MCID: CRY004
MIFTS: 47

Cryoglobulinemia

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Cryoglobulinemia

MalaCards integrated aliases for Cryoglobulinemia:

Name: Cryoglobulinemia 12 73 54 44 15 17 70
Cryoimmunoglobulinaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2917
MeSH 44 D003449
NCIt 50 C26736
SNOMED-CT 67 30911005
ICD10 32 D89.1
UMLS 70 C0010403

Summaries for Cryoglobulinemia

Disease Ontology : 12 A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

MalaCards based summary : Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to cryoglobulinemia, familial mixed and hepatitis c virus. An important gene associated with Cryoglobulinemia is IFNA1 (Interferon Alpha 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Velpatasvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and skin, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Cryoglobulinemia is a medical condition in which the blood contains large amounts of pathological cold... more...

Related Diseases for Cryoglobulinemia

Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 714)
# Related Disease Score Top Affiliating Genes
1 cryoglobulinemia, familial mixed 32.4 TSLP IFNA2 IFNA1 CD5 CD40LG
2 hepatitis c virus 31.4 IFNL3 IFNG GPT CD81
3 membranoproliferative glomerulonephritis 31.2 TSLP IFNA1 CD79A
4 proliferative glomerulonephritis 31.0 IL6 IFNG CXCL10
5 purpura 30.9 TNFSF13B TNF IL6 IFNG CD79A APOH
6 polyneuropathy 30.8 TNF IL6 IFNA2 CD40LG
7 macroglobulinemia 30.8 TNFSF13B IL6 CD40LG CD27
8 vasculitis 30.7 TNFSF13B TNF IL6 IFNA2 CD79A CD40LG
9 hepatitis c 30.6 TNF IFNG IFNA2 IFNA1 GPT CXCL10
10 thyroiditis 30.5 TNF IL6 IFNG IFNA1 HLA-DRB1 CXCL10
11 monoclonal gammopathy of uncertain significance 30.4 TNF IL6 CD27
12 cryofibrinogenemia 30.4 CD79A CD40LG
13 q fever 30.4 TNF IL6 IFNG
14 exanthem 30.4 TNF IL6 IFNG IFNA1 GPT
15 brucellosis 30.4 TNF IL6 IFNG
16 lymphoplasmacytic lymphoma 30.4 CD79A CD5 CD40LG
17 lichen planus 30.3 TNF IL6 IFNG
18 myeloma, multiple 30.3 TNFSF13B TNF IL6 CD5 CD27
19 anemia, autoimmune hemolytic 30.3 TNFSF13B CD5 CD40LG
20 leishmaniasis 30.3 TNF IL6 IFNG HLA-DRB1
21 endocarditis 30.3 TNF IL6 IFNG APOH
22 hypersensitivity reaction type iii disease 30.2 TNF IL6 CD79A
23 hepatitis 30.2 TNF IFNG IFNA2 IFNA1 GPT CXCL10
24 erythema multiforme 30.2 TNF IL6 IFNG
25 erythema nodosum 30.2 TNF IL6 IFNG
26 leprosy 3 30.2 TNF IL6 IFNG HLA-DRB1 CXCL10
27 liver disease 30.2 TNF IL6 IFNA2 IFNA1 GPT
28 membranous nephropathy 30.1 TNF IL6 CD79A
29 agammaglobulinemia 30.1 TNF IL6 CR2 CD79A CD40LG
30 marginal zone b-cell lymphoma 30.1 CR2 CD79A CD5 CD40LG
31 guillain-barre syndrome 30.1 TNF HLA-DRB1 CD79A
32 infective endocarditis 30.1 TNF IL6 APOH
33 hepatitis a 30.0 TNF IFNG IFNA1 GPT
34 conjunctivitis 30.0 TNF IL6 IFNG
35 systemic scleroderma 30.0 TNF IL6 IFNG CD40LG
36 lymphoma, mucosa-associated lymphoid type 30.0 TNFSF13B CR2 CD79A CD5
37 sjogren syndrome 30.0 TNFSF13B CD79A CD40LG APOH
38 pyoderma 30.0 TNF IFNA2 APOH
39 uveitis 30.0 TNF IL6 IFNG IFNA2 CXCL10
40 pyoderma gangrenosum 30.0 TNF IFNA2 APOH
41 lymphoma, non-hodgkin, familial 30.0 TNFSF13B IL6 CR2 CD79A CD5 CD27
42 pneumocystosis 30.0 TNF IL6 CD40LG
43 leptospirosis 30.0 TNF IL6 IFNG
44 antiphospholipid syndrome 30.0 TNF CD79A CD40LG APOH
45 septic arthritis 29.9 TNF IFNG CXCL11
46 connective tissue disease 29.9 TNFSF13B TNF IL6 IFNG HLA-DRB1 CD40LG
47 retinal vein occlusion 29.9 TNF IL6 APOH
48 psoriatic arthritis 29.9 TNF IL6 IFNG HLA-DRB1 CXCL10
49 pericarditis 29.9 TNF IL6 IFNG
50 bronchiolitis obliterans 29.9 TNF IL6 IFNG

