MCID: CRS013
MIFTS: 27

Crustacean Allergy

Categories: Immune diseases

Aliases & Classifications for Crustacean Allergy

MalaCards integrated aliases for Crustacean Allergy:

Name: Crustacean Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060524

Summaries for Crustacean Allergy

Disease Ontology : 12 A shellfish allergy triggered by Crustacea.

MalaCards based summary : Crustacean Allergy is related to shrimp allergy and brown shrimp allergy. An important gene associated with Crustacean Allergy is TPM4 (Tropomyosin 4), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Dilated cardiomyopathy (DCM). The drugs Chitosan and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related phenotypes are Decreased cell migration and Synthetic lethal with imatinib mesylate

Related Diseases for Crustacean Allergy

Diseases related to Crustacean Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 shrimp allergy 28.1 TPSD1 TNFRSF10C TMEM189 SDF4 LGALS3 HLA-DQA2
2 brown shrimp allergy 11.4
3 crab allergy 11.4
4 indian prawn allergy 11.4
5 tiger prawn allergy 11.4
6 white shrimp allergy 11.4
7 childhood-onset nemaline myopathy 10.5 TPM3 TPM2
8 cap myopathy 10.5 TPM3 TPM2
9 congenital structural myopathy 10.4 TPM3 TPM2
10 fetal adenoma 10.3 LGALS3 ACTB
11 baylisascariasis 10.3 IL4 GAPDH
12 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 10.2 TPM3 TPM2
13 mesenchymal cell neoplasm 10.0 TPM4 TPM3
14 fish allergy 10.0 TMEM189 LGALS3

Graphical network of the top 20 diseases related to Crustacean Allergy:



Diseases related to Crustacean Allergy

Symptoms & Phenotypes for Crustacean Allergy

GenomeRNAi Phenotypes related to Crustacean Allergy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.26 ACTB MAPK14 TPM1 TPM4
2 Synthetic lethal with imatinib mesylate GR00181-A 8.8 GAPDH IL4 TPM1

Drugs & Therapeutics for Crustacean Allergy

Drugs for Crustacean Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chitosan Experimental 9012-76-4 71853
2 Coagulants
3 Lipid Regulating Agents
4 Hemostatics
5 Chelating Agents
6 Hypolipidemic Agents
7 Antimetabolites
8 Anticholesteremic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety of Chitosan as Wine Fining Agent in Shrimp Allergic Patients Unknown status NCT02151279
2 Crustacean Allergy and Sensitization to Dust Mites in Patients With Respiratory Allergy: Clinical Study and Analysis of Common and Peculiar Allergens Completed NCT01634737

Search NIH Clinical Center for Crustacean Allergy

Genetic Tests for Crustacean Allergy

Anatomical Context for Crustacean Allergy

MalaCards organs/tissues related to Crustacean Allergy:

41
T Cells

Publications for Crustacean Allergy

Articles related to Crustacean Allergy:

(show all 12)
# Title Authors PMID Year
1
Cross-allergenicity of crustacean and the edible insect Gryllus bimaculatus in patients with shrimp allergy. 38
30597474 2019
2
Edible insects: Cross-recognition of IgE from crustacean- and house dust mite allergic patients, and reduction of allergenicity by food processing. 38
30937131 2019
3
Potential efficacy of processing technologies for mitigating crustacean allergenicity. 38
29851498 2018
4
Effect of thermal processing on T cell reactivity of shellfish allergens - Discordance with IgE reactivity. 38
28273149 2017
5
Molecular cloning and functional expression of allergenic sarcoplasmic calcium-binding proteins from Penaeus shrimps. 38
23180551 2013
6
Purification, cloning, expression and immunological analysis of Scylla serrata arginine kinase, the crab allergen. 38
21432856 2011
7
Adult seafood allergy in the Texas Medical Center: A 13-year experience. 38
22852122 2011
8
Effects of different processing methods on digestibility of Scylla paramamosain allergen (tropomyosin). 38
21130825 2011
9
Shellfish allergy. 38
20412131 2010
10
Prevalence of seafood allergy in the United States determined by a random telephone survey. 38
15241360 2004
11
Assembly of the Heparin Removal Device for patients with suspected adverse reaction to protamine sulphate. 38
11001169 2000
12
Molecular identification of the lobster muscle protein tropomyosin as a seafood allergen. 38
9597774 1998

Variations for Crustacean Allergy

Expression for Crustacean Allergy

Search GEO for disease gene expression data for Crustacean Allergy.

Pathways for Crustacean Allergy

GO Terms for Crustacean Allergy

Cellular components related to Crustacean Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.85 TPM4 TPM3 TPM2 TPM1 GAPDH ACTB
2 actin cytoskeleton GO:0015629 9.56 TPM3 TPM2 TPM1 ACTB
3 stress fiber GO:0001725 9.33 TPM4 TPM3 TPM1
4 bleb GO:0032059 9.32 TPM1 SDF4
5 actin filament GO:0005884 9.26 TPM4 TPM3 TPM2 TPM1
6 muscle thin filament tropomyosin GO:0005862 8.92 TPM4 TPM3 TPM2 TPM1

Biological processes related to Crustacean Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.46 TPM4 TPM3 TPM2 TPM1
2 actin filament organization GO:0007015 9.26 TPM4 TPM3 TPM2 TPM1
3 muscle filament sliding GO:0030049 8.92 TPM4 TPM3 TPM2 TPM1

Molecular functions related to Crustacean Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.62 TPM4 TPM3 TPM2 TPM1
2 actin filament binding GO:0051015 9.46 TPM4 TPM3 TPM2 TPM1
3 protein phosphatase binding GO:0019903 9.43 TBK1 MAPK14 LGALS3
4 identical protein binding GO:0042802 9.17 TPM4 TPM2 TPM1 TBK1 SDF4 GAPDH
5 structural constituent of muscle GO:0008307 9.13 TPM4 TPM2 TPM1

Sources for Crustacean Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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