MCID: CRY007
MIFTS: 54

Cryoglobulinemia, Familial Mixed

Categories: Bone diseases, Cardiovascular diseases, Genetic diseases, Immune diseases, Nephrological diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Cryoglobulinemia, Familial Mixed

MalaCards integrated aliases for Cryoglobulinemia, Familial Mixed:

Name: Cryoglobulinemia, Familial Mixed 58 74
Mixed Cryoglobulinemia 60 56 74
Essential Mixed Cryoglobulinemia 60 74
Cryoglobulinemic Vasculitis 60 74
Essential Cryoglobulinemia 60 74
Primary Cryoglobulinemia 60 74
Meltzer Syndrome 58 54
Familial Mixed Cryoglobulinemia 54
Mc 60

Characteristics:

Orphanet epidemiological data:

60
cryoglobulinemic vasculitis
Age of onset: All ages;

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
cryoglobulinemia, familial mixed:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Cryoglobulinemia, Familial Mixed

NIH Rare Diseases : 54 Familial mixed cryoglobulinemia is a rare condition that is characterized by the presence of abnormal proteins (called cryoglobulins) in the blood. These proteins clump together into a "gel-like" consistency at low temperatures, which can lead to inflammation, blocked blood vessels, and a variety of health problems. The associated signs and symptoms vary from person to person depending on which parts of the body or organ systems are affected; however, common features include purpura, joint pain, breathing problems, muscle pain, fatigue, glomerulonephritis, Raynaud's phenomenon, and skin abnormalities. The underlying genetic cause of familial mixed cryoglobulinemia is currently unknown. Although there are only a few reported families with this condition, it appears to be inherited in an autosomal dominant manner. Treatment is based on the signs and symptoms present in each person. In severe cases, medications that suppress the immune system may be necessary.

MalaCards based summary : Cryoglobulinemia, Familial Mixed, also known as mixed cryoglobulinemia, is related to waldenstrom macroglobulinemia and marginal zone b-cell lymphoma. An important gene associated with Cryoglobulinemia, Familial Mixed is TSLP (Thymic Stromal Lymphopoietin), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and B Cell Development Pathways. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related phenotypes are muscle weakness and fever

Description from OMIM: 123550

Related Diseases for Cryoglobulinemia, Familial Mixed

Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii Type Ii Mixed Cryoglobulinemia

Diseases related to Cryoglobulinemia, Familial Mixed via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 waldenstrom macroglobulinemia 29.9 CD40LG IGHM
2 marginal zone b-cell lymphoma 29.9 CD40LG CD5
3 cryoglobulinemia 29.7 CD40LG CD5 IFNA2 TSLP
4 viral hepatitis 29.6 IFNA1 IFNA2
5 leukemia, chronic lymphocytic 29.5 BCR CD40LG CD5 IGHM
6 hairy cell leukemia 29.4 CD5 IFNA1 IFNA2
7 autoimmune disease 29.2 CD40LG ENO1 IFNA1
8 type ii mixed cryoglobulinemia 12.4
9 glomerulopathy with fibronectin deposits 2 11.3
10 vasculitis 10.9
11 hepatitis 10.6
12 hepatitis c 10.5
13 hepatitis c virus 10.5
14 polyarteritis nodosa 10.3
15 liver disease 10.2
16 scleroderma, familial progressive 10.2
17 purpura 10.2
18 autoimmune lymphoproliferative syndrome, type v 10.1
19 thyroiditis 10.1
20 lymphomatous thyroiditis 10.1
21 agammaglobulinemia, x-linked 10.1 CD40LG IGHM
22 hepatitis b 10.1
23 systemic scleroderma 10.1
24 henoch-schoenlein purpura 10.1
25 leukemia, chronic lymphocytic 2 10.1
26 leukemia 10.1
27 lymphoma 10.1
28 lymphocytic leukemia 10.1
29 peripheral nervous system disease 10.1
30 neuropathy 10.1
31 leukemia, b-cell, chronic 10.1
32 anemia, autoimmune hemolytic 10.1 CD40LG CD5
33 membranoproliferative glomerulonephritis 10.1
34 ischemia 10.1
35 lymphomatoid granulomatosis 10.0 IFNA1 IFNA2
36 squamous papillomatosis 10.0 IFNA1 IFNA2
37 common cold 10.0 IFNA2 TSLP
38 herpangina 10.0 IFNA1 IFNA2
39 discoid lupus erythematosus 10.0 IFNA1 IFNA2
40 gastroenteritis 10.0 IFNA1 TSLP
41 lymphoma, hodgkin, classic 10.0
42 lymphoma, non-hodgkin, familial 10.0
43 noonan syndrome 3 10.0
44 lymphoproliferative syndrome 10.0
45 q fever 10.0
46 scleritis 10.0
47 proliferative glomerulonephritis 10.0
48 peritonitis 10.0
49 spondyloarthropathy 1 10.0
50 systemic lupus erythematosus 10.0

