MCID: CRH005
MIFTS: 53

Crohn's Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Crohn's Colitis

MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis 12 15 17
Crohn Disease 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060192
ICD9CM 34 555.1
MeSH 43 D003424
NCIt 49 C35211
SNOMED-CT 67 7620006
ICD10 32 K50.1
UMLS 71 C0010346 C0156147

Summaries for Crohn's Colitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary : Crohn's Colitis, also known as crohn disease, is related to inflammatory bowel disease 1 and jejunoileitis, and has symptoms including diarrhea, skin lesions and rectal bleeding. An important gene associated with Crohn's Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include colon only, colon and bone, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Crohn's Colitis

Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 799)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 1 32.7 TNF NOD2 DEFB4A CCR6 ATG16L1
2 jejunoileitis 31.0 TNF IL1B
3 intestinal tuberculosis 31.0 TNF NOD2 IFNG
4 pustulosis of palm and sole 30.8 TNF CXCL8 CCR6
5 hidradenitis suppurativa 30.8 TNF NOD2 IL1B IFNG
6 hidradenitis 30.8 TNF NOD2 IL1B IFNG
7 cytomegalovirus infection 30.7 TNF IL1B CXCL8
8 pouchitis 30.7 NOD2 CXCL8
9 proctitis 30.6 TNF NOD2 CCR6
10 blau syndrome 30.6 TNF NOD2 IL1B
11 amebiasis 30.6 TNF IL1B CXCL8
12 takayasu arteritis 30.5 TNF IL2 IL1B
13 appendicitis 30.5 TNF IL2 IL1B IFNG CXCL8
14 ileocolitis 30.5 TNF NOD2 ATG16L1
15 irritable bowel syndrome 30.4 TNF IL1B CXCL8
16 retinal vascular disease 30.4 TNF IL1B CXCL8
17 leukemia, acute monocytic 30.4 TNF IL1B CXCL8
18 iritis 30.4 TNF NOD2 CCR6
19 esophagitis 30.4 TNF IL1B CXCL8
20 peritonitis 30.3 TNF NOS2 IL1B IFNG CXCL8
21 monocytic leukemia 30.3 TNF IL1B IFNG CXCL8
22 sclerosing cholangitis 30.3 TNF NOD2 IL2 CXCL8
23 cholangitis 30.3 TNF NOD2 IL2 CXCL8
24 histoplasmosis 30.3 TNF IFNG CCR6
25 familial mediterranean fever 30.3 TNF NOD2 IL1B CXCL8
26 stomatitis 30.3 TNF IL2 IL1B IFNG CXCL8
27 peptic esophagitis 30.3 TNF IL1B CXCL8
28 chronic granulomatous disease 30.3 TNF IL1B IFNG CXCL8
29 vaginal discharge 30.3 TNF IL1B CXCL8
30 pulmonary tuberculosis 30.3 TNF IL2 IL1B IFNG
31 neutropenia 30.3 TNF IL2 IL1B IFNG CXCL8
32 myositis 30.3 TNF IL1B IFNG CXCL8
33 bronchopneumonia 30.2 TNF IL1B CXCL8
34 macular retinal edema 30.2 TNF IL1B CXCL8
35 osteomyelitis 30.2 TNF NOD2 IL1B IFNG CXCL8
36 pharyngitis 30.2 TNF IL1B CXCL8
37 adult-onset still's disease 30.2 TNF IL1B CXCL8
38 necrotizing fasciitis 30.2 IL2 IL1B CXCL8
39 keratitis, hereditary 30.2 TNF IL1B CCR6
40 microscopic colitis 30.2 TNF IL2 IFNG
41 pyoderma gangrenosum 30.2 TNF NOD2 CXCL8 CCR6
42 retinal vein occlusion 30.2 TNF IL1B CXCL8
43 gastrointestinal tuberculosis 30.2 TNF NOD2 IFNG
44 measles 30.2 TNF IL2 IL1B IFNG CXCL8
45 endocarditis 30.2 TNF IFNG CXCL8
46 ileus 30.1 TNF IL1B IFNG
47 brucellosis 30.1 TNF IL2 IFNG CXCL8
48 optic neuritis 30.1 TNF IL1B CXCL8
49 blepharitis 30.1 TNF IL1B CCR6
50 inflammatory bowel disease 5 30.1 NOD2 CCR6 ATG16L1

