MCID: CRM001
MIFTS: 55

Crimean-Congo Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

MalaCards integrated aliases for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 12 60 3 15
Hemorrhagic Fever, Crimean 45 74
Crimean Hemorrhagic Fever 12 60
Congo Hemorrhagic Fever 60 74
Cchf 60 3
Congo-Crimean Hemorrhagic Fever 12
Hemorrhagic Fever Crimean-Congo 56
Chf Congo Virus 12
Congo Fever 60

Characteristics:

Orphanet epidemiological data:

60
crimean-congo hemorrhagic fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Crimean-Congo Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary : Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to purpura and leptospirosis, and has symptoms including vomiting, jaundice and back pain. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drugs Ribavirin and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and liver, and related phenotypes are fever and fatigue

CDC : 3 Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

Wikipedia : 77 Crimean–Congo hemorrhagic fever (CCHF) is a viral disease. Symptoms of CCHF may include fever, muscle... more...

Related Diseases for Crimean-Congo Hemorrhagic Fever

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 purpura 30.4 F3 IL6 TNF
2 leptospirosis 30.4 IL6 PIK3C2A TNF
3 malaria 29.5 CHIT1 CXCL10 F3 IL6 TNF
4 rift valley fever 10.6
5 coccidioidomycosis 10.6
6 west nile virus 10.4
7 tick-borne encephalitis 10.4
8 brucellosis 10.4
9 encephalitis 10.4
10 stomatitis 10.4
11 analbuminemia 10.3 F3 GPT
12 shwartzman phenomenon 10.3 F3 TNF
13 vascular hemostatic disease 10.3 F3 TNF
14 adult dermatomyositis 10.3 GPT TNF
15 opisthorchiasis 10.3 GPT TNF
16 nonalcoholic steatohepatitis 10.3 GPT TNF
17 erysipelas 10.3 PIK3C2A TNF
18 compartment syndrome 10.3 PIK3C2A TNF
19 pyoderma 10.3 F3 TNF
20 vibrio vulnificus infection 10.3 IL6 PIK3C2A
21 blood group, colton system 10.3
22 blood group--ul system 10.3
23 spondylocarpotarsal synostosis syndrome 10.3
24 resting heart rate, variation in 10.3
25 dengue virus 10.3
26 pulmonary hypertension 10.3
27 arthritis 10.3
28 hemophagocytic lymphohistiocytosis 10.3
29 thrombocytopenia 10.3
30 chikungunya 10.3
31 korean hemorrhagic fever 10.3
32 parotitis 10.3
33 thrombotic thrombocytopenic purpura 10.3
34 hemorrhagic fever with renal syndrome 10.3
35 cholecystitis 10.3
36 post-traumatic stress disorder 10.3
37 bilirubin metabolic disorder 10.3
38 acalculous cholecystitis 10.3
39 acute pancreatitis 10.3
40 ischemia 10.3
41 pancreatitis 10.3
42 myocarditis 10.3
43 appendicitis 10.3
44 leishmaniasis 10.3
45 visceral leishmaniasis 10.3
46 yellow fever 10.3
47 cytokine deficiency 10.3
48 syndrome of inappropriate antidiuretic hormone 10.3
49 headache 10.3
50 vitamin b12 deficiency 10.2 GPT PON1

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to Crimean-Congo Hemorrhagic Fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

60 33 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
3 nausea and vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002017
4 abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002027
5 hepatic steatosis 60 33 frequent (33%) Frequent (79-30%) HP:0001397
6 elevated hepatic transaminase 60 33 frequent (33%) Frequent (79-30%) HP:0002910
7 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
8 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
9 diarrhea 60 33 frequent (33%) Frequent (79-30%) HP:0002014
10 recurrent pharyngitis 60 33 frequent (33%) Frequent (79-30%) HP:0100776
11 skin rash 60 33 frequent (33%) Frequent (79-30%) HP:0000988
12 cough 60 33 frequent (33%) Frequent (79-30%) HP:0012735
13 petechiae 60 33 frequent (33%) Frequent (79-30%) HP:0000967
14 uveitis 60 33 frequent (33%) Frequent (79-30%) HP:0000554
15 thrombocytopenia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001873
16 jaundice 60 33 occasional (7.5%) Occasional (29-5%) HP:0000952
17 gastrointestinal hemorrhage 60 33 occasional (7.5%) Occasional (29-5%) HP:0002239
18 chest pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0100749
19 epistaxis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000421
20 gingival bleeding 60 33 occasional (7.5%) Occasional (29-5%) HP:0000225
21 leukopenia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001882
22 cardiorespiratory arrest 60 33 occasional (7.5%) Occasional (29-5%) HP:0006543
23 abnormal bleeding 60 Occasional (29-5%)

Symptoms:

12 (show all 13)
  • vomiting
  • jaundice
  • back pain
  • headache
  • joint pain
  • nosebleeds
  • high fever
  • stomach pain
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • blood in the feces