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to Cryoglobulinemia

Symptoms & Phenotypes for Cryoglobulinemia

MGI Mouse Phenotypes related to Cryoglobulinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.77 C1QBP CD27 CD40LG CD5 CD79A CD81
2 immune system MP:0005387 9.4 CD27 CD40LG CD5 CD79A CD81 CR2

Drugs & Therapeutics for Cryoglobulinemia

Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Velpatasvir Approved, Investigational Phase 2, Phase 3 1377049-84-7 67683363
2
Ledipasvir Approved Phase 2, Phase 3 1256388-51-8 67505836
3 Anti-Infective Agents Phase 2, Phase 3
4 Antiviral Agents Phase 2, Phase 3
5 Sofosbuvir-velpatasvir drug combination Phase 2, Phase 3
6 Ledipasvir, sofosbuvir drug combination Phase 2, Phase 3
7
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
8
Lactitol Approved, Investigational Phase 1, Phase 2 585-86-4 157355
9
belimumab Approved Phase 2 356547-88-1 5957 10451420
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11
rituximab Approved Phase 2 174722-31-7 10201696
12 Anti-Retroviral Agents Phase 1, Phase 2
13 Anti-HIV Agents Phase 1, Phase 2
14 Immunosuppressive Agents Phase 2
15 Tin Fluorides Phase 2
16 Immunologic Factors Phase 2
17 glucocorticoids Phase 2
18 Antineoplastic Agents, Immunological Phase 2
19 Hormone Antagonists Phase 2
20 Hormones Phase 2
21 Antirheumatic Agents Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23 Anti-Inflammatory Agents Phase 2
24
Sofosbuvir Approved 1190307-88-0 45375808
25
Ribavirin Approved 36791-04-5 37542
26 interferons
27 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia Completed NCT02825212 Phase 2, Phase 3 Harvoni;Epclusa
2 ANRS HC 21 VASCU IL-2, Evaluation of the Cellular Immune Response, Clinical Efficacy and Tolerance After IL-2 Therapy in HCV-related Vasculitis Patients, Resistant to Conventional Therapy. Completed NCT00574652 Phase 1, Phase 2 Proleukin
3 Multicenter Randomized Double-blind Study Comparing the Efficacy and Safety of Belimumab in the Treatment of Non-infectious Active Cryoglobulinemia Vasculitis Compared to Placebo. TRIBECA STUDY (Treatment nd BElimumab in Cryoglobulinemia Associated Vasculitis) Not yet recruiting NCT04629144 Phase 2 Belimumab;Placebo
4 Multicenter Randomized Double-blind Study Comparing the Efficacy and Safety of Rituximab in Combination With Corticosteroids to Corticosteroids Plus Placebo in the Treatment of Non-infectious Active Mixed Cryoglobulinemia Vasculitis Terminated NCT02556866 Phase 2 rituximab;Prednisone;Placebo
5 Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis Unknown status NCT02856243 new antiviral therapy
6 Different Histopathological Patterns in Patients With HCV Nephropathy Unknown status NCT03476031
7 Benefit of Direct-acting Antiviral Therapy in Hepatitis C Virus (HCV) Monoinfected and HIV-HCV Coinfected Patients With Mixed Cryoglobulinemia Completed NCT03342261 DAA treatment
8 The RITAI Cohort. An Observational Study on Serious Adverse Events Occuring After Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713 Rituximab (MABTHERA® or RITUXAN®).
9 Long-term Hepatic and Extra-hepatic Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Interferon-free Treatment (LONGHEAD Study) Recruiting NCT03042520
10 Registry for Adults With Plasma Cell Disorders (PCD's) Recruiting NCT03717844

