MCID: CRY014
MIFTS: 49

Cryptococcal Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Cryptococcal Meningitis

MalaCards integrated aliases for Cryptococcal Meningitis:

Name: Cryptococcal Meningitis 12 15 17
Meningitis, Cryptococcal 45 74
Meningitis Cryptococcal 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0080159
MeSH 45 D016919
UMLS 74 C0085436

Summaries for Cryptococcal Meningitis

Disease Ontology : 12 A fungal meningitis that has_material_basis in Crypococcus fungal infection.

MalaCards based summary : Cryptococcal Meningitis, also known as meningitis, cryptococcal, is related to meningitis and cryptococcosis. An important gene associated with Cryptococcal Meningitis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Miconazole and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and liver, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Cryptococcosis, also known as cryptococcal disease, is a potentially fatal fungal disease. It is caused... more...

Related Diseases for Cryptococcal Meningitis

Diseases related to Cryptococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 meningitis 32.3 ADA IFNG MBL2
2 cryptococcosis 30.7 IFNG MBL2
3 macroglobulinemia 29.4 TNFRSF13B TNFRSF13C TNFSF13B
4 systemic lupus erythematosus 29.3 FCGR2B IFNG MBL2 TNFRSF13B TNFRSF13C TNFSF13B
5 aids - neurological complications 11.3
6 acquired immunodeficiency syndrome 10.6
7 lupus erythematosus 10.4
8 hydrocephalus 10.4
9 leukemia 10.4
10 lymphopenia 10.4
11 intracranial hypertension 10.4
12 miliary tuberculosis 10.3 ADA IFNG
13 large granular lymphocyte leukemia 10.3 CSF2 IFNG
14 trichosporonosis 10.3 CSF2 IFNG
15 mucormycosis 10.3 CSF2 IFNG
16 pericardial tuberculosis 10.3 ADA IFNG
17 lymphocytic leukemia 10.3
18 candida glabrata 10.3 CSF2 IFNG
19 carotid artery thrombosis 10.3 CSF2 IFNG
20 human t-cell leukemia virus type 2 10.3 CSF2 IFNG
21 tuberculous peritonitis 10.3 ADA IFNG
22 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.3
23 stroke, ischemic 10.3
24 yemenite deaf-blind hypopigmentation syndrome 10.3
25 lymphoma 10.3
26 human immunodeficiency virus infectious disease 10.3
27 meconium aspiration syndrome 10.3 CSF2 IFNG
28 cyclic neutropenia 10.2 CSF2 IFNG
29 chronic graft versus host disease 10.2 IFNG TNFSF13B
30 human immunodeficiency virus type 1 10.2
31 hepatitis 10.2
32 congenital hydrocephalus 10.2
33 cytomegalovirus retinitis 10.2 CSF2 IFNG
34 pleural tuberculosis 10.2 ADA IFNG
35 leukemia, chronic lymphocytic 2 10.2
36 leukemia, chronic lymphocytic 10.2
37 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
38 leukemia, b-cell, chronic 10.2
39 extrapulmonary tuberculosis 10.2 ADA IFNG
40 toxoplasmosis 10.1
41 tuberculous meningitis 10.1
42 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 IFNG TNFSF13B
43 pulmonary tuberculosis 10.1 ADA IFNG MBL2
44 mycobacterium tuberculosis 1 10.1 ADA IFNG MBL2
45 pleurisy 10.1 ADA IFNG
46 aspergillosis 10.1 CSF2 IFNG MBL2
47 invasive aspergillosis 10.1 IFNG MBL2
48 bacterial infectious disease 10.1 CSF2 IFNG MBL2
49 behcet syndrome 10.1 ADA IFNG MBL2
50 multiple sclerosis 10.1

Comorbidity relations with Cryptococcal Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Cryptococcosis
Deficiency Anemia

Graphical network of the top 20 diseases related to Cryptococcal Meningitis:



Diseases related to Cryptococcal Meningitis

Symptoms & Phenotypes for Cryptococcal Meningitis

MGI Mouse Phenotypes related to Cryptococcal Meningitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 ADA ARRB2 CSF2 FCGR2B IFNG MBL2
2 homeostasis/metabolism MP:0005376 9.86 ADA ARRB2 CSF2 FCGR2B IFNG MBL2
3 immune system MP:0005387 9.85 ADA ARRB2 CSF2 FCGR2B IFNG MBL2
4 renal/urinary system MP:0005367 9.43 ADA CSF2 FCGR2B IFNG MBL2 TNFRSF13B
5 respiratory system MP:0005388 9.1 ADA ARRB2 CSF2 FCGR2B IFNG SRC

