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MCID: CRH001
MIFTS: 78

Crohn's Disease

Categories: Rare diseases, Gastrointestinal diseases, Infectious diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Crohn's Disease

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MalaCards integrated aliases for Crohn's Disease:

Name: Crohn's Disease 38 12 76 53 25 37 43 15
Crohn Disease 12 25 6 73
Pediatric Crohn's Disease 12 53 73
Enteritis 53 55 73
Crohn's Disease of Large Bowel 12 73
Granulomatous Colitis 12 53
Ileitis 53 73
Pediatric Onset Crohn's Disease 53
Crohn's Disease, Pediatric 53
Crohn's Disease of Colon 12
Enteritis, Granulomatous 25
Granulomatous Enteritis 53
Colitis, Granulomatous 25
Enteritis, Regional 25
Regional Enteritis 73
Crohn's Enteritis 25

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Crohn's Disease

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NIH Rare Diseases : 53 Crohn's disease is a type of inflammatory bowel disease (IBD), the general name for conditions that cause inflammation in the gastrointestinal (GI) tract. Common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. Other general symptoms include feeling tired, nausea and loss of appetite, fever, and anemia. Complications of Crohn's disease may include intestinal blockage, fistulas, anal fissures, ulcers, malnutrition, and inflammation in other areas of the body. Crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. The exact cause is unknown, but is thought to be due from a combination of certain genetic variations, changes in the immune system, and the presence of bacteria in the digestive tract.  Many of the major genes related to Crohn disease, including NOD2, ATG16L1, IL23R, and IRGM, are involved in immune system function. The disease is not inherited but it appears to run in some families because in about 15% of the cases the disease is present in more than one relative.  Treatment is aimed at relieving symptoms and reducing inflammation, and may include diet and medication, but some people require surgery. Surgery often involves removal of the diseased segment of bowel (resection), the two ends of healthy bowel are then joined together (anastomosis). In about 30% of people who have surgery for Crohn’s disease symptoms may come back within three years and up to 60% will have recurrence within ten years.

MalaCards based summary : Crohn's Disease, also known as crohn disease, is related to inflammatory bowel disease 1 and inflammatory bowel disease 25, autosomal recessive, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Crohn's Disease is ENSG00000278769 (
LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Cytokine-cytokine receptor interaction. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are hematopoietic system and digestive/alimentary

MedlinePlus : 43 Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory bowel disease. Crohn's can affect any area from the mouth to the anus. It often affects the lower part of the small intestine called the ileum. The cause of Crohn's disease is unknown. It may be due to an abnormal reaction by the body's immune system. It also seems to run in some families. It most commonly starts between the ages of 13 and 30. The most common symptoms are pain in the abdomen and diarrhea. Other symptoms include Bleeding from the rectum Weight loss Fever Your doctor will diagnose Crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. Crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. People with Crohn's can also have joint pain and skin problems. Children with the disease may have growth problems. There is no cure for Crohn's. Treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. Some people have long periods of remission, when they are free of symptoms. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Genetics Home Reference : 25 Crohn disease is a complex, long-lasting (chronic) disorder that primarily affects the digestive system. This condition involves an abnormal immune response that causes excess inflammation. It most often affects the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). However, inflammation can occur in any part of the digestive system, from the mouth to the anus. The inflamed tissues become thick and swollen, and the inner surfaces of the digestive system may develop open sores (ulcers).

Disease Ontology : 12 An intestinal disease that involves inflammation located in intestine.