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Interferon Alfa-2a
Interferon Alfa-2b
INTERFERON ALFA-3N,HUMAN LEUKOCYTE DERIVED
interferon alfacon-1
Interferon gamma-1b
Interferons
peginterferon alfa-2a
peginterferon alfa-2b
Recombinant interferon beta-1a
Recombinant interferon beta-1b

Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

Anatomical Context for Cryoglobulinemia

MalaCards organs/tissues related to Cryoglobulinemia:

40
Liver, Kidney, Skin, B Cells, Bone, Bone Marrow, Thyroid

Publications for Cryoglobulinemia

Articles related to Cryoglobulinemia:

(show top 50) (show all 3192)
# Title Authors PMID Year
1
[Auto-immune serological disorders in chronic viral C hepatitis: prevalence and clinical significance]. 54 61
19472775 2008
2
Hepatitis C-associated leukocytoclastic vasculitis with anticardiolipin antibodies causing penile necrosis and deep venous thrombosis in the absence of cryoglobulinemia. 61 54
18438797 2008
3
Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. 54 61
17322382 2007
4
Acute renal failure due to IgM-lambda glomerular thrombi and MPGN-like lesions in a patient with angioimmunoblastic T-Cell lymphoma. 54 61
16797380 2006
5
Prevalence of cryoglobulinemia in hepatitis C virus (HCV) positive patients with and without human immunodeficiency virus (HIV) coinfection. 54 61
15465414 2004
6
[Active arthritis due to cryoglobulinemia based on HCV infection in a patient with RA improvement of arthritis with IFN-alpha]. 61 54
15045816 2004
7
Prevalence of cryoglobulinemia and serological markers of autoimmunity in human immunodeficiency virus infected individuals: a cross-sectional study of 97 patients. 61 54
12966606 2003
8
The clinical and morphologic spectrum of renal cryoglobulinemia. 54 61
12352634 2002
9
Hepatitis C virus (HCV)-related cryoglobulinemia after liver transplantation for HCV cirrhosis. 61 54
11875606 2002
10
[Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. 54 61
11769562 2001
11
Hepatitis C virus infection with and without cryoglobulinemia as a case of Churg-Strauss syndrome. 61 54
10743831 2000
12
Cryoglobulinemia. 54 61
10626153 1999
13
A clinical and histologic study of 37 cases of immunoglobulin A-associated vasculitis. 61 54
10380044 1999
14
[Development of cyroglobulinemia and polyneuropathy in a chronic myeloid leukemia patient during interferon-alpha treatment]. 54 61
10355142 1999
15
Prevalence of cryoglobulinemia in chronic hepatitis C virus infection and response to treatment with interferon-alpha. 61 54
9451674 1997
16
[Acrosyndromes induced by bleomycin in HIV 1 related Kaposi's disease. 5 cases]. 61 54
9452752 1997
17
Interferon-alpha treatment of hepatitis C virus-associated mixed cryoglobulinemia. 61 54
9252075 1997
18
Hypertriglyceridemia during long-term interferon-alpha therapy in a series of hematologic patients. 54 61
9181461 1997
19
[Distal gangrene and cryoglobulinemia related to hepatitis C virus infection with presence of anticardiolipin antibodies]. 61 54
9161561 1997
20
Cryoglobulinemia in hepatitis C virus chronic active hepatitis: effects of interferon-alpha therapy. 61 54
8877728 1996
21
Serological markers of autoimmunity in renal transplant patients before and after alpha-interferon therapy for chronic hepatitis C. 61 54
8955758 1996
22
Long-term results regarding the use of recombinant interferon alpha-2b in the treatment of II type mixed essential cryoglobulinemia. 54 61