Graphical network of the top 20 diseases related to Crohn's Colitis:



Diseases related to Crohn's Colitis

Symptoms & Phenotypes for Crohn's Colitis

Symptoms:

12
  • diarrhea
  • skin lesions
  • rectal bleeding
  • formation of ulcers

UMLS symptoms related to Crohn's Colitis:


nausea and vomiting, abdominal pain, constipation, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 ATG16L1 CDH1 IFNG IL2 NOD2 NOS2
2 neoplasm MP:0002006 9.17 CDH1 IFNG IL1B IL2 NOS2 TMEFF2

Drugs & Therapeutics for Crohn's Colitis

Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 352)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
4
Rifabutin Approved, Investigational Phase 4 72559-06-9 6323490 46783538
5
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
6
Prucalopride Approved Phase 4 179474-81-8
7
Metronidazole Approved Phase 4 443-48-1 4173
8
Azithromycin Approved Phase 4 83905-01-5 447043 55185
9
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
10
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
11
Ustekinumab Approved, Investigational Phase 4 815610-63-0
12
Ondansetron Approved Phase 4 99614-02-5 4595
13
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
14
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
15
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
16
Vancomycin Approved Phase 4 1404-90-6 14969 441141
17
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
19
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
20
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
21
Racepinephrine Approved Phase 4 329-65-7 838
22
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
23
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
24
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
25
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
26
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
27
Caffeine Approved Phase 4 58-08-2 2519
28
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
29
Losartan Approved Phase 4 114798-26-4 3961
30
Certolizumab pegol Approved Phase 4 428863-50-7
31
tannic acid Approved Phase 4 1401-55-4
32
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
33
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
34
Mercaptopurine Approved Phase 4 50-44-2 667490
35
leucovorin Approved Phase 4 58-05-9 6006 143
36
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
37
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
38
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
39 Antifungal Agents Phase 4
40 Serotonin Receptor Agonists Phase 4
41 Anti-Bacterial Agents Phase 4
42 Antiprotozoal Agents Phase 4
43 Antiparasitic Agents Phase 4
44 Antibiotics, Antitubercular Phase 4
45 calcium channel blockers Phase 4
46 Vitamin K 1 Phase 4
47 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
48 Fat Emulsions, Intravenous Phase 4
49 Soybean oil, phospholipid emulsion Phase 4
50 Parenteral Nutrition Solutions Phase 4

Interventional clinical trials:

(show top 50) (show all 1188)
# Name Status NCT ID Phase Drugs
1 Does Clinical Response Correlate With Serum Certolizumab Levels? A Prospective Open Label Trial of Adult Patients With Active Crohn's Disease (APOLLO) Unknown status NCT02597829 Phase 4 Certolizumab Pegol
2 A Randomized, Controlled, Single-blind Study of Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
3 Santeon InflixMab biosimILAr Research A Randomized, Controlled, Double Blind, Phase 4 Noninferiority Trial to Assess Efficacy of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission. Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
4 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation Unknown status NCT01765998 Phase 4 Probiotic;Placebo
5 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
6 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
7 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
8 The Effect of Probiotics on Bowel Disease Unknown status NCT01078935 Phase 4
9 Optimizing Response in Crohn's Disease Patients Who Have Insufficient Initial Response or Who Have Loss of Successful Response to Certolizumab Pegol (Cimzia) Induction Therapy Unknown status NCT01024647 Phase 4
10 Efficacy and Safety of Sirolimus in the Treatment of Crohn's Disease With Stenosis Unknown status NCT02675153 Phase 4 Sirolimus;5-ASA, Prednisone, Azathioprine or Remicade
11 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission: A Multi-center, Double Blinded, Randomized, Placebo Controlled Study Unknown status NCT01817426 Phase 4 Infliximab
12 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
13 Phase IV Study Comparing a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
14 Double-blind Placebo Controlled Trial of VSL#3 in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
15 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
16 The Effect of Prucalopride on Small Bowel Transit Time in Patients Undergoing Capsule Endoscopy: A Randomized Controlled Trial Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
17 Vitamin D and Immunomodulation: Effects in Crohn's Disease Completed NCT01369667 Phase 4
18 Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients Completed NCT01180452 Phase 4
19 Rapidity of Onset of Response to Adalimumab in Luminal Crohn's Disease (RAPIDA Study) Completed NCT02148718 Phase 4
20 EUS Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
21 Vitamin D and Its Effects on Inflammation and Intestinal Permeability in Crohn's Disease in Remission Completed NCT01792388 Phase 4
22 A Pilot Study to Evaluate the Applicability of the Crohn's Disease Endoscopy Index of Severity to Data Obtained by the Colonic Capsule Endoscopy in Ileocolonic Crohn's Disease Completed NCT01183845 Phase 4
23 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
24 A Phase III, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Antegren™ (Natalizumab) in Crohn's Disease Subjects Who Have Previously Participated in Antegren Crohn's Disease Studies Completed NCT00280956 Phase 4 natalizumab
25 A RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP STUDY TO EVALUATE THE SAFETY AND EFFICACY OF SWITCHING FROM INNOVATOR INFLIXIMAB TO BIOSIMILAR INFLIXIMAB COMPARED WITH CONTINUED TREATMENT WITH INNOVATOR INFLIXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, PSORIATIC ARTHRITIS, ULCERATIVE COLITIS, CROHN'S DISEASE AND CHRONIC PLAQUE PSORIASIS THE NOR-SWITCH STUDY Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
26 Immunogenicity of Hepatitis A Vaccine in Patients With Inflammatory Bowel Disease Completed NCT01341808 Phase 4
27 Effect of Early Prescription of Immunosuppressants on First Three-year Course of Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
28 The Effect of Vitamin K Supplementation on Bone Health Indices in Adult Crohn's Disease Completed NCT01235325 Phase 4
29 Serological Response to Pneumococcal Vaccination in Crohn's Disease: A Prospective Multicenter Study Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
30 A Randomized Controlled Trial Investigating Tailored Treatment With Infliximab for Active Luminal Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
31 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
32 An Open-Label, Multicenter and Open Enrollment Model, Postmarketing, Milk-Only Lactation Study to Assess Concentration of Vedolizumab in Breast Milk of Lactating Women With Active Ulcerative Colitis or Crohn's Disease Who Are Receiving Vedolizumab Therapeutically Completed NCT02559713 Phase 4 Vedolizumab
33 The Ideal Management of Crohn's Disease: Top Down Versus Step Up Strategies. A Prospective Controlled Trial in the Benelux Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
34 A Randomized, Data Collection Program To Determine the Efficacy and Safety of Risedronate (Actonel) Therapy Plus Calcium and Vitamin D Supplementation Versus Placebo Plus Calcium and Vitamin D Supplementation in the Treatment of Low Bone Mineral Density in Crohn's Disease Patients Completed NCT01215890 Phase 4 risedronate;placebo
35 Multicentre, Controlled, Randomised, Open, Cross-over Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tbl. 500 mg in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
36 Microarray Analysis of Peripheral Blood and Tissues of Patients With Immune Mediated Inflammatory Diseases Completed NCT00462072 Phase 4 Infliximab
37 Modulation of Immune Function by Parenteral Fish Oil in Patients With Crohn's Disease and High Inherent Tumor Necrosis Factor-alpha Production: a Randomized, Single Blinded, Cross-over Study Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
38 A Randomized Double-Blind Phase 4 Study to Evaluate the Safety and Proportion of Subjects With Fistula Healing in 2 Dose Regimens of Entyvio (Vedolizumab IV) in the Treatment of Fistulizing Crohn's Disease (ENTERPRISE) Completed NCT02630966 Phase 4 Vedolizumab;Placebo
39 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy (the ICE Study) Completed NCT01181765 Phase 4
40 Comparison of Immune Response to the Human Papillomavirus Vaccine in Young Women With and Without Inflammatory Bowel Disease Completed NCT01034358 Phase 4
41 A Cluster Randomized Controlled Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
42 A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL) Completed NCT01804166 Phase 4 Infliximab;Golimumab
43 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease: a Placebo-controlled Randomized Trial Completed NCT02010762 Phase 4 Vitamin D;Placebo
44 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease: A Prospective, Randomized, Double-Blind, Controlled Trial Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
45 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
46 Prospective Comparison of VoLumen and Breeza Oral Contrast Agents in Pediatric Patients Undergoing CT and MR Enterography Completed NCT02946203 Phase 4
47 Influence of Immunosuppressive Treatment on Immunological Response to Pneumococcal Conjugated Vaccine (PCV13) in Patients With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
48 Pneumococcal Vaccination of Crohn Patients - A Randomized, Non-blinded Phase 4 Clinical Trial With the Purpose of Investigating the Immune Response Against Two Different Pneumococcal Vaccines in Patients With Crohn's Disease Completed NCT01947010 Phase 4
49 Phase 4, Open Lable Non Randomized un Controlled Study. Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation Completed NCT02269358 Phase 4 METHOTREXATE
50 Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