Wikipedia : 76 Crohn\'s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

Sources

Related Diseases for Crohn's Disease

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Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 1 33.7 NOD2 SLC22A4 SLC22A5
2 inflammatory bowel disease 25, autosomal recessive 32.4 IL10RA IL10RB
3 ulcerative colitis 30.2 ABCB1 ATG16L1 IL10RA IL10RB IL23R IRGM
4 colitis 29.6 ABCB1 ATG16L1 DUOX2 IL10RA IL10RB IL23R
5 inflammatory bowel disease 27.1 ABCB1 ATG16L1 DUOX2 IL10RA IL10RB IL12RB2
6 ileitis 12.5
7 thoraco abdominal enteric duplication 12.2
8 cryptogenic multifocal ulcerous stenosing enteritis 12.0
9 enteric pattern testicular yolk sac tumor 11.9
10 trichohepatoenteric syndrome 1 11.7
11 crohn's colitis 11.4
12 thiopurines, poor metabolism of, 1 11.1
13 hermansky-pudlak syndrome 4 11.0
14 hermansky-pudlak syndrome 5 11.0
15 inflammatory bowel disease 10 10.9
16 inflammatory bowel disease 13 10.9
17 inflammatory bowel disease 14 10.9
18 inflammatory bowel disease 17 10.9
19 inflammatory bowel disease 19 10.9
20 inflammatory bowel disease 28, autosomal recessive 10.9
21 bile acid malabsorption, primary 10.8
22 autoimmune disease 6 10.8
23 short bowel syndrome 10.8
24 intestinal disease 10.6 ATG16L1 IL23R IRGM NOD2
25 inflammatory bowel disease 5 10.5 ATG16L1 IL23R NOD2 SLC22A4 SLC22A5
26 ovarian mucinous adenocarcinoma 10.4 ABCB1 MUC2
27 leprosy 3 10.4 IL12RB2 LACC1 NOD2 SLC11A1
28 sarcoidosis 1 10.4 IL12RB2 NOD2 SLC11A1
29 multidrug-resistant tuberculosis 10.2 ABCB1 SLC11A1
30 pouchitis 10.1
31 purpura 10.0
32 mesenteric lymphadenitis 9.9
33 lymphadenitis 9.9
34 gastritis 9.8
35 anisakiasis 9.8
36 appendicitis 9.8
37 breast cancer 9.7
38 intussusception 9.7
39 fabry disease 9.7
40 cholangitis, primary sclerosing 9.7
41 glomerulonephritis 9.7
42 intestinal schistosomiasis 9.7
43 lymphoma 9.7
44 collagenous colitis 9.7
45 ileocolitis 9.7
46 thrombosis 9.7
47 protein-losing enteropathy 9.7
48 salpingo-oophoritis 9.7
49 henoch-schoenlein purpura 9.7
50 typhoid fever 9.7

Comorbidity relations with Crohn's Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Inflammatory Bowel Disease 1
Intestinal Obstruction Protein-Energy Malnutrition
Ulcerative Colitis

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to Crohn's Disease
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Symptoms & Phenotypes for Crohn's Disease

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UMLS symptoms related to Crohn's Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 IRF5 ABCB1 ITGA4 LACC1 ATG16L1 MUC2
2 digestive/alimentary MP:0005381 9.96 ABCB1 ATG16L1 MUC2 NOD2 IL10RA SLC11A1
3 homeostasis/metabolism MP:0005376 9.8 IL23R IRF5 ABCB1 LACC1 ATG16L1 DUOX2
4 immune system MP:0005387 9.47 IRF5 ABCB1 ITGA4 ATG16L1 LACC1 MUC2
Sources

