MCID: CRH005
MIFTS: 61

Crohn's Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Crohn's Colitis

MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis 12 15
Crohn Disease 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060192
ICD10 33 K50.1
ICD9CM 35 555.1
MeSH 44 D003424
SNOMED-CT 68 50440006 7620006

Summaries for Crohn's Colitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary : Crohn's Colitis, also known as crohn disease, is related to jejunoileitis and pyoderma, and has symptoms including diarrhea, rectal bleeding and skin lesions. An important gene associated with Crohn's Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Crohn's Colitis

Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 416)
# Related Disease Score Top Affiliating Genes
1 jejunoileitis 30.7 IL1B TNF
2 pyoderma 30.1 CXCL8 NOD2 TNF
3 pyoderma gangrenosum 30.1 CXCL8 NOD2 TNF
4 spondylarthropathy 29.9 NOD2 TNF
5 pneumonia 29.8 CXCL8 IL1B TNF
6 ulcerative colitis 29.8 CXCL8 IFNG IL1B IL2 NOD2 TNF
7 vaginitis 29.8 CXCL8 IL1B
8 familial mediterranean fever 29.7 IL1B NOD2 TNF
9 necrotizing fasciitis 29.6 CXCL8 IL2
10 colitis 29.6 CXCL8 IFNG IL1B IL2 NOD2 NOS2
11 lung disease 29.5 CXCL8 IL1B TNF
12 acute respiratory distress syndrome 29.5 CXCL8 IL1B TNF
13 pyelonephritis 29.5 CXCL8 IL1B TNF
14 appendicitis 29.5 CXCL8 IL1B TNF
15 arthritis 29.5 CXCL8 IFNG IL1B NOD2 TNF
16 blau syndrome 29.5 IL1B NOD2 TNF
17 cytomegalovirus infection 29.5 CXCL8 IL1B TNF
18 periodontal disease 29.5 CXCL8 IL1B TNF
19 psoriatic arthritis 29.5 IL1B NOD2 TNF
20 gastritis 29.4 CXCL8 IL1B NOS2
21 hemorrhagic fever 29.4 IFNG TNF
22 psoriasis 29.4 CXCL8 IFNG IL1B IL2 TNF
23 monocytic leukemia 29.3 CXCL8 IFNG IL1B TNF
24 hematopoietic stem cell transplantation 29.3 IFNG IL2 TNF
25 central nervous system vasculitis 29.3 IFNG IL1B TNF
26 neuritis 29.2 IFNG IL1B TNF
27 miliary tuberculosis 29.2 IFNG TNF
28 dengue hemorrhagic fever 29.2 CXCL8 IFNG TNF
29 meningitis 29.1 CXCL8 IFNG IL1B TNF
30 osteomyelitis 29.1 CXCL8 IFNG IL1B TNF
31 pulmonary sarcoidosis 29.0 IFNG IL2 TNF
32 systemic lupus erythematosus 29.0 CXCL8 IFNG IL1B IL2 TNF
33 rheumatoid arthritis 28.9 CXCL8 IFNG IL1B IL2 TNF
34 pleurisy 28.9 CXCL8 IFNG IL2 TNF
35 inflammatory bowel disease 28.8 CXCL8 IFNG IL1B IL2 NOD2 NOS2
36 intestinal disease 28.8 CDH1 CXCL8 IL1B IL2 NOD2 TNF
37 crohn's disease 12.3
38 inflammatory bowel disease 1 12.0
39 thiopurines, poor metabolism of, 1 11.2
40 inflammatory bowel disease 10 11.1
41 inflammatory bowel disease 13 11.1
42 inflammatory bowel disease 14 11.1
43 inflammatory bowel disease 17 11.1
44 inflammatory bowel disease 19 11.1
45 inflammatory bowel disease 25, autosomal recessive 11.1
46 inflammatory bowel disease 28, autosomal recessive 11.1
47 bile acid malabsorption, primary 10.9
48 autoimmune disease 6 10.9
49 inflammatory bowel disease 29 10.9
50 short bowel syndrome 10.9

