CCHF
MCID: CRM001
MIFTS: 53

Crimean-Congo Hemorrhagic Fever (CCHF)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

MalaCards integrated aliases for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 12 58 3 15
Hemorrhagic Fever, Crimean 43 71
Crimean Hemorrhagic Fever 12 58
Congo Hemorrhagic Fever 58 71
Cchf 58 3
Congo-Crimean Hemorrhagic Fever 12
Hemorrhagic Fever Crimean-Congo 54
Chf Congo Virus 12
Congo Fever 58

Characteristics:

Orphanet epidemiological data:

58
crimean-congo hemorrhagic fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Crimean-Congo Hemorrhagic Fever

CDC : 3 Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease. Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

MalaCards based summary : Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to disseminated intravascular coagulation and neutropenia, and has symptoms including vomiting, jaundice and back pain. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Vaccines and Iron-Dextran Complex have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and liver, and related phenotypes are fatigue and fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

Wikipedia : 74 Crimean-Congo hemorrhagic fever (CCHF) is a viral disease. Symptoms of CCHF may include fever, muscle... more...

Related Diseases for Crimean-Congo Hemorrhagic Fever

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 31.1 TNF PIK3C2A IL6 GPT F3
2 neutropenia 31.1 TNF IL6 IFNA1 GPT
3 pharyngitis 31.1 TNF IL6 GPT
4 pericardial effusion 31.1 PIK3C2A IL6 GPT F3
5 leptospirosis 31.0 TNF PIK3C2A IL6
6 exanthem 31.0 TNF PIK3C2A IL6 IFNA1 GPT F3
7 lassa fever 30.9 MBTPS1 IFNA1 DDX58
8 yellow fever 30.8 IL6 IFNB1 CXCL10
9 purpura 30.8 TNF IL6 F3
10 dengue disease 30.7 TNF PIK3C2A IFNB1 IFNA1
11 hepatic encephalopathy 30.7 TNF IL6 GPT
12 covid-19 30.7 IL6 GPT FURIN
13 listeriosis 30.7 TNF IL6 IFNB1
14 diarrhea 30.6 TNF IL6 IFNB1 IFNA1 GPT
15 q fever 30.5 TNF TLR10 IL6
16 toxic shock syndrome 30.5 TNF IL6 F3
17 gastroenteritis 30.5 TNF IL6 IFNA1
18 ebola hemorrhagic fever 30.5 IFNB1 IFNA1 FURIN F3
19 vaccinia 30.5 TNF IL6 IFNB1 IFNA1
20 leishmaniasis 30.4 TNF IL6 IFNB1 GPT
21 tick-borne encephalitis 30.3 TLR3 IFNB1 IFNA1 DDX58 CXCL10
22 stomatitis 30.3 TNF MX1 IL6 IFNB1 IFNA1 DDX58
23 hantavirus hemorrhagic fever with renal syndrome 30.2 TNF MX1 IL6 F3 DDX58 CXCL10
24 plague 30.1 TNF TLR3 IL6 DDX58
25 meningoencephalitis 30.1 TNF TLR3 IL6 CXCL10
26 myocarditis 29.9 TNF TLR3 PIK3C2A IL6 IFNA1
27 avian influenza 29.9 TNF IL6 IFNA1 FURIN DDX58 CXCL10
28 lyme disease 29.8 TNF TLR7 IL6 IFNB1 IFNA1
29 hepatitis e 29.8 TNF TLR3 IFNB1 GPT DDX58
30 bacterial infectious disease 29.6 TNF TLR3 MX1 IL6 IFNB1
31 viral hepatitis 29.5 TNF TLR3 MX1 IL6 IFNA1 GPT
32 viral pneumonia 29.4 TNF TLR3 IL6 IFNB1 DDX58 CXCL10
33 chikungunya 29.4 TNF TLR8 TLR7 IL6 FURIN DDX58
34 japanese encephalitis 29.2 TNF TLR7 TLR3 IFNB1 IFNA1 CXCL10
35 encephalitis 29.2 TNF TLR3 MX1 IL6 IFNB1 IFNA1
36 thrombocytopenia 29.1 TNF TLR7 PIK3C2A IL6 IFNB1 IFNA1
37 severe acute respiratory syndrome 28.8 TNF MX1 IL6 IFNB1 IFNA1 GPT
38 dengue hemorrhagic fever 27.4 TNF TLR8 TLR7 TLR3 MX1 IL6
39 malaria 27.4 TNF TLR7 TLR3 IL6 IFNB1 IFNA1
40 viral infectious disease 27.2 TNF TLR8 TLR7 TLR3 MX1 IL6
41 viral hemorrhagic fever 10.9
42 hemorrhagic disease 10.9
43 rift valley fever 10.7
44 coccidioidomycosis 10.7
45 headache 10.7
46 brucellosis 10.6
47 splenomegaly 10.6
48 cytokine deficiency 10.6
49 west nile virus 10.5
50 lung mixed small cell and squamous cell carcinoma 10.5 PIK3C2A IFNA1

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to Crimean-Congo Hemorrhagic Fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 skin rash 58 31 frequent (33%) Frequent (79-30%) HP:0000988
4 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
5 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
6 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
7 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
8 hepatic steatosis 58 31 frequent (33%) Frequent (79-30%) HP:0001397
9 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
10 uveitis 58 31 frequent (33%) Frequent (79-30%) HP:0000554
11 recurrent pharyngitis 58 31 frequent (33%) Frequent (79-30%) HP:0100776
12 petechiae 58 31 frequent (33%) Frequent (79-30%) HP:0000967
13 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
14 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
15 gingival bleeding 58 31 occasional (7.5%) Occasional (29-5%) HP:0000225
16 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
17 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
18 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
19 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
20 epistaxis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000421
21 leukopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001882
22 cardiorespiratory arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0006543
23 abnormal bleeding 58 Occasional (29-5%)

Symptoms:

12 (show all 13)
  • vomiting
  • jaundice
  • back pain
  • petechiae
  • headache
  • stomach pain
  • nosebleeds
  • joint pain
  • high fever
  • red eyes
  • flushed face
  • red throat
  • blood in the feces

GenomeRNAi Phenotypes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 IFNA1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.7 ANGPT2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.7 CXCL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.7 ANGPT2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.7 ANGPT2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.7 IFNA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.7 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.7 CXCL10 IFNA1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.7 ANGPT2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.7 IFNA1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-175 9.7 ANGPT2 IFNA1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-209 9.7 IFNA1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 CXCL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-58 9.7 ANGPT2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-59 9.7 ANGPT2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-61 9.7 IFNA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.7 CXCL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.7 IFNA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.7 ANGPT2 IFNA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.7 IFNA1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-94 9.7 CXCL10

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CXCL10 DDX58 F3 FURIN IFNB1 IL6
2 homeostasis/metabolism MP:0005376 9.77 ANGPT2 CXCL10 DDX58 F3 IFNB1 IL6
3 immune system MP:0005387 9.47 ANGPT2 CHIT1 CXCL10 DDX58 F3 FURIN

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3
2 Iron-Dextran Complex Phase 3
3 polysaccharide-K Phase 3
4
Formaldehyde Approved, Vet_approved Phase 1 50-00-0 712
5 Pharmaceutical Solutions Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of a Heterologous, Two-dose Preventive Ebola Vaccine for Effectiveness and Safety in the Democratic Republic of the Congo Recruiting NCT04152486 Phase 3
2 Open-label Phase 2 Study to Evaluate the Immunogenicity and Safety of a Prophylactic Vaccination of Health Care Providers by Administration of a Heterologous Vaccine Regimen Against Ebola in the Democratic Republic of the Congo Recruiting NCT04186000 Phase 2
3 Treatment of Viral Hemorrhagic Fever (Crimean-Congo Hemorrhagic Fever or Lassa Fever) With Intravenous Ribavirin in Department of Defense (DOD) Associated Medical Treatment Facilities: A Phase 2 Study Withdrawn NCT00992693 Phase 2 Ribavirin (Virazole) Injection
4 Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans, Prepared in Cell Culture and Inactivated With Formalin, and Administered Subcutaneously or Intramuscularly With Two Different Doses Completed NCT03020771 Phase 1
5 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
6 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever (Crimean-Congo Hemorrhagic Fever or Lassa Fever) Recruiting NCT02483260 Ribavirin
7 Clinical Evaluation of the FilmArray® Global Fever (GF) Panel Recruiting NCT02968355
8 Evaluation and Support to Ebola Virus Disease Cured Patients and Their Contacts in the Democratic Republic of the Congo Not yet recruiting NCT04409405

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

40
Eye, Skin, Liver, Testes, Endothelial, Heart, Brain

Publications for Crimean-Congo Hemorrhagic Fever

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 1056)
# Title Authors PMID Year
1
Antigen-capture enzyme-linked immunosorbent assay for the diagnosis of crimean-congo hemorrhagic fever using a novel monoclonal antibody. 61 54
16032715 2005
2
Recombinant nucleoprotein-based serological diagnosis of Crimean-Congo hemorrhagic fever virus infections. 61 54
15602720 2005
3
Identification and validation of internal reference genes for real-time quantitative polymerase chain reaction-based studies in Hyalomma anatolicum ticks. 61
32222359 2020
4
Detection of African genotype in Hyalomma tick pools during Crimean Congo hemorrhagic fever outbreak, Rajasthan, India, 2019. 61
32505728 2020
5
Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein. 61
32497085 2020
6
Seroepidemiological Investigation of Crimean-Congo Hemorrhagic Fever Virus in Sheep and Camels of Inner Mongolia of China. 61
32155395 2020
7
Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests. 61
32492018 2020
8
COVID-19 and Crimean-Congo Hemorrhagic Fever: Similarities and Differences. 61
32536567 2020
9
Mutagenic analysis of Hazara nairovirus non-translated regions during single and multi-step growth identifies both attenuating and functionally-critical sequences for virus replication. 61
32522854 2020
10
Evaluation and comparison of tick detachment techniques and technical mistakes made during tick removal. 61
32436976 2020
11
Serological Evidence of Yersiniosis, Tick-Borne Encephalitis, West Nile, Hepatitis E, Crimean-Congo Hemorrhagic Fever, Lyme Borreliosis, and Brucellosis in Febrile Patients Presenting at Diverse Hospitals in Kenya. 61
31928511 2020
12
Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. 61
32397953 2020
13
Beyond HIV infection: Neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases. 61
32479976 2020
14
Crimean-Congo Hemorrhagic Fever Virus Antibodies among Livestock on Corsica, France, 2014-2016. 61
32310061 2020
15
Crimean-Congo Hemorrhagic Fever Virus Endemicity in United Arab Emirates, 2019. 61
32097111 2020
16
Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesticated Animals in Northwestern Senegal. 61
32429789 2020
17
Identification of functional epitopes of structural proteins and in-silico designing of dual acting multiepitope anti-tick vaccine against emerging Crimean-Congo hemorrhagic fever virus. 61
32479862 2020
18
Efficient production of a lentiviral system for displaying Crimean-Congo hemorrhagic fever virus glycoproteins reveals a broad range of cellular susceptibility and neutralization ability. 61
32189084 2020
19
Molecular discrimination of Hyalomma tick species serving as reservoirs and vectors for Crimean-Congo hemorrhagic fever virus in sub-Saharan Africa. 61
32008996 2020
20
Investigation of Crimean-Congo hemorrhagic fever virus in ruminant species slaughtered in several endemic provinces in Turkey. 61
32435856 2020
21
The Crimean-Congo Hemorrhagic Fever Virus NSm Protein is Dispensable for Growth In Vitro and Disease in Ifnar-/- Mice. 61
32455700 2020
22
Dual RNA-Seq characterization of host and pathogen gene expression in liver cells infected with Crimean-Congo Hemorrhagic Fever Virus. 61
32251473 2020
23
New aspects about Crimean-Congo hemorrhagic fever (CCHF) cases and associated fatality trends: A global systematic review and meta-analysis. 61
32062190 2020
24
Crimean-Congo hemorrhagic fever virus in tortoises and Hyalomma aegyptium ticks in East Thrace, Turkey: potential of a cryptic transmission cycle. 61
32307010 2020
25
Prevalence of Antibodies to Crimean-Congo Hemorrhagic Fever Virus in Ruminants, Nigeria, 2015. 61
32186489 2020
26
Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015-2017. 61
32187506 2020
27
Crimean-Congo hemorrhagic fever virus infection triggers the upregulation of the Wnt signaling pathway inhibitor genes. 61
32335793 2020
28
Systematic Review of Important Viral Diseases in Africa in Light of the 'One Health' Concept. 61
32325980 2020
29
Application of Viral Metagenomics for Study of Emerging and Reemerging Tick-Borne Viruses. 61
32267808 2020
30
Crimean-Congo Hemorrhagic Fever, Mauritania. 61
32187505 2020
31
Glutamine depletion in patients with Crimean-Congo Hemorrhagic Fever. 61
32281664 2020
32
Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38. 61
31996434 2020
33
Diagnostic Testing for Crimean-Congo Hemorrhagic Fever. 61
32024724 2020
34
Mapping the environmental suitability of etiological agent and tick vectors of Crimean-Congo hemorrhagic fever. 61
31874130 2020
35
Association of MCP-1 promotor polymorphism with disease severity of Crimean-Congo hemorrhagic fever. 61
32219866 2020
36
Seroprevalence of Crimean-Congo hemorrhagic fever in humans in the World Health Organization European region: A systematic review. 61
32119682 2020
37
In Silico Modeling of Crimean Congo Hemorrhagic Fever Virus Glycoprotein-N and Screening of Anti Viral Hits by Virtual Screening. 61
32421093 2020
38
Modeling tick vaccines: a key tool to improve protection efficacy. 61
32192377 2020
39
Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol. 61
31931103 2020
40
Sero-Epidemiological Survey of Crimean-Congo Hemorrhagic Fever among the Human Population of the Punjab Province in Pakistan. 61
32103447 2020
41
An Evaluation of the Different Serum Markers Associated with Mortality in Crimean-Congo Hemorrhagic Fever. 61
32077849 2020
42
[Erratum to "Crimean-Congo hemorrhagic fever: An update". [Med. Mal. Infect. 49 (2019) 574-585]]. 61
31924456 2020
43
Persistence of Crimean-Congo Hemorrhagic Fever Virus RNA. 61
31961316 2020
44
Atypical Presentation of Crimean-Congo Hemorrhagic Fever as Ascending Paralysis with Rhabdomyolysis. 61
32205950 2020
45
Ixodid tick species and two tick-borne pathogens in three areas in the Sudan. 61
31901105 2020
46
The use of mice lacking type I or both type I and type II interferon responses in research on hemorrhagic fever viruses. Part 2: Vaccine efficacy studies. 61
31982149 2020
47
Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. 61
31486732 2020
48
Crimean-Congo Hemorrhagic Fever Virus: Advances in Vaccine Development. 61
32461819 2020
49
Risk Factors for and Seroprevalence of Tickborne Zoonotic Diseases among Livestock Owners, Kazakhstan. 61
31855140 2020
50
Crimean-Congo hemorrhagic fever virus replication imposes hyper-lipidation of MAP1LC3 in epithelial cells. 61
31905032 2020

Variations for Crimean-Congo Hemorrhagic Fever

Expression for Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for Crimean-Congo Hemorrhagic Fever

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR8 TLR7 TLR3 TLR10 MX1
2
Show member pathways
13.35 TNF TLR8 TLR7 TLR3 TLR10 IL6
3
Show member pathways
13.3 TNF MX1 IL6 IFNB1 IFNA1 DDX58
4
Show member pathways
12.9 TNF TLR3 MX1 IL6 IFNB1 IFNA1
5
Show member pathways
12.89 TNF TLR3 IL6 IFNB1 IFNA1 ANGPT2
6
Show member pathways
12.74 TNF TLR8 TLR7 TLR3 MX1 IL6
7 12.73 TNF TLR3 IL6 IFNB1 IFNA1 DDX58
8
Show member pathways
12.63 TNF TLR8 TLR7 TLR3 TLR10 IL6
9
Show member pathways
12.53 TNF TLR8 TLR7 TLR3 TLR10
10
Show member pathways
12.49 TNF IFNB1 IFNA1 DDX58 CXCL10
11 12.49 TNF TLR8 TLR7 TLR3 IFNA1 DDX58
12
Show member pathways
12.48 TLR3 IL6 IFNB1 IFNA1 DDX58 CXCL10
13
Show member pathways
12.32 TNF TLR7 TLR3 MX1 IL6 IFNB1
14
Show member pathways
12.22 TNF MX1 IL6 IFNB1 IFNA1
15 12.2 TNF IL6 IFNB1 IFNA1
16 12.19 TNF IL6 IFNB1 IFNA1
17
Show member pathways
12.16 TNF TLR3 IFNB1 IFNA1
18 12.1 TNF TLR8 TLR7 TLR3 TLR10 IL6
19
Show member pathways
12.08 TNF TLR8 TLR7 TLR3 TLR10 IL6
20
Show member pathways
12.06 TNF TLR8 TLR7 IL6 IFNB1 CXCL10
21
Show member pathways
11.97 TLR8 TLR7 TLR3 TLR10 PIK3C2A
22 11.92 TNF IL6 IFNB1 CXCL10
23
Show member pathways
11.91 TNF TLR8 TLR7 TLR3 TLR10 IL6
24
Show member pathways
11.82 TNF TLR8 TLR7 TLR3 TLR10 IL6
25
Show member pathways
11.81 TLR8 TLR7 TLR3 TLR10 IL6
26 11.79 IL6 IFNB1 IFNA1
27 11.78 TLR8 TLR7 TLR3 TLR10
28 11.68 TNF TLR7 IL6 IFNB1
29 11.49 TNF IL6 CXCL10
30 11.47 IL6 IFNB1 IFNA1
31 11.21 TNF IL6 IFNB1

GO Terms for Crimean-Congo Hemorrhagic Fever

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 TNF SCUBE1 IL6 IFNB1 IFNA1 FURIN
2 endosome membrane GO:0010008 9.56 TLR8 TLR7 TLR3 FURIN
3 extracellular space GO:0005615 9.4 TNF TLR3 SCUBE1 IL6 IFNB1 IFNA1
4 endolysosome membrane GO:0036020 9.13 TLR8 TLR7 TLR3

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 TLR8 TLR7 TLR3 TLR10 SCUBE1 MX1
2 immune system process GO:0002376 10.12 TLR8 TLR7 TLR3 TLR10 MX1 DDX58
3 innate immune response GO:0045087 10.09 TLR8 TLR7 TLR3 TLR10 MX1 DDX58
4 immune response GO:0006955 10.07 TNF TLR8 TLR7 TLR10 IL6 CXCL10
5 positive regulation of gene expression GO:0010628 10.06 TNF TLR3 IL6 F3 DDX58
6 cytokine-mediated signaling pathway GO:0019221 10.01 TNF IL6 IFNB1 IFNA1 F3 CXCL10
7 blood coagulation GO:0007596 9.93 SCUBE1 IFNB1 IFNA1 F3
8 positive regulation of inflammatory response GO:0050729 9.9 TNF TLR7 TLR3 TLR10
9 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.87 TNF TLR8 TLR7 TLR3
10 inflammatory response GO:0006954 9.86 TNF TLR8 TLR7 TLR3 TLR10 SCUBE1
11 humoral immune response GO:0006959 9.85 TNF IL6 IFNB1 IFNA1
12 cellular response to mechanical stimulus GO:0071260 9.84 TLR8 TLR7 TLR3
13 type I interferon signaling pathway GO:0060337 9.83 MX1 IFNB1 IFNA1
14 regulation of protein phosphorylation GO:0001932 9.82 TNF TLR8 TLR7
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TNF TLR7 TLR3
16 toll-like receptor signaling pathway GO:0002224 9.81 TLR8 TLR7 TLR3 TLR10
17 positive regulation of interleukin-6 secretion GO:2000778 9.8 TNF TLR8 DDX58
18 defense response GO:0006952 9.8 TNF TLR3 MX1 IFNB1 IFNA1 CXCL10
19 negative regulation of viral genome replication GO:0045071 9.79 TNF MX1 IFNB1
20 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.78 TLR8 TLR7 TLR10
21 response to exogenous dsRNA GO:0043330 9.78 TLR3 IFNB1 IFNA1 DDX58
22 cellular response to exogenous dsRNA GO:0071360 9.76 TLR3 IFNB1 DDX58
23 microglial cell activation GO:0001774 9.76 TNF TLR8 TLR7 TLR3
24 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.75 TNF TLR8 TLR7
25 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.73 TLR8 TLR7 TLR3
26 positive regulation of interleukin-8 production GO:0032757 9.73 TNF TLR7 TLR3 DDX58
27 positive regulation of chemokine biosynthetic process GO:0045080 9.68 TNF TLR3
28 positive regulation of neuroinflammatory response GO:0150078 9.68 TNF IL6
29 regulation of cytokine secretion GO:0050707 9.67 TLR8 TLR10
30 I-kappaB phosphorylation GO:0007252 9.67 TLR7 TLR3
31 positive regulation of interferon-beta biosynthetic process GO:0045359 9.67 TLR8 TLR7 TLR3
32 positive regulation of chemokine production GO:0032722 9.67 TNF TLR7 TLR3 IL6
33 negative regulation of lipid storage GO:0010888 9.66 TNF IL6
34 necroptotic signaling pathway GO:0097527 9.65 TNF TLR3
35 detection of virus GO:0009597 9.63 TLR3 DDX58
36 positive regulation of interleukin-6 production GO:0032755 9.63 TNF TLR8 TLR7 TLR3 IL6 DDX58
37 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.58 TLR8 TLR7 TLR3
38 response to virus GO:0009615 9.5 TNF TLR8 TLR3 MX1 IFNB1 DDX58
39 defense response to virus GO:0051607 9.28 TLR8 TLR7 TLR3 MX1 IL6 IFNB1

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF IL6 IFNB1 IFNA1 CXCL10
2 single-stranded RNA binding GO:0003727 9.33 TLR8 TLR7 DDX58
3 pattern recognition receptor activity GO:0038187 9.26 TLR8 TLR7
4 double-stranded RNA binding GO:0003725 8.92 TLR8 TLR7 TLR3 DDX58

Sources for Crimean-Congo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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