CROUP
MCID: CRP002
MIFTS: 42

Croup (CROUP)

Categories: Immune diseases, Oral diseases, Respiratory diseases

Aliases & Classifications for Croup

MalaCards integrated aliases for Croup:

Name: Croup 12 76 43 44 15 73
Laryngotracheobronchitis 12 73
Acute Laryngotracheobronchitis 12
Acute Obstructive Laryngitis 12
Croup Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9395
ICD10 33 J05.0
ICD9CM 35 464.4
MeSH 44 D003440
NCIt 50 C26735
SNOMED-CT 68 71186008

Summaries for Croup

MedlinePlus : 43 Croup is an inflammation of the vocal cords (larynx) and windpipe (trachea). It causes difficulty breathing, a barking cough, and a hoarse voice. The cause is usually a virus, often parainfluenza virus. Other causes include allergies and reflux. Croup often starts out like a cold. But then the vocal cords and windpipe become swollen, causing the hoarseness and the cough. There may also be a fever and high-pitched noisy sounds when breathing. The symptoms are usually worse at night, and last for about three to five days. Children between the ages of 6 months and 3 years have the highest risk of getting croup. They may also have more severe symptoms. Croup is more common in the fall and winter. Most cases of viral croup are mild and can be treated at home. Rarely, croup can become serious and interfere with your child's breathing. If you are worried about your child's breathing, call your health care provider right away.

MalaCards based summary : Croup, also known as laryngotracheobronchitis, is related to diphtheria and tracheitis, and has symptoms including stridor, inspiratory stridor and snoring. An important gene associated with Croup is CD14 (CD14 Molecule), and among its related pathways/superpathways is Phagosome. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include trachea, bone and lung.

Disease Ontology : 12 A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

Wikipedia : 76 Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused... more...

Related Diseases for Croup

Diseases related to Croup via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 diphtheria 11.5
2 tracheitis 11.5
3 epiglottitis 11.1
4 asthma 10.4
5 bronchiolitis 10.4
6 laryngotracheitis 10.3
7 pneumonia 10.2
8 influenza 10.2
9 measles 10.2
10 pulmonary edema 10.2
11 laryngitis 10.2
12 bronchitis 10.2
13 viral infectious disease 10.2
14 lymphoma 10.1
15 gastroesophageal reflux 10.0
16 laryngomalacia 10.0
17 arthritis 10.0
18 myocarditis 10.0
19 herpes simplex 10.0
20 sudden infant death syndrome 10.0
21 peripheral t-cell lymphoma 10.0
22 otitis media 9.9
23 cystic fibrosis 9.9
24 salmonellosis 9.9
25 chlamydia 9.9
26 esophagitis 9.9
27 toxic shock syndrome 9.9
28 candidiasis 9.9
29 pharyngitis 9.9
30 cleft lip 9.9

Graphical network of the top 20 diseases related to Croup:



Diseases related to Croup

Symptoms & Phenotypes for Croup

UMLS symptoms related to Croup:


stridor, inspiratory stridor, snoring, coughing

Drugs & Therapeutics for Croup

Drugs for Croup (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Fluticasone Approved, Experimental Phase 4,Phase 3 90566-53-3 62924
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 113775-47-6 68602 5311068
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
9 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
10 Hormones Phase 4,Phase 3,Phase 2
11 BB 1101 Phase 4,Phase 2
12 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
13 HIV Protease Inhibitors Phase 4,Phase 2
14 Antiemetics Phase 4,Phase 3,Phase 2
15 Hormone Antagonists Phase 4,Phase 3,Phase 2
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
17
protease inhibitors Phase 4,Phase 2
18 glucocorticoids Phase 4,Phase 3,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
20 Autonomic Agents Phase 4,Phase 3,Phase 2
21 Sympathomimetics Phase 4
22 Respiratory System Agents Phase 4,Phase 3
23 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
24 Adrenergic beta-Agonists Phase 4
25
Salmeterol xinafoate Phase 4 94749-08-3 56801
26 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
27 Bronchodilator Agents Phase 4,Phase 3
28 Anti-Allergic Agents Phase 4,Phase 3
29 Adrenergic Agents Phase 4,Phase 3
30 Adrenergic Agonists Phase 4,Phase 3
31 Adrenergic beta-2 Receptor Agonists Phase 4
32 Anti-Asthmatic Agents Phase 4,Phase 3
33 Dermatologic Agents Phase 4,Phase 3
34 Vasoconstrictor Agents Phase 4
35 Mydriatics Phase 4
36 Epinephryl borate Phase 4
37 Adrenergic alpha-Agonists Phase 4,Phase 3
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
39 Analgesics, Non-Narcotic Phase 4,Phase 3
40 Analgesics Phase 4,Phase 3
41 Central Nervous System Depressants Phase 4,Phase 3
42 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
43 Hypnotics and Sedatives Phase 4,Phase 3
44
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
45
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
46
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
47
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
48
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
49
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
50
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
2 Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies. Completed NCT00370591 Phase 4 Salmeterol/fluticasone propionate and fluticasone propionate
3 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Recruiting NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
4 Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup Recruiting NCT03705273 Phase 4 Dexamethasone IV for PO;Dexamethasone crushed tablets
5 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
6 A Trial of Point of Care Information in Ambulatory Pediatrics Completed NCT00368823 Phase 3
7 A Study to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine in Children Completed NCT01218308 Phase 3
8 Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy Recruiting NCT03211871 Phase 3 Dexmedetomidine;Normal Saline Flush, 0.9% Injectable Solution_#1
9 Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART) Active, not recruiting NCT00920621 Phase 3
10 Management of Recurrent Croup Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
11 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
12 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
13 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
14 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety of MEDI-559 in Healthy 1 to <24 Month-Old Children Completed NCT00767416 Phase 1, Phase 2
15 Phase IIb Study Evaluating Immunogenic Chemotherapy Combined With Ipilimumab and Nivolumab in Breast Cancer Recruiting NCT03409198 Phase 2 Ipilimumab;Nivolumab;Pegylated liposomal doxorubicin;Cyclophosphamide
16 Aprepitant Triple Therapy Caused Chemotherapy Induced Nausea And Vomiting In Gastrointestinal Tumors Recruiting NCT03674294 Phase 2 Aprepitant;Palonosetron;Dexamethasone;Placebo Oral Tablet
17 Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable? Active, not recruiting NCT03204760 Phase 2 Dexamethasone 8Mg Solution for Injection;Prednisolone Oral, Per 5 Mg
18 Safety of and Immune Response to Recombinant Live-Attenuated Parainfluenza Type 1 Virus Vaccine Completed NCT00641017 Phase 1
19 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
20 A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers Recruiting NCT00186927 Phase 1
21 , "Mucosal Injury During Nasotracheal Intubation for Dental Procedures in Children-does the Tube Design Matter?" Unknown status NCT02517294 Not Applicable
22 Diagnosing Respiratory Disease in Children Using Cough Sounds 2 Completed NCT03392363
23 Diagnosing Respiratory Disease in Children Using Cough Sounds Completed NCT02973282
24 A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children Completed NCT00626808 No Intervention
25 Re-evaluation of Blind Intubation Through the Air-Q Intubating Laryngeal Airway Completed NCT03778762 Not Applicable
26 Supplement to Hospital to Home Outcomes Completed NCT03224130 Not Applicable
27 Sunface Mirroring RCT in Brazil Not yet recruiting NCT03178240 Not Applicable
28 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849 Not Applicable

Search NIH Clinical Center for Croup

Cochrane evidence based reviews: croup

Genetic Tests for Croup

Anatomical Context for Croup

MalaCards organs/tissues related to Croup:

41
Trachea, Bone, Lung, Liver, Kidney, Testes, T Cells

Publications for Croup

Articles related to Croup:

(show top 50) (show all 792)
# Title Authors Year
1
Croup: What You Should Know. ( 29763268 )
2018
2
Croup: Diagnosis and Management. ( 29763253 )
2018
3
Prenatal phthalate exposure was associated with croup in Swedish infants. ( 29385277 )
2018
4
Prognostic factors and importance of recognition of adult croup. ( 29310492 )
2018
5
Automatic Croup Diagnosis Using Cough Sound Recognition. ( 29993458 )
2018
6
Air pollution is associated with incidence of viral croup among children living in Kraków area, Poland. ( 30079902 )
2018
7
Glucocorticoids for croup in children. ( 30133690 )
2018
8
Safety and utility of direct laryngoscopy and bronchoscopy in patients hospitalized with croup. ( 30138522 )
2018
9
Association of childhood croup and increased incidence of airway hyperreactivity in adulthood. ( 30159343 )
2018
10
Not All Stridor Is Croup. ( 30256321 )
2018
11
High rates of subglottic stenosis seen in African-American children admitted with severe croup to hospitals in the United States between 2003 and 2013. ( 30261993 )
2018
12
Heliox for croup in children. ( 30371952 )
2018
13
Prehospital dexamethasone administration in children with croup: a medical record review. ( 30410413 )
2018
14
Do Glucocorticoids Improve Symptoms and Reduce Return Visits or Admission Rates Among Children With Croup? ( 30529111 )
2018
15
A Systematic Review and Comprehensive Critical Analysis Examining the Use of Prednisolone for the Treatment of Mild to Moderate Croup. ( 29290883 )
2017
16
A Narrowing Diagnosis: A Rare Cause of Adult Croup and Literature Review. ( 28163937 )
2017
17
Management of Croup in the Emergency Department: The Role of Multidose Nebulized Epinephrine. ( 28953096 )
2017
18
Stridor is not always croup: infantile haemangioma in the airway. ( 28899875 )
2017
19
Croup ( 28613724 )
2017
20
Are cytokines and cortisol important predictors for the severity of pediatric croup: A case control study. ( 29376573 )
2017
21
Effects of pre-education combined with a simulation for caring for children with croup on senior nursing students. ( 28436091 )
2017
22
Variation in Inpatient Croup Management and Outcomes. ( 28292873 )
2017
23
Westley score and clinical factors in predicting the outcome of croup in the pediatric emergency department. ( 28556543 )
2017
24
Mistaken Identity: Asthma and Croup in a Previously Healthy 9-Year-Old Male. ( 28777267 )
2017
25
Failure of Outpatient Management With Different Observation Times After Racemic Epinephrine for Croup. ( 29034735 )
2017
26
Calculated decisions: Westley croup score ( 29115814 )
2017
27
What is the effectiveness of systemic corticosteroids in children with croup? ( 28622285 )
2017
28
Association of croup with asthma in children: A cohort study. ( 28858086 )
2017
29
Acute management of croup in the emergency department. ( 29532807 )
2017
30
Cough sound analysis for diagnosing croup in pediatric patients using biologically inspired features. ( 29060916 )
2017
31
Comparison of the Effect of Cold Drink and Dexamethasone, and their Combined Effect on Children with Croup. ( 29100262 )
2017
32
Endogenous Glucocorticoid Response to Single-Dose Dexamethasone for Croup in Children: A Pharmacodynamic Study. ( 28398936 )
2017
33
Invasive Aspergillus Laryngotracheobronchitis in an Adult with Primary CNS Lymphoma. ( 28213800 )
2017
34
Steeple sign and acute laryngotracheobronchitis. ( 29025139 )
2017
35
Croup. ( 27637124 )
2016
36
Esophageal Foreign Body: A Case Report of a Refractory Croup in a 20-Month-Old Boy. ( 28008396 )
2016
37
Delivery of Epinephrine in the Vapor Phase for the Treatment of Croup. ( 26910479 )
2016
38
Bronchoscopy findings in recurrent croup: A systematic review and meta-analysis. ( 27729160 )
2016
39
Intensive care management of children intubated for croup: a retrospective analysis. ( 27029657 )
2016
40
The role of larygotracheal reconstruction in the management of recurrent croup in patients with subglottic stenosis. ( 26857320 )
2016
41
Recurrent croup and persistent laryngomalacia: Clinical resolution after supraglottoplasty. ( 27063760 )
2016
42
Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child. ( 26889375 )
2016
43
Telephone Out Patient Score: The Derivation and Validation of a Telephone Follow-up Assessment Tool for Use in Clinical Research in Children With Croup. ( 27139290 )
2016
44
Croup. ( 26776546 )
2016
45
Use of laboratory and administrative data to understand the potential impact of human parainfluenza virus 4 on cases of bronchiolitis, croup, and pneumonia in Alberta, Canada. ( 27514690 )
2016
46
Child homicide or natural death? A case report of unexpected death of unusual asymptomatic acute laryngotracheobronchitis. ( 26101441 )
2016
47
Inpatient Treatment after Multi-Dose Racemic Epinephrine for Croup in the Emergency Department. ( 26242923 )
2015
48
Objective endoscopic findings in patients with recurrent croup: 10-year retrospective analysis. ( 26574171 )
2015
49
Steeple sign: a case of croup. ( 25929218 )
2015
50
Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea. ( 26576182 )
2015

Variations for Croup

Expression for Croup

Search GEO for disease gene expression data for Croup.

Pathways for Croup

Pathways related to Croup according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 ATP6AP1 CD14

GO Terms for Croup

Molecular functions related to Croup according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rab GTPase binding GO:0017137 8.62 ATP6AP1 RIMS2

Sources for Croup

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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