MCID: CRT009
MIFTS: 31

Critical Illness Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

MalaCards integrated aliases for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 12 15
Polyneuropathy, Critical Illness 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14402
ICD10 33 G62.81
ICD9CM 35 357.82
MeSH 44 D011115
UMLS 73 C0393851

Summaries for Critical Illness Polyneuropathy

MalaCards based summary : Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and myopathy. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways/superpathways is Amino Acid metabolism. The drugs Testosterone and Testosterone enanthate have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and heart, and related phenotype is hearing/vestibular/ear.

Wikipedia : 76 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

Related Diseases for Critical Illness Polyneuropathy

Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 10.9
2 myopathy 10.7
3 neuropathy 10.2
4 respiratory failure 10.1
5 encephalopathy 10.1
6 leukemia, acute lymphoblastic 10.0
7 leukemia 10.0
8 lymphocytic leukemia 10.0
9 axonal neuropathy 10.0
10 acute respiratory distress syndrome 10.0
11 dysphagia 10.0
12 inflammatory and toxic neuropathy 9.9 INS SCN4A
13 graves disease 1 9.9 INS SCN4A
14 hypokalemic periodic paralysis, type 1 9.9 INS SCN4A
15 myasthenia gravis 9.9
16 polyglucosan body myopathy 1 with or without immunodeficiency 9.9
17 brain injury 9.9
18 infective endocarditis 9.9
19 endocarditis 9.9
20 nephrotic syndrome 9.9
21 quadriplegia 9.9
22 beriberi 9.9
23 peritonitis 9.9
24 appendicitis 9.9
25 encephalitis 9.9
26 myasthenia gravis congenital 9.9
27 muscular disease 9.8 INS SCN4A
28 hypertension, essential 9.8 INS PNMT

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to Critical Illness Polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 8.8 CS POLB SCN4A

Drugs & Therapeutics for Critical Illness Polyneuropathy

Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
2
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
3
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
4
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
5
Zinc Approved, Investigational Phase 3 7440-66-6
6
Dexmedetomidine Approved, Vet_approved Phase 3 113775-47-6 68602 5311068
7
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
8
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
9 Antineoplastic Agents, Hormonal Phase 2, Phase 3
10 Hormone Antagonists Phase 2, Phase 3
11 Androgens Phase 2, Phase 3
12 Testosterone Congeners Phase 2, Phase 3
13 Hormones Phase 2, Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
15 Testosterone 17 beta-cypionate Phase 2, Phase 3
16 Anabolic Agents Phase 2, Phase 3
17 Insulin, Globin Zinc Phase 3
18 insulin Phase 3
19 Pharmaceutical Solutions Phase 3
20 Hypoglycemic Agents Phase 3
21 Analgesics Phase 3
22 Adrenergic alpha-Agonists Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Neurotransmitter Agents Phase 3
25 Adrenergic Agonists Phase 3
26 Hypnotics and Sedatives Phase 3
27 Adrenergic alpha-2 Receptor Agonists Phase 3
28 Adrenergic Agents Phase 3
29 Analgesics, Non-Narcotic Phase 3
30 Central Nervous System Depressants Phase 3
31 gamma-Globulins Phase 1
32 Immunoglobulins, Intravenous Phase 1
33 Immunologic Factors Phase 1
34 Immunoglobulins Phase 1
35 Rho(D) Immune Globulin Phase 1
36 Antibodies Phase 1
37 Anesthetics
38 Cola

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness Unknown status NCT03038919 Phase 2, Phase 3 Testosterone cypionate
2 Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Assessment Unknown status NCT02706587 Phase 3
3 Tight Glycemic Control in Critical Care Patients Completed NCT00096421 Phase 3
4 Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) Completed NCT00135473 Phase 3 10% Hemohes® (10% Hydroxyethyl starch);Sterofundin® (Ringer lactate solution);Actrapid® (Insulin)
5 Dexmedetomidine for Continuous Sedation Terminated NCT00226785 Phase 3 Dexmedetomidine
6 Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M) Completed NCT00614562 Phase 1
7 The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis Terminated NCT01867645 Phase 1 IgM-enriched Intravenous Immunoglobulins;Human Albumin
8 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Unknown status NCT02763709
9 Effects of Early Stepping Verticalization + FES on CIP Completed NCT03616314
10 Neurological Outcome in Surgical and Non-surgical Septic Patients Completed NCT02442986
11 Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks. Recruiting NCT02706314
12 Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock Recruiting NCT03258619
13 In-Bed Cycling in ICU Patients Post Cardiac Surgery Recruiting NCT02976415 Not Applicable
14 Amino Acid Metabolism in Fed Surgical Critically Ill Patients Active, not recruiting NCT03451968 Not Applicable
15 Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness Not yet recruiting NCT03810768
16 Neuromuscular Electrical Stimulation in the Critically Ill Withdrawn NCT02566941 Not Applicable

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

Anatomical Context for Critical Illness Polyneuropathy

MalaCards organs/tissues related to Critical Illness Polyneuropathy:

41
Testes, Liver, Heart, Brain, Lung, Colon

Publications for Critical Illness Polyneuropathy

Articles related to Critical Illness Polyneuropathy:

(show top 50) (show all 133)
# Title Authors Year
1
Neurophysiological study of critical illness polyneuropathy and myopathy in mechanically ventilated children; additional aspects in paediatric critical illness comorbidities. ( 29604150 )
2018
2
Central nervous system involvement in patients with critical illness polyneuropathy. ( 30508761 )
2018
3
Functional outcome of critical illness polyneuropathy in patients affected by severe brain injury. ( 28417610 )
2017
4
Acute Physiology and Chronic Health Evaluation II score of a8Y15: A risk factor for sepsis-induced critical illness polyneuropathy. ( 27381107 )
2016
5
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. ( 27978832 )
2016
6
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. ( 27207148 )
2016
7
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. ( 27856098 )
2016
8
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. ( 27932182 )
2016
9
Critical illness polyneuropathy and myopathy 20A years later. No man's land? No, it is our land! ( 27502507 )
2016
10
Dysphagia diagnosed by fiberoptic endoscopy is common and transient in critical illness polyneuropathy: are there any clinical implications? ( 25599480 )
2015
11
513: CRITICAL ILLNESS POLYNEUROPATHY AND MYOPATHY IN THE PICU. ( 26570174 )
2015
12
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. ( 26276515 )
2015
13
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness myopathy. ( 26311145 )
2015
14
Bilateral Diaphragmatic Paralysis in a Patient With Critical Illness Polyneuropathy: A Case Report. ( 26252301 )
2015
15
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy. ( 25916937 )
2015
16
Dysphagia-A Common, Transient Symptom in Critical Illness Polyneuropathy: A Fiberoptic Endoscopic Evaluation of Swallowing Study. ( 25377021 )
2014
17
A rare case of critical illness polyneuropathy and literature review. ( 24949002 )
2014
18
Critical illness polyneuropathy and myopathy: a systematic review. ( 25206749 )
2014
19
Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. ( 25309729 )
2014
20
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. ( 24477672 )
2014
21
Intensive care unit-related generalized neuromuscular weakness due to critical illness polyneuropathy/myopathy in critically ill patients. ( 24981564 )
2014
22
Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. ( 24678152 )
2014
23
Reversible tetraplegia after percutaneous nephrostolithotomy and septic shock: a case of critical illness polyneuropathy and myopathy with acute onset and complete recovery. ( 23409743 )
2013
24
Lower urinary tract dysfunction in critical illness polyneuropathy. ( 23949055 )
2013
25
Is critical illness polyneuropathy associated with decreased heart rate variability? ( 24230479 )
2013
26
Critical illness polyneuropathy and myopathy are common neuromuscular complications secondary to sepsis. ( 22307447 )
2013
27
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. ( 23312812 )
2013
28
Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy - a single center controlled observational study. ( 24176121 )
2013
29
Critical-illness-polyneuropathy as sequelae of severe neurological illness: incidence and impact on ventilator therapy and rehabilitation. ( 23422468 )
2013
30
Strategies to prevent sepsis-induced intensive care unit-acquired weakness: are there any options? Commentary on "Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with surgically induced sepsis". ( 23295195 )
2013
31
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. Response. ( 23667929 )
2013
32
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. ( 24339610 )
2013
33
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. ( 23373568 )
2013
34
Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. ( 24088271 )
2013
35
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review. ( 23158890 )
2012
36
Successful management of critical illness polyneuropathy and myopathy in renal transplant recipients. ( 22309422 )
2012
37
Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia. ( 22246161 )
2012
38
Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. ( 23094903 )
2012
39
The critical illness polyneuropathy in septic patients with prolonged weaning from mechanical ventilation: is the diaphragm also affected? A pilot study. ( 22417531 )
2012
40
Therapeutic effect of insulin in reducing critical illness; polyneuropathy and myopathy in the pediatric intensive care unit. ( 24665266 )
2012
41
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. ( 21939902 )
2011
42
Rehabilitation of critical illness polyneuropathy and myopathy patients: an observational study. ( 22067549 )
2011
43
Critical illness polyneuropathy: a case report. ( 22142755 )
2011
44
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? ( 22018206 )
2011
45
Electrical muscle stimulation for prevention of critical illness polyneuropathy. ( 20624326 )
2010
46
Critical illness polyneuropathy in patients with major burn injuries. ( 21119768 )
2010
47
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. ( 19760771 )
2010
48
Management of critical illness polyneuropathy and myopathy. ( 20816273 )
2010
49
Critical illness polyneuropathy after septic peritonitis in a boy with nephrotic syndrome. ( 20232085 )
2010
50
The discovery of critical illness polyneuropathy: a memoir. ( 20724249 )
2010

Variations for Critical Illness Polyneuropathy

Expression for Critical Illness Polyneuropathy

Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for Critical Illness Polyneuropathy

Pathways related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 CS PNMT

GO Terms for Critical Illness Polyneuropathy

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 8.62 CS INS

Sources for Critical Illness Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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