MCID: CRT009
MIFTS: 31

Critical Illness Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

MalaCards integrated aliases for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 12 15
Polyneuropathy, Critical Illness 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14402
ICD9CM 36 357.82
MeSH 45 D011115
ICD10 34 G62.81
UMLS 74 C0393851

Summaries for Critical Illness Polyneuropathy

MalaCards based summary : Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and myopathy. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways/superpathways is Amino Acid metabolism. The drugs Testosterone undecanoate and Testosterone enanthate have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and colon.

Wikipedia : 77 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

Related Diseases for Critical Illness Polyneuropathy

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to Critical Illness Polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

Drugs & Therapeutics for Critical Illness Polyneuropathy

Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
2
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
3
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
4
Testosterone Approved, Experimental, Investigational Phase 2, Phase 3 58-22-0, 481-30-1 10204 6013
5
Zinc Approved, Investigational Phase 3 7440-66-6 32051
6
Dexmedetomidine Approved, Vet_approved Phase 3 113775-47-6 5311068 68602
7
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
8
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
9 Antineoplastic Agents, Hormonal Phase 2, Phase 3
10 Anabolic Agents Phase 2, Phase 3
11 Testosterone 17 beta-cypionate Phase 2, Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
13 Hormone Antagonists Phase 2, Phase 3
14 Testosterone Congeners Phase 2, Phase 3
15 Hormones Phase 2, Phase 3
16 Androgens Phase 2, Phase 3
17 insulin Phase 3
18 Insulin, Globin Zinc Phase 3
19 Hypoglycemic Agents Phase 3
20 Pharmaceutical Solutions Phase 3
21 Adrenergic Agents Phase 3
22 Adrenergic alpha-Agonists Phase 3
23 Neurotransmitter Agents Phase 3
24 Peripheral Nervous System Agents Phase 3
25 Analgesics, Non-Narcotic Phase 3
26 Central Nervous System Depressants Phase 3
27 Analgesics Phase 3
28 Adrenergic Agonists Phase 3
29 Hypnotics and Sedatives Phase 3
30 Adrenergic alpha-2 Receptor Agonists Phase 3
31 Immunoglobulins, Intravenous Phase 1
32 Antibodies Phase 1
33 Immunologic Factors Phase 1
34 Rho(D) Immune Globulin Phase 1
35 Immunoglobulins Phase 1
36 gamma-Globulins Phase 1
37 Cola
38 Anesthetics

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness Unknown status NCT03038919 Phase 2, Phase 3 Testosterone cypionate
2 Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Assessment Unknown status NCT02706587 Phase 3
3 Tight Glycemic Control in Critical Care Patients Completed NCT00096421 Phase 3
4 Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) Completed NCT00135473 Phase 3 10% Hemohes® (10% Hydroxyethyl starch);Sterofundin® (Ringer lactate solution);Actrapid® (Insulin)
5 Dexmedetomidine for Continuous Sedation Terminated NCT00226785 Phase 3 Dexmedetomidine
6 Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M) Completed NCT00614562 Phase 1
7 The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis Terminated NCT01867645 Phase 1 IgM-enriched Intravenous Immunoglobulins;Human Albumin
8 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Unknown status NCT02763709
9 Effects of Early Stepping Verticalization + FES on CIP Completed NCT03616314
10 Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks. Completed NCT02706314
11 Neurological Outcome in Surgical and Non-surgical Septic Patients Completed NCT02442986
12 Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients. Recruiting NCT03893058
13 Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock Recruiting NCT03258619
14 In-Bed Cycling in ICU Patients Post Cardiac Surgery Recruiting NCT02976415 Not Applicable
15 Amino Acid Metabolism in Fed Surgical Critically Ill Patients Active, not recruiting NCT03451968 Not Applicable
16 Metabolomics Study on Intensive Care Acquired Muscle Weakness in Polytrauma Not yet recruiting NCT03819959
17 Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness Not yet recruiting NCT03810768
18 Neuromuscular Electrical Stimulation in the Critically Ill Withdrawn NCT02566941 Not Applicable

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

Anatomical Context for Critical Illness Polyneuropathy

MalaCards organs/tissues related to Critical Illness Polyneuropathy:

42
Testes, Brain, Colon, Heart, Liver

Publications for Critical Illness Polyneuropathy

Articles related to Critical Illness Polyneuropathy:

(show top 50) (show all 133)
# Title Authors Year
1
Critical Illness Polyneuropathy (CIP): a multicenter study on functional outcome. ( 30946550 )
2019
2
Neurophysiological study of critical illness polyneuropathy and myopathy in mechanically ventilated children; additional aspects in paediatric critical illness comorbidities. ( 29604150 )
2018
3
Central nervous system involvement in patients with critical illness polyneuropathy. ( 30508761 )
2018
4
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. ( 27856098 )
2017
5
Functional outcome of critical illness polyneuropathy in patients affected by severe brain injury. ( 28417610 )
2017
6
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness MYOPATHIES. ( 26311145 )
2016
7
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. ( 27207148 )
2016
8
Acute Physiology and Chronic Health Evaluation II score of ≥15: A risk factor for sepsis-induced critical illness polyneuropathy. ( 27381107 )
2016
9
Critical illness polyneuropathy and myopathy 20 years later. No man's land? No, it is our land! ( 27502507 )
2016
10
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. ( 27932182 )
2016
11
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. ( 27978832 )
2016
12
Intensive care unit-related generalized neuromuscular weakness due to critical illness polyneuropathy/myopathy in critically ill patients. ( 24981564 )
2015
13
Dysphagia--a common, transient symptom in critical illness polyneuropathy: a fiberoptic endoscopic evaluation of swallowing study*. ( 25377021 )
2015
14
Dysphagia diagnosed by fiberoptic endoscopy is common and transient in critical illness polyneuropathy: are there any clinical implications? ( 25599480 )
2015
15
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy. ( 25916937 )
2015
16
Bilateral Diaphragmatic Paralysis in a Patient With Critical Illness Polyneuropathy: A Case Report. ( 26252301 )
2015
17
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. ( 26276515 )
2015
18
Is critical illness polyneuropathy associated with decreased heart rate variability? ( 24230479 )
2014
19
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. ( 24477672 )
2014
20
Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. ( 24678152 )
2014
21
A rare case of critical illness polyneuropathy and literature review. ( 24949002 )
2014
22
Critical illness polyneuropathy and myopathy: a systematic review. ( 25206749 )
2014
23
Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. ( 25309729 )
2014
24
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. ( 23373568 )
2013
25
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. Response. ( 23667929 )
2013
26
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. ( 24339610 )
2013
27
Critical illness polyneuropathy and myopathy are common neuromuscular complications secondary to sepsis. ( 22307447 )
2013
28
Strategies to prevent sepsis-induced intensive care unit-acquired weakness: are there any options? Commentary on "Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with surgically induced sepsis". ( 23295195 )
2013
29
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. ( 23312812 )
2013
30
Reversible tetraplegia after percutaneous nephrostolithotomy and septic shock: a case of critical illness polyneuropathy and myopathy with acute onset and complete recovery. ( 23409743 )
2013
31
Critical-illness-polyneuropathy as sequelae of severe neurological illness: incidence and impact on ventilator therapy and rehabilitation. ( 23422468 )
2013
32
Lower urinary tract dysfunction in critical illness polyneuropathy. ( 23949055 )
2013
33
Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. ( 24088271 )
2013
34
Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy--a single center controlled observational study. ( 24176121 )
2013
35
Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia. ( 22246161 )
2012
36
Successful management of critical illness polyneuropathy and myopathy in renal transplant recipients. ( 22309422 )
2012
37
The critical illness polyneuropathy in septic patients with prolonged weaning from mechanical ventilation: is the diaphragm also affected? A pilot study. ( 22417531 )
2012
38
Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. ( 23094903 )
2012
39
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review. ( 23158890 )
2012
40
Therapeutic effect of insulin in reducing critical illness; polyneuropathy and myopathy in the pediatric intensive care unit. ( 24665266 )
2012
41
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. ( 21939902 )
2011
42
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? ( 22018206 )
2011
43
Rehabilitation of critical illness polyneuropathy and myopathy patients: an observational study. ( 22067549 )
2011
44
Critical illness polyneuropathy: a case report. ( 22142755 )
2011
45
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. ( 19760771 )
2010
46
Critical illness polyneuropathy after septic peritonitis in a boy with nephrotic syndrome. ( 20232085 )
2010
47
Electrical muscle stimulation for prevention of critical illness polyneuropathy. ( 20624326 )
2010
48
The discovery of critical illness polyneuropathy: a memoir. ( 20724249 )
2010
49
Management of critical illness polyneuropathy and myopathy. ( 20816273 )
2010
50
Critical illness polyneuropathy in patients with major burn injuries. ( 21119768 )
2010

Variations for Critical Illness Polyneuropathy

Expression for Critical Illness Polyneuropathy

Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for Critical Illness Polyneuropathy

Pathways related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 CS PNMT

GO Terms for Critical Illness Polyneuropathy

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 8.62 CS INS

Sources for Critical Illness Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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