Cryptococcosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRY005 MIFTS: 53	Cryptococcosis Categories: Infectious diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Cryptococcosis

MalaCards integrated aliases for Cryptococcosis:

Name: Cryptococcosis ¹² ⁷⁶ ⁵³ ⁵⁹ ⁵⁵ ³ ³ ⁴⁴ ¹⁵

Infection by Cryptococcus Neoformans ⁷³

Cryptococcus Neoformans Infection ¹²

Busse-Buschke's Disease ¹²

European Cryptococcosis ¹²

Cryptococcal Infection ¹²

Torulosis ¹²

Torula ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁹

cryptococcosis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Certain infectious and parasitic diseases

Mycoses

Cryptococcosis

Cerebral cryptococcosis

Cryptococcosis, unspecified

Cutaneous cryptococcosis

Disseminated cryptococcosis

Osseous cryptococcosis

Other forms of cryptococcosis

Pulmonary cryptococcosis

Orphanet: ⁵⁹

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:12053

ICD10 ³³ B45 B45.9

ICD9CM ³⁵ 117.5

MeSH ⁴⁴ D003453

NCIt ⁵⁰ C2967

SNOMED-CT ⁶⁸ 20850004 42386007

Orphanet ⁵⁹ ORPHA1546

UMLS via Orphanet ⁷⁴ C0010414

ICD10 via Orphanet ³⁴ B45.1 B45.2 B45.3 more

MESH via Orphanet ⁴⁵ D003453

UMLS ⁷³ C0010414

Sources

Summaries for Cryptococcosis

CDC : ³ Cryptococcus gattii is a fungus that lives in the environment in primarily tropical and sub-tropical areas of the world but also in some temperate regions such as British Columbia and some parts of the United States. C. gattii cryptococcosis is a rare infection that people can get after breathing in the microscopic fungus. The infection can affect the lungs, central nervous system, or both.

MalaCards based summary : Cryptococcosis, also known as infection by cryptococcus neoformans, is related to cryptococcal meningitis and meningitis. An important gene associated with Cryptococcosis is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and skin, and related phenotypes are hematopoietic system and immune system

Disease Ontology : ¹² An opportunistic mycosis that results in fungal infection and has material basis in Cryptococcus neoformans or Cryptococcus gattii.

Wikipedia : ⁷⁶ Cryptococcosis, also known as cryptococcal disease, is a potentially fatal fungal disease. It is caused... more...

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Related Diseases for Cryptococcosis

Diseases related to Cryptococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)