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CHIT1 CXCL10 F3 IL6 PIK3C2A TNF

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2,Not Applicable 36791-04-5 37542
2 Antiviral Agents Phase 2,Not Applicable
3 Anti-Infective Agents Phase 2,Not Applicable
4 Antimetabolites Phase 2,Not Applicable
5
Formaldehyde Approved, Vet_approved Phase 1 50-00-0 712
6 Immunologic Factors Phase 1
7 Pharmaceutical Solutions Phase 1
8 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans Completed NCT03020771 Phase 1
3 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
4 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260 Not Applicable Ribavirin

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

42
Skin, Eye, Liver, Heart, Testes, Endothelial, Brain

Publications for Crimean-Congo Hemorrhagic Fever

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 713)
# Title Authors Year
1
Effects of Paraoxonase-1 variants on course of severity and mortality of Crimean-Congo hemorrhagic fever. ( 30465883 )
2019
2
Factors related to fatalities and clinical progression of Crimean-Congo hemorrhagic fever patients and the effects of IL 28-B gene polymorphism. ( 30478788 )
2019
3
An Emerging Biothreat: Crimean-Congo Hemorrhagic Fever Virus in Southern and Western Asia. ( 30652673 )
2019
4
Co-Delivery Effect of CD24 on the Immunogenicity and Lethal Challenge Protection of a DNA Vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus. ( 30658445 )
2019
5
Crimean-Congo hemorrhagic fever and expansion from endemic regions. ( 30660091 )
2019
6
Crimean-Congo Hemorrhagic Fever, Kosovo, 2013-2016. ( 30666932 )
2019
7
Crimean Congo hemorrhagic fever serosurvey in humans for identifying high-risk populations and high-risk areas in the endemic state of Gujarat, India. ( 30709372 )
2019
8
Immunoglobulin-like Domain of HsFcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies. ( 30709812 )
2019
9
Crimean-Congo hemorrhagic fever virus nucleocapsid protein harbors distinct RNA-binding sites in the stalk and head domains. ( 30723154 )
2019
10
Crimean-Congo hemorrhagic fever (CCHF) seroprevalence: A systematic review and meta-analysis. ( 31108083 )
2019
11
Survey of Crimean-Congo Hemorrhagic Fever Enzootic Focus, Spain, 2011-2015. ( 31107219 )
2019
12
Evaluation of Crimean-Congo Hemorrhagic Fever Orthonairovirus AviTaged Nucleoprotein for Potential Application in Diagnosis ( 31104398 )
2019
13
Diagnostic approaches for Crimean-Congo hemorrhagic fever virus. ( 31053042 )
2019
14
In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors. ( 31048746 )
2019
15
Identification of potential microRNA markers related to Crimean-Congo hemorrhagic fever disease. ( 31044455 )
2019
16
Persistence of IgG antibodies in survivors of Crimean Congo hemorrhagic fever virus infection, India. ( 31027886 )
2019
17
Clinical and molecular epidemiology of Crimean-Congo hemorrhagic fever in Oman. ( 31022170 )
2019
18
Lassa and Crimean-Congo Hemorrhagic Fever Viruses, Mali. ( 31002054 )
2019
19
Elevated Human Crimean-Congo Hemorrhagic Fever Virus Seroprevalence in Khashm el Girba, Eastern Sudan. ( 30994100 )
2019
20
Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice. ( 30947619 )
2019
21
Crimean Congo Hemorrhagic Fever in Eastern Turkey: Epidemiological and Clinical Evaluation ( 30938129 )
2019
22
Towards the first multi-epitope recombinant vaccine against Crimean-Congo hemorrhagic fever virus: A computer-aided vaccine design approach. ( 30928513 )
2019
23
The pulmonary findings of Crimean-Congo hemorrhagic fever patients with chest X-ray assessments. ( 30911987 )
2019
24
Apoptosis and its relation with clinical course in patients with crimean-congo hemorrhagic fever. ( 30905066 )
2019
25
Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR-/- Mice Models. ( 30857305 )
2019
26
Genotypic analysis of S segment of Crimean-Congo hemorrhagic fever virus in Turkey. ( 30203691 )
2019
27
Positivity of dengue and chikungunya among Crimean-Congo hemorrhagic fever-negative cases in India: 2013-2016. ( 30241948 )
2018
28
Dynamics of viral load in Crimean Congo hemorrhagic fever. ( 29091325 )
2018
29
Evaluation of the associations between endothelial dysfunction, inflammation and coagulation in Crimean-Congo hemorrhagic fever patients. ( 29159591 )
2018
30
Sequence Optimized Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection of Crimean-Congo Hemorrhagic Fever Virus. ( 29165231 )
2018
31
Analysis of codon usage bias of Crimean-Congo hemorrhagic fever virus and its adaptation to hosts. ( 29198972 )
2018
32
Second International Conference on Crimean-Congo Hemorrhagic Fever. ( 29199036 )
2018
33
A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies. ( 29330092 )
2018
34
Investigation of an isolated case of human Crimean-Congo hemorrhagic fever in Central Uganda, 2015. ( 29382607 )
2018
35
Phylodynamics of Crimean Congo hemorrhagic fever virus in South Russia. ( 29413882 )
2018
36
Host preferences support the prominent role of Hyalomma ticks in the ecology of Crimean-Congo hemorrhagic fever. ( 29420542 )
2018
37
Characteristics of headache and its relationship with disease severity in patients with Crimean-Congo hemorrhagic fever. ( 29450871 )
2018
38
Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China. ( 29520745 )
2018
39
Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China. ( 29524182 )
2018
40
Isolation and whole-genome sequencing of a Crimean-Congo hemorrhagic fever virus strain, Greece. ( 29525552 )
2018
41
Crimean-Congo Hemorrhagic Fever Virus and Borrelia burgdorferi sensu lato in Ticks from Kosovo and Albania. ( 29560357 )
2018
42
Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in μ-capture and IgG immune complex (IC) ELISA tests. ( 29579040 )
2018
43
Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient With CCHF Infection. ( 29584885 )
2018
44
Dynamic Modeling of Crimean Congo Hemorrhagic Fever Virus (CCHFV) Spread to Test Control Strategies. ( 29618023 )
2018
45
The role of Treg population in pathogenesis of Crimean Congo hemorrhagic fever. ( 29625147 )
2018
46
Mapping of B-cell epitopes on the N- terminal and C-terminal segment of nucleocapsid protein from Crimean-Congo hemorrhagic fever virus. ( 30235312 )
2018
47
Fine mapping epitope on glycoprotein-Gn from Crimean-Congo hemorrhagic fever virus. ( 30290884 )
2018
48
Emergency Department Response in Dealing with Crimean-Congo Hemorrhagic Fever Patients. ( 30320021 )
2018
49
Recent advances in understanding Crimean-Congo hemorrhagic fever virus. ( 30416710 )
2018
50
Crimean-Congo Hemorrhagic Fever Virus, Mongolia, 2013-2014. ( 30457521 )
2018