8832526 1995
23
Cryoglobulinemia in chronic hepatitis C virus infection: prevalence, clinical manifestations, response to interferon treatment and analysis of cryoprecipitates. 54 61
8600660 1995
24
A role for chronic hepatitis C virus infection in a patient with cutaneous vasculitis, cryoglobulinemia, and chronic liver disease. Effective therapy with interferon-alpha. 54 61
7781436 1995
25
Long-term results of therapy with interferon alpha for cryoglobulinemia associated with hepatitis C virus infection. 54 61
8187434 1994
26
Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma. 54 61
1300443 1992
27
[Cryoglobulinemia type II]. 61 54
2074925 1990
28
Impact of direct acting antivirals on hepatitis c virus-related cryoglobulinemic syndrome. 61
33793154 2021
29
Acute Peripheral and/or Cutaneous Ischemic Syndrome: What Rheumatologists Should Know. 61
33315786 2021
30
Genetic Association of Hepatitis C-Related Mixed Cryoglobulinemia: A 10-Year Prospective Study of Asians Treated with Antivirals. 61
33799903 2021
31
Obinutuzumab Rescue in Rituximab Resistant Mixed Cryoglobulinemia. 61
33733004 2021
32
Peripheral ulcerative keratitis as the primary clinical manifestation of type 2 cryoglobulinemia. 61
33745875 2021
33
Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic. 61
33237291 2021
34
The Successful Treatment of a Case of HCV-associated Cryoglobulinemic Glomerulonephritis with Rituximab, Direct-acting Antiviral Agents, Plasmapheresis and Long-term Steroid Despite Serologically Persistent Cryoglobulinemia. 61
32999232 2021
35
Hepatitis C-related membranoproliferative glomerulonephritis in the era of direct antiviral agents. 61
33605311 2021
36
Cryoglobulinemic glomerulonephritis with underlying occult HBV infection and Waldenström macroglobulinemia: A case report. 61
33607837 2021
37
Revealed the mystery of HBV related mixed cryoglobulinemia: potential biomarkers of disease progression. 61
33590837 2021
38
[Marked increase in high-sensitivity troponin I without evidence of acute coronary syndrome]. 61
33470231 2021
39
[Neurological complications of hepatitis C infections]. 61
33001263 2021
40
Structural Basis of a Conventional Recognition Mode of IGHV1-69 Rheumatoid Factors. 61
32185699 2021
41
Selective decrease in complement C2 hemolytic activity is a sensitive marker for cryoglobulinemia and active disease in hepatitis C patients. 61
33478873 2021
42
Severe cryoglobulinemia with cerebral infarction successfully treated with steroid and rituximab: A case report. 61
33489212 2021
43
Renal Involvement and HBV Infection Are Common in Chinese Patients With Cryoglobulinemia. 61
33717064 2021
44
Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study. 61
33248866 2021
45
Clinico-immunological outcomes of HCV-cured cryoglobulinemia: Lower relapse rate with interferon-based than interferon-free therapy. 61
33064930 2021
46
Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar). 61
32524338 2021
47
The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection. 61
33466993 2021
48
Subacute Onset Sensorimotor Axonal Neuropathy with Sicca Syndrome. 61
33603915 2020
49
Role of therapeutic plasma exchanges in systemic vasculitis. 61
33172734 2020
50
Ocular ischemic syndrome and facial palsy associated with cryoglobulinemia and primary Sjögren's syndrome. 61
33097292 2020

