA3 KIT KRT7 TP63
14 reproductive system MP:0005389 9.35 ESR1 GATA3 KIT PGR TP63
15 skeleton MP:0005390 9.02 ESR1 GATA3 KIT PGR TP63

Drugs & Therapeutics for Cribriform Carcinoma

Drugs for Cribriform Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
3
Promethazine Approved, Investigational Phase 3 60-87-7 4927
4
Doxepin Approved, Investigational Phase 3 1668-19-5 667468 667477
5
Histamine Approved, Investigational Phase 3 51-45-6 774
6
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 22916-47-8 4189
7
Fluconazole Approved, Investigational Phase 2, Phase 3 86386-73-4 3365
8
Cevimeline Approved Phase 3 107233-08-9 83898 25137844
9
Megestrol acetate Approved, Investigational, Vet_approved Phase 3 595-33-5 11683
10
Docetaxel Approved, Investigational Phase 3,Phase 1,Phase 2 114977-28-5 148124
11 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
12 Porfiromycin Investigational Phase 3 801-52-5
13 Cola Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Liver Extracts Phase 3,Phase 2,Phase 1,Early Phase 1
15 Anti-Infective Agents Phase 2, Phase 3,Phase 1
16 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
17 Central Nervous System Depressants Phase 3
18 Peripheral Nervous System Agents Phase 3,Not Applicable
19 Analgesics, Opioid Phase 3
20 Anesthetics Phase 3
21 Anesthetics, Intravenous Phase 3
22 Narcotics Phase 3
23 Adjuvants, Anesthesia Phase 3
24 Analgesics Phase 3
25 Anesthetics, General Phase 3
26 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
28 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
29 Mitomycins Phase 3
30 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
31 Antidepressive Agents Phase 3
32
Histamine Phosphate Phase 3 51-74-1 65513
33 Neurotransmitter Agents Phase 3,Not Applicable
34 Psychotropic Drugs Phase 3
35 Antidepressive Agents, Tricyclic Phase 3
36 Histamine Antagonists Phase 3
37 Hypnotics and Sedatives Phase 3
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
39 Antifungal Agents Phase 2, Phase 3,Phase 1
40 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
41 Hormone Antagonists Phase 2, Phase 3
42 Hormones Phase 2, Phase 3,Phase 1
43 Steroid Synthesis Inhibitors Phase 2, Phase 3
44 Cytochrome P-450 CYP2C19 Inhibitors Phase 2, Phase 3
45 Cholinergic Agents Phase 3,Not Applicable
46 Autonomic Agents Phase 3,Not Applicable
47 Muscarinic Agonists Phase 3
48 Appetite Stimulants Phase 3
49 Antineoplastic Agents, Hormonal Phase 3
50 Central Nervous System Stimulants Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer Completed NCT00002507 Phase 3 mitomycin C;porfiromycin
3 Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract Completed NCT00765440 Phase 3
4 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Completed NCT01156142 Phase 3 doxepin hydrochloride
5 Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer Completed NCT00090337 Phase 3
6 Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed NCT00002533 Phase 2, Phase 3 fluconazole
7 Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer Completed NCT00017511 Phase 3 cevimeline hydrochloride
8 Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer Completed NCT00006799 Phase 3 megestrol acetate
9 Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery Withdrawn NCT00041171 Phase 3 Hypericum perforatum;docetaxel
10 Study of Imatinib (Glivec) in Patients With Adenoid Cystic Carcinoma of the Head and Neck Unknown status NCT00180921 Phase 2 Imatinib
11 Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy Unknown status NCT01192087 Phase 1, Phase 2 Cetuximab
12 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
13 A Study of Sunitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands Completed NCT00886132 Phase 2 Sunitinib
14 Study of RAD001 in Adenoid Cystic Carcinoma Completed NCT01152840 Phase 2 RAD001
15 Phase II Trial of Doxorubicin and Bortezomib in Patients With Incurable Adenoid Cystic Carcinoma of the Head and Neck Completed NCT00581360 Phase 2 doxorubicin and bortezomib
16 Axitinib (AG-013736) in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma Completed NCT01558661 Phase 2 AG-013736 (AXITINIB)
