MCID: CRT009
MIFTS: 32

Critical Illness Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

MalaCards integrated aliases for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 12 15
Polyneuropathy, Critical Illness 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14402
ICD9CM 34 357.82
MeSH 43 D011115
ICD10 32 G62.81
UMLS 71 C0393851

Summaries for Critical Illness Polyneuropathy

MalaCards based summary : Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and peripheral nervous system disease. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase). The drugs Antibodies and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and liver, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

Related Diseases for Critical Illness Polyneuropathy

Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 31.7 INS CRP ALB
2 peripheral nervous system disease 30.1 INS CRP ALB
3 decubitus ulcer 30.0 INS CRP ALB
4 lipid metabolism disorder 29.8 SELE INS CRP
5 hypokalemia 29.7 SCN4A INS ALB
6 bronchopneumonia 29.4 P3H2 CRP ALB
7 myopathy 10.7
8 neuroretinitis 10.4 CS CRP
9 malignant otitis externa 10.4 INS CRP
10 severe nonproliferative diabetic retinopathy 10.4 INS ALB
11 marasmus 10.4 INS ALB
12 neurogenic arthropathy 10.4 INS CRP
13 silent myocardial infarction 10.4 INS CRP
14 kidney hypertrophy 10.4 INS ALB
15 cat-scratch disease 10.4 CS CRP
16 endemic typhus 10.4 CS CRP
17 acute insulin response 10.4 INS CRP
18 bartonellosis 10.4 CS CRP
19 toxic shock syndrome 10.4
20 axonal neuropathy 10.4
21 neuropathy 10.4
22 chronic duodenal ileus 10.4 CRP ALB
23 background diabetic retinopathy 10.4 INS ALB
24 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.3 INS CRP
25 necrotizing gastritis 10.3 CRP ALB
26 peptic ulcer perforation 10.3 CRP ALB
27 tuberculous peritonitis 10.3 CRP ALB
28 splenic abscess 10.3 CRP ALB
29 ascending cholangitis 10.3 CRP ALB
30 epidural abscess 10.3 CRP ALB
31 asphyxia neonatorum 10.3 INS CRP
32 acalculous cholecystitis 10.3 CRP ALB
33 granulomatous hepatitis 10.3 CRP ALB
34 gastrointestinal tuberculosis 10.3 CRP ALB
35 intestinal tuberculosis 10.3 CRP ALB
36 aspiration pneumonitis 10.3 CRP ALB
37 klebsiella pneumonia 10.3 CRP ALB
38 acute cholangitis 10.3 CRP ALB
39 abdominal tuberculosis 10.3 CRP ALB
40 quadriplegia 10.3
41 heart aneurysm 10.3 CRP ALB
42 hydrops of gallbladder 10.3 CRP ALB
43 paralytic ileus 10.3 CRP ALB
44 coronary aneurysm 10.3 CRP ALB
45 hypertensive retinopathy 10.3 CRP ALB
46 active peptic ulcer disease 10.3 CRP ALB
47 toxic megacolon 10.3 CRP ALB
48 pyuria 10.3 CRP ALB
49 lung abscess 10.3 CRP ALB
50 common bile duct disease 10.3 CRP ALB

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to Critical Illness Polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 ALB CRP CS INS NFKBIZ NPPC

Drugs & Therapeutics for Critical Illness Polyneuropathy

Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1
2 Immunologic Factors Phase 1
3 Rho(D) Immune Globulin Phase 1
4 Immunoglobulins Phase 1
5 Immunoglobulins, Intravenous Phase 1
6 gamma-Globulins Phase 1
7
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
8
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
9
Midazolam Approved, Illicit 59467-70-8 4192
10
tannic acid Approved 1401-55-4
11
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
12 Hematinics
13 Liver Extracts
14 Cola
15 Anesthetics
16 Anti-Anxiety Agents
17 Tranquilizing Agents
18 Neurotransmitter Agents
19 Adrenergic Agonists
20 Hypnotics and Sedatives
21 Adrenergic alpha-2 Receptor Agonists
22 Anesthetics, General
23 Analgesics, Non-Narcotic
24 Psychotropic Drugs
25 Adjuvants, Anesthesia
26 GABA Agents
27 Anesthetics, Intravenous
28 Central Nervous System Depressants
29 GABA Modulators
30 Adrenergic Agents
31 Analgesics

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Unknown status NCT02706587 Phase 3
2 The Impact of Early Treatment With IgM-enriched IVIG on Critical Illness Polyneuropathy and/or Myopathy in Patients With Multiple Organ Failure and SIRS/Sepsis: A Prospective, Randomized, Placebo-controlled, Double-blinded Trial Terminated NCT01867645 Phase 1 IgM-enriched Intravenous Immunoglobulins;Human Albumin
3 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Unknown status NCT02763709
4 Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock Unknown status NCT03258619
5 Effects of Early Stepping Verticalization With or Without FES Compared to Conventional Physiotherapy on the Occurrence of Critical Illness Polyneuropathy in Patients Affected by Acquired Brain Injury: a Retrospective Study Completed NCT03616314
6 Prospective Observational Study: Comparison of Neurological Outcome in Septic Surgical, Septic Non-surgical and Non-septic Patients on ICU Completed NCT02442986
7 The Safety and Efficacy of Early Rehabilitation Program in Immediate Liver Transplant Patients Completed NCT03529656
8 Pilot Observation of the Impact of Human Blood Serum From Critically Ill Patients With or Without Critical-illness-polyneuropathy on Intramural Neuronal Networks of Human Colon Samples Completed NCT02706314
9 Safety and Efficacy of an Early Rehabilitation Program in Surgical Intensive Care Unit (SICU) Completed NCT03055949
10 The Diagnosis and Incidence of Critical Illness Polyneuromyopathy in Medical and Neurosurgical ICU Patients Completed NCT02634658
11 Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy: a Pilot Randomized Controlled Study. Recruiting NCT04076826 Dexmedetomidine;Propofol or Midazolam
12 Case-observation and Compassionate Use: Use of Extracorporeal Treatment With the Cytosorb-Adsorber for the Reduction of Postoperative Hyperinflammation and SIRS After Heart-surgery With the Use of a Heart-lung-machine Recruiting NCT02265419
13 Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients. Recruiting NCT03893058
14 Piloting an ICU Follow-up Clinic to Improve Health Related Quality of Life After a Prolonged Intensive Care Stay Recruiting NCT04186468
15 Validation Study of Simplified Electrophysiological Examination in the Diagnosis of Critical Illness Myopathy or Neuropathy Active, not recruiting NCT04193943
16 Twenty Four Hours Amino Acid Metabolism in Fed Surgical Critically Ill Patients: a Stable Isotope Tracer Study. Active, not recruiting NCT03451968
17 Neuromuscular Electrical Stimulation in the Critically Ill Withdrawn NCT02566941

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

Anatomical Context for Critical Illness Polyneuropathy

MalaCards organs/tissues related to Critical Illness Polyneuropathy:

40
Heart, Testes, Liver, Lung, Bone, Brain, Kidney

Publications for Critical Illness Polyneuropathy

Articles related to Critical Illness Polyneuropathy:

(show top 50) (show all 325)
# Title Authors PMID Year
1
Surgical treatment for Kommerell's diverticulum associated with aortic dissection involving aortic arch. 61
31475407 2019
2
Technology-aided leisure and communication support in extensive neuro-motor and communication impairments. 61
30370755 2019
3
Polyneuropathy in Critically Ill Mechanically Ventilated Children: Experience From a Tertiary Care Hospital in North India. 61
31348111 2019
4
Correspondence: Guillain-Barré syndrome and hemorrhagic fever with renal syndrome. 61
31382899 2019
5
Beta-thalassemia major complicated by intracranial hemorrhage and critical illness polyneuropathy. 61
31317877 2019
6
Critical Illness Polyneuropathy (CIP): a multicenter study on functional outcome. 61
30946550 2019
7
Pulmonary and Physical Rehabilitation in Critically Ill Patients. 61
31723900 2019
8
Intensive care unit-acquired weakness: unanswered questions and targets for future research. 61
31069055 2019
9
Central nervous system involvement in patients with critical illness polyneuropathy. 61
30508761 2019
10
Peripheral nerve disease secondary to systemic conditions in children. 61
31447934 2019
11
Muscle weakness associated with H7N9 infection: report of two cases. 61
30572825 2018
12
Neuromuscular electrical stimulation is ineffective for treating quadriceps muscle wasting with ruptured aneurysm: A case report. 61
30294437 2018
13
Effect of Transcutaneous Electrical Neuromuscular Stimulation on Myopathy in Intensive Care Patients. 61
30385541 2018
14
Neurophysiological study of critical illness polyneuropathy and myopathy in mechanically ventilated children; additional aspects in paediatric critical illness comorbidities. 61
29604150 2018
15
Effects of the use of neuromuscular blocking agents on acute respiratory distress syndrome outcomes: A systematic review. 61
29878965 2018
16
Electrodiagnostic studies in the intensive care unit: A comparison study 2 decades later. 61
29053882 2018
17
Fatigue in chronically critically ill patients following intensive care - reliability and validity of the multidimensional fatigue inventory (MFI-20). 61
29463245 2018
18
Self-reported fatigue following intensive care of chronically critically ill patients: a prospective cohort study. 61
29744108 2018
19
ICU-acquired weakness: should medical sovereignty belong to any specialist? 61
29301549 2018
20
Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. 61
29019851 2017
21
Functional outcome of critical illness polyneuropathy in patients affected by severe brain injury. 61
28417610 2017
22
HeartMate 3 in Lowest INTERMACS Profile Cohort: The Swiss Experience. 61
28557861 2017
23
Intensive Care Unit-Acquired Weakness. 61
28962810 2017
24
Risk Factors of Delayed Onset Posttraumatic Stress Disorder in Chronically Critically Ill Patients. 61
28682981 2017
25
[Critical illness myopathy and polyneuropathy]. 61
28875277 2017
26
Practical approach to the patient with acute neuromuscular weakness. 61
28798922 2017
27
[Prolonged weaning during early neurological and neurosurgical rehabilitation : S2k guideline published by the Weaning Committee of the German Neurorehabilitation Society (DGNR)]. 61
28484823 2017
28
Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure. 61
28091345 2017
29
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. 61
27856098 2017
30
Outcome of neurological early rehabilitation patients carrying multi-drug resistant bacteria: results from a German multi-center study. 61
28320357 2017
31
Nervous System Abnormalities and Legionnaire's Disease. 61
27979685 2017
32
Influence of early neurological complications on clinical outcome following lung transplant. 61
28301586 2017
33
Review of Critical Illness Myopathy and Neuropathy. 61
28042370 2017
34
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. 61
27207148 2016
35
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. 61
27978832 2016
36
Peripheral nerve conduction abnormalities precede morphological alterations in an experimental rat model of sepsis. 61
27612852 2016
37
Critical illness polyneuropathy and myopathy 20 years later. No man's land? No, it is our land! 61
27502507 2016
38
Neuromuscular Blocking Agents and Neuromuscular Dysfunction Acquired in Critical Illness: A Systematic Review and Meta-Analysis. 61
27513545 2016
39
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. 61
27932182 2016
40
Physical rehabilitation interventions for adult patients during critical illness: an overview of systematic reviews. 61
27220357 2016
41
Acute Physiology and Chronic Health Evaluation II score of ≥15: A risk factor for sepsis-induced critical illness polyneuropathy. 61
27381107 2016
42
Pharmacological Therapy for the Prevention and Treatment of Weakness After Critical Illness: A Systematic Review. 61
26958749 2016
43
Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. 61
27025938 2016
44
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness MYOPATHIES. 61
26311145 2016
45
The impairment of small nerve fibers in severe sepsis and septic shock. 61
26984636 2016
46
[Critical illness polyneuropathy and myopathy as neurological complications of sepsis]. 61
26842898 2016
47
Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature. 61
27239356 2016
48
Critical illness myopathy in a cervical spine-injured patient. 61
28053761 2016
49
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. 61
26276515 2015
50
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy. 61
25916937 2015

Variations for Critical Illness Polyneuropathy

Expression for Critical Illness Polyneuropathy

Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for Critical Illness Polyneuropathy

GO Terms for Critical Illness Polyneuropathy

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of blood vessel diameter GO:0097755 9.16 NPPC INS
2 negative regulation of blood vessel diameter GO:0097756 8.96 INS CRP
3 negative regulation of protein oligomerization GO:0032460 8.62 INS ALB

Sources for Critical Illness Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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