MCID: CRT009
MIFTS: 36

Critical Illness Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

MalaCards integrated aliases for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 12 15
Polyneuropathy, Critical Illness 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14402
ICD9CM 34 357.82
MeSH 44 D011115
SNOMED-CT 67 230594005
ICD10 32 G62.81
UMLS 70 C0393851

Summaries for Critical Illness Polyneuropathy

MalaCards based summary : Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and toxic shock syndrome. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways/superpathways are Selenium Micronutrient Network and AGE-RAGE signaling pathway in diabetic complications. The drugs Methyltestosterone and Testosterone undecanoate have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and liver, and related phenotype is immune system.

Wikipedia : 73 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

Related Diseases for Critical Illness Polyneuropathy

Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 521)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 31.5 TNF INS CRP ALB
2 toxic shock syndrome 30.6 TNF F3 CRP
3 endocarditis 30.2 TNF CRP ALB
4 peritonitis 30.2 TNF CRP ALB
5 lipid metabolism disorder 30.1 SELE INS CRP
6 mononeuropathy 30.0 TNF CRP ALB
7 appendicitis 30.0 TNF CRP ALB
8 respiratory failure 29.9 TNF GPT F3 CRP ALB
9 decubitus ulcer 29.8 TNF INS CRP ALB
10 kidney disease 29.6 TNF INS F3 CRP ALB
11 nephrotic syndrome 29.5 TNF F3 CRP ALB
12 peripheral nervous system disease 29.5 TNF INS GPT CRP ALB
13 bronchopneumonia 29.3 TNF GPT F3 CRP ALB
14 liver cirrhosis 29.0 TNF INS GPT F3 CRP ALB
15 myopathy 10.8
16 axonal neuropathy 10.5
17 quadriplegia 10.4
18 guillain-barre syndrome 10.3
19 neuropathy 10.3
20 malignant otitis externa 10.3 INS CRP
21 otitis externa 10.3 INS CRP
22 japanese spotted fever 10.3 CS CRP
23 hypoglycemia 10.3
24 encephalopathy 10.3
25 neuroretinitis 10.3 CS CRP
26 silent myocardial infarction 10.3 INS CRP
27 neurogenic arthropathy 10.3 INS CRP
28 chronic duodenal ileus 10.3 CRP ALB
29 severe nonproliferative diabetic retinopathy 10.3 INS ALB
30 endemic typhus 10.3 CS CRP
31 marasmus 10.3 INS ALB
32 kidney hypertrophy 10.3 INS ALB
33 peptic ulcer perforation 10.3 CRP ALB
34 cat-scratch disease 10.3 CS CRP
35 external ear disease 10.3 INS CRP
36 ankylosing spondylitis 3 10.3 CRP ALB
37 balanitis 10.3 INS CRP
38 acute insulin response 10.3 INS CRP
39 tuberculous peritonitis 10.3 CRP ALB
40 dipetalonemiasis 10.3 GPT ALB
41 mitochondrial pyruvate carrier deficiency 10.3 GPT CS
42 chronic intestinal vascular insufficiency 10.3 CRP ALB
43 afferent loop syndrome 10.3 GPT ALB
44 bartonellosis 10.3 CS CRP
45 duodenal obstruction 10.3 CRP ALB
46 type 1 diabetes mellitus 23 10.3 TNF INS
47 ocular motor apraxia 10.3
48 adult respiratory distress syndrome 10.3
49 splenic tuberculosis 10.3 CRP ALB
50 toxicodendron dermatitis 10.3 TNF SELE

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to Critical Illness Polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 ALB CRP F3 INS MSTN NFKBIZ

