Crohn's Colitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRH005 MIFTS: 51	Crohn's Colitis Categories: Gastrointestinal diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Crohn's Colitis

MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis ¹¹ ¹⁴ ¹⁶

Crohn Disease ⁴³ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the digestive system

Noninfective enteritis and colitis

Crohn disease [regional enteritis]

Crohn disease of large intestine

External Ids:

Disease Ontology ¹¹ DOID:0060192

ICD9CM ³⁴ 555.1

MeSH ⁴³ D003424

NCIt ⁴⁹ C37262

SNOMED-CT ⁶⁸ 7620006

ICD10 ³¹ K50.1

EFO ¹⁶ EFO_0005622

UMLS ⁷¹ C0010346 C0156147

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Summaries for Crohn's Colitis

Disease Ontology: ¹¹ An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary: Crohn's Colitis, also known as crohn disease, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and ileocolitis, and has symptoms including diarrhea, skin lesions and rectal bleeding. An important gene associated with Crohn's Colitis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Immune response IL-23 signaling pathway. The drugs Mercaptopurine and Prucalopride have been mentioned in the context of this disorder. Affiliated tissues include colon only, bone marrow and colon, and related phenotypes are homeostasis/metabolism and immune system

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Related Diseases for Crohn's Colitis

Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1148)

#	Related Disease	Score	Top Affiliating Genes
1	vitiligo-associated multiple autoimmune disease susceptibility 1	31.7	TNF IL17A CCR6
2	ileocolitis	31.0	TNF NOD2 ATG16L1
3	toxic megacolon	30.9	TNF CRP CCR6
4	intestinal tuberculosis	30.9	TNF NOD2 CRP
5	proctitis	30.7	TNF CRP CCR6
6	inflammatory bowel disease 5	30.6	NOD2 IRGM CCR6 ATG16L1
7	interstitial nephritis	30.6	TNF CRP CCR6
8	granulomatous dermatitis	30.6	TNF NOD2 CRP
9	pouchitis	30.5	TNF NOD2
10	serum amyloid a amyloidosis	30.4	TNF IL6 CRP
11	actinomycosis	30.4	TNF IL10 CRP
12	miliary tuberculosis	30.3	TNF IL10 CRP
13	amyloidosis	30.3	TNF IL6 IL1B CRP
14	hidradenitis suppurativa	30.2	TNF NOD2 IL1B IL17A CRP
15	takayasu arteritis	30.2	TNF IL6 IL10 CRP
16	hidradenitis	30.2	TNF NOD2 IL1B IL17A CRP
17	bowel dysfunction	30.2	TNF NOD2 IL6 IL1B IL10 CRP
18	granulomatosis with polyangiitis	30.2	TNF IL17A CRP CCR6
19	clostridium difficile colitis	30.2	IL1B CRP CCR6
20	blau syndrome	30.2	TNF NOD2 IL1B IL10
21	anogenital venereal wart	30.1	TNF IL6 CCR6
22	melkersson-rosenthal syndrome	30.1	TNF NOD2 CRP
23	gastrointestinal tuberculosis	30.1	TNF NOD2 CRP
24	abdominal tuberculosis	30.1	TNF NOD2 CRP
25	diverticulitis	30.1	TNF IL6 CRP CCR6
26	pyoderma gangrenosum	30.1	TNF NOD2 IL1B CCR6
27	lepromatous leprosy	30.0	TNF IL10 CCR6
28	autoimmune pancreatitis	30.0	IL10 CRP CCR6
29	retinal artery occlusion	30.0	IL6 IL10 CRP
30	pustulosis of palm and sole	30.0	TNF IL17A CRP CCR6
31	henoch-schoenlein purpura	30.0	TNF IL6 CRP CCR6
32	stomatitis	30.0	TNF IL6 IL1B IL10
33	relapsing polychondritis	30.0	TNF IL6 CRP
34	ischemic colitis	30.0	TNF IL6 CRP CCR6
35	intestinal perforation	30.0	TNF NOD2 IL6 IL10 CRP CCR6
36	lymph node tuberculosis	30.0	TNF CRP
37	nocardiosis	30.0	TNF CRP
38	pancreatitis	30.0	TNF IL6 IL1B IL10 CRP
39	intestinal obstruction	29.9	TNF NOD2 IL6 CRP
40	polyarteritis nodosa	29.9	TNF IL6 CRP
41	nutritional deficiency disease	29.9	IL6 CRP CCR6
42	conjunctivitis	29.9	TNF IL6 IL10
43	dacryoadenitis	29.9	IL17A IL10 CCR6
44	corneal ulcer	29.9	TNF IL6 IL1B
45	diarrhea	29.9	TNF NOD2 IL6 IL1B IL10
46	periostitis	29.9	TNF IL1B CRP
47	neutrophilic dermatosis, acute febrile	29.8	TNF IL1B IL17A CRP
48	inflammatory bowel disease 18	29.8	NOD2 IL17A IL10 CCR6 ATG16L1
49	pericardial effusion	29.8	TNF IL6 CRP
50	pleurisy	29.8	TNF IL1B CRP

