MCID: CRY004
MIFTS: 48

Cryoglobulinemia

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Cryoglobulinemia

MalaCards integrated aliases for Cryoglobulinemia:

Name: Cryoglobulinemia 12 74 54 43 15 17 71
Cryoimmunoglobulinaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2917
MeSH 43 D003449
NCIt 49 C26736
SNOMED-CT 67 30911005
ICD10 32 D89.1
UMLS 71 C0010403

Summaries for Cryoglobulinemia

Disease Ontology : 12 A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

MalaCards based summary : Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to type ii mixed cryoglobulinemia and cryoglobulinemia, familial mixed. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs rituximab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include b cells, liver and kidney, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Cryoglobulinemia is a medical condition in which the blood contains large amounts of pathological cold... more...

Related Diseases for Cryoglobulinemia

Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 796)
# Related Disease Score Top Affiliating Genes
1 type ii mixed cryoglobulinemia 34.2 HLA-DRB1 CD5
2 cryoglobulinemia, familial mixed 34.0 TSLP IFNA2 IFNA1 CD5 CD40LG
3 waldenstroem's macroglobulinemia 32.2 TNFSF13B CD79A CD5 CD40LG CD27
4 membranoproliferative glomerulonephritis 31.4 TSLP IFNA1 CD79A
5 thyroiditis 31.2 TNF IL6 IFNA1
6 macroglobulinemia 31.0 TNFSF13B IL6 CD40LG CD27
7 hepatitis c 31.0 TNF IFNA2 IFNA1 GPT CXCL10 CD81
8 peripheral nervous system disease 30.9 TNF IL6 IL1B GPT CD40LG
9 purpura 30.9 TNFSF13B TNF IL6 CD79A CD40LG APOH
10 polyneuropathy 30.9 TNF IL6 IL1B IFNA2 CD40LG
11 hashimoto thyroiditis 30.8 TNF IL6 IL1B HLA-DRB1
12 vasculitis 30.7 TNFSF13B TNF IL6 IFNA2 CD79A CD40LG
13 cryofibrinogenemia 30.7 CD79A CD40LG
14 cytomegalovirus infection 30.7 TNF IL6 IL1B
15 amyloidosis 30.7 TNF IL6 IL1B CD40LG
16 poems syndrome 30.6 TNF IL6 IL1B
17 hepatitis 30.6 TNF IFNA2 IFNA1 GPT CXCL10 CD81
18 brucellosis 30.6 TNF IL6 CD40LG
19 endocarditis 30.5 TNF IL6 APOH
20 anemia, autoimmune hemolytic 30.5 TNFSF13B CD5 CD40LG
21 q fever 30.5 TNF IL6 IL1B CD40LG
22 neuritis 30.5 TNF IL6 IL1B CXCL10
23 monoclonal gammopathy of uncertain significance 30.5 TNF IL6 CD40LG CD27
24 visceral leishmaniasis 30.5 TNF IL1B HLA-DRB1
25 hepatitis b 30.4 TNF IL6 IFNA2 IFNA1 GPT
26 microscopic polyangiitis 30.4 TNF HLA-DRB1
27 churg-strauss syndrome 30.4 TNF IL1B HLA-DRB1 CD40LG
28 keratitis, hereditary 30.3 TNF IL6 IL1B
29 liver disease 30.3 TNF IL6 IL1B IFNA2 IFNA1 GPT
30 bacterial infectious disease 30.3 TNF IL6 IL1B CD40LG
31 hypersensitivity reaction type iii disease 30.3 TNF IL6 CD79A CD40LG
32 mesangial proliferative glomerulonephritis 30.3 IL6 CD79A CD40LG
33 exanthem 30.3 TNF IL6 IL1B IFNA1 GPT CD40LG
34 agammaglobulinemia 30.3 TNF IL6 CR2 CD79A CD40LG
35 iridocyclitis 30.3 TNF IL6 CD40LG
36 marginal zone b-cell lymphoma 30.3 CR2 CD79A CD5 CD40LG
37 macular retinal edema 30.3 TNF IL6 IL1B
38 palindromic rheumatism 30.3 TNF IL1B HLA-DRB1
39 hepatitis e 30.2 TNF GPT CD40LG
40 pneumocystosis 30.2 TNF IL6 CD40LG
41 hypersensitivity vasculitis 30.2 TNF IL6 CD40LG
42 candidiasis 30.2 TNF IL6 IL1B CD40LG
43 pure red-cell aplasia 30.2 IFNA1 HLA-DRB1 CD40LG
44 arthritis 30.2 TNFSF13B TNF IL6 IL1B HLA-DRB1
45 complex regional pain syndrome 30.2 TNF IL6 IL1B
46 systemic scleroderma 30.2 TNF IL6 IL1B CD40LG
47 infective endocarditis 30.2 TNF IL6 APOH
48 aphthous stomatitis 30.2 TNF IL6 IL1B
49 lymphoma 30.2 TNFSF13B IL6 CR2 CD5 CD40LG CD27
50 uveitis 30.2 TNF IL6 IL1B IFNA2 CXCL10