aminosalicylic acid
Azathioprine
Cholecalciferol
natalizumab
Opium
OPIUM ALKALOIDS HYDROCHLORIDE
OPIUM, POWDERED
paregoric
Thalidomide

Cochrane evidence based reviews: crohn disease

Genetic Tests for Crohn's Colitis

Anatomical Context for Crohn's Colitis

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Colitis:

19
Colon Only

MalaCards organs/tissues related to Crohn's Colitis:

40
Colon, Bone, T Cells, Testes, Small Intestine, Skin, Liver

Publications for Crohn's Colitis

Articles related to Crohn's Colitis:

(show top 50) (show all 4789)
# Title Authors PMID Year
1
Long-term Results of the Side-to-side Isoperistaltic Strictureplasty in Crohn Disease: 25-year Follow-up and Outcomes. 61
30720502 2020
2
Emerging Roles of PET/MR in the Pediatric Hospital. 61
32498981 2020
3
The Safety and Feasibility of a New Through-the-scope Balloon-assisted Enteroscopy in Children. 61
32187142 2020
4
A case-control study of HLA alleles in Brazilian patients with Melkersson-Rosenthal syndrome. 61
32045706 2020
5
Body Composition Using Air Displacement Plethysmography in Children With Inflammatory Bowel Disease. 61
32141991 2020
6
Extraintestinal Manifestations Are Associated With Disease Severity in Pediatric Onset Inflammatory Bowel Disease. 61
32187141 2020
7
Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications. 61
32236745 2020
8
Patterns of Primary, Specialty, Urgent Care, and Emergency Department Care in Children With Inflammatory Bowel Diseases. 61
32142000 2020
9
Azathioprine-Induced Tremor: A Rare, Dose-Dependent Side Effect of Azathioprine in a Patient With Active Crohn Disease. 61
32444877 2020
10
Association Between Steroid-Sparing Therapy and the Risk of Perianal Fistulizing Complications Among Young Patients With Crohn Disease. 61
32515798 2020
11
A retrospective study on efficacy of the ERAS protocol in patients undergoing surgery for Crohn disease: A propensity score analysis. 61
32085992 2020
12
Effect of Exclusive Enteral Nutrition on Renal Function for Granulomatous Interstitial Nephritis Associated With Crohn Disease. 61
32566946 2020
13
Smoking Cessation for Patients With Crohn Disease: Not Just for the Patient? 61
32529237 2020
14
Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease. 61
32273172 2020
15
Increased Postoperative Use of Computed Tomography Following Emergency Surgery for Ileocaecal Crohn Disease. 61
32150121 2020
16
The Efficacy of BurstDR Spinal Cord Stimulation for Chronic Abdominal Pain: A Clinical Series. 61
32105875 2020
17
Relationship between selenium status and biomarkers of oxidative stress in Crohn's disease. 61
32244179 2020
18
Prevalence and clinical significance of incidental extra-intestinal findings in MR enterography: experience of a single University Centre. 61
32495273 2020
19
Corrigendum to The Cost of Inflammatory Bowel Disease: An Initiative From the Crohn's & Colitis Foundation. 61
32374862 2020
20
Exceptional Paraspinal Localization of Myositis in a Patient With Crohn Disease Under Tumor Necrosis Factor α Inhibitor Treatment: A Case Report. 61
32496360 2020
21
Role of Thiopurines in Pediatric Inflammatory Bowel Diseases: A Real-Life Prospective Cohort Study. 61
32443042 2020
22
Targeting epithelium-expressed sialyl Lewis glycans improves colonic mucosal wound healing and protects against colitis. 61