Variations for Crimean-Congo Hemorrhagic Fever

Expression for Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for Crimean-Congo Hemorrhagic Fever

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 CXCL10 IFNA17 IL6 TNF TREM1
2
Show member pathways
12.37 CXCL10 IFNA17 IL6 TNF
3
Show member pathways
12.07 CXCL10 IL6 TNF
4 11.94 IFNA17 IL6 TNF
5
Show member pathways
11.92 F3 IL6 TNF
6
Show member pathways
11.85 CXCL10 IL6 TNF
7 11.62 CXCL10 IL6 TNF
8 11.54 CXCL10 IL6 TNF
9 11.43 F3 IL6 TNF
10 11.15 IL6 TNF
11 11.12 IL6 TNF
12 11.07 IL6 TNF
13 11.04 IL6 TNF
14 11 IL6 TNF
15 10.98 CXCL10 IL6 TNF
16 10.93 CXCL10 IL6 TNF
17 10.82 IL6 TNF
18 10.71 IL6 TNF
19 10.49 CXCL10 IL6 TNF

GO Terms for Crimean-Congo Hemorrhagic Fever

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CHIT1 CXCL10 F3 IFNA17 IL6 PON1
2 extracellular space GO:0005615 9.23 CHIT1 CXCL10 F3 GPT IFNA17 IL6

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.78 CHIT1 CXCL10 IL6 TNF
2 defense response to virus GO:0051607 9.71 CXCL10 IFNA17 IL6
3 cellular response to lipopolysaccharide GO:0071222 9.67 CXCL10 IL6 TNF
4 regulation of signaling receptor activity GO:0010469 9.67 CXCL10 IFNA17 IL6 TNF
5 defense response GO:0006952 9.61 CXCL10 IFNA17 TNF
6 negative regulation of myoblast differentiation GO:0045662 9.52 CXCL10 TNF
7 negative regulation of neurogenesis GO:0050768 9.51 IL6 TNF
8 response to virus GO:0009615 9.5 CXCL10 IFNA17 TNF
9 positive regulation of chemokine production GO:0032722 9.46 IL6 TNF
10 positive regulation of glial cell proliferation GO:0060252 9.4 IL6 TNF
11 cytokine-mediated signaling pathway GO:0019221 9.35 CXCL10 F3 IFNA17 IL6 TNF
12 negative regulation of lipid storage GO:0010888 9.26 IL6 TNF
13 positive regulation of neuroinflammatory response GO:0150078 9.16 IL6 TNF
14 humoral immune response GO:0006959 8.92 IFNA17 IL6 TNF TREM1

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL10 IFNA17 IL6 TNF

Sources for Crimean-Congo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....