#	Related Disease	Score	Top Affiliating Genes
1	cryptococcal meningitis	32.2	IFNG MBL2
2	meningitis	30.4	FCGR2A IFNG MBL2 TLR9
3	aspergillosis	30.1	IFNG IL4 MBL2 TLR9
4	coccidioidomycosis	30.0	CARD9 MBL2
5	candidiasis	29.9	CARD9 IFNG MBL2 PLB1
6	viral infectious disease	29.9	IFNG IL4 TLR9
7	colitis	29.8	IFNG IL4 TLR9
8	toxoplasmosis	29.8	IFNG IL4 TLR9
9	bronchiolitis	29.8	IFNG IL4 TLR9
10	central nervous system vasculitis	29.7	IFNG TLR9
11	invasive aspergillosis	29.7	IFNG MBL2 TLR9
12	pulmonary tuberculosis	29.6	IFNG IL4 MBL2 TLR9
13	lymphopenia	29.6	IFNG SELL UNC119
14	systemic lupus erythematosus	29.4	FCGR2A FCGR3A FCGR3B IFNG IL4 MBL2
15	mycobacterium tuberculosis 1	29.4	IFNG IL4 MBL2 TLR9
16	leishmaniasis	29.4	FCGR2A IFNG IL4 TLR9
17	acquired immunodeficiency syndrome	10.3
18	fixed drug eruption	10.3	IFNG SELL
19	lung cancer	10.2
20	transient neonatal neutropenia	10.2	FCGR3A FCGR3B
21	adult dermatomyositis	10.2	MBL2 TLR9
22	human immunodeficiency virus infectious disease	10.2
23	myositis fibrosa	10.2	IFNG TLR9
24	cellulitis	10.2
25	hyperlucent lung	10.2	IFNG IL4
26	adult lymphoma	10.2	FCGR2A FCGR3A
27	autoimmune myocarditis	10.2	IFNG IL4
28	kawasaki disease	10.2	FCGR2A MBL2 SELL
29	neisseria meningitidis infection	10.2	FCGR2A MBL2
30	lymphoma	10.2
31	molluscum contagiosum	10.2
32	b-cell growth factor	10.2	IFNG IL4
33	nickel allergic contact dermatitis	10.1	IFNG IL4
34	baylisascariasis	10.1	IFNG IL4
35	penicillin allergy	10.1	IFNG IL4
36	scleritis	10.1	IFNG IL4
37	atopic keratoconjunctivitis	10.1	IFNG IL4
38	crustacean allergy	10.1	IFNG IL4
39	arthritis	10.1
40	plasmodium falciparum malaria	10.1	FCGR2A IFNG TLR9
41	fungal meningitis	10.1	IFNG UNC119
42	toxic oil syndrome	10.1	IFNG IL4
43	urinary schistosomiasis	10.1	IFNG IL4
44	campylobacteriosis	10.1	IFNG ST5
45	vulvovaginal candidiasis	10.1	IL4 MBL2
46	skin conditions	10.1
47	chronic intestinal failure	10.1
48	hypersplenism	10.1	IFNG IL4
49	filarial elephantiasis	10.1	IL4 TLR9
50	hyper ige syndrome	10.1	IFNG IL4

Comorbidity relations with Cryptococcosis via Phenotypic Disease Network (PDN):

Acute Cystitis	Cryptococcal Meningitis
Deficiency Anemia

Graphical network of the top 20 diseases related to Cryptococcosis:

Sources

Symptoms & Phenotypes for Cryptococcosis

MGI Mouse Phenotypes related to Cryptococcosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.56	CARD9 FCGR2A FCGR3B IFNG IL4 MBL2
2	immune system	MP:0005387	9.23	CARD9 FCGR2A FCGR3B IFNG IL4 MBL2

Sources

Drugs & Therapeutics for Cryptococcosis

Drugs for Cryptococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Amphotericin B

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

1397-89-3

5280965 14956

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

22916-47-8

4189

Fluconazole

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

86386-73-4

3365

Voriconazole

Approved, Investigational

Phase 4,Phase 3

137234-62-9

71616

Itraconazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

84625-61-6

55283

Lamivudine

Approved, Investigational

Phase 4,Not Applicable

134678-17-4

60825

Zidovudine

Approved

Phase 4

30516-87-1

35370

Efavirenz

Approved, Investigational

Phase 4

154598-52-4

64139

Stavudine

Approved, Investigational

Phase 4,Not Applicable

3056-17-5

18283

Ritonavir

Approved, Investigational

Phase 4,Phase 3

155213-67-5

392622

Emtricitabine

Approved, Investigational

Phase 4

143491-57-0

60877

Nevirapine

Approved

Phase 4,Not Applicable

129618-40-2

4463

Tenofovir

Experimental, Investigational

Phase 4

147127-20-6

464205

Anti-Infective Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Liposomal amphotericin B

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Antiparasitic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antiprotozoal Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Antifungal Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Steroid Synthesis Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Cytochrome P-450 CYP2C19 Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Hormones

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Cytochrome P-450 CYP2C9 Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Pharmaceutical Solutions