Drugs & Therapeutics for Cryptococcal Meningitis

Drugs for Cryptococcal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 22916-47-8 4189
2
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1397-89-3 5280965 14956
3
Fluconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 86386-73-4 3365
4
Lamivudine Approved, Investigational Phase 4,Not Applicable 134678-17-4 60825
5
Stavudine Approved, Investigational Phase 4,Not Applicable 3056-17-5 18283
6
Zidovudine Approved Phase 4 30516-87-1 35370
7
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
8
Nevirapine Approved Phase 4,Not Applicable 129618-40-2 4463
9
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
10
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
11 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Liposomal amphotericin B Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Cytochrome P-450 CYP2C19 Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
19 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Steroid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Anti-Retroviral Agents Phase 4,Not Applicable
25 Antiviral Agents Phase 4,Phase 2,Not Applicable
26 Anti-HIV Agents Phase 4,Not Applicable
27 Reverse Transcriptase Inhibitors Phase 4,Not Applicable
28 Cytochrome P-450 CYP3A Inducers Phase 4,Not Applicable
29 Nucleic Acid Synthesis Inhibitors Phase 4,Not Applicable
30 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
31 Liver Extracts Phase 4
32
Flucytosine Approved, Investigational Phase 2, Phase 3,Not Applicable 2022-85-7 3366
33
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 54677470 5281106
34
Sertraline Approved Phase 3 79617-96-2 68617
35
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
36 Antimetabolites Phase 2, Phase 3,Not Applicable
37 Anti-Inflammatory Agents Phase 3,Phase 2
38 Antirheumatic Agents Phase 3
39 Cyclooxygenase Inhibitors Phase 3
40 Anti-Inflammatory Agents, Non-Steroidal Phase 3
41 Analgesics Phase 3
42 Cyclooxygenase 2 Inhibitors Phase 3
43 Analgesics, Non-Narcotic Phase 3
44 Peripheral Nervous System Agents Phase 3,Phase 2
45 Neurotransmitter Agents Phase 3
46 Neurotransmitter Uptake Inhibitors Phase 3
47 Serotonin Uptake Inhibitors Phase 3
48 Serotonin Agents Phase 3
49 Antidepressive Agents Phase 3
50 Psychotropic Drugs Phase 3

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
2 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
3 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
4 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
5 Package of Care to Improve Retention in ART and Mortality Among Treatment Naive HIV Infected Individuals Active, not recruiting NCT03723525 Phase 4
6 Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa Unknown status NCT01715922 Phase 2, Phase 3 Fluconazole;Flucytosine
7 TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial Unknown status NCT02060006 Phase 3 Meloxicam 7.5mg daily for 8 weeks
8 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Completed NCT01802385 Phase 3 Sertraline
9 Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS Completed NCT00001017 Phase 3 Fluconazole;Amphotericin B
10 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
11 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
12 Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Not yet recruiting NCT03945448 Phase 2, Phase 3 Single dose liposomal Amphotericin and Fluconazole;Fluconazole
13 Cryptococcal Antigen Screening Plus Sertraline Terminated NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
14 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
15 Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis Completed NCT00145249 Phase 2 Amphotericin B;Fluconazole
16 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
17 Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis Completed NCT00012467 Phase 2 Itraconazole;Flucytosine;Fluconazole;Amphotericin B;Interferon gamma-1b
18 A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000975 Phase 2 Itraconazole
19 Treatment With Tamoxifen in Cryptococcal Meningitis Active, not recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
20 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00847678 Phase 2
21 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00324025 Phase 2 Mycograb;placebo
22 Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection Terminated NCT01562132 Phase 2 Flucytosine and fluconazole;Fluconazole
23 Efficacy and Safety of Oral Encochleated Amphotericin B for the Treatment of Cryptococcal Infection Withdrawn NCT03196921 Phase 1, Phase 2 Encochleated Amphotericin B
24 SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance Therapy Completed NCT00000677 Phase 1 SCH 39304
25 The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis Completed NCT00002316 Phase 1 Lobradimil;Amphotericin B
26 Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report Completed NCT02955862 Phase 1
27 Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis Unknown status NCT02136030 Not Applicable Liposomal amphotericin B;Amphotericin B-deoxycholate
28 Early Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in Africa Completed NCT00830856 Not Applicable Fluconazole;Fixed dose - Stavudine, lamivudine and Nevirapine;Fixed dose - Stavudine, Lamivudine, Nevirapine
29 Clinical Outcomes of Cryptococcal Meningitis Among HIV-infected Patients in the Era of Antiretroviral Therapy Completed NCT02098525
30 Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00000708 Not Applicable Flucytosine;Fluconazole;Amphotericin B
31 A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis Completed NCT00002305 Not Applicable Flucytosine;Fluconazole;Amphotericin B
32 Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002076 Not Applicable Fluconazole
33 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00002075 Not Applicable Flucytosine;Fluconazole;Amphotericin B
34 A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00002068 Not Applicable Fluconazole;Amphotericin B
35 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDS Completed NCT00002294 Not Applicable Fluconazole
36 Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00002019 Not Applicable Amphotericin B, Lipid-based;Amphotericin B
37 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B Completed NCT00002306 Not Applicable Fluconazole
38 A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00000639 Not Applicable Itraconazole;Flucytosine;Fluconazole;Amphotericin B
39 An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002077 Not Applicable Fluconazole
40 Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002040 Not Applicable Fluconazole
41 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome Completed NCT00002074 Not Applicable Fluconazole;Amphotericin B
42 A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis. Completed NCT00002113 Not Applicable Flucytosine;Fluconazole
43 CryptoART Study: Decreasing Mortality Associated With Initiation of Antiretroviral Therapy in Sub-Saharan Africa Completed NCT02434172
44 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
45 Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia Recruiting NCT00867269
46 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Active, not recruiting NCT02624453 Not Applicable Fluconazole;Antiretroviral therapy
47 Vietnam Cryptococcal Retention in Care Study - Version 2.1 Active, not recruiting NCT03267407
48 Vietnam Cryptococcal Retention in Care Study Version 1.0 Active, not recruiting NCT02334670 Fluconazole

Search NIH Clinical Center for Cryptococcal Meningitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: meningitis, cryptococcal

Genetic Tests for Cryptococcal Meningitis

Anatomical Context for Cryptococcal Meningitis

MalaCards organs/tissues related to Cryptococcal Meningitis:

42
T Cells, Testes, Liver, Bone, Brain, Pituitary, B Cells

Publications for Cryptococcal Meningitis

Articles related to Cryptococcal Meningitis:

(show top 50) (show all 1109)
# Title Authors Year
1
Cryptococcal Meningitis in a HIV Seronegative Patient: A Rare Complication of Cerebrospinal Fluid Leak Detected with a New Cisternographic Technique. ( 30915245 )
2019
2
Shedding light on IRIS: from Pathophysiology to Treatment of Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome in HIV-Infected Individuals. ( 30362282 )
2019
3
Emerging concepts in HIV-associated cryptococcal meningitis. ( 30507673 )
2019
4
Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies. ( 30565753 )
2019
5
A Comparison of the Clinical Characteristics and Outcomes of Cryptococcal Meningitis in HIV-negative Individuals With and Without Immunosuppression. ( 30586025 )
2019
6
CRYPTOCOCCAL meningitis in a HIV negative newly diagnosed diabetic patient: a CASE report. ( 30606110 )
2019
7
Correction to: AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial. ( 30642386 )
2019
8
Lacunar Stroke in Cryptococcal Meningitis: Clinical and Radiographic Features. ( 30655043 )
2019
9
Unique clinical features of cryptococcal meningitis among Chinese patients without predisposing diseases against patients with predisposing diseases. ( 30657946 )
2019
10
Importance of fibrosis 4 index score and mode of anti-fungal treatment to the outcome of Cryptococcal meningitis in hepatitis B virus-infected patients. ( 30676149 )
2019
11
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. ( 30688656 )
2019
12
Factors affecting mortality among HIV positive patients two years after completing recommended therapy for Cryptococcal meningitis in Uganda. ( 30699151 )
2019
13
Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis. ( 30753074 )
2019
14
Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker. ( 30767376 )
2019
15
A randomized open label trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis. ( 30801037 )
2019
16
Addition of flucytosine to fluconazole for the treatment of cryptococcal meningitis in Africa: a multi-country cost-effectiveness analysis. ( 30816418 )
2019
17
29 Cryptococcal Meningitis Leading to Fatal Outcomes in Immunocompetent Patients: A Case Study and Review of Literature. ( 30859958 )
2019
18
Cryptococcal Meningitis and Anti-virulence Therapeutic Strategies. ( 30863389 )
2019
19
Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa. ( 30863852 )
2019
20
Letter to Editor on "Lacunar Stroke in Cryptococcal Meningitis: Clinical and Radiographic Features". ( 30885460 )
2019
21
Response to Ajay Kumar Mishra, et al. Lacunar strokes in Cryptococcal meningitis. ( 30898446 )
2019
22
The clinical characteristics and therapeutic outcomes of cryptococcal meningitis in elderly patients: a hospital-based study. ( 30909914 )
2019
23
Successful Management of Cryptococcal Meningitis and Bone Marrow Infiltration in a Young HIV/AIDS Patient: A Case Report and Review of the Literature. ( 30915244 )
2019
24
A case report of disseminated histoplasmosis and concurrent cryptococcal meningitis in a patient treated with ruxolitinib. ( 30917797 )
2019
25
AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: economic evaluation protocol for a randomised controlled trial-based equivalence study. ( 30940760 )
2019
26
Cryptococcal Meningitis in an Apparent Immunocompetent Patient. ( 30947544 )
2019
27
Clinical Reasoning: A 71-year-old man receiving treatment for cryptococcal meningitis, developing new-onset lethargy. ( 31010911 )
2019
28
Vision loss in an AIDS patient with cryptococcal meningitis. ( 31032178 )
2019
29
Cryptococcal meningitis after ART: Need for proper baseline evaluation in the era of 'Test & Treat'. ( 31049279 )
2019
30
Cryptococcal meningitis initially presenting with ST elevations and elevated cardiac biomarkers. ( 31068342 )
2019
31
Discovery of Novel Simplified Sampangine Derivatives with Potent Antifungal Activities against Cryptococcal Meningitis. ( 31070884 )
2019
32
IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME CAUSING PROGRESSIVE OPTIC NERVE EDEMA IN CRYPTOCOCCAL MENINGITIS. ( 28333858 )
2019
33
Comparison of Clinical Features and Prognostic Factors of Cryptococcal Meningitis Caused by Cryptococcus neoformans in Patients With and Without Pulmonary Nodules. ( 29737452 )
2019
34
Burden of acute kidney injury in HIV patients under deoxycholate amphotericin B therapy for cryptococcal meningitis and cost-minimization analysis of amphotericin B lipid complex. ( 29762761 )
2019
35
Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial. ( 29945252 )
2019
36
Understanding Causal Pathways in Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome. ( 30010897 )
2019
37
The Cerebellar Leptomeningeal Enhancement Associated with Cryptococcal Meningitis. ( 30101946 )
2019
38
Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing. ( 30257903 )
2019
39
Serum cryptococcal antigen titre as a diagnostic tool and a predictor of mortality in HIV-infected patients with cryptococcal meningitis. ( 30311440 )
2019
40
Cryptococcal meningitis following umbilical cord blood transplantation, association between the occurrence of cryptococcal infection and tacrolimus discontinuation among allogeneic hematopoietic stem cell recipients. ( 30316744 )
2019
41
HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts. ( 30325463 )
2019
42
Ophthalmic signs in Ugandan adults with HIV-associated cryptococcal meningitis: A nested analysis of the ASTRO-CM cohort. ( 30345376 )
2018
43
Cryptococcal meningitis mimicking cerebral infarction: a case report. ( 30349219 )
2018
44
Genetic influence of Toll-like receptors on non-HIV cryptococcal meningitis: An observational cohort study. ( 30366814 )
2018
45
AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial. ( 30470259 )
2018
46
Correction for Stott et al., "Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis". ( 30478182 )
2018
47
Correction for Stott et al., "Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis". ( 30478183 )
2018
48
High Mortality in HIV-Associated Cryptococcal Meningitis Patients Treated With Amphotericin B-Based Therapy Under Routine Care Conditions in Africa. ( 30488038 )
2018
49
Molecular types of Cryptococcus species isolated from patients with cryptococcal meningitis in a Brazilian tertiary care hospital. ( 30508502 )
2018
50
High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis. ( 30541454 )
2018

Variations for Cryptococcal Meningitis

Expression for Cryptococcal Meningitis

Search GEO for disease gene expression data for Cryptococcal Meningitis.

Pathways for Cryptococcal Meningitis

Pathways related to Cryptococcal Meningitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 ARRB2 CSF2 FCGR2B IFNG MBL2 SRC
2
Show member pathways
13.42 CSF2 IFNG SRC TNFRSF13B TNFRSF13C TNFSF13B
3
Show member pathways
13.08 CSF2 SRC TNFRSF13B TNFRSF13C TNFSF13B YWHAG
4
Show member pathways
13.01 CSF2 SRC TNFRSF13B TNFRSF13C TNFSF13B
5
Show member pathways
12.63 IFNG TNFRSF13B TNFRSF13C TNFSF13B
6
Show member pathways
12.28 ARRB2 CSF2 IFNG SRC TNFRSF13B TNFRSF13C
7
Show member pathways
12.19 SRC TNFRSF13B TNFRSF13C TNFSF13B YWHAG
8
Show member pathways
12.07 SRC TNFRSF13B TNFRSF13C TNFSF13B
9 11.97 FCGR2B IFNG SRC
10 11.87 ARRB2 SRC YWHAG
11
Show member pathways
11.79 CSF2 FCGR2B IFNG
12
Show member pathways
11.79 IFNG SRC TNFRSF13C TNFSF13B
13 11.57 CSF2 IFNG TNFSF13B
14 11.43 CSF2 FCGR2B IFNG
15 11.26 ARRB2 SRC
16 11.12 ARRB2 SRC
17 11.08 SRC YWHAG
18 11.04 TNFRSF13B TNFSF13B
19 11.02 CSF2 IFNG
20 10.9 ADA TNFRSF13B TNFRSF13C
21 10.65 CSF2 SRC TNFRSF13B
22 10.64 ARRB2 SRC

GO Terms for Cryptococcal Meningitis

Biological processes related to Cryptococcal Meningitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.86 CSF2 FCGR2B IFNG TNFSF13B
2 regulation of signaling receptor activity GO:0010469 9.85 CSF2 FCGR2B IFNG TNFSF13B
3 positive regulation of gene expression GO:0010628 9.84 ARRB2 CSF2 IFNG SRC
4 immune system process GO:0002376 9.83 MBL2 SRC TNFRSF13B TNFRSF13C TNFSF13B
5 regulation of immune response GO:0050776 9.74 FCGR2B TNFRSF13C TNFSF13B
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.65 TNFRSF13B TNFRSF13C TNFSF13B
7 positive regulation of phagocytosis GO:0050766 9.58 FCGR2B MBL2
8 positive regulation of epithelial cell migration GO:0010634 9.58 IFNG SRC
9 T cell costimulation GO:0031295 9.54 SRC TNFRSF13C TNFSF13B
10 negative regulation of B cell proliferation GO:0030889 9.52 FCGR2B TNFRSF13B
11 positive regulation of DNA biosynthetic process GO:2000573 9.51 ARRB2 SRC
12 positive regulation of podosome assembly GO:0071803 9.49 CSF2 SRC
13 regulation of circadian sleep/wake cycle, sleep GO:0045187 9.46 ADA CSF2
14 positive regulation of interleukin-23 production GO:0032747 9.4 CSF2 IFNG
15 positive regulation of B cell proliferation GO:0030890 9.33 ADA TNFRSF13C TNFSF13B
16 histamine secretion GO:0001821 9.32 ADA CSF2
17 B cell costimulation GO:0031296 9.26 TNFRSF13C TNFSF13B
18 B cell homeostasis GO:0001782 9.13 TNFRSF13B TNFRSF13C TNFSF13B
19 positive regulation of germinal center formation GO:0002636 8.8 ADA TNFRSF13C TNFSF13B

Molecular functions related to Cryptococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 CSF2 IFNG TNFSF13B
2 signaling receptor binding GO:0005102 8.92 ARRB2 MBL2 SRC TNFSF13B

Sources for Cryptococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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