MCID: CRH001
MIFTS: 74

Crohn's Disease

Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Crohn's Disease

MalaCards integrated aliases for Crohn's Disease:

Name: Crohn's Disease 12 74 52 25 42 15 37 17
Crohn Disease 12 25 15 71
Pediatric Crohn's Disease 12 52 71
Enteritis 52 54 71
Crohn's Disease of Large Bowel 12 71
Granulomatous Colitis 12 52
Ileitis 52 71
Pediatric Onset Crohn's Disease 52
Crohn's Disease, Pediatric 52
Crohn's Disease of Colon 12
Enteritis, Granulomatous 25
Granulomatous Enteritis 52
Colitis, Granulomatous 25
Enteritis, Regional 25
Regional Enteritis 71
Crohn's Enteritis 25

Classifications:



External Ids:

Disease Ontology 12 DOID:8778
ICD9CM 34 555.1
MeSH 43 D003424
NCIt 49 C35211
SNOMED-CT 67 7620006
UMLS 71 C0010346 C0014335 C0020877 more

Summaries for Crohn's Disease

Genetics Home Reference : 25 Crohn disease is a complex, long-lasting (chronic) disorder that primarily affects the digestive system. This condition involves an abnormal immune response that causes excess inflammation. It most often affects the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). However, inflammation can occur in any part of the digestive system, from the mouth to the anus. The inflamed tissues become thick and swollen, and the inner surfaces of the digestive system may develop open sores (ulcers). Crohn disease most commonly appears in a person's late teens or twenties, although the disease can begin at any age. Signs and symptoms tend to flare up multiple times throughout life. The most common features of this condition are persistent diarrhea, abdominal pain and cramping, loss of appetite, weight loss, and fever. Some people with Crohn disease have blood in the stool from inflamed tissues in the intestine; over time, chronic bleeding can lead to a low number of red blood cells (anemia). In some cases, Crohn disease can also cause inflammation affecting the joints, eyes, or skin. Intestinal blockage is a common complication of Crohn disease. Blockages are caused by swelling or a buildup of scar tissue in the intestinal walls. Some affected individuals also develop fistulae, which are abnormal connections between the intestine and other tissues. Fistulae occur when ulcers break through the intestinal wall and passages form between loops of the intestine or between the intestine and nearby structures (such as the bladder, vagina, or skin). Crohn disease is one common form of inflammatory bowel disease (IBD). Another type of IBD, ulcerative colitis, also causes chronic inflammation of the intestinal lining. Unlike Crohn disease, which can affect any part of the digestive system, ulcerative colitis typically causes inflammation only in the colon.

MalaCards based summary : Crohn's Disease, also known as crohn disease, is related to ileocolitis and inflammatory bowel disease 1, and has symptoms including nausea and vomiting, abdominal pain and constipation. An important gene associated with Crohn's Disease is ENSG00000278769 (), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Tocopherol and Zinc have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An intestinal disease that involves inflammation located in intestine.

NIH Rare Diseases : 52 Crohn's disease is a type of inflammatory bowel disease (IBD) , the general name for conditions that cause inflammation in the gastrointestinal (GI) tract. Common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. Other general symptoms include feeling tired, nausea and loss of appetite, fever, and anemia . Complications of Crohn's disease may include intestinal blockage, fistulas , anal fissures , ulcers, malnutrition, and inflammation in other areas of the body. Crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. The exact cause is unknown, but is thought to be due from a combination of certain genetic variations, changes in the immune system , and the presence of bacteria in the digestive tract. Many of the major genes related to Crohn disease, including NOD2 , ATG16L1 , IL23R , and IRGM , are involved in immune system function. The disease is not inherited but it appears to run in some families because in about 15% of the cases the disease is present in more than one relative. Treatment is aimed at relieving symptoms and reducing inflammation, and may include diet and medication, but some people require surgery. Surgery often involves removal of the diseased segment of bowel (resection), the two ends of healthy bowel are then joined together (anastomosis). In about 30% of people who have surgery for Crohn's disease symptoms may come back within three years and up to 60% will have recurrence within ten years.