Variations for Cryoglobulinemia

Expression for Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for Cryoglobulinemia

Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 TNFSF13B TNF IL6 IFNL3 IFNG IFNA2
2
Show member pathways
13.6 TSLP TNFSF13B TNF IL6 IFNL3 IFNG
3
Show member pathways
13.29 TNFSF13B TNF IL6 CXCL11 CXCL10 CD40LG
4
Show member pathways
13.18 TNF IL6 IFNG IFNA2 IFNA1 CXCL11
5
Show member pathways
13.17 TNFSF13B TNF IL6 IFNL3 IFNG IFNA2
6 12.79 TNF IL6 IFNG IFNA2 IFNA1 HLA-DRB1
7
Show member pathways
12.72 TNF IL6 IFNG IFNA2 IFNA1 HLA-DRB1
8
Show member pathways
12.71 TNF IL6 IFNL3 IFNA2 IFNA1
9
Show member pathways
12.65 TNF IFNG CR2 CD40LG CD27
10
Show member pathways
12.62 TNF IFNG HLA-DRB1 CD79A CD40LG
11
Show member pathways
12.53 TNF IFNG IFNA2 IFNA1 CXCL10
12
Show member pathways
12.42 TSLP IL6 IFNL3 IFNG IFNA2 IFNA1
13
Show member pathways
12.32 TNF IL6 IFNG CXCL10
14
Show member pathways
12.32 TNF IL6 CXCL11 CXCL10
15
Show member pathways
12.25 TNF IFNG HLA-DRB1 CD40LG
16
Show member pathways
12.25 TNF IL6 IFNG IFNA2 IFNA1
17 12.22 TNF IL6 IFNA2 IFNA1
18
Show member pathways
12.19 TNF IFNG IFNA2 IFNA1
19
Show member pathways
12.19 TNF IL6 IFNG CXCL11 CXCL10
20 12.17 TNF IL6 IFNG IFNA2 IFNA1 HLA-DRB1
21 12.07 TNFSF13B TNF IFNG IFNA1 CXCL10 CD79A
22 12.03 TNFSF13B TNF IL6 IFNG CXCL10
23
Show member pathways
12.02 TNFSF13B TNF IL6 IFNG IFNA2 IFNA1
24 11.92 TNF IL6 HLA-DRB1 CR2 CD5
25 11.87 IL6 IFNG IFNA2 IFNA1
26 11.86 TNFSF13B TNF IL6 IFNG HLA-DRB1
27
Show member pathways
11.81 TNFSF13B TNF CD40LG CD27
28 11.77 TSLP TNF IFNG
29 11.76 TNF IL6 IFNG IFNA2
30
Show member pathways
11.75 TNF IL6 IFNG
31
Show member pathways
11.75 TNF IFNG CD40LG
32
Show member pathways
11.73 TNFSF13B TNF CD40LG
33 11.7 TNF IL6 IFNG IFNA2 CD79A CD5
34
Show member pathways
11.68 TNF IL6 IFNG CD40LG
35 11.59 TNFSF13B TNF IL6 CR2 CD40LG
36 11.55 TNF IL6 IFNG
37 11.54 IL6 IFNL3 IFNA2 IFNA1
38 11.52 TNF IL6 CXCL10
39 11.48 TNF IL6 IFNG
40 11.38 IFNG IFNA2 CXCL10
41 11.37 TNF IL6 IFNG
42 11.35 TNF IL6 IFNG CD81 CD40LG
43 11.32 TSLP TNF IL6 IFNG
44 11.22 TNF IL6 IFNG HLA-DRB1
45 11 TNFSF13B TNF IL6 CXCL11 CXCL10 CD40LG

