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MCID: CRY005
MIFTS: 54

Cryptococcosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cryptococcosis

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MalaCards integrated aliases for Cryptococcosis:

Name: Cryptococcosis 12 77 54 60 56 3 3 45 15 17
Infection by Cryptococcus Neoformans 74
Cryptococcus Neoformans Infection 12
Busse-Buschke's Disease 12
European Cryptococcosis 12
Cryptococcal Infection 12
Torulosis 12
Torula 12

Characteristics:

Orphanet epidemiological data:

60
cryptococcosis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12053
ICD9CM 36 117.5
MeSH 45 D003453
NCIt 51 C2967
SNOMED-CT 69 20850004 42386007
ICD10 34 B45 B45.9
MESH via Orphanet 46 D003453
ICD10 via Orphanet 35 B45.0 B45.1 B45.2 more
UMLS via Orphanet 75 C0010414
Orphanet 60 ORPHA1546
UMLS 74 C0010414
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Summaries for Cryptococcosis

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CDC : 3 Cryptococcus gattii is a fungus that lives in the environment in primarily tropical and sub-tropical areas of the world but also in some temperate regions such as British Columbia and some parts of the United States. C. gattii cryptococcosis is a rare infection that people can get after breathing in the microscopic fungus. The infection can affect the lungs, central nervous system, or both.

MalaCards based summary : Cryptococcosis, also known as infection by cryptococcus neoformans, is related to meningitis and aspergillosis. An important gene associated with Cryptococcosis is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Miconazole and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An opportunistic mycosis that results in fungal infection and has material basis in Cryptococcus neoformans or Cryptococcus gattii.

Wikipedia : 77 Cryptococcosis, also known as cryptococcal disease, is a potentially fatal fungal disease. It is caused... more...

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Related Diseases for Cryptococcosis

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Diseases related to Cryptococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.9 FCGR2A IFNG MBL2
2 aspergillosis 30.5 IFNG IL4 MBL2
3 coccidioidomycosis 30.4 CARD9 MBL2
4 pulmonary tuberculosis 30.1 IFNG IL4 MBL2
5 trichosporonosis 29.6 IFNG IL17A
6 candidiasis 29.6 CARD9 IFNG IL17A MBL2 PLB1
7 central nervous system vasculitis 29.5 IFNG IL17A
8 colitis 29.4 IFNG IL17A IL4
9 bronchiolitis 29.3 IFNG IL17A IL4
10 systemic lupus erythematosus 28.9 FCGR2A FCGR3A FCGR3B IFNG IL17A IL4
11 mycobacterium tuberculosis 1 28.9 IFNG IL17A IL4 MBL2
12 cryptococcal meningitis 11.5
13 acquired immunodeficiency syndrome 10.5
14 fixed drug eruption 10.4 IFNG SELL
15 transient neonatal neutropenia 10.4 FCGR3A FCGR3B
16 histoplasmosis 10.3
17 neisseria meningitidis infection 10.3 FCGR2A MBL2
18 adult lymphoma 10.3 FCGR2A FCGR3A
19 kawasaki disease 10.3 FCGR2A MBL2 SELL
20 cellulitis 10.3
21 campylobacteriosis 10.3 IFNG ST5
22 lung cancer 10.2
23 meningococcal meningitis 10.2 MBL2 ST5
24 human immunodeficiency virus infectious disease 10.2
25 lymphopenia 10.2
26 lymphoma 10.2
27 primary thrombocytopenia 10.2 FCGR2A FCGR3A
28 hyperlucent lung 10.2 IFNG IL4
29 b-cell growth factor 10.2 IFNG IL4
30 nickel allergic contact dermatitis 10.2 IFNG IL4
31 baylisascariasis 10.2 IFNG IL4
32 penicillin allergy 10.2 IFNG IL4
33 scleritis 10.2 IFNG IL4
34 arthritis 10.2
35 lupus erythematosus 10.2
36 molluscum contagiosum 10.2
37 atopic keratoconjunctivitis 10.2 IFNG IL4
38 crustacean allergy 10.2 IFNG IL4
39 toxic oil syndrome 10.1 IFNG IL4
40 leukemia 10.1
41 sarcoma 10.1
42 urinary schistosomiasis 10.1 IFNG IL4
43 tinea capitis 10.1 CARD9 ST5
44 vulvovaginal candidiasis 10.1 IL4 MBL2
45 rheumatoid arthritis 10.1
46 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.1
47 pneumonia 10.1
48 hyper ige syndrome 10.1 IFNG IL4
49 cardiac tamponade 10.1
50 pericarditis 10.1

