MCID: CRP002
MIFTS: 43

Croup

Categories: Immune diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Croup

MalaCards integrated aliases for Croup:

Name: Croup 12 77 44 45 15 17 74
Laryngotracheobronchitis 12 74
Acute Laryngotracheobronchitis 12
Acute Obstructive Laryngitis 12
Croup Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9395
ICD9CM 36 464.4
MeSH 45 D003440
NCIt 51 C26735
SNOMED-CT 69 71186008
ICD10 34 J05.0

Summaries for Croup

MedlinePlus : 44 Croup is an inflammation of the vocal cords (larynx) and windpipe (trachea). It causes difficulty breathing, a barking cough, and a hoarse voice. The cause is usually a virus, often parainfluenza virus. Other causes include allergies and reflux. Croup often starts out like a cold. But then the vocal cords and windpipe become swollen, causing the hoarseness and the cough. There may also be a fever and high-pitched noisy sounds when breathing. The symptoms are usually worse at night, and last for about three to five days. Children between the ages of 6 months and 3 years have the highest risk of getting croup. They may also have more severe symptoms. Croup is more common in the fall and winter. Most cases of viral croup are mild and can be treated at home. Rarely, croup can become serious and interfere with your child's breathing. If you are worried about your child's breathing, call your health care provider right away.

MalaCards based summary : Croup, also known as laryngotracheobronchitis, is related to diphtheria and tracheitis, and has symptoms including stridor, snoring and inspiratory stridor. An important gene associated with Croup is CD14 (CD14 Molecule), and among its related pathways/superpathways is Phagosome. The drugs Dexamethasone and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include trachea, bone and breast.

Disease Ontology : 12 A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

Wikipedia : 77 Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused... more...

Related Diseases for Croup

Diseases related to Croup via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 diphtheria 11.5
2 tracheitis 11.5
3 epiglottitis 11.1
4 asthma 10.4
5 bronchiolitis 10.4
6 laryngotracheitis 10.3
7 influenza 10.3
8 measles 10.3
9 pneumonia 10.2
10 pulmonary edema 10.2
11 laryngitis 10.2
12 bronchitis 10.2
13 lymphoma 10.2
14 ige responsiveness, atopic 10.1
15 gastroesophageal reflux 10.0
16 laryngomalacia 10.0
17 arthritis 10.0
18 myocarditis 10.0
19 herpes simplex 10.0
20 sudden infant death syndrome 10.0
21 peripheral t-cell lymphoma 10.0
22 otitis media 9.9
23 cystic fibrosis 9.9
24 acute insulin response 9.9
25 hemangioma 9.9
26 scoliosis 9.9
27 cardiac arrest 9.9
28 lymphoproliferative syndrome 9.9
29 salmonellosis 9.9
30 legionnaires' disease 9.9
31 chlamydia 9.9
32 esophagitis 9.9
33 guillain-barre syndrome 9.9
34 toxic shock syndrome 9.9
35 candidiasis 9.9
36 pharyngitis 9.9
37 subglottic angioma 9.9
38 cleft lip 9.9
39 haemophilus influenzae 9.8

Graphical network of the top 20 diseases related to Croup:



Diseases related to Croup

Symptoms & Phenotypes for Croup

UMLS symptoms related to Croup:


stridor, snoring, inspiratory stridor, coughing

Drugs & Therapeutics for Croup

Drugs for Croup (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
4
Fluticasone Approved, Experimental Phase 4,Phase 3 90566-53-3 62924
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6
Racepinephrine Approved Phase 4 329-65-7 838
7
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 113775-47-6 5311068 68602
8 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
9 HIV Protease Inhibitors Phase 4,Phase 2
10 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
12 Hormone Antagonists Phase 4,Phase 3,Phase 2
13 Hormones Phase 4,Phase 3,Phase 2
14
protease inhibitors Phase 4,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
16 glucocorticoids Phase 4,Phase 3,Phase 2
17 Autonomic Agents Phase 4,Phase 3,Phase 2
18 Antiemetics Phase 4,Phase 3,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
20 BB 1101 Phase 4,Phase 2
21 Sympathomimetics Phase 4
22 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
23 Adrenergic beta-2 Receptor Agonists Phase 4
24 Bronchodilator Agents Phase 4,Phase 3
25 Adrenergic Agents Phase 4,Phase 3
26 Dermatologic Agents Phase 4,Phase 3
27 Adrenergic beta-Agonists Phase 4
28 Fluticasone-Salmeterol Drug Combination Phase 4
29
Salmeterol xinafoate Phase 4 94749-08-3 56801
30 Respiratory System Agents Phase 4,Phase 3
31 Anti-Allergic Agents Phase 4,Phase 3
32 Anti-Asthmatic Agents Phase 4,Phase 3
33 Adrenergic Agonists Phase 4,Phase 3
34 Adrenergic alpha-Agonists Phase 4,Phase 3
35 Vasoconstrictor Agents Phase 4
36 Mydriatics Phase 4
37 Epinephryl borate Phase 4
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
39 Analgesics, Non-Narcotic Phase 4,Phase 3
40 Analgesics Phase 4,Phase 3
41 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
42 Hypnotics and Sedatives Phase 4,Phase 3
43 Central Nervous System Depressants Phase 4,Phase 3
44
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
45
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
46
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
47
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
48
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
49
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
50
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
2 Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies. Completed NCT00370591 Phase 4 Salmeterol/fluticasone propionate and fluticasone propionate
3 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Recruiting NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
4 Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup Recruiting NCT03705273 Phase 4 Dexamethasone IV for PO;Dexamethasone crushed tablets
5 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Terminated NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
6 A Trial of Point of Care Information in Ambulatory Pediatrics Completed NCT00368823 Phase 3
7 A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children Completed NCT01218308 Phase 3
8 Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy Recruiting NCT03211871 Phase 3 Dexmedetomidine;Normal Saline Flush, 0.9% Injectable Solution_#1
9 Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART) Active, not recruiting NCT00920621 Phase 3
10 Management of Recurrent Croup Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
11 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
12 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
13 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
14 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children Completed NCT00767416 Phase 1, Phase 2
15 Phase IIb Study Evaluating Immunogenic Chemotherapy Combined With Ipilimumab and Nivolumab in Breast Cancer Recruiting NCT03409198 Phase 2 Ipilimumab;Nivolumab;Pegylated liposomal doxorubicin;Cyclophosphamide
16 Aprepitant Triple Therapy Caused Chemotherapy Induced Nausea And Vomiting In Gastrointestinal Tumors Recruiting NCT03674294 Phase 2 Aprepitant;Palonosetron;Dexamethasone;Placebo Oral Tablet
17 Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable? Active, not recruiting NCT03204760 Phase 2 Dexamethasone 8Mg Solution for Injection;Prednisolone Oral, Per 5 Mg
18 Safety of and Immune Response to Recombinant Live-Attenuated Parainfluenza Type 1 Virus Vaccine Completed NCT00641017 Phase 1
19 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
20 A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers Recruiting NCT00186927 Phase 1
21 , "Mucosal Injury During Nasotracheal Intubation for Dental Procedures in Children-does the Tube Design Matter?" Unknown status NCT02517294 Not Applicable
22 Diagnosing Respiratory Disease in Children Using Cough Sounds 2 Completed NCT03392363
23 Diagnosing Respiratory Disease in Children Using Cough Sounds Completed NCT02973282
24 A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children Completed NCT00626808 No Intervention
25 Re-evaluation of Blind Intubation Through the Air-Q Intubating Laryngeal Airway Completed NCT03778762 Not Applicable
26 Supplement to Hospital to Home Outcomes Completed NCT03224130 Not Applicable
27 Hospital to Home Outcomes Completed NCT02081846 Not Applicable
28 Comparison Between Two Endotracheal Tube Cuff Inflation Methods Recruiting NCT03902756 Not Applicable
29 Sunface Mirroring RCT in Brazil Not yet recruiting NCT03178240 Not Applicable
30 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849 Not Applicable

Search NIH Clinical Center for Croup

Cochrane evidence based reviews: croup

Genetic Tests for Croup

Anatomical Context for Croup

MalaCards organs/tissues related to Croup:

42
Trachea, Bone, Breast, Lung, Liver, Kidney, Testes

Publications for Croup

Articles related to Croup:

(show top 50) (show all 807)
# Title Authors Year
1
Automatic Croup Diagnosis Using Cough Sound Recognition. ( 29993458 )
2019
2
Do Glucocorticoids Improve Symptoms and Reduce Return Visits or Admission Rates Among Children With Croup? ( 30529111 )
2019
3
Animal Bites, Fall Risk, Croup, Scoliosis, Recurrent VTE, Postpartum Perineal Pain. ( 30633475 )
2019
4
Management and outcomes of patients presenting to the emergency department with croup: Can we identify which patients can safely be discharged from the emergency department? ( 30779245 )
2019
5
Efficacy of low-dose nebulized epinephrine as treatment for croup: A randomized, placebo-controlled, double-blind trial. ( 30878411 )
2019
6
Croup Admissions: Can We Shrink the Elephant in the Room? ( 30925569 )
2019
7
Hospital Course of Croup After Emergency Department Management. ( 30988017 )
2019
8
Croup. ( 31012936 )
2019
9
Corrections to "Automatic Croup Diagnosis Using Cough Sound Recognition". ( 31021746 )
2019
10
Subglottic hemangioma masquerading as croup and treated successfully with oral propranolol. ( 31031345 )
2019
11
Rebound stridor in children with croup after nebulised adrenaline: does it really exist? ( 31031839 )
2019
12
Glucocorticoids for Croup in Children. ( 31033996 )
2019
13
Predictors of Symptom Rebound in Critically Ill Patients With Croup. ( 31076458 )
2019
14
Croup: Diagnosis and Management. ( 29763253 )
2018
15
Croup: What You Should Know. ( 29763268 )
2018
16
Uncommon presentation of a common disease: influenza A presenting as adult croup . ( 29866674 )
2018
17
Air pollution is associated with incidence of viral croup among children living in Kraków area, Poland. ( 30079902 )
2018
18
Glucocorticoids for croup in children. ( 30133690 )
2018
19
Safety and utility of direct laryngoscopy and bronchoscopy in patients hospitalized with croup. ( 30138522 )
2018
20
Association of childhood croup and increased incidence of airway hyperreactivity in adulthood. ( 30159343 )
2018
21
Not All Stridor Is Croup. ( 30256321 )
2018
22
High rates of subglottic stenosis seen in African-American children admitted with severe croup to hospitals in the United States between 2003 and 2013. ( 30261993 )
2018
23
Heliox for croup in children. ( 30371952 )
2018
24
Prehospital dexamethasone administration in children with croup: a medical record review. ( 30410413 )
2018
25
Failure of Outpatient Management With Different Observation Times After Racemic Epinephrine for Croup. ( 29034735 )
2018
26
Comparison of the Effect of Cold Drink and Dexamethasone, and their Combined Effect on Children with Croup. ( 29100262 )
2018
27
Prognostic factors and importance of recognition of adult croup. ( 29310492 )
2018
28
Prenatal phthalate exposure was associated with croup in Swedish infants. ( 29385277 )
2018
29
Acute management of croup in the emergency department. ( 29532807 )
2017
30
A Narrowing Diagnosis: A Rare Cause of Adult Croup and Literature Review. ( 28163937 )
2017
31
Variation in Inpatient Croup Management and Outcomes. ( 28292873 )
2017
32
Endogenous Glucocorticoid Response to Single-Dose Dexamethasone for Croup in Children: A Pharmacodynamic Study. ( 28398936 )
2017
33
Effects of pre-education combined with a simulation for caring for children with croup on senior nursing students. ( 28436091 )
2017
34
Westley score and clinical factors in predicting the outcome of croup in the pediatric emergency department. ( 28556543 )
2017
35
What is the effectiveness of systemic corticosteroids in children with croup? ( 28622285 )
2017
36
Mistaken Identity: Asthma and Croup in a Previously Healthy 9-Year-Old Male. ( 28777267 )
2017
37
Association of croup with asthma in children: A cohort study. ( 28858086 )
2017
38
Stridor is not always croup: infantile haemangioma in the airway. ( 28899875 )
2017
39
Management of Croup in the Emergency Department: The Role of Multidose Nebulized Epinephrine. ( 28953096 )
2017
40
Cough sound analysis for diagnosing croup in pediatric patients using biologically inspired features. ( 29060916 )
2017
41
Calculated decisions: Westley croup score ( 29115814 )
2017
42
A Systematic Review and Comprehensive Critical Analysis Examining the Use of Prednisolone for the Treatment of Mild to Moderate Croup. ( 29290883 )
2017
43
Are cytokines and cortisol important predictors for the severity of pediatric croup: A case control study. ( 29376573 )
2017
44
Invasive Aspergillus Laryngotracheobronchitis in an Adult with Primary CNS Lymphoma. ( 28213800 )
2017
45
Steeple sign and acute laryngotracheobronchitis. ( 29025139 )
2017
46
Use of laboratory and administrative data to understand the potential impact of human parainfluenza virus 4 on cases of bronchiolitis, croup, and pneumonia in Alberta, Canada. ( 27514690 )
2016
47
Efficacy of nebulized L-epinephrine for treatment of croup: a randomized, double-blind study. ( 26463007 )
2016
48
Croup. ( 26776546 )
2016
49
The role of larygotracheal reconstruction in the management of recurrent croup in patients with subglottic stenosis. ( 26857320 )
2016
50
Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child. ( 26889375 )
2016

Variations for Croup

Expression for Croup

Search GEO for disease gene expression data for Croup.

Pathways for Croup

Pathways related to Croup according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 ATP6AP1 CD14

GO Terms for Croup

Molecular functions related to Croup according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rab GTPase binding GO:0017137 8.62 ATP6AP1 RIMS2

Sources for Croup

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....