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to Cryoglobulinemia

Symptoms & Phenotypes for Cryoglobulinemia

MGI Mouse Phenotypes related to Cryoglobulinemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 C1QBP CD27 CD40LG CD5 CD79A CD81
2 immune system MP:0005387 9.44 CD27 CD40LG CD5 CD79A CD81 CR2

Drugs & Therapeutics for Cryoglobulinemia

Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 4 174722-31-7 10201696
2 Immunologic Factors Phase 4
3 Antirheumatic Agents Phase 4
4 Antineoplastic Agents, Immunological Phase 4
5
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Sofosbuvir Approved Phase 2, Phase 3 1190307-88-0 45375808
8
Ledipasvir Approved Phase 2, Phase 3 1256388-51-8 67505836
9 Dermatologic Agents Phase 3
10 Antifungal Agents Phase 3
11 Cyclosporins Phase 3
12 Calcineurin Inhibitors Phase 3
13 Antiviral Agents Phase 2, Phase 3
14 Anti-Infective Agents Phase 2, Phase 3
15 Ledipasvir, sofosbuvir drug combination Phase 2, Phase 3
16
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
17
Lactitol Approved, Investigational Phase 1, Phase 2 585-88-6, 585-86-4 493591
18
belimumab Approved Phase 2 356547-88-1 10451420 5957
19
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
20 Analgesics, Non-Narcotic Phase 1, Phase 2
21 Analgesics Phase 1, Phase 2
22 Interleukin-2 Phase 1, Phase 2
23 Anti-HIV Agents Phase 1, Phase 2
24 Anti-Retroviral Agents Phase 1, Phase 2
25 Immunosuppressive Agents Phase 2
26 Immunoglobulins Phase 2
27 Antibodies Phase 2
28 Pharmaceutical Solutions Phase 2
29 Antibodies, Monoclonal Phase 2
30 Hormones Phase 2
31 Antineoplastic Agents, Hormonal Phase 2
32 Hormone Antagonists Phase 2
33 glucocorticoids Phase 2
34 Anti-Inflammatory Agents Phase 2
35
Betamethasone Approved, Vet_approved 378-44-9 9782
36
Ribavirin Approved 36791-04-5 37542
37 Respiratory System Agents
38 Anti-Asthmatic Agents
39 Antimetabolites
40 interferons
41 Liver Extracts