Graphical network of the top 20 diseases related to Crohn's Colitis:

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Symptoms & Phenotypes for Crohn's Colitis

Symptoms:

¹¹

• diarrhea
• skin lesions

• rectal bleeding
• formation of ulcers

UMLS symptoms related to Crohn's Colitis:

nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Colitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.03	AQP8 ATG16L1 CCR6 CRP DEFB103A DEFB103B
2	immune system	MP:0005387	9.8	ATG16L1 CCR6 CRP DEFB103A DEFB103B DEFB4A
3	hematopoietic system	MP:0005397	9.44	ATG16L1 CCR6 DEFB103A DEFB103B DEFB4A IL10

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Drugs & Therapeutics for Crohn's Colitis

Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 337)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Mercaptopurine

Approved

Phase 4

50-44-2

667490

Prucalopride

Approved

Phase 4

179474-81-8

3052762

Ondansetron

Approved, Withdrawn

Phase 4

99614-02-5

4595

Azithromycin

Approved

Phase 4

83905-01-5

447043

Phylloquinone

Approved, Investigational

Phase 4

84-80-0

5284607

Esketamine

Approved, Investigational

Phase 4

33643-46-8

182137

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1, 1867-66-9

3821

Sulfamethazine

Approved, Investigational, Vet_approved

Phase 4

57-68-1

5327

Risedronic acid

Approved, Investigational

Phase 4

105462-24-6

5245

Golimumab

Approved

Phase 4

476181-74-5

Posaconazole

Approved, Investigational, Vet_approved

Phase 4

171228-49-2

147912

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Mesalazine

Approved

Phase 4

89-57-6

4075

Methotrexate

Approved

Phase 4

1959-05-2, 59-05-2

4112 126941

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 4

1401-55-4

16129878 16129778

Levoleucovorin

Approved, Experimental, Investigational

Phase 4

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Celecoxib

Approved, Investigational

Phase 4

169590-42-5

2662

Menadione

Approved, Nutraceutical

Phase 4

58-27-5

4055

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 4

59-30-3

6037

Menaquinone

Investigational

Phase 4

1182-68-9

Hepcidins

Phase 4

Serotonin Receptor Agonists

Phase 4

Parenteral Nutrition Solutions

Phase 4

Fat Emulsions, Intravenous

Phase 4

Soybean oil, phospholipid emulsion

Phase 4

Soy Bean

Phase 4

Vaccines

Phase 4

Chrysarobin

Phase 4

Heptavalent Pneumococcal Conjugate Vaccine

Phase 4

Adrenergic beta-Agonists

Phase 4

Adrenergic alpha-Agonists

Phase 4

Adrenergic Agonists

Phase 4

Adrenergic Agents

Phase 4

Vasoconstrictor Agents

Phase 4

Mydriatics

Phase 4

Sympathomimetics

Phase 4

Vitamin K

Phase 4

Antifibrinolytic Agents

Phase 4

Hemostatics

Phase 4

Naphthoquinone

Phase 4

Coagulants

Phase 4

Antidepressive Agents

Phase 4

Diphosphonates

Phase 4

calcium channel blockers

Phase 4

Vitamin K 1

Phase 4

Tin Fluorides

Phase 4

Interleukin-12

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

Hormone Antagonists

Phase 4

Interventional clinical trials:

(show top 50) (show all 1420)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized, Controlled, Single-blind Study of Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult	Unknown status	NCT02056418	Phase 4	corticosteroid
2	The Impact of Serum Vitamin D and Calcium Levels on the Body Composition, Bone Mineral Density, Muscle Strength, Exercise Tolerance, Fatigue and Inflammatory Activity in Patients With Crohn's Disease: a Randomized Controlled Trial	Unknown status	NCT02704624	Phase 4
3	Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China	Unknown status	NCT03901937	Phase 4	ω-3 polyunsaturated fatty acid
4	Can Vitamin D Supplementation in People With Crohn's Disease Improve Symptoms as an Adjunct Therapy? D-CODE Feasibility Randomised Controlled Trial	Unknown status	NCT03718182	Phase 4
5	Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease	Unknown status	NCT00609752	Phase 4	prednisolone
6	The Effect of Prucalopride on Small Bowel Transit Time in Patients Undergoing Capsule Endoscopy: A Randomized Controlled Trial	Unknown status	NCT02806206	Phase 4	Prucalopride;Placebo
7	Stricture Definition and Treatment (STRIDENT) Drug Therapy Study	Unknown status	NCT03220841	Phase 4	Adalimumab Injection;Thiopurine
8	Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy	Unknown status	NCT00851565	Phase 4
9	Evaluation of PET CT in the Management of Patients With Crohn's Disease.	Unknown status	NCT00731809	Phase 4
10	Does Clinical Response Correlate With Serum Certolizumab Levels? A Prospective Open Label Trial of Adult Patients With Active Crohn's Disease (APOLLO)	Unknown status	NCT02597829	Phase 4	Certolizumab Pegol
11	A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease	Unknown status	NCT01632462	Phase 4	VSL#3
12	Santeon InflixMab biosimILAr Research A Randomized, Controlled, Double Blind, Phase 4 Noninferiority Trial to Assess Efficacy of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission.	Unknown status	NCT02452151	Phase 4	Infliximab-Biosimilar;Infliximab-Innovator
13	Optimizing Response in Crohn's Disease Patients Who Have Insufficient Initial Response or Who Have Loss of Successful Response to Certolizumab Pegol (Cimzia) Induction Therapy	Unknown status	NCT01024647	Phase 4
14	The Effect of Probiotics on Bowel Disease	Unknown status	NCT01078935	Phase 4
15	Double-blind Placebo Controlled Trial of VSL#3 in Children With Crohn's Disease	Unknown status	NCT00367705	Phase 4
16	Phase IV Study Comparing a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis	Unknown status	NCT00265772	Phase 4	MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
17	The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation	Unknown status	NCT01765998	Phase 4	Probiotic;Placebo
18	Risk-stratified Randomized Controlled Trial in Paediatric Crohn Disease:Methotrexate vs Azathioprine or Adalimumab for Maintaining Remission in Patients at Low or High Risk for Aggressive Disease Course, respectively-a Treatment Strategy	Unknown status	NCT02852694	Phase 4	Methotrexate;Adalimumab;Azathioprine / 6 Mercaptopurine
19	Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients	Completed	NCT01180452	Phase 4
20	EUS Guided Treatment With Humira for Crohn's Perianal Fistulas	Completed	NCT00517296	Phase 4	adalimumab
21	Ultra-proactive Therapeutic Drug Monitoring of Infliximab Based on Point-of-care-testing in Inflammatory Bowel Disease: a Pragmatic Trial	Completed	NCT04775732	Phase 4
22	An Open-Label, Phase 4 Study to Evaluate the Efficacy and Safety of Triple Combination Therapy With Vedolizumab IV, Adalimumab SC, and Oral Methotrexate in Early Treatment of Subjects With Crohn's Disease Stratified at Higher Risk for Developing Complications	Completed	NCT02764762	Phase 4	Vedolizumab;Adalimumab;Methotrexate
23	Influence of Immunosuppressive Treatment on Immunological Response to Pneumococcal Conjugated Vaccine (PCV13) in Patients With Inflammatory Bowel Disease	Completed	NCT01908283	Phase 4
24	A Prospective Randomized Trial of Transversus Abdominis Plane (TAP) INtraoperative Block With Bupivacaine/Dexamethasone aGainst Liposomal Bupivacaine (Exparel®): the TINGLE Trial	Completed	NCT03723447	Phase 4	Liposomal bupivacaine;Bupivacaine/epinephrine/dexamethasone
25	Modulation of Immune Function by Parenteral Fish Oil in Patients With Crohn's Disease and High Inherent Tumor Necrosis Factor-alpha Production: a Randomized, Single Blinded, Cross-over Study	Completed	NCT02349594	Phase 4	Omegaven 10%;Intralipid 20%
26	Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission: A Multi-center, Double Blinded, Randomized, Placebo Controlled Study	Completed	NCT01817426	Phase 4	Infliximab
