MC
MCID: CRY007
MIFTS: 54

Cryoglobulinemia, Familial Mixed (MC)

Categories: Rare diseases, Immune diseases, Neuronal diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Genetic diseases

Aliases & Classifications for Cryoglobulinemia, Familial Mixed

MalaCards integrated aliases for Cryoglobulinemia, Familial Mixed:

Name: Cryoglobulinemia, Familial Mixed 57 73
Mixed Cryoglobulinemia 59 55 73
Essential Mixed Cryoglobulinemia 59 73
Cryoglobulinemic Vasculitis 59 73
Essential Cryoglobulinemia 59 73
Primary Cryoglobulinemia 59 73
Meltzer Syndrome 57 53
Familial Mixed Cryoglobulinemia 53
Mc 59

Characteristics:

Orphanet epidemiological data:

59
cryoglobulinemic vasculitis
Age of onset: All ages;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
cryoglobulinemia, familial mixed:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Cryoglobulinemia, Familial Mixed

NIH Rare Diseases : 53 Familial mixed cryoglobulinemia is a rare condition that is characterized by the presence of abnormal proteins (called cryoglobulins) in the blood. These proteins clump together into a "gel-like" consistency at low temperatures, which can lead to inflammation, blocked blood vessels, and a variety of health problems. The associated signs and symptoms vary from person to person depending on which parts of the body or organ systems are affected; however, common features include purpura, joint pain, breathing problems, muscle pain, fatigue, glomerulonephritis, Raynaud's phenomenon, and skin abnormalities. The underlying genetic cause of familial mixed cryoglobulinemia is currently unknown. Although there are only a few reported families with this condition, it appears to be inherited in an autosomal dominant manner. Treatment is based on the signs and symptoms present in each person. In severe cases, medications that suppress the immune system may be necessary.

MalaCards based summary : Cryoglobulinemia, Familial Mixed, also known as mixed cryoglobulinemia, is related to cryoglobulinemia and type ii mixed cryoglobulinemia. An important gene associated with Cryoglobulinemia, Familial Mixed is TSLP (Thymic Stromal Lymphopoietin), and among its related pathways/superpathways are Regulation of IFNA signaling and B Cell Development Pathways. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related phenotypes are muscle weakness and arthritis

Description from OMIM: 123550

Related Diseases for Cryoglobulinemia, Familial Mixed

Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii Type Ii Mixed Cryoglobulinemia

Diseases related to Cryoglobulinemia, Familial Mixed via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 cryoglobulinemia 28.8 CD40LG CD5 IFNA2 TSLP
2 type ii mixed cryoglobulinemia 12.2
3 mixed cryoglobulinemia type iii 12.2
4 glomerulopathy with fibronectin deposits 2 11.1
5 vasculitis 10.6
6 waldenstrom macroglobulinemia 10.4 CD40LG IGHM
7 lymphoplasmacytic lymphoma 10.4 CD40LG CD5
8 plasma protein metabolism disease 10.3 CD40LG CD5
9 fasciolopsiasis 10.3 CD40LG IFNA1
10 anemia, autoimmune hemolytic 10.3 CD40LG CD5
11 kyasanur forest disease 10.3 CD40LG IFNA1
12 spinocerebellar ataxia, autosomal recessive 10 10.3 CD40LG IFNA2
13 autoimmune disease of blood 10.3 CD40LG CD5
14 upper respiratory tract disease 10.3 CD40LG TSLP
15 phlebotomus fever 10.3 CD40LG IFNA2
16 hepatitis d 10.3 CD40LG IFNA2
17 hepatitis 10.3
18 hepatitis c 10.3
19 lung lymphoma 10.3 CD40LG CD5
20 marginal zone b-cell lymphoma 10.2 CD40LG CD5
21 hepatitis c virus 10.2
22 lymphomatoid granulomatosis 10.2 IFNA1 IFNA2
23 squamous papillomatosis 10.2 IFNA1 IFNA2
24 common cold 10.2 IFNA2 TSLP
25 granulomatous hepatitis 10.2 CD40LG IFNA2
26 respiratory system disease 10.2 CD40LG TSLP
27 discoid lupus erythematosus 10.1 IFNA1 IFNA2
28 agammaglobulinemia, x-linked 10.1 BCR IGHM
29 hepatitis a 10.1 CD40LG IFNA2
30 chronic neutrophilic leukemia 10.1 IFNA1 IFNA2
31 leukocyte disease 10.1 CD40LG IFNA1
32 scleroderma, familial progressive 10.1
33 polyarteritis nodosa, childhood-onset 10.1
34 polyarteritis nodosa 10.1
35 human immunodeficiency virus infectious disease 10.0 CD40LG IFNA1
36 severe acute respiratory syndrome 10.0 CD40LG IFNA1
37 hepatitis b 10.0
38 purpura 10.0
39 b-cell expansion with nfkb and t-cell anergy 10.0 BCR CD5
40 giardiasis 9.9 CD40LG ENO1
41 rheumatic disease 9.8 CD40LG IFNA1
42 systemic lupus erythematosus 9.8
43 myeloma, multiple 9.8
44 membranous nephropathy 9.8
45 pulmonary hypertension 9.8
46 glomerulonephritis 9.8
47 crest syndrome 9.8
48 epidural abscess 9.8
49 mononeuropathy 9.8
50 cholecystitis 9.8