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Influence of Plasma Exchange Therapy on the Pharmacokinetics of Rituximab in Patients Treated for Autoimmune Disorders. Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
2 Effect of Rituximab in Treatment of Primary Membranoproliferative Glomerulonephritis Unknown status NCT03180723 Phase 3 Rituximab;Cyclosporin
3 Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia Completed NCT02825212 Phase 2, Phase 3 Harvoni
4 Tolerance and Efficacy of Rituximab in Sjogren's Disease Completed NCT00740948 Phase 2, Phase 3 Rituximab (mabthera) Injection;Placebo: NaCl 0.9% or Glucose 5%
5 Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe Alopecia Areata Resistant to Conventional Systemic Treatment Unknown status NCT01840046 Phase 1, Phase 2 Interleukin-2
6 ANRS HC 21 VASCU IL-2, Evaluation of the Cellular Immune Response, Clinical Efficacy and Tolerance After IL-2 Therapy in HCV-related Vasculitis Patients, Resistant to Conventional Therapy. Completed NCT00574652 Phase 1, Phase 2 Proleukin
7 A Phase 2, Proof of Concept, 52-Week Open Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS Antibody, in Subjects With Primary Sjögren's Syndrome. Completed NCT01008982 Phase 2 LimphoStat-B
8 Rituximab (Anti-CD20) for the Treatment of Hepatitis C Associated Cryoglobulinemic Vasculitis Completed NCT00029107 Phase 2 Rituximab
9 Multicenter Randomized Double-blind Study Comparing the Efficacy and Safety of Rituximab in Combination With Corticosteroids to Corticosteroids Plus Placebo in the Treatment of Non-infectious Active Mixed Cryoglobulinemia Vasculitis Terminated NCT02556866 Phase 2 rituximab;Prednisone;Placebo
10 Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis Unknown status NCT02856243 new antiviral therapy
11 Different Histopathological Patterns in Patients With HCV Nephropathy Unknown status NCT03476031
12 Pattern of Skin Manifestations in Chronic Hepatitis c Virus Patients Before and After Direct Acting Anti Viral Drugs: Prospective Controlled Clinical Trial Unknown status NCT03170076
13 The ITP-RITUX Cohort: An Observational Study on Rituximab Off-label Use for Immune ThrombocytoPenia. Unknown status NCT01101295
14 Randomized Controlled Study of Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection Unknown status NCT02261662 Ribavirin;Betamethasone
15 Treatment of Hypertensive Leg Ulcer by Adipose Tissue Grafting Unknown status NCT01932021
16 An Investigation of Cognitive Functioning and Brain Metabolites in Patients With Non-Cirrhotic Hepatitis-C Both Pre- and Post-Treatment With Antiviral Medication Unknown status NCT00188201
17 Chronic Hepatitis C in Chronic Hemodialysis Recipients - An Observational Study Unknown status NCT03461250
18 Benefit of Direct-acting Antiviral Therapy in Hepatitis C Virus (HCV) Monoinfected and HIV-HCV Coinfected Patients With Mixed Cryoglobulinemia Completed NCT03342261 DAA treatment
19 The RITAI Cohort. An Observational Study on Serious Adverse Events Occuring After Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713 Rituximab (MABTHERA® or RITUXAN®).
20 Characterization of Clonal B Cell Populations in HCV Infection Completed NCT00435201
21 Effects of Brief and Prolonged Cold Application on Maximal Isometric Hand Grip Strength. Completed NCT02884193
22 Long-term Hepatic and Extra-hepatic Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Interferon-free Treatment (LONGHEAD Study) Recruiting NCT03042520
23 Registry for Adults With Plasma Cell Disorders (PCD's) Recruiting NCT03717844
24 Study to Determine the Hepatitis C Virus Infection Prevalence Among Patients Attended Primarily for Vasculitis and Other Potential Extrahepatic Manifestations Recruiting NCT03693586
25 Detection by Digital PCR and Next Generation Sequencing of Recurrent Mutations in Waldenström's Disease and Study of Their Distribution in the Different Biological Compartments Recruiting NCT03952052

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Interferon Alfa-2a
Interferon Alfa-2b
INTERFERON ALFA-3N,HUMAN LEUKOCYTE DERIVED
interferon alfacon-1
Interferon gamma-1b
Interferons
peginterferon alfa-2a
peginterferon alfa-2b
Recombinant interferon beta-1a
Recombinant interferon beta-1b

Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

Anatomical Context for Cryoglobulinemia

MalaCards organs/tissues related to Cryoglobulinemia:

40
B Cells, Liver, Kidney, Skin, Thyroid, T Cells, Bone

Publications for Cryoglobulinemia

Articles related to Cryoglobulinemia:

(show top 50) (show all 3140)
# Title Authors PMID Year
1
[Auto-immune serological disorders in chronic viral C hepatitis: prevalence and clinical significance]. 61 54
19472775 2008
2
Hepatitis C-associated leukocytoclastic vasculitis with anticardiolipin antibodies causing penile necrosis and deep venous thrombosis in the absence of cryoglobulinemia. 54 61
18438797 2008
3
Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. 61 54
17322382 2007
4
Acute renal failure due to IgM-lambda glomerular thrombi and MPGN-like lesions in a patient with angioimmunoblastic T-Cell lymphoma. 54 61
16797380 2006
5
Prevalence of cryoglobulinemia in hepatitis C virus (HCV) positive patients with and without human immunodeficiency virus (HIV) coinfection. 54 61
15465414 2004
6
[Active arthritis due to cryoglobulinemia based on HCV infection in a patient with RA improvement of arthritis with IFN-alpha]. 61 54
15045816 2004
7
Prevalence of cryoglobulinemia and serological markers of autoimmunity in human immunodeficiency virus infected individuals: a cross-sectional study of 97 patients. 54 61
12966606 2003
8
The clinical and morphologic spectrum of renal cryoglobulinemia. 61 54
12352634 2002
9
Hepatitis C virus (HCV)-related cryoglobulinemia after liver transplantation for HCV cirrhosis. 54 61
11875606 2002
10
[Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia]. 61 54
11769562 2001
11
Hepatitis C virus infection with and without cryoglobulinemia as a case of Churg-Strauss syndrome. 54 61
10743831 2000
12
Cryoglobulinemia. 61 54
10626153 1999
13
A clinical and histologic study of 37 cases of immunoglobulin A-associated vasculitis. 61 54
10380044 1999
14
[Development of cyroglobulinemia and polyneuropathy in a chronic myeloid leukemia patient during interferon-alpha treatment]. 61 54
10355142 1999
15
Prevalence of cryoglobulinemia in chronic hepatitis C virus infection and response to treatment with interferon-alpha. 54 61
9451674 1997
16
[Acrosyndromes induced by bleomycin in HIV 1 related Kaposi's disease. 5 cases]. 54 61
9452752 1997
17
Interferon-alpha treatment of hepatitis C virus-associated mixed cryoglobulinemia. 54 61
9252075 1997
18
Hypertriglyceridemia during long-term interferon-alpha therapy in a series of hematologic patients. 54 61
9181461 1997
19
[Distal gangrene and cryoglobulinemia related to hepatitis C virus infection with presence of anticardiolipin antibodies]. 54 61
9161561 1997
20
Cryoglobulinemia in hepatitis C virus chronic active hepatitis: effects of interferon-alpha therapy. 54 61
8877728 1996
21
Serological markers of autoimmunity in renal transplant patients before and after alpha-interferon therapy for chronic hepatitis C. 61 54
8955758 1996
22
Long-term results regarding the use of recombinant interferon alpha-2b in the treatment of II type mixed essential cryoglobulinemia. 61 54
8832526 1995
23
Cryoglobulinemia in chronic hepatitis C virus infection: prevalence, clinical manifestations, response to interferon treatment and analysis of cryoprecipitates. 61 54
8600660 1995
24
A role for chronic hepatitis C virus infection in a patient with cutaneous vasculitis, cryoglobulinemia, and chronic liver disease. Effective therapy with interferon-alpha. 61 54
7781436 1995
25
Long-term results of therapy with interferon alpha for cryoglobulinemia associated with hepatitis C virus infection. 61 54
8187434 1994
26
Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma. 54 61
1300443 1992
27
[Cryoglobulinemia type II]. 61 54
2074925 1990
28
Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar). 61
32524338 2020
29
A case of glomerulonephritis caused by brucellosis. 61
32508259 2020
30
Rituximab-associated Vasculitis Flare: Incidence, Predictors, and Outcome. 61
31371658 2020
31
Cryptococcosis in an HIV-negative, HCV positive, immunosenescent patient: a case report. 61
32510160 2020
32
Clinical characteristics and treatment outcome of type I cryoglobulinemia in Chinese patients: a single-center study of 45 patients. 61
32535708 2020
33
Confirmed Cryoglobulinemia and Hyperviscosity Syndrome Secondary to Multiple Myeloma-IgA Kappa from Routine Blood Test: a Case Report. 61
32538055 2020
34
Hepatitis C virus- related cryoglobulinemic vasculitis: A review of the role of the new direct antiviral agents (DAAs) therapy. 61
32540448 2020
35
Membranoproliferative Glomerulonephritis and Mixed Cryoglobulinemia as a Form of Presentation of Visceral Leishmaniasis. 61
32459796 2020
36
Cryoglobulinemia after the era of chronic hepatitis C infection. 61
32521323 2020
37
Coexistence of antiphospholipid syndrome and cryoglobulinemia in a patient with rheumatoid arthritis. 61
32388747 2020
38
Biomarkers of minimal residual disease in rituximab-treated patients with mixed cryoglobulinemia. 61
32333692 2020
39
Prevention of parvovirus B19-induced repetitive acute kidney failure by subcutaneous immunoglobulins. 61
31605404 2020
40
Remarkable pseudoleucocytosis induced by mild cryoglobulinemia. 61
32284440 2020
41
Structural Basis of a Conventional Recognition Mode of IGHV1-69 Rheumatoid Factors. 61
32185699 2020
42
Sentinel biomarkers in HCV positive patients with mixed cryoglobulinemia. 61
31669506 2020
43
Impact of mixed cryoglobulinemia on patients with spontaneous hepatitis C virus clearance: A 13-year prospective cohort study. 61
31782138 2020
44
Hepatitis A Virus Infection Associated with Cryoglobulinemic Vasculitis. 61
31937705 2020
45
Graves' disease: Epidemiology, genetic and environmental risk factors and viruses. 61
32107168 2020
46
Small Fiber Neuropathy: Clinicopathological Correlations. 61
32399084 2020
47
Extrahepatic manifestations of hepatitis E virus: An overview. 61
31601068 2020
48
The aggregation between AITD with rheumatologic, or dermatologic, autoimmune diseases. 61
31932147 2019
49
New insights in cryoglobulinemic vasculitis. 61
31383568 2019
50
Cryptococcosis in an HIV-negative, HCV positive, immunosenescent patient: a case report. 61
32334491 2019

Variations for Cryoglobulinemia

Expression for Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for Cryoglobulinemia

Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNFSF13B TNF IL6 IL1B IFNL3 IFNA2
2
Show member pathways
13.58 TSLP TNFSF13B TNF IL6 IL1B IFNL3
3
Show member pathways
13.41 TNFSF13B TNF IL6 IL1B CXCL11 CXCL10
4
Show member pathways
13.3 TNFSF13B TNF IL6 IL1B CXCL11 CXCL10
5
Show member pathways
13.17 TNFSF13B TNF IL6 IL1B IFNL3 IFNA2
6
Show member pathways
13.04 TNF IL6 IL1B IFNA2 IFNA1 CXCL11
7 12.8 TNF IL6 IL1B IFNA2 IFNA1 HLA-DRB1
8
Show member pathways
12.73 TNF IL6 IL1B IFNL3 IFNA2 IFNA1
9
Show member pathways
12.71 TNFSF13B TNF IL6 IL1B CD40LG
10
Show member pathways
12.68 TNF IL6 IL1B IFNA2 IFNA1 HLA-DRB1
11
Show member pathways
12.67 TNF IL1B CR2 CD40LG CD27
12
Show member pathways
12.59 TNFSF13B TNF IL1B CD40LG CD27
13
Show member pathways
12.56 IL6 IL1B IFNA2 IFNA1 CXCL10
14
Show member pathways
12.47 TSLP IL6 IFNL3 IFNA2 IFNA1
15
Show member pathways
12.33 TNF IL6 IL1B CXCL10
16
Show member pathways
12.33 TNF IL6 CXCL11 CXCL10
17
Show member pathways
12.28 TNF IL6 IL1B IFNA2 IFNA1
18
Show member pathways
12.26 TNF IL1B HLA-DRB1 CD40LG
19 12.25 TNF IL6 IL1B IFNA2 IFNA1
20
Show member pathways
12.21 TNF IL1B IFNA2 IFNA1
21
Show member pathways
12.19 TNF IL6 IL1B CXCL11 CXCL10
22 12.14 TNF IL6 IL1B IFNA2 IFNA1 HLA-DRB1
23 12.07 TNFSF13B TNF IL1B IFNA1 CXCL10 CD79A
24
Show member pathways
12.02 TNFSF13B TNF IL6 IL1B IFNA2 IFNA1
25 12 TNFSF13B TNF IL6 IL1B CXCL10
26 11.99 TNF IL6 IL1B CXCL10
27 11.97 TNF IL6 IFNA2 CD79A CD5
28 11.94 TNFSF13B TNF IL1B CD40LG
29 11.84 TNFSF13B TNF IL6 IL1B HLA-DRB1
30
Show member pathways
11.82 TNFSF13B TNF CD40LG CD27
31 11.78 TSLP TNF IL1B
32 11.77 TNF IL6 IL1B IFNA2
33 11.76 TNF IL6 IL1B
34
Show member pathways
11.74 TNFSF13B TNF CD40LG
35
Show member pathways
11.68 TNF IL6 IL1B CD40LG
36 11.67 TNF IL6 IL1B
37 11.63 TNF IL6 IL1B HLA-DRB1 CR2 CD5
38 11.62 TNF IL6 IL1B
39 11.55 TNF IL6 IL1B CXCL10
40 11.51 TNF IL6 IL1B
41 11.51 IL6 IFNL3 IFNA2 IFNA1
42 11.4 IL1B IFNA2 CXCL10
43 11.39 TNF IL6 IL1B
44 11.37 TNF IL6 IL1B
45 11.35 TNF IL6 IL1B CD81 CD40LG
46 11.31 TNF IL6 IL1B
47 11.3 TSLP TNF IL6 IL1B
48 11.2 TNF IL6 IL1B HLA-DRB1
49 11.01 TNFSF13B TNF IL6 IL1B CXCL11 CXCL10

GO Terms for Cryoglobulinemia

Cellular components related to Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TSLP TNFSF13B TNF IL6 IL1B IFNL3
2 cell surface GO:0009986 9.73 TNF HLA-DRB1 CD40LG CD27 C1QBP APOH
3 external side of plasma membrane GO:0009897 9.7 TNF HLA-DRB1 CXCL10 CD79A CD5 CD40LG
4 extracellular space GO:0005615 9.5 TSLP TNFSF13B TNF IL6 IL1B IFNL3

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.28 TSLP TNFSF13B IL6 IL1B IFNA1 HLA-DRB1
2 immune system process GO:0002376 10.13 TNFSF13B HLA-DRB1 CR2 CD81 CD79A C1QBP
3 adaptive immune response GO:0002250 10.03 IFNA2 IFNA1 HLA-DRB1 CD81 CD79A C1QBP
4 cell-cell signaling GO:0007267 9.97 IL1B IFNA2 CXCL11 CXCL10
5 defense response to virus GO:0051607 9.92 IL6 IFNL3 IFNA2 IFNA1 CXCL10
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF IL6 IL1B CD40LG
7 cellular response to lipopolysaccharide GO:0071222 9.89 TNF IL6 IL1B CXCL11 CXCL10
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.88 TNFSF13B TNF CD40LG CD27
9 inflammatory response GO:0006954 9.87 TNF IL6 IL1B IFNA2 CXCL11 CXCL10
10 positive regulation of JNK cascade GO:0046330 9.85 TNF IL1B CD27
11 defense response GO:0006952 9.85 TNF IFNA2 IFNA1 CXCL11 CXCL10
12 neutrophil chemotaxis GO:0030593 9.84 IL1B CXCL11 CXCL10
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.82 TNF IL1B CD27
14 T cell costimulation GO:0031295 9.81 TNFSF13B CD5 CD40LG
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 TSLP TNF IL6 IFNA2
16 positive regulation of T cell proliferation GO:0042102 9.78 TNFSF13B IL6 IL1B CD40LG
17 negative regulation of neurogenesis GO:0050768 9.74 TNF IL6 IL1B
18 humoral immune response GO:0006959 9.73 TNF IL6 IFNA2 IFNA1
19 positive regulation of chemokine production GO:0032722 9.72 TSLP TNF IL6
20 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6 IL1B
21 cytokine-mediated signaling pathway GO:0019221 9.7 TNF IL6 IL1B IFNL3 IFNA2 IFNA1
22 positive regulation of interleukin-6 production GO:0032755 9.67 TSLP TNF IL6 IL1B
23 negative regulation of lipid storage GO:0010888 9.66 TNF IL6
24 regulation of establishment of endothelial barrier GO:1903140 9.65 TNF IL1B
25 B cell differentiation GO:0030183 9.65 IFNA2 IFNA1 CR2 CD79A CD40LG
26 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.64 IL6 CD81
27 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.64 HLA-DRB1 CD81
28 positive regulation of STAT cascade GO:1904894 9.62 TSLP IL6
29 regulation of immunoglobulin secretion GO:0051023 9.62 TNF CD40LG
30 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
31 immunoglobulin secretion GO:0048305 9.6 TNFSF13B CD40LG
32 sequestering of triglyceride GO:0030730 9.59 TNF IL1B
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IL1B
34 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
35 B cell proliferation GO:0042100 9.35 IFNA2 IFNA1 CR2 CD79A CD40LG
36 immune response GO:0006955 9.32 TNFSF13B TNF IL6 IL1B HLA-DRB1 CXCL11

Molecular functions related to Cryoglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TSLP TNFSF13B TNF IL6 IL1B IFNL3
2 CXCR3 chemokine receptor binding GO:0048248 9.16 CXCL11 CXCL10
3 tumor necrosis factor receptor binding GO:0005164 9.13 TNFSF13B TNF CD40LG

Sources for Cryoglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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