27	A Pilot Study to Evaluate the Applicability of the Crohn's Disease Endoscopy Index of Severity to Data Obtained by the Colonic Capsule Endoscopy in Ileocolonic Crohn's Disease	Completed	NCT01183845	Phase 4
28	Effects of Intraoperative Low-dose S-ketamine on Postoperative Mood and Pain in Patients With Crohn's Disease Undergoing Enterectomy With Mild to Moderate Depression: a Randomized Controlled Trial	Completed	NCT05506787	Phase 4	Esketamine;Placebo
29	Phase 4, Open Lable Non Randomized un Controlled Study. Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation	Completed	NCT02269358	Phase 4	METHOTREXATE
30	The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease: a Placebo-controlled Randomized Trial	Completed	NCT02010762	Phase 4	Vitamin D;Placebo
31	Microarray Analysis of Peripheral Blood and Tissues of Patients With Immune Mediated Inflammatory Diseases	Completed	NCT00462072	Phase 4	Infliximab
32	A Cluster Randomized Controlled Trial of an Enhanced Treatment Algorithm for the Management of Crohn's Disease	Completed	NCT01698307	Phase 4
33	Rapidity of Onset of Response to Adalimumab in Luminal Crohn's Disease (RAPIDA Study)	Completed	NCT02148718	Phase 4
34	Effect of Early Prescription of Immunosuppressants on First Three-year Course of Crohn's Disease	Completed	NCT00546546	Phase 4	early immunosuppressants (azathioprine, methotrexate)
35	Pediatric Crohn's Disease AdalImumab Level-based Optimization Treatment (PAILOT) Trial	Completed	NCT02256462	Phase 4	Adalimumab
36	A Randomized Double-Blind Phase 4 Study to Evaluate the Safety and Proportion of Subjects With Fistula Healing in 2 Dose Regimens of Entyvio (Vedolizumab IV) in the Treatment of Fistulizing Crohn's Disease (ENTERPRISE)	Completed	NCT02630966	Phase 4	Vedolizumab;Placebo
37	Treatment of Iron Deficiency Anaemia in Adults and Adolescents With Inflammatory Bowel Disease Using Ferrous Sulphate: Tolerance and Effects on Haemoglobin, Mood, Quality of Life and Fatigue	Completed	NCT01991314	Phase 4	Ferrous sulphate
38	Pneumococcal Vaccination of Crohn Patients - A Randomized, Non-blinded Phase 4 Clinical Trial With the Purpose of Investigating the Immune Response Against Two Different Pneumococcal Vaccines in Patients With Crohn's Disease	Completed	NCT01947010	Phase 4
39	The Ideal Management of Crohn's Disease: Top Down Versus Step Up Strategies. A Prospective Controlled Trial in the Benelux	Completed	NCT00554710	Phase 4	infliximab+azathioprine;methylprednisolone or budesonide
40	Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery	Completed	NCT00688636	Phase 4	infliximab;placebo
41	An Open-Label, Multicenter and Open Enrollment Model, Postmarketing, Milk-Only Lactation Study to Assess Concentration of Vedolizumab in Breast Milk of Lactating Women With Active Ulcerative Colitis or Crohn's Disease Who Are Receiving Vedolizumab Therapeutically	Completed	NCT02559713	Phase 4	Vedolizumab
42	A RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP STUDY TO EVALUATE THE SAFETY AND EFFICACY OF SWITCHING FROM INNOVATOR INFLIXIMAB TO BIOSIMILAR INFLIXIMAB COMPARED WITH CONTINUED TREATMENT WITH INNOVATOR INFLIXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, PSORIATIC ARTHRITIS, ULCERATIVE COLITIS, CROHN'S DISEASE AND CHRONIC PLAQUE PSORIASIS THE NOR-SWITCH STUDY	Completed	NCT02148640	Phase 4	Innovator infliximab;Biosimilar infliximab
43	A Randomized, Single Blinded, Controlled, Multi Center Phase 4 Study for Induction of Remission in Active Pediatric Crohn's Disease, Using 2 Months Antibiotic Course of Azithromycin Combined With Metronidazole vs. Metronidazole Alone.	Completed	NCT01596894	Phase 4	Azithromycin + Metronidazole;Metronidazole
44	The Influence of 5-Aminosalicylates on Thiopurine Metabolite Levels	Completed	NCT00167882	Phase 4	5-aminosalicylate (Pentasa, Ferring)
45	A Cluster Randomized Controlled Trial of a Treatment Algorithm for the Management of Crohn's Disease	Completed	NCT01030809	Phase 4
46	Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease	Completed	NCT00114465	Phase 4	VSL#3
47	Multicentre, Controlled, Randomised, Open, Cross-over Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tbl. 500 mg in Children With Crohn´s Disease	Completed	NCT00225810	Phase 4	Crohn's Disease
48	A Phase III, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Antegren™ (Natalizumab) in Crohn's Disease Subjects Who Have Previously Participated in Antegren Crohn's Disease Studies	Completed	NCT00280956	Phase 4	natalizumab
49	Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease	Completed	NCT00588653	Phase 4
50	The Effect of Vitamin K Supplementation on Bone Health Indices in Adult Crohn's Disease	Completed	NCT01235325	Phase 4