17 Dovitinib in Adenoid Cystic Carcinoma Completed NCT01417143 Phase 2 TKI258 (Dovitinib):
18 Study of Dovitinib (TKI258) in Adenoid Cystic Carcinoma Completed NCT01524692 Phase 2 Dovitinib (TKI258)
19 A Phase II Study of Dovitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands Completed NCT01678105 Phase 2 Dovitinib
20 Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma Completed NCT01175980 Phase 2 Vorinostat
21 Bortezomib Followed by the Addition of Doxorubicin at Disease Progression in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma (Cancer) of the Head and Neck Completed NCT00077428 Phase 2 bortezomib;doxorubicin hydrochloride
22 Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers Completed NCT00095563 Phase 2 lapatinib ditosylate
23 Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors Completed NCT00859937 Phase 2 Dasatinib
24 Akt Inhibitor MK2206 in Treating Patients With Progressive, Recurrent, or Metastatic Adenoid Cyst Carcinoma Completed NCT01604772 Phase 2 Akt Inhibitor MK2206
25 Gemcitabine in Treating Patients With Recurrent or Metastatic Adenoid Cystic Cancer of the Head and Neck Completed NCT00017498 Phase 2 gemcitabine hydrochloride
26 Imatinib Mesylate in Treating Patients With Salivary Gland Cancer Completed NCT00045669 Phase 2 imatinib mesylate
27 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
28 Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer Completed NCT00101348 Phase 1, Phase 2 erlotinib hydrochloride
29 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
30 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
31 Docetaxel in Treating Patients With Solid Tumors Completed NCT00003565 Phase 2 docetaxel
32 Oxaliplatin and Capecitabine in Treating Patients With Relapsed or Metastatic Head and Neck Cancer Completed NCT00448552 Phase 2 capecitabine;oxaliplatin
33 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer Completed NCT00004901 Phase 1, Phase 2 ethynyluracil;fluorouracil;hydroxyurea
34 Epirubicin, Carboplatin, and Capecitabine in Treating Patients With Unresectable Locally Advanced, Metastatic, or Recurrent Solid Tumor Completed NCT00021047 Phase 1, Phase 2 capecitabine;carboplatin;epirubicin hydrochloride
35 Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors Completed NCT00019331 Phase 2 DetoxPC
36 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
37 Cisplatin or Carboplatin Combined With Gemcitabine in Treating Patients With Locally Advanced, Recurrent, or Metastatic Malignant Salivary Gland Tumor Completed NCT00079079 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride
38 Trastuzumab in Treating Patients With Advanced Salivary Gland Cancer Completed NCT00004163 Phase 2 Trastuzumab
39 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine
40 Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer Completed NCT00509665 Phase 2 doxorubicin hydrochloride;gemcitabine hydrochloride
41 Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer Completed NCT00021333 Phase 2 cisplatin;paclitaxel
42 Chidamide for Advanced Cephalic and Cervical Adenocystic Carcinoma: Evaluation of Efficiency and Safety Recruiting NCT02883374 Phase 2 Chidamide
43 Trail Evaluating Particle Therapy With or Without Apatinib for H&N Adenoid Cystic Carcinoma Recruiting NCT02942693 Phase 2 Apatinib
44 Chidamide Combined With Cisplatin in Head and Neck Adenoid Cystic Carcinoma (HNACC) Recruiting NCT03639168 Phase 2 Chidamide combined with cisplatin
45 A Study Of AL101 In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations Recruiting NCT03691207 Phase 2 AL101
46 Nivolumab and Ipilimumab in Treating Patients With Metastatic/Recurrent ACC of All Sites and Non-ACC Salivary Gland Cancer Recruiting NCT03146650 Phase 2
47 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
48 Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer Recruiting NCT03172624 Phase 2 Nivolumab;Ipilimumab
49 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
50 Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies Recruiting NCT03422679 Phase 1, Phase 2 CB-103