Phase 4,Phase 3

Cytochrome P-450 CYP3A Inhibitors

Phase 4,Phase 3,Phase 2,Not Applicable

Hydroxyitraconazole

Phase 4,Phase 3,Phase 2,Not Applicable

Reverse Transcriptase Inhibitors

Phase 4,Not Applicable

Anti-HIV Agents

Phase 4,Phase 3,Not Applicable

Antiviral Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Nucleic Acid Synthesis Inhibitors

Phase 4,Not Applicable

Anti-Retroviral Agents

Phase 4,Phase 3,Not Applicable

Cytochrome P-450 CYP3A Inducers

Phase 4,Not Applicable

HIV Protease Inhibitors

Phase 4,Phase 3,Phase 2

Atazanavir Sulfate

Phase 4,Phase 3

protease inhibitors

Phase 4,Phase 3,Phase 2

Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

Phase 4

Flucytosine

Approved, Investigational

Phase 2, Phase 3,Not Applicable

2022-85-7

3366

Posaconazole

Approved, Investigational, Vet_approved

Phase 3,Phase 2

171228-49-2

147912

Clotrimazole

Approved, Vet_approved

Phase 3

23593-75-1

2812

Aldesleukin

Approved

Phase 3

85898-30-2, 110942-02-4

tannic acid

Approved

Phase 3

Benzocaine

Approved, Investigational

Phase 3

94-09-7, 1994-09-7

2337

Sertraline

Approved

Phase 3

79617-96-2

68617

Antimetabolites

Phase 2, Phase 3,Not Applicable

Peripheral Nervous System Agents

Phase 3,Phase 2

Analgesics

Phase 3

Interleukin-2

Phase 3

Interventional clinical trials:

(show top 50) (show all 64)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis	Unknown status	NCT02686853	Phase 4	Liposomal amphotericin B
2	Safety, Efficacy, and Pharmacokinetics of Amphotericin B Lipid Complex	Completed	NCT01656382	Phase 4	ABLC
3	Operational Research for Cryptococcal Antigen Screening	Completed	NCT01535469	Phase 4	Fluconazole
4	A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections	Completed	NCT00647907	Phase 4	Voriconazole
5	Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis	Completed	NCT00976040	Phase 4
6	Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection	Completed	NCT01198236	Phase 4	Itraconazole
7	Cryptococcal Optimal ART Timing Trial	Completed	NCT01075152	Phase 4	efavirenz
8	Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT)	Completed	NCT00552240	Phase 4	tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
9	Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis	Unknown status	NCT01125644	Phase 3	SPK-843
10	Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa	Unknown status	NCT01715922	Phase 2, Phase 3	Fluconazole;Flucytosine
11	Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041)	Completed	NCT00034658	Phase 3	Posaconazole
12	Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)	Completed	NCT00000676	Phase 3	Clotrimazole;Fluconazole
13	Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095)	Completed	NCT00034632	Phase 3	Posaconazole oral suspension
14	A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection	Completed	NCT00784368	Phase 3	ITCZ Oral Solution;ITCZ-IV
15	Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS	Completed	NCT00001017	Phase 3	Fluconazole;Amphotericin B
16	PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV)	Completed	NCT01099579	Phase 3	Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
17	Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study)	Completed	NCT00013611	Phase 3	Proleukin
18	An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy	Completed	NCT00004978	Phase 3	Recombinant interleukin-2 (rIL-2)
19	Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis	Completed	NCT01802385	Phase 3	Sertraline
20	Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC	Completed	NCT01589289	Phase 3
21	Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis	Recruiting	NCT03471988	Phase 3	AK1820;Voriconazole
22	Cryptococcal Antigen Screening Plus Sertraline	Terminated	NCT03002012	Phase 3	Sertraline;Placebo Oral Tablet;Fluconazole
23	PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)	Completed	NCT00034671	Phase 2	Posaconazole oral suspension
24	High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals	Completed	NCT00885703	Phase 1, Phase 2	Fluconazole;Amphotericin B
25	Dexamethasone in Cryptococcal Meningitis	Completed	NCT00000776	Phase 2	Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
26	Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis	Completed	NCT00145249	Phase 2	Amphotericin B;Fluconazole
27	Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis	Completed	NCT00012467	Phase 2	Itraconazole;Flucytosine;Fluconazole;Amphotericin B;Interferon gamma-1b
28	Treatment With Tamoxifen in Cryptococcal Meningitis	Recruiting	NCT03112031	Phase 2	Tamoxifen;Amphotericin B;Fluconazole
29	Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS	Terminated	NCT00847678	Phase 2
30	Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS	Terminated	NCT00324025	Phase 2	Mycograb;placebo
31	SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance Therapy	Completed	NCT00000677	Phase 1	SCH 39304
32	Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report	Completed	NCT02955862	Phase 1
33	The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis	Completed	NCT00002316	Phase 1	Lobradimil;Amphotericin B
34	Clinical Trial of Pulmonary Cryptococcosis in China	Unknown status	NCT02503449
35	Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis	Unknown status	NCT02136030	Not Applicable	Liposomal amphotericin B;Amphotericin B-deoxycholate
36	Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection	Completed	NCT00001701
37	Idiopathic CD4 Lymphocytopenia	Completed	NCT02113930
38	A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis	Completed	NCT00000639	Not Applicable	Itraconazole;Flucytosine;Fluconazole;Amphotericin B
39	A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients	Completed	NCT00002438	Not Applicable	Itraconazole
40	Nevirapine Levels and Fluconazole	Completed	NCT00309582
41	A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDS	Completed	NCT00002294	Not Applicable	Fluconazole
42	Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis	Completed	NCT00000708	Not Applicable	Flucytosine;Fluconazole;Amphotericin B
43	A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.	Completed	NCT00002113	Not Applicable	Flucytosine;Fluconazole
44	A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B	Completed	NCT00002306	Not Applicable	Fluconazole
45	Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis	Completed	NCT00002076	Not Applicable	Fluconazole
46	Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome	Completed	NCT00002074	Not Applicable	Fluconazole;Amphotericin B
47	Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome	Completed	NCT00002019	Not Applicable	Amphotericin B, Lipid-based;Amphotericin B
48	A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis	Completed	NCT00002305	Not Applicable	Flucytosine;Fluconazole;Amphotericin B
49	Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis	Completed	NCT00002075	Not Applicable	Flucytosine;Fluconazole;Amphotericin B
50	A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis	Completed	NCT00002068	Not Applicable	Fluconazole;Amphotericin B

Search NIH Clinical Center for Cryptococcosis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

itraconazole

Cochrane evidence based reviews: cryptococcosis

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Genetic Tests for Cryptococcosis

Sources

Anatomical Context for Cryptococcosis

MalaCards organs/tissues related to Cryptococcosis:

⁴¹

Lung, Liver, Skin, T Cells, Heart, Bone, B Cells

Sources

Publications for Cryptococcosis

Articles related to Cryptococcosis:

(show top 50) (show all 1063)