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

aminosalicylic acid

Azathioprine

Cholecalciferol

natalizumab

Opium

OPIUM ALKALOIDS HYDROCHLORIDE

OPIUM, POWDERED

paregoric

Thalidomide

Cochrane evidence based reviews: crohn disease

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Genetic Tests for Crohn's Colitis

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Anatomical Context for Crohn's Colitis

Organs/tissues related to Crohn's Colitis:

FMA: Colon Only

MalaCards : Bone Marrow, Colon, Bone, Placenta, Skin, Small Intestine, T Cells

Sources

Publications for Crohn's Colitis

Articles related to Crohn's Colitis:

(show top 50) (show all 898)

#	Title	Authors	PMID	Year
1	Image-Enhanced Endoscopy Surveillance of Colon and Pouch Dysplasia in IBD. ⁶²	Parigi TL...Iacucci M	35867688	2022
2	Strongyloides colitis, a rare but important mimic of Crohn's disease, resulting in coma and multi-organ failure: a case report. ⁶²	Saqib SU...Patel A	36447071	2022
3	State-of-the-art surgery for Crohn's disease: Part II-colonic Crohn's disease and associated neoplasms. ⁶²	Macleod A...Galandiuk S	35729401	2022
4	Confocal laser endomicroscope with distal MEMS scanner for real-time histopathology. ⁶²	Lee M...Wang TD	36418439	2022
5	High-dose vitamin C therapy for symptomatic deficiency in a patient with myasthenia gravis and Crohn's disease. ⁶²	Murphree J...Adams D	34784069	2022
6	Use of complementary and alternative medicine (CAM) in patients with inflammatory bowel disease (IBD): results from a German nationwide survey of 2019 compared to a previous survey of 2002. ⁶²	Bauer N...Langhorst J	35722930	2022
7	Adalimumab therapy in pediatric Crohn's Disease: a two-year follow-up comparing 'top-down' and 'step-up' strategies. ⁶²	Payen E...Pigneur B	36305799	2022
8	Correction: PLGA-microspheres-carried circGMCL1 protects against Crohn's colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy. ⁶²	Zhao J...Tang L	36123329	2022
9	PLGA-microspheres-carried circGMCL1 protects against Crohn's colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy. ⁶²	Zhao J...Tang L	36088391	2022
10	Remestemcel-L allogeneic bone marrow-derived mesenchymal stem cell product to treat medically refractory Crohn's colitis: preliminary phase IB/IIA study. ⁶²	Lightner AL...Steele SR	35714218	2022
11	Colorectal Strictures in Patients With Inflammatory Bowel Disease Do Not Independently Predict Colorectal Neoplasia. ⁶²	Axelrad JE...Shah SC	34319381	2022
12	Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview. ⁶²	M'Koma AE	35629984	2022
13	Emphysematous cystitis as a potential marker of severe Crohn's disease. ⁶²	Hasan SMM...Salh BS	35410166	2022
14	Acute Myopericarditis in the Setting of Crohn's Colitis: Challenging Management Decisions. ⁶²	Daloya J...Korlipara G	35399407	2022
15	Small Bowel Crohn's Disease Recurrence is Common After Total Proctocolectomy for Crohn's Colitis. ⁶²	Hollis RH...Lightner AL	34759246	2022
16	Acute myocarditis revealing autoimmune and inflammatory disorders: Clinical presentation and outcome. ⁶²	Chaligne C...Sacre K	34979146	2022
17	Crohn's Disease Diagnosed in a Man with Sarcoidosis: Coincidence or Correspondence? ⁶²	Mills K...Fas N	35669381	2022
18	Colour me blue: chromoendoscopy and advanced detection methods in ulcerative colitis. ⁶²	Kiesslich R	34871195	2022
19	5-Aminosalicylic Acid Chemoprevention in Inflammatory Bowel Diseases: Is It Necessary in the Age of Biologics and Small Molecules? ⁶²	Herfarth H...Vavricka SR	35224015	2022
20	Validation of the Padova Prognostic Score for Colitis in Predicting Long-Term Outcome After Restorative Proctocolectomy. ⁶²	Angriman I...Scarpa M	35959125	2022
21	Isolated Crohn's Colitis: Is Localization Crucial? Characteristics of Pediatric Patients From the CEDATA-GPGE Registry. ⁶²	Elonen L...CEDATA-GPGE-Study-Group	35712614	2022
22	Stem Cell Therapy for the Treatment of Crohn's Disease; Current Obstacles and Future Hopes. ⁶²	El-Nakeep S	34514993	2022