Drugs & Therapeutics for Critical Illness Polyneuropathy

Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
2
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
3
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
4
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
5 Hormones Phase 2, Phase 3
6 Antineoplastic Agents, Hormonal Phase 2, Phase 3
7 Hormone Antagonists Phase 2, Phase 3
8 Anabolic Agents Phase 2, Phase 3
9 Testosterone 17 beta-cypionate Phase 2, Phase 3
10 Androgens Phase 2, Phase 3
11 Immunoglobulins Phase 1
12 Immunologic Factors Phase 1
13 Rho(D) Immune Globulin Phase 1
14 gamma-Globulins Phase 1
15 Immunoglobulins, Intravenous Phase 1
16 Antibodies Phase 1
17 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Unknown status NCT02706587 Phase 3
2 Pilot Randomized, Controlled Trial of Testosterone Therapy in Chronic Critically Ill Patients and Its Potential Effects on Weaning From Mechanical Ventilation and Intensive Care Unit-acquired Weakness Unknown status NCT03038919 Phase 2, Phase 3 Testosterone cypionate
3 The Impact of Early Treatment With IgM-enriched IVIG on Critical Illness Polyneuropathy and/or Myopathy in Patients With Multiple Organ Failure and SIRS/Sepsis: A Prospective, Randomized, Placebo-controlled, Double-blinded Trial Terminated NCT01867645 Phase 1 IgM-enriched Intravenous Immunoglobulins;Human Albumin
4 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Unknown status NCT02763709
5 Effects of Early Stepping Verticalization With or Without FES Compared to Conventional Physiotherapy on the Occurrence of Critical Illness Polyneuropathy in Patients Affected by Acquired Brain Injury: a Retrospective Study Completed NCT03616314
6 Pilot Observation of the Impact of Human Blood Serum From Critically Ill Patients With or Without Critical-illness-polyneuropathy on Intramural Neuronal Networks of Human Colon Samples Completed NCT02706314
7 Validation Study of Simplified Electrophysiological Examination in the Diagnosis of Critical Illness Myopathy or Neuropathy Active, not recruiting NCT04193943
8 Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients. Active, not recruiting NCT03893058
9 Neuromuscular Electrical Stimulation in the Critically Ill Withdrawn NCT02566941

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

Anatomical Context for Critical Illness Polyneuropathy

MalaCards organs/tissues related to Critical Illness Polyneuropathy:

40
Kidney, Heart, Liver, Lung, Colon, Bone, Lymph Node

Publications for Critical Illness Polyneuropathy

Articles related to Critical Illness Polyneuropathy:

(show top 50) (show all 346)
# Title Authors PMID Year
1
Clinical and neurophysiological characterization of muscular weakness in severe COVID-19. 61
33755815 2021
2
Physiology in Medicine: Pathophysiology and management of critical illness polyneuropathy and myopathy. 61
33734888 2021
3
Investigating inpatient rehabilitation outcomes of patients with intensive care unit-acquired weakness, and identifying comorbidities associated with unfavorable outcomes. 61
33528114 2021
4
Potential neurological manifestations of COVID-19: a narrative review. 61
33089707 2021
5
COVID-19 related muscle denervation atrophy. 61
33517510 2021
6
Pain during and after COVID-19 in Germany and worldwide: a narrative review of current knowledge. 61
33490851 2021
7
Tracheostomy in patients with COVID-19: predictors and clinical features. 61
33386436 2021
8
Dysphagia in Patients With Severe Coronavirus Disease 2019-Potential Neurologic Etiologies. 61
33521647 2021
9
Simplified Diagnosis of Critical Illness Polyneuropathy in Patients with Prolonged Mechanical Ventilation: A Prospective Observational Cohort Study. 61
33322090 2020
10
The Ameliorative Effects of Ascorbic Acid on Critical Illness Polyneuropathy in Rodent Sepsis Model. 61
33133742 2020
11
Stiff-person syndrome coexisting with critical illness polyneuropathy: A case report. 61
33327330 2020
12
Critical illness polyneuromyopathy: Functional impact after severe acquired brain injuries. 61
32740902 2020
13
Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods. 61
33217953 2020
14
Single assessment of delirium severity during postacute intensive care of chronically critically ill patients and its associated factors: post hoc analysis of a prospective cohort study in Germany. 61
33033083 2020
15
Approach to critical illness myopathy and polyneuropathy in the older SARS-CoV-2 patients. 61
33070904 2020
16
Focal brain ischemia in mice does not cause electrophysiological signs of critical illness neuropathy. 61
32912287 2020
17
Reply to the Letter to Editor Regarding "An Unusual Case of Critical Illness Polyneuromyopathy". 61
32963453 2020
18
[Intensive Care During a Global Epidemic]. 61
32495323 2020
19
Critical Illness Neuropathy. 61
32358246 2020
20
Vitamin D serum level in subjects with critical illness polyneuropathy and myopathy. 61
32131367 2020
21
An Unusual Case of Critical Illness Polyneuromyopathy. 61
32205946 2020
22
Surgical treatment for Kommerell's diverticulum associated with aortic dissection involving aortic arch. 61
31475407 2019
23
Technology-aided leisure and communication support in extensive neuro-motor and communication impairments. 61
30370755 2019
24
Polyneuropathy in Critically Ill Mechanically Ventilated Children: Experience From a Tertiary Care Hospital in North India. 61
31348111 2019
25
Correspondence: Guillain-Barré syndrome and hemorrhagic fever with renal syndrome. 61
31382899 2019
26
Beta-thalassemia major complicated by intracranial hemorrhage and critical illness polyneuropathy. 61
31317877 2019
27
Critical Illness Polyneuropathy (CIP): a multicenter study on functional outcome. 61
30946550 2019
28
Pulmonary and Physical Rehabilitation in Critically Ill Patients. 61
31723900 2019
29
Intensive care unit-acquired weakness: unanswered questions and targets for future research. 61
31069055 2019
30
Central nervous system involvement in patients with critical illness polyneuropathy. 61
30508761 2019
31
Peripheral nerve disease secondary to systemic conditions in children. 61
31447934 2019
32
Muscle weakness associated with H7N9 infection: report of two cases. 61
30572825 2018
33
Neuromuscular electrical stimulation is ineffective for treating quadriceps muscle wasting with ruptured aneurysm: A case report. 61
30294437 2018
34
Effect of Transcutaneous Electrical Neuromuscular Stimulation on Myopathy in Intensive Care Patients. 61
30385541 2018
35
Neurophysiological study of critical illness polyneuropathy and myopathy in mechanically ventilated children; additional aspects in paediatric critical illness comorbidities. 61
29604150 2018
36
Effects of the use of neuromuscular blocking agents on acute respiratory distress syndrome outcomes: A systematic review. 61
29878965 2018
37
Electrodiagnostic studies in the intensive care unit: A comparison study 2 decades later. 61
29053882 2018
38
Fatigue in chronically critically ill patients following intensive care - reliability and validity of the multidimensional fatigue inventory (MFI-20). 61
29463245 2018
39
ICU-acquired weakness: should medical sovereignty belong to any specialist? 61
29301549 2018
40
Self-reported fatigue following intensive care of chronically critically ill patients: a prospective cohort study. 61
29744108 2018
41
Functional outcome of critical illness polyneuropathy in patients affected by severe brain injury. 61
28417610 2017
42
Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. 61
29019851 2017
43
Intensive Care Unit-Acquired Weakness. 61
28962810 2017
44
HeartMate 3 in Lowest INTERMACS Profile Cohort: The Swiss Experience. 61
28557861 2017
45
Risk Factors of Delayed Onset Posttraumatic Stress Disorder in Chronically Critically Ill Patients. 61
28682981 2017
46
[Critical illness myopathy and polyneuropathy]. 61
28875277 2017
47
Practical approach to the patient with acute neuromuscular weakness. 61
28798922 2017
48
[Prolonged weaning during early neurological and neurosurgical rehabilitation : S2k guideline published by the Weaning Committee of the German Neurorehabilitation Society (DGNR)]. 61
28484823 2017
49
Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure. 61
28091345 2017
50
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. 61
27856098 2017

Variations for Critical Illness Polyneuropathy

Expression for Critical Illness Polyneuropathy

Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for Critical Illness Polyneuropathy

Pathways related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.26 TNF INS CRP ALB
2 11.13 TNF SELE F3
3 10.54 TNF CRP
4 10.36 INS GPT

GO Terms for Critical Illness Polyneuropathy

Cellular components related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF SELE MSTN INS GPT F3

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 TNF INS F3 CRP
2 positive regulation of protein kinase B signaling GO:0051897 9.63 TNF INS F3
3 positive regulation of nitric-oxide synthase activity GO:0051000 9.43 TNF INS
4 negative regulation of myoblast differentiation GO:0045662 9.4 TNF MSTN
5 leukocyte tethering or rolling GO:0050901 9.32 TNF SELE
6 negative regulation of lipid catabolic process GO:0050995 9.26 TNF INS
7 inflammatory response GO:0006954 9.26 TNF SELE NFKBIZ CRP
8 regulation of protein secretion GO:0050708 9.16 TNF INS
9 negative regulation of lipid storage GO:0010888 8.62 TNF CRP

Molecular functions related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 TNF INS F3

Sources for Critical Illness Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....