Graphical network of the top 20 diseases related to Cryoglobulinemia, Familial Mixed:



Diseases related to Cryoglobulinemia, Familial Mixed

Symptoms & Phenotypes for Cryoglobulinemia, Familial Mixed

Symptoms via clinical synopsis from OMIM:

57
Endocrine:
hypertension

Heme:
cryoglobulinemia

GU:
loss of renal function

Lab:
proteinuria
hematuria
elevated serum creatinine

Misc:
anasarca


Clinical features from OMIM:

123550

Human phenotypes related to Cryoglobulinemia, Familial Mixed:

59 32 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 muscle weakness 59 32 hallmark (90%) Very frequent (99-80%) HP:0001324
2 arthritis 59 32 frequent (33%) Frequent (79-30%) HP:0001369
3 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
4 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
5 renal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0000083
6 proteinuria 59 32 frequent (33%) Frequent (79-30%) HP:0000093
7 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
8 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
9 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
10 skin ulcer 59 32 hallmark (90%) Very frequent (99-80%) HP:0200042
11 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
12 glomerulopathy 59 32 frequent (33%) Frequent (79-30%) HP:0100820
13 keratoconjunctivitis sicca 59 32 occasional (7.5%) Occasional (29-5%) HP:0001097
14 hematuria 59 32 frequent (33%) Frequent (79-30%) HP:0000790
15 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
16 petechiae 59 32 hallmark (90%) Very frequent (99-80%) HP:0000967
17 vasculitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002633
18 mediastinal lymphadenopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100721
19 gastrointestinal infarctions 59 32 frequent (33%) Frequent (79-30%) HP:0005244
20 sensorimotor neuropathy 59 32 frequent (33%) Frequent (79-30%) HP:0007141
21 gangrene 59 32 frequent (33%) Frequent (79-30%) HP:0100758
22 cutis marmorata 59 32 hallmark (90%) Very frequent (99-80%) HP:0000965
23 cryoglobulinemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100778
24 circulating immune complexes 59 32 hallmark (90%) Very frequent (99-80%) HP:0012224
25 viral hepatitis 59 32 frequent (33%) Frequent (79-30%) HP:0006562
26 mononeuropathy 59 32 frequent (33%) Frequent (79-30%) HP:0009831
27 hypertension 32 HP:0000822
28 peripheral neuropathy 59 Frequent (79-30%)
29 purpura 59 Very frequent (99-80%)
30 elevated serum creatinine 32 HP:0003259
31 abnormality of blood and blood-forming tissues 32 HP:0001871
32 abnormality of the liver 59 Frequent (79-30%)
33 chronic kidney disease 32 HP:0012622
34 anasarca 32 HP:0012050

GenomeRNAi Phenotypes related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 BCR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 IFNA2 IFNA1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 BCR IFNA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.78 BCR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.78 BCR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.78 IFNA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.78 BCR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.78 BCR IFNA1 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.78 IFNA1 IFNA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.78 IFNA1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 BCR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 IFNA1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.78 BCR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.78 IFNA2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 IFNA2 BCR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.78 IFNA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 IFNA1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.78 IFNA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.78 IFNA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.78 IFNA1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.78 BCR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 BCR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.78 IFNA1

Drugs & Therapeutics for Cryoglobulinemia, Familial Mixed

Drugs for Cryoglobulinemia, Familial Mixed (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sofosbuvir Approved Phase 2, Phase 3 1190307-88-0 45375808
2
Ledipasvir Approved Phase 2, Phase 3 1256388-51-8 67505836
3 Anti-Infective Agents Phase 2, Phase 3,Phase 1
4 Antiviral Agents Phase 2, Phase 3,Phase 1
5 Ledipasvir, sofosbuvir drug combination Phase 2, Phase 3
6
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
7
rituximab Approved Phase 2 174722-31-7 10201696
8
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
9
Lactitol Investigational Phase 1, Phase 2 585-86-4 3871
10 Anti-HIV Agents Phase 1, Phase 2
11 Anti-Retroviral Agents Phase 1, Phase 2
12 glucocorticoids Phase 2
13 Hormone Antagonists Phase 2
14 Hormones Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
16 Anti-Inflammatory Agents Phase 2
17 Antirheumatic Agents Phase 2
18 Antineoplastic Agents, Hormonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia Recruiting NCT02825212 Phase 2, Phase 3 Harvoni
2 Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis Patients Completed NCT00574652 Phase 1, Phase 2 Proleukin
3 Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia Vasculitis Active, not recruiting NCT02556866 Phase 2 rituximab;Prednisone;Placebo
4 Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis Unknown status NCT02856243 new antiviral therapy
5 Benefit of DAA Therapy in HCV Monoinfected and HIV-HCV Coinfected Patients With Mixed Cryoglobulinemia Completed NCT03342261 DAA treatment
6 Characterization of Clonal B Cell Populations in HCV Infection Completed NCT00435201