Drugs & Therapeutics for Crohn's Disease

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Drugs for Crohn's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 422)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
2
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
3
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
5
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
6
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
7
Rifabutin Approved, Investigational Phase 4,Phase 3 72559-06-9 6323490
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
10
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
11
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
12
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
13
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
14 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 943609-66-3
15
Azithromycin Approved Phase 4 83905-01-5 55185 447043
16
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
17
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
18
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
19
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
20
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
21
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
22
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
23
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
24
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
25
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
26
Everolimus Approved Phase 4 159351-69-6 6442177
27
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
28
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
29
Dextromethorphan Approved Phase 4,Phase 1 125-71-3 5360696 5362449
30
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 93-14-1 3516
31
Losartan Approved Phase 4 114798-26-4 3961
32
Thioguanine Approved Phase 4 154-42-7 2723601
33
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 564-25-0 54671203
34
Vancomycin Approved Phase 4,Phase 2 1404-90-6 441141 14969
35
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
36
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
37
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-14-6 5280793
39 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1406-16-2
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
42
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 67-97-0 6221 5280795
43
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 143 6006
44
Menadione Approved, Nutraceutical Phase 4,Phase 1 58-27-5 4055
45
Phytonadione Approved, Investigational, Nutraceutical Phase 4,Phase 1 84-80-0 4812 5284607
46
Caffeine Approved, Nutraceutical Phase 4,Phase 1 58-08-2 2519
47 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1184)
# Name Status NCT ID Phase Drugs
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
5 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
6 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
7 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
8 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
9 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
12 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
13 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
14 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
15 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
16 Prucalopride Prior to Small Bowel Capsule Endoscopy Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
17 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
18 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
19 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
20 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
21 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
22 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
23 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
24 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
25 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
26 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
27 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
28 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
29 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
30 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
31 Vitamin D Supplementation in Adult Crohn's Disease Completed NCT01369667 Phase 4
32 Adalimumab-psoriasis and Small Bowel Lesions Completed NCT01556672 Phase 4 Adalimumab
33 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4 risedronate;placebo
34 Early Immunosuppressants in Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
35 Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Completed NCT00280956 Phase 4 natalizumab
36 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
37 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
38 The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Completed NCT01235325 Phase 4
39 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
40 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
41 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
42 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
43 Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
44 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
45 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4 Infliximab
46 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
47 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
48 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
49 Immunogenicity of Hepatitis A Vaccine in Inflammatory Bowel Disease (IBD) Patients Completed NCT01341808 Phase 4
50 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab

Search NIH Clinical Center for Crohn's Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Crohn's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Crohn's Disease:
Bone marow-derived mesenchymal stem cells for the treatment of Crohn's disease
Hematopoietic stem cell transplantation for Crohn's disease
Hematopoietic stem cells for severe Crohn's disease
Ovasave
PDA001, Placenta-derived cells for Crohn's disease
Periperal blood-derived CD34+ stem cells for treatment of Crohn's disease
Prochymal
Regenerative ColoTherapy
Embryonic/Adult Cultured Cells Related to Crohn's Disease:
Bone marrow-derived mesenchymal stem cell
Peripheral blood-derived hematopoietic stem cells (family) PMIDs: 15549303
Ovalbumin speci?c type 1 regulatory T- cells (Ovasave PMIDs: 22885333 19539556
Placenta-derived cells PMIDs: 23429460
Bone marrow-derived mesenchymal stem cells PMIDs: 19530993 21787241
Adipose-derived mesenchymal stem cells (family)
Sources

Genetic Tests for Crohn's Disease

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Sources

Anatomical Context for Crohn's Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Disease:

19
Intestine

MalaCards organs/tissues related to Crohn's Disease:

41
Colon, Bone, T Cells, Testes, Skin, Small Intestine, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
Sources

Publications for Crohn's Disease

About this section

Articles related to Crohn's Disease:

(show top 50) (show all 4133)
# Title Authors Year
1
Paradoxical pustular psoriasis induced by ustekinumab in a patient with Crohn's disease-associated spondyloarthropathy. ( 29705819 )
2018
2
Optimized thiopurine therapy before withdrawal of anti-tumour necrosis factor-I+ in patients with Crohn's disease. ( 29975242 )
2018
3
Colonic perforation due to GI histoplasmosis in an immunocompetent host mimicking Crohn's disease. ( 29337040 )
2018
4
Does a histologically inflamed resection margin increase postoperative complications in patients with Crohn's disease? ( 29431516 )
2018
5
Anti-infliximab antibody concentrations can guide treatment intensification in patients with Crohn's disease who lose clinical response. ( 29226370 )
2018
6
Intestinal paracoccidioidomycosis resembling Crohn's disease in a teenager: a case report. ( 29706133 )
2018
7
Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease-when to look for it? ( 29446132 )
2018
8
Endoscopic valvectomy of ileocecal valve stricture resulting in resolution of ileitis in Crohn's disease. ( 29476842 )
2018
9
Filgotinib for the treatment of Crohn's disease. ( 29448862 )
2018
10
The state of the art on treatment of Crohn's disease. ( 29980848 )
2018
11
Infliximab-Induced Tubulointerstitial Nephritis with Image Findings of Striated Nephrogram in Crohn's Disease. ( 29973427 )
2018
12
Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians. ( 29960072 )
2018
13
Endospore forming bacteria may be associated with maintenance of surgically-induced remission in Crohn's disease. ( 29950676 )
2018
14
Assessment of factors associated with smoking cessation at diagnosis or during follow-up of Crohn's disease. ( 28556205 )
2018
15
Paracoccidioidomycosis simulating Crohn's disease. ( 29746902 )
2018
16
IgG4-Related Disease Mimicking Crohn's Disease: A Case Report and Review of Literature. ( 29417330 )
2018
17
Gastrointestinal Diaphragm Disease With Retained Capsule Endoscope, Associated With Crohn's Disease: A Case Report. ( 29890901 )
2018
18
Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence. ( 29434453 )
2018
19
[X-linked inhibitor of apoptosis deficiency manifested as Crohn's disease: a case report and literature review]. ( 29342997 )
2018
20
Utility of proactive infliximab levels in paediatric Crohn's disease. ( 29950353 )
2018
21
Diagnostic dilemma: think about anterior cutaneous nerve entrapment syndrome (ACNES) in patients with atypical abdominal pain and Crohn's disease. ( 29593000 )
2018
22
What Is the Risk of Progressive Multifocal Leukoencephalopathy in Patients With Ulcerative Colitis or Crohn's Disease Treated With Vedolizumab? ( 29668955 )
2018
23
Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. ( 29434451 )
2018
24
Persistent neutrophilic scarring alopecia triggered by anti-TNF blockade for Crohn's disease. ( 29976546 )
2018
25