32427587 2020
23
Ultrasonographic and clinical assessment of peripheral enthesitis and arthritis in an Italian cohort of inflammatory bowel disease patients. 61
32061429 2020
24
The risk of rheumatoid arthritis among patients with inflammatory bowel disease: a systematic review and meta-analysis. 61
32552882 2020
25
Dose Escalation Assessment Among Targeted Immunomodulators in the Management of Inflammatory Bowel Disease. 61
32191593 2020
26
Profiling of Human Circulating Dendritic Cells and Monocyte Subsets Discriminates Between Type and Mucosal Status in Patients With Inflammatory Bowel Disease. 61
32548643 2020
27
Faecal calprotectin in dermatology practice. 61
32578256 2020
28
Redo IPAA After a Failed Pouch In Patients With Crohn's Disease: Is It Worth Trying? 61
32384407 2020
29
New Presentation of Hepatic Inflammatory Pseudotumor and Crohn Disease. 61
32561902 2020
30
Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis. 61
32552311 2020
31
Hidradenitis Suppurativa and Crohn Disease: A Rare Association. 61
32304573 2020
32
Amoebic Liver Abscess in Crohn Disease Treated With Ustekinumab. 61
32405649 2020
33
A pilot feasibility study of non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory Crohn Disease. 61
32467584 2020
34
Trends of 5-Aminosalicylate Medication Use in Patients With Crohn Disease. 61
32469067 2020
35
Trichosporon montevideense isolated from the descending colon of a patient with active severe Crohn disease: a case report. 61
32433059 2020
36
CpG Methylation in TGFβ1 and IL-6 Genes as Surrogate Biomarkers for Diagnosis of IBD in Children. 61
32407484 2020
37
Prevalence of irritable bowel syndrome-like symptoms using Rome IV criteria in patients with inactive inflammatory bowel disease and relation with quality of life. 61
32384473 2020
38
Modified Van Assche magnetic resonance imaging-based score for assessing the clinical status of anal fistulas. 61
32384475 2020
39
Beyond Crohn Disease: Current Role of Radiologists in Diagnostic Imaging Assessment of Inflammatory Bowel Disease Transitioning from Pediatric to Adult Patients. 61
32276701 2020
40
Gastrointestinal involvement of primary skin diseases. 61
32455473 2020
41
Association Between Tumor Necrosis Factor Inhibitor Exposure and Inflammatory Central Nervous System Events. 61
32421186 2020
42
The Role of Citrullination in Inflammatory Bowel Disease: A Neglected Player in Triggering Inflammation and Fibrosis? 61
32426830 2020
43
Eosinophilic Esophagitis. 61
32365374 2020
44
Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria. 61
32469069 2020
45
Fecal Markers of Inflammation and Disease Activity in Pediatric Crohn Disease: Results from the ImageKids Study. 61
31899733 2020
46
Identification and diagnosis of Crohn disease and ulcerative colitis in children. 61
32468706 2020
47
Systematic Review: Psychosocial Correlates of Pain in Pediatric Inflammatory Bowel Disease. 61
32458966 2020
48
Black and White Patients With Inflammatory Bowel Disease Show Similar Biologic Use Patterns With Medicaid Insurance. 61
32405642 2020
49
Effect of Abdominal Lymphatic Pump Treatment on Disease Activity in a Rat Model of Inflammatory Bowel Disease. 61
32337567 2020
50
Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002-2017). 61
32058417 2020