#	Title	Authors	Year
1	Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis. ( 29740519 )	Truong M....Charles I.G.	2018
2	The status of cryptococcosis in Latin America. ( 29641639 )	Firacative C....CastaA+eda E.	2018
3	Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome. ( 29742199 )	Chammard T.B....Alanio A.	2018
4	Disseminated cryptococcosis in HIV negative patient. ( 29754135 )	Hassoun A....Mehrotra N.	2018
5	Additive potential of combination therapy against cryptococcosis employing a novel amphotericin B and fluconazole loaded dual delivery system. ( 29653177 )	Khan A.A....Malik A.	2018
6	Outcomes of cryptococcosis in renal transplant recipients in a less-resourced health care system. ( 29677399 )	Ponzio V....Colombo A.L.	2018
7	Miliary tuberculosis with co-existing pulmonary cryptococcosis in non-HIV patient without underlying diseases: a case report. ( 29338706 )	Sawai T....Mukae H.	2018
8	Tuberculous peritonitis and pleurisy accompanied by pulmonary cryptococcosis: A case report. ( 29756504 )	Chen J.K....Li J.Q.	2018
9	Variability in innate host immune responses to cryptococcosis. ( 29668826 )	Garelnabi M....May R.C.	2018
10	Multifocal Soft Tissue Cryptococcosis in a Renal Transplant Recipient: The Importance of Suspecting Atypical Pathogens in the Immunocompromised Host. ( 29957160 )	Ajmal S....Wilhelm M.	2018
11	Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis. ( 29354657 )	Rohatgi S....Pirofski L.A.	2018
12	Pulmonary cryptococcosis mimicking neoplasm in terms of uptake PET/CT. ( 29540949 )	de Farias L.P.G....de Miranda C.M.N.R.	2018
13	Neglected disease, neglected populations: the fight against Cryptococcus and cryptococcosis. ( 29668824 )	Rodrigues M.L.	2018
14	Disseminated cryptococcosis presenting initially as lower limb cellulitis in a renal transplant recipient - a case report. ( 29374464 )	Chakradeo K....De Silva J.	2018
15	Isolated iliac cryptococcosis in an immunocompetent patient. ( 29596420 )		2018
16	Treatment of cryptococcosis in non-HIV immunocompromised patients. ( 29738314 )		2018
17	Cutaneous cryptococcosis. ( 29735406 )		2018
18	Cryptococcosis with bird's eye manifestation: A case report. ( 29697086 )		2018
19	Diminished CD40L expression on T-cells in a case of disseminated cryptococcosis. ( 29567905 )		2018
20	Clinical features and radiological characteristics of pulmonary cryptococcosis. ( 29848126 )		2018
21	Epidemiological trends of cryptococcosis in Italy: Molecular typing and susceptibility pattern of Cryptococcus neoformans isolates collected during a 20-year period. ( 29373716 )		2018
22	Ulcerative cellulitis of the arm: a case of primary cutaneous cryptococcosis. ( 29630156 )		2018
23	Duodenum Cryptococcosis Mimicking Primary Duodenum Cancer on PET/CT Imaging. ( 29538024 )		2018
24	Cryptococcosis as a cause of nephrotic syndrome? A case report and review of the literature. ( 29942774 )		2018
25	Cutaneous Cryptococcosis Mimicking Leishmaniasis. ( 29342402 )		2018
26	Disseminated cryptococcosis associated with administration of eculizumab. ( 29895518 )		2018
27	Pulmonary cryptococcosis coexisting with adenocarcinoma: a case report and review of the literature. ( 30384858 )	Li L...Shao C	2018
28	Disseminated Cryptococcosis with Bronchiolitis and Cellulitis. ( 30179584 )	Abe N...Atsumi T	2018
29	A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models. ( 30057783 )	S? NP...Johann S	2018
30	Central Nervous System Vasculitis for Cryptococcosis in an Immunocompetent Patient. ( 30200288 )	Zimelewicz Oberman D...Cuello Oderiz C	2018
31	Disseminated cryptococcosis in Crohn's disease: a case report. ( 30514241 )	Chavapradit N...Angkasekwinai N	2018
32	Examination of cryptococcal glucuronoxylomannan antigen in bronchoalveolar lavage fluid for diagnosing pulmonary cryptococcosis in HIV-negative patients. ( 28419364 )	Oshima K...Izumikawa K	2018
33	Systemic cryptococcosis in an immune-competent child. ( 28965793 )	Saini AG...Singhi P	2018
34	Epidemiology and trends of cryptococcosis in the United States from 2000 to 2007: A population-based study. ( 28971712 )	Shaheen AA...Mody CH	2018
35	A new method for studying cryptococcosis in a murine model using 99mTc-Cryptococcus gattii. ( 28992125 )	Costa MC...Santos DA	2018
36	Disseminated cryptococcosis in a patient taking tocilizumab for Castleman's disease. ( 29021093 )	Nishioka H...Kamei H	2018
37	Disseminated Cryptococcosis with Marked Eosinophilia in a Postpartum Woman. ( 29021482 )	Yokoyama T...Iwanaga T	2018
38	Comparative Epidemiology and Outcomes of Human Immunodeficiency virus (HIV), Non-HIV Non-transplant, and Solid Organ Transplant Associated Cryptococcosis: A Population-Based Study. ( 29028978 )	George IA...Santos CAQ	2018
39	Pulmonary cryptococcosis diagnosed on a lung fine-needle aspiration. ( 29063707 )	Lu J...Salih ZT	2018
40	Potassium iodide: A forgotten remedy for cutaneous cryptococcosis. ( 29124847 )	Bhattacharjee R...Narang T	2018
41	Cryptococcosis in an Infectious Diseases Hospital of Buenos Aires, Argentina. Revision of 2041 cases: Diagnosis, clinical features and therapeutics. ( 29129578 )	Arechavala A...Santiso G	2018
42	Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections. ( 29144957 )	Schiave LA...Martinez R	2018
43	Cryptococcosis manifesting as isolated biliary infection: Case report and brief review of literature. ( 29150356 )	Zhou HY...Li DM	2018
44	Kinsbourne syndrome associated with cryptococcosis infection. ( 29174170 )	Cavalcante-Filho JRM...Ribeiro EML	2018
45	Disseminated Cryptococcosis Presenting as Miliary Lung Shadows in an Immunocompetent Child. ( 29177510 )	Ismail J...Lodha R	2018
46	Brainstem dysfunction heralding disseminated cryptococcosis. ( 29454181 )	Srivanitchapoom P...Sathornsumetee S	2018
47	Antifungal activity of Annona coriacea Mart. ethanol extracts against the aetiological agents of cryptococcosis. ( 29463129 )	Almeida-Apolonio AA...Chang MR	2018
48	Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance. ( 29494502 )	Escand?n P...Casta?eda E	2018
49	The war on cryptococcosis: A Review of the antifungal arsenal. ( 29513785 )	Mourad A...Perfect JR	2018
50	Pyoderma gangrenosum and primary cutaneous cryptococcosis in an ulcerative colitis patient. ( 29519678 )	Fraile L?pez M...Riestra S	2018