Graphical network of the top 20 diseases related to Crohn's Colitis:



Diseases related to Crohn's Colitis

Symptoms & Phenotypes for Crohn's Colitis

Symptoms:

12
  • diarrhea
  • rectal bleeding
  • skin lesions
  • formation of ulcers

UMLS symptoms related to Crohn's Colitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Crohn's Colitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 IL1B IL2 NOD2 NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 IL1B IL2 NOD2 NOS2 TNF

MGI Mouse Phenotypes related to Crohn's Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 CDH1 IFNG IL1B IL2 NOS2 SLIT2
2 digestive/alimentary MP:0005381 9.95 CDH1 IFNG IL2 NOD2 NOS2 SLIT2
3 growth/size/body region MP:0005378 9.92 CDH1 IFNG IL1B IL2 NOD2 NOS2
4 endocrine/exocrine gland MP:0005379 9.91 CDH1 CDH3 IFNG IL2 NOS2 SLIT2
5 immune system MP:0005387 9.8 CDH1 IFNG IL1B IL2 NOD2 NOS2
6 integument MP:0010771 9.7 CDH1 CDH3 IFNG IL1B NOS2 SLIT2
7 mortality/aging MP:0010768 9.56 CDH1 IFNG IL1B IL2 NOD2 NOS2
8 neoplasm MP:0002006 9.1 CDH1 IFNG IL1B IL2 NOS2 TNF

Drugs & Therapeutics for Crohn's Colitis

Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
6
Ciprofloxacin Approved, Investigational Phase 4,Phase 2 85721-33-1 2764
7
Vancomycin Approved Phase 4 1404-90-6 14969 441141
8
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
9
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
10
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Prednisolone acetate Phase 4
13 Neuroprotective Agents Phase 4
14 Hormones Phase 4
15 Hormone Antagonists Phase 4
16 Antiemetics Phase 4
17 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
18 Methylprednisolone acetate Phase 4
19 Peripheral Nervous System Agents Phase 4,Phase 2
20 Autonomic Agents Phase 4
21 glucocorticoids Phase 4
22 Protective Agents Phase 4
23 Gastrointestinal Agents Phase 4
24 Gentamicins Phase 4
25 Antiprotozoal Agents Phase 4,Phase 2
26 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
27 Antiparasitic Agents Phase 4,Phase 2
28 Anti-Infective Agents Phase 4,Phase 2
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2
30 Topoisomerase Inhibitors Phase 4,Phase 2
31 Antibiotics, Antitubercular Phase 4,Phase 2
32 Antineoplastic Agents, Hormonal Phase 4
33 Anti-Bacterial Agents Phase 4,Phase 2
34 Antimalarials Phase 4
35 Antitubercular Agents Phase 4
36
Azathioprine Approved Phase 3,Phase 2 446-86-6 2265
37
Certolizumab pegol Approved Phase 3 428863-50-7
38
Adalimumab Approved Phase 3 331731-18-1 16219006
39 Antimetabolites, Antineoplastic Phase 3,Phase 2
40 Immunologic Factors Phase 3,Phase 2,Phase 1
41 Immunosuppressive Agents Phase 3,Phase 2
42 Antirheumatic Agents Phase 3,Phase 2
43 Antimetabolites Phase 3,Phase 2
44 Antibodies Phase 3,Phase 1
45 Immunoglobulins Phase 3,Phase 1
46
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
47 Cola Phase 2,Not Applicable
48 Anti-Inflammatory Agents, Non-Steroidal Phase 2
49 Analgesics Phase 2
50 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Manipulating the Microbiome in IBD by Antibiotics and FMT Active, not recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
2 Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease Unknown status NCT01817972 Phase 3 Azathioprine
3 Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis Recruiting NCT02435992 Phase 3 RPC1063;Placebo
4 An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease Recruiting NCT03467958 Phase 3 Ozanimod
5 A Placebo-Controlled Study of Oral Ozanimod as Maintenance Therapy for Moderately to Severely Active Crohn's Disease Recruiting NCT03464097 Phase 3 Ozanimod
6 Induction Study #1 of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease Recruiting NCT03440372 Phase 3 Ozanimod
7 Open-Label Extension and Safety Study for Patients With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144 Recruiting NCT02403323 Phase 3 etrolizumab
8 A Study to Assess Whether Etrolizumab is a Safe and Effective Treatment for Participants With Moderately to Severely Active Crohn's Disease (CD) Recruiting NCT02394028 Phase 3 Etrolizumab;Placebo
9 Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies Recruiting NCT02118584 Phase 3 Etrolizumab
10 A Study of the Efficacy and Safety of Etrolizumab in Ulcerative Colitis Participants Who Have Been Previously Exposed to Tumor Necrosis Factor (TNF) Inhibitors Recruiting NCT02100696 Phase 3 Etrozulimab;Placebo
11 A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis Recruiting NCT03524092 Phase 3 Mirikizumab;Mirikizumab;Placebo
12 An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1) Recruiting NCT03518086 Phase 3 Mirikizumab;Placebo
13 Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease Recruiting NCT02914561 Phase 3 Filgotinib;Placebo to match filgotinib
14 Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Ulcerative Colitis Recruiting NCT02914522 Phase 3 Filgotinib;Placebo to match filgotinib
15 BI 695501 Versus Humira in Patients With Active Crohn's Disease: a Trial Comparing Efficacy, Endoscopic Improvement, Safety, and Immunogenicity Active, not recruiting NCT02871635 Phase 3 BI 695501;HUMIRA
16 Filgotinib in Long-Term Extension Study of Adults With Crohn's Disease Enrolling by invitation NCT02914600 Phase 3 Filgotinib;Placebo
17 Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis Enrolling by invitation NCT02914535 Phase 3 Filgotinib;Placebo
18 Efficacy and Safety Study of Mongersen (GED-0301) for the Treatment of Subjects With Active Crohn's Disease Terminated NCT02596893 Phase 3 GED-0301;Placebo
19 A Long-term Active Treatment Study of Mongersen (GED-0301) in Subjects With Crohn's Disease Terminated NCT02641392 Phase 3 GED-0301
20 A Study of Efficacy and Safety of Mongersen (GED-0301) for the Treatment of Adult and Adolescent Subjects With Active Crohn's Disease Withdrawn NCT02974322 Phase 3 GED-0301;Placebo
21 Fecal Microbiota Transplant (FMT) in Pediatric Active Crohn's Colitis Completed NCT02330211 Phase 1, Phase 2
22 Efficacy and Safety of GLPG0634 in Subjects With Active Crohn's Disease Completed NCT02048618 Phase 2 GLPG0634;Placebo
23 An Investigational Study of Experimental Medication BMS-986165 in Patients With Moderate to Severe Crohn's Disease Recruiting NCT03599622 Phase 2 BMS-986165
24 Study to Evaluate the Testicular Safety of Filgotinib in Adult Males With Moderately to Severely Active Ulcerative Colitis Recruiting NCT03201445 Phase 2 Filgotinib;Placebo;Standard of Care
25 Efficacy and Safety Study of Apremilast to Treat Active Ulcerative Colitis Active, not recruiting NCT02289417 Phase 2 Apremilast;Placebo
26 Imuran Dosing in Crohn's Disease Study Terminated NCT00113503 Phase 2 Azathioprine weight-based dose;Azathioprine individualised dose
27 Study of Antibiotics in the Treatment of Colonic Crohn's Disease Terminated NCT00257699 Phase 2 Metronidazole placebo;ciprofloxacin placebo;ciprofloxacin;metronidazole
28 Evaluate PF-00547659 On Cerebrospinal Fluid Lymphocytes In Volunteers With Crohn's Disease Or Ulcerative Colitis Who Failed Or Did Not Tolerate Anti-TNFs Completed NCT01387594 Phase 1 lumbar puncture
29 Chromoendoscopy for Dysplasia Detection in Chronic Inflammatory Bowel Disease Unknown status NCT01505842 Not Applicable
30 RCT: HDWL vs Virtual Chromoendoscopy in the Detection of Intraepithelial Neoplasia in Longstanding Colitis Unknown status NCT02822352 Not Applicable
31 Risk Factors for Colorectal Cancer in Patients With Inflammatory Bowel Disease Undergoing Surveillance: a Prospective Cohort Study Unknown status NCT01464151
32 Development of Niv Score of Capsule Endoscopy in Patients With Crohn's (CECDAIic) Unknown status NCT01793376
33 Surgical Decision Making Among People With Inflammatory Bowel Disease Completed NCT00438711
34 Efficacy of Infliximab as a Rescue Therapy in Pediatric Acute Severe Colitis Completed NCT02170714
35 Chromoendoscopy for Ulcerative Colitis Surveillance Completed NCT00274209
36 Post-Marketing Use Of CT-P13 (Infliximab) For Standard Of Care Treatment Of Inflammatory Bowel Disease Completed NCT02539368 CT-P13;Remicade
37 A Longitudinal Study of Hermansky-Pudlak Syndrome Pulmonary Fibrosis Recruiting NCT02368340
38 Tailored Transition for IBD Adolescents Recruiting NCT02893670 Not Applicable
39 Entyvio (Vedolizumab) Long Term Safety Study Recruiting NCT02674308 Vedolizumab

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: crohn disease

Genetic Tests for Crohn's Colitis

Anatomical Context for Crohn's Colitis

MalaCards organs/tissues related to Crohn's Colitis:

41
Colon, Bone, T Cells, Skin, Small Intestine, Testes, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Colitis:

19
Colon Only

Publications for Crohn's Colitis

Articles related to Crohn's Colitis:

(show top 50) (show all 1023)
# Title Authors Year
1
New perspectives on the long-term outcome of segmental colectomy for Crohn's colitis: an observational study on 200 patients. ( 29511841 )
2018
2
Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis. ( 29023984 )
2018
3
IBD LIVE Case Series: Case 9: Do Race and Extraintestinal Manifestations Affect Treatment of Severe Crohn's Colitis? ( 29562279 )
2018
4
Segmental Resection versus Total Proctocolectomy for Crohn's Colitis: What is the Best Operation in the Setting of Medically Refractory Disease or Dysplasia? ( 29462390 )
2018
5
Anorexia Nervosa Complicating Pediatric Crohn Disease-Case Report and Literature Review. ( 30356737 )
2018
6
Association of Blepharitis and Ectropion With Tumor Necrosis Factor α Inhibitor Treatment in Crohn Disease. ( 30419086 )
2018
7
The Crohn's & Colitis Australia Inflammatory Bowel Disease Audit: Measuring the quality of care in Australia. ( 30525299 )
2018
8
Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index. ( 30083065 )
2018
9
Anti-NMDAR encephalitis in a patient with Crohn disease receiving adalimumab. ( 29988714 )
2018
10
Nonbacterial Thrombotic Endocarditis Associated With Crohn Disease. ( 29305852 )
2018
11
Familial Mediterranean fever mimicking Crohn disease: A case report. ( 29505533 )
2018
12
Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa: A Population-Based Analysis in the United States. ( 29800049 )
2018
13
Metastatic vulvovaginal Crohn disease in the setting of well-controlled intestinal disease. ( 30235375 )
2018
14
Differentiation Between Crohn Disease and Intestinal Tuberculosis in Children. ( 28489674 )
2018
15
A RARE CASE OF CROHN DISEASE COMPLICATED WITH STEROID MONOTHERAPY-RELATED RETROPHARYNGEAL ABSCESS AND INITIALLY MISINTERPRETED PYODERMA GANGRENOSUM DEVELOPMENT. ( 30063691 )
2018
16
Incidence and Risk Factors for Perianal Disease in Pediatric Crohn Disease Patients Followed in CEDATA-GPGE Registry. ( 28604511 )
2018
17
Changes in Hepcidin and Hemoglobin After Anti-TNF-alpha Therapy in Children and Adolescents With Crohn Disease. ( 28604512 )
2018
18
Long-term Outcomes of Infliximab Use for Pediatric Crohn Disease: A Canadian Multicenter Clinical Practice Experience. ( 28657923 )
2018
19
Outcomes after fecal diversion for colonic and perianal Crohn disease in children. ( 28889960 )
2018
20
Secondary Loss of Response to Infliximab in Pediatric Crohn Disease: Does It Matter How and When We Start? ( 28906316 )
2018
21
Impaired IL-10 Receptor-mediated Suppression in Monocyte From Patients With Crohn Disease. ( 29045353 )
2018
22
Is Anti-TNF Therapy Associated With an Increased Risk of Postoperative Morbidity After Surgery for Ileocolonic Crohn Disease? ( 29166360 )
2018
23
Penetrating Crohn disease: does it occur in the absence of stricturing disease? ( 29167943 )
2018
24
Prospective Comparison of Standard- Versus Low-Radiation-Dose CT Enterography for the Quantitative Assessment of Crohn Disease. ( 29261354 )
2018
25
Hyperadiponectinemia During Infliximab Induction Therapy in Pediatric Crohn Disease. ( 29287006 )
2018
26
Magnetic Resonance Enterography Cannot Replace Upper Endoscopy in Pediatric Crohn Disease: An Imagekids Sub-study. ( 29287012 )
2018
27
Anti-TNF Therapy Is Associated With an Increased Risk of Postoperative Morbidity After Surgery for Ileocolonic Crohn Disease: Results of a Prospective Nationwide Cohort. ( 29300710 )
2018
28
Using Quality Improvement to Increase Utilization of Enteral Therapy in Pediatric Crohn Disease: Results and Outcomes. ( 29315161 )
2018
29
Increases in IGF-1 After Anti-TNF-α Therapy Are Associated With Bone and Muscle Accrual in Pediatric Crohn Disease. ( 29329430 )
2018
30
Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. ( 29361088 )
2018
31
Pediatric Crohn disease is characterized by Th1 in the terminal ileum and Th1/Th17 immune response in the colon. ( 29397417 )
2018
32
Semiautomatic Assessment of the Terminal Ileum and Colon in Patients with Crohn Disease Using MRI (the VIGOR++ Project). ( 29428210 )
2018
33
Signet Ring Cell Carcinoma, Ileal Crohn Disease or Both? - A Case of Diagnostic Challenge. ( 29457051 )
2018
34
T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients. ( 29519712 )
2018
35
Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease. ( 29531862 )
2018
36
Global Variation in Use of Enteral Nutrition for Pediatric Crohn Disease. ( 29543696 )
2018
37
Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats. ( 29567541 )
2018
38
Ectopic intestinal mucosa implanted on the perianal skin of a patient with Crohn disease. ( 29634894 )
2018
39
Postoperative course of Crohn disease according to timing of bowel resection: Results from the CONNECT Study. ( 29668618 )
2018
40
Buruli (Bairnsdale) ulcer in the setting of long-term adalimumab treatment for Crohn disease. ( 29722190 )
2018
41
Reintervention Rate Following Emergency Surgery for Crohn Disease. ( 29733016 )
2018
42
Markers of lipid peroxidation and antioxidant status in the serum and saliva of patients with active Crohn disease. ( 29806822 )
2018
43
Malnutrition increases the risk of 30-day complications after surgery in pediatric patients with Crohn disease. ( 29843908 )
2018
44
Asians have more perianal Crohn disease and ocular manifestations compared with white Americans. ( 29876356 )
2018
45
Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease. ( 29881302 )
2018
46
Obesity Does Not Affect Early Outcomes in Children With Newly Diagnosed Crohn Disease. ( 29916950 )
2018
47
Diagnostic Value of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient in Assessment of the Activity of Crohn Disease: 1.5 or 3 T. ( 29958199 )
2018
48
Significance of Perianal Lesion in Pediatric Crohn Disease. ( 29992118 )
2018
49
Recalcitrant Vulval and Perineal Crohn Disease Responding to Hyperbaric Oxygen Therapy. ( 30036200 )
2018
50
Persistence of Muscle-bone Deficits Following Anti-tumour Necrosis Factor Therapy in Adolescents With Crohn Disease. ( 30052566 )
2018

Variations for Crohn's Colitis

Expression for Crohn's Colitis

Search GEO for disease gene expression data for Crohn's Colitis.

Pathways for Crohn's Colitis

Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CDH1 CXCL8 IFNG IL1B IL2 NOD2
2
Show member pathways
13.75 CDH1 CDH3 CXCL8 IL1B IL2 NOS2
3
Show member pathways
13.57 CXCL8 IFNG IL1B IL2 NOS2 TNF
4
Show member pathways
13.44 CDH1 CXCL8 IFNG IL1B IL2 TNF
5
Show member pathways
13.27 CXCL8 IFNG IL1B IL2 NOD2 NOS2
6
Show member pathways
13.21 CDH1 CXCL8 IL1B IL2 TNF
7
Show member pathways
12.84 CXCL8 IFNG IL1B IL2 TNF
8
Show member pathways
12.8 CXCL8 IFNG IL1B IL2 NOD2 NOS2
9 12.79 CDH1 CXCL8 IFNG IL2 NOS2
10
Show member pathways
12.76 CXCL8 IFNG IL1B IL2 TNF
11
Show member pathways
12.7 CXCL8 IFNG IL1B TNF
12
Show member pathways
12.56 IFNG IL1B IL2 NOD2 TNF
13
Show member pathways
12.55 IFNG IL1B IL2 NOS2 TNF
14 12.52 IFNG IL1B IL2 TNF
15
Show member pathways
12.41 IFNG IL1B IL2 TNF
16
Show member pathways
12.32 IFNG IL1B IL2 TNF
17
Show member pathways
12.32 CXCL8 IFNG IL1B TNF
18
Show member pathways
12.26 CXCL8 IFNG IL1B NOS2 TNF
19
Show member pathways
12.24 IFNG IL1B NOS2 TNF
20
Show member pathways
12.23 CXCL8 IFNG IL1B IL2 TNF
21
Show member pathways
12.21 CXCL8 IL1B NOS2 TNF
22 12.17 CDH1 IFNG NOS2 TNF
23 12.16 IFNG IL1B NOD2 NOS2 TNF
24
Show member pathways
12.15 IL1B IL2 TNF
25
Show member pathways
12.15 IFNG IL1B TNF
26 12.12 CXCL8 IL1B TNF
27
Show member pathways
12.09 CXCL8 IFNG IL1B NOS2 TNF
28 12.05 IFNG IL1B TNF
29
Show member pathways
12.05 CDH1 CXCL8 IFNG IL1B IL2
30
Show member pathways
12.05 IFNG IL1B IL2 TNF
31 12.01 IFNG IL1B TNF
32
Show member pathways
12 IFNG IL1B TNF
33 11.96 IFNG IL2 TNF
34 11.96 CXCL8 IL1B NOS2 TNF
35
Show member pathways
11.95 IFNG IL1B IL2 NOS2
36 11.93 IL1B NOD2 TNF
37 11.92 CXCL8 IFNG IL1B
38 11.88 CXCL8 IL1B TNF
39 11.86 CXCL8 IL1B TNF
40 11.84 CXCL8 IFNG IL1B TNF
41 11.81 CXCL8 IFNG IL1B NOS2
42 11.79 CXCL8 IFNG IL2
43 11.76 IFNG IL1B IL2 TNF
44
Show member pathways
11.72 CXCL8 IFNG IL2 TNF
45 11.71 CXCL8 IL1B NOS2 TNF
46 11.7 CXCL8 IFNG IL1B NOS2 TNF
47 11.67 CXCL8 IL1B TNF
48
Show member pathways
11.66 IFNG IL2 TNF
49 11.61 CXCL8 IFNG NOS2
50 11.61 CXCL8 IL1B TNF

GO Terms for Crohn's Colitis

Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 CDH1 CDH3 NOD2 TNF
2 extracellular space GO:0005615 9.43 CXCL8 IFNG IL1B IL2 SLIT2 TNF
3 extracellular region GO:0005576 9.17 CDH1 CXCL8 IFNG IL1B IL2 SLIT2
4 catenin complex GO:0016342 9.16 CDH1 CDH3

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 IFNG IL1B IL2 NOD2
2 positive regulation of gene expression GO:0010628 9.93 CDH3 IFNG IL1B TNF
3 immune response GO:0006955 9.91 CXCL8 IFNG IL1B IL2 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B NOD2 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B NOD2 TNF
6 defense response GO:0006952 9.83 CXCL8 NOD2 TNF
7 regulation of signaling receptor activity GO:0010469 9.83 CXCL8 IFNG IL1B IL2 TNF
8 activation of MAPK activity GO:0000187 9.8 IL1B NOD2 TNF
9 positive regulation of JNK cascade GO:0046330 9.78 IL1B NOD2 TNF
10 cellular response to organic cyclic compound GO:0071407 9.77 IL1B NOD2 TNF
11 positive regulation of protein phosphorylation GO:0001934 9.76 IFNG IL1B IL2 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.74 IL1B NOD2 TNF
13 cytokine-mediated signaling pathway GO:0019221 9.72 CXCL8 IL1B IL2 NOS2 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 IL1B NOD2 TNF
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.69 IL1B IL2
16 cell-cell adhesion mediated by cadherin GO:0044331 9.69 CDH1 CDH3
17 negative regulation of neurogenesis GO:0050768 9.68 IL1B TNF
18 positive regulation of protein complex assembly GO:0031334 9.68 IFNG TNF
19 positive regulation of neutrophil chemotaxis GO:0090023 9.68 CXCL8 IL1B
20 protein import into nucleus, translocation GO:0000060 9.67 IFNG TNF
21 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
22 positive regulation of interferon-gamma production GO:0032729 9.67 IL1B IL2 TNF
23 embryonic digestive tract development GO:0048566 9.66 CXCL8 TNF
24 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
25 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B TNF
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG IL1B TNF
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
28 regulation of regulatory T cell differentiation GO:0045589 9.64 IFNG IL2
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
30 positive regulation of interleukin-17 production GO:0032740 9.62 IL2 NOD2
31 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
32 regulation of establishment of endothelial barrier GO:1903140 9.6 IL1B TNF
33 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B TNF
34 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
35 chronic inflammatory response to antigenic stimulus GO:0002439 9.56 IL1B TNF
36 positive regulation of killing of cells of other organism GO:0051712 9.55 IFNG NOS2
37 sequestering of triglyceride GO:0030730 9.54 IL1B TNF
38 positive regulation of interleukin-8 production GO:0032757 9.54 IL1B NOD2 TNF
39 regulation of insulin secretion GO:0050796 9.46 IFNG IL1B NOS2 TNF
40 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IFNG IL1B TNF
41 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
42 cellular response to lipopolysaccharide GO:0071222 9.35 CXCL8 IL1B NOD2 NOS2 TNF
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IFNG IL1B IL2 TNF

Sources for Crohn's Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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