Variations for Crohn's Colitis

Expression for Crohn's Colitis

Search GEO for disease gene expression data for Crohn's Colitis.

Pathways for Crohn's Colitis

Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TNF NOS2 NOD2 IL2 IL1B IFNG
2
Show member pathways
13.35 TNF NOS2 NOD2 IL2 IL1B IFNG
3
Show member pathways
13.05 TNF NOS2 IL2 IL1B IFNG CXCL8
4
Show member pathways
12.85 TNF IL2 IL1B IFNG CXCL8
5 12.83 NOS2 IL2 IFNG CXCL8 CDH1
6
Show member pathways
12.81 TNF IL2 IL1B IFNG CXCL8
7
Show member pathways
12.72 TNF NOS2 NOD2 IL1B CXCL8
8
Show member pathways
12.59 TNF NOD2 IL2 IL1B IFNG
9
Show member pathways
12.58 TNF NOS2 IL2 IL1B IFNG
10 12.39 TNF IL1B CXCL8 ATG16L1
11
Show member pathways
12.33 TNF IL2 CXCL8 CCR6
12
Show member pathways
12.33 TNF IL2 IL1B IFNG
13
Show member pathways
12.29 TNF NOS2 IL1B IFNG CXCL8
14
Show member pathways
12.29 TNF IL1B IFNG DEFB4A CXCL8
15
Show member pathways
12.26 TNF NOS2 IL1B IFNG
16
Show member pathways
12.26 TNF IL2 IL1B IFNG CXCL8
17 12.18 TNF NOS2 IFNG CDH1
18 12.16 TNF NOS2 NOD2 IL1B IFNG
19 12.12 TNF MIR598 MIR29A IL1B
20 11.99 TNF IL2 IL1B CXCL8
21 11.96 TNF NOS2 IL1B CXCL8
22 11.96 TNF NOD2 IL1B DEFB4A DEFA5 CXCL8
23
Show member pathways
11.95 NOS2 IL2 IL1B IFNG
24
Show member pathways
11.95 TNF NOS2 IL1B IFNG DEFB4A CXCL8
25 11.91 IL1B IFNG CXCL8 ATG16L1
26
Show member pathways
11.9 TNF IL2 IL1B IFNG
27 11.84 TNF IL1B IFNG CXCL8
28 11.84 TNF NOS2 IL1B IFNG CXCL8
29 11.79 IL2 IFNG CXCL8
30 11.72 TNF NOS2 IL1B CXCL8
31
Show member pathways
11.71 TNF IL2 IFNG CXCL8
32 11.67 TNF IL2 IL1B IFNG CCR6
33 11.66 TNF IL1B CXCL8
34
Show member pathways
11.64 TNF IL2 IFNG
35 11.61 TNF IL1B CXCL8
36 11.59 NOS2 IFNG CXCL8
37 11.59 TNF IL2 IL1B IFNG CDH1
38 11.55 TNF IL2 IFNG
39 11.53 TNF IL1B CXCL8
40 11.49 TNF IL1B IFNG
41 11.49 TNF IL1B IFNG CXCL8
42 11.46 TNF NOS2 IL1B IFNG
43 11.44 TNF IL2 IL1B IFNG
44 11.38 NOS2 IL1B IFNG
45 11.38 TNF IL1B IFNG
46
Show member pathways
11.36 TNF IL2 IFNG
47 11.3 TNF IL1B IFNG
48 11.25 TNF SLIT2 NOS2 IL2 IL1B IFNG
49
Show member pathways
11.23 TNF NOS2 IL2 IL1B IFNG CXCL8
50 11.17 TNF IL2 IL1B IFNG