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Genes for Cryptococcosis

Genes related to Cryptococcosis (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SELL	Selectin L	Protein Coding	23.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15776384
2	IFNG	Interferon Gamma	Protein Coding	22.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MBL2	Mannose Binding Lectin 2	Protein Coding	20.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	FCGR2A	Fc Fragment Of IgG Receptor IIa	Protein Coding	19.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	FCGR3B	Fc Fragment Of IgG Receptor IIIb	Protein Coding	19.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TLR9	Toll Like Receptor 9	Protein Coding	18.73	DISEASES inferred ¹⁵ ¹⁵
7	FCGR3A	Fc Fragment Of IgG Receptor IIIa	Protein Coding	16.68	GeneCards inferred via : Publications (show sections)
8	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	16.34	DISEASES inferred ¹⁵
9	ZHX2	Zinc Fingers And Homeoboxes 2	Protein Coding	16.2	DISEASES inferred ¹⁵
10	PLB1	Phospholipase B1	Protein Coding	16.07	DISEASES inferred ¹⁵
11	UNC119	Unc-119 Lipid Binding Chaperone	Protein Coding	15.8	DISEASES inferred ¹⁵
12	ST5	Suppression Of Tumorigenicity 5	Protein Coding	15.53	DISEASES inferred ¹⁵
13	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	15.46	DISEASES inferred ¹⁵
14	IL4	Interleukin 4	Protein Coding	15.23	DISEASES inferred ¹⁵

Sources

Variations for Cryptococcosis

Sources

Expression for Cryptococcosis

Search GEO for disease gene expression data for Cryptococcosis.

