CCHF
MCID: CRM001
MIFTS: 49

Crimean-Congo Hemorrhagic Fever (CCHF)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

MalaCards integrated aliases for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 12 59 3 15
Hemorrhagic Fever, Crimean 44 72
Crimean Hemorrhagic Fever 12 59
Congo Hemorrhagic Fever 59 72
Cchf 59 3
Congo-Crimean Hemorrhagic Fever 12
Hemorrhagic Fever Crimean-Congo 55
Chf Congo Virus 12
Congo Fever 59

Characteristics:

Orphanet epidemiological data:

59
crimean-congo hemorrhagic fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12287
ICD9CM 35 065.0
MeSH 44 D006479
NCIt 50 C34682
SNOMED-CT 68 43489008
ICD10 33 A98.0
ICD10 via Orphanet 34 A98.0
UMLS via Orphanet 73 C0019099
Orphanet 59 ORPHA99827
UMLS 72 C0019099 C1304456

Summaries for Crimean-Congo Hemorrhagic Fever

CDC : 3 Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease. Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

MalaCards based summary : Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to japanese encephalitis and spotted fever, and has symptoms including vomiting, jaundice and back pain. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drugs Ribavirin and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and liver, and related phenotypes are fever and fatigue

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

Wikipedia : 75 Crimean-Congo hemorrhagic fever (CCHF) is a viral disease. Symptoms of CCHF may include fever, muscle... more...

Related Diseases for Crimean-Congo Hemorrhagic Fever

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 japanese encephalitis 31.1 TNF CXCL10
2 spotted fever 31.0 TNF CXCL10
3 listeriosis 30.9 TNF IL6
4 leptospirosis 30.8 TNF PIK3C2A IL6
5 exanthem 30.7 TNF IL6
6 aphthous stomatitis 30.7 TNF IL6
7 dengue hemorrhagic fever 30.6 TNF IL6 F3
8 purpura 30.6 TNF IL6 F3
9 q fever 30.6 TNF IL6
10 hepatic encephalopathy 30.6 TNF IL6 GPT
11 bacterial infectious disease 30.5 TREM1 TNF IL6
12 toxic shock syndrome 30.5 TREM1 TNF IL6
13 viral infectious disease 30.1 TNF IL6 GPT CXCL10
14 malaria 29.4 TNF IL6 F3 CXCL10 CHIT1
15 viral hemorrhagic fever 10.9
16 hemorrhagic disease 10.9
17 thrombocytopenia 10.8
18 disseminated intravascular coagulation 10.7
19 rift valley fever 10.7
20 coccidioidomycosis 10.7
21 neutropenia 10.7
22 headache 10.7
23 splenomegaly 10.6
24 brucellosis 10.6
25 stomatitis 10.6
26 cytokine deficiency 10.6
27 shwartzman phenomenon 10.6 TNF F3
28 adult dermatomyositis 10.5 TNF GPT
29 west nile virus 10.5
30 tick-borne encephalitis 10.5
31 opisthorchiasis 10.5 TNF GPT
32 analbuminemia 10.5 GPT F3
33 erysipelas 10.5 TNF PIK3C2A
34 chikungunya 10.5
35 hemophagocytic lymphohistiocytosis 10.5
36 korean hemorrhagic fever 10.5
37 hemorrhagic fever with renal syndrome 10.5
38 hemopericardium 10.5
39 pericardial effusion 10.5
40 diarrhea 10.5
41 encephalitis 10.5
42 compartment syndrome 10.5 TNF PIK3C2A
43 vibrio vulnificus infection 10.5 PIK3C2A IL6
44 pyoderma 10.5 TNF F3
45 scorpion envenomation 10.4 TNF IL6
46 transient arthritis 10.4 IL6 F3
47 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
48 autoimmune myocarditis 10.4 TNF IL6
49 streptococcal toxic-shock syndrome 10.4 TNF IL6
50 juvenile ankylosing spondylitis 10.4 TNF IL6

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to Crimean-Congo Hemorrhagic Fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

59 32 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
3 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
4 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
5 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
6 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
7 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
8 hepatic steatosis 59 32 frequent (33%) Frequent (79-30%) HP:0001397
9 elevated hepatic transaminase 59 32 frequent (33%) Frequent (79-30%) HP:0002910
10 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
11 uveitis 59 32 frequent (33%) Frequent (79-30%) HP:0000554
12 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
13 recurrent pharyngitis 59 32 frequent (33%) Frequent (79-30%) HP:0100776
14 petechiae 59 32 frequent (33%) Frequent (79-30%) HP:0000967
15 gingival bleeding 59 32 occasional (7.5%) Occasional (29-5%) HP:0000225
16 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
17 chest pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0100749
18 thrombocytopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001873
19 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952
20 epistaxis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000421
21 leukopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001882
22 cardiorespiratory arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0006543
23 abnormal bleeding 59 Occasional (29-5%)

Symptoms:

12 (show all 13)
  • vomiting
  • jaundice
  • back pain
  • headache
  • petechiae
  • stomach pain
  • nosebleeds
  • joint pain
  • high fever
  • red eyes
  • flushed face
  • red throat
  • blood in the feces

