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MCID: CRH001
MIFTS: 77

Crohn's Disease

Categories: Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Crohn's Disease

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MalaCards integrated aliases for Crohn's Disease:

Name: Crohn's Disease 38 12 76 53 25 43 15
Crohn Disease 12 25 37 6 15 73
Pediatric Crohn's Disease 12 53 73
Enteritis 53 55 73
Crohn's Disease of Large Bowel 12 73
Granulomatous Colitis 12 53
Ileitis 53 73
Pediatric Onset Crohn's Disease 53
Crohn's Disease, Pediatric 53
Crohn's Disease of Colon 12
Enteritis, Granulomatous 25
Granulomatous Enteritis 53
Colitis, Granulomatous 25
Enteritis, Regional 25
Regional Enteritis 73
Crohn's Enteritis 25

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases Genetic diseases
Anatomical: Gastrointestinal diseases Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8778
ICD9CM 35 555.1
MeSH 44 D003424
SNOMED-CT 68 50440006 7620006
KEGG 37 H00286
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Summaries for Crohn's Disease

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NIH Rare Diseases : 53 Crohn's disease is a type of inflammatory bowel disease (IBD), the general name for conditions that cause inflammation in the gastrointestinal (GI) tract. Common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. Other general symptoms include feeling tired, nausea and loss of appetite, fever, and anemia. Complications of Crohn's disease may include intestinal blockage, fistulas, anal fissures, ulcers, malnutrition, and inflammation in other areas of the body. Crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. The exact cause is unknown, but is thought to be due from a combination of certain genetic variations, changes in the immune system, and the presence of bacteria in the digestive tract.  Many of the major genes related to Crohn disease, including NOD2, ATG16L1, IL23R, and IRGM, are involved in immune system function. The disease is not inherited but it appears to run in some families because in about 15% of the cases the disease is present in more than one relative.  Treatment is aimed at relieving symptoms and reducing inflammation, and may include diet and medication, but some people require surgery. Surgery often involves removal of the diseased segment of bowel (resection), the two ends of healthy bowel are then joined together (anastomosis). In about 30% of people who have surgery for Crohn�??s disease symptoms may come back within three years and up to 60% will have recurrence within ten years.

MalaCards based summary : Crohn's Disease, also known as crohn disease, is related to inflammatory bowel disease 1 and inflammatory bowel disease 25, autosomal recessive, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Crohn's Disease is ENSG00000278769 (), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Cytokine-cytokine receptor interaction. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are digestive/alimentary and hematopoietic system

Disease Ontology : 12 An intestinal disease that involves inflammation located in intestine.

MedlinePlus : 43 Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory bowel disease. Crohn's can affect any area from the mouth to the anus. It often affects the lower part of the small intestine called the ileum. The cause of Crohn's disease is unknown. It may be due to an abnormal reaction by the body's immune system. It also seems to run in some families. It most commonly starts between the ages of 13 and 30. The most common symptoms are pain in the abdomen and diarrhea. Other symptoms include Bleeding from the rectum Weight loss Fever Your doctor will diagnose Crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. Crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. People with Crohn's can also have joint pain and skin problems. Children with the disease may have growth problems. There is no cure for Crohn's. Treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. Some people have long periods of remission, when they are free of symptoms. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Wikipedia : 76 Crohn''s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

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Related Diseases for Crohn's Disease

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Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 922)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 1 33.3 NOD2 SLC22A4 SLC22A5
2 inflammatory bowel disease 25, autosomal recessive 32.0 IL10RA IL10RB
3 colitis 30.5 ABCB1 ATG16L1 DUOX2 IL10RA IL10RB IL23R
4 ulcerative colitis 30.4 ABCB1 ATG16L1 IL10RA IL10RB IL23R IRF5
5 spondylarthropathy 29.9 HP NOD2
6 intestinal disease 29.6 ATG16L1 IL23R MUC2 NOD2
7 inflammatory bowel disease 5 29.6 ATG16L1 IL23R NOD2 SLC22A4 SLC22A5
8 rheumatoid arthritis 29.5 IRF5 LACC1 S100A12 SLC11A1 SLC22A4
9 psoriatic arthritis 29.5 IL23R NOD2 S100A12
10 inflammatory bowel disease 29.1 ABCB1 ATG16L1 DUOX2 IL10RA IL10RB IL23R
11 ileitis 12.7
12 thoraco abdominal enteric duplication 12.4
13 cryptogenic multifocal ulcerous stenosing enteritis 12.2
14 enteric pattern testicular yolk sac tumor 12.1
15 trichohepatoenteric syndrome 1 11.9
16 diarrhea 4, malabsorptive, congenital 11.6
17 eosinophilic gastroenteritis 11.5
18 pulmonary alveolar microlithiasis 11.3
19 intestinal pseudo-obstruction 11.3
20 coccidiosis 11.3
21 hirschsprung disease 1 11.3
22 amebiasis 11.3
23 campylobacteriosis 11.3
24 duodenitis 11.3
25 coccidioidomycosis 11.3
26 eosinophilic enteropathy 11.3
27 aspiration pneumonia 11.2
28 visceral myopathy 11.2
29 head injury 11.2
30 thiopurines, poor metabolism of, 1 11.2
31 hermansky-pudlak syndrome 4 11.2
32 hermansky-pudlak syndrome 5 11.2
33 influenza 11.1
34 herpes simplex 11.1
35 hepatitis c 11.1
36 trichinosis 11.1
37 brain injury 11.1
38 sleeping sickness 11.1
39 traumatic brain injury 11.1
40 gastrointestinal tularemia 11.1
41 cyclic neutropenia 11.1
42 giardiasis 11.1
43 strongyloidiasis 11.1
44 chagas disease 11.1
45 hirschsprung disease 2 11.1
46 cervical cancer 11.1
47 liver cirrhosis 11.1
48 cysticercosis 11.1
49 tetanus 11.1
50 tularemia 11.1

Comorbidity relations with Crohn's Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Inflammatory Bowel Disease 1
Intestinal Obstruction Protein-Energy Malnutrition
Ulcerative Colitis

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to Crohn's Disease
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Symptoms & Phenotypes for Crohn's Disease

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UMLS symptoms related to Crohn's Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 ABCB1 ATG16L1 IL10RA IL10RB IL23R MUC2
2 hematopoietic system MP:0005397 9.9 ABCB1 ATG16L1 HP IL10RA IL10RB IL23R
3 homeostasis/metabolism MP:0005376 9.77 ABCB1 ATG16L1 DUOX2 HP IL10RA IL10RB
4 immune system MP:0005387 9.4 ABCB1 ATG16L1 HP IL10RA IL10RB IL23R
Sources

Drugs & Therapeutics for Crohn's Disease

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Drugs for Crohn's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 437)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
2
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
3
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
5
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
6
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
7
Rifabutin Approved, Investigational Phase 4,Phase 3 72559-06-9 6323490
8
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
10
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
12
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
13
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
14
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
15
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
16
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
17 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 943609-66-3
18
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
19 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20
Racepinephrine Approved Phase 4,Phase 2,Not Applicable 329-65-7 838
21
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 51-43-4 5816
22
Azithromycin Approved Phase 4 83905-01-5 55185 447043
23
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
24
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 59-05-2, 1959-05-2 126941
25
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
26
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
27
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
28
Phytonadione Approved, Investigational Phase 4,Phase 1 84-80-0 4812 5284607
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
30
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
31
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
32
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
33
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
34
Ustekinumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 815610-63-0
35
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
36
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
37
Everolimus Approved Phase 4 159351-69-6 6442177
38
Dextromethorphan Approved Phase 4,Phase 1 125-71-3 5360696 5362449
39
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 93-14-1 3516
40
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
41
Losartan Approved Phase 4 114798-26-4 3961
42
Caffeine Approved Phase 4,Phase 1 58-08-2 2519
43
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 50-02-2 5743
44
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 1177-87-3
45
Thioguanine Approved Phase 4 154-42-7 2723601
46
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 564-25-0 54671203
47
Vancomycin Approved Phase 4,Phase 2 1404-90-6 14969 441141
48
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
49
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
50
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662

Interventional clinical trials:

(show top 50) (show all 1259)
# Name Status NCT ID Phase Drugs
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
5 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
6 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
7 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
8 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
9 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
12 Does Clinical Response Correlate With Serum Certolizumab Levels? Unknown status NCT02597829 Phase 4 Certolizumab Pegol
13 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
14 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
15 Anemia in Inflammatory Bowel Disease Unknown status NCT02760940 Phase 4 oral liposomal iron
16 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
17 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
18 Prucalopride Prior to Small Bowel Capsule Endoscopy Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
19 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
20 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
21 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
22 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
23 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
24 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
25 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
26 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
27 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
28 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
29 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
30 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
31 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
32 Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease Completed NCT02630966 Phase 4 Vedolizumab;Placebo
33 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
34 Vitamin D Supplementation in Adult Crohn's Disease Completed NCT01369667 Phase 4
35 Adalimumab-psoriasis and Small Bowel Lesions Completed NCT01556672 Phase 4 Adalimumab
36 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4 risedronate;placebo
37 Early Immunosuppressants in Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
38 Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Completed NCT00280956 Phase 4 natalizumab
39 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
40 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
41 The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Completed NCT01235325 Phase 4
42 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
43 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
44 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
45 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
46 Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation Completed NCT02269358 Phase 4 METHOTREXATE
47 Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
48 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
49 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4 Infliximab
50 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate

Search NIH Clinical Center for Crohn's Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Crohn's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Crohn's Disease:
Bone marow-derived mesenchymal stem cells for the treatment of Crohn's disease
Hematopoietic stem cell transplantation for Crohn's disease
Hematopoietic stem cells for severe Crohn's disease
Ovasave�, antigen-specific regulatory T-cells for refractory Crohn's disease
PDA001, Placenta-derived cells for Crohn's disease
Periperal blood-derived CD34+ stem cells for treatment of Crohn's disease
Prochymal�, mesenchymal stem cells for treatment of Crohn's disease
Regenerative ColoTherapy�, stem cells for inflammatory bowel diseases
Embryonic/Adult Cultured Cells Related to Crohn's Disease:
Bone marrow-derived mesenchymal stem cell
Peripheral blood-derived hematopoietic stem cells (family) PMIDs: 15549303
Ovalbumin speci?c type 1 regulatory T- cells (Ovasave�) PMIDs: 22885333 19539556
Placenta-derived cells PMIDs: 23429460
Bone marrow-derived mesenchymal stem cells PMIDs: 19530993 21787241
Adipose-derived mesenchymal stem cells (family)
Sources

Genetic Tests for Crohn's Disease

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Sources

Anatomical Context for Crohn's Disease

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MalaCards organs/tissues related to Crohn's Disease:

41
Colon, Bone, T Cells, Skin, Testes, Small Intestine, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Disease:

19
Intestine
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
Sources

Publications for Crohn's Disease

About this section

Articles related to Crohn's Disease:

(show top 50) (show all 6008)
# Title Authors Year
1
Association of T Helper 1 Cytokine Gene Single Nucleotide Polymorphisms with Ulcerative Colitis and Crohn's Disease. ( 30134230 )
2019
2
Real-World Outcomes of Vedolizumab Therapy in Ulcerative Colitis and Crohn's Disease at a Tertiary Referral Center. ( 30134234 )
2019
3
Fecal calprotectin is significantly linked to azathioprine metabolite concentrations in Crohn's disease. ( 30212402 )
2019
4
Paradoxical pustular psoriasis induced by ustekinumab in a patient with Crohn's disease-associated spondyloarthropathy. ( 29705819 )
2018
5
Optimized thiopurine therapy before withdrawal of anti-tumour necrosis factor-I+ in patients with Crohn's disease. ( 29975242 )
2018
6
Colonic perforation due to GI histoplasmosis in an immunocompetent host mimicking Crohn's disease. ( 29337040 )
2018
7
Does a histologically inflamed resection margin increase postoperative complications in patients with Crohn's disease? ( 29431516 )
2018
8
Anti-infliximab antibody concentrations can guide treatment intensification in patients with Crohn's disease who lose clinical response. ( 29226370 )
2018
9
Intestinal paracoccidioidomycosis resembling Crohn's disease in a teenager: a case report. ( 29706133 )
2018
10
Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease-when to look for it? ( 29446132 )
2018
11
Endoscopic valvectomy of ileocecal valve stricture resulting in resolution of ileitis in Crohn's disease. ( 29476842 )
2018
12
Filgotinib for the treatment of Crohn's disease. ( 29448862 )
2018
13
The state of the art on treatment of Crohn's disease. ( 29980848 )
2018
14
Infliximab-Induced Tubulointerstitial Nephritis with Image Findings of Striated Nephrogram in Crohn's Disease. ( 29973427 )
2018
15
Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians. ( 29960072 )
2018
16
Endospore forming bacteria may be associated with maintenance of surgically-induced remission in Crohn's disease. ( 29950676 )
2018
17
Assessment of factors associated with smoking cessation at diagnosis or during follow-up of Crohn's disease. ( 28556205 )
2018
18
Paracoccidioidomycosis simulating Crohn's disease. ( 29746902 )
2018
19
IgG4-Related Disease Mimicking Crohn's Disease: A Case Report and Review of Literature. ( 29417330 )
2018
20
Gastrointestinal Diaphragm Disease With Retained Capsule Endoscope, Associated With Crohn's Disease: A Case Report. ( 29890901 )
2018
21
Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence. ( 29434453 )
2018
22
[X-linked inhibitor of apoptosis deficiency manifested as Crohn's disease: a case report and literature review]. ( 29342997 )
2018
23
Utility of proactive infliximab levels in paediatric Crohn's disease. ( 29950353 )
2018
24
Diagnostic dilemma: think about anterior cutaneous nerve entrapment syndrome (ACNES) in patients with atypical abdominal pain and Crohn's disease. ( 29593000 )
2018
25
What Is the Risk of Progressive Multifocal Leukoencephalopathy in Patients With Ulcerative Colitis or Crohn's Disease Treated With Vedolizumab? ( 29668955 )
2018
26
Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. ( 29434451 )
2018
27
Persistent neutrophilic scarring alopecia triggered by anti-TNF blockade for Crohn's disease. ( 29976546 )
2018
28
Crohn's Disease in Niemann-Pick Disease Type C1: Caught in the Cross-Fire of Host-Microbial Interactions. ( 29411209 )
2018
29
A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population. ( 29441677 )
2018
30
Pulmonary co-infection with nocardia species and nontuberculous mycobacteria mimicking miliary tuberculosis in a patient with Crohn's disease under combined immunosuppressive therapy. ( 29890558 )
2018
31
High Incidence of Recurrent Crohn's Disease Following Colectomy for Ulcerative Colitis Revealed with Long Follow-Up. ( 29282640 )
2018
32
Postoperative therapy with infliximab for Crohn's disease: a 2-year prospective randomized multicenter study in Japan. ( 29383596 )
2018
33
Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn's disease. ( 29129496 )
2018
34
Prognostic value of preoperative neutrophil-to-lymphocyte ratio in Crohn's disease. ( 29435759 )
2018
35
Isolated Terminal Ileitis: When Is It Not Crohn's Disease? ( 29536222 )
2018
36
Ileum Histoplasmosis Mimicking Intestinal Tuberculosis and Crohn's Disease. ( 29515346 )
2018
37
Cutaneous manifestations of metastatic Crohn's disease. ( 29952016 )
2018
38
Budd-Chiari syndrome: a rare and life-threatening complication of Crohn's disease. ( 29348288 )
2018
39
Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease. ( 29961815 )
2018
40
SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn's Disease with Significant Inverse Correlation to Disease Activity. ( 29977289 )
2018
41
Developing a core outcome set for fistulising perianal Crohn's disease. ( 29437911 )
2018
42
A Challenging Case of Retroperitoneal Abscess in a Post-Partum Crohn's Disease Patient. ( 29961750 )
2018
43
Diagnostic Performance of a 5-Marker Predictive Model for Differential Diagnosis Between Intestinal Tuberculosis and Crohn's Disease. ( 29860270 )
2018
44
Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease-when to look for it? Authors' reply. ( 29446137 )
2018
45
Superior Mesenteric Artery Syndrome in Patients with Crohn's Disease: A Description of 2 Cases Studied with a Novel Magnetic Resonance Enterography (MRE) Procedure. ( 29643328 )
2018
46
Crohn's disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan. ( 29948302 )
2018
47
Pulmonary strongyloidiasis causing septic shock in a patient with Crohn's disease. ( 29977759 )
2018
48
Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease. ( 29951563 )
2018
49
Histologic features in pediatric ileitis: Is it possible to tip the balance towards Crohn's disease? ( 29397324 )
2018
50
Dissecting Cellulitis of the Scalp: A Rare Dermatological Manifestation of Crohn's Disease. ( 29430467 )
2018
Sources

Variations for Crohn's Disease

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Expression for Crohn's Disease

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LifeMap Discovery
Genes differentially expressed in tissues of Crohn's Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 REG1A regenerating islet-derived 1 alpha Colon + 4.42 0.002
2 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 4.02 0.000
3 REG1B regenerating islet-derived 1 beta Colon + 3.99 0.008
4 LCN2 lipocalin 2 Colon + 3.90 0.000
5 REG3A regenerating islet-derived 3 alpha Colon + 3.74 0.026
6 CXCL11 chemokine (C-X-C motif) ligand 11 Colon + 3.70 0.016
7 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.60 0.000
8 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.50 0.004
9 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.49 0.029
10 S100A8 S100 calcium binding protein A8 Colon + 3.04 0.017
Search GEO for disease gene expression data for Crohn's Disease.
Sources

Pathways for Crohn's Disease

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Pathways related to Crohn's Disease according to KEGG:

37
# Name Kegg Source Accession
1 NOD-like receptor signaling pathway hsa04621
2 Cytokine-cytokine receptor interaction hsa04060
3 JAK-STAT signaling pathway hsa04630
4 Inflammatory bowel disease (IBD) hsa05321
5 Autophagy - animal hsa04140

Pathways related to Crohn's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Jak-Stat Signaling Pathway (sino) 67
10.74 IL10RA IL10RB IL23R
Sources

GO Terms for Crohn's Disease

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Cellular components related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 ABCB1 CEACAM6 DUOX2 IL10RA IL10RB IL23R
2 autophagosome membrane GO:0000421 9.16 ATG16L1 IRGM
3 apical plasma membrane GO:0016324 9.02 ABCB1 CEACAM6 DUOX2 SLC22A4 SLC22A5

Biological processes related to Crohn's Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.99 IL23R INAVA IRF5 IRGM NOD2
2 inflammatory response GO:0006954 9.91 IL10RB IL23R IRGM S100A12 SLC11A1
3 innate immune response GO:0045087 9.85 IL23R INAVA IRF5 IRGM NOD2 S100A12
4 defense response GO:0006952 9.8 HP IRGM NOD2
5 defense response to Gram-negative bacterium GO:0050829 9.74 IL23R IRGM SLC11A1
6 defense response to bacterium GO:0042742 9.72 HP IRGM NOD2 S100A12 SLC11A1
7 drug transmembrane transport GO:0006855 9.62 ABCB1 SLC22A5
8 positive regulation of interleukin-12 production GO:0032735 9.61 IL23R IRF5
9 positive regulation of interleukin-10 production GO:0032733 9.61 INAVA NOD2
10 response to interferon-gamma GO:0034341 9.6 IL23R SLC11A1
11 maintenance of gastrointestinal epithelium GO:0030277 9.58 MUC2 NOD2
12 positive regulation of interleukin-17 production GO:0032740 9.58 IL23R NOD2
13 positive regulation of interleukin-1 beta production GO:0032731 9.56 INAVA NOD2
14 positive regulation of T-helper 1 type immune response GO:0002827 9.55 IL23R SLC11A1
15 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.54 NOD2 SLC11A1
16 response to peptidoglycan GO:0032494 9.52 INAVA IRF5
17 carnitine transport GO:0015879 9.49 SLC22A4 SLC22A5
18 protein lipidation involved in autophagosome assembly GO:0061739 9.48 ATG16L1 IRGM
19 quaternary ammonium group transport GO:0015697 9.46 SLC22A4 SLC22A5
20 carnitine transmembrane transport GO:1902603 9.43 SLC22A4 SLC22A5
21 positive regulation of stress-activated MAPK cascade GO:0032874 9.43 IL26 INAVA NOD2
22 cytokine-mediated signaling pathway GO:0019221 9.43 DUOX2 IL10RA IL10RB IL23R IL26 IRF5
23 cytokine production involved in immune response GO:0002367 9.4 INAVA NOD2
24 response to muramyl dipeptide GO:0032495 9.33 INAVA IRF5 NOD2
25 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 8.8 INAVA IRGM NOD2

Molecular functions related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.43 ABCB1 SLC22A4 SLC22A5
2 CARD domain binding GO:0050700 9.32 IRGM NOD2
3 quaternary ammonium group transmembrane transporter activity GO:0015651 9.16 SLC22A4 SLC22A5
4 carnitine transmembrane transporter activity GO:0015226 8.96 SLC22A4 SLC22A5
5 interleukin-10 receptor activity GO:0004920 8.62 IL10RA IL10RB
6 protein binding GO:0005515 10.27 ABCB1 ATG16L1 CEACAM6 HP IL10RA IL10RB
Sources

Sources for Crohn's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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