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MCID: CRH001
MIFTS: 79

Crohn's Disease

Categories: Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Crohn's Disease

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MalaCards integrated aliases for Crohn's Disease:

Name: Crohn's Disease 39 12 77 54 26 44 15 17
Crohn Disease 12 26 38 6 15 74
Pediatric Crohn's Disease 12 54 74
Enteritis 54 56 74
Crohn's Disease of Large Bowel 12 74
Granulomatous Colitis 12 54
Ileitis 54 74
Pediatric Onset Crohn's Disease 54
Crohn's Disease, Pediatric 54
Crohn's Disease of Colon 12
Enteritis, Granulomatous 26
Granulomatous Enteritis 54
Colitis, Granulomatous 26
Enteritis, Regional 26
Regional Enteritis 74
Crohn's Enteritis 26

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases Genetic diseases
Anatomical: Gastrointestinal diseases Skin diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:8778
KEGG 38 H00286
ICD9CM 36 555.1
MeSH 45 D003424
SNOMED-CT 69 50440006 7620006
ICD10 34 A04.6 K50.1
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Summaries for Crohn's Disease

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NIH Rare Diseases : 54 Crohn's disease is a type of inflammatory bowel disease (IBD), the general name for conditions that cause inflammation in the gastrointestinal (GI) tract. Common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. Other general symptoms include feeling tired, nausea and loss of appetite, fever, and anemia. Complications of Crohn's disease may include intestinal blockage, fistulas, anal fissures, ulcers, malnutrition, and inflammation in other areas of the body. Crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. The exact cause is unknown, but is thought to be due from a combination of certain genetic variations, changes in the immune system, and the presence of bacteria in the digestive tract.  Many of the major genes related to Crohn disease, including NOD2, ATG16L1, IL23R, and IRGM, are involved in immune system function. The disease is not inherited but it appears to run in some families because in about 15% of the cases the disease is present in more than one relative.  Treatment is aimed at relieving symptoms and reducing inflammation, and may include diet and medication, but some people require surgery. Surgery often involves removal of the diseased segment of bowel (resection), the two ends of healthy bowel are then joined together (anastomosis). In about 30% of people who have surgery for Crohn�??s disease symptoms may come back within three years and up to 60% will have recurrence within ten years.

MalaCards based summary : Crohn's Disease, also known as crohn disease, is related to inflammatory bowel disease 1 and inflammatory bowel disease 25, autosomal recessive, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Crohn's Disease is ENSG00000278769 (), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Cytokine-cytokine receptor interaction. The drugs Infliximab and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An intestinal disease that involves inflammation located in intestine.

MedlinePlus : 44 Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory bowel disease. Crohn's can affect any area from the mouth to the anus. It often affects the lower part of the small intestine called the ileum. The cause of Crohn's disease is unknown. It may be due to an abnormal reaction by the body's immune system. It also seems to run in some families. It most commonly starts between the ages of 13 and 30. The most common symptoms are pain in the abdomen and diarrhea. Other symptoms include Bleeding from the rectum Weight loss Fever Your doctor will diagnose Crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. Crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. People with Crohn's can also have joint pain and skin problems. Children with the disease may have growth problems. There is no cure for Crohn's. Treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. Some people have long periods of remission, when they are free of symptoms. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Wikipedia : 77 Crohn''s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

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Related Diseases for Crohn's Disease

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Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1385)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 1 33.9 NOD2 SLC22A4 SLC22A5
2 inflammatory bowel disease 25, autosomal recessive 32.3 IL10RA IL10RB
3 ulcerative colitis 30.9 ABCB1 ATG16L1 IL10RA IL10RB IL23R IRF5
4 colitis 30.9 ABCB1 ATG16L1 DUOX2 IL10RA IL10RB IL23R
5 inflammatory bowel disease 30.9 ABCB1 ATG16L1 IL10RA IL10RB IL18RAP IL23R
6 rheumatoid arthritis 30.4 IRF5 LACC1 S100A12 SLC11A1 SLC22A4
7 psoriatic arthritis 30.4 IL23R NOD2 S100A12
8 spondylarthropathy 30.3 HP NOD2
9 intestinal disease 30.1 ATG16L1 IL23R NOD2
10 leprosy 3 29.9 LACC1 NOD2 SLC11A1
11 inflammatory bowel disease 5 29.8 ATG16L1 IL23R NOD2 SLC22A4 SLC22A5
12 thoraco abdominal enteric duplication 12.4
13 gastroduodenal crohn's disease 12.4
14 crohn's disease of the esophagus 12.3
15 enteric pattern testicular yolk sac tumor 12.1
16 trichohepatoenteric syndrome 1 12.1
17 diarrhea 4, malabsorptive, congenital 11.6
18 melkersson-rosenthal syndrome 11.5
19 pyoderma gangrenosum 11.4
20 orofacial granulomatosis 11.4
21 diarrhea 11.4
22 colorectal cancer 11.4
23 epidermolysis bullosa acquisita 11.4
24 skin tag 11.4
25 keratomalacia 11.3
26 pulmonary alveolar microlithiasis 11.3
27 coccidiosis 11.3
28 hirschsprung disease 1 11.3
29 amebiasis 11.3
30 campylobacteriosis 11.3
31 aspiration pneumonia 11.3
32 head injury 11.3
33 visceral myopathy 11.3
34 hermansky-pudlak syndrome 4 11.2
35 hermansky-pudlak syndrome 5 11.2
36 inflammatory bowel disease 29 11.2
37 brain injury 11.1
38 trichinosis 11.1
39 gastrointestinal tularemia 11.1
40 traumatic brain injury 11.1
41 sleeping sickness 11.1
42 chagas disease 11.1
43 tetanus 11.1
44 hirschsprung disease 2 11.1
45 cysticercosis 11.1
46 tularemia 11.1
47 anthrax disease 11.1
48 erythromelalgia 11.1
49 inflammatory bowel disease 10 11.1
50 inflammatory bowel disease 13 11.1

Comorbidity relations with Crohn's Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Inflammatory Bowel Disease 1
Intestinal Obstruction Protein-Energy Malnutrition
Ulcerative Colitis

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to Crohn's Disease
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Symptoms & Phenotypes for Crohn's Disease

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UMLS symptoms related to Crohn's Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ABCB1 ATG16L1 HP IL10RA IL10RB IL18RAP
2 digestive/alimentary MP:0005381 9.86 ABCB1 ATG16L1 IL10RA IL10RB IL23R NOD2
3 homeostasis/metabolism MP:0005376 9.77 ABCB1 ATG16L1 DUOX2 HP IL10RA IL10RB
4 immune system MP:0005387 9.4 ABCB1 ATG16L1 HP IL10RA IL10RB IL18RAP
Sources

Drugs & Therapeutics for Crohn's Disease

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Drugs for Crohn's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 461)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
2
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
3
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
5
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
6
Rifabutin Approved, Investigational Phase 4,Phase 3 72559-06-9 6323490 46783538
7
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
8
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
10
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
11
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
13
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
14
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6, 15438-31-0 23925 27284
15
Prucalopride Approved Phase 4 179474-81-8
16
Azathioprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 446-86-6 2265
17
Mercaptopurine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-44-2 667490
18
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 443-48-1 4173
19
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
21
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 51-43-4 5816
22
Racepinephrine Approved Phase 4,Phase 2,Not Applicable 329-65-7 838
23
Azithromycin Approved Phase 4 83905-01-5 55185 447043
24
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
25
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
26 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 943609-66-3
27
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
28
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
29
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
30
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
31
Phylloquinone Approved, Investigational Phase 4,Phase 1 84-80-0
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
33
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
34
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
35
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
36
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
37
Ustekinumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 815610-63-0
38
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
39
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
40
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
41
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 93-14-1 3516
42
Dextromethorphan Approved Phase 4,Phase 1 125-71-3 5362449 5360696
43
Caffeine Approved Phase 4,Phase 1 58-08-2 2519
44
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
45
Losartan Approved Phase 4 114798-26-4 3961
46
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 1177-87-3
47
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 50-02-2 5743
48
Thioguanine Approved Phase 4 154-42-7 2723601
49
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 564-25-0 54671203
50
Vancomycin Approved Phase 4,Phase 2 1404-90-6 441141 14969

Interventional clinical trials:

(show top 50) (show all 1298)
# Name Status NCT ID Phase Drugs
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
5 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
6 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
7 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
8 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
9 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
12 Does Clinical Response Correlate With Serum Certolizumab Levels? Unknown status NCT02597829 Phase 4 Certolizumab Pegol
13 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
14 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
15 Brief Escalation of Adalimumab Treatment for Prevention of Clinical Relapse in IBD Unknown status NCT03059849 Phase 4 Adalimumab
16 Anemia in Inflammatory Bowel Disease Unknown status NCT02760940 Phase 4 oral liposomal iron
17 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
18 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
19 Prucalopride Prior to Small Bowel Capsule Endoscopy Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
20 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
21 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
22 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
23 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
24 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
25 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
26 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
27 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
28 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
29 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
30 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
31 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
32 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
33 Pediatric Crohn's Disease AdalImumab Level-based Optimization Treatment (PAILOT) Trial Completed NCT02256462 Phase 4 Adalimumab
34 Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease Completed NCT02630966 Phase 4 Vedolizumab;Placebo
35 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
36 Vitamin D Supplementation in Adult Crohn's Disease Completed NCT01369667 Phase 4
37 Adalimumab-psoriasis and Small Bowel Lesions Completed NCT01556672 Phase 4 Adalimumab
38 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4 risedronate;placebo
39 Early Immunosuppressants in Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
40 Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Completed NCT00280956 Phase 4 natalizumab
41 Postmarketing Vedolizumab Milk-Only Lactation Study in Lactating Women With Active Ulcerative Colitis or Crohn's Disease Completed NCT02559713 Phase 4 Vedolizumab
42 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
43 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
44 The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Completed NCT01235325 Phase 4
45 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
46 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
47 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
48 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
49 Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation Completed NCT02269358 Phase 4 METHOTREXATE
50 Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab

Search NIH Clinical Center for Crohn's Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Crohn's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Crohn's Disease:
Bone marow-derived mesenchymal stem cells for the treatment of Crohn's disease
Hematopoietic stem cell transplantation for Crohn's disease
Hematopoietic stem cells for severe Crohn's disease
Ovasave�, antigen-specific regulatory T-cells for refractory Crohn's disease
PDA001, Placenta-derived cells for Crohn's disease
Periperal blood-derived CD34+ stem cells for treatment of Crohn's disease
Prochymal�, mesenchymal stem cells for treatment of Crohn's disease
Regenerative ColoTherapy�, stem cells for inflammatory bowel diseases
Embryonic/Adult Cultured Cells Related to Crohn's Disease:
Bone marrow-derived mesenchymal stem cell
Peripheral blood-derived hematopoietic stem cells (family) PMIDs: 15549303
Ovalbumin speci?c type 1 regulatory T- cells (Ovasave�) PMIDs: 22885333 19539556
Placenta-derived cells PMIDs: 23429460
Bone marrow-derived mesenchymal stem cells PMIDs: 19530993 21787241
Adipose-derived mesenchymal stem cells (family)
Sources

Genetic Tests for Crohn's Disease

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Sources

Anatomical Context for Crohn's Disease

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MalaCards organs/tissues related to Crohn's Disease:

42
Colon, Bone, T Cells, Testes, Skin, Small Intestine, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Disease:

20
Intestine
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
Sources

Publications for Crohn's Disease

About this section

Articles related to Crohn's Disease:

(show top 50) (show all 7980)
# Title Authors Year
1
Acute pancreatitis associated with indigo naturalis in pediatric severe Crohn's disease. ( 30317857 )
2019
2
Ustekinumab Safety in Psoriasis, Psoriatic Arthritis, and Crohn's Disease: An Integrated Analysis of Phase II/III Clinical Development Programs. ( 30739254 )
2019
3
Cheilitis and gingivitis as first signs of Crohn's disease in a pediatric patient. ( 30847214 )
2019
4
Off-label prescriptions of drugs used for the treatment of Crohn's disease or ulcerative colitis. ( 30908719 )
2019
5
Benefit-Risk Assessment of Vedolizumab in the Treatment of Crohn's Disease and Ulcerative Colitis. ( 30830573 )
2019
6
Best practices on immunomodulators and biological agents for Ulcerative colitis and Crohn's disease in Asia. ( 30848854 )
2019
7
Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models. ( 30850233 )
2019
8
Diffuse colitis cystica profunda in Crohn's disease: A potential diagnostic pitfall. ( 30856259 )
2019
9
Distinct patterns of naïve, activated and memory T and B cells in blood of patients with ulcerative colitis or Crohn's disease. ( 30883691 )
2019
10
Untargeted Metabolomics and Inflammatory Markers Profiling in Children With Crohn's Disease and Ulcerative Colitis-A Preliminary Study. ( 30772902 )
2019
11
Depression and resilience in ulcerative colitis and Crohn's disease patients with ostomy. ( 30793856 )
2019
12
Shorter Disease Duration Is Associated With Higher Rates of Response to Vedolizumab in Patients With Crohn's Disease But Not Ulcerative Colitis. ( 30625408 )
2019
13
Backwash ileitis in ulcerative colitis: Are there MR enterographic features that distinguish it from Crohn disease? ( 30599862 )
2019
14
Association of T Helper 1 Cytokine Gene Single Nucleotide Polymorphisms with Ulcerative Colitis and Crohn's Disease. ( 30134230 )
2019
15
Real-World Outcomes of Vedolizumab Therapy in Ulcerative Colitis and Crohn's Disease at a Tertiary Referral Center. ( 30134234 )
2019
16
Altered uric acid metabolism in isolated colonic Crohn's disease but not ulcerative colitis. ( 29926959 )
2019
17
Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis. ( 29788234 )
2019
18
No Association Between Consumption of Sweetened Beverages and Risk of Later-Onset Crohn's Disease or Ulcerative Colitis. ( 29751165 )
2019
19
Development of Infliximab Target Concentrations during Induction in Pediatric Crohn's Disease Patients. ( 30768541 )
2019
20
A Novel Rare Missense Variation of the NOD2 Gene: Evidencesof Implication in Crohn's Disease. ( 30769939 )
2019
21
Acute abdominal pain in patients with Crohn's disease: what urgent imaging tests should be done? ( 30772003 )
2019
22
Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease. ( 30772343 )
2019
23
Association Between Level of Fecal Calprotectin and Progression of Crohn's Disease. ( 30772585 )
2019
24
Successful EUS-guided Drainage of a Persistent Subdiaphragmatic Fluid Collection in a Patient With Crohn's Disease. ( 30772910 )
2019
25
The long and winding road: from genetic risk factors to the understanding of disease-pathogenesis in Crohn's disease. ( 30773533 )
2019
26
Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients With Crohn's Disease. ( 30776076 )
2019
27
Blood-derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. ( 30779925 )
2019
28
Risk of surgery in patients with stricturing type of Crohn's disease at the initial diagnosis: a single center experience. ( 30781932 )
2019
29
Combination of colonoscopy and magnetic resonance enterography is more useful for clinical decision making than colonoscopy alone in patients with complicated Crohn's disease. ( 30785943 )
2019
30
Anti-Saccharomyces Cerevisiae Antibodies as a Prognostic Biomarker in Children with Crohn's disease. ( 30789863 )
2019
31
Update on C-reactive protein and fecal calprotectin: are they accurate measures of disease activity in Crohn's disease? ( 30791776 )
2019
32
T cell clonal expansions in ileal Crohn's disease are associated with smoking behaviour and postoperative recurrence. ( 30792246 )
2019
33
Evaluating the effectiveness of infliximab on perianal fistulizing Crohn's disease by magnetic resonance imaging. ( 30792866 )
2019
34
Adalimumab for patients with Crohn's disease complicated by intra-abdominal abscess: a multicentre, prospective, observational cohort study. ( 30794285 )
2019
35
The Crohn's disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells. ( 30794691 )
2019
36
Ustekinumab in a patient with pyoderma gangrenosum and refractory Crohn's disease. ( 30795905 )
2019
37
Streptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn's Disease? ( 30796823 )
2019
38
Evaluating Metagenomic Prediction of the Metaproteome in a 4.5-Year Study of a Patient with Crohn's Disease. ( 30801026 )
2019
39
The Unsolved Link of Genetic Markers and Crohn's Disease Progression: A North American Cohort Experience. ( 30801121 )
2019
40
Crohn's Disease Complicated with Extensive Thrombosis of Limbs and Mesenteric Arteries: A Case report and literature review. ( 30802583 )
2019
41
A review of reports on single-incision laparoscopic surgery for Crohn's disease. ( 30805721 )
2019
42
Cumulative Inflammation Could Be a Risk Factor for Intestinal Failure in Crohn's Disease. ( 30806860 )
2019
43
Low-dose metronidazole is associated with a decreased rate of endoscopic recurrence of Crohn's disease after ileal resection: a retrospective cohort study. ( 30809655 )
2019
44
Fecal microbiota dynamics and its relation with disease course in Crohn's disease. ( 30810207 )
2019
45
Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's Disease. ( 30814550 )
2019
46
Genetic polymorphisms in tumour necrosis factor receptors (TNFRSF1A/1B) illustrate differential treatment response to TNFα inhibitors in patients with Crohn's disease. ( 30815272 )
2019
47
Efficacy of Infliximab in Crohn's Disease Patients with Prior Primary-Nonresponse to Tumor Necrosis Factor Antagonists. ( 30815825 )
2019
48
Darvadstrocel for the treatment of patients with perianal fistulas in Crohn's disease. ( 30816884 )
2019
49
Influence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome. ( 30818349 )
2019
50
Human Endogenous Retroviruses: Residues of Ancient Times Are Differentially Expressed in Crohn's Disease. ( 30820434 )
2019
Sources

Variations for Crohn's Disease

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Expression for Crohn's Disease

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LifeMap Discovery
Genes differentially expressed in tissues of Crohn's Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 REG1A regenerating islet-derived 1 alpha Colon + 4.42 0.002
2 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 4.02 0.000
3 REG1B regenerating islet-derived 1 beta Colon + 3.99 0.008
4 LCN2 lipocalin 2 Colon + 3.90 0.000
5 REG3A regenerating islet-derived 3 alpha Colon + 3.74 0.026
6 CXCL11 chemokine (C-X-C motif) ligand 11 Colon + 3.70 0.016
7 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.60 0.000
8 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.50 0.004
9 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.49 0.029
10 S100A8 S100 calcium binding protein A8 Colon + 3.04 0.017
Search GEO for disease gene expression data for Crohn's Disease.
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Pathways for Crohn's Disease

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Pathways related to Crohn's Disease according to KEGG:

38
# Name Kegg Source Accession
1 NOD-like receptor signaling pathway hsa04621
2 Cytokine-cytokine receptor interaction hsa04060
3 JAK-STAT signaling pathway hsa04630
4 Inflammatory bowel disease (IBD) hsa05321
5 Autophagy - animal hsa04140

Pathways related to Crohn's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.61 CEACAM6 HP IL10RA IL10RB IL18RAP IL23R
2
Th17 cell differentiation 38
Show member pathways
 11.99 IL10RB IL18RAP IL23R NOD2
3
Immune response IL-23 signaling pathway 23
Show member pathways
 11.79 IL10RA IL10RB IL18RAP IL23R
4
Th1 Differentiation Pathway 66
Show member pathways
 11.55 IL18RAP IL23R IL26
5
Jak-Stat Signaling Pathway (sino) 68
10.74 IL10RA IL10RB IL23R
Sources

GO Terms for Crohn's Disease

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Cellular components related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 ABCB1 CEACAM6 DUOX2 IL10RA IL10RB IL18RAP
2 autophagosome membrane GO:0000421 9.16 ATG16L1 IRGM
3 apical plasma membrane GO:0016324 9.02 ABCB1 CEACAM6 DUOX2 SLC22A4 SLC22A5

Biological processes related to Crohn's Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.98 IL23R INAVA IRF5 IRGM NOD2
2 innate immune response GO:0045087 9.88 IL23R INAVA IRF5 IRGM NOD2 S100A12
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL18RAP NOD2 S100A12
4 defense response GO:0006952 9.79 HP IRGM NOD2
5 defense response to bacterium GO:0042742 9.77 HP IRGM NOD2 S100A12 SLC11A1
6 defense response to Gram-negative bacterium GO:0050829 9.74 IL23R IRGM SLC11A1
7 inflammatory response GO:0006954 9.73 IL10RB IL18RAP IL23R IRGM S100A12 SLC11A1
8 drug transmembrane transport GO:0006855 9.61 ABCB1 SLC22A5
9 positive regulation of interleukin-12 production GO:0032735 9.61 IL23R IRF5
10 positive regulation of interleukin-10 production GO:0032733 9.6 INAVA NOD2
11 response to interferon-gamma GO:0034341 9.59 IL23R SLC11A1
12 positive regulation of interleukin-17 production GO:0032740 9.58 IL23R NOD2
13 positive regulation of interleukin-1 beta production GO:0032731 9.56 INAVA NOD2
14 positive regulation of T-helper 1 type immune response GO:0002827 9.55 IL23R SLC11A1
15 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.54 NOD2 SLC11A1
16 response to peptidoglycan GO:0032494 9.52 INAVA IRF5
17 carnitine transport GO:0015879 9.51 SLC22A4 SLC22A5
18 positive regulation of stress-activated MAPK cascade GO:0032874 9.5 IL26 INAVA NOD2
19 protein lipidation involved in autophagosome assembly GO:0061739 9.49 ATG16L1 IRGM
20 quaternary ammonium group transport GO:0015697 9.48 SLC22A4 SLC22A5
21 carnitine transmembrane transport GO:1902603 9.46 SLC22A4 SLC22A5
22 cytokine production involved in immune response GO:0002367 9.43 INAVA NOD2
23 cytokine-mediated signaling pathway GO:0019221 9.43 DUOX2 IL10RA IL10RB IL23R IL26 IRF5
24 response to muramyl dipeptide GO:0032495 9.33 INAVA IRF5 NOD2
25 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 8.8 INAVA IRGM NOD2

Molecular functions related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.43 ABCB1 SLC22A4 SLC22A5
2 CARD domain binding GO:0050700 9.32 IRGM NOD2
3 quaternary ammonium group transmembrane transporter activity GO:0015651 9.16 SLC22A4 SLC22A5
4 carnitine transmembrane transporter activity GO:0015226 8.96 SLC22A4 SLC22A5
5 interleukin-10 receptor activity GO:0004920 8.62 IL10RA IL10RB
Sources

Sources for Crohn's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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