MCID: CRB006
MIFTS: 33

Cribriform Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Cribriform Carcinoma

MalaCards integrated aliases for Cribriform Carcinoma:

Name: Cribriform Carcinoma 12 15 17
Ductal Carcinoma, Cribriform Type 12
Carcinoma, Cribriform 71
Carcinoma Cribriform 54

Classifications:



External Ids:

Disease Ontology 12 DOID:5675
MeSH 43 D000230
NCIt 49 C3680
SNOMED-CT 67 30156004
UMLS 71 C0205643

Summaries for Cribriform Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by an irregular cribriform growth pattern, nuclear grade I in at least 90% of cells, and absent myoepithelial cells.

MalaCards based summary : Cribriform Carcinoma, also known as ductal carcinoma, cribriform type, is related to adenoid cystic carcinoma and benign breast phyllodes tumor. An important gene associated with Cribriform Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Signaling by ERBB4 and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include breast, prostate and lung, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Cribriform Carcinoma

Diseases related to Cribriform Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 334)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.7 TP63 PGR KRT8 KRT7 KRT5 KIT
2 benign breast phyllodes tumor 30.5 PGR KIT
3 tubular adenocarcinoma 30.4 PGR KRT7 ESR1 ERBB2
4 eyelid carcinoma 30.2 PIP KRT7
5 papillary carcinoma 30.1 PGR KRT7 ESR1 ERBB2
6 hypertrophy of breast 30.1 PGR GATA3 ESR1 ERBB2
7 adenoid basal cell carcinoma 30.0 KRT7 KIT ACCS
8 adenomatoid tumor 30.0 KRT7 KRT5
9 merkel cell carcinoma 29.9 KRT8 KRT7 KIT
10 breast disease 29.9 PGR KRT5 ESR1 ERBB2
11 basal cell carcinoma 29.3 TP63 KRT8 KRT7 KRT5 KIT
12 apocrine adenocarcinoma 28.7 PIP PGR KRT7 KRT5 GATA3 ESR1
13 breast cancer 28.1 TP63 PIP PGR KRT8 KRT7 KRT5
14 sweat gland cancer 28.1 PIP PGR KRT8 KRT7 KRT5 GATA3
15 cervical serous adenocarcinoma 10.5 PGR GATA3
16 chronic tympanitis 10.5 PGR ESR1
17 bartholin's gland adenoma 10.5 PGR ESR1
18 granulomatous endometritis 10.5 PGR ESR1
19 bartholin's gland benign neoplasm 10.5 PGR ESR1
20 vestibular gland benign neoplasm 10.5 PGR ESR1
21 uterine corpus adenosarcoma 10.5 PGR ESR1
22 vaginal glandular tumor 10.5 PGR ESR1
23 lung leiomyoma 10.5 PGR ESR1
24 trigonitis 10.5 PGR ESR1
25 cervical clear cell adenocarcinoma 10.5 PGR ESR1
26 adult cystic nephroma 10.5 PGR KIT
27 adult type testicular granulosa cell tumor 10.5 PGR ESR1
28 scirrhous adenocarcinoma 10.5 PGR ERBB2
29 thyroid carcinoma 10.5
30 intravenous leiomyomatosis 10.4 PGR ESR1
31 mammographic density 10.4 PGR ESR1
32 bizarre leiomyoma 10.4 PGR ESR1
33 apocrine adenosis of breast 10.4 PGR ERBB2
34 syringoma 10.4 KRT7 ESR1
35 vulvar leiomyoma 10.4 PGR ESR1
36 urethral villous adenoma 10.4 PGR KRT7
37 pregnancy adenoma 10.4 PGR KRT5
38 basaloid lung carcinoma 10.4 PGR KRT5
39 thyroid cancer, nonmedullary, 1 10.4
40 urinary bladder small cell neuroendocrine carcinoma 10.4 KRT7 GATA3
41 ureter small cell carcinoma 10.4 KRT7 GATA3
42 anus basaloid carcinoma 10.4 KRT7 KIT
43 cervical adenoid cystic carcinoma 10.4 KRT7 KIT
44 liver fibroma 10.4 KRT5 KIT
45 laryngeal small cell carcinoma 10.4 KRT5 KIT
46 benign metastasizing leiomyoma 10.4 PGR KRT7
47 colon leiomyosarcoma 10.4 KRT5 KIT
48 mucinous adenofibroma 10.4 KRT7 ESR1
49 atrophic vulva 10.4 KRT7 ESR1
50 breast myoepithelial carcinoma 10.4 PGR KRT5

Graphical network of the top 20 diseases related to Cribriform Carcinoma:



Diseases related to Cribriform Carcinoma

Symptoms & Phenotypes for Cribriform Carcinoma

MGI Mouse Phenotypes related to Cribriform Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 ERBB2 ESR1 GATA3 KIT KRT8 PGR
2 digestive/alimentary MP:0005381 9.97 ERBB2 ESR1 GATA3 KIT KRT5 KRT8
3 embryo MP:0005380 9.87 ERBB2 ESR1 GATA3 KIT KRT8 PGR
4 integument MP:0010771 9.8 ERBB2 ESR1 GATA3 KIT KRT5 PGR
5 limbs/digits/tail MP:0005371 9.63 ERBB2 ESR1 KIT KRT5 PGR TP63
6 normal MP:0002873 9.5 CLCA4 ERBB2 ESR1 GATA3 KIT PGR
7 reproductive system MP:0005389 9.23 ERBB2 ESR1 GATA3 KIT KRT8 PGR

Drugs & Therapeutics for Cribriform Carcinoma

Search Clinical Trials , NIH Clinical Center for Cribriform Carcinoma

Genetic Tests for Cribriform Carcinoma

Anatomical Context for Cribriform Carcinoma

MalaCards organs/tissues related to Cribriform Carcinoma:

40
Breast, Prostate, Lung, Bone, Lymph Node, Colon, Pancreas

Publications for Cribriform Carcinoma

Articles related to Cribriform Carcinoma:

(show top 50) (show all 96)
# Title Authors PMID Year
1
Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases. 61 54
18769339 2008
2
Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers. 61 54
16810311 2006
3
The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma. 61
32459716 2020
4
Gleason grade patterns in nodal metastasis and corresponding prostatectomy specimens: impact on patient outcome. 61
31177561 2019
5
Adenoid Cystic Carcinoma With Sialolithiasis of the Left Submandibular Gland: A Case Report and Literature Review. 61
30482073 2019
6
Malignant Sweat Gland Tumors. 61
30497677 2019
7
Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate. 61
30333152 2019
8
Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set. 61
30160779 2019
9
Large cribriform growth pattern identifies ISUP grade 2 prostate cancer at high risk for recurrence and metastasis. 61
30349027 2019
10
Survival pattern of rare histological types of breast cancer in a Nigerian institution. 61
31934255 2019
11
Role of Magnetic Resonance Imaging Targeted Biopsy in Detection of Prostate Cancer Harboring Adverse Pathological Features of Intraductal Carcinoma and Invasive Cribriform Carcinoma. 61
29408568 2018
12
GATA3 staining in primary cutaneous apocrine cribriform carcinoma: Usefulness to differentiate it from breast cancer metastasis. 61
29431200 2018
13
Primary Cutaneous Cribriform Carcinoma Treated With Mohs Micrographic Surgery. 61
28872559 2018
14
Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. 61
29205457 2018
15
The Distribution and Outcomes of the 21-Gene Recurrence Score in T1-T2N0 Estrogen Receptor-Positive Breast Cancer With Different Histologic Subtypes. 61
30619463 2018
16
A solid variant of primary cutaneous cribriform carcinoma: a small, stable, long-term lesion. 61
28508756 2017
17
Evaluation and comparison of radiologic-pathologic findings in invasive cribriform carcinoma of the breast. 61
28618754 2017
18
Implementation of a Precision Pathology Program Focused on Oncology-Based Prognostic and Predictive Outcomes. 61
28000172 2017
19
An Updated Review of Cribriform Carcinomas with Emphasis on Histopathological Diagnosis and Prognostic Significance. 61
28382188 2017
20
Primary Cribriform Carcinoma of the Eyelid With Neuroendocrine Features: A Case Report. 61
28300861 2017
21
Invasive cribriform carcinoma of the breast: a clinicopathological analysis of 12 cases with review of literature. 61
31966881 2017
22
Evaluation of ERG and PTEN protein expression in cribriform architecture prostate carcinomas. 61
27913052 2017
23
Bilateral Synchronous Male Breast Cancer of Rare Histologic Type. Case Report. 61
30142263 2016
24
Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial. 61
26387144 2015
25
Clinicopathological Characteristics and Survival Outcomes of Invasive Cribriform Carcinoma of Breast: A SEER Population-Based Study. 61
26252312 2015
26
Invasive cribriform carcinoma of the breast: mammographic, sonographic, MRI, and 18 F-FDG PET-CT features. 61
24938660 2015
27
Primary cutaneous cribriform carcinoma: report of six cases with clinicopathologic data and immunohistochemical profile. 61
25732813 2015
28
Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. 61
25789036 2015
29
Colonic cribriform carcinoma, a morphologic pattern associated with low survival. 61
25015669 2015
30
The association of the cribriform pattern with outcome for prostatic adenocarcinomas. 61
25042388 2014
31
Significance of the cribriform pattern in prostatic adenocarcinomas. 61
24831265 2014
32
Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort. 61
24703897 2014
33
Inconclusive or erroneous fine-needle aspirates of breast with adequate and representative material: a cytologic/histologic study. 61
24167007 2014
34
Predictors of recurrence in breast cancer subtypes with negative lymph node in a Chinese population. 61
25031741 2014
35
[Clinicopathologic features of collagenous spherulosis of the breast]. 61
24447549 2013
36
[Diagnostic value of computed tomography-guided percutaneous lung biopsy for malignant lung tumors]. 61
24417920 2013
37
Cribriform carcinoma mimicking breast abscess - case report. Diagnostic and therapeutic management. 61
26674469 2013
38
Mixed gastric carcinoma with intestinal and cribriform patterns: a distinctive pathologic appearance associated with poor prognosis in advanced stages and a potential mimicker of metastatic breast carcinoma. 61
22744963 2013
39
Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. 61
23412348 2013
40
A pure invasive cribriform carcinoma of the breast with bone metastasis if untreated for thirteen years: a case report and literature review. 61
23167837 2012
41
Primary cutaneous cribriform carcinoma of the neck: a case report. 61
23316623 2012
42
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. 61
23110003 2012
43
Adjuvant therapies for special types of breast cancer. 61
22015285 2011
44
Epstein-Barr virus and breast cancer: lack of evidence for an association in Iranian women. 61
21207256 2011
45
[Prostate cancer with five different histological features: a case report and review of the literature]. 61
21961246 2011
46
Sonographic findings of invasive cribriform carcinoma of the breast. 61
21527619 2011
47
Cutaneous cribriform carcinoma: a short comment. 61
21315957 2011
48
Intracystic papillary carcinoma of the breast: An in situ or invasive tumor? Results of immunohistochemical analysis and clinical follow-up. 61
21084964 2011
49
Original and infiltrating patterns of prostatic carcinoma. 61
22966253 2010
50
Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm. 61
19751882 2009

Variations for Cribriform Carcinoma

Expression for Cribriform Carcinoma

Search GEO for disease gene expression data for Cribriform Carcinoma.

Pathways for Cribriform Carcinoma

GO Terms for Cribriform Carcinoma

Cellular components related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.8 KRT8 KRT7 KRT5

Biological processes related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.58 TP63 GATA3 ESR1
2 cornification GO:0070268 9.54 KRT8 KRT7 KRT5
3 male gonad development GO:0008584 9.5 KIT GATA3 ESR1
4 anatomical structure formation involved in morphogenesis GO:0048646 9.49 TP63 GATA3
5 uterus development GO:0060065 9.48 GATA3 ESR1
6 embryonic hemopoiesis GO:0035162 9.46 KIT GATA3
7 sympathetic nervous system development GO:0048485 9.43 TP63 GATA3
8 positive regulation of phospholipase C activity GO:0010863 9.26 KIT ESR1
9 positive regulation of protein kinase B signaling GO:0051897 9.26 KIT GATA3 ESR1 ERBB2
10 epithelial cell development GO:0002064 9.16 TP63 ESR1
11 mast cell differentiation GO:0060374 8.62 KIT GATA3

Molecular functions related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.26 TP63 PGR GATA3 ESR1
2 identical protein binding GO:0042802 9.17 TP63 PIP PGR GATA3 ESR1 ERBB2

Sources for Cribriform Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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