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MCID: CRH005
MIFTS: 61

Crohn's Colitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Crohn's Colitis

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MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis 12 15 17
Crohn Disease 45 74

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0060192
ICD9CM 36 555.1
MeSH 45 D003424
SNOMED-CT 69 50440006 7620006
ICD10 34 K50.1
Sources

Summaries for Crohn's Colitis

About this section
Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary : Crohn's Colitis, also known as crohn disease, is related to jejunoileitis and ileocolitis, and has symptoms including diarrhea, rectal bleeding and skin lesions. An important gene associated with Crohn's Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Infliximab and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Crohn's Colitis

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Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 456)
# Related Disease Score Top Affiliating Genes
1 jejunoileitis 31.0 IL1B TNF
2 ileocolitis 30.5 NOD2 TNF
3 pyoderma gangrenosum 30.5 CXCL8 NOD2 TNF
4 pyoderma 30.5 CXCL8 NOD2 TNF
5 spondylarthropathy 30.4 NOD2 TNF
6 vaginitis 30.2 CXCL8 IL1B
7 cytomegalovirus infection 30.2 CXCL8 IL1B TNF
8 blau syndrome 30.2 IL1B NOD2 TNF
9 familial mediterranean fever 30.0 IL1B NOD2 TNF
10 lung disease 29.9 CXCL8 IL1B TNF
11 acute respiratory distress syndrome 29.8 CXCL8 IL1B TNF
12 pyelonephritis 29.8 CXCL8 IL1B TNF
13 appendicitis 29.8 CXCL8 IL1B TNF
14 pneumonia 29.8 CXCL8 IL1B TNF
15 arthritis 29.8 CXCL8 IFNG IL1B NOD2 TNF
16 periodontal disease 29.8 CXCL8 IL1B TNF
17 necrotizing fasciitis 29.8 CXCL8 IL2
18 colitis 29.8 CXCL8 IFNG IL1B IL2 NOD2 NOS2
19 psoriatic arthritis 29.7 IL1B NOD2 TNF
20 gastritis 29.7 CXCL8 IL1B NOS2
21 central nervous system vasculitis 29.7 IFNG IL1B TNF
22 miliary tuberculosis 29.7 IFNG TNF
23 neuritis 29.7 IFNG IL1B TNF
24 osteomyelitis 29.6 CXCL8 IFNG IL1B TNF
25 monocytic leukemia 29.6 CXCL8 IFNG IL1B TNF
26 dengue hemorrhagic fever 29.6 CXCL8 IFNG TNF
27 ulcerative colitis 29.6 CXCL8 IFNG IL1B IL2 NOD2 TNF
28 spinal cord injury 29.5 CXCL8 NOS2 TNF
29 hematopoietic stem cell transplantation 29.5 IFNG IL2 TNF
30 meningitis 29.4 CXCL8 IFNG IL1B TNF
31 inflammatory bowel disease 29.4 CXCL8 IFNG IL1B IL2 NOD2 TNF
32 pulmonary sarcoidosis 29.2 IFNG IL2 TNF
33 sarcoidosis 1 29.1 IFNG IL1B IL2 NOD2 TNF
34 rheumatoid arthritis 29.0 CXCL8 IFNG IL1B IL2 TNF
35 pleurisy 29.0 CXCL8 IFNG IL2 TNF
36 intestinal disease 28.5 CDH1 CXCL8 IL1B IL2 NOD2 TNF
37 inflammatory bowel disease 1 12.2
38 inflammatory bowel disease 10 11.4
39 inflammatory bowel disease 17 11.4
40 thiopurines, poor metabolism of, 1 11.3
41 inflammatory bowel disease 29 11.2
42 inflammatory bowel disease 13 11.1
43 inflammatory bowel disease 14 11.1
44 inflammatory bowel disease 19 11.1
45 inflammatory bowel disease 25, autosomal recessive 11.1
46 inflammatory bowel disease 28, autosomal recessive 11.1
47 bile acid malabsorption, primary 11.0
48 autoimmune disease 6 11.0
49 short bowel syndrome 11.0
50 vaginal disease 10.4 CXCL8 IL1B