Graphical network of the top 20 diseases related to Cryoglobulinemia, Familial Mixed:



Diseases related to Cryoglobulinemia, Familial Mixed

Symptoms & Phenotypes for Cryoglobulinemia, Familial Mixed

Human phenotypes related to Cryoglobulinemia, Familial Mixed:

60 33 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 muscle weakness 60 33 hallmark (90%) Very frequent (99-80%) HP:0001324
2 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
3 skin ulcer 60 33 hallmark (90%) Very frequent (99-80%) HP:0200042
4 petechiae 60 33 hallmark (90%) Very frequent (99-80%) HP:0000967
5 vasculitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002633
6 mediastinal lymphadenopathy 60 33 hallmark (90%) Very frequent (99-80%) HP:0100721
7 cutis marmorata 60 33 hallmark (90%) Very frequent (99-80%) HP:0000965
8 cryoglobulinemia 60 33 hallmark (90%) Very frequent (99-80%) HP:0100778
9 circulating immune complexes 60 33 hallmark (90%) Very frequent (99-80%) HP:0012224
10 arthritis 60 33 frequent (33%) Frequent (79-30%) HP:0001369
11 splenomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0001744
12 hepatomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002240
13 renal insufficiency 60 33 frequent (33%) Frequent (79-30%) HP:0000083
14 proteinuria 60 33 frequent (33%) Frequent (79-30%) HP:0000093
15 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
16 abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002027
17 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
18 glomerulopathy 60 33 frequent (33%) Frequent (79-30%) HP:0100820
19 hematuria 60 33 frequent (33%) Frequent (79-30%) HP:0000790
20 gastrointestinal infarctions 60 33 frequent (33%) Frequent (79-30%) HP:0005244
21 gangrene 60 33 frequent (33%) Frequent (79-30%) HP:0100758
22 sensorimotor neuropathy 60 33 frequent (33%) Frequent (79-30%) HP:0007141
23 viral hepatitis 60 33 frequent (33%) Frequent (79-30%) HP:0006562
24 mononeuropathy 60 33 frequent (33%) Frequent (79-30%) HP:0009831
25 keratoconjunctivitis sicca 60 33 occasional (7.5%) Occasional (29-5%) HP:0001097
26 gastrointestinal hemorrhage 60 33 occasional (7.5%) Occasional (29-5%) HP:0002239
27 hypertension 33 HP:0000822
28 peripheral neuropathy 60 Frequent (79-30%)
29 purpura 60 Very frequent (99-80%)
30 elevated serum creatinine 33 HP:0003259
31 abnormality of blood and blood-forming tissues 33 HP:0001871
32 abnormality of the liver 60 Frequent (79-30%)
33 chronic kidney disease 33 HP:0012622
34 anasarca 33 HP:0012050

Symptoms via clinical synopsis from OMIM:

58
Endocrine:
hypertension

Misc:
anasarca

G U:
loss of renal function

Lab:
proteinuria
hematuria
elevated serum creatinine

Heme:
cryoglobulinemia

Clinical features from OMIM:

123550

GenomeRNAi Phenotypes related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

27 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 BCR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 IFNA1 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 BCR IFNA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.78 BCR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.78 BCR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.78 IFNA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.78 BCR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.78 BCR IFNA1 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.78 IFNA1 IFNA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.78 IFNA1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 BCR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 IFNA1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.78 BCR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.78 IFNA2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 BCR IFNA2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.78 IFNA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 IFNA1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.78 IFNA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.78 IFNA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.78 IFNA1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.78 BCR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 BCR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.78 IFNA1

Drugs & Therapeutics for Cryoglobulinemia, Familial Mixed

Drugs for Cryoglobulinemia, Familial Mixed (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sofosbuvir Approved Phase 2, Phase 3 1190307-88-0 45375808
2
Ledipasvir Approved Phase 2, Phase 3 1256388-51-8 67505836
3 Antiviral Agents Phase 2, Phase 3,Phase 1
4 Anti-Infective Agents Phase 2, Phase 3,Phase 1
5 Ledipasvir, sofosbuvir drug combination Phase 2, Phase 3
6
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
7
rituximab Approved Phase 2 174722-31-7 10201696
8
Aldesleukin Approved Phase 1, Phase 2 110942-02-4, 85898-30-2
9
Lactitol Investigational Phase 1, Phase 2 585-88-6, 585-86-4 493591
10 Antineoplastic Agents, Hormonal Phase 2
11 Hormones Phase 2
12 Hormone Antagonists Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
14 Immunologic Factors Phase 2
15 glucocorticoids Phase 2
16 Antirheumatic Agents Phase 2
17 Anti-Inflammatory Agents Phase 2
18 Antineoplastic Agents, Immunological Phase 2
19 Anti-Retroviral Agents Phase 1, Phase 2
20 Anti-HIV Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia Recruiting NCT02825212 Phase 2, Phase 3 Harvoni
2 Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia Vasculitis Terminated NCT02556866 Phase 2 rituximab;Prednisone;Placebo
3 Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis Patients Completed NCT00574652 Phase 1, Phase 2 Proleukin
4 Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis Unknown status NCT02856243 new antiviral therapy
5 Benefit of DAA Therapy in HCV Monoinfected and HIV-HCV Coinfected Patients With Mixed Cryoglobulinemia Completed NCT03342261 DAA treatment
6 Characterization of Clonal B Cell Populations in HCV Infection Completed NCT00435201
7 Study to Determine the Hepatitis C Virus Infection Prevalence Among Patients Attended Primarily for Vasculitis Recruiting NCT03693586

Search NIH Clinical Center for Cryoglobulinemia, Familial Mixed

Genetic Tests for Cryoglobulinemia, Familial Mixed

Anatomical Context for Cryoglobulinemia, Familial Mixed

MalaCards organs/tissues related to Cryoglobulinemia, Familial Mixed:

42
B Cells, Skin, Liver, Thyroid, T Cells, Bone, Kidney

Publications for Cryoglobulinemia, Familial Mixed

Articles related to Cryoglobulinemia, Familial Mixed:

(show top 50) (show all 546)
# Title Authors Year
1
Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases. ( 29751499 )
2018
2
Retreatment of symptomatic hepatitis C virus genotype 3 associated mixed cryoglobulinemia with sofosbuvir and ribavirin: a case report. ( 29904727 )
2018
3
The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia. ( 29910796 )
2018
4
HCV-negative mixed cryoglobulinemia and kidney involvement: in-depth review on physiopathological and histological bases. ( 29956004 )
2018
5
Persistent mixed cryoglobulinemia after successful antiviral treatment of chronic hepatitis C virus infection: What's the next? ( 29966445 )
2018
6
Sofosbuvir-daclatasvir improves hepatitis C virus-induced mixed cryoglobulinemia: Upper Egypt experience. ( 29983581 )
2018
7
Hepatitis C mixed cryoglobulinemia with undetectable viral load: A case series. ( 30128338 )
2018
8
Interleukin-17A and B-cell activating factor in chronic hepatitis C patients with or without asymptomatic mixed cryoglobulinemia: effects of antiviral treatment and correlations with vitamin D. ( 30386121 )
2018
9
HCV-associated mixed cryoglobulinemia and b-cell non-Hodgkin's lymphoma - pathogenetically related problems. ( 30701914 )
2018
10
Different biochemical patterns in type II and type III mixed cryoglobulinemia in HCV positive patients. ( 29709461 )
2018
11
Interstitial granulomatous dermatitis in a patient with chronic hepatitis C and mixed cryoglobulinemia. ( 29469770 )
2018
12
Role of ribavirin in the treatment of hepatitis C virus-associated mixed cryoglobulinemia with interferon-free regimens. ( 29318374 )
2018
13
Decline of cellular activation in non-B cells after rituximab treatment in hepatitis C-associated mixed cryoglobulinemia vasculitis. ( 27666584 )
2017
14
Micro and nanoparticles as possible pathogenetic co-factors in mixed cryoglobulinemia. ( 27694373 )
2017
15
Successful ledipasvir + sofosbuvir treatment of active synovitis in a rheumatoid arthritis patient with hepatitis C virus-related mixed cryoglobulinemia. ( 27848256 )
2017
16
Efficacy and safety of long-term treatment with low-dose rituximab for relapsing mixed cryoglobulinemia vasculitis. ( 28111716 )
2017
17
Efficacy and Safety of Direct Acting Antivirals for the Treatment of Mixed Cryoglobulinemia. ( 28291241 )
2017
18
Recurrent Mixed Cryoglobulinemia Despite Sustained Virologic Response to Treatment: A Case Report. ( 28343737 )
2017
19
Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia. ( 28453396 )
2017
20
Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study. ( 26853322 )
2017
21
Treatment of HCV-Related Mixed Cryoglobulinemia. ( 26302805 )
2017
22
Direct-Acting Antivirals and Mixed Cryoglobulinemia Vasculitis: Long-Term Outcome of Patients Achieving HCV Eradication. ( 29109502 )
2017
23
MPGN and mixed cryoglobulinemia in a patient with hepatitis C - new treatment implications and renal outcomes. ( 29098140 )
2017
24
Systematic review of mixed cryoglobulinemia associated with hepatitis E virus infection: association or causation? ( 28852522 )
2017
25
Lymphoproliferative disease with mixed cryoglobulinemia and hyperviscosity syndrome in an HIV-infected patient: HCV is the only culprit. ( 28825444 )
2017
26
Thyroid Involvement in Hepatitis C Virus-Infected Patients with/without Mixed Cryoglobulinemia. ( 28736547 )
2017
27
Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases. ( 28661098 )
2017
28
Reversion of anergy signatures in clonal CD21low B cells of mixed cryoglobulinemia after clearance of HCV viremia. ( 28507081 )
2017
29
Mixed cryoglobulinemia: a diagnostic and therapeutic challenge. ( 28490478 )
2017
30
Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report. ( 26785421 )
2016
31
Treatment of hepatitis C virus-associated mixed cryoglobulinemia with direct-acting antiviral agents. ( 26474537 )
2016
32
Prospective study of guideline-tailored therapy with direct-acting antivirals for hepatitis C virus-associated mixed cryoglobulinemia. ( 27483451 )
2016
33
Hepatic and Mesenteric Vasculitis as Presenting Manifestation of Mixed Cryoglobulinemia Related to Chronic Hepatitis C Virus Infection in a Female Patient. ( 27219310 )
2016
34
Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study. ( 27161362 )
2016
35
Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia. ( 27139837 )
2016
36
Annular leukocytoclastic vasculitis associated with essential mixed cryoglobulinemia. ( 27098553 )
2016
37
Mixed cryoglobulinemia-associated Sjögren's syndrome leading to spontaneous rupture of the kidney: a case report. ( 27042145 )
2016
38
Incidence of thyroid disorders in mixed cryoglobulinemia: Results from a longitudinal follow-up. ( 26970485 )
2016
39
A Rare Cause of Unilateral Central Retinal Vein Occlusion in a Young Patient: Type III Mixed Cryoglobulinemia. ( 27418988 )
2016
40
Lymphoproliferative disease-related mixed cryoglobulinemia treated with rituximab and prednisolone. ( 28509274 )
2015
41
Recurrent Mixed Cryoglobulinemia (MCS): A Case Report and Literature Review. ( 26422544 )
2015
42
Pulmonary Extranodal Marginal Zone Lymphoma with Macroglobulinemia and Mixed Cryoglobulinemia Developed in a Patient with Chronic Hepatitis C. ( 26278303 )
2015
43
Early onset mixed cryoglobulinemia in hepatitis C. ( 26275272 )
2015
44
Abnormal CD4 + T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection. ( 26129991 )
2015
45
Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and response to PEG-IFN and ribavirin treatment. ( 26060059 )
2015
46
Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review. ( 26031898 )
2015
47
Combined treatment with antiviral therapy and rituximab in patients with mixed cryoglobulinemia: review of the literature and report of a case using direct antiviral agents-based antihepatitis C virus therapy. ( 25815218 )
2015
48
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. ( 25800158 )
2015
49
Persistence of mixed cryoglobulinemia despite cure of hepatitis C with new oral antiviral therapy including direct-acting antiviral sofosbuvir: A case series. ( 25746436 )
2015
50
The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation. ( 25452118 )
2015

Variations for Cryoglobulinemia, Familial Mixed

Expression for Cryoglobulinemia, Familial Mixed

Search GEO for disease gene expression data for Cryoglobulinemia, Familial Mixed.

Pathways for Cryoglobulinemia, Familial Mixed

Pathways related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.5 IFNA1 IFNA2 TSLP
2 10.88 CD40LG CD5
3 10.26 IFNA1 IFNA2

GO Terms for Cryoglobulinemia, Familial Mixed

Cellular components related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 CD40LG IFNA1 IFNA2 IGHM TSLP
2 external side of plasma membrane GO:0009897 9.13 CD40LG CD5 IGHM
3 extracellular space GO:0005615 9.1 CD40LG ENO1 IFNA1 IFNA2 IGHM TSLP

Biological processes related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.63 IFNA1 IFNA2 IGHM
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IFNA2 TSLP
3 type I interferon signaling pathway GO:0060337 9.51 IFNA1 IFNA2
4 humoral immune response GO:0006959 9.49 IFNA1 IFNA2
5 T cell costimulation GO:0031295 9.48 CD40LG CD5
6 regulation of signaling receptor activity GO:0010469 9.46 CD40LG IFNA1 IFNA2 TSLP
7 response to exogenous dsRNA GO:0043330 9.43 IFNA1 IFNA2
8 positive regulation of interleukin-10 production GO:0032733 9.4 CD40LG TSLP
9 T cell activation involved in immune response GO:0002286 9.37 IFNA1 IFNA2
10 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.32 IFNA1 IFNA2
11 natural killer cell activation involved in immune response GO:0002323 9.26 IFNA1 IFNA2
12 B cell differentiation GO:0030183 9.13 CD40LG IFNA1 IFNA2
13 B cell proliferation GO:0042100 8.8 CD40LG IFNA1 IFNA2

Molecular functions related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IFNA1 IFNA2
2 type I interferon receptor binding GO:0005132 8.96 IFNA1 IFNA2
3 cytokine activity GO:0005125 8.92 CD40LG IFNA1 IFNA2 TSLP

Sources for Cryoglobulinemia, Familial Mixed

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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