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CHIT1 CXCL10 F3 IL6 PIK3C2A TNF

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2 Antimetabolites Phase 2
3 Antiviral Agents Phase 2
4 Anti-Infective Agents Phase 2
5
Formaldehyde Approved, Vet_approved Phase 1 50-00-0 712
6 Pharmaceutical Solutions Phase 1
7 Immunologic Factors Phase 1
8 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fever (Crimean-Congo Hemorrhagic Fever or Lassa Fever) With Intravenous Ribavirin in Department of Defense (DOD) Associated Medical Treatment Facilities: A Phase 2 Study Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans, Prepared in Cell Culture and Inactivated With Formalin, and Administered Subcutaneously or Intramuscularly With Two Different Doses Completed NCT03020771 Phase 1
3 Causes of Acute Undifferentiated Fever in Outpatients in the Democratic Republic of Congo Completed NCT02656862
4 Clinical Evaluation of the FilmArray® Global Fever (GF) Panel Recruiting NCT02968355
5 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever (Crimean-Congo Hemorrhagic Fever or Lassa Fever) Enrolling by invitation NCT02483260 Ribavirin

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

41
Skin, Eye, Liver, Testes, Endothelial, Heart, Brain

Publications for Crimean-Congo Hemorrhagic Fever

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 986)
# Title Authors PMID Year
1
Antigen-capture enzyme-linked immunosorbent assay for the diagnosis of crimean-congo hemorrhagic fever using a novel monoclonal antibody. 9 38
16032715 2005
2
Recombinant nucleoprotein-based serological diagnosis of Crimean-Congo hemorrhagic fever virus infections. 9 38
15602720 2005
3
Identification of potential microRNA markers related to Crimean-Congo hemorrhagic fever disease. 38
31044455 2019
4
An evaluation of the different biomarkers to discriminate bleeding in Crimean-Congo Hemorrhagic Fever. 38
31151923 2019
5
Hitit Index to distinguish patients with and without Crimean-Congo hemorrhagic fever. 38
31160263 2019
6
Crimean-Congo hemorrhagic fever (CCHF) seroprevalence: A systematic review and meta-analysis. 38
31108083 2019
7
Apoptosis and its relation with clinical course in patients with Crimean-Congo hemorrhagic fever. 38
30905066 2019
8
Crimean-Congo Hemorrhagic Fever, Herat Province, Afghanistan, 2017. 38
31216260 2019
9
Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine. 38
31377243 2019
10
The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever 38
31293143 2019
11
Rescue of Infectious Recombinant Hazara Nairovirus from cDNA Reveals the Nucleocapsid Protein DQVD Caspase Cleavage Motif Performs an Essential Role other than Cleavage. 38
31118258 2019
12
Characterization of Novel Reoviruses Wad Medani Virus (Orbivirus) and Kundal Virus (Coltivirus) Collected from Hyalomma anatolicum Ticks in India during Surveillance for Crimean Congo Hemorrhagic Fever. 38
30971476 2019
13
A Crimean-Congo Hemorrhagic Fever Mouse Model Recapitulating Human Convalescence. 38
31292241 2019
14
Multivariate relationships between epidemiologic risk factors and zoonotic infections among military personnel in the country of Georgia: A non-linear canonical correlation analysis. 38
31338987 2019
15
Characterization of Biomarker Levels in Crimean-Congo Hemorrhagic Fever and Hantavirus Fever with Renal Syndrome. 38
31357521 2019
16
Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection. 38
31337717 2019
17
GP38-targeting monoclonal antibodies protect adult mice against lethal Crimean-Congo hemorrhagic fever virus infection. 38
31309159 2019
18
Crimean-Congo Hemorrhagic Fever Virus Genome in Tick from Migratory Bird, Italy. 38
31211933 2019
19
Persistence of IgG antibodies in survivors of Crimean Congo hemorrhagic fever virus infection, India. 38
31027886 2019
20
Elevated Human Crimean-Congo Hemorrhagic Fever Virus Seroprevalence in Khashm el Girba, Eastern Sudan. 38
30994100 2019
21
Scoping Review of Crimean-Congo Hemorrhagic Fever (CCHF) Literature and Implications of Future Research. 38
31133158 2019
22
Survey of Crimean-Congo Hemorrhagic Fever Enzootic Focus, Spain, 2011-2015. 38
31107219 2019
23
The Ecology of New Constituents of the Tick Virome and Their Relevance to Public Health. 38
31181599 2019
24
A Review of Zoonotic Pathogens of Dromedary Camels. 38
31140075 2019
25
Emerging arboviruses of medical importance in the Mediterranean region. 38
30928817 2019
26
Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease. 38
31261754 2019
27
Diagnostic approaches for Crimean-Congo hemorrhagic fever virus. 38
31053042 2019
28
Regulation of Hazara virus growth through apoptosis inhibition by viral nucleoprotein. 38
30949813 2019
29
Towards the first multi-epitope recombinant vaccine against Crimean-Congo hemorrhagic fever virus: A computer-aided vaccine design approach. 38
30928513 2019
30
In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors. 38
31048746 2019
31
Lassa and Crimean-Congo Hemorrhagic Fever Viruses, Mali. 38
31002054 2019
32
Evaluation of Crimean-Congo Hemorrhagic Fever Orthonairovirus AviTagged Nucleoprotein for Potential Application in Diagnosis 38
31104398 2019
33
Next-generation Sequencing Study of Pathogens in Serum from Patients with Febrile Jaundice in Sierra Leone. 38
31217053 2019
34
Risk factors associated with sustained circulation of six zoonotic arboviruses: a systematic review for selection of surveillance sites in non-endemic areas. 38
31133059 2019
35
Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever. 38
31123310 2019
36
Evaluation of Portal Vein Doppler Findings in Patients with Crimean⁻Congo Hemorrhagic Fever. 38
31100950 2019
37
Clinical and molecular epidemiology of Crimean-Congo hemorrhagic fever in Oman. 38
31022170 2019
38
Current Status of Tick-Borne Diseases in South Korea. 38
30328790 2019
39
Emerging zoonotic viral infections of occupational health importance. 38
30916772 2019
40
Evaluation of Crimean-Congo hemorrhagic fever suspected cases admitted to a secondary care hospital in Kastamonu, Turkey between 2014-2017. 38
31148970 2019
41
Genotypic analysis of S segment of Crimean-Congo hemorrhagic fever virus in Turkey. 38
30203691 2019
42
Crimean Congo Hemorrhagic Fever in Eastern Turkey: Epidemiological and Clinical Evaluation 38
30938129 2019
43
Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever. 38
30465883 2019
44
The pulmonary findings of Crimean-Congo hemorrhagic fever patients with chest X-ray assessments. 38
30911987 2019
45
Immunoglobulin-like Domain of HsFcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies. 38
30709812 2019
46
Crimean-Congo hemorrhagic fever virus nucleocapsid protein harbors distinct RNA-binding sites in the stalk and head domains. 38
30723154 2019
47
Evaluation of first rapid diagnostic kit for Anti-Crimean-Congo Hemorrhagic Fever virus IgM antibody using clinical samples from Iran. 38
30579923 2019
48
Evidence of Crimean-Congo Haemorrhagic Fever Virus Occurrence in Ixodidae Ticks of Armenia. 38
31346531 2019
49
Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR-/- Mice Models. 38
30857305 2019
50
A Minigenome Study of Hazara Nairovirus Genomic Promoters. 38
30626667 2019

Variations for Crimean-Congo Hemorrhagic Fever

Expression for Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for Crimean-Congo Hemorrhagic Fever

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 TREM1 TNF IL6 IFNA17 CXCL10
2
Show member pathways
12.37 TNF IL6 IFNA17 CXCL10
3
Show member pathways
12.07 TNF IL6 CXCL10
4 11.94 TNF IL6 IFNA17
5
Show member pathways
11.92 TNF IL6 F3
6
Show member pathways
11.85 TNF IL6 CXCL10
7 11.62 TNF IL6 CXCL10
8 11.55 TNF IL6 CXCL10
9 11.43 TNF IL6 F3
10 11.14 TNF IL6
11 11.13 TNF IL6
12 11.07 TNF IL6
13 11.04 TNF IL6
14 11 TNF IL6
15 10.98 TNF IL6 CXCL10
16 10.93 TNF IL6 CXCL10
17 10.82 TNF IL6
18 10.71 TNF IL6
19 10.49 TNF IL6 CXCL10

GO Terms for Crimean-Congo Hemorrhagic Fever

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TREM1 TNF PON1 IL6 IFNA17 F3
2 extracellular space GO:0005615 9.23 TNF PON1 IL6 IFNA17 GPT F3

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 TNF IL6 CXCL10 CHIT1
2 defense response to virus GO:0051607 9.7 IL6 IFNA17 CXCL10
3 cellular response to lipopolysaccharide GO:0071222 9.65 TNF IL6 CXCL10
4 defense response GO:0006952 9.58 TNF IFNA17 CXCL10
5 negative regulation of neurogenesis GO:0050768 9.51 TNF IL6
6 response to virus GO:0009615 9.5 TNF IFNA17 CXCL10
7 negative regulation of myoblast differentiation GO:0045662 9.49 TNF CXCL10
8 positive regulation of chemokine production GO:0032722 9.43 TNF IL6
9 positive regulation of glial cell proliferation GO:0060252 9.37 TNF IL6
10 cytokine-mediated signaling pathway GO:0019221 9.35 TNF IL6 IFNA17 F3 CXCL10
11 negative regulation of lipid storage GO:0010888 9.26 TNF IL6
12 positive regulation of neuroinflammatory response GO:0150078 9.16 TNF IL6
13 humoral immune response GO:0006959 8.92 TREM1 TNF IL6 IFNA17

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL6 IFNA17 CXCL10

Sources for Crimean-Congo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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