Comorbidity relations with Cryptococcosis via Phenotypic Disease Network (PDN):


Acute Cystitis Cryptococcal Meningitis
Deficiency Anemia

Graphical network of the top 20 diseases related to Cryptococcosis:



Diseases related to Cryptococcosis
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Symptoms & Phenotypes for Cryptococcosis

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MGI Mouse Phenotypes related to Cryptococcosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CARD9 CLEC6A FCGR2A FCGR3B IFNG IL17A
2 immune system MP:0005387 9.28 CARD9 CLEC6A FCGR2A FCGR3B IFNG IL17A
Sources

Drugs & Therapeutics for Cryptococcosis

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Drugs for Cryptococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 22916-47-8 4189
2
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1397-89-3 5280965 14956
3
Fluconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 86386-73-4 3365
4
Voriconazole Approved, Investigational Phase 4,Phase 3 137234-62-9 71616
5
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 84625-61-6 55283
6
Lamivudine Approved, Investigational Phase 4,Not Applicable 134678-17-4 60825
7
Stavudine Approved, Investigational Phase 4,Not Applicable 3056-17-5 18283
8
Zidovudine Approved Phase 4 30516-87-1 35370
9
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
10
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
11
Nevirapine Approved Phase 4,Not Applicable 129618-40-2 4463
12
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
13
Tenofovir Approved, Experimental, Investigational Phase 4 147127-20-6 464205
14 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Liposomal amphotericin B Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Steroid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Cytochrome P-450 CYP2C19 Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Pharmaceutical Solutions Phase 4,Phase 3
28 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
29 Anti-Retroviral Agents Phase 4,Phase 3,Not Applicable
30 Antiviral Agents Phase 4,Phase 3,Phase 2,Not Applicable
31
Hydroxyitraconazole Phase 4,Phase 3,Phase 2,Not Applicable
32 Anti-HIV Agents Phase 4,Phase 3,Not Applicable
33 Reverse Transcriptase Inhibitors Phase 4,Not Applicable
34 Cytochrome P-450 CYP3A Inducers Phase 4,Not Applicable
35 Nucleic Acid Synthesis Inhibitors Phase 4,Not Applicable
36
protease inhibitors Phase 4,Phase 3,Phase 2
37 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
38 Atazanavir Sulfate Phase 4,Phase 3
39 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
40
Flucytosine Approved, Investigational Phase 2, Phase 3,Not Applicable 2022-85-7 3366
41
Posaconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 171228-49-2 147912
42
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
43
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
44
tannic acid Approved Phase 3 1401-55-4
45
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
46
Sertraline Approved Phase 3 79617-96-2 68617
47
Isavuconazole Approved, Investigational Phase 3 241479-67-4
48 Antimetabolites Phase 2, Phase 3,Not Applicable
49 Analgesics, Non-Narcotic Phase 3
50 Peripheral Nervous System Agents Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
2 Safety, Efficacy, and Pharmacokinetics of Amphotericin B Lipid Complex Completed NCT01656382 Phase 4 ABLC
3 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
4 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
5 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
6 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4 Itraconazole
7 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
8 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
9 Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis Unknown status NCT01125644 Phase 3 SPK-843
10 Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa Unknown status NCT01715922 Phase 2, Phase 3 Fluconazole;Flucytosine
11 Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Completed NCT00034658 Phase 3 Posaconazole
12 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
13 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3 Posaconazole oral suspension
14 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