Crohn's Disease in Niemann-Pick Disease Type C1: Caught in the Cross-Fire of Host-Microbial Interactions. ( 29411209 )
2018
26
A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population. ( 29441677 )
2018
27
Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy. ( 29890558 )
2018
28
High Incidence of Recurrent Crohn's Disease Following Colectomy for Ulcerative Colitis Revealed with Long Follow-Up. ( 29282640 )
2018
29
Postoperative therapy with infliximab for Crohn's disease: a 2-year prospective randomized multicenter study in Japan. ( 29383596 )
2018
30
Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn's disease. ( 29129496 )
2018
31
Prognostic value of preoperative neutrophil-to-lymphocyte ratio in Crohn's disease. ( 29435759 )
2018
32
Isolated Terminal Ileitis: When Is It Not Crohn's Disease? ( 29536222 )
2018
33
Ileum Histoplasmosis Mimicking Intestinal Tuberculosis and Crohn's Disease. ( 29515346 )
2018
34
Cutaneous manifestations of metastatic Crohn's disease. ( 29952016 )
2018
35
Budd-Chiari syndrome: a rare and life-threatening complication of Crohn's disease. ( 29348288 )
2018
36
Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease. ( 29961815 )
2018
37
SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn's Disease with Significant Inverse Correlation to Disease Activity. ( 29977289 )
2018
38
Developing a core outcome set for fistulising perianal Crohn's disease. ( 29437911 )
2018
39
A Challenging Case of Retroperitoneal Abscess in a Post-Partum Crohn's Disease Patient. ( 29961750 )
2018
40
Diagnostic Performance of a 5-Marker Predictive Model for Differential Diagnosis Between Intestinal Tuberculosis and Crohn's Disease. ( 29860270 )
2018
41
Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease-when to look for it? Authors' reply. ( 29446137 )
2018
42
Superior Mesenteric Artery Syndrome in Patients with Crohn's Disease: A Description of 2 Cases Studied with a Novel Magnetic Resonance Enterography (MRE) Procedure. ( 29643328 )
2018
43
Crohn's disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan. ( 29948302 )
2018
44
Pulmonary strongyloidiasis causing septic shock in a patient with Crohn's disease. ( 29977759 )
2018
45
Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease. ( 29951563 )
2018
46
Histologic features in pediatric ileitis: Is it possible to tip the balance towards Crohn's disease? ( 29397324 )
2018
47
Dissecting Cellulitis of the Scalp: A Rare Dermatological Manifestation of Crohn's Disease. ( 29430467 )
2018
48
A BACH2 Gene Variant Is Associated with Postoperative Recurrence of Crohn's Disease. ( 29452228 )
2018
49
Comparison of infliximab with adalimumab in 827 biologic-naA^ve patients with Crohn's disease: a population-based Danish cohort study. ( 29239001 )
2018
50
Crohn's Disease Candidate Gene Alleles Predict Time to Progression from Inflammatory B1 to Stricturing B2, or Penetrating B3 Phenotype. ( 29446656 )
2018
Sources