23	SULT1A1 and SULT1A2 Associated Extensive Prolapse-Type Inflammatory Polyposis in Crohn's Colitis. ⁶²	Zhou T...Wu H	34921041	2021
24	Potassium bromate (KBrO3) modulates oxidative stress and inflammatory biomarkers in sodium hydroxide (NaOH) - induced Crohn's colitis in Wistar rats. ⁶²	Salami AT...Olaleye SB	33848442	2021
25	Total Transperineal Laparoscopic Proctectomy for the Treatment of Crohn's Proctitis. ⁶²	Springer JE...Maykel JA	34285146	2021
26	Role of Extended Mesenteric Excision in Postoperative Recurrence of Crohn's Colitis: A Single-Center Study. ⁶²	Zhu Y...Zhu W	34597277	2021
27	The long-term incidence of dysplasia and colorectal cancer in a Crohn's colitis population-based cohort. ⁶²	Gatenby G...Eglinton T	34041848	2021
28	Assessing effectiveness and patient perceptions of a novel electronic medical record for the management of inflammatory bowel disease. ⁶²	Kaazan P...Andrews JM	34584976	2021
29	Multicentre randomised controlled trial on virtual chromoendoscopy in the detection of neoplasia during colitis surveillance high-definition colonoscopy (the VIRTUOSO trial). ⁶²	Kandiah K...Bhandari P	33214162	2021
30	Continent ileostomy: short- and long-term outcomes of a forgotten procedure. ⁶²	Ecker NKJ...Ecker KW	34686880	2021
31	Severity of complications following restorative proctocolectomy in children is related to staging not diagnosis. ⁶²	O'Connor E...Jaffray B	32972742	2021
32	Molecular characterization of ulcerative colitis-associated colorectal carcinomas. ⁶²	Hirsch D...Gaiser T	33318582	2021
33	Atypical case of Crohn's colitis in a patient with adult-onset Still's disease. ⁶²	Narayanan A...Dennett ER	34130968	2021
34	Long term remission after ileorectal anastomosis in Crohn's colitis. ⁶²	Salice M...Gionchetti P	32616463	2021
35	Transperineal total mesorectal excision for rectal cancer on the residual rectum after multiple abdominal surgeries in a patient with Crohn's disease: a case report. ⁶²	Emoto S...Taketomi A	33983535	2021
36	Initial experience with transanal proctectomy in children. ⁶²	Traynor MD...Potter DD	33358416	2021
37	Chylomicrons-Simulating Sustained Drug Release in Mesenteric Lymphatics for the Treatment of Crohn's-Like Colitis. ⁶²	Yin Y...Li Y	32978613	2021
38	Perceptive eating as part of the journey in inflammatory bowel disease: Lessons learned from lived experience. ⁶²	Nowlin S...Gorbenko K	33487280	2021
39	Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. ⁶²	Rana T...M'Koma AE	33690604	2021
40	Colorectal cancer in Crohn's colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study. ⁶²	Vetter LE...Weber GF	32918621	2021
41	Colonic Crohn's disease - decision is more important than incision: A surgical dilemma. ⁶²	Chiarello MM...Brisinda G	33552390	2021
42	The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis. ⁶²	Jorandli JW...van Beelen Granlund A	32967429	2020
43	Crohn's Colitis Care (CCCare): bespoke cloud-based clinical management software for inflammatory bowel disease. ⁶²	Krishnaprasad K...Andrews JM	33161791	2020
44	Kayexalate-induced colitis and rectal stricture. ⁶²	Krishnamurthy P...Agrawal S	33318260	2020
45	Efficacy of biosimilar infliximab CT-P13 among inpatients with severe steroid-refractory colitis. ⁶²	Ollech JE...Sakuraba A	32710391	2020
46	High-Definition Chromoendoscopy Superior to High-Definition White-Light Endoscopy in Surveillance of Inflammatory Bowel Diseases in a Randomized Trial. ⁶²	Alexandersson B...Schmidt PT	32353535	2020
47	Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications. ⁶²	Lawday S...Antoniou SA	32236745	2020
48	Recurrent pericarditis in an adolescent with Crohn's colitis. ⁶²	Das BB...Guzman A	32863666	2020
49	Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis. ⁶²	Huang Q...Chen Y	32706073	2020
50	Laparoscopic total proctocolectomy for Crohn's colitis - a video vignette. ⁶²	Ng ZQ...Salama P	31970846	2020

Sources

Genes for Crohn's Colitis

Genes related to Crohn's Colitis (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.64	DISEASES inferred ¹⁴ ¹⁴
2	TNF	Tumor Necrosis Factor	Protein Coding	6.1	DISEASES inferred ¹⁴
3	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	6.06	DISEASES inferred ¹⁴
4	DEFA5	Defensin Alpha 5	Protein Coding	5.62	DISEASES inferred ¹⁴
5	ATG16L1	Autophagy Related 16 Like 1	Protein Coding	5.28	DISEASES inferred ¹⁴
6	CRP	C-Reactive Protein	Protein Coding	5.19	DISEASES inferred ¹⁴
7	G0S2	G0/G1 Switch 2	Protein Coding	5.14	DISEASES inferred ¹⁴
8	IL10	Interleukin 10	Protein Coding	5.13	DISEASES inferred ¹⁴
9	ARMH3	Armadillo Like Helical Domain Containing 3	Protein Coding	5.03	DISEASES inferred ¹⁴
10	AQP8	Aquaporin 8	Protein Coding	5.02	DISEASES inferred ¹⁴
11	DEFB4A	Defensin Beta 4A	Protein Coding	4.97	DISEASES inferred ¹⁴
12	SLC15A5	Solute Carrier Family 15 Member 5	Protein Coding	4.97	DISEASES inferred ¹⁴
13	DEFB103A	Defensin Beta 103A	Protein Coding	4.94	DISEASES inferred ¹⁴
14	DEFB103B	Defensin Beta 103B	Protein Coding	4.94	DISEASES inferred ¹⁴
15	IRGM	Immunity Related GTPase M	Protein Coding	4.89	DISEASES inferred ¹⁴
16	IL17A	Interleukin 17A	Protein Coding	4.88	DISEASES inferred ¹⁴
17	IL1B	Interleukin 1 Beta	Protein Coding	4.84	DISEASES inferred ¹⁴
18	IL6	Interleukin 6	Protein Coding	4.84	DISEASES inferred ¹⁴
19	TEDC2	Tubulin Epsilon And Delta Complex 2	Protein Coding	4.72	DISEASES inferred ¹⁴
20	PLPPR5	Phospholipid Phosphatase Related 5	Protein Coding	4.72	DISEASES inferred ¹⁴

Sources

Variations for Crohn's Colitis

Sources

Expression for Crohn's Colitis

Search GEO for disease gene expression data for Crohn's Colitis.

Sources

Pathways for Crohn's Colitis

Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 35)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.92	TNF NOD2 IL6 IL1B IL17A IL10
2	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.53	TNF IL6 IL1B IL17A IL10
3	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.45	TNF NOD2 IL6 IL1B
4	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.35	TNF IL6 IL1B DEFB4A
5	Defensins ⁶⁶ Show member pathways Alpha-defensins ⁶⁶ Antimicrobial peptides ⁶⁶ Beta defensins ⁶⁶ Ion influx/efflux at host-pathogen interface ⁶⁶ Metal sequestration by antimicrobial proteins ⁶⁶	12.26	DEFB4A DEFB103B DEFB103A DEFA5 CCR6
6	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.11	TNF IL6 IL1B IL10
7	Neuroinflammation and glutamatergic signaling ⁷⁴	12.05	TNF IL6 IL1B IL10
8	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.86	IL10 IL17A IL1B IL6 TNF
9	Allograft rejection ⁷⁴	11.85	TNF IL1B IL17A IL10
10	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.8	IL6 IL1B IL17A
11	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.77	TNF IL6 IL1B IL17A IL10
12	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.71	TNF IL6 IL1B IL10
13	Burn wound healing ⁷⁴	11.7	TNF IL6 IL1B
14	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.68	TNF IL6 IL10 CRP
15	Th17 cell differentiation pathway ⁷⁴	11.66	IL6 IL1B IL17A
16	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.61	TNF IL6 IL1B
17	Lung fibrosis ⁷⁴	11.61	TNF IL6 IL1B
18	miRNAs involvement in the immune response in sepsis ⁷⁴	11.6	TNF IL6 IL10
19	IL 10 signaling pathway ⁶⁷	11.6	TNF IL6 IL1B IL10
20	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.57	TNF NOD2 IL6 IL10
21	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.49	TNF NOD2 IL6 DEFB4A
22	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.45	IL1B IL6 TNF
23	Interleukin-10 signaling ⁶⁶	11.43	TNF IL6 IL1B IL10
24	IL-10 Pathway ⁶⁴	11.25	TNF IL6 IL1B IL10
25	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.24	TNF IL6 IL1B
26	Development and heterogeneity of the ILC family ⁷⁴	11.13	TNF IL6 IL1B IL17A
27	LDL- influence on CD14 and TLR4 ⁷⁴	11.07	IL10 IL1B IL6
28	Cytokines and inflammatory response ⁷⁴	11.02	TNF IL6 IL1B IL10
29	Overview of nanoparticle effects ⁷⁴	11.01	TNF IL6 CRP
30	G-protein signaling_Rap2B regulation pathway ²²	10.96	TNF IL6 IL1B IL17A IL10
31	Innate Lymphoid Cells Differentiation ⁶⁵	10.92	TNF IL1B IL17A IL10 CCR6
32	Prostaglandin signaling ⁷⁴	10.9	TNF IL6 IL1B IL17A
33	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.74	IL6 IL1B
34	Immune infiltration in pancreatic cancer ⁷⁴	10.69	TNF IL6 IL17A IL10
35	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.32	TNF IL6

