MCID: CRH005
MIFTS: 51

Crohn's Colitis

Categories: Gastrointestinal diseases
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Aliases & Classifications for Crohn's Colitis

MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis 11 14 16
Crohn Disease 43 71

Classifications:



External Ids:

Disease Ontology 11 DOID:0060192
ICD9CM 34 555.1
MeSH 43 D003424
NCIt 49 C37262
SNOMED-CT 68 7620006
ICD10 31 K50.1
UMLS 71 C0010346 C0156147

Summaries for Crohn's Colitis

Disease Ontology: 11 An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary: Crohn's Colitis, also known as crohn disease, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and ileocolitis, and has symptoms including diarrhea, skin lesions and rectal bleeding. An important gene associated with Crohn's Colitis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Immune response IL-23 signaling pathway. The drugs Mercaptopurine and Prucalopride have been mentioned in the context of this disorder. Affiliated tissues include colon only, bone marrow and colon, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Crohn's Colitis

Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1148)
# Related Disease Score Top Affiliating Genes
1 vitiligo-associated multiple autoimmune disease susceptibility 1 31.7 TNF IL17A CCR6
2 ileocolitis 31.0 TNF NOD2 ATG16L1
3 toxic megacolon 30.9 TNF CRP CCR6
4 intestinal tuberculosis 30.9 TNF NOD2 CRP
5 proctitis 30.7 TNF CRP CCR6
6 inflammatory bowel disease 5 30.6 NOD2 IRGM CCR6 ATG16L1
7 interstitial nephritis 30.6 TNF CRP CCR6
8 granulomatous dermatitis 30.6 TNF NOD2 CRP
9 pouchitis 30.5 TNF NOD2
10 serum amyloid a amyloidosis 30.4 TNF IL6 CRP
11 actinomycosis 30.4 TNF IL10 CRP
12 miliary tuberculosis 30.3 TNF IL10 CRP
13 amyloidosis 30.3 TNF IL6 IL1B CRP
14 hidradenitis suppurativa 30.2 TNF NOD2 IL1B IL17A CRP
15 takayasu arteritis 30.2 TNF IL6 IL10 CRP
16 hidradenitis 30.2 TNF NOD2 IL1B IL17A CRP
17 bowel dysfunction 30.2 TNF NOD2 IL6 IL1B IL10 CRP
18 granulomatosis with polyangiitis 30.2 TNF IL17A CRP CCR6
19 clostridium difficile colitis 30.2 IL1B CRP CCR6
20 blau syndrome 30.2 TNF NOD2 IL1B IL10
21 anogenital venereal wart 30.1 TNF IL6 CCR6
22 melkersson-rosenthal syndrome 30.1 TNF NOD2 CRP
23 gastrointestinal tuberculosis 30.1 TNF NOD2 CRP
24 abdominal tuberculosis 30.1 TNF NOD2 CRP
25 diverticulitis 30.1 TNF IL6 CRP CCR6
26 pyoderma gangrenosum 30.1 TNF NOD2 IL1B CCR6
27 lepromatous leprosy 30.0 TNF IL10 CCR6
28 autoimmune pancreatitis 30.0 IL10 CRP CCR6
29 retinal artery occlusion 30.0 IL6 IL10 CRP
30 pustulosis of palm and sole 30.0 TNF IL17A CRP CCR6
31 henoch-schoenlein purpura 30.0 TNF IL6 CRP CCR6
32 stomatitis 30.0 TNF IL6 IL1B IL10
33 relapsing polychondritis 30.0 TNF IL6 CRP
34 ischemic colitis 30.0 TNF IL6 CRP CCR6
35 intestinal perforation 30.0 TNF NOD2 IL6 IL10 CRP CCR6
36 lymph node tuberculosis 30.0 TNF CRP
37 nocardiosis 30.0 TNF CRP
38 pancreatitis 30.0 TNF IL6 IL1B IL10 CRP
39 intestinal obstruction 29.9 TNF NOD2 IL6 CRP
40 polyarteritis nodosa 29.9 TNF IL6 CRP
41 nutritional deficiency disease 29.9 IL6 CRP CCR6
42 conjunctivitis 29.9 TNF IL6 IL10
43 dacryoadenitis 29.9 IL17A IL10 CCR6
44 corneal ulcer 29.9 TNF IL6 IL1B
45 diarrhea 29.9 TNF NOD2 IL6 IL1B IL10
46 periostitis 29.9 TNF IL1B CRP
47 neutrophilic dermatosis, acute febrile 29.8 TNF IL1B IL17A CRP
48 inflammatory bowel disease 18 29.8 NOD2 IL17A IL10 CCR6 ATG16L1
49 pericardial effusion 29.8 TNF IL6 CRP
50 pleurisy 29.8 TNF IL1B CRP

Graphical network of the top 20 diseases related to Crohn's Colitis:



Diseases related to Crohn's Colitis

Symptoms & Phenotypes for Crohn's Colitis

Symptoms:

11
  • diarrhea
  • skin lesions
  • rectal bleeding
  • formation of ulcers

UMLS symptoms related to Crohn's Colitis:


nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 AQP8 ATG16L1 CCR6 CRP DEFB103A DEFB103B
2 immune system MP:0005387 9.8 ATG16L1 CCR6 CRP DEFB103A DEFB103B DEFB4A
3 hematopoietic system MP:0005397 9.44 ATG16L1 CCR6 DEFB103A DEFB103B DEFB4A IL10

Drugs & Therapeutics for Crohn's Colitis

Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 337)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mercaptopurine Approved Phase 4 50-44-2 667490
2
Prucalopride Approved Phase 4 179474-81-8 3052762
3
Ondansetron Approved, Withdrawn Phase 4 99614-02-5 4595
4
Azithromycin Approved Phase 4 83905-01-5 447043
5
Phylloquinone Approved, Investigational Phase 4 84-80-0 5284607
6
Esketamine Approved, Investigational Phase 4 33643-46-8 182137
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
8
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
9
Risedronic acid Approved, Investigational Phase 4 105462-24-6 5245
10
Golimumab Approved Phase 4 476181-74-5
11
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
12
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
13
Mesalazine Approved Phase 4 89-57-6 4075
14
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 4112 126941
15
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
16
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
17
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
18
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
19
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
20
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
21 Menaquinone Investigational Phase 4 1182-68-9
22 Hepcidins Phase 4
23 Serotonin Receptor Agonists Phase 4
24 Parenteral Nutrition Solutions Phase 4
25 Fat Emulsions, Intravenous Phase 4
26 Soybean oil, phospholipid emulsion Phase 4
27 Soy Bean Phase 4
28 Vaccines Phase 4
29 Chrysarobin Phase 4
30 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
31 Adrenergic beta-Agonists Phase 4
32 Adrenergic alpha-Agonists Phase 4
33 Adrenergic Agonists Phase 4
34 Adrenergic Agents Phase 4
35 Vasoconstrictor Agents Phase 4
36 Mydriatics Phase 4
37 Sympathomimetics Phase 4
38 Vitamin K Phase 4
39 Antifibrinolytic Agents Phase 4
40 Hemostatics Phase 4
41
Naphthoquinone Phase 4
42 Coagulants Phase 4
43 Antidepressive Agents Phase 4
44 Diphosphonates Phase 4
45 calcium channel blockers Phase 4
46 Vitamin K 1 Phase 4
47 Tin Fluorides Phase 4
48 Interleukin-12 Phase 4
49 Antineoplastic Agents, Hormonal Phase 4
50 Hormone Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 1420)
# Name Status NCT ID Phase Drugs
1 A Randomized, Controlled, Single-blind Study of Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
2 The Impact of Serum Vitamin D and Calcium Levels on the Body Composition, Bone Mineral Density, Muscle Strength, Exercise Tolerance, Fatigue and Inflammatory Activity in Patients With Crohn's Disease: a Randomized Controlled Trial Unknown status NCT02704624 Phase 4
3 Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China Unknown status NCT03901937 Phase 4 ω-3 polyunsaturated fatty acid
4 Can Vitamin D Supplementation in People With Crohn's Disease Improve Symptoms as an Adjunct Therapy? D-CODE Feasibility Randomised Controlled Trial Unknown status NCT03718182 Phase 4
5 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
6 The Effect of Prucalopride on Small Bowel Transit Time in Patients Undergoing Capsule Endoscopy: A Randomized Controlled Trial Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
7 Stricture Definition and Treatment (STRIDENT) Drug Therapy Study Unknown status NCT03220841 Phase 4 Adalimumab Injection;Thiopurine
8 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
9 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
10 Does Clinical Response Correlate With Serum Certolizumab Levels? A Prospective Open Label Trial of Adult Patients With Active Crohn's Disease (APOLLO) Unknown status NCT02597829 Phase 4 Certolizumab Pegol
11 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
12 Santeon InflixMab biosimILAr Research A Randomized, Controlled, Double Blind, Phase 4 Noninferiority Trial to Assess Efficacy of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission. Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
13 Optimizing Response in Crohn's Disease Patients Who Have Insufficient Initial Response or Who Have Loss of Successful Response to Certolizumab Pegol (Cimzia) Induction Therapy Unknown status NCT01024647 Phase 4
14 The Effect of Probiotics on Bowel Disease Unknown status NCT01078935 Phase 4
15 Double-blind Placebo Controlled Trial of VSL#3 in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
16 Phase IV Study Comparing a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
17 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation Unknown status NCT01765998 Phase 4 Probiotic;Placebo
18 Risk-stratified Randomized Controlled Trial in Paediatric Crohn Disease:Methotrexate vs Azathioprine or Adalimumab for Maintaining Remission in Patients at Low or High Risk for Aggressive Disease Course, respectively-a Treatment Strategy Unknown status NCT02852694 Phase 4 Methotrexate;Adalimumab;Azathioprine / 6 Mercaptopurine
19 Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients Completed NCT01180452 Phase 4
20 EUS Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
21 Ultra-proactive Therapeutic Drug Monitoring of Infliximab Based on Point-of-care-testing in Inflammatory Bowel Disease: a Pragmatic Trial Completed NCT04775732 Phase 4
22 An Open-Label, Phase 4 Study to Evaluate the Efficacy and Safety of Triple Combination Therapy With Vedolizumab IV, Adalimumab SC, and Oral Methotrexate in Early Treatment of Subjects With Crohn's Disease Stratified at Higher Risk for Developing Complications Completed NCT02764762 Phase 4 Vedolizumab;Adalimumab;Methotrexate
23 Influence of Immunosuppressive Treatment on Immunological Response to Pneumococcal Conjugated Vaccine (PCV13) in Patients With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
24 A Prospective Randomized Trial of Transversus Abdominis Plane (TAP) INtraoperative Block With Bupivacaine/Dexamethasone aGainst Liposomal Bupivacaine (Exparel®): the TINGLE Trial Completed NCT03723447 Phase 4 Liposomal bupivacaine;Bupivacaine/epinephrine/dexamethasone
25 Modulation of Immune Function by Parenteral Fish Oil in Patients With Crohn's Disease and High Inherent Tumor Necrosis Factor-alpha Production: a Randomized, Single Blinded, Cross-over Study Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
26 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission: A Multi-center, Double Blinded, Randomized, Placebo Controlled Study Completed NCT01817426 Phase 4 Infliximab
27 A Pilot Study to Evaluate the Applicability of the Crohn's Disease Endoscopy Index of Severity to Data Obtained by the Colonic Capsule Endoscopy in Ileocolonic Crohn's Disease Completed NCT01183845 Phase 4
28 Effects of Intraoperative Low-dose S-ketamine on Postoperative Mood and Pain in Patients With Crohn's Disease Undergoing Enterectomy With Mild to Moderate Depression: a Randomized Controlled Trial Completed NCT05506787 Phase 4 Esketamine;Placebo
29 Phase 4, Open Lable Non Randomized un Controlled Study. Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation Completed NCT02269358 Phase 4 METHOTREXATE
30 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease: a Placebo-controlled Randomized Trial Completed NCT02010762 Phase 4 Vitamin D;Placebo
31 Microarray Analysis of Peripheral Blood and Tissues of Patients With Immune Mediated Inflammatory Diseases Completed NCT00462072 Phase 4 Infliximab
32 A Cluster Randomized Controlled Trial of an Enhanced Treatment Algorithm for the Management of Crohn's Disease Completed NCT01698307 Phase 4
33 Rapidity of Onset of Response to Adalimumab in Luminal Crohn's Disease (RAPIDA Study) Completed NCT02148718 Phase 4
34 Effect of Early Prescription of Immunosuppressants on First Three-year Course of Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
35 Pediatric Crohn's Disease AdalImumab Level-based Optimization Treatment (PAILOT) Trial Completed NCT02256462 Phase 4 Adalimumab
36 A Randomized Double-Blind Phase 4 Study to Evaluate the Safety and Proportion of Subjects With Fistula Healing in 2 Dose Regimens of Entyvio (Vedolizumab IV) in the Treatment of Fistulizing Crohn's Disease (ENTERPRISE) Completed NCT02630966 Phase 4 Vedolizumab;Placebo
37 Treatment of Iron Deficiency Anaemia in Adults and Adolescents With Inflammatory Bowel Disease Using Ferrous Sulphate: Tolerance and Effects on Haemoglobin, Mood, Quality of Life and Fatigue Completed NCT01991314 Phase 4 Ferrous sulphate
38 Pneumococcal Vaccination of Crohn Patients - A Randomized, Non-blinded Phase 4 Clinical Trial With the Purpose of Investigating the Immune Response Against Two Different Pneumococcal Vaccines in Patients With Crohn's Disease Completed NCT01947010 Phase 4
39 The Ideal Management of Crohn's Disease: Top Down Versus Step Up Strategies. A Prospective Controlled Trial in the Benelux Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
40 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
41 An Open-Label, Multicenter and Open Enrollment Model, Postmarketing, Milk-Only Lactation Study to Assess Concentration of Vedolizumab in Breast Milk of Lactating Women With Active Ulcerative Colitis or Crohn's Disease Who Are Receiving Vedolizumab Therapeutically Completed NCT02559713 Phase 4 Vedolizumab
42 A RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP STUDY TO EVALUATE THE SAFETY AND EFFICACY OF SWITCHING FROM INNOVATOR INFLIXIMAB TO BIOSIMILAR INFLIXIMAB COMPARED WITH CONTINUED TREATMENT WITH INNOVATOR INFLIXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, PSORIATIC ARTHRITIS, ULCERATIVE COLITIS, CROHN'S DISEASE AND CHRONIC PLAQUE PSORIASIS THE NOR-SWITCH STUDY Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
43 A Randomized, Single Blinded, Controlled, Multi Center Phase 4 Study for Induction of Remission in Active Pediatric Crohn's Disease, Using 2 Months Antibiotic Course of Azithromycin Combined With Metronidazole vs. Metronidazole Alone. Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
44 The Influence of 5-Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
45 A Cluster Randomized Controlled Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
46 Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
47 Multicentre, Controlled, Randomised, Open, Cross-over Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tbl. 500 mg in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
48 A Phase III, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Antegren™ (Natalizumab) in Crohn's Disease Subjects Who Have Previously Participated in Antegren Crohn's Disease Studies Completed NCT00280956 Phase 4 natalizumab
49 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
50 The Effect of Vitamin K Supplementation on Bone Health Indices in Adult Crohn's Disease Completed NCT01235325 Phase 4

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


aminosalicylic acid
Azathioprine
Cholecalciferol
natalizumab
Opium
OPIUM ALKALOIDS HYDROCHLORIDE
OPIUM, POWDERED
paregoric
Thalidomide

Cochrane evidence based reviews: crohn disease

Genetic Tests for Crohn's Colitis

Anatomical Context for Crohn's Colitis

Organs/tissues related to Crohn's Colitis:

FMA: Colon Only
MalaCards : Bone Marrow, Colon, Bone, Placenta, Skin, Small Intestine, T Cells

Publications for Crohn's Colitis

Articles related to Crohn's Colitis:

(show top 50) (show all 898)
# Title Authors PMID Year
1
Image-Enhanced Endoscopy Surveillance of Colon and Pouch Dysplasia in IBD. 62
35867688 2022
2
Strongyloides colitis, a rare but important mimic of Crohn's disease, resulting in coma and multi-organ failure: a case report. 62
36447071 2022
3
State-of-the-art surgery for Crohn's disease: Part II-colonic Crohn's disease and associated neoplasms. 62
35729401 2022
4
Confocal laser endomicroscope with distal MEMS scanner for real-time histopathology. 62
36418439 2022
5
High-dose vitamin C therapy for symptomatic deficiency in a patient with myasthenia gravis and Crohn's disease. 62
34784069 2022
6
Use of complementary and alternative medicine (CAM) in patients with inflammatory bowel disease (IBD): results from a German nationwide survey of 2019 compared to a previous survey of 2002. 62
35722930 2022
7
Adalimumab therapy in pediatric Crohn's Disease: a two-year follow-up comparing 'top-down' and 'step-up' strategies. 62
36305799 2022
8
Correction: PLGA-microspheres-carried circGMCL1 protects against Crohn's colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy. 62
36123329 2022
9
PLGA-microspheres-carried circGMCL1 protects against Crohn's colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy. 62
36088391 2022
10
Remestemcel-L allogeneic bone marrow-derived mesenchymal stem cell product to treat medically refractory Crohn's colitis: preliminary phase IB/IIA study. 62
35714218 2022
11
Colorectal Strictures in Patients With Inflammatory Bowel Disease Do Not Independently Predict Colorectal Neoplasia. 62
34319381 2022
12
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview. 62
35629984 2022
13
Emphysematous cystitis as a potential marker of severe Crohn's disease. 62
35410166 2022
14
Acute Myopericarditis in the Setting of Crohn's Colitis: Challenging Management Decisions. 62
35399407 2022
15
Small Bowel Crohn's Disease Recurrence is Common After Total Proctocolectomy for Crohn's Colitis. 62
34759246 2022
16
Acute myocarditis revealing autoimmune and inflammatory disorders: Clinical presentation and outcome. 62
34979146 2022
17
Crohn's Disease Diagnosed in a Man with Sarcoidosis: Coincidence or Correspondence? 62
35669381 2022
18
Colour me blue: chromoendoscopy and advanced detection methods in ulcerative colitis. 62
34871195 2022
19
5-Aminosalicylic Acid Chemoprevention in Inflammatory Bowel Diseases: Is It Necessary in the Age of Biologics and Small Molecules? 62
35224015 2022
20
Validation of the Padova Prognostic Score for Colitis in Predicting Long-Term Outcome After Restorative Proctocolectomy. 62
35959125 2022
21
Isolated Crohn's Colitis: Is Localization Crucial? Characteristics of Pediatric Patients From the CEDATA-GPGE Registry. 62
35712614 2022
22
Stem Cell Therapy for the Treatment of Crohn's Disease; Current Obstacles and Future Hopes. 62
34514993 2022
23
SULT1A1 and SULT1A2 Associated Extensive Prolapse-Type Inflammatory Polyposis in Crohn's Colitis. 62
34921041 2021
24
Potassium bromate (KBrO3) modulates oxidative stress and inflammatory biomarkers in sodium hydroxide (NaOH) - induced Crohn's colitis in Wistar rats. 62
33848442 2021
25
Total Transperineal Laparoscopic Proctectomy for the Treatment of Crohn's Proctitis. 62
34285146 2021
26
Role of Extended Mesenteric Excision in Postoperative Recurrence of Crohn's Colitis: A Single-Center Study. 62
34597277 2021
27
The long-term incidence of dysplasia and colorectal cancer in a Crohn's colitis population-based cohort. 62
34041848 2021
28
Assessing effectiveness and patient perceptions of a novel electronic medical record for the management of inflammatory bowel disease. 62
34584976 2021
29
Multicentre randomised controlled trial on virtual chromoendoscopy in the detection of neoplasia during colitis surveillance high-definition colonoscopy (the VIRTUOSO trial). 62
33214162 2021
30
Continent ileostomy: short- and long-term outcomes of a forgotten procedure. 62
34686880 2021
31
Severity of complications following restorative proctocolectomy in children is related to staging not diagnosis. 62
32972742 2021
32
Molecular characterization of ulcerative colitis-associated colorectal carcinomas. 62
33318582 2021
33
Atypical case of Crohn's colitis in a patient with adult-onset Still's disease. 62
34130968 2021
34
Long term remission after ileorectal anastomosis in Crohn's colitis. 62
32616463 2021
35
Transperineal total mesorectal excision for rectal cancer on the residual rectum after multiple abdominal surgeries in a patient with Crohn's disease: a case report. 62
33983535 2021
36
Initial experience with transanal proctectomy in children. 62
33358416 2021
37
Chylomicrons-Simulating Sustained Drug Release in Mesenteric Lymphatics for the Treatment of Crohn's-Like Colitis. 62
32978613 2021
38
Perceptive eating as part of the journey in inflammatory bowel disease: Lessons learned from lived experience. 62
33487280 2021
39
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. 62
33690604 2021
40
Colorectal cancer in Crohn's colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study. 62
32918621 2021
41
Colonic Crohn's disease - decision is more important than incision: A surgical dilemma. 62
33552390 2021
42
The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis. 62
32967429 2020
43
Crohn's Colitis Care (CCCare): bespoke cloud-based clinical management software for inflammatory bowel disease. 62
33161791 2020
44
Kayexalate-induced colitis and rectal stricture. 62
33318260 2020
45
Efficacy of biosimilar infliximab CT-P13 among inpatients with severe steroid-refractory colitis. 62
32710391 2020
46
High-Definition Chromoendoscopy Superior to High-Definition White-Light Endoscopy in Surveillance of Inflammatory Bowel Diseases in a Randomized Trial. 62
32353535 2020
47
Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications. 62
32236745 2020
48
Recurrent pericarditis in an adolescent with Crohn's colitis. 62
32863666 2020
49
Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis. 62
32706073 2020
50
Laparoscopic total proctocolectomy for Crohn's colitis - a video vignette. 62
31970846 2020

Variations for Crohn's Colitis

Expression for Crohn's Colitis

Search GEO for disease gene expression data for Crohn's Colitis.

Pathways for Crohn's Colitis

Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 TNF NOD2 IL6 IL1B IL17A IL10
2
Show member pathways
12.53 TNF IL6 IL1B IL17A IL10
3
Show member pathways
12.45 TNF NOD2 IL6 IL1B
4
Show member pathways
12.35 TNF IL6 IL1B DEFB4A
5
Show member pathways
12.26 DEFB4A DEFB103B DEFB103A DEFA5 CCR6
6 12.11 TNF IL6 IL1B IL10
7 12.05 TNF IL6 IL1B IL10
8 11.86 IL10 IL17A IL1B IL6 TNF
9 11.85 TNF IL1B IL17A IL10
10
Show member pathways
11.8 IL6 IL1B IL17A
11
Show member pathways
11.77 TNF IL6 IL1B IL17A IL10
12 11.71 TNF IL6 IL1B IL10
13 11.7 TNF IL6 IL1B
14 11.68 TNF IL6 IL10 CRP
15 11.66 IL6 IL1B IL17A
16
Show member pathways
11.61 TNF IL6 IL1B
17 11.61 TNF IL6 IL1B
18 11.6 TNF IL6 IL10
19 11.6 TNF IL6 IL1B IL10
20
Show member pathways
11.57 TNF NOD2 IL6 IL10
21 11.49 TNF NOD2 IL6 DEFB4A
22 11.45 IL1B IL6 TNF
23 11.43 TNF IL6 IL1B IL10
24 11.25 TNF IL6 IL1B IL10
25 11.24 TNF IL6 IL1B
26 11.13 TNF IL6 IL1B IL17A
27 11.07 IL10 IL1B IL6
28 11.02 TNF IL6 IL1B IL10
29 11.01 TNF IL6 CRP
30 10.96 TNF IL6 IL1B IL17A IL10
31 10.92 TNF IL1B IL17A IL10 CCR6
32 10.9 TNF IL6 IL1B IL17A
33 10.74 IL6 IL1B
34 10.69 TNF IL6 IL17A IL10
35
Show member pathways
10.32 TNF IL6

GO Terms for Crohn's Colitis

Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.23 DEFB4A DEFB103B DEFB103A DEFA5

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.39 CRP IL17A IL1B IL6 IRGM TNF
2 immune response GO:0006955 10.3 TNF IL6 IL1B IL17A IL10 DEFB4A
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.24 IL10 IL1B IL6 TNF
4 cell chemotaxis GO:0060326 10.19 DEFB4A DEFB103B DEFB103A CCR6
5 positive regulation of interleukin-6 production GO:0032755 10.16 IL17A IL1B IL6 NOD2 TNF
6 regulation of insulin secretion GO:0050796 10.15 TNF IL6 IL1B
7 positive regulation of interleukin-1 beta production GO:0032731 10.15 TNF NOD2 IL6 IL17A
8 response to activity GO:0014823 10.14 TNF IL6 IL10
9 positive chemotaxis GO:0050918 10.13 DEFB4A DEFB103B DEFB103A
10 cellular response to lipopolysaccharide GO:0071222 10.13 DEFA5 IL10 IL1B IL6 IRGM NOD2
11 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.11 TNF IL6 IL10
12 defense response to fungus GO:0050832 10.11 IL17A DEFB4A DEFA5
13 defense response to bacterium GO:0042742 10.1 TNF NOD2 IRGM IL10 DEFB4A DEFB103B
14 liver regeneration GO:0097421 10.08 TNF IL6 IL10
15 killing of cells of another organism GO:0031640 10.08 DEFB4A DEFB103B DEFB103A DEFA5
16 negative regulation of neurogenesis GO:0050768 10.07 TNF IL6 IL1B
17 positive regulation of interleukin-8 production GO:0032757 10.07 TNF NOD2 IL6 IL1B DEFA5
18 positive regulation of chemokine production GO:0032722 10.06 TNF IL6 IL1B
19 positive regulation of glial cell proliferation GO:0060252 10.04 TNF IL6 IL1B
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.01 IL10 IL1B TNF
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.01 TNF NOD2 IL6 IL17A
22 positive regulation of neuroinflammatory response GO:0150078 10 TNF IL6 IL1B
23 killing by host of symbiont cells GO:0051873 9.99 DEFB103B DEFB103A DEFA5
24 negative regulation of lipid storage GO:0010888 9.97 TNF IL6 CRP
25 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.96 TNF NOD2
26 negative regulation of cytokine production involved in immune response GO:0002719 9.95 TNF IL10
27 positive regulation of fever generation GO:0031622 9.95 TNF IL1B
28 protein lipidation involved in autophagosome assembly GO:0061739 9.93 IRGM ATG16L1
29 negative regulation of interleukin-18 production GO:0032701 9.92 NOD2 IL10
30 sequestering of triglyceride GO:0030730 9.92 TNF IL1B
31 vascular endothelial growth factor production GO:0010573 9.91 TNF IL6 IL1B
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.9 TNF IL1B
33 chronic inflammatory response to antigenic stimulus GO:0002439 9.88 IL10 TNF
34 defense response GO:0006952 9.81 TNF NOD2 IRGM DEFB4A DEFB103B DEFB103A
35 defense response to Gram-negative bacterium GO:0050829 9.8 DEFA5 DEFB103A DEFB103B DEFB4A IL17A IL6
36 defense response to Gram-positive bacterium GO:0050830 9.6 TNF NOD2 IL6 IL1B IL17A DEFB4A

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 TNF IL6 IL1B IL17A IL10
2 chemoattractant activity GO:0042056 9.63 DEFB4A DEFB103B DEFB103A
3 CCR6 chemokine receptor binding GO:0031731 9.1 DEFB4A DEFB103B DEFB103A

Sources for Crohn's Colitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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