GO Terms for Cryoglobulinemia

Cellular components related to Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TSLP TNFSF13B TNF IL6 IFNL3 IFNG
2 cell surface GO:0009986 9.73 TNF HLA-DRB1 CD40LG CD27 C1QBP APOH
3 external side of plasma membrane GO:0009897 9.7 TNF HLA-DRB1 CXCL10 CD79A CD5 CD40LG
4 extracellular space GO:0005615 9.5 TSLP TNFSF13B TNF IL6 IFNL3 IFNG

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.13 TNFSF13B HLA-DRB1 CR2 CD81 CD79A C1QBP
2 cell surface receptor signaling pathway GO:0007166 9.98 IFNG IFNA2 CXCL10 CD79A CD27
3 adaptive immune response GO:0002250 9.98 IFNG IFNA2 IFNA1 HLA-DRB1 CD81 CD79A
4 inflammatory response GO:0006954 9.97 TNF IL6 IFNA2 CXCL11 CXCL10 CD40LG
5 cytokine-mediated signaling pathway GO:0019221 9.93 TNF IL6 IFNL3 IFNA2 IFNA1 CXCL10
6 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL6 CXCL11 CXCL10
7 defense response GO:0006952 9.88 TNF IFNA2 IFNA1 CXCL11 CXCL10
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.86 TNFSF13B TNF CD40LG CD27
9 defense response to virus GO:0051607 9.85 IL6 IFNL3 IFNG IFNA2 IFNA1 CXCL10
10 regulation of insulin secretion GO:0050796 9.83 TNF IL6 IFNG
11 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.83 TSLP CXCL11 CXCL10
12 positive regulation of interleukin-6 production GO:0032755 9.83 TSLP TNF IL6 IFNG
13 positive regulation of T cell proliferation GO:0042102 9.81 TNFSF13B IL6 CD40LG
14 positive regulation of interleukin-1 beta production GO:0032731 9.8 TNF IL6 IFNG
15 T cell costimulation GO:0031295 9.79 TNFSF13B CD5 CD40LG
16 extrinsic apoptotic signaling pathway GO:0097191 9.77 TNF IFNG CD27
17 positive regulation of interleukin-10 production GO:0032733 9.75 TSLP IL6 CD40LG
18 B cell differentiation GO:0030183 9.72 IFNA2 IFNA1 CR2 CD79A CD40LG
19 positive regulation of chemokine production GO:0032722 9.71 TSLP TNF IL6 IFNG
20 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.69 IFNG IFNA2 IFNA1
21 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL6
22 T cell chemotaxis GO:0010818 9.67 CXCL11 CXCL10
23 negative regulation of amyloid-beta clearance GO:1900222 9.66 TNF IFNG
24 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
25 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 TSLP TNF IL6 IFNG IFNA2
26 regulation of immunoglobulin production GO:0002637 9.64 TNF CD40LG
27 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.63 IL6 CD81
28 vascular endothelial growth factor production GO:0010573 9.63 TNF IL6
29 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.62 HLA-DRB1 CD81
30 positive regulation of STAT cascade GO:1904894 9.6 TSLP IL6
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 TNF IFNG
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.55 TNF IFNG
33 humoral immune response GO:0006959 9.55 TNF IL6 IFNG IFNA2 IFNA1
34 positive regulation of nitrogen compound metabolic process GO:0051173 9.54 TNF IFNG
35 B cell proliferation GO:0042100 9.35 IFNA2 IFNA1 CR2 CD79A CD40LG
36 immune response GO:0006955 9.32 TNFSF13B TNF IL6 IFNG HLA-DRB1 CXCL11

Molecular functions related to Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TSLP TNFSF13B TNF IL6 IFNL3 IFNG
2 CXCR3 chemokine receptor binding GO:0048248 9.16 CXCL11 CXCL10
3 tumor necrosis factor receptor binding GO:0005164 9.13 TNFSF13B TNF CD40LG

Sources for Cryoglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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