Sources

GO Terms for Crohn's Colitis

Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	9.23	DEFB4A DEFB103B DEFB103A DEFA5

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 36)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	10.39	CRP IL17A IL1B IL6 IRGM TNF
2	immune response	GO:0006955	10.3	TNF IL6 IL1B IL17A IL10 DEFB4A
3	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.24	IL10 IL1B IL6 TNF
4	cell chemotaxis	GO:0060326	10.19	DEFB4A DEFB103B DEFB103A CCR6
5	positive regulation of interleukin-6 production	GO:0032755	10.16	IL17A IL1B IL6 NOD2 TNF
6	regulation of insulin secretion	GO:0050796	10.15	TNF IL6 IL1B
7	positive regulation of interleukin-1 beta production	GO:0032731	10.15	TNF NOD2 IL6 IL17A
8	response to activity	GO:0014823	10.14	TNF IL6 IL10
9	positive chemotaxis	GO:0050918	10.13	DEFB4A DEFB103B DEFB103A
10	cellular response to lipopolysaccharide	GO:0071222	10.13	DEFA5 IL10 IL1B IL6 IRGM NOD2
11	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.11	TNF IL6 IL10
12	defense response to fungus	GO:0050832	10.11	IL17A DEFB4A DEFA5
13	defense response to bacterium	GO:0042742	10.1	TNF NOD2 IRGM IL10 DEFB4A DEFB103B
14	liver regeneration	GO:0097421	10.08	TNF IL6 IL10
15	killing of cells of another organism	GO:0031640	10.08	DEFB4A DEFB103B DEFB103A DEFA5
16	negative regulation of neurogenesis	GO:0050768	10.07	TNF IL6 IL1B
17	positive regulation of interleukin-8 production	GO:0032757	10.07	TNF NOD2 IL6 IL1B DEFA5
18	positive regulation of chemokine production	GO:0032722	10.06	TNF IL6 IL1B
19	positive regulation of glial cell proliferation	GO:0060252	10.04	TNF IL6 IL1B
20	positive regulation of heterotypic cell-cell adhesion	GO:0034116	10.01	IL10 IL1B TNF
21	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.01	TNF NOD2 IL6 IL17A
22	positive regulation of neuroinflammatory response	GO:0150078	10	TNF IL6 IL1B
23	killing by host of symbiont cells	GO:0051873	9.99	DEFB103B DEFB103A DEFA5
24	negative regulation of lipid storage	GO:0010888	9.97	TNF IL6 CRP
25	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO:0002925	9.96	TNF NOD2
26	negative regulation of cytokine production involved in immune response	GO:0002719	9.95	TNF IL10
27	positive regulation of fever generation	GO:0031622	9.95	TNF IL1B
28	protein lipidation involved in autophagosome assembly	GO:0061739	9.93	IRGM ATG16L1
29	negative regulation of interleukin-18 production	GO:0032701	9.92	NOD2 IL10
30	sequestering of triglyceride	GO:0030730	9.92	TNF IL1B
31	vascular endothelial growth factor production	GO:0010573	9.91	TNF IL6 IL1B
32	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.9	TNF IL1B
33	chronic inflammatory response to antigenic stimulus	GO:0002439	9.88	IL10 TNF
34	defense response	GO:0006952	9.81	TNF NOD2 IRGM DEFB4A DEFB103B DEFB103A
35	defense response to Gram-negative bacterium	GO:0050829	9.8	DEFA5 DEFB103A DEFB103B DEFB4A IL17A IL6
36	defense response to Gram-positive bacterium	GO:0050830	9.6	TNF NOD2 IL6 IL1B IL17A DEFB4A

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.65	TNF IL6 IL1B IL17A IL10
2	chemoattractant activity	GO:0042056	9.63	DEFB4A DEFB103B DEFB103A
3	CCR6 chemokine receptor binding	GO:0031731	9.1	DEFB4A DEFB103B DEFB103A