MedlinePlus : 42 Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory bowel disease. Crohn's can affect any area from the mouth to the anus. It often affects the lower part of the small intestine called the ileum. The cause of Crohn's disease is unknown. It may be due to an abnormal reaction by the body's immune system. It also seems to run in some families. It most commonly starts between the ages of 13 and 30. The most common symptoms are pain in the abdomen and diarrhea. Other symptoms include Bleeding from the rectum Weight loss Fever Your doctor will diagnose Crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. Crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. People with Crohn's can also have joint pain and skin problems. Children with the disease may have growth problems. There is no cure for Crohn's. Treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. Some people have long periods of remission, when they are free of symptoms. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Wikipedia : 74 Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the... more...

Related Diseases for Crohn's Disease

Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2164)
# Related Disease Score Top Affiliating Genes
1 ileocolitis 33.3 NOD2 DUOX2 ATG16L1
2 inflammatory bowel disease 1 33.1 SLC22A5 SLC22A4 NOD2 IRGM IL23R ATG16L1
3 inflammatory bowel disease 33.0 SLC22A5 SLC22A4 NOD2 LACC1 ITGA4 IRGM
4 inflammatory bowel disease 25, autosomal recessive 32.8 IL10RB IL10RA
5 ulcerative colitis 32.3 NOD2 LACC1 IRGM IRF5 INAVA IL23R
6 colitis 32.1 NOD2 LACC1 IRGM IRF5 INAVA IL23R
7 cholangitis 31.6 NOD2 HP HLA-DRB1
8 sclerosing cholangitis 31.6 NOD2 HP HLA-DRB1
9 celiac disease 1 31.5 NOD2 IL23R IL18RAP HP HLA-DRB1 ATG16L1
10 inflammatory bowel disease 5 31.5 SLC22A5 SLC22A4 NOD2 IRGM IL23R ATG16L1
11 sarcoidosis 1 31.2 NOD2 IL12RB2 HLA-DRB1
12 leprosy 3 31.1 NOD2 LACC1 IRGM IL23R HLA-DRB1
13 rheumatoid arthritis 31.1 SLC22A4 IRF5 IL23R IL10RA HP HLA-DRB1
14 inflammatory bowel disease 19 31.0 NOD2 IRGM
15 spondylarthropathy 31.0 NOD2 HP
16 inflammatory bowel disease 2 30.9 NOD2 ATG16L1
17 inflammatory bowel disease 3 30.9 NOD2 IL23R
18 inflammatory bowel disease 6 30.8 NOD2 IL23R ATG16L1
19 psoriatic arthritis 30.7 NOD2 IL23R HLA-DRB1
20 behcet syndrome 30.6 NOD2 IL23R IL12RB2 HLA-DRB1
21 lymphoproliferative syndrome, x-linked, 2 30.3 NOD2 IL10RB IL10RA
22 gastrointestinal defects and immunodeficiency syndrome 29.8 IL10RB IL10RA
23 thoraco abdominal enteric duplication 12.5
24 gastroduodenal crohn's disease 12.5
25 crohn's disease of the esophagus 12.4
26 trichohepatoenteric syndrome 1 12.3
27 enteric pattern testicular yolk sac tumor 12.2
28 diarrhea 4, malabsorptive, congenital 11.7
29 melkersson-rosenthal syndrome 11.7
30 irritable bowel syndrome 11.6
31 orofacial granulomatosis 11.6
32 ileitis 11.6
33 diarrhea 11.6
34 hirschsprung disease 1 11.5
35 short bowel syndrome 11.5
36 pyoderma gangrenosum 11.5
37 rickets 11.5
38 colorectal cancer 11.5
39 coccidiosis 11.5
40 campylobacteriosis 11.5
41 epidermolysis bullosa acquisita 11.5
42 hemorrhoid 11.5
43 keratomalacia 11.5
44 skin tag 11.5
45 visceral neuropathy, familial, autosomal dominant 11.4
46 littoral cell angioma of the spleen 11.4
47 head injury 11.4
48 visceral myopathy 11.4
49 inflammatory bowel disease 29 11.4
50 hermansky-pudlak syndrome 5 11.4

Comorbidity relations with Crohn's Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Inflammatory Bowel Disease 1
Intestinal Obstruction Protein-Energy Malnutrition
Ulcerative Colitis

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to Crohn's Disease

Symptoms & Phenotypes for Crohn's Disease

UMLS symptoms related to Crohn's Disease:


nausea and vomiting, abdominal pain, constipation, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 ABCB1 ATG16L1 HP IL10RA IL10RB IL12RB2
2 digestive/alimentary MP:0005381 9.86 ABCB1 ATG16L1 IL10RA IL10RB IL12RB2 IL23R
3 homeostasis/metabolism MP:0005376 9.8 ABCB1 ATG16L1 DUOX2 HP IL10RA IL10RB
4 immune system MP:0005387 9.44 ABCB1 ATG16L1 HP IL10RA IL10RB IL12RB2

Drugs & Therapeutics for Crohn's Disease

Drugs for Crohn's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 433)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051
3
Prucalopride Approved Phase 4 179474-81-8
4
Copper Approved, Investigational Phase 4 7440-50-8 27099
5
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
6
Risedronate Approved, Investigational Phase 4 105462-24-6 5245
7
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
8
Dimenhydrinate Approved Phase 4 523-87-5 441281
9
Linaclotide Approved Phase 4 851199-59-2 65351
10
Ondansetron Approved Phase 4 99614-02-5 4595
11
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
14
Vancomycin Approved Phase 4 1404-90-6 14969 441141
15
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
16
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
17
Ustekinumab Approved, Investigational Phase 4 815610-63-0
18
Apixaban Approved Phase 4 503612-47-3 10182969
19
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
20
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
21
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
22
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
23
Caffeine Approved Phase 4 58-08-2 2519
24
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
25
Losartan Approved Phase 4 114798-26-4 3961
26
leucovorin Approved Phase 4 58-05-9 6006 143
27
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
28
tannic acid Approved Phase 4 1401-55-4
29
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
30
Certolizumab pegol Approved Phase 4 428863-50-7
31
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
32
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
33
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
34
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
35 Tocotrienol Investigational Phase 4 6829-55-6
36 Antioxidants Phase 4
37 Tocotrienols Phase 4
38 Tocopherols Phase 4
39 Serotonin Receptor Agonists Phase 4
40 Copper Supplement Phase 4
41 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
42 Antidepressive Agents Phase 4
43 calcium channel blockers Phase 4
44 Vitamin K 1 Phase 4
45 Diphosphonates Phase 4
46 Laxatives Phase 4
47 Cathartics Phase 4
48 Histamine H1 Antagonists Phase 4
49 Polyethylene glycol 3350 Phase 4
50 Hematinics Phase 4

Interventional clinical trials:

(show top 50) (show all 1646)
# Name Status NCT ID Phase Drugs
1 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
2 Phase IV Study Comparing a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
3 Double-blind Placebo Controlled Trial of VSL#3 in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
4 Does Clinical Response Correlate With Serum Certolizumab Levels? A Prospective Open Label Trial of Adult Patients With Active Crohn's Disease (APOLLO) Unknown status NCT02597829 Phase 4 Certolizumab Pegol
5 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation Unknown status NCT01765998 Phase 4 Probiotic;Placebo
6 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
7 Efficacy and Safety of Sirolimus in the Treatment of Crohn's Disease With Stenosis Unknown status NCT02675153 Phase 4 Sirolimus;5-ASA, Prednisone, Azathioprine or Remicade
8 Santeon InflixMab biosimILAr Research A Randomized, Controlled, Double Blind, Phase 4 Noninferiority Trial to Assess Efficacy of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission. Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
9 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
10 Optimizing Response in Crohn's Disease Patients Who Have Insufficient Initial Response or Who Have Loss of Successful Response to Certolizumab Pegol (Cimzia) Induction Therapy Unknown status NCT01024647 Phase 4
11 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease Unknown status NCT01632462 Phase 4 VSL#3
12 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission: A Multi-center, Double Blinded, Randomized, Placebo Controlled Study Unknown status NCT01817426 Phase 4 Infliximab
13 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
14 The Effect of Probiotics on Bowel Disease Unknown status NCT01078935 Phase 4
15 The Effect of Prucalopride on Small Bowel Transit Time in Patients Undergoing Capsule Endoscopy: A Randomized Controlled Trial Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
16 A Randomized, Controlled, Single-blind Study of Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
17 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
18 Anemia Treatment in Inflammatory Bowel Disease: Predictive Factors of Response to Oral Iron Treatment Unknown status NCT02760940 Phase 4 oral liposomal iron
19 Bacteria and Cytokines as Factors Modulating Visceral Afferent Processing in Irritable Bowel Syndrome: Manipulation of Intestinal Bacteria and Mucosal Cytokines by Probiotic Therapy and the Effect on Visceral Hypersensitivity Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
20 Maintenance of Vitamin D Sufficiency With Oral Vitamin D Supplementation in Malaysian Women of Malay and Indian Ethnicity With Post Menopausal Osteoporosis Unknown status NCT02389179 Phase 4 Vitamin D3
21 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
22 Pediatric Crohn's Disease AdalImumab Level-based Optimization Treatment (PAILOT) Trial Completed NCT02256462 Phase 4 Adalimumab
23 Vitamin D and Immunomodulation: Effects in Crohn's Disease Completed NCT01369667 Phase 4
24 Rapidity of Onset of Response to Adalimumab in Luminal Crohn's Disease (RAPIDA Study) Completed NCT02148718 Phase 4
25 Vitamin D and Its Effects on Inflammation and Intestinal Permeability in Crohn's Disease in Remission Completed NCT01792388 Phase 4
26 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
27 A Randomized, Single Blinded, Controlled, Multi Center Phase 4 Study for Induction of Remission in Active Pediatric Crohn's Disease, Using 2 Months Antibiotic Course of Azithromycin Combined With Metronidazole vs. Metronidazole Alone. Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
28 Serological Response to Pneumococcal Vaccination in Crohn's Disease: A Prospective Multicenter Study Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
29 A Phase III, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Antegren™ (Natalizumab) in Crohn's Disease Subjects Who Have Previously Participated in Antegren Crohn's Disease Studies Completed NCT00280956 Phase 4 natalizumab
30 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
31 A Pilot Study to Evaluate the Applicability of the Crohn's Disease Endoscopy Index of Severity to Data Obtained by the Colonic Capsule Endoscopy in Ileocolonic Crohn's Disease Completed NCT01183845 Phase 4
32 The Effect of Vitamin K Supplementation on Bone Health Indices in Adult Crohn's Disease Completed NCT01235325 Phase 4
33 A RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP STUDY TO EVALUATE THE SAFETY AND EFFICACY OF SWITCHING FROM INNOVATOR INFLIXIMAB TO BIOSIMILAR INFLIXIMAB COMPARED WITH CONTINUED TREATMENT WITH INNOVATOR INFLIXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, PSORIATIC ARTHRITIS, ULCERATIVE COLITIS, CROHN'S DISEASE AND CHRONIC PLAQUE PSORIASIS THE NOR-SWITCH STUDY Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
34 A Randomized, Data Collection Program To Determine the Efficacy and Safety of Risedronate (Actonel) Therapy Plus Calcium and Vitamin D Supplementation Versus Placebo Plus Calcium and Vitamin D Supplementation in the Treatment of Low Bone Mineral Density in Crohn's Disease Patients Completed NCT01215890 Phase 4 risedronate;placebo
35 Effect of Early Prescription of Immunosuppressants on First Three-year Course of Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
36 A Randomized Controlled Trial Investigating Tailored Treatment With Infliximab for Active Luminal Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
37 The Ideal Management of Crohn's Disease: Top Down Versus Step Up Strategies. A Prospective Controlled Trial in the Benelux Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
38 Endoscopic Detection of Small Bowel Dysplasia and Cancer in Patients With Jejuna or Ileal Crohn Disease : Prospective Study in a Cohort of High Risk Patients Completed NCT01180452 Phase 4
39 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy (the ICE Study) Completed NCT01181765 Phase 4
40 A Cluster Randomized Controlled Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
41 An Open-Label, Multicenter and Open Enrollment Model, Postmarketing, Milk-Only Lactation Study to Assess Concentration of Vedolizumab in Breast Milk of Lactating Women With Active Ulcerative Colitis or Crohn's Disease Who Are Receiving Vedolizumab Therapeutically Completed NCT02559713 Phase 4 Vedolizumab
42 Multicentre, Controlled, Randomised, Open, Cross-over Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tbl. 500 mg in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
43 Microarray Analysis of Peripheral Blood and Tissues of Patients With Immune Mediated Inflammatory Diseases Completed NCT00462072 Phase 4 Infliximab
44 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
45 Immunogenicity of Hepatitis A Vaccine in Patients With Inflammatory Bowel Disease Completed NCT01341808 Phase 4
46 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease: a Placebo-controlled Randomized Trial Completed NCT02010762 Phase 4 Vitamin D;Placebo
47 A Randomized Double-Blind Phase 4 Study to Evaluate the Safety and Proportion of Subjects With Fistula Healing in 2 Dose Regimens of Entyvio (Vedolizumab IV) in the Treatment of Fistulizing Crohn's Disease (ENTERPRISE) Completed NCT02630966 Phase 4 Vedolizumab;Placebo
48 Modulation of Immune Function by Parenteral Fish Oil in Patients With Crohn's Disease and High Inherent Tumor Necrosis Factor-alpha Production: a Randomized, Single Blinded, Cross-over Study Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
49 Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
50 A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL) Completed NCT01804166 Phase 4 Infliximab;Golimumab

Search NIH Clinical Center for Crohn's Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


aminosalicylic acid
Azathioprine
Cholecalciferol
natalizumab
Opium
OPIUM ALKALOIDS HYDROCHLORIDE
OPIUM, POWDERED
paregoric
Thalidomide

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Crohn's Disease cell therapies at LifeMap Discovery.

Genetic Tests for Crohn's Disease

Anatomical Context for Crohn's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Disease:

19
Intestine

MalaCards organs/tissues related to Crohn's Disease:

40
Colon, Small Intestine, Bone, T Cells, Testes, Skin, Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Crohn's Disease

Articles related to Crohn's Disease:

(show top 50) (show all 33448)
# Title Authors PMID Year
1
Mesenchymal Stem Cell Therapy Can Transcend Perianal Crohn's Disease: How Colorectal Surgeons Can Help in the Coronavirus Disease 2019 Crisis. 42 61
32251143 2020
2
Beyond Crohn Disease: Current Role of Radiologists in Diagnostic Imaging Assessment of Inflammatory Bowel Disease Transitioning from Pediatric to Adult Patients. 61 42
32276701 2020
3
PLACEBO USE IN THE CONTEXT OF INFLAMMATORY BOWEL DISEASE CLINICAL TRIALS. 42
32294741 2020
4
Virulence determinants and genetic diversity of adherent-invasive Escherichia coli (AIEC) strains isolated from patients with Crohn's disease. 61
32360521 2020
5
Crohn's disease and environmental contamination: Current challenges and perspectives in exposure evaluation. 61
32325248 2020
6
Risk of colorectal cancer in inflammatory bowel diseases. 61
31112753 2020
7
Variation of faecal calprotectin level within the first three months after bowel resection is predictive of endoscopic postoperative recurrence in Crohn's disease. 61
32444250 2020
8
Ustekinumab is associated with superior effectiveness outcomes compared to vedolizumab in Crohn's disease patients with prior failure to anti-TNF treatment. 61
32441396 2020
9
Population Pharmacokinetics and Pharmacodynamics of Ontamalimab (SHP647), a Fully Human Monoclonal Antibody Against Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1), in Patients With Ulcerative Colitis or Crohn's Disease. 61
32119128 2020
10
Postoperative Crohn's disease management. 61
32304384 2020
11
Patterns of Primary, Specialty, Urgent Care, and Emergency Department Care in Children With Inflammatory Bowel Diseases. 61
32142000 2020
12
Use of Narrative Concepts in Electronic Health Records to Validate Associations Between Genetic Factors and Response to Treatment of Inflammatory Bowel Diseases. 61
31404664 2020
13
Mesh Repair in Crohn's Disease: A Case-Matched Multicenter Study in 234 Patients. 61
32107592 2020
14
A case-control study of HLA alleles in Brazilian patients with Melkersson-Rosenthal syndrome. 61
32045706 2020
15
Long-term Results of the Side-to-side Isoperistaltic Strictureplasty in Crohn Disease: 25-year Follow-up and Outcomes. 61
30720502 2020
16
Emerging Roles of PET/MR in the Pediatric Hospital. 61
32498981 2020
17
The Safety and Feasibility of a New Through-the-scope Balloon-assisted Enteroscopy in Children. 61
32187142 2020
18
COVID-19 infection in Crohn's disease under treatment with adalimumab. 61
32312788 2020
19
Strictures in Crohn's Disease: From Pathophysiology to Treatment. 61
32279173 2020
20
Levels of Vitamin D Are Low After Crohn's Disease Is Established But Not Before. 61
31589971 2020
21
Defining the phenotype, pathogenesis and treatment of Crohn's disease associated spondyloarthritis. 61
32367294 2020
22
Within-network brain connectivity in Crohn's disease patients with gadolinium deposition in the cerebellum. 61
32246178 2020
23
Strictureplasty for Crohn's disease of the small bowel in the biologic era: long-term outcomes and risk factors for recurrence. 61
32306308 2020
24
Systematic Review and External Validation of Prediction Models Based on Symptoms and Biomarkers for Identifying Endoscopic Activity in Crohn's Disease. 61
31881273 2020
25
Effectiveness of ustekinumab dose escalation in Crohn's disease patients with insufficient response to standard-dose subcutaneous maintenance therapy. 61
32412134 2020
26
Body Composition Using Air Displacement Plethysmography in Children With Inflammatory Bowel Disease. 61
32141991 2020
27
Extraintestinal Manifestations Are Associated With Disease Severity in Pediatric Onset Inflammatory Bowel Disease. 61
32187141 2020
28
Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn's Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways. 61
32545398 2020
29
Effect of Concomitant Therapy With Steroids and Tumor Necrosis Factor Antagonists for Induction of Remission in Patients With Crohn's Disease: a Systematic Review and Pooled Meta-analysis. 61
32569749 2020
30
Ozanimod induction therapy for patients with moderate to severe Crohn's disease: a single-arm, phase 2, prospective observer-blinded endpoint study. 61
32553149 2020
31
Correction to: Normalization of C-Reactive Protein Predicts Better Outcome in Patients With Crohn's Disease With Mucosal Healing and Deep Remission. 61
32467408 2020
32
Acute kidney injury: an unexpected Isoniazid-related adverse event in a patient with Crohn's disease receiving prophylactic treatment for latent tuberculosis. 61
32505573 2020
33
A virtual clinic increases anti-TNF dose intensification success via a treat-to-target approach compared with standard outpatient care in Crohn's disease. 61
32379358 2020
34
Early Transmural Response Assessed Using Magnetic Resonance Imaging Could Predict Sustained Clinical Remission and Prevent Bowel Damage in Patients with Crohn's Disease Treated with Anti-Tumour Necrosis Factor Therapy. 61
32533769 2020
35
Profiling of Human Circulating Dendritic Cells and Monocyte Subsets Discriminates Between Type and Mucosal Status in Patients With Inflammatory Bowel Disease. 61
32548643 2020
36
Effectiveness of Switching from Reference Product Infliximab to Infliximab-Dyyb in Patients with Inflammatory Bowel Disease in an Integrated Healthcare System in the United States: A Retrospective, Propensity Score-Matched, Non-Inferiority Cohort Study. 61
32103457 2020
37
microRNA in inflammatory bowel disease at a glance. 61
32558695 2020
38
The Treatment of Pediatric Inflammatory Bowel Disease with Biologic Therapies. 61
32542562 2020
39
Pulmonary Manifestations in Adolescents With Inflammatory Bowel Disease. 61
32146830 2020
40
Surgery for Inflammatory Bowel Disease in the Era of Biologics. 61
32253646 2020
41
Is Psoriasis Treatment a Risk Factor for Inflammatory Bowel Disease? 61
32514931 2020
42
Metastatic Crohn's disease. 61
31506198 2020
43
Author Correction: Crohn's disease. 61
32561754 2020
44
Diagnosis and Outcome of Oesophageal Crohn's Disease. 61
31837220 2020
45
Endoscopic management of stricturing Crohn's disease. 61
32537911 2020
46
Mesenchymal stem cells in perianal Crohn's disease. 61
32488549 2020
47
Epstein-Barr Virus-related mucocutaneous ulcer lymphoma associated with Crohn's disease, treated with monoclonal antibody anti-CD30. 61
32577242 2020
48
Role of Thiopurines in Pediatric Inflammatory Bowel Diseases: A Real-Life Prospective Cohort Study. 61
32443042 2020
49
Novel XIAP mutation causing enhanced spontaneous apoptosis and disturbed NOD2 signalling in a patient with atypical adult-onset Crohn's disease. 61
32514016 2020
50
Targeting epithelium-expressed sialyl Lewis glycans improves colonic mucosal wound healing and protects against colitis. 61
32427587 2020

Variations for Crohn's Disease

Copy number variations for Crohn's Disease from CNVD:

7 (show all 25)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 19625 1 150839831 150840116 Deletion and duplication LCE3C Crohn''s disease
2 19631 1 150852910 150853198 Deletion and duplication LCE3B Crohn''s disease
3 71426 12 69818942 132349534 Copy number Crohn''s disease
4 112709 17 40930407 78774742 Copy number Crohn''s disease
5 139336 2 179004449 242951149 Copy number Crohn''s disease
6 194979 5 147200000 152100000 Low copy numbers IRGM Crohn''s disease
7 195288 5 149800000 152700000 Copy number Crohn''s disease
8 195354 5 150157836 180857866 Copy number Crohn''s disease
9 195374 5 150183562 180857866 Copy number Crohn''s disease
10 195384 5 150207878 150208422 Deletion IRGM Crohn''s disease
11 195385 5 150207878 150208422 Deletion and duplication IRGM Crohn''s disease
12 210788 6 31416574 170899992 Copy number Crohn''s disease
13 211338 6 32582950 170899992 Copy number Crohn''s disease
14 211384 6 32609209 170899992 Copy number Crohn''s disease
15 211736 6 336751 356443 Copy number IRF4 Crohn''s disease
16 230702 8 1 12700000 Copy number Crohn''s disease
17 241420 8 6200000 12700000 Copy number HBD-2 Crohn''s disease
18 241431 8 6200000 12700000 Duplication DEFB103 Crohn''s disease
19 241433 8 6200000 12700000 Duplication DEFB4 Crohn''s disease
20 241436 8 6200000 12700000 Duplication SPAG11 Crohn''s disease
21 241467 8 6200000 12700000 Low copy numbers Crohn''s disease
22 242030 8 6873390 6875823 Copy number Crohn''s disease
23 242532 8 7259842 7791647 Copy number DEFB4 Crohn''s disease
24 242534 8 7259842 7791647 Deletion and duplication DEFB4 Crohn''s disease
25 242535 8 7259842 7791647 Deletion and duplication HBD-2 Crohn''s disease

Expression for Crohn's Disease

LifeMap Discovery
Genes differentially expressed in tissues of Crohn's Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 REG1A regenerating islet-derived 1 alpha Colon + 4.42 0.002
2 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 4.02 0.000
3 REG1B regenerating islet-derived 1 beta Colon + 3.99 0.008
4 LCN2 lipocalin 2 Colon + 3.90 0.000
5 REG3A regenerating islet-derived 3 alpha Colon + 3.74 0.026
6 CXCL11 chemokine (C-X-C motif) ligand 11 Colon + 3.70 0.016
7 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.60 0.000
8 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.50 0.004
9 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.49 0.029
10 S100A8 S100 calcium binding protein A8 Colon + 3.04 0.017
Search GEO for disease gene expression data for Crohn's Disease.

Pathways for Crohn's Disease

Pathways related to Crohn's Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 NOD2 ITGA4 IRF5 IL23R IL18RAP IL12RB2
2
Show member pathways
12.97 NOD2 IRF5 IL23R IL18RAP IL12RB2 IL10RB
3
Show member pathways
12.33 IL23R IL18RAP IL10RB IL10RA
4
Show member pathways
12.21 IL23R IL12RB2 IL10RB IL10RA
5
Show member pathways
11.97 NOD2 IL23R IL18RAP IL12RB2 IL10RB HLA-DRB1
6 11.92 NOD2 IL10RB IL10RA HLA-DRB1
7
Show member pathways
11.9 ITGA4 IL23R IL12RB2 IL10RB IL10RA
8
Show member pathways
11.83 ITGA4 IRGM IL10RB IL10RA HLA-DRB1
9
Show member pathways
11.71 IL18RAP IL12RB2 HLA-DRB1
10
Show member pathways
11.66 IL23R IL18RAP IL12RB2
11 11.48 ITGA4 IL23R IL12RB2
12 11.39 ITGA4 IL23R IL12RB2 IL10RB IL10RA ATG16L1

GO Terms for Crohn's Disease

Cellular components related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.13 SLC22A5 SLC22A4 NOD2 ITGA4 IRGM IL23R
2 cell surface GO:0009986 9.63 NOD2 ITGA4 HLA-DRB1 DUOX2 CEACAM6 ABCB1
3 plasma membrane GO:0005886 9.47 SLC22A5 SLC22A4 NOD2 ITGA4 IRGM IL23R
4 apical plasma membrane GO:0016324 9.35 SLC22A5 SLC22A4 DUOX2 CEACAM6 ABCB1

Biological processes related to Crohn's Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.96 NOD2 IRGM IRF5 INAVA IL23R
2 immune system process GO:0002376 9.8 NOD2 IRGM IRF5 INAVA IL23R HP
3 defense response GO:0006952 9.78 NOD2 IRGM HP DUOX2
4 positive regulation of stress-activated MAPK cascade GO:0032874 9.58 NOD2 INAVA
5 positive regulation of interleukin-1 beta production GO:0032731 9.57 NOD2 INAVA
6 positive regulation of interleukin-17 production GO:0032740 9.55 NOD2 IL23R
7 detection of bacterium GO:0016045 9.54 NOD2 HLA-DRB1
8 interferon-gamma production GO:0032609 9.52 IL18RAP IL12RB2
9 response to peptidoglycan GO:0032494 9.51 IRF5 INAVA
10 carnitine transport GO:0015879 9.49 SLC22A5 SLC22A4
11 protein lipidation involved in autophagosome assembly GO:0061739 9.46 IRGM ATG16L1
12 quaternary ammonium group transport GO:0015697 9.43 SLC22A5 SLC22A4
13 cytokine-mediated signaling pathway GO:0019221 9.43 IRF5 IL23R IL12RB2 IL10RB IL10RA DUOX2
14 cytokine production involved in immune response GO:0002367 9.4 NOD2 INAVA
15 pattern recognition receptor signaling pathway GO:0002221 9.37 NOD2 INAVA
16 response to muramyl dipeptide GO:0032495 9.33 NOD2 IRF5 INAVA
17 carnitine transmembrane transport GO:1902603 9.32 SLC22A5 SLC22A4
18 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 8.8 NOD2 IRGM INAVA

Molecular functions related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 SLC22A5 SLC22A4 NOD2 LACC1 ITGA4 IRGM
2 CARD domain binding GO:0050700 9.4 NOD2 IRGM
3 xenobiotic transmembrane transporter activity GO:0042910 9.37 SLC22A5 ABCB1
4 quaternary ammonium group transmembrane transporter activity GO:0015651 9.32 SLC22A5 SLC22A4
5 carnitine transmembrane transporter activity GO:0015226 9.26 SLC22A5 SLC22A4
6 interleukin-10 receptor activity GO:0004920 9.16 IL10RB IL10RA
7 cytokine receptor activity GO:0004896 8.92 IL23R IL12RB2 IL10RB IL10RA

Sources for Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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