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MCID: CRH005
MIFTS: 61

Crohn's Colitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Crohn's Colitis

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MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis 12 15 17
Crohn Disease 45 74

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0060192
ICD9CM 36 555.1
MeSH 45 D003424
SNOMED-CT 69 50440006 7620006
ICD10 34 K50.1
Sources

Summaries for Crohn's Colitis

About this section
Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary : Crohn's Colitis, also known as crohn disease, is related to jejunoileitis and ileocolitis, and has symptoms including diarrhea, rectal bleeding and skin lesions. An important gene associated with Crohn's Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Crohn's Colitis

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Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 451)
# Related Disease Score Top Affiliating Genes
1 jejunoileitis 30.9 IL1B TNF
2 ileocolitis 30.5 NOD2 TNF
3 pyoderma 30.4 CXCL8 NOD2 TNF
4 pyoderma gangrenosum 30.4 CXCL8 NOD2 TNF
5 spondylarthropathy 30.4 NOD2 TNF
6 vaginitis 30.2 CXCL8 IL1B
7 cytomegalovirus infection 30.2 CXCL8 IL1B TNF
8 necrotizing fasciitis 30.0 CXCL8 IL2
9 familial mediterranean fever 30.0 IL1B NOD2 TNF
10 lung disease 29.9 CXCL8 IL1B TNF
11 acute respiratory distress syndrome 29.8 CXCL8 IL1B TNF
12 pyelonephritis 29.8 CXCL8 IL1B TNF
13 appendicitis 29.8 CXCL8 IL1B TNF
14 blau syndrome 29.8 IL1B NOD2 TNF
15 hemorrhagic fever 29.8 IFNG TNF
16 pneumonia 29.8 CXCL8 IL1B TNF
17 ulcerative colitis 29.8 CXCL8 IFNG IL1B IL2 NOD2 TNF
18 periodontal disease 29.8 CXCL8 IL1B TNF
19 colitis 29.7 CXCL8 IFNG IL1B IL2 NOD2 NOS2
20 psoriatic arthritis 29.7 IL1B NOD2 TNF
21 arthritis 29.7 CXCL8 IFNG IL1B NOD2 TNF
22 hematopoietic stem cell transplantation 29.6 IFNG IL2 TNF
23 central nervous system vasculitis 29.6 IFNG IL1B TNF
24 miliary tuberculosis 29.6 IFNG TNF
25 neuritis 29.6 IFNG IL1B TNF
26 monocytic leukemia 29.5 CXCL8 IFNG IL1B TNF
27 dengue hemorrhagic fever 29.5 CXCL8 IFNG TNF
28 gastritis 29.5 CXCL8 IL1B NOS2
29 inflammatory bowel disease 29.4 CXCL8 IFNG IL1B IL2 NOD2 TNF
30 brucellosis 29.4 CXCL8 IFNG IL2 TNF
31 pulmonary sarcoidosis 29.4 IFNG IL2 TNF
32 spinal cord injury 29.4 CXCL8 NOS2 TNF
33 meningitis 29.3 CXCL8 IFNG IL1B TNF
34 osteomyelitis 29.3 CXCL8 IFNG IL1B TNF
35 pleurisy 29.1 CXCL8 IFNG IL2 TNF
36 sarcoidosis 1 29.1 IFNG IL1B IL2 NOD2 TNF
37 rheumatoid arthritis 29.1 CXCL8 IFNG IL1B IL2 TNF
38 intestinal disease 28.7 CDH1 CXCL8 IL1B IL2 NOD2 TNF
39 inflammatory bowel disease 1 12.2
40 thiopurines, poor metabolism of, 1 11.3
41 inflammatory bowel disease 29 11.2
42 inflammatory bowel disease 10 11.1
43 inflammatory bowel disease 13 11.1
44 inflammatory bowel disease 14 11.1
45 inflammatory bowel disease 17 11.1
46 inflammatory bowel disease 19 11.1
47 inflammatory bowel disease 25, autosomal recessive 11.1
48 inflammatory bowel disease 28, autosomal recessive 11.1
49 bile acid malabsorption, primary 10.9
50 autoimmune disease 6 10.9

Graphical network of the top 20 diseases related to Crohn's Colitis:



Diseases related to Crohn's Colitis
Sources

Symptoms & Phenotypes for Crohn's Colitis

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Symptoms:

12
  • • diarrhea
  • • rectal bleeding
  • • skin lesions
  • • formation of ulcers

UMLS symptoms related to Crohn's Colitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Crohn's Colitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CXCL8 IL1B IL2 NOD2 NOS2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CXCL8 IL1B IL2 NOD2 NOS2 TNF

MGI Mouse Phenotypes related to Crohn's Colitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 CDH1 IFNG IL1B IL2 NOS2 SLIT2
2 digestive/alimentary MP:0005381 9.95 CDH1 IFNG IL2 NOD2 NOS2 SLIT2
3 growth/size/body region MP:0005378 9.92 CDH1 IFNG IL1B IL2 NOD2 NOS2
4 endocrine/exocrine gland MP:0005379 9.91 CDH1 CDH3 IFNG IL2 NOS2 SLIT2
5 immune system MP:0005387 9.8 CDH1 IFNG IL1B IL2 NOD2 NOS2
6 integument MP:0010771 9.7 CDH1 CDH3 IFNG IL1B NOS2 SLIT2
7 mortality/aging MP:0010768 9.56 CDH1 IFNG IL1B IL2 NOD2 NOS2
8 neoplasm MP:0002006 9.1 CDH1 IFNG IL1B IL2 NOS2 TNF
Sources

Drugs & Therapeutics for Crohn's Colitis

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Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 465)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
2
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
3
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
5
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
6
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
7
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
8
Rifabutin Approved, Investigational Phase 4,Phase 3 72559-06-9 6323490 46783538
9
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
11
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
13
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
14
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6, 15438-31-0 23925 27284
15
Prucalopride Approved Phase 4 179474-81-8
16
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
17
Mercaptopurine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-44-2 667490
18
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
19
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
21
Racepinephrine Approved Phase 4,Phase 2,Not Applicable 329-65-7 838
22
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 51-43-4 5816
23
Vancomycin Approved Phase 4,Phase 2 1404-90-6 441141 14969
24
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
25
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 564-25-0 54671203
26
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
27 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 943609-66-3
28
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
29
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
30
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
31
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
32
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
33
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
35
Azithromycin Approved Phase 4 83905-01-5 55185 447043
36
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
37
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
38
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
39
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
40
Phylloquinone Approved, Investigational Phase 4,Phase 1 84-80-0
41
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
42
Losartan Approved Phase 4 114798-26-4 3961
43
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
44
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
45
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
46
Dextromethorphan Approved Phase 4,Phase 1 125-71-3 5362449 5360696
47
Caffeine Approved Phase 4,Phase 1 58-08-2 2519
48
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 93-14-1 3516
49
Ustekinumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 815610-63-0
50
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474

Interventional clinical trials:

(show top 50) (show all 1310)
# Name Status NCT ID Phase Drugs
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
5 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
6 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
7 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
8 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
9 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
12 Does Clinical Response Correlate With Serum Certolizumab Levels? Unknown status NCT02597829 Phase 4 Certolizumab Pegol
13 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
14 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
15 Brief Escalation of Adalimumab Treatment for Prevention of Clinical Relapse in IBD Unknown status NCT03059849 Phase 4 Adalimumab
16 Anemia in Inflammatory Bowel Disease Unknown status NCT02760940 Phase 4 oral liposomal iron
17 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
18 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
19 Prucalopride Prior to Small Bowel Capsule Endoscopy Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
20 Manipulating the Microbiome in IBD by Antibiotics and FMT Active, not recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
21 Value of Pharmacokinetic Assays in the Prediction of Induction and Maintenance Therapeutic Response in Crohn's Disease Recruiting NCT02768532 Phase 4 Vedolizumab
22 Exclusive Enteral Nutrition and Corticosteroids Therapy in Crohn's Disease (EENCD) Recruiting NCT03833596 Phase 4 Prednisone
23 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
24 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
25 Ultrasound Evaluation of Crohn's Disease Enrolling by invitation NCT03235180 Phase 4 Sulfur Hexafluoride
26 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
27 Corticosteroids With Vedolizumab in Crohn's Disease Terminated NCT02324699 Phase 4 Prednisone;Placebo;Vedolizumab
28 The Effects of Parenteral ω-3 Polyunsaturated Fatty Acid on Postoperative Complications of Patients With Crohn's Disease Recruiting NCT03901937 Phase 4 ω-3 polyunsaturated fatty acid
29 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
30 Cimzia Versus Mesalamine for Crohn's Recurrence Terminated NCT01696942 Phase 4 Cimzia;Mesalamine
31 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
32 Top-down Infliximab Study in Kids With Crohn's Disease Active, not recruiting NCT02517684 Phase 4 Infliximab;Prednisolone;Azathioprine
33 Safety of Celecoxib in Patients With Crohn's Disease Terminated NCT00177866 Phase 4 Celebrex;placebo
34 Trial of High Dose Vitamin D in Patient's With Crohn's Disease Terminated NCT02208310 Phase 4 Cholecalciferol 10,000 IU;Cholecalciferol 400 IU
35 Reduce Risk for Crohn's Disease Patients Recruiting NCT02852694 Phase 4 Methotrexate;Adalimumab;Azathioprine / 6 Mercaptopurine
36 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
37 To Evaluate the Efficacy and Safety of Sirolimus for Crohn's Disease With Stenosis Recruiting NCT02675153 Phase 4 Sirolimus;5-ASA, Prednisone, Azathioprine or Remicade
38 A Study to Evaluate Efficacy, of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study Recruiting NCT02646683 Phase 4 vedolizumab
39 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
40 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
41 Efficacy and Safety of Top-down Therapy in Pediatric Crohn's Disease Withdrawn NCT01752790 Phase 4 Top-down;Step-up
42 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
43 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
44 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
45 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
46 Lengthening Adalimumab Dosing Interval in Quiescent Crohn's Disease Patients Recruiting NCT03172377 Phase 4
47 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
48 Pediatric Crohn's Disease AdalImumab Level-based Optimization Treatment (PAILOT) Trial Completed NCT02256462 Phase 4 Adalimumab
49 Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease Completed NCT02630966 Phase 4 Vedolizumab;Placebo
50 A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy Recruiting NCT02177071 Phase 4 INFLIXIMAB;AZATHIOPRINE;MERCAPTOPURINE;Methotrexate

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: crohn disease

Sources

Genetic Tests for Crohn's Colitis

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Anatomical Context for Crohn's Colitis

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MalaCards organs/tissues related to Crohn's Colitis:

42
Colon, Bone, Skin, T Cells, Testes, Small Intestine, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Colitis:

20
Colon Only
Sources

Publications for Crohn's Colitis

About this section

Articles related to Crohn's Colitis:

(show top 50) (show all 1132)
# Title Authors Year
1
Backwash ileitis in ulcerative colitis: Are there MR enterographic features that distinguish it from Crohn disease? ( 30599862 )
2019
2
Efficacy of Preoperative Oral Antibiotic Prophylaxis for the Prevention of Surgical Site Infections in Patients With Crohn Disease: A Randomized Controlled Trial. ( 29064884 )
2019
3
Comparison of MRI Activity Scoring Systems and Features for the Terminal Ileum in Patients With Crohn Disease. ( 30540212 )
2019
4
Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. ( 30542108 )
2019
5
Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease. ( 30604884 )
2019
6
Anti-interleukin 12/23 in the treatment of erythema nodosum and Crohn disease: A case report. ( 30620119 )
2019
7
Enterourachal Fistula as an Initial Presentation in Crohn Disease. ( 30671379 )
2019
8
Long-term Results of the Side-to-side Isoperistaltic Strictureplasty in Crohn Disease: 25-year Follow-up and Outcomes. ( 30720502 )
2019
9
Comparison of three oral contrast preparations for magnetic resonance enterography in pediatric patients with known or suspected Crohn disease: a prospective randomized trial. ( 30852650 )
2019
10
Is Crohn Disease the price to pay today for having survived to the Black Death? ( 30893422 )
2019
11
New perspectives on the long-term outcome of segmental colectomy for Crohn's colitis: an observational study on 200 patients. ( 29511841 )
2018
12
Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis. ( 29023984 )
2018
13
IBD LIVE Case Series: Case 9: Do Race and Extraintestinal Manifestations Affect Treatment of Severe Crohn's Colitis? ( 29562279 )
2018
14
Segmental Resection versus Total Proctocolectomy for Crohn's Colitis: What is the Best Operation in the Setting of Medically Refractory Disease or Dysplasia? ( 29462390 )
2018
15
Anorexia Nervosa Complicating Pediatric Crohn Disease-Case Report and Literature Review. ( 30356737 )
2018
16
Association of Blepharitis and Ectropion With Tumor Necrosis Factor α Inhibitor Treatment in Crohn Disease. ( 30419086 )
2018
17
The Crohn's & Colitis Australia Inflammatory Bowel Disease Audit: Measuring the quality of care in Australia. ( 30525299 )
2018
18
Enteric Virome and Bacterial Microbiota in Children with Ulcerative Colitis and Crohn's Disease. ( 30169455 )
2018
19
Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index. ( 30083065 )
2018
20
Anti-NMDAR encephalitis in a patient with Crohn disease receiving adalimumab. ( 29988714 )
2018
21
Nonbacterial Thrombotic Endocarditis Associated With Crohn Disease. ( 29305852 )
2018
22
Familial Mediterranean fever mimicking Crohn disease: A case report. ( 29505533 )
2018
23
Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa: A Population-Based Analysis in the United States. ( 29800049 )
2018
24
Metastatic vulvovaginal Crohn disease in the setting of well-controlled intestinal disease. ( 30235375 )
2018
25
A RARE CASE OF CROHN DISEASE COMPLICATED WITH STEROID MONOTHERAPY-RELATED RETROPHARYNGEAL ABSCESS AND INITIALLY MISINTERPRETED PYODERMA GANGRENOSUM DEVELOPMENT. ( 30063691 )
2018
26
Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease. ( 29881302 )
2018
27
Incidence and Risk Factors for Perianal Disease in Pediatric Crohn Disease Patients Followed in CEDATA-GPGE Registry. ( 28604511 )
2018
28
Changes in Hepcidin and Hemoglobin After Anti-TNF-alpha Therapy in Children and Adolescents With Crohn Disease. ( 28604512 )
2018
29
Long-term Outcomes of Infliximab Use for Pediatric Crohn Disease: A Canadian Multicenter Clinical Practice Experience. ( 28657923 )
2018
30
Outcomes after fecal diversion for colonic and perianal Crohn disease in children. ( 28889960 )
2018
31
Secondary Loss of Response to Infliximab in Pediatric Crohn Disease: Does It Matter How and When We Start? ( 28906316 )
2018
32
Impaired IL-10 Receptor-mediated Suppression in Monocyte From Patients With Crohn Disease. ( 29045353 )
2018
33
Is Anti-TNF Therapy Associated With an Increased Risk of Postoperative Morbidity After Surgery for Ileocolonic Crohn Disease? ( 29166360 )
2018
34
Penetrating Crohn disease: does it occur in the absence of stricturing disease? ( 29167943 )
2018
35
Prospective Comparison of Standard- Versus Low-Radiation-Dose CT Enterography for the Quantitative Assessment of Crohn Disease. ( 29261354 )
2018
36
Hyperadiponectinemia During Infliximab Induction Therapy in Pediatric Crohn Disease. ( 29287006 )
2018
37
Magnetic Resonance Enterography Cannot Replace Upper Endoscopy in Pediatric Crohn Disease: An Imagekids Sub-study. ( 29287012 )
2018
38
Anti-TNF Therapy Is Associated With an Increased Risk of Postoperative Morbidity After Surgery for Ileocolonic Crohn Disease: Results of a Prospective Nationwide Cohort. ( 29300710 )
2018
39
Using Quality Improvement to Increase Utilization of Enteral Therapy in Pediatric Crohn Disease: Results and Outcomes. ( 29315161 )
2018
40
Increases in IGF-1 After Anti-TNF-α Therapy Are Associated With Bone and Muscle Accrual in Pediatric Crohn Disease. ( 29329430 )
2018
41
Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. ( 29361088 )
2018
42
Pediatric Crohn disease is characterized by Th1 in the terminal ileum and Th1/Th17 immune response in the colon. ( 29397417 )
2018
43
Semiautomatic Assessment of the Terminal Ileum and Colon in Patients with Crohn Disease Using MRI (the VIGOR++ Project). ( 29428210 )
2018
44
Signet Ring Cell Carcinoma, Ileal Crohn Disease or Both? - A Case of Diagnostic Challenge. ( 29457051 )
2018
45
T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients. ( 29519712 )
2018
46
Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease. ( 29531862 )
2018
47
Global Variation in Use of Enteral Nutrition for Pediatric Crohn Disease. ( 29543696 )
2018
48
Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats. ( 29567541 )
2018
49
Ectopic intestinal mucosa implanted on the perianal skin of a patient with Crohn disease. ( 29634894 )
2018
50
Postoperative course of Crohn disease according to timing of bowel resection: Results from the CONNECT Study. ( 29668618 )
2018
Sources

Variations for Crohn's Colitis

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Expression for Crohn's Colitis

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Search GEO for disease gene expression data for Crohn's Colitis.
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Pathways for Crohn's Colitis

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Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.91 CDH1 CXCL8 IFNG IL1B IL2 NOD2
2
ERK Signaling 65
Show member pathways
 13.75 CDH1 CDH3 CXCL8 IL1B IL2 NOS2
3
PEDF Induced Signaling 65
Show member pathways
 13.57 CXCL8 IFNG IL1B IL2 NOS2 TNF
4
TGF-Beta Pathway 65
Show member pathways
 13.44 CDH1 CXCL8 IFNG IL1B IL2 TNF
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.27 CXCL8 IFNG IL1B IL2 NOD2 NOS2
6
PAK Pathway 65
Show member pathways
 13.21 CDH1 CXCL8 IL1B IL2 TNF
7
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 12.97 CXCL8 IFNG IL1B IL2 NOD2 NOS2
8
Allograft rejection 1 38
Show member pathways
 12.84 CXCL8 IFNG IL1B IL2 TNF
9
Pathways in cancer 38
12.8 CDH1 CXCL8 IFNG IL2 NOS2
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.7 CXCL8 IFNG IL1B TNF
11
Th17 cell differentiation 38
Show member pathways
 12.56 IFNG IL1B IL2 NOD2 TNF
12
Influenza A 38
Show member pathways
 12.55 CXCL8 IFNG IL1B IL2 TNF
13
Immune response IL-23 signaling pathway 23
Show member pathways
 12.55 IFNG IL1B IL2 NOS2 TNF
14
NF-kappaB Signaling 4
12.52 IFNG IL1B IL2 TNF
15
T cell receptor signaling pathway 38
Show member pathways
 12.41 IFNG IL1B IL2 TNF
16
Selenium Micronutrient Network 1
Show member pathways
 12.32 IFNG IL1B IL2 TNF
17
IL-17 Family Signaling Pathways 66
Show member pathways
 12.32 CXCL8 IFNG IL1B TNF
18
Toll Comparative Pathway 65
Show member pathways
 12.26 CXCL8 IFNG IL1B NOS2 TNF
19
Toxoplasmosis 38
Show member pathways
 12.24 IFNG IL1B NOS2 TNF
20
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.23 CXCL8 IFNG IL1B IL2 TNF
21
IL-1 Family Signaling Pathways 66
Show member pathways
 12.21 CXCL8 IL1B NOS2 TNF
22
Colorectal Cancer Metastasis 65
12.17 CDH1 IFNG NOS2 TNF
23
Tuberculosis 38
12.16 IFNG IL1B NOD2 NOS2 TNF
24
C-type lectin receptor signaling pathway 38
Show member pathways
 12.15 IL1B IL2 TNF
25
Necroptosis 38
Show member pathways
 12.15 IFNG IL1B TNF
26
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.12 CXCL8 IL1B TNF
27
Bacterial infections in CF airways 23
Show member pathways
 12.09 CXCL8 IFNG IL1B NOS2 TNF
28
Fluid shear stress and atherosclerosis 38
12.05 IFNG IL1B TNF
29
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.05 CDH1 CXCL8 IFNG IL1B IL2
30
Th1 Differentiation Pathway 66
Show member pathways
 12.05 IFNG IL1B IL2 TNF
31
Osteoclast differentiation 38
12.01 IFNG IL1B TNF
32
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12 IFNG IL1B TNF
33
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.96 IFNG IL2 TNF
34
Interleukin-4 and 13 signaling 67
11.96 CXCL8 IL1B NOS2 TNF
35
IL12-mediated signaling events 1
Show member pathways
 11.95 IFNG IL1B IL2 NOS2
36
TNF signaling pathway 38
11.93 IL1B NOD2 TNF
37
Senescence and Autophagy in Cancer 1
11.92 CXCL8 IFNG IL1B
38
AGE-RAGE signaling pathway in diabetic complications 38
11.89 CXCL8 IL1B TNF
39
NF-kappa B signaling pathway 38
11.86 CXCL8 IL1B TNF
40
Rheumatoid arthritis 38
11.84 CXCL8 IFNG IL1B TNF
41
Salmonella infection (KEGG) 38
11.81 CXCL8 IFNG IL1B NOS2
42
Glucocorticoid receptor regulatory network 1
11.79 CXCL8 IFNG IL2
43
Innate Lymphoid Cell Differentiation Pathways 66
11.76 IFNG IL1B IL2 TNF
44
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.72 CXCL8 IFNG IL2 TNF
45
Pertussis 38
11.71 CXCL8 IL1B NOS2 TNF
46
Amoebiasis 38
11.7 CXCL8 IFNG IL1B NOS2 TNF
47
Lung fibrosis 1
11.67 CXCL8 IL1B TNF
48
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.66 IFNG IL2 TNF
49
ATF-2 transcription factor network 1
11.61 CXCL8 IFNG NOS2
50
Legionellosis 38
11.61 CXCL8 IL1B TNF
Sources

GO Terms for Crohn's Colitis

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Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 CDH1 CDH3 NOD2 TNF
2 extracellular space GO:0005615 9.43 CXCL8 IFNG IL1B IL2 SLIT2 TNF
3 extracellular region GO:0005576 9.17 CDH1 CXCL8 IFNG IL1B IL2 SLIT2
4 catenin complex GO:0016342 9.16 CDH1 CDH3

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 IFNG IL1B IL2 NOD2
2 positive regulation of gene expression GO:0010628 9.93 CDH3 IFNG IL1B TNF
3 immune response GO:0006955 9.91 CXCL8 IFNG IL1B IL2 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B NOD2 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 IL1B NOD2 TNF
6 defense response GO:0006952 9.83 CXCL8 NOD2 TNF
7 regulation of signaling receptor activity GO:0010469 9.83 CXCL8 IFNG IL1B IL2 TNF
8 activation of MAPK activity GO:0000187 9.8 IL1B NOD2 TNF
9 positive regulation of JNK cascade GO:0046330 9.78 IL1B NOD2 TNF
10 cellular response to organic cyclic compound GO:0071407 9.77 IL1B NOD2 TNF
11 positive regulation of protein phosphorylation GO:0001934 9.76 IFNG IL1B IL2 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.74 IL1B NOD2 TNF
13 cytokine-mediated signaling pathway GO:0019221 9.72 CXCL8 IL1B IL2 NOS2 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 IL1B NOD2 TNF
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.69 IL1B IL2
16 cell-cell adhesion mediated by cadherin GO:0044331 9.68 CDH1 CDH3
17 negative regulation of neurogenesis GO:0050768 9.68 IL1B TNF
18 positive regulation of protein complex assembly GO:0031334 9.68 IFNG TNF
19 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
20 positive regulation of interferon-gamma production GO:0032729 9.67 IL1B IL2 TNF
21 embryonic digestive tract development GO:0048566 9.66 CXCL8 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
23 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B TNF
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG IL1B TNF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
26 regulation of regulatory T cell differentiation GO:0045589 9.64 IFNG IL2
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
28 positive regulation of interleukin-17 production GO:0032740 9.62 IL2 NOD2
29 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
30 regulation of establishment of endothelial barrier GO:1903140 9.6 IL1B TNF
31 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B TNF
32 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
33 positive regulation of killing of cells of other organism GO:0051712 9.55 IFNG NOS2
34 sequestering of triglyceride GO:0030730 9.54 IL1B TNF
35 positive regulation of interleukin-8 production GO:0032757 9.54 IL1B NOD2 TNF
36 regulation of insulin secretion GO:0050796 9.46 IFNG IL1B NOS2 TNF
37 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IFNG IL1B TNF
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
39 positive regulation of neutrophil chemotaxis GO:0090023 9.37 CXCL8
40 cellular response to lipopolysaccharide GO:0071222 9.35 CXCL8 IL1B NOD2 NOS2 TNF
41 chronic inflammatory response to antigenic stimulus GO:0002439 9.26 TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IFNG IL1B IL2 TNF
Sources

Sources for Crohn's Colitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
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47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
77