Search NIH Clinical Center for Cryoglobulinemia, Familial Mixed

Genetic Tests for Cryoglobulinemia, Familial Mixed

Anatomical Context for Cryoglobulinemia, Familial Mixed

MalaCards organs/tissues related to Cryoglobulinemia, Familial Mixed:

41
B Cells, Skin, Liver, Kidney, Bone, Thyroid, Bone Marrow

Publications for Cryoglobulinemia, Familial Mixed

Articles related to Cryoglobulinemia, Familial Mixed:

(show top 50) (show all 531)
# Title Authors Year
1
HCV-negative mixed cryoglobulinemia and kidney involvement: in-depth review on physiopathological and histological bases. ( 29956004 )
2018
2
Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases. ( 29751499 )
2018
3
Benefit of direct-acting antiviral therapy for hepatitis C virus (HCV) in monoinfected and HIV-HCV coinfected patients with mixed cryoglobulinemia. ( 29870852 )
2018
4
Interstitial granulomatous dermatitis in a patient with chronic hepatitis C and mixed cryoglobulinemia. ( 29469770 )
2018
5
Different biochemical patterns in type II and type III mixed cryoglobulinemia in HCV positive patients. ( 29709461 )
2018
6
Role of ribavirin in the treatment of hepatitis C virus-associated mixed cryoglobulinemia with interferon-free regimens. ( 29318374 )
2018
7
The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia. ( 29910796 )
2018
8
Retreatment of symptomatic hepatitis C virus genotype 3 associated mixed cryoglobulinemia with sofosbuvir and ribavirin: a case report. ( 29904727 )
2018
9
Persistent mixed cryoglobulinemia after successful antiviral treatment of chronic hepatitis C virus infection: What's the next? ( 29966445 )
2018
10
Reversion of anergy signatures in clonal CD21(low) B cells of mixed cryoglobulinemia after clearance of HCV viremia. ( 28507081 )
2017
11
Micro and nanoparticles as possible pathogenetic co-factors in mixed cryoglobulinemia. ( 27694373 )
2017
12
Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia. ( 28453396 )
2017
13
MPGN and mixed cryoglobulinemia in a patient with hepatitis C - new treatment implications and renal outcomes. ( 29098140 )
2017
14
Thyroid Involvement in Hepatitis C Virus-Infected Patients with/without Mixed Cryoglobulinemia. ( 28736547 )
2017
15
Recurrent Mixed Cryoglobulinemia Despite Sustained Virologic Response to Treatment: A Case Report. ( 28343737 )
2017
16
Efficacy and Safety of Direct Acting Antivirals for the Treatment of Mixed Cryoglobulinemia. ( 28291241 )
2017
17
Systematic review of mixed cryoglobulinemia associated with hepatitis E virus infection: association or causation? ( 28852522 )
2017
18
Decline of cellular activation in non-B cells after rituximab treatment in hepatitis C-associated mixed cryoglobulinemia vasculitis. ( 27666584 )
2017
19
Lymphoproliferative disease with mixed cryoglobulinemia and hyperviscosity syndrome in an HIV-infected patient: HCV is the only culprit. ( 28825444 )
2017
20
Direct-Acting Antivirals and Mixed Cryoglobulinemia Vasculitis: Long-Term Outcome of Patients Achieving HCV Eradication. ( 29109502 )
2017
21
Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases. ( 28661098 )
2017
22
Mixed cryoglobulinemia: a diagnostic and therapeutic challenge. ( 28490478 )
2017
23
A Rare Cause of Unilateral Central Retinal Vein Occlusion in a Young Patient: Type III Mixed Cryoglobulinemia. ( 27418988 )
2016
24
Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia. ( 27139837 )
2016
25
Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study. ( 27161362 )
2016
26
Annular leukocytoclastic vasculitis associated with essential mixed cryoglobulinemia. ( 27098553 )
2016
27
Successful ledipasvira88+a88sofosbuvir treatment of active synovitis in a rheumatoid arthritis patient with hepatitis C virus-related mixed cryoglobulinemia. ( 27848256 )
2016
28
Mixed cryoglobulinemia-associated SjAPgren's syndrome leading to spontaneous rupture of the kidney: a case report. ( 27042145 )
2016
29
Hepatic and Mesenteric Vasculitis as Presenting Manifestation of Mixed Cryoglobulinemia Related to Chronic Hepatitis C Virus Infection in a Female Patient. ( 27219310 )
2016
30
The possible persistence of mixed cryoglobulinemia stigmata in spite of viral eradication: Insufficient or too late antiviral treatment? ( 27943334 )
2016
31
Prospective study of guideline-tailored therapy with direct-acting antivirals for hepatitis C virus-associated mixed cryoglobulinemia. ( 27483451 )
2016
32
Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study. ( 26853322 )
2016
33
Incidence of thyroid disorders in mixed cryoglobulinemia: Results from a longitudinal follow-up. ( 26970485 )
2016
34
Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report. ( 26785421 )
2016
35
Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review. ( 26031898 )
2015
36
Early onset mixed cryoglobulinemia in hepatitis C. ( 26275272 )
2015
37
The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation. ( 25452118 )
2015
38
Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents. ( 26474537 )
2015
39
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. ( 25800158 )
2015
40
Pulmonary Extranodal Marginal Zone Lymphoma with Macroglobulinemia and Mixed Cryoglobulinemia Developed in a Patient with Chronic Hepatitis C. ( 26278303 )
2015
41
Abnormal CD4a88+a88T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection. ( 26129991 )
2015
42
Treatment of HCV-related mixed cryoglobulinemia. ( 26302805 )
2015
43
Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and response to PEG-IFN and ribavirin treatment. ( 26060059 )
2015
44
Long-term effect of HCV eradication in patients with mixed cryoglobulinemia: A prospective, controlled, open-label, cohort study. ( 25431357 )
2015
45
Combined treatment with antiviral therapy and rituximab in patients with mixed cryoglobulinemia: review of the literature and report of a case using direct antiviral agents-based antihepatitis C virus therapy. ( 25815218 )
2015
46
Recurrent Mixed Cryoglobulinemia (MCS): A Case Report and Literature Review. ( 26422544 )
2015
47
Persistence of mixed cryoglobulinemia despite cure of hepatitis C with new oral antiviral therapy including direct-acting antiviral sofosbuvir: A case series. ( 25746436 )
2015
48
Vasculitis with renal involvement in essential mixed cryoglobulinemia: Case report and mini-review. ( 24868518 )
2014
49
Essential mixed cryoglobulinemia manifesting as recurrent perioral edema: report of a case. ( 24332336 )
2014
50
Treatment of chronic hepatitis C complicated by mixed cryoglobulinemia with new protease inhibitor, sofosbuvir. ( 25038237 )
2014

Variations for Cryoglobulinemia, Familial Mixed

Expression for Cryoglobulinemia, Familial Mixed

Search GEO for disease gene expression data for Cryoglobulinemia, Familial Mixed.

Pathways for Cryoglobulinemia, Familial Mixed

Pathways related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.73 IFNA1 IFNA2 TSLP
2 10.88 CD40LG CD5
3 10.25 IFNA1 IFNA2

GO Terms for Cryoglobulinemia, Familial Mixed

Cellular components related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD40LG CD5 IGHM
2 extracellular space GO:0005615 9.1 CD40LG ENO1 IFNA1 IFNA2 IGHM TSLP

Biological processes related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.65 IFNA1 IFNA2 IGHM
2 T cell costimulation GO:0031295 9.54 CD40LG CD5
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IFNA2 TSLP
4 type I interferon signaling pathway GO:0060337 9.51 IFNA1 IFNA2
5 humoral immune response GO:0006959 9.49 IFNA1 IFNA2
6 response to exogenous dsRNA GO:0043330 9.46 IFNA1 IFNA2
7 regulation of signaling receptor activity GO:0010469 9.46 CD40LG IFNA1 IFNA2 TSLP
8 regulation of type I interferon-mediated signaling pathway GO:0060338 9.43 IFNA1 IFNA2
9 positive regulation of interleukin-10 production GO:0032733 9.4 CD40LG TSLP
10 T cell activation involved in immune response GO:0002286 9.37 IFNA1 IFNA2
11 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.32 IFNA1 IFNA2
12 natural killer cell activation involved in immune response GO:0002323 9.26 IFNA1 IFNA2
13 B cell differentiation GO:0030183 9.13 CD40LG IFNA1 IFNA2
14 B cell proliferation GO:0042100 8.8 CD40LG IFNA1 IFNA2

Molecular functions related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IFNA1 IFNA2
2 type I interferon receptor binding GO:0005132 8.96 IFNA1 IFNA2
3 cytokine activity GO:0005125 8.92 CD40LG IFNA1 IFNA2 TSLP

Sources for Cryoglobulinemia, Familial Mixed

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