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MCID: CRY005
MIFTS: 61

Cryptococcosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Cryptococcosis

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MalaCards integrated aliases for Cryptococcosis:

Name: Cryptococcosis 11 19 58 75 53 43 14 16 31 33
Cryptococcus Neoformans Infection 11 33
Torulosis 11 33
Infection by Cryptococcus Neoformans 71
European Blastomycotic Infection 33
European Blastomycoses Infection 33
Torula Histolytica Infection 33
Cryptococcosis Infection 33
Busse-Buschke's Disease 11
European Cryptococcosis 11
Cryptococcal Infection 11
European Blastomycosis 33
Torula 11

Characteristics:


Prevelance:

1-5/10000 (Europe) 58

Age Of Onset:

All ages 58

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 31 32
ICD11: 33
Orphanet: 58  
Rare infectious diseases


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Summaries for Cryptococcosis

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Disease Ontology: 11 An opportunistic mycosis that results in fungal infection and has material basis in Cryptococcus neoformans or Cryptococcus gattii.

MalaCards based summary: Cryptococcosis, also known as cryptococcus neoformans infection, is related to meningitis and acquired immunodeficiency syndrome. An important gene associated with Cryptococcosis is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and Complement cascade. The drugs Voriconazole and Cytochrome P-450 CYP3A Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and bone marrow, and related phenotypes are fever and immunodeficiency

GARD: 19 A cosmopolitan fungal infection due to Cryptococcus neoformans.

Orphanet: 58 A cosmopolitan fungal infection due to Cryptococcus neoformans.

Wikipedia: 75 Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia,... more...
Sources

Related Diseases for Cryptococcosis

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Diseases related to Cryptococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 977)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.5 TNF MBL2 IL4 IL17A IFNG FCGR2A
2 acquired immunodeficiency syndrome 31.3 TNF IFNG FCGR3A CSF2 CD4
3 lymphopenia 31.0 SELL IL4 IFNG CCR6
4 meningoencephalitis 30.8 TNF PLB1 CD8A CD4 CCR6 CARD9
5 pulmonary tuberculosis 30.7 TNF MBL2 IL4 IFNG
6 cryptococcal meningitis 30.7 ZNF2 TNF PLB1 IL4 IL17A IFNG
7 histoplasmosis 30.5 TNF IFNG CLEC7A CLEC6A CD4 CCR6
8 osteomyelitis 30.5 TNF IL4 IFNG
9 cellulitis 30.5 TNF IL17A CSF2 CD8A CD4 CCR6
10 lymphadenitis 30.5 TNF PTX3 IFNG CCR6
11 miliary tuberculosis 30.4 TNF IL4 IFNG CD8A CD4
12 thrombocytopenia due to platelet alloimmunization 30.4 FCGR2A CD8A CD4 CCR6
13 thrombocytopenic purpura, autoimmune 30.4 FCGR2A CD8A CD4 CCR6
14 sarcoidosis 1 30.4 TNF IL17A IFNG CD8A CD4 CCR6
15 adult respiratory distress syndrome 30.4 TNF SELL FCGR2A CCR6
16 tinea capitis 30.4 CLEC7A CLEC6A CD4 CARD9
17 aspergillosis 30.4 TNF PTX3 MBL2 IL4 IFNG CSF2
18 toxoplasmosis 30.3 TNF IL4 IL17A IFNG
19 peritonitis 30.3 TNF SELL IL17A IFNG FCGR3B
20 immunodeficiency with hyper-igm, type 1 30.3 IL4 CD4 CCR6
21 pleural tuberculosis 30.3 TNF IFNG CD4
22 toxic shock syndrome 30.3 TNF IL4 IFNG
23 adult t-cell leukemia/lymphoma 30.3 CD8A CD4 CCR6
24 candida glabrata 30.3 IFNG CSF2
25 alcohol use disorder 30.3 TNF CD4 CCR6
26 penicilliosis 30.2 IFNG CLEC7A CD4 CARD9
27 pyoderma 30.2 TNF IL17A CCR6
28 angioimmunoblastic t-cell lymphoma 30.2 CD8A CD4 CCR6
29 lymph node tuberculosis 30.2 TNF IFNG CD4
30 diphtheria 30.2 TNF IL4 IFNG CSF2
31 vasculitis 30.2 TNF SELL PTX3 MBL2 IL17A FCGR3B
32 rhinitis 30.2 TNF IL4 IL17A IFNG CSF2
33 candidiasis 30.2 TNF MBL2 IL4 IL17A IFNG CSF2
34 laryngitis 30.2 TNF IL4 CD4
35 lung disease 30.2 TNF MBL2 IFNG CSF2 CCR6
36 bronchopneumonia 30.1 TNF IL17A CD8A CD4
37 urinary tract infection 30.1 TNF CD4 CCR6
38 trichosporonosis 30.1 PTX3 CLEC7A CARD9
39 endophthalmitis 30.1 TNF CD4 CARD9
40 arachnoiditis 30.1 TNF IFNG CD4
41 pneumonia 30.1 TNF MBL2 IL4 IL17A IFNG CSF2
42 bronchiolitis obliterans 30.1 TNF IL17A IFNG
43 intestinal schistosomiasis 30.0 TNF IL4 IL17A CD4 CCR6
44 herpes zoster 30.0 IFNG FCGR3A FCGR2A CD8A CD4 CCR6
45 myasthenia gravis 30.0 TNF IL4 IFNG FCGR2A
46 henoch-schoenlein purpura 30.0 TNF CD4 CCR6
47 pancytopenia 30.0 IFNG CSF2 CD8A CD4
48 chorioretinitis 30.0 TNF IL17A IFNG CD8A CD4 CCR6
49 ocular tuberculosis 30.0 IFNG CD4
50 granulocytopenia 30.0 SELL CSF2

Comorbidity relations with Cryptococcosis via Phenotypic Disease Network (PDN):


Acute Cystitis Cryptococcal Meningitis
Deficiency Anemia

Graphical network of the top 20 diseases related to Cryptococcosis:



Diseases related to Cryptococcosis
Sources

Symptoms & Phenotypes for Cryptococcosis

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Human phenotypes related to Cryptococcosis:

58 30 (show all 42)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001945
2 immunodeficiency 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002721
3 cough 58 30 Frequent (33%) Frequent (79-30%)
 HP:0012735
4 nodular pattern on pulmonary hrct 58 30 Frequent (33%) Frequent (79-30%)
 HP:0025392
5 hydrocephalus 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000238
6 behavioral abnormality 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000708
7 increased intracranial pressure 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002516
8 vomiting 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002013
9 cirrhosis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001394
10 cerebral cortical atrophy 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002120
11 mental deterioration 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001268
12 chest pain 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0100749
13 meningitis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001287
14 headache 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002315
15 mediastinal lymphadenopathy 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0100721
16 respiratory distress 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002098
17 limb muscle weakness 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0003690
18 pneumonia 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002090
19 pleural effusion 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002202
20 systemic lupus erythematosus 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002725
21 nuchal rigidity 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0031179
22 seizure 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0001250
23 blindness 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000618
24 ophthalmoplegia 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000602
25 abnormal cranial nerve morphology 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0001291
26 osteomyelitis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0002754
27 sepsis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0100806
28 memory impairment 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0002354
29 osteolysis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0002797
30 prostatitis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000024
31 peritonitis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0002586
32 abnormality of the optic nerve 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000587
33 abnormality of the outer ear 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000356
34 abnormal retinal morphology 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000479
35 cerebral edema 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0002181
36 vitritis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0011531
37 lymphoid leukemia 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0005526
38 autoimmunity 58 Occasional (29-5%)
39 dyspnea 58 Occasional (29-5%)
40 neoplasm 58 Occasional (29-5%)
41 abnormality of the eye 58 Occasional (29-5%)
42 abnormality of vision 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Cryptococcosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 CARD9 CCR6 CD4 CLEC7A CSF2 FCGR2A
2 immune system MP:0005387 10.09 CARD9 CCR6 CD4 CD8A CLEC6A CLEC7A
3 no phenotypic analysis MP:0003012 10.01 CD4 CLEC6A FCGR3A FCGR3B IFNG IL17A
4 renal/urinary system MP:0005367 9.97 CD8A CLEC6A CSF2 FCGR2A IFNG IL17A
5 endocrine/exocrine gland MP:0005379 9.96 CD4 CD8A CSF2 FCGR2A IFNG IL17A
6 respiratory system MP:0005388 9.61 CLEC7A CSF2 FCGR2A IFNG IL17A IL4
7 hematopoietic system MP:0005397 9.55 CARD9 CCR6 CD4 CD8A CLEC6A CLEC7A
Sources

Drugs & Therapeutics for Cryptococcosis

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Drugs for Cryptococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Voriconazole Approved Phase 4 137234-62-9 71616
2 Cytochrome P-450 CYP3A Inhibitors Phase 4
3
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
4
Sertraline Approved Phase 3 79617-96-2 68617
5 Pharmaceutical Solutions Phase 3
6
Hydroxyitraconazole Phase 3 108222
7 Neurotransmitter Agents Phase 3
8 Psychotropic Drugs Phase 3
9 Antidepressive Agents Phase 3
10 Serotonin Uptake Inhibitors Phase 3
11
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
12
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
13
Flucytosine Approved, Investigational Phase 2 2022-85-7 3366
14 Hormones Phase 2
15 Hormone Antagonists Phase 2
16 Cytochrome P-450 Enzyme Inhibitors Phase 2
17 Antimetabolites Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 An Open Label, Non-comparative, Multicenter Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infection Completed NCT00647907 Phase 4 Voriconazole
2 Operational Research for Cryptococcal Antigen Screening to Improve ART Survival Completed NCT01535469 Phase 4 Fluconazole
3 Safety, Efficacy, and Pharmacokinetics of Amphotericin B Lipid Complex at 10 mg/kg/d for 7 Days or 5.0 mg/kg/d for 14 Days as Induction Therapy for Disseminated Cryptococcosis in Patients With HIV Withdrawn NCT01656382 Phase 4 ABLC
4 Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis. Open Label Phase III Clinical Study Unknown status NCT01125644 Phase 3 SPK-843
5 A Pharmacokinetic Study of JK1211 in Patients With Systemic Fungal Infection (SFI) and Patients With Febrile Neutropenia (FN) Suspected of Fungal Infection. Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
6 Cryptococcal Antigen Screening Plus Sertraline Terminated NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
7 An Open Label Randomized Controlled Phase IIb Trial to Determine the Safety of Oral Fluconazole in Combination With Flucytosine as Compared to Fluconazole Alone Terminated NCT01562132 Phase 2 Flucytosine and fluconazole;Fluconazole
8 A Prospective Cohort to Evaluate the Efficacy and Safety of Oral Encochleated Amphotericin B (CAMB/MAT2203) for the Treatment of Cryptococcal Infection Withdrawn NCT03196921 Phase 1, Phase 2 Encochleated Amphotericin B
9 Derivation and Validation of a Scoring System to Distinguish Cryptococcosis and Adenocarcinoma in Pulmonary Nodules: a Multicenter Observational Study. Unknown status NCT04554875
10 Multi-center Clinical Trial of Pulmonary Cryptococcosis in China Unknown status NCT02503449
11 Vietnam Cryptococcal Retention in Care Study (CRICS) - Version 2.1 Unknown status NCT03267407
12 AIDS Defining Opportunistic Infections in Naive HIV Cases Completed NCT03993093
13 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection Completed NCT00001701
14 Cryptococcosis in Previously Healthy Adults Recruiting NCT00001352
15 Vicente Ferrer HIV Cohort Study Recruiting NCT02454569
16 Inpatient Package to Reduce HIV and AIDS-related Death in Zambia Recruiting NCT04033718

Search NIH Clinical Center for Cryptococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Itraconazole

Cochrane evidence based reviews: cryptococcosis

Sources

Genetic Tests for Cryptococcosis

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Anatomical Context for Cryptococcosis

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Organs/tissues related to Cryptococcosis:

MalaCards : Brain, Skin, Bone Marrow, Lung, Eye, Lymph Node, Liver
Sources

Publications for Cryptococcosis

About this section

Articles related to Cryptococcosis:

(show top 50) (show all 6813)
# Title Authors PMID Year
1
Levels of L-selectin (CD62L) on human leukocytes in disseminated cryptococcosis with and without associated HIV-1 infection. 53 62
15776384 2005
2
Imaging of Uncommon Bacterial, Rickettsia, Spirochete, and Fungal Infections. 62
36404049 2023
3
Antifungal susceptibility of the clinical and environmental strains of Cryptococcus gattii sensu lato in Taiwan. 62
35986599 2023
4
Cryptococcal Antigen Screening and Missed Opportunities for Earlier Diagnosis Among People With HIV and Poor Virologic Control in the Bronx, NY. 62
35952358 2022
5
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain. 62
35621025 2022
6
A fatal disseminated cryptococcal infection in a patient treated with zanubrutinib for Waldenström's macroglobulinemia. 62
35306909 2022
7
Asymptomatic pulmonary cryptococcosis presenting with mixed lesions of infiltrative and nodular shadow in an immunocompromised patient. 62
36455984 2022
8
The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis. 62
36049486 2022
9
Pulmonary Co-infection with Cryptococcus Species and Pneumocystis jirovecii in an Old Patient Without a Previous Predisposing Illness. 62
35939225 2022
10
The global burden of cryptococcosis-a neglected tropical disease? 62
36049487 2022
11
Cryptococcosis by Cryptococcus sp. Causing Lymphadenomegaly as a Single Sign in a Cat. 62
36167918 2022
12
Chronic disseminated cryptococcosis without meningeal involvement in a severely immunosuppressed HIV-infected patient successfully treated with fluconazole. 62
36345352 2022
13
Trend of pediatric cryptococcosis in a tertiary care centre and review of literature. 62
36464534 2022
14
Characteristics and Outcomes of Cryptococcosis among Patients with and without COVID-19. 62
36422055 2022
15
Disseminated cryptococcosis in a renal failure patient diagnosed by examination of a peripheral blood smear. 62
36350268 2022
16
Incidental diagnosis of pulmonary cryptococcosis by rebiopsy for epidermal growth factor receptor T790M mutation: A case report. 62
36450693 2022
17
Clinical features, outcomes, and long-term survival times of cats and dogs with central nervous system cryptococcosis in Australia: 50 cases (2000-2020). 62
36434766 2022
18
Video-assisted thoracoscopic surgery for primary pulmonary cryptococcosis. 62
35501211 2022
19
Non-healing cutaneous ulcer as the initial presentation of disseminated cryptococcosis. 62
35962501 2022
20
Disseminated Cryptococcosis Masquerading as a Large Abdominal Mass Concerning for Pancreatic Malignancy in an HIV-Positive Patient. 62
36382333 2022
21
Comparison of the clinical manifestations and chest CT findings of pulmonary cryptococcosis in immunocompetent and immunocompromised patients: a systematic review and meta-analysis. 62
36369001 2022
22
Cryptococcosis after heart transplantation: A literature review and case report. 62
36380506 2022
23
Disseminated Cryptococcosis in a Patient with CD40 Ligand Deficiency. 62
35932410 2022
24
Using infrared spectroscopy of serum and chemometrics for diagnosis of paracoccidioidomycosis. 62
36113324 2022
25
Ectopic adrenocorticotropic hormone-secreting carcinoid with solitary cryptococcosis in the lungs. 62
36196010 2022
26
Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome. 62
36354332 2022
27
Cryptococcus gattii Infection as the Major Clinical Manifestation in Patients with Autoantibodies Against Granulocyte-Macrophage Colony-Stimulating Factor. 62
35947322 2022
28
Clinical performance of the IMMY cryptococcal antigen lateral flow assay in dogs and cats. 62
36254569 2022
29
Extension of O-Linked Mannosylation in the Golgi Apparatus Is Critical for Cell Wall Integrity Signaling and Interaction with Host Cells in Cryptococcus neoformans Pathogenesis. 62
36409123 2022
30
A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection. 62
36367554 2022
31
The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans. 62
36416414 2022
32
Metagenomic next-generation sequencing contributes to the diagnosis of mixed pulmonary infection: a case report. 62
36434704 2022
33
Tephritid Fruit Fly Species Composition, Seasonality, and Fruit Infestations in Two Central African Agro-Ecological Zones. 62
36421948 2022
34
Evaluation of Torula yeast as a protein source in extruded feline diets. 62
36209420 2022
35
Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans. 62
36302775 2022
36
Engineered Fluorescent Strains of Cryptococcus neoformans: a Versatile Toolbox for Studies of Host-Pathogen Interactions and Fungal Biology, Including the Viable but Nonculturable State. 62
36005449 2022
37
Modification of Hinge/Transmembrane and Signal Transduction Domains Improves the Expression and Signaling Threshold of GXMR-CAR Specific to Cryptococcus spp. 62
36359781 2022
38
The Cryptococcus neoformans Flc1 Homologue Controls Calcium Homeostasis and Confers Fungal Pathogenicity in the Infected Hosts. 62
36169198 2022
39
Diffuse Adrenal Gland and Pancreas Necrosis in a Patient with Disseminated Cryptococcosis-Case Report. 62
36295101 2022
40
A lateral flow assay for the immunodiagnosis of human cat-transmitted sporotrichosis. 62
35943444 2022
41
Cryptococcus neoformans Infection in the Central Nervous System: The Battle between Host and Pathogen. 62
36294634 2022
42
Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis. 62
36221098 2022
43
Cryptococcal Pneumonia in an Immunocompetent Patient: A Rare Occurrence. 62
36348868 2022
44
Efficacy and safety of isavuconazole against deep-seated mycoses: A phase 3, randomized, open-label study in Japan. 62
36307059 2022
45
Recurrence of symptoms following cryptococcal meningitis - characterizing a diagnostic conundrum with multiple etiologies. 62
36303432 2022
46
Too much of a good thing: Immune reconstitution inflammatory syndrome in a patient with Still's disease. 62
36268454 2022
47
Investigation of CryptoPS LFA-positive sera in patients at risk of cryptococcosis. 62
36149324 2022
48
Pulmonary Cryptococcosis. 62
36354923 2022
49
Miliary Pulmonary Cryptococcosis in IgG4-related Disease. 62
36288984 2022
50
Disseminated cryptococcosis mimicking malignant lymphoma on 18F-FDG PET/CT: A case report. 62
36316948 2022
Sources

Variations for Cryptococcosis

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Expression for Cryptococcosis

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Search GEO for disease gene expression data for Cryptococcosis.
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Pathways for Cryptococcosis

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Pathways related to Cryptococcosis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.64 TNF SELL PTX3 MBL2 IL4 IL17A
2
Complement cascade 66
Show member pathways
 12.58 SELL PTX3 MBL2 IFNG FCGR3A
3
NF-kappaB Signaling 3
12.49 TNF IL4 IL17A IFNG CD8A CARD9
4
Immune response CD16 signaling in NK cells 22
Show member pathways
 12.13 CSF2 FCGR3A IFNG IL4 TNF
5
T-cell activation SARS-CoV-2 74
Show member pathways
 11.98 CD4 CD8A CSF2 IFNG IL17A IL4
6
Spinal cord injury 74
11.97 TNF IL4 IFNG FCGR2A
7
IL12-mediated signaling events 61
Show member pathways
 11.94 CD4 CD8A IFNG IL4
8
IL27-mediated signaling events 61
Show member pathways
 11.89 TNF IL17A IFNG CD4
9
Allograft rejection 74
11.85 TNF IL4 IL17A IFNG
10
Th17 Differentiation 65
Show member pathways
 11.84 IL4 IL17A IFNG CD4
11
Glucocorticoid receptor regulatory network 61
11.75 IL4 IFNG FCGR2A CSF2
12
Activation of NF-KappaB by PKR 64
Show member pathways
 11.73 TNF IFNG FCGR2A
13
Extrafollicular B cell activation by SARS-CoV-2 74
11.71 TNF SELL IL4 IFNG
14
Th17 cell differentiation pathway 74
11.69 IL4 IL17A IFNG CD4
15
Dendritic Cells Developmental Lineage Pathway 65
11.67 TNF SELL IFNG CSF2 CD8A CD4
16
AP-1 transcription factor network 61
11.66 IL4 IFNG CSF2
17
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 61
Show member pathways
 11.66 TNF IL4 IFNG CSF2
18
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.62 TNF IFNG CSF2
19
Lung fibrosis 74
11.62 TNF PTX3 IL4 CSF2
20
Inflammatory bowel disease signaling 74
Show member pathways
 11.58 TNF IL4 IFNG
21
THC Differentiation Pathway 64
11.51 TNF IL4 IFNG CD4
22
Th2 Differentiation 65
11.47 IL4 IFNG CD4
23
Innate Lymphoid Cells Differentiation 65
11.4 TNF IL4 IL17A IFNG CD8A CD4
24
Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction 60
11.37 FCGR3A FCGR2A CD4
25
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
Show member pathways
 11.35 TNF IFNG CSF2
26
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.29 TNF SELL IL4 IFNG FCGR2A CSF2
27
Development and heterogeneity of the ILC family 74
11.28 TNF IL4 IL17A IFNG
28
Cytokines and inflammatory response 74
11.26 TNF IL4 IFNG CSF2 CD4
29
Immune infiltration in pancreatic cancer 74
11.2 TNF IL4 IL17A IFNG CSF2
30
Interactions of natural killer cells in pancreatic cancer 74
11.19 TNF IFNG FCGR3A CSF2
31
Selective expression of chemokine receptors during T-cell polarization 74
10.91 IL4 IFNG CSF2 CD4
Sources

GO Terms for Cryptococcosis

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Cellular components related to Cryptococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.03 TNF SELL FCGR3B FCGR3A FCGR2A CD8A
2 plasma membrane GO:0005887 10.03 TNF SELL FCGR3B FCGR3A FCGR2A CD8A
3 external side of plasma membrane GO:0009897 9.53 TNF MBL2 IL17A FCGR3A CLEC6A CD8A

Biological processes related to Cryptococcosis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.38 CARD9 CD4 CD8A CLEC6A IFNG IL17A
2 cell surface receptor signaling pathway GO:0007166 10.35 IFNG FCGR3B FCGR3A FCGR2A CD8A CD4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.3 TNF CLEC7A CLEC6A CD4 CARD9
4 defense response to Gram-positive bacterium GO:0050830 10.24 TNF MBL2 IL17A CARD9
5 calcium-mediated signaling GO:0019722 10.22 CCR6 CD4 FCGR3A TNF
6 positive regulation of cytokine production GO:0001819 10.16 TNF IFNG CLEC6A CARD9
7 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 10.14 TNF CLEC7A CARD9
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.14 TNF IL4 IFNG CSF2
9 positive regulation of chemokine production GO:0032722 10.13 TNF IFNG CARD9
10 positive regulation of interleukin-12 production GO:0032735 10.13 IL17A IFNG CLEC7A
11 positive regulation of interleukin-1 beta production GO:0032731 10.13 TNF IL17A IFNG CLEC7A
12 positive regulation of tumor necrosis factor production GO:0032760 10.13 IL17A IFNG FCGR3A CLEC7A CARD9
13 T cell activation GO:0042110 10.11 IL4 CLEC7A CD8A CD4
14 microglial cell activation GO:0001774 10.1 TNF IL4 IFNG
15 positive regulation of interleukin-6 production GO:0032755 10.1 CARD9 CLEC7A IFNG IL17A TNF
16 macrophage differentiation GO:0030225 10.09 IFNG CSF2 CD4
17 positive regulation of osteoclast differentiation GO:0045672 10.08 TNF IL17A IFNG
18 regulation of immune response GO:0050776 10.08 IL4 FCGR3B FCGR3A FCGR2A
19 positive regulation of nitric oxide biosynthetic process GO:0045429 10.06 TNF PTX3 IFNG CLEC7A
20 macrophage activation GO:0042116 10.05 IL4 FCGR3A CSF2
21 antifungal innate immune response GO:0061760 10.02 CARD9 CLEC6A CLEC7A
22 positive regulation of T-helper 17 type immune response GO:2000318 9.97 CARD9 CLEC6A CLEC7A
23 neuroinflammatory response GO:0150076 9.96 IL4 IFNG
24 positive regulation of killing of cells of another organism GO:0051712 9.96 IFNG CLEC7A
25 positive regulation of mononuclear cell migration GO:0071677 9.95 TNF IL4
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.93 TNF IFNG
27 positive regulation of nitrogen compound metabolic process GO:0051173 9.93 TNF IFNG
28 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.92 TNF IL17A CLEC7A CARD9
29 positive regulation of phagocytosis GO:0050766 9.91 TNF PTX3 MBL2 IFNG CLEC7A
30 detection of yeast GO:0001879 9.89 CLEC6A CLEC7A
31 positive regulation of vitamin D biosynthetic process GO:0060557 9.88 IFNG TNF
32 response to yeast GO:0001878 9.85 PTX3 CLEC7A CLEC6A
33 immune system process GO:0002376 9.85 CARD9 CD4 CD8A CLEC6A CLEC7A FCGR2A
34 immune response GO:0006955 9.62 TNF IL4 IL17A IFNG FCGR3B FCGR3A
35 positive regulation of interleukin-23 production GO:0032747 9.56 IL17A IFNG CSF2 CLEC7A

Molecular functions related to Cryptococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.85 TNF IL4 IL17A IFNG CSF2
2 (1->3)-beta-D-glucan binding GO:0001872 9.26 PTX3 CLEC7A
3 IgG binding GO:0019864 9.1 FCGR3B FCGR3A FCGR2A
Sources

Sources for Cryptococcosis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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