GO Terms for Crohn's Colitis

Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TNF TMEFF2 SLIT2 IL2 IL1B IFNG
2 extracellular space GO:0005615 9.32 TNF SLIT2 MIR29A MIR103A2 IL2 IL1B

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.06 TNF MIR29A IL1B IFNG CDH3
2 cytokine-mediated signaling pathway GO:0019221 9.93 TNF NOS2 IL2 IL1B CXCL8
3 positive regulation of protein phosphorylation GO:0001934 9.92 TNF IL2 IL1B IFNG
4 chemotaxis GO:0006935 9.91 SLIT2 DEFB4A CXCL8 CCR6
5 defense response to bacterium GO:0042742 9.91 TNF NOS2 NOD2 DEFB4A DEFA5
6 negative regulation of cell migration GO:0030336 9.88 TMEFF2 SLIT2 MIR29A CDH1
7 positive regulation of JNK cascade GO:0046330 9.84 TNF NOD2 IL1B
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 TNF IL2 IFNG
9 cellular response to organic cyclic compound GO:0071407 9.82 TNF NOD2 IL1B
10 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.82 DEFB4A DEFA5 CXCL8
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TNF NOD2 IL1B
12 humoral immune response GO:0006959 9.8 TNF IFNG CCR6
13 positive regulation of interleukin-6 production GO:0032755 9.79 TNF NOD2 IL1B
14 positive regulation of phagocytosis GO:0050766 9.77 TNF IL1B IFNG
15 positive regulation of interferon-gamma production GO:0032729 9.76 TNF IL2 IL1B
16 positive regulation of inflammatory response GO:0050729 9.76 TNF IL2 IL1B IFNG
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 TNF IL1B IFNG
18 positive regulation of interleukin-6 secretion GO:2000778 9.73 TNF IL1B IFNG
19 regulation of insulin secretion GO:0050796 9.71 TNF NOS2 IL1B IFNG
20 positive regulation of interleukin-8 production GO:0032757 9.7 TNF NOD2 IL1B
21 immune response GO:0006955 9.7 TNF IL2 IL1B IFNG DEFB4A CXCL8
22 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL1B
23 negative regulation of amyloid-beta clearance GO:1900222 9.66 TNF IFNG
24 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.65 TNF IFNG
25 defense response GO:0006952 9.65 TNF NOD2 DEFB4A DEFA5 CXCL8
26 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
27 positive regulation of killing of cells of other organism GO:0051712 9.61 NOS2 IFNG
28 astrocyte activation GO:0048143 9.61 TNF IL1B IFNG
29 positive regulation of fever generation GO:0031622 9.6 TNF IL1B
30 sequestering of triglyceride GO:0030730 9.55 TNF IL1B
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 TNF IL1B IFNG
32 positive regulation of chemokine biosynthetic process GO:0045080 9.5 TNF IL1B IFNG
33 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 TNF IFNG
34 positive regulation of nitrogen compound metabolic process GO:0051173 9.48 TNF IFNG
35 cellular response to lipopolysaccharide GO:0071222 9.43 TNF NOS2 NOD2 IL1B DEFA5 CXCL8
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL2 IL1B IFNG CXCL8

Sources for Crohn's Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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