Search NIH Clinical Center for Cribriform Carcinoma

Genetic Tests for Cribriform Carcinoma

Anatomical Context for Cribriform Carcinoma

MalaCards organs/tissues related to Cribriform Carcinoma:

42
Salivary Gland, Breast, Lung, Brain, Skin, Liver, Kidney

Publications for Cribriform Carcinoma

Articles related to Cribriform Carcinoma:

(show all 36)
# Title Authors Year
1
GATA-3 staining in primary cutaneous apocrine cribriform carcinoma: usefulness To differentiate it from breast cancer metastasis. ( 29431200 )
2018
2
Role of MRI-targeted Biopsy in Detection of Prostate Cancer Harbouring Adverse Pathological Features of Intraductal Carcinoma and Invasive Cribriform Carcinoma. ( 29408568 )
2018
3
Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set. ( 30160779 )
2018
4
Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate. ( 30333152 )
2018
5
A solid variant of primary cutaneous cribriform carcinoma: a small, stable, long-term lesion. ( 28508756 )
2017
6
Primary Cribriform Carcinoma of the Eyelid With Neuroendocrine Features: A Case Report. ( 28300861 )
2017
7
Evaluation and comparison of radiologic-pathologic findings in invasive cribriform carcinoma of the breast. ( 28618754 )
2017
8
Primary Cutaneous Cribriform Carcinoma Treated With Mohs Micrographic Surgery. ( 28872559 )
2017
9
Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. ( 25789036 )
2015
10
Clinicopathological Characteristics and Survival Outcomes of Invasive Cribriform Carcinoma of Breast: A SEER Population-Based Study. ( 26252312 )
2015
11
Primary cutaneous cribriform carcinoma: report of six cases with clinicopathologic data and immunohistochemical profile. ( 25732813 )
2015
12
Colonic Cribriform Carcinoma, a Morphologic Pattern Associated With Low Survival. ( 25015669 )
2014
13
Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort. ( 24703897 )
2014
14
Invasive cribriform carcinoma of the breast: mammographic, sonographic, MRI, and 18a88F-FDG PET-CT features. ( 24938660 )
2014
15
Cribriform carcinoma mimicking breast abscess - case report. Diagnostic and therapeutic management. ( 26674469 )
2013
16
Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. ( 23412348 )
2013
17
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. ( 23110003 )
2012
18
Primary cutaneous cribriform carcinoma of the neck: a case report. ( 23316623 )
2012
19
A pure invasive cribriform carcinoma of the breast with bone metastasis if untreated for thirteen years: a case report and literature review. ( 23167837 )
2012
20
Cutaneous cribriform carcinoma: a short comment. ( 21315957 )
2011
21
Sonographic findings of invasive cribriform carcinoma of the breast. ( 21527619 )
2011
22
Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases. ( 18769339 )
2008
23
Grading of invasive cribriform carcinoma on prostate needle biopsy: an interobserver study among experts in genitourinary pathology. ( 18724248 )
2008
24
Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. ( 18085381 )
2007
25
Report on a case of pure cribriform carcinoma of the breast with internal mammary node metastasis: description of the case and review of the literature. ( 16869243 )
2006
26
Invasive cribriform carcinoma with extensive microcalcifications in the male breast. ( 15858447 )
2005
27
Primary cutaneous cribriform carcinoma: a rare apocrine tumour. ( 16115058 )
2005
28
A case report of cribriform carcinoma of the pancreas with long time survival. ( 11268983 )
2001
29
Fine needle aspiration cytology of invasive cribriform carcinoma of the breast with osteoclastlike giant cells: a case report. ( 11480724 )
2001
30
Cribriform carcinoma of the prostate and cribriform prostatic intraepithelial neoplasia: incidence and clinical implications. ( 9669346 )
1998
31
Infiltrating cribriform carcinoma of the breast. A clinico-pathologic and immunohistochemical study of 5 cases. ( 8780923 )
1996
32
Fine needle aspiration of invasive cribriform carcinoma with benign osteoclast-like giant cells of histiocytic origin. A case report. ( 8191846 )
1994
33
Light and electron microscopic study of an invasive cribriform carcinoma with extensive microcalcification developing in a breast with silicone augmentation. ( 7810003 )
1994
34
The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team. ( 7955831 )
1994
35
Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity. ( 2312110 )
1990
36
Invasive cribriform carcinoma of the breast. ( 6884999 )
1983

Variations for Cribriform Carcinoma

Expression for Cribriform Carcinoma

Search GEO for disease gene expression data for Cribriform Carcinoma.

Pathways for Cribriform Carcinoma

Pathways related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 ESR1 KIT PGR
2 11.16 GATA3 KIT
3 11.05 GATA3 KIT
4 10.84 ESR1 GATA3

GO Terms for Cribriform Carcinoma

Cellular components related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.8 ESR1 GATA3 TP63

Biological processes related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 ESR1 GATA3 PGR TP63
2 negative regulation of gene expression GO:0010629 9.67 ESR1 GATA3 PGR
3 response to estrogen GO:0043627 9.58 ESR1 GATA3
4 steroid hormone mediated signaling pathway GO:0043401 9.57 ESR1 PGR
5 positive regulation of Notch signaling pathway GO:0045747 9.56 KIT TP63
6 erythrocyte differentiation GO:0030218 9.54 GATA3 KIT
7 positive regulation of protein kinase B signaling GO:0051897 9.54 ESR1 GATA3 KIT
8 T cell differentiation GO:0030217 9.52 GATA3 KIT
9 stem cell differentiation GO:0048863 9.51 ESR1 KIT
10 anatomical structure formation involved in morphogenesis GO:0048646 9.48 GATA3 TP63
11 uterus development GO:0060065 9.46 ESR1 GATA3
12 embryonic hemopoiesis GO:0035162 9.43 GATA3 KIT
13 sympathetic nervous system development GO:0048485 9.4 GATA3 TP63
14 male gonad development GO:0008584 9.33 ESR1 GATA3 KIT
15 positive regulation of phospholipase C activity GO:0010863 9.32 ESR1 KIT
16 epithelial cell development GO:0002064 9.26 ESR1 TP63
17 chromatin remodeling GO:0006338 9.13 ESR1 GATA3 TP63
18 mast cell differentiation GO:0060374 8.62 GATA3 KIT

Molecular functions related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.58 ESR1 GATA3 PGR
2 DNA-binding transcription factor activity GO:0003700 9.46 ESR1 GATA3 PGR TP63
3 ATPase binding GO:0051117 9.43 ESR1 PGR
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.37 ESR1 KIT
5 steroid hormone receptor activity GO:0003707 9.32 ESR1 PGR
6 nuclear receptor activity GO:0004879 9.26 ESR1 PGR
7 steroid binding GO:0005496 8.96 ESR1 PGR
8 sequence-specific DNA binding GO:0043565 8.92 ESR1 GATA3 PGR TP63

Sources for Cribriform Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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