Graphical network of the top 20 diseases related to Crohn's Colitis:



Diseases related to Crohn's Colitis
Sources

Symptoms & Phenotypes for Crohn's Colitis

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Symptoms:

12
  • • diarrhea
  • • rectal bleeding
  • • skin lesions
  • • formation of ulcers

UMLS symptoms related to Crohn's Colitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Crohn's Colitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 IL1B IL2 NOD2 NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 IL1B IL2 NOD2 NOS2 TNF

MGI Mouse Phenotypes related to Crohn's Colitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 CDH1 IFNG IL1B IL2 NOS2 SLIT2
2 digestive/alimentary MP:0005381 9.95 CDH1 IFNG IL2 NOD2 NOS2 SLIT2
3 growth/size/body region MP:0005378 9.92 CDH1 IFNG IL1B IL2 NOD2 NOS2
4 endocrine/exocrine gland MP:0005379 9.91 CDH1 CDH3 IFNG IL2 NOS2 SLIT2
5 immune system MP:0005387 9.8 CDH1 IFNG IL1B IL2 NOD2 NOS2
6 integument MP:0010771 9.7 CDH1 CDH3 IFNG IL1B NOS2 SLIT2
7 mortality/aging MP:0010768 9.56 CDH1 IFNG IL1B IL2 NOD2 NOS2
8 neoplasm MP:0002006 9.1 CDH1 IFNG IL1B IL2 NOS2 TNF
Sources

Drugs & Therapeutics for Crohn's Colitis

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Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 470)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
2
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
3
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
5
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
6
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
7
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
8
Rifabutin Approved, Investigational Phase 4,Phase 3 72559-06-9 46783538 6323490
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
10
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
11
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
12
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
13
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
14
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7439-89-6, 15438-31-0 27284 23925
15
Prucalopride Approved Phase 4 179474-81-8
16
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
17
Mercaptopurine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-44-2 667490
18
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
19
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
21
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 51-43-4 5816
22
Racepinephrine Approved Phase 4,Phase 2,Not Applicable 329-65-7 838
23
Azithromycin Approved Phase 4 83905-01-5 447043 55185
24
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 5281004 63006
25
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
26 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 943609-66-3
27
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
28
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
29
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
30
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
31 Menaquinone Approved, Investigational Phase 4,Phase 1 1182-68-9
32
Phylloquinone Approved, Investigational Phase 4,Phase 1 84-80-0
33
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
34
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
35
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
36
Bupivacaine Approved, Investigational Phase 4,Not Applicable 38396-39-3, 2180-92-9 2474
37
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
38
Ustekinumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 815610-63-0
39
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
40
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
41
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 5284616 6436030
42
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 93-14-1 3516
43
Losartan Approved Phase 4 114798-26-4 3961
44
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
45
Dextromethorphan Approved Phase 4,Phase 1 125-71-3 5362449 5360696
46
Caffeine Approved Phase 4,Phase 1 58-08-2 2519
47
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 1177-87-3
48
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 50-02-2 5743
49
Vancomycin Approved Phase 4,Phase 2 1404-90-6 14969 441141
50
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 564-25-0 54671203

Interventional clinical trials:

(show top 50) (show all 1336)
# Name Status NCT ID Phase Drugs
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
5 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
6 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
7 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
8 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
9 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
12 Does Clinical Response Correlate With Serum Certolizumab Levels? Unknown status NCT02597829 Phase 4 Certolizumab Pegol
13 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
14 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
15 Brief Escalation of Adalimumab Treatment for Prevention of Clinical Relapse in IBD Unknown status NCT03059849 Phase 4 Adalimumab
16 Anemia in Inflammatory Bowel Disease Unknown status NCT02760940 Phase 4 oral liposomal iron
17 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
18 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
19 Prucalopride Prior to Small Bowel Capsule Endoscopy Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
20 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
21 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
22 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
23 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
24 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
25 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
26 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
27 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
28 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
29 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
30 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
31 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
32 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
33 Pediatric Crohn's Disease AdalImumab Level-based Optimization Treatment (PAILOT) Trial Completed NCT02256462 Phase 4 Adalimumab
34 Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease Completed NCT02630966 Phase 4 Vedolizumab;Placebo
35 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
36 Vitamin D Supplementation in Adult Crohn's Disease Completed NCT01369667 Phase 4
37 Adalimumab-psoriasis and Small Bowel Lesions Completed NCT01556672 Phase 4 Adalimumab
38 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4 risedronate;placebo
39 Early Immunosuppressants in Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
40 Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Completed NCT00280956 Phase 4 natalizumab
41 Postmarketing Vedolizumab Milk-Only Lactation Study in Lactating Women With Active Ulcerative Colitis or Crohn's Disease Completed NCT02559713 Phase 4 Vedolizumab
42 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
43 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
44 The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Completed NCT01235325 Phase 4
45 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
46 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
47 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
48 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
49 Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation Completed NCT02269358 Phase 4 METHOTREXATE
50 Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: crohn disease

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Genetic Tests for Crohn's Colitis

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Anatomical Context for Crohn's Colitis

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MalaCards organs/tissues related to Crohn's Colitis:

42
Colon, Bone, Skin, T Cells, Testes, Lung, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Colitis:

20
Colon Only
Sources

Publications for Crohn's Colitis

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Articles related to Crohn's Colitis:

(show top 50) (show all 1415)
# Title Authors Year
1
The Cost of Inflammatory Bowel Disease: An Initiative From the Crohn's & Colitis Foundation. ( 31112238 )
2019
2
The missing "C": Crohn's, colitis and coping. ( 31062719 )
2019
3
Backwash ileitis in ulcerative colitis: Are there MR enterographic features that distinguish it from Crohn disease? ( 30599862 )
2019
4
Enteric Virome and Bacterial Microbiota in Children With Ulcerative Colitis and Crohn Disease. ( 30169455 )
2019
5
Pediatric Inflammatory Bowel Disease Clinical Innovations Meeting of the Crohn's & Colitis Foundation: Charting the Future of Pediatric IBD. ( 29931102 )
2019
6
Iatrogenic Kaposi sarcoma of the terminal ileum following short-term treatment with immunomodulators for Crohn disease: A case report. ( 31096523 )
2019
7
Crohn disease complicated by IgA vasculitis during therapy with tumor necrosis factor-α inhibitor. ( 30733426 )
2019
8
Inter-radiologist agreement using Society of Abdominal Radiology-American Gastroenterological Association (SAR-AGA) consensus nomenclature for reporting CT and MR enterography in children and young adults with small bowel Crohn disease. ( 30120514 )
2019
9
Early Predictors of the Long-term Response to Therapy in Patients With Crohn Disease Derived From a Time-Intensity Curve Analysis After Microbubble Contrast Agent Injection. ( 30208230 )
2019
10
Crohn Disease: A 5-Point MR Enterocolonography Classification Using Enteroscopic Findings. ( 30422709 )
2019
11
The Clinical Significance of Crohn Disease Activity at Resection Margins. ( 30444436 )
2019
12
Effectiveness and Safety of Reference Infliximab and Biosimilar in Crohn Disease: A French Equivalence Study. ( 30534946 )
2019
13
Comparison of MRI Activity Scoring Systems and Features for the Terminal Ileum in Patients With Crohn Disease. ( 30540212 )
2019
14
Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease. ( 30604884 )
2019
15
Anti-interleukin 12/23 in the treatment of erythema nodosum and Crohn disease: A case report. ( 30620119 )
2019
16
Enterourachal Fistula as an Initial Presentation in Crohn Disease. ( 30671379 )
2019
17
Long-term Results of the Side-to-side Isoperistaltic Strictureplasty in Crohn Disease: 25-year Follow-up and Outcomes. ( 30720502 )
2019
18
Comparison of three oral contrast preparations for magnetic resonance enterography in pediatric patients with known or suspected Crohn disease: a prospective randomized trial. ( 30852650 )
2019
19
Is Crohn Disease the price to pay today for having survived to the Black Death? ( 30893422 )
2019
20
Usefulness of Strain Elastography, ARFI Imaging, and Point Shear Wave Elastography for the Assessment of Crohn Disease Strictures. ( 30920016 )
2019
21
Diagnosis and Management of Crohn Disease. ( 30969326 )
2019
22
Traditional Chinese medicine for management of recurrent and refractory Crohn disease: A case report. ( 30985690 )
2019
23
Influence of previous corticosteroid treatment on the efficacy and safety of infliximab therapy in Crohn disease. ( 30985712 )
2019
24
Medicinal Sulphur Polypore Mushroom Laetiporus sulphureus (Agaricomycetes) Plus Tiny Amounts of Essential Oils Decrease the Activity of Crohn Disease. ( 31002610 )
2019
25
Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry. ( 31006801 )
2019
26
Development of an Objective Model to Define Near-Term Risk of Ileocecal Resection in Patients with Terminal Ileal Crohn Disease. ( 31050733 )
2019
27
Development and Validation of Machine Learning Models in Prediction of Remission in Patients With Moderate to Severe Crohn Disease. ( 31074823 )
2019
28
Acute myopericarditis in a patient recently started on mesalazine for Crohn disease. ( 31083809 )
2019
29
Anorexia Nervosa Complicating Pediatric Crohn Disease-Case Report and Literature Review. ( 30356737 )
2018
30
Aortitis With an Aneurysm at Initial Presentation of Crohn Disease. ( 29927874 )
2018
31
Association of Blepharitis and Ectropion With Tumor Necrosis Factor α Inhibitor Treatment in Crohn Disease. ( 30419086 )
2018
32
Chronic Recurrent Multifocal Osteomyelitis in Crohn Disease: Complete Resolution With Anti-TNFα Therapy. ( 27050047 )
2018
33
The Crohn's & Colitis Australia Inflammatory Bowel Disease Audit: Measuring the quality of care in Australia. ( 30525299 )
2018
34
Crohn's & Colitis Foundation Engaging IBD Patients for 50 Years. ( 29688467 )
2018
35
IBD LIVE Case Series: Case 9: Do Race and Extraintestinal Manifestations Affect Treatment of Severe Crohn's Colitis? ( 29562279 )
2018
36
Segmental Resection versus Total Proctocolectomy for Crohn's Colitis: What is the Best Operation in the Setting of Medically Refractory Disease or Dysplasia? ( 29462390 )
2018
37
New perspectives on the long-term outcome of segmental colectomy for Crohn's colitis: an observational study on 200 patients. ( 29511841 )
2018
38
Histological features of ileitis differentiating pediatric Crohn disease from ulcerative colitis with backwash ileitis. ( 29089273 )
2018
39
Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis. ( 29023984 )
2018
40
Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index. ( 30083065 )
2018
41
Anti-NMDAR encephalitis in a patient with Crohn disease receiving adalimumab. ( 29988714 )
2018
42
Nonbacterial Thrombotic Endocarditis Associated With Crohn Disease. ( 29305852 )
2018
43
Familial Mediterranean fever mimicking Crohn disease: A case report. ( 29505533 )
2018
44
Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa: A Population-Based Analysis in the United States. ( 29800049 )
2018
45
Interstitial Nephritis Secondary to Vedolizumab Treatment in Crohn Disease and Safe Rechallenge Using Steroids: A Case Report. ( 29162338 )
2018
46
Metastatic vulvovaginal Crohn disease in the setting of well-controlled intestinal disease. ( 30235375 )
2018
47
Differentiation Between Crohn Disease and Intestinal Tuberculosis in Children. ( 28489674 )
2018
48
A RARE CASE OF CROHN DISEASE COMPLICATED WITH STEROID MONOTHERAPY-RELATED RETROPHARYNGEAL ABSCESS AND INITIALLY MISINTERPRETED PYODERMA GANGRENOSUM DEVELOPMENT. ( 30063691 )
2018
49
Detection of Crohn Disease in Patients with Spondyloarthropathy: The SpACE Capsule Study. ( 29449505 )
2018
50
Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease. ( 29881302 )
2018
Sources

Variations for Crohn's Colitis

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Expression for Crohn's Colitis

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Search GEO for disease gene expression data for Crohn's Colitis.
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Pathways for Crohn's Colitis

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Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.91 CDH1 CXCL8 IFNG IL1B IL2 NOD2
2
ERK Signaling 65
Show member pathways
 13.74 CDH1 CDH3 CXCL8 IL1B IL2 NOS2
3
PEDF Induced Signaling 65
Show member pathways
 13.57 CXCL8 IFNG IL1B IL2 NOS2 TNF
4
TGF-Beta Pathway 65
Show member pathways
 13.44 CDH1 CXCL8 IFNG IL1B IL2 TNF
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.27 CXCL8 IFNG IL1B IL2 NOD2 NOS2
6
PAK Pathway 65
Show member pathways
 13.2 CDH1 CXCL8 IL1B IL2 TNF
7
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 12.88 CXCL8 IFNG IL1B IL2 NOD2 NOS2
8
Allograft rejection 38 1
Show member pathways
 12.84 CXCL8 IFNG IL1B IL2 TNF
9
Pathways in cancer 38
12.79 CDH1 CXCL8 IFNG IL2 NOS2
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.7 CXCL8 IFNG IL1B TNF
11
Th17 cell differentiation 38
Show member pathways
 12.56 IFNG IL1B IL2 NOD2 TNF
12
Immune response IL-23 signaling pathway 23
Show member pathways
 12.55 IFNG IL1B IL2 NOS2 TNF
13
T cell receptor signaling pathway 38
Show member pathways
 12.54 IFNG IL1B IL2 TNF
14
NF-kappaB Signaling 4
12.52 IFNG IL1B IL2 TNF
15
Selenium Micronutrient Network 1
Show member pathways
 12.32 IFNG IL1B IL2 TNF
16
IL-17 Family Signaling Pathways 66
Show member pathways
 12.32 CXCL8 IFNG IL1B TNF
17
Toll Comparative Pathway 65
Show member pathways
 12.26 CXCL8 IFNG IL1B NOS2 TNF
18
Toxoplasmosis 38
Show member pathways
 12.24 IFNG IL1B NOS2 TNF
19
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.23 CXCL8 IFNG IL1B IL2 TNF
20
IL-1 Family Signaling Pathways 66
Show member pathways
 12.21 CXCL8 IL1B NOS2 TNF
21
Colorectal Cancer Metastasis 65
12.17 CDH1 IFNG NOS2 TNF
22
Tuberculosis 38
12.16 IFNG IL1B NOD2 NOS2 TNF
23
C-type lectin receptor signaling pathway 38
Show member pathways
 12.15 IL1B IL2 TNF
24
Necroptosis 38
Show member pathways
 12.15 IFNG IL1B TNF
25
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.12 CXCL8 IL1B TNF
26
Bacterial infections in CF airways 23
Show member pathways
 12.09 CXCL8 IFNG IL1B NOS2 TNF
27
Fluid shear stress and atherosclerosis 38
12.05 IFNG IL1B TNF
28
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.05 CDH1 CXCL8 IFNG IL1B IL2
29
Th1 Differentiation Pathway 66
Show member pathways
 12.05 IFNG IL1B IL2 TNF
30
Osteoclast differentiation 38
12 IFNG IL1B TNF
31
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12 IFNG IL1B TNF
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.96 IFNG IL2 TNF
33
Interleukin-4 and 13 signaling 67
11.96 CXCL8 IL1B NOS2 TNF
34
IL12-mediated signaling events 1
Show member pathways
 11.95 IFNG IL1B IL2 NOS2
35
TNF signaling pathway 38
11.93 IL1B NOD2 TNF
36
Senescence and Autophagy in Cancer 1
11.91 CXCL8 IFNG IL1B
37
AGE-RAGE signaling pathway in diabetic complications 38
11.89 CXCL8 IL1B TNF
38
NF-kappa B signaling pathway 38
11.88 CXCL8 IL1B TNF
39
Rheumatoid arthritis 38
11.84 CXCL8 IFNG IL1B TNF
40
Salmonella infection (KEGG) 38
11.81 CXCL8 IFNG IL1B NOS2
41
Glucocorticoid receptor regulatory network 1
11.79 CXCL8 IFNG IL2
42
Innate Lymphoid Cell Differentiation Pathways 66
11.76 IFNG IL1B IL2 TNF
43
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.72 CXCL8 IFNG IL2 TNF
44
Pertussis 38
11.71 CXCL8 IL1B NOS2 TNF
45
Amoebiasis 38
11.7 CXCL8 IFNG IL1B NOS2 TNF
46
Lung fibrosis 1
11.67 CXCL8 IL1B TNF
47
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.65 IFNG IL2 TNF
48
ATF-2 transcription factor network 1
11.61 CXCL8 IFNG NOS2
49
Legionellosis 38
11.6 CXCL8 IL1B TNF
50
Photodynamic therapy-induced AP-1 survival signaling. 1
11.56 IFNG IL2 TNF
Sources

GO Terms for Crohn's Colitis

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Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 CDH1 CDH3 NOD2 TNF
2 extracellular space GO:0005615 9.43 CXCL8 IFNG IL1B IL2 SLIT2 TNF
3 extracellular region GO:0005576 9.17 CDH1 CXCL8 IFNG IL1B IL2 SLIT2
4 catenin complex GO:0016342 9.16 CDH1 CDH3

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 IFNG IL1B IL2 NOD2
2 positive regulation of gene expression GO:0010628 9.93 CDH3 IFNG IL1B TNF
3 immune response GO:0006955 9.91 CXCL8 IFNG IL1B IL2 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B NOD2 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 IL1B NOD2 TNF
6 defense response GO:0006952 9.83 CXCL8 NOD2 TNF
7 regulation of signaling receptor activity GO:0010469 9.83 CXCL8 IFNG IL1B IL2 TNF
8 activation of MAPK activity GO:0000187 9.8 IL1B NOD2 TNF
9 positive regulation of JNK cascade GO:0046330 9.78 IL1B NOD2 TNF
10 cellular response to organic cyclic compound GO:0071407 9.77 IL1B NOD2 TNF
11 positive regulation of protein phosphorylation GO:0001934 9.76 IFNG IL1B IL2 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.74 IL1B NOD2 TNF
13 cytokine-mediated signaling pathway GO:0019221 9.72 CXCL8 IL1B IL2 NOS2 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 IL1B NOD2 TNF
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.69 IL1B IL2
16 cell-cell adhesion mediated by cadherin GO:0044331 9.68 CDH1 CDH3
17 negative regulation of neurogenesis GO:0050768 9.68 IL1B TNF
18 positive regulation of protein complex assembly GO:0031334 9.68 IFNG TNF
19 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
20 positive regulation of interferon-gamma production GO:0032729 9.67 IL1B IL2 TNF
21 embryonic digestive tract development GO:0048566 9.66 CXCL8 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
23 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B TNF
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG IL1B TNF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
26 regulation of regulatory T cell differentiation GO:0045589 9.64 IFNG IL2
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
28 positive regulation of interleukin-17 production GO:0032740 9.62 IL2 NOD2
29 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
30 regulation of establishment of endothelial barrier GO:1903140 9.6 IL1B TNF
31 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B TNF
32 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
33 positive regulation of killing of cells of other organism GO:0051712 9.55 IFNG NOS2
34 sequestering of triglyceride GO:0030730 9.54 IL1B TNF
35 positive regulation of interleukin-8 production GO:0032757 9.54 IL1B NOD2 TNF
36 regulation of insulin secretion GO:0050796 9.46 IFNG IL1B NOS2 TNF
37 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IFNG IL1B TNF
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
39 positive regulation of neutrophil chemotaxis GO:0090023 9.37 CXCL8
40 cellular response to lipopolysaccharide GO:0071222 9.35 CXCL8 IL1B NOD2 NOS2 TNF
41 chronic inflammatory response to antigenic stimulus GO:0002439 9.26 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IFNG IL1B IL2 TNF
Sources

Sources for Crohn's Colitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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