Variations for Crohn's Disease

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ClinVar genetic disease variations for Crohn's Disease:

6
(show top 50) (show all 160)
# Gene Variation Type Significance SNP ID Assembly Location
1 NOD2 NM_022162.2(NOD2): c.3019dupC (p.Leu1007Profs) duplication risk factor rs2066847 GRCh38 Chromosome 16, 50729870: 50729870
2 NOD2 NM_022162.2(NOD2): c.3019dupC (p.Leu1007Profs) duplication risk factor rs2066847 GRCh37 Chromosome 16, 50763781: 50763781
3 NOD2 NM_022162.2(NOD2): c.2722G> C (p.Gly908Arg) single nucleotide variant risk factor rs2066845 GRCh37 Chromosome 16, 50756540: 50756540
4 NOD2 NM_022162.2(NOD2): c.2722G> C (p.Gly908Arg) single nucleotide variant risk factor rs2066845 GRCh38 Chromosome 16, 50722629: 50722629
5 NOD2 NM_022162.2(NOD2): c.2104C> T (p.Arg702Trp) single nucleotide variant risk factor rs2066844 GRCh37 Chromosome 16, 50745926: 50745926
6 NOD2 NM_022162.2(NOD2): c.2104C> T (p.Arg702Trp) single nucleotide variant risk factor rs2066844 GRCh38 Chromosome 16, 50712015: 50712015
7 NOD2 NM_022162.2(NOD2): c.2555A> G (p.Asn852Ser) single nucleotide variant risk factor rs104895467 GRCh37 Chromosome 16, 50750810: 50750810
8 NOD2 NM_022162.2(NOD2): c.2555A> G (p.Asn852Ser) single nucleotide variant risk factor rs104895467 GRCh38 Chromosome 16, 50716899: 50716899
9 NOD2 NM_022162.2(NOD2): c.2107C> T (p.Arg703Cys) single nucleotide variant Likely benign rs5743277 GRCh37 Chromosome 16, 50745929: 50745929
10 NOD2 NM_022162.2(NOD2): c.2107C> T (p.Arg703Cys) single nucleotide variant Likely benign rs5743277 GRCh38 Chromosome 16, 50712018: 50712018
11 NOD2 NM_022162.2(NOD2): c.-59G> A single nucleotide variant Benign rs2076752 GRCh38 Chromosome 16, 50697185: 50697185
12 NOD2 NM_022162.2(NOD2): c.-59G> A single nucleotide variant Benign rs2076752 GRCh37 Chromosome 16, 50731096: 50731096
13 NOD2 NM_022162.2(NOD2): c.484G> A (p.Val162Ile) single nucleotide variant Likely benign rs139571975 GRCh38 Chromosome 16, 50699898: 50699898
14 NOD2 NM_022162.2(NOD2): c.484G> A (p.Val162Ile) single nucleotide variant Likely benign rs139571975 GRCh37 Chromosome 16, 50733809: 50733809
15 NOD2 NM_022162.2(NOD2): c.633C> T (p.Ala211=) single nucleotide variant Likely benign rs5743269 GRCh38 Chromosome 16, 50707947: 50707947
16 NOD2 NM_022162.2(NOD2): c.633C> T (p.Ala211=) single nucleotide variant Likely benign rs5743269 GRCh37 Chromosome 16, 50741858: 50741858
17 NOD2 NM_022162.2(NOD2): c.807G> A (p.Pro269=) single nucleotide variant Uncertain significance rs369766454 GRCh37 Chromosome 16, 50744629: 50744629
18 NOD2 NM_022162.2(NOD2): c.807G> A (p.Pro269=) single nucleotide variant Uncertain significance rs369766454 GRCh38 Chromosome 16, 50710718: 50710718
19 NOD2 NM_022162.2(NOD2): c.1981G> C (p.Ala661Pro) single nucleotide variant Uncertain significance rs369957746 GRCh38 Chromosome 16, 50711892: 50711892
20 NOD2 NM_022162.2(NOD2): c.1981G> C (p.Ala661Pro) single nucleotide variant Uncertain significance rs369957746 GRCh37 Chromosome 16, 50745803: 50745803
21 NOD2 NM_022162.2(NOD2): c.2489G> A (p.Arg830Gln) single nucleotide variant Uncertain significance rs770915641 GRCh38 Chromosome 16, 50716613: 50716613
22 NOD2 NM_022162.2(NOD2): c.2489G> A (p.Arg830Gln) single nucleotide variant Uncertain significance rs770915641 GRCh37 Chromosome 16, 50750524: 50750524
23 NOD2 NM_022162.2(NOD2): c.*325G> A single nucleotide variant Uncertain significance rs886052046 GRCh38 Chromosome 16, 50732144: 50732144
24 NOD2 NM_022162.2(NOD2): c.*325G> A single nucleotide variant Uncertain significance rs886052046 GRCh37 Chromosome 16, 50766055: 50766055
25 NOD2 NM_022162.2(NOD2): c.*394C> T single nucleotide variant Uncertain significance rs886052048 GRCh37 Chromosome 16, 50766124: 50766124
26 NOD2 NM_022162.2(NOD2): c.*394C> T single nucleotide variant Uncertain significance rs886052048 GRCh38 Chromosome 16, 50732213: 50732213
27 NOD2 NM_022162.2(NOD2): c.*397A> C single nucleotide variant Benign rs3135499 GRCh37 Chromosome 16, 50766127: 50766127
28 NOD2 NM_022162.2(NOD2): c.*397A> C single nucleotide variant Benign rs3135499 GRCh38 Chromosome 16, 50732216: 50732216
29 NOD2 NM_022162.2(NOD2): c.*462C> A single nucleotide variant Uncertain significance rs562972090 GRCh37 Chromosome 16, 50766192: 50766192
30 NOD2 NM_022162.2(NOD2): c.*462C> A single nucleotide variant Uncertain significance rs562972090 GRCh38 Chromosome 16, 50732281: 50732281
31 NOD2 NM_022162.2(NOD2): c.*620G> A single nucleotide variant Likely benign rs116213743 GRCh37 Chromosome 16, 50766350: 50766350
32 NOD2 NM_022162.2(NOD2): c.*620G> A single nucleotide variant Likely benign rs116213743 GRCh38 Chromosome 16, 50732439: 50732439
33 NOD2 NM_022162.2(NOD2): c.-53C> T single nucleotide variant Likely benign rs188341692 GRCh38 Chromosome 16, 50697191: 50697191
34 NOD2 NM_022162.2(NOD2): c.-53C> T single nucleotide variant Likely benign rs188341692 GRCh37 Chromosome 16, 50731102: 50731102
35 NOD2 NM_022162.2(NOD2): c.-14C> T single nucleotide variant Likely benign rs117611225 GRCh37 Chromosome 16, 50731141: 50731141
36 NOD2 NM_022162.2(NOD2): c.-14C> T single nucleotide variant Likely benign rs117611225 GRCh38 Chromosome 16, 50697230: 50697230
37 NOD2 NM_022162.2(NOD2): c.52G> A (p.Val18Ile) single nucleotide variant Uncertain significance rs886052043 GRCh38 Chromosome 16, 50697295: 50697295
38 NOD2 NM_022162.2(NOD2): c.52G> A (p.Val18Ile) single nucleotide variant Uncertain significance rs886052043 GRCh37 Chromosome 16, 50731206: 50731206
39 NOD2 NM_022162.2(NOD2): c.274G> A (p.Val92Ile) single nucleotide variant Likely benign rs187264529 GRCh38 Chromosome 16, 50699688: 50699688
40 NOD2 NM_022162.2(NOD2): c.274G> A (p.Val92Ile) single nucleotide variant Likely benign rs187264529 GRCh37 Chromosome 16, 50733599: 50733599
41 NOD2 NM_022162.2(NOD2): c.460G> A (p.Asp154Asn) single nucleotide variant Likely benign rs146054564 GRCh38 Chromosome 16, 50699874: 50699874
42 NOD2 NM_022162.2(NOD2): c.460G> A (p.Asp154Asn) single nucleotide variant Likely benign rs146054564 GRCh37 Chromosome 16, 50733785: 50733785
43 NOD2 NM_022162.2(NOD2): c.531G> A (p.Pro177=) single nucleotide variant Likely benign rs775281342 GRCh38 Chromosome 16, 50699945: 50699945
44 NOD2 NM_022162.2(NOD2): c.531G> A (p.Pro177=) single nucleotide variant Likely benign rs775281342 GRCh37 Chromosome 16, 50733856: 50733856
45 NOD2 NM_022162.2(NOD2): c.646+15T> C single nucleotide variant Likely benign rs765487015 GRCh38 Chromosome 16, 50707975: 50707975
46 NOD2 NM_022162.2(NOD2): c.646+15T> C single nucleotide variant Likely benign rs765487015 GRCh37 Chromosome 16, 50741886: 50741886
47 NOD2 NM_022162.2(NOD2): c.859C> T (p.His287Tyr) single nucleotide variant Likely benign rs560242309 GRCh37 Chromosome 16, 50744681: 50744681
48 NOD2 NM_022162.2(NOD2): c.859C> T (p.His287Tyr) single nucleotide variant Likely benign rs560242309 GRCh38 Chromosome 16, 50710770: 50710770
49 NOD2 NM_022162.2(NOD2): c.875C> T (p.Ala292Val) single nucleotide variant Likely benign rs149338478 GRCh37 Chromosome 16, 50744697: 50744697
50 NOD2 NM_022162.2(NOD2): c.875C> T (p.Ala292Val) single nucleotide variant Likely benign rs149338478 GRCh38 Chromosome 16, 50710786: 50710786

Copy number variations for Crohn's Disease from CNVD:

7 (show all 25)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19625 1 150839831 150840116 Deletion and duplication LCE3C Crohn''s disease
2 19631 1 150852910 150853198 Deletion and duplication LCE3B Crohn''s disease
3 71426 12 69818942 132349534 Copy number Crohn''s disease
4 112709 17 40930407 78774742 Copy number Crohn''s disease
5 139336 2 179004449 242951149 Copy number Crohn''s disease
6 194979 5 147200000 152100000 Low copy numbers IRGM Crohn''s disease
7 195288 5 149800000 152700000 Copy number Crohn''s disease
8 195354 5 150157836 180857866 Copy number Crohn''s disease
9 195374 5 150183562 180857866 Copy number Crohn''s disease
10 195384 5 150207878 150208422 Deletion IRGM Crohn''s disease
11 195385 5 150207878 150208422 Deletion and duplication IRGM Crohn''s disease
12 210788 6 31416574 170899992 Copy number Crohn''s disease
13 211338 6 32582950 170899992 Copy number Crohn''s disease
14 211384 6 32609209 170899992 Copy number Crohn''s disease
15 211736 6 336751 356443 Copy number IRF4 Crohn''s disease
16 230702 8 1 12700000 Copy number Crohn''s disease
17 241420 8 6200000 12700000 Copy number HBD-2 Crohn''s disease
18 241431 8 6200000 12700000 Duplication DEFB103 Crohn''s disease
19 241433 8 6200000 12700000 Duplication DEFB4 Crohn''s disease
20 241436 8 6200000 12700000 Duplication SPAG11 Crohn''s disease
21 241467 8 6200000 12700000 Low copy numbers Crohn''s disease
22 242030 8 6873390 6875823 Copy number Crohn''s disease
23 242532 8 7259842 7791647 Copy number DEFB4 Crohn''s disease
24 242534 8 7259842 7791647 Deletion and duplica tion DEFB4 Crohn''s disease
25 242535 8 7259842 7791647 Deletion and duplica tion HBD-2 Crohn''s disease
Sources

Expression for Crohn's Disease

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Crohn's Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 REG1A regenerating islet-derived 1 alpha Colon + 4.42 0.002
2 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 4.02 0.000
3 REG1B regenerating islet-derived 1 beta Colon + 3.99 0.008
4 LCN2 lipocalin 2 Colon + 3.90 0.000
5 REG3A regenerating islet-derived 3 alpha Colon + 3.74 0.026
6 CXCL11 chemokine (C-X-C motif) ligand 11 Colon + 3.70 0.016
7 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.60 0.000
8 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.50 0.004
9 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.49 0.029
10 S100A8 S100 calcium binding protein A8 Colon + 3.04 0.017
Search GEO for disease gene expression data for Crohn's Disease.
Sources

Pathways for Crohn's Disease

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Pathways related to Crohn's Disease according to KEGG:

37
# Name Kegg Source Accession
1 NOD-like receptor signaling pathway hsa04621
2 Cytokine-cytokine receptor interaction hsa04060
3 Jak-STAT signaling pathway hsa04630
4 Inflammatory bowel disease (IBD) hsa05321
5 Autophagy - animal hsa04140

Pathways related to Crohn's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.7 CEACAM6 HP IL10RA IL10RB IL12RB2 IL23R
2
Allograft rejection 1 37
Show member pathways
 12.54 ABCB1 IL10RA IL10RB IL12RB2 ITGA4
3
Regulation of IFNA signaling 66
Show member pathways
 11.95 IL10RA IL10RB IL12RB2 IL23R IRF5
4
Toxoplasmosis 37
Show member pathways
 11.83 IL10RA IL10RB IRGM ITGA4
5
Innate Lymphoid Cell Differentiation Pathways 65
11.4 IL12RB2 IL23R ITGA4
6
Jak-Stat Signaling Pathway 67
11.4 IL10RA IL10RB IL12RB2 IL23R
7
AKT Signaling Pathway 67
11.18 IL10RA IL10RB IL12RB2 IL23R ITGA4
Sources

GO Terms for Crohn's Disease

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Cellular components related to Crohn's Disease according to GeneCards Suite gene sharing: