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MCID: CRH005
MIFTS: 53

Crohn's Colitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Crohn's Colitis

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MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis 12 15
Crohn Disease 44 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:0060192
ICD10 33 K50.1
ICD9CM 35 555.1
MeSH 44 D003424
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Summaries for Crohn's Colitis

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Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary : Crohn's Colitis, also known as crohn disease, is related to crohn's disease and jejunoileitis, and has symptoms including diarrhea, rectal bleeding and skin lesions. An important gene associated with Crohn's Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon only, colon and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Crohn's Colitis

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Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 33.4 IL1B NOD2 TNF
2 jejunoileitis 30.9 IL1B TNF
3 ileocolitis 30.2 NOD2 TNF
4 central nervous system vasculitis 30.1 IL1B TNF
5 hidradenitis suppurativa 30.1 NOD2 TNF
6 vaginitis 30.1 CXCL8 IL1B
7 hidradenitis 30.0 NOD2 TNF
8 pneumonia 29.9 CXCL8 IL1B TNF
9 pyelonephritis 29.8 CXCL8 IL1B TNF
10 appendicitis 29.8 CXCL8 IL1B TNF
11 blau syndrome 29.8 IL1B NOD2 TNF
12 peritonitis 29.7 CXCL8 IL1B TNF
13 pyoderma gangrenosum 29.7 CXCL8 NOD2 TNF
14 pyoderma 29.7 CXCL8 NOD2 TNF
15 psoriatic arthritis 29.7 IL1B NOD2 TNF
16 chronic granulomatous disease 29.6 IFNG IL1B TNF
17 hemorrhagic fever 29.5 IFNG TNF
18 dengue hemorrhagic fever 29.4 CXCL8 IFNG TNF
19 wegener granulomatosis 29.3 CXCL8 IFNG TNF
20 ulcerative colitis 29.3 CXCL8 IL1B IL2 NOD2 TNF
21 arthritis 29.2 CXCL8 IFNG IL1B TNF
22 monocytic leukemia 29.1 CXCL8 IFNG IL1B TNF
23 spondyloarthropathy 29.0 IFNG IL2 TNF
24 pulmonary sarcoidosis 29.0 IFNG IL2 TNF
25 osteomyelitis 28.9 CXCL8 IFNG IL1B TNF
26 psoriasis 28.6 CXCL8 IFNG IL1B IL2 TNF
27 pleurisy 28.5 CXCL8 IFNG IL2 TNF
28 rheumatoid arthritis 27.9 CXCL8 IFNG IL1B IL2 TNF
29 colitis 27.3 CXCL8 IFNG IL1B IL2 NOD2 NOS2
30 diabetes mellitus 27.0 IFNG IL1B IL2 TNF
31 inflammatory bowel disease 26.3 CXCL8 IFNG IL1B IL2 NOD2 NOS2
32 inflammatory bowel disease 1 11.8
33 thiopurines, poor metabolism of, 1 11.1
34 inflammatory bowel disease 10 10.9
35 inflammatory bowel disease 13 10.9
36 inflammatory bowel disease 14 10.9
37 inflammatory bowel disease 17 10.9
38 inflammatory bowel disease 19 10.9
39 inflammatory bowel disease 25, autosomal recessive 10.9
40 inflammatory bowel disease 28, autosomal recessive 10.9
41 recurrent corneal erosion 10.8 CXCL8 IL1B
42 bagassosis 10.8 CXCL8 IL1B
43 bile acid malabsorption, primary 10.8
44 autoimmune disease 6 10.8
45 short bowel syndrome 10.8
46 peptic esophagitis 10.8 CXCL8 IL1B
47 funisitis 10.8 CXCL8 IL1B
48 systemic onset juvenile idiopathic arthritis 10.7 IL1B TNF
49 opisthorchiasis 10.7 CXCL8 IL1B
50 pouchitis 10.7 CXCL8 NOD2

Graphical network of the top 20 diseases related to Crohn's Colitis:



Diseases related to Crohn's Colitis
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Symptoms & Phenotypes for Crohn's Colitis

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Symptoms:

12
  • • diarrhea
  • • rectal bleeding
  • • skin lesions
  • • formation of ulcers

UMLS symptoms related to Crohn's Colitis:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Crohn's Colitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 IL2 NOD2 NOS2 TNF CXCL8 IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 IL2 NOD2 NOS2 TNF CXCL8 IL1B

MGI Mouse Phenotypes related to Crohn's Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 NOS2 IFNG SLIT2 IL1B TNF IL2
2 digestive/alimentary MP:0005381 9.95 IFNG SLIT2 TNF IL2 CDH1 NOD2
3 growth/size/body region MP:0005378 9.92 NOS2 IFNG SLIT2 IL1B TNF IL2
4 endocrine/exocrine gland MP:0005379 9.91 CDH3 NOS2 IFNG SLIT2 TNF IL2
5 immune system MP:0005387 9.8 TNF NOS2 IFNG IL1B IL2 NOD2
6 integument MP:0010771 9.7 CDH3 NOS2 IFNG SLIT2 IL1B TNF
7 mortality/aging MP:0010768 9.56 NOS2 IFNG SLIT2 IL1B TNF IL2
8 neoplasm MP:0002006 9.1 IFNG IL1B TNF IL2 CDH1 NOS2
Sources

Drugs & Therapeutics for Crohn's Colitis

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Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Ciprofloxacin Approved, Investigational Phase 4,Phase 2 85721-33-1 2764
5
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
6
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
7
Vancomycin Approved Phase 4 1404-90-6 441141 14969
8 Antiemetics Phase 4
9 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
10 Autonomic Agents Phase 4
11 Gastrointestinal Agents Phase 4
12 glucocorticoids Phase 4
13 Hormone Antagonists Phase 4
14 Hormones Phase 4
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
16 Methylprednisolone acetate Phase 4
17 Methylprednisolone Hemisuccinate Phase 4
18 Neuroprotective Agents Phase 4
19 Peripheral Nervous System Agents Phase 4,Phase 2
20 Prednisolone acetate Phase 4
21 Prednisolone hemisuccinate Phase 4
22 Prednisolone phosphate Phase 4
23 Protective Agents Phase 4
24 Anti-Bacterial Agents Phase 4,Phase 2
25 Antibiotics, Antitubercular Phase 4,Phase 2
26 Anti-Infective Agents Phase 4,Phase 2
27 Antimalarials Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Antiparasitic Agents Phase 4,Phase 2
30 Antiprotozoal Agents Phase 4,Phase 2
31 Antitubercular Agents Phase 4
32 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2
33 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
34 Gentamicins Phase 4
35 Topoisomerase Inhibitors Phase 4,Phase 2
36
Azathioprine Approved Phase 3,Phase 2 446-86-6 2265
37
Certolizumab pegol Approved Phase 3 428863-50-7
38
Adalimumab Approved Phase 3 331731-18-1 16219006
39 Antimetabolites Phase 3,Phase 2
40 Antimetabolites, Antineoplastic Phase 3,Phase 2
41 Antirheumatic Agents Phase 3,Phase 2
42 Immunosuppressive Agents Phase 3,Phase 2
43
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
44 Analgesics Phase 2
45 Analgesics, Non-Narcotic Phase 2
46 Angiogenesis Inhibitors Phase 2
47 Angiogenesis Modulating Agents Phase 2
48 Anti-Inflammatory Agents, Non-Steroidal Phase 2
49 Cola Nutraceutical Phase 2,Not Applicable
50 Antibodies Phase 1

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Manipulating the Microbiome in IBD by Antibiotics and FMT Active, not recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
2 Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease Unknown status NCT01817972 Phase 3 Azathioprine
3 Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease Recruiting NCT02914561 Phase 3 Filgotinib;Placebo to match filgotinib
4 Open-Label Extension and Safety Study for Patients With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144 Recruiting NCT02403323 Phase 3 etrolizumab
5 A Study to Assess Whether Etrolizumab is a Safe and Effective Treatment for Participants With Moderately to Severely Active Crohn's Disease (CD) Recruiting NCT02394028 Phase 3 Etrolizumab;Placebo
6 Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies Recruiting NCT02118584 Phase 3 Etrolizumab
7 A Study of the Efficacy and Safety of Etrolizumab in Ulcerative Colitis Participants Who Have Been Previously Exposed to Tumor Necrosis Factor (TNF) Inhibitors Recruiting NCT02100696 Phase 3 Etrozulimab;Placebo
8 Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Ulcerative Colitis Recruiting NCT02914522 Phase 3 Filgotinib;Placebo to match filgotinib
9 BI 695501 Versus Humira in Patients With Active Crohn's Disease: a Trial Comparing Efficacy, Endoscopic Improvement, Safety, and Immunogenicity Active, not recruiting NCT02871635 Phase 3 BI 695501;HUMIRA
10 Filgotinib in Long-Term Extension Study of Adults With Crohn's Disease Enrolling by invitation NCT02914600 Phase 3 Filgotinib;Placebo
11 Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis Enrolling by invitation NCT02914535 Phase 3 Filgotinib;Placebo
12 Efficacy and Safety Study of Mongersen (GED-0301) for the Treatment of Subjects With Active Crohn's Disease Terminated NCT02596893 Phase 3 GED-0301;Placebo
13 A Long-term Active Treatment Study of Mongersen (GED-0301) in Subjects With Crohn's Disease Terminated NCT02641392 Phase 3 GED-0301
14 A Study of Efficacy and Safety of Mongersen (GED-0301) for the Treatment of Adult and Adolescent Subjects With Active Crohn's Disease Withdrawn NCT02974322 Phase 3 GED-0301;Placebo
15 Efficacy and Safety of GLPG0634 in Subjects With Active Crohn's Disease Completed NCT02048618 Phase 2 GLPG0634;Placebo
16 Fecal Microbiota Transplant (FMT) in Pediatric Active Crohn's Colitis Recruiting NCT02330211 Phase 1, Phase 2
17 Study to Evaluate the Testicular Safety of Filgotinib in Adult Males With Moderately to Severely Active Ulcerative Colitis Recruiting NCT03201445 Phase 2 Filgotinib;Placebo;Standard of Care
18 Efficacy and Safety Study of Apremilast to Treat Active Ulcerative Colitis Active, not recruiting NCT02289417 Phase 2 Apremilast;Placebo
19 Imuran Dosing in Crohn's Disease Study Terminated NCT00113503 Phase 2 Azathioprine weight-based dose;Azathioprine individualised dose
20 Study of Antibiotics in the Treatment of Colonic Crohn's Disease Terminated NCT00257699 Phase 2 Metronidazole placebo;ciprofloxacin placebo;ciprofloxacin;metronidazole
21 Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs Completed NCT01387594 Phase 1 lumbar puncture
22 Chromoendoscopy for Dysplasia Detection in Chronic Inflammatory Bowel Disease Unknown status NCT01505842 Not Applicable
23 Development of Niv Score of Capsule Endoscopy in Patients With Crohn's (CECDAIic) Unknown status NCT01793376
24 Surgical Decision Making Among People With Inflammatory Bowel Disease Completed NCT00438711
25 Efficacy of Infliximab as a Rescue Therapy in Pediatric Acute Severe Colitis Completed NCT02170714
26 Chromoendoscopy for Ulcerative Colitis Surveillance Completed NCT00274209
27 RCT: HDWL vs Virtual Chromoendoscopy in the Detection of Intraepithelial Neoplasia in Longstanding Colitis Recruiting NCT02822352 Not Applicable
28 Risk Factors for Colorectal Cancer in Patients With Inflammatory Bowel Disease Undergoing Surveillance: a Prospective Cohort Study Recruiting NCT01464151
29 A Longitudinal Study of Hermansky-Pudlak Syndrome Pulmonary Fibrosis Recruiting NCT02368340
30 Tailored Transition for IBD Adolescents Recruiting NCT02893670 Not Applicable
31 A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC) Recruiting NCT01848561
32 Post-Marketing Use Of Inflectra (Infliximab) For Standard Of Care Treatment Of Inflammatory Bowel Disease Active, not recruiting NCT02539368 Inflectra (infliximab)

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: crohn disease

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Genetic Tests for Crohn's Colitis

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Anatomical Context for Crohn's Colitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Colitis:

19
Colon Only

MalaCards organs/tissues related to Crohn's Colitis:

41
Colon, Skin, T Cells
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Publications for Crohn's Colitis

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Articles related to Crohn's Colitis:

(show top 50) (show all 70)
# Title Authors Year
1
New perspectives on the long-term outcome of segmental colectomy for Crohn's colitis: an observational study on 200 patients. ( 29511841 )
2018
2
Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis. ( 29023984 )
2018
3
IBD LIVE Case Series: Case 9: Do Race and Extraintestinal Manifestations Affect Treatment of Severe Crohn's Colitis? ( 29562279 )
2018
4
Segmental Resection versus Total Proctocolectomy for Crohn's Colitis: What is the Best Operation in the Setting of Medically Refractory Disease or Dysplasia? ( 29462390 )
2018
5
Letter: small bowel recurrence and fate of the rectum after total colectomy and ileostomy for Crohn's colitis. ( 28211630 )
2017
6
Completion Proctectomy for Crohn's Colitis: Lessons Learned. ( 28158506 )
2017
7
Plasma microRNA Profile Differentiates Crohn's Colitis From Ulcerative Colitis. ( 29272478 )
2017
8
Crohn's Colitis: Development of a multiplex gene expression assay comparing mRNA levels of susceptibility genes. ( 28365139 )
2017
9
Early histological findings may predict the clinical phenotype in Crohn's colitis. ( 28815033 )
2017
10
Colectomy in refractory Crohn's colitis improves nutrition and reduces steroid use. ( 28864042 )
2017
11
DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohn's Colitis: Implications for Surveillance. ( 27104828 )
2016
12
Colorectal cancer in Crohn's colitis is comparable to sporadic colorectal cancer. ( 27026089 )
2016
13
pANCA and ASCA in Children with IBD-Unclassified, Crohn's Colitis, and Ulcerative Colitis-A Longitudinal Report from the IBD Porto Group of ESPGHAN. ( 27135480 )
2016
14
Challenges in detection and real-time diagnosis of dysplasia in Crohn's colitis: the search still continues. ( 27102530 )
2016
15
Changes in biosimilar knowledge among European Crohn's Colitis Organization (ECCO) members : A updated survey. ( 27112706 )
2016
16
Listeria Rhombencephalitis Complicating Anti-TNF Treatment during an Acute Flare of Crohn's Colitis. ( 27651962 )
2016
17
Indolent T-cell lymphoproliferative disease of the gastro-intestinal tract following treatment with Adalimumab in resistant Crohn's colitis. ( 27402301 )
2016
18
Clinical recurrence and re-resection rates after extensive vs. segmental colectomy in Crohn's colitis: a retrospective cohort study. ( 26886936 )
2016
19
Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis. ( 26434930 )
2015
20
P621. Comparison between total abdominal colectomy and segmental colectomy in Crohn's colitis patients: Recurrence and re-resection rates. A retrospective cohort study. ( 25718123 )
2015
21
DOP047. Long Term Outcome of Segmental Resection for Crohn's Colitis: an Observational Study on 200 Patients. ( 25718260 )
2015
22
Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis. ( 26140094 )
2015
23
DOP045. pANCA and ASCA in > 400 children with IBD-unclassified (IBD-U), Crohn's Colitis and Ulcerative Colitis (UC) - a longitudinal report from the Porto pediatric IBD group of ESPGHAN. ( 25718257 )
2015
24
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
25
Colorectal polyps in ulcerative colitis and Crohn's colitis. ( 26446684 )
2015
26
Primary sclerosing cholangitis and the risk of colon neoplasia in patients with Crohn's colitis. ( 25725040 )
2015
27
Significance of the epithelioid granuloma in biopsies of Crohn's colitis. ( 25208107 )
2014
28
Detection rate and outcome of colonic serrated epithelial changes in patients with ulcerative colitis or Crohn's colitis. ( 24779703 )
2014
29
Subtotal colectomy in severe ulcerative and Crohn's colitis: what benefit does the laparoscopic approach confer? ( 25379999 )
2014
30
FOXP3+ regulatory T-cell counts correlate with histological response in Crohn's colitis treated with infliximab. ( 25354875 )
2014
31
Herpes simplex virus blepharitis in a patient with Crohn's colitis. ( 24613714 )
2014
32
Fecal microbiota transplantation inducing remission in Crohn's colitis and the associated changes in fecal microbial profile. ( 24667590 )
2014
33
A patient with severe Crohn's colitis responds to Faecal Microbiota Transplantation. ( 24239403 )
2014
34
Risk of permanent stoma in extensive Crohn's colitis: the impact of biological drugs. ( 23594132 )
2013
35
Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients. ( 22532293 )
2013
36
Case series: does a combination of anti-tnf antibodies and transient ileal fecal stream diversion in severe Crohn's colitis with perianal fistula prevent definitive stoma? ( 24091520 )
2013
37
Triptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis. ( 23643741 )
2013
38
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis. ( 23681475 )
2013
39
Early histological findings quantified by histomorphometry allow prediction of clinical phenotypes in Crohn's colitis patients. ( 23700718 )
2013
40
Colorectal cancer and Crohn's colitis: clinical implications from 313 surgical patients. ( 23381673 )
2013
41
About the colorectal cancer screening and surveillance in Crohn's colitis. ( 23478507 )
2013
42
High rates of metachronous colon cancer or dysplasia after segmental resection or subtotal colectomy in Crohn's colitis. ( 23669402 )
2013
43
Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. ( 23382084 )
2013
44
Lymphoid aggregates in Crohn's colitis and mucosal immunity. ( 23979405 )
2013
45
Intestinal microbiota transplantation: a case of Crohn's colitis with superimposed Clostridium difficile infection. ( 24831911 )
2013
46
An easy method to quantify plasma cells/plasma cell precursors in normal colonic mucosa, collagenous colitis and Crohn's colitis. ( 22993311 )
2012
47
Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy. ( 23265134 )
2012
48
Increased risk of colorectal cancer and dysplasia in patients with Crohn's colitis and primary sclerosing cholangitis. ( 21979184 )
2011
49
Crohn's colitis with perianal disease complicated by collagenous colitis: discourse on management options. ( 20090331 )
2010
50
Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis. ( 18255351 )
2008
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Variations for Crohn's Colitis

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Expression for Crohn's Colitis

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Search GEO for disease gene expression data for Crohn's Colitis.
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Pathways for Crohn's Colitis

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Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.91 CDH1 CXCL8 IFNG IL1B IL2 NOD2
2
ERK Signaling 64
Show member pathways
 13.74 CDH1 CDH3 CXCL8 IL1B IL2 NOS2
3
PEDF Induced Signaling 64
Show member pathways
 13.56 CXCL8 IFNG IL1B IL2 NOS2 TNF
4
Cytokine Signaling in Immune system 66
Show member pathways
 13.27 CXCL8 IFNG IL1B IL2 NOD2 NOS2
5
PAK Pathway 64
Show member pathways
 13.2 CDH1 CXCL8 IL1B IL2 TNF
6
Allograft rejection 1 37
Show member pathways
 12.83 CXCL8 IFNG IL1B IL2 TNF
7
Pathways in cancer 37
12.79 CDH1 CXCL8 IFNG IL2 NOS2
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.76 CXCL8 IFNG IL1B IL2 NOD2 NOS2
9
Influenza A 37
Show member pathways
 12.74 CXCL8 IFNG IL1B IL2 TNF
10
IL-2 Pathway 64
Show member pathways
 12.72 IFNG IL1B IL2 TNF
11
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.69 CXCL8 IFNG IL1B TNF
12
Regulation of IFNA signaling 66
Show member pathways
 12.58 CXCL8 IFNG IL1B IL2 TNF
13
Immune response IL-23 signaling pathway 22
Show member pathways
 12.55 IFNG IL1B IL2 NOS2 TNF
14
NF-kappaB Signaling 4
12.52 IFNG IL1B IL2 TNF
15
T cell receptor signaling pathway 37
Show member pathways
 12.4 IFNG IL1B IL2 TNF
16
Th17 cell differentiation 37
Show member pathways
 12.39 IFNG IL1B IL2 NOD2 TNF
17
Folate Metabolism 1
Show member pathways
 12.31 IFNG IL1B IL2 TNF
18
IL-17 Family Signaling Pathways 65
Show member pathways
 12.31 CXCL8 IFNG IL1B TNF
19
Th1 Differentiation Pathway 65
Show member pathways
 12.23 IFNG IL1B IL2 TNF
20
Toxoplasmosis 37
Show member pathways
 12.22 IFNG IL1B NOS2 TNF
21
IL-1 Family Signaling Pathways 65
Show member pathways
 12.19 CXCL8 IL1B NOS2 TNF
22
Toll Comparative Pathway 64
Show member pathways
 12.19 CXCL8 IFNG IL1B NOS2 TNF
23
Colorectal Cancer Metastasis 64
12.16 CDH1 IFNG NOS2 TNF
24
Tuberculosis 37
12.16 IFNG IL1B NOD2 NOS2 TNF
25
C-type lectin receptor signaling pathway 37
Show member pathways
 12.15 IL1B IL2 TNF
26
Necroptosis 37
Show member pathways
 12.14 IFNG IL1B TNF
27
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.11 CXCL8 IL1B TNF
28
Bacterial infections in CF airways 22
Show member pathways
 12.07 CXCL8 IFNG IL1B NOS2 TNF
29
Fluid shear stress and atherosclerosis 37
12.04 IFNG IL1B TNF
30
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.03 CDH1 CXCL8 IFNG IL1B IL2
31
Osteoclast differentiation 37
12 IFNG IL1B TNF
32
Interleukin-4 and 13 signaling 66
11.96 CXCL8 IL1B NOS2 TNF
33
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.95 IFNG IL2 TNF
34
IL12-mediated signaling events 1
Show member pathways
 11.95 IFNG IL1B IL2 NOS2
35
TNF signaling pathway 37
11.92 IL1B NOD2 TNF
36
Senescence and Autophagy in Cancer 1
11.91 CXCL8 IFNG IL1B
37
AGE-RAGE signaling pathway in diabetic complications 37
11.88 CXCL8 IL1B TNF
38
NF-kappa B signaling pathway 37
11.86 CXCL8 IL1B TNF
39
Rheumatoid arthritis 37
11.83 CXCL8 IFNG IL1B TNF
40
Glucocorticoid receptor regulatory network 1
11.79 CXCL8 IFNG IL2
41
Salmonella infection (KEGG) 37
11.79 CXCL8 IFNG IL1B NOS2
42
Innate Lymphoid Cell Differentiation Pathways 65
11.75 IFNG IL1B IL2 TNF
43
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.72 CXCL8 IFNG IL2 TNF
44
Pertussis 37
11.71 CXCL8 IL1B NOS2 TNF
45
Lung fibrosis 1
11.67 CXCL8 IL1B TNF
46
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.65 IFNG IL2 TNF
47
Amoebiasis 37
11.64 CXCL8 IFNG IL1B NOS2 TNF
48
ATF-2 transcription factor network 1
11.6 CXCL8 IFNG NOS2
49
Legionellosis 37
11.6 CXCL8 IL1B TNF
50
Photodynamic therapy-induced AP-1 survival signaling. 1
11.56 IFNG IL2 TNF
Sources

GO Terms for Crohn's Colitis

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Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 CDH1 CDH3 NOD2 TNF
2 extracellular space GO:0005615 9.43 CXCL8 IFNG IL1B IL2 SLIT2 TNF
3 extracellular region GO:0005576 9.17 CDH1 CXCL8 IFNG IL1B IL2 SLIT2
4 catenin complex GO:0016342 9.16 CDH1 CDH3

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 IFNG IL1B IL2 NOD2
2 positive regulation of gene expression GO:0010628 9.92 CDH3 IFNG IL1B TNF
3 immune response GO:0006955 9.92 CXCL8 IFNG IL1B IL2 TNF
4 regulation of signaling receptor activity GO:0010469 9.88 CXCL8 IFNG IL1B IL2 TNF
5 response to lipopolysaccharide GO:0032496 9.85 CXCL8 IL1B NOS2
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.84 IL1B NOD2 TNF
7 defense response GO:0006952 9.83 CXCL8 NOD2 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL1B NOD2 TNF
9 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL8 NOS2 TNF
10 activation of MAPK activity GO:0000187 9.8 IL1B NOD2 TNF
11 cellular response to organic cyclic compound GO:0071407 9.77 IL1B NOD2 TNF
12 inflammatory response GO:0006954 9.77 CXCL8 IL1B NOD2 NOS2 TNF
13 positive regulation of JNK cascade GO:0046330 9.76 IL1B NOD2 TNF
14 positive regulation of protein phosphorylation GO:0001934 9.76 IFNG IL1B IL2 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.72 IL1B NOD2 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 IL1B NOD2 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.69 IL1B IL2 TNF
18 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.68 IL1B IL2
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.68 IL1B TNF
20 protein import into nucleus, translocation GO:0000060 9.68 IFNG TNF
21 positive regulation of protein complex assembly GO:0031334 9.67 IFNG TNF
22 cell-cell adhesion mediated by cadherin GO:0044331 9.67 CDH1 CDH3
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IFNG IL1B TNF
24 positive regulation of osteoclast differentiation GO:0045672 9.66 IFNG TNF
25 embryonic digestive tract development GO:0048566 9.65 CXCL8 TNF
26 cytokine-mediated signaling pathway GO:0019221 9.65 CXCL8 IL1B IL2 NOS2 TNF
27 negative regulation of lipid catabolic process GO:0050995 9.64 IL1B TNF
28 regulation of regulatory T cell differentiation GO:0045589 9.63 IFNG IL2
29 positive regulation of interleukin-17 production GO:0032740 9.62 IL2 NOD2
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
32 regulation of establishment of endothelial barrier GO:1903140 9.6 IL1B TNF
33 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
34 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B NOD2 TNF
35 positive regulation of killing of cells of other organism GO:0051712 9.57 IFNG NOS2
36 sequestering of triglyceride GO:0030730 9.56 IL1B TNF
37 positive regulation of interleukin-8 production GO:0032757 9.5 IL1B NOD2 TNF
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 IFNG TNF
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.33 IFNG IL1B TNF
40 regulation of insulin secretion GO:0050796 9.26 IFNG IL1B NOS2 TNF
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IFNG IL1B IL2 TNF
Sources

Sources for Crohn's Colitis

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3 CDC
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9 Cosmic
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11 DGIdb
17 ExPASy
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