15 Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS Completed NCT00001017 Phase 3 Fluconazole;Amphotericin B
16 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
17 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
18 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
19 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Completed NCT01802385 Phase 3 Sertraline
20 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
21 Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis Recruiting NCT03471988 Phase 3 AK1820;Voriconazole
22 Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Not yet recruiting NCT03945448 Phase 2, Phase 3 Single dose liposomal Amphotericin and Fluconazole;Fluconazole
23 Cryptococcal Antigen Screening Plus Sertraline Terminated NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
24 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2 Posaconazole oral suspension
25 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
26 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
27 Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis Completed NCT00145249 Phase 2 Amphotericin B;Fluconazole
28 Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis Completed NCT00012467 Phase 2 Itraconazole;Flucytosine;Fluconazole;Amphotericin B;Interferon gamma-1b
29 Treatment With Tamoxifen in Cryptococcal Meningitis Active, not recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
30 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00847678 Phase 2
31 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00324025 Phase 2 Mycograb;placebo
32 SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance Therapy Completed NCT00000677 Phase 1 SCH 39304
33 Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report Completed NCT02955862 Phase 1
34 The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis Completed NCT00002316 Phase 1 Lobradimil;Amphotericin B
35 Clinical Trial of Pulmonary Cryptococcosis in China Unknown status NCT02503449
36 Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis Unknown status NCT02136030 Not Applicable Liposomal amphotericin B;Amphotericin B-deoxycholate
37 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection Completed NCT00001701
38 Idiopathic CD4 Lymphocytopenia Completed NCT02113930
39 A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00000639 Not Applicable Itraconazole;Flucytosine;Fluconazole;Amphotericin B
40 A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients Completed NCT00002438 Not Applicable Itraconazole
41 Nevirapine Levels and Fluconazole Completed NCT00309582
42 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDS Completed NCT00002294 Not Applicable Fluconazole
43 Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00000708 Not Applicable Flucytosine;Fluconazole;Amphotericin B
44 A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis. Completed NCT00002113 Not Applicable Flucytosine;Fluconazole
45 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B Completed NCT00002306 Not Applicable Fluconazole
46 Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002076 Not Applicable Fluconazole
47 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome Completed NCT00002074 Not Applicable Fluconazole;Amphotericin B
48 Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00002019 Not Applicable Amphotericin B, Lipid-based;Amphotericin B
49 A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis Completed NCT00002305 Not Applicable Flucytosine;Fluconazole;Amphotericin B
50 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00002075 Not Applicable Flucytosine;Fluconazole;Amphotericin B

Search NIH Clinical Center for Cryptococcosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: cryptococcosis

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Genetic Tests for Cryptococcosis

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Anatomical Context for Cryptococcosis

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MalaCards organs/tissues related to Cryptococcosis:

42
Lung, Bone, Testes, Liver, Skin, T Cells, Brain
Sources

Publications for Cryptococcosis

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Articles related to Cryptococcosis:

(show top 50) (show all 1925)
# Title Authors Year
1
Disseminated Cryptococcosis with Bronchiolitis and Cellulitis. ( 30179584 )
2019
2
Pyoderma gangrenosum and primary cutaneous cryptococcosis in an ulcerative colitis patient. ( 29519678 )
2019
3
Cutaneous cryptococcosis. ( 29735406 )
2019
4
Meningeal cryptococcosis in a patient with angioimmunoblastic lymphoma treated with alemtuzumab. ( 30001898 )
2019
5
Cryptococcosis as a cause of organizing pneumonia. ( 31110941 )
2019
6
Sensitive bioluminescence imaging of fungal dissemination to the brain in mouse models of cryptococcosis. ( 31101657 )
2019
7
Mediastinal cryptococcosis simulating thyroid neoplasia in immunocompetent patient with prior diagnosis and treatment for COPD. ( 31080717 )
2019
8
Risk factors of laryngeal cryptococcosis: A case report. ( 31080714 )
2019
9
Cryptococcosis due to Cryptococcus gattii VGII in southeast Brazil: The One Health approach revealing a possible role for domestic cats. ( 31061785 )
2019
10
Probable Invasive Pulmonary Cryptococcosis and Possible Cryptococcal Empyema in CLL Treated With Frontline Ibrutinib. ( 31054610 )
2019
11
Prevalence of cryptococcosis in Atlántico, department of Colombia assessed with an active epidemiological search. ( 31038620 )
2019
12
An unusual presentation of Primary Cutaneous Cryptococcosis. ( 31012217 )
2019
13
Clonal Dispersal of Cryptococcus gattii VGII in an Endemic Region of Cryptococcosis in Colombia. ( 30991682 )
2019
14
First case report of cryptococcosis due to Cryptococcus decagattii in a pediatric patient in Argentina. ( 30942260 )
2019
15
Cryptococcosis in Solid Organ Transplantation- Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. ( 30900315 )
2019
16
Isolated Pulmonary Cryptococcosis Confused with Lung Tumor 5 Years After Kidney Transplantation: A Case Report. ( 30879590 )
2019
17
Idiopathic CD4 lymphopenia in a case of disseminated cryptococcosis with brain, vertebral spine and reproductive organ involvement. ( 30872296 )
2019
18
Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil. ( 30866766 )
2019
19
A Multicenter, Longitudinal Cohort Study of Cryptococcosis in HIV-Negative People in the United States. ( 30855688 )
2019
20
Gastric cryptococcosis: an unusual presentation of a common opportunistic disorder. ( 30785564 )
2019
21
A Case of Intramuscular Cryptococcosis Mimicking a Malignant Tumor on FDG PET/CT. ( 30762821 )
2019
22
Disseminated cryptococcosis with immunoglobulin G subclass deficiency. ( 30746859 )
2019
23
Drug development for cryptococcosis treatment: what can patents tell us? ( 30726342 )
2019
24
A Large Deep Skin Ulcer as an Initial Manifestation of Systemic Cryptococcosis. ( 30710325 )
2019
25
Disseminated Cryptococcosis After Liver Transplant: A Case Report. ( 30696395 )
2019
26
Clinical features and cause analysis of false positive results of Aspergillus galactomannan assay in pulmonary cryptococcosis patients. ( 30684164 )
2019
27
Laryngeal Cryptococcosis: An Evolving Rare Clinical Entity. ( 30678486 )
2019
28
Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome Is Associated With Dysregulation of IL-7/IL-7 Receptor Signaling Pathway in T Cells and Monocyte Activation. ( 30649031 )
2019
29
Disseminated Cryptococcosis in a Patient with Multiple Myeloma Treated with Daratumumab, Lenalidomide, and Dexamethasone. ( 30449801 )
2019
30
Epidemiological, Clinical and Outcome Aspects of Patients with Cryptococcosis Caused by Cryptococcus gattii from a Non-endemic Area of Brazil. ( 30415450 )
2019
31
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects. ( 30329097 )
2019
32
Cytological diagnosis of cryptococcosis in a biliary specimen: Report of a rare case with brief review of literature. ( 30153349 )
2019
33
Invasive fungal infection by Cryptococcus neoformans var. grubii with bone marrow and meningeal involvement in a HIV-infected patient: a case report. ( 30832607 )
2019
34
Pulmonary cryptococcosis coexisting with adenocarcinoma: a case report and review of the literature. ( 30384858 )
2018
35
A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models. ( 30057783 )
2018
36
Disseminated cryptococcosis presenting initially as lower limb cellulitis in a renal transplant recipient - a case report. ( 29374464 )
2018
37
Ulcerative cellulitis of the arm: a case of primary cutaneous cryptococcosis. ( 29630156 )
2018
38
Disseminated Cryptococcosis With Severe Increased Intracranial Pressure Complicated With Cranial Nerve Palsy in a Child. ( 29189676 )
2018
39
Disseminated cryptococcosis in Crohn's disease: a case report. ( 30514241 )
2018
40
Pulmonary cryptococcosis mimicking neoplasm in terms of uptake PET/CT. ( 29540949 )
2018
41
Diminished CD40L expression on T-cells in a case of disseminated cryptococcosis. ( 29567905 )
2018
42
Isolated iliac cryptococcosis in an immunocompetent patient. ( 29596420 )
2018
43
The status of cryptococcosis in Latin America. ( 29641639 )
2018
44
Additive potential of combination therapy against cryptococcosis employing a novel amphotericin B and fluconazole loaded dual delivery system. ( 29653177 )
2018
45
Neglected disease, neglected populations: the fight against Cryptococcus and cryptococcosis. ( 29668824 )
2018
46
Variability in innate host immune responses to cryptococcosis. ( 29668826 )
2018
47
Outcomes of cryptococcosis in renal transplant recipients in a less-resourced health care system. ( 29677399 )
2018
48
Cryptococcosis with bird's eye manifestation: A case report. ( 29697086 )
2018
49
Treatment of cryptococcosis in non-HIV immunocompromised patients. ( 29738314 )
2018
50
Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis. ( 29740519 )
2018
Sources

Variations for Cryptococcosis

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Expression for Cryptococcosis

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Search GEO for disease gene expression data for Cryptococcosis.
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Pathways for Cryptococcosis

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Pathways related to Cryptococcosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.77 CARD9 CLEC6A FCGR2A FCGR3A FCGR3B IFNG
2
NF-kappaB Signaling 4
12.34 CARD9 IFNG IL17A IL4
3
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.29 FCGR3A FCGR3B IFNG IL4
4
Toxoplasmosis 38
Show member pathways
 11.99 FCGR2A FCGR3A FCGR3B IFNG IL4
5
Phagosome 38
11.94 FCGR2A FCGR3A FCGR3B MBL2
6
Tuberculosis 38
11.91 CARD9 FCGR2A FCGR3A FCGR3B IFNG
7
Osteoclast differentiation 38
11.81 FCGR2A FCGR3A FCGR3B IFNG
8
Spinal Cord Injury 1
11.79 FCGR2A IFNG IL4
9
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.73 FCGR2A IFNG IL4 SELL
10
Innate Lymphoid Cell Differentiation Pathways 66
11.57 IFNG IL17A IL4
11
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.45 FCGR2A FCGR3A FCGR3B IFNG IL4
12
Staphylococcus aureus infection 38
11.29 FCGR2A FCGR3A FCGR3B MBL2
13
Development and heterogeneity of the ILC family 1
11.11 IFNG IL17A IL4
14
Cytokines and Inflammatory Response 1
11.02 IFNG IL4
15
OX40 Pathway 65
10.96 IFNG IL4
16
Microglia Activation During Neuroinflammation: Microglia Polarization 66
10.95 FCGR2A FCGR3A FCGR3B IFNG IL17A IL4
Sources

GO Terms for Cryptococcosis

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Cellular components related to Cryptococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 8.8 FCGR2A FCGR3B SELL

Biological processes related to Cryptococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.56 CGB3 IFNG IL17A IL4
2 immune response GO:0006955 9.35 FCGR3A FCGR3B IFNG IL17A IL4
3 defense response to fungus GO:0050832 9.32 CLEC6A IL17A
4 positive regulation of osteoclast differentiation GO:0045672 9.16 IFNG IL17A
5 positive regulation of interleukin-23 production GO:0032747 8.62 IFNG IL17A

Molecular functions related to Cryptococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mannose binding GO:0005537 8.96 CLEC6A MBL2
2 IgG binding GO:0019864 8.8 FCGR2A FCGR3A FCGR3B
Sources

Sources for Cryptococcosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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