Sources

Pathways for Cryptococcosis

Pathways related to Cryptococcosis according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.78	CARD9 FCGR2A FCGR3A FCGR3B IFNG IL4
2	NF-kappaB Signaling ⁴	12.33	CARD9 IFNG IL4 TLR9
3	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.27	FCGR3A FCGR3B IFNG IL4
4	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	11.99	FCGR2A FCGR3A FCGR3B IFNG IL4
5	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	11.94	IFNG IL4 TLR9
6	Phagosome ³⁷	11.92	FCGR2A FCGR3A FCGR3B MBL2
7	Osteoclast differentiation ³⁷	11.81	FCGR2A FCGR3A FCGR3B IFNG
8	Spinal Cord Injury ¹	11.78	FCGR2A IFNG IL4
9	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.73	FCGR2A IFNG IL4 SELL
10	Tuberculosis ³⁷	11.69	CARD9 FCGR2A FCGR3A FCGR3B IFNG TLR9
11	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	11.65	FCGR2A FCGR3A FCGR3B IFNG IL4
12	Phagocytosis of Microbes ⁶⁴	11.58	FCGR2A FCGR3B TLR9
13	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.5	IFNG SELL TLR9
14	Staphylococcus aureus infection ³⁷	11.31	FCGR2A FCGR3A FCGR3B MBL2
15	Inflammatory Response Pathway ¹	11.1	IFNG IL4
16	Development and heterogeneity of the ILC family ¹	11.08	IFNG IL4
17	Cytokines and Inflammatory Response ¹	11.03	IFNG IL4
18	OX40 Pathway ⁶⁴	10.97	IFNG IL4
19	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	10.87	FCGR2A FCGR3A FCGR3B IFNG IL4

Sources

GO Terms for Cryptococcosis

Cellular components related to Cryptococcosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule membrane	GO:0030667	8.8	FCGR2A FCGR3B SELL

Biological processes related to Cryptococcosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to virus	GO:0051607	9.33	CARD9 IFNG TLR9
2	immune response	GO:0006955	9.02	FCGR3A FCGR3B IFNG IL4 TLR9
3	positive regulation of interleukin-12 production	GO:0032735	8.96	IFNG TLR9

Molecular functions related to Cryptococcosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	IgG binding	GO:0019864	8.8	FCGR2A FCGR3A FCGR3B

Sources

Sources for Cryptococcosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Cryptococcosis

Aliases & Classifications for Cryptococcosis

MalaCards integrated aliases for Cryptococcosis:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Cryptococcosis

Related Diseases for Cryptococcosis

Diseases related to Cryptococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Cryptococcosis via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Cryptococcosis:

Symptoms & Phenotypes for Cryptococcosis

MGI Mouse Phenotypes related to Cryptococcosis:

Drugs & Therapeutics for Cryptococcosis

Drugs for Cryptococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: cryptococcosis

Genetic Tests for Cryptococcosis

Anatomical Context for Cryptococcosis

MalaCards organs/tissues related to Cryptococcosis:

Publications for Cryptococcosis

Articles related to Cryptococcosis:

Genes for Cryptococcosis

Genes related to Cryptococcosis (0 elite genes):

Variations for Cryptococcosis

Expression for Cryptococcosis

Pathways for Cryptococcosis

Pathways related to Cryptococcosis according to GeneCards Suite gene sharing:

GO Terms for Cryptococcosis

Cellular components related to Cryptococcosis according to GeneCards Suite gene sharing:

Biological processes related to Cryptococcosis according to GeneCards Suite gene sharing:

Molecular functions related to Cryptococcosis according to GeneCards Suite gene sharing:

Sources for Cryptococcosis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :