Aliases & Classifications for Cryptogenic Cirrhosis

MalaCards integrated aliases for Cryptogenic Cirrhosis:

Name: Cryptogenic Cirrhosis 26
Cirrhosis, Cryptogenic 26 30 13 6 41 74

External Ids:

UMLS 74 C0267809

Summaries for Cryptogenic Cirrhosis

Genetics Home Reference : 26 Cryptogenic cirrhosis is a condition that impairs liver function. People with this condition develop irreversible liver disease caused by scarring of the liver (cirrhosis), typically in mid- to late adulthood.

MalaCards based summary : Cryptogenic Cirrhosis, also known as cirrhosis, cryptogenic, is related to liver cirrhosis and hepatitis. An important gene associated with Cryptogenic Cirrhosis is KRT18 (Keratin 18), and among its related pathways/superpathways are Selenium Micronutrient Network and Formation of Fibrin Clot (Clotting Cascade). The drugs Liver Extracts and Hormones, Hormone Substitutes, and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and breast, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Cryptogenic Cirrhosis

Diseases related to Cryptogenic Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 liver cirrhosis 32.0 F2 HFE KRT18 KRT8
2 hepatitis 30.6 F2 KRT18 KRT8
3 nonalcoholic steatohepatitis 30.2 F2 HFE KRT18
4 liver disease 30.0 F2 HFE KRT18 KRT8
5 acute liver failure 29.6 F2 F5
6 hepatocellular carcinoma 10.3
7 fatty liver disease 10.3
8 neurenteric cyst 10.3 KRT18 KRT8
9 proliferating trichilemmal cyst 10.3 KRT18 KRT8
10 cutaneous adenocystic carcinoma 10.3 KRT18 KRT8
11 nonalcoholic fatty liver disease 10.3
12 hepatitis c 10.3
13 cervical clear cell adenocarcinoma 10.3 KRT18 KRT8
14 odontoma 10.3 KRT18 KRT8
15 mucinous tubular and spindle renal cell carcinoma 10.3 KRT18 KRT8
16 papillary ependymoma 10.3 KRT18 KRT8
17 lymphoepithelioma-like carcinoma 10.3 KRT18 KRT8
18 intraneural perineurioma 10.3 KRT18 KRT8
19 nephrogenic adenofibroma 10.3 KRT18 KRT8
20 hepatitis b 10.2
21 primary cutaneous amyloidosis 10.2 KRT18 KRT8
22 hepatitis c virus 10.2
23 sweat gland cancer 10.2 KRT18 KRT8
24 oncocytoma 10.2 KRT18 KRT8
25 chromophobe renal cell carcinoma 10.2 KRT18 KRT8
26 ameloblastoma 10.1 KRT18 KRT8
27 sticky platelet syndrome 10.1 F5 SERPINE1
28 quebec platelet disorder 10.1 F5 SERPINE1
29 meningococcemia 10.1 F5 SERPINE1
30 factor xiii deficiency 10.1 F5 SERPINE1
31 legg-calve-perthes disease 10.1 F5 SERPINE1
32 cervical intraepithelial neoplasia 10.1 KRT8 MTHFR
33 neonatal stroke 10.1 MTHFR SERPINE1
34 celiac disease 1 10.0
35 alpha-1-antitrypsin deficiency 10.0
36 portal hypertension 10.0
37 hepatitis e 10.0
38 hepatopulmonary syndrome 10.0
39 gastroschisis 10.0 F5 MTHFR
40 lemierre's syndrome 10.0 MTHFR SERPINE1
41 intracranial thrombosis 10.0 F5 MTHFR
42 schizencephaly 10.0 F5 MTHFR
43 paracetamol poisoning 9.9 F2 F5
44 cerebral sinovenous thrombosis 9.9 F2 F5
45 cholecystitis 9.9 F2 KRT18
46 hemoglobin e disease 9.9 F2 F5
47 placenta disease 9.9 F5 MTHFR
48 prothrombin deficiency, congenital 9.9 F2 F5
49 sagittal sinus thrombosis 9.9 F2 F5
50 blue toe syndrome 9.9 F2 SERPINE1

Graphical network of the top 20 diseases related to Cryptogenic Cirrhosis:



Diseases related to Cryptogenic Cirrhosis

Symptoms & Phenotypes for Cryptogenic Cirrhosis

MGI Mouse Phenotypes related to Cryptogenic Cirrhosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.92 F2 F5 HFE KRT18 KRT8 LIPA
2 homeostasis/metabolism MP:0005376 9.8 F2 F5 HFE KRT8 LIPA MTHFR
3 integument MP:0010771 9.55 F2 F5 LIPA MTHFR SERPINE1
4 liver/biliary system MP:0005370 9.5 F5 HFE KRT18 KRT8 LIPA MTHFR
5 mortality/aging MP:0010768 9.23 F2 F5 HFE KRT18 KRT8 LIPA

Drugs & Therapeutics for Cryptogenic Cirrhosis

Drugs for Cryptogenic Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Phase 2, Phase 3,Phase 3
2 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
3 Sitagliptin Phosphate Phase 2
4 Hormones Phase 2
5 Dipeptidyl-Peptidase IV Inhibitors Phase 2
6 HIV Protease Inhibitors Phase 2
7 Incretins Phase 2
8 Hypoglycemic Agents Phase 2,Not Applicable
9 Hormone Antagonists Phase 2
10
protease inhibitors Phase 2
11
Pentoxifylline Approved, Investigational Not Applicable 6493-05-6 4740
12
Zinc Approved, Investigational Not Applicable 7440-66-6 32051
13
Metformin Approved Not Applicable 657-24-9 14219 4091
14
Methionine Approved, Nutraceutical Not Applicable 63-68-3 6137
15 Phosphodiesterase Inhibitors Not Applicable
16 Free Radical Scavengers Not Applicable
17 Radiation-Protective Agents Not Applicable
18 Protective Agents Not Applicable
19 Vasodilator Agents Not Applicable
20 Antioxidants Not Applicable
21 Platelet Aggregation Inhibitors Not Applicable
22 insulin Not Applicable
23 Insulin, Globin Zinc Not Applicable
24 Immunoglobulins
25 Antibodies

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency Completed NCT01371825 Phase 2, Phase 3 Sebelipase alfa (SBC-102)
2 Children With Lysosomal Acid Lipase Deficiency Who Previously Received Treatment With SBC-102 Terminated NCT01473875 Phase 2, Phase 3 SBC-102
3 Sitagliptin Versus Placebo in the Treatment of Non-alcoholic Fatty Liver Disease Completed NCT01963845 Phase 2 Sitagliptin;Placebo
4 Clinical Trial in Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency Active, not recruiting NCT02193867 Phase 2 sebelipase alfa
5 Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU) Unknown status NCT01169168
6 Assessement of the Prevalence of Lysosomal Acid Lipase Deficiency in Liver Post-transplant Patients Unknown status NCT02851550
7 Assessment of the Prevalence of Lysosomal Acid Lipase Deficiency in Patients Waiting for a Liver Transplant. Unknown status NCT02852304
8 The Efficacy of S-adenosyl Methionine (SAMe) Versus Pentoxiphylline in Patients With Non-alcoholic Steatohepatitis With Fibrosis Unknown status NCT02231333 Not Applicable S-adenosylmethionine (SAMe);pentoxiphylline (PTX)
9 Non Alcoholic Fatty Liver Disease (NAFLD) in Hong Kong Unknown status NCT00577044
10 Effect of Metformin on Disease Progression in Patients With Cryptogenic Cirrhosis (NASH-related Cirrhosis) With Diabetes or Impaired Glucose Tolerance or Insulin Resistance Completed NCT02234440 Not Applicable Metformin;Insulin
11 Genetic Studies of Non-Alcoholic Fatty Liver Disease Completed NCT01629095
12 Bartonella in Liver Transplant Patients Recruiting NCT02595710

Search NIH Clinical Center for Cryptogenic Cirrhosis

Genetic Tests for Cryptogenic Cirrhosis

Genetic tests related to Cryptogenic Cirrhosis:

# Genetic test Affiliating Genes
1 Cirrhosis, Cryptogenic 30

Anatomical Context for Cryptogenic Cirrhosis

MalaCards organs/tissues related to Cryptogenic Cirrhosis:

42
Liver, Skin, Breast, Heart, Testes, Neutrophil, Spinal Cord

Publications for Cryptogenic Cirrhosis

Articles related to Cryptogenic Cirrhosis:

(show top 50) (show all 121)
# Title Authors Year
1
Complete Heart Block due to Octreotide Infusion in Patient with Cryptogenic Cirrhosis. ( 30911266 )
2019
2
A growing hepatic mass in a cryptogenic cirrhosis patient. ( 29050462 )
2018
3
Is cryptogenic cirrhosis different from NASH cirrhosis? ( 29162389 )
2018
4
Liver Transplantation in Cryptogenic Cirrhosis: Outcome Comparisons Between NASH, Alcoholic, and AIH Cirrhosis. ( 29215462 )
2018
5
Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis B Related Liver Diseases and Cryptogenic Cirrhosis. ( 29892180 )
2018
6
Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet. ( 29948993 )
2018
7
Reply to: "NASH-related and cryptogenic cirrhosis similarities extend beyond cirrhosis": Cryptogenic cirrhosis should not be equated with NASH cirrhosis based on UNOS data mining and Bayesian 'doctrine of chances'. ( 29983203 )
2018
8
Raised plasma levels of H2S and nitrate predict intrapulmonary vascular dilations: A preliminary report in patients with cryptogenic cirrhosis. ( 29984390 )
2018
9
Liver Transplantation (LT) for Cryptogenic Cirrhosis (CC) and Nonalcoholic Steatohepatitis (NASH) Cirrhosis: Data from the Scientific Registry of Transplant Recipients (SRTR): 1994 to 2016. ( 30075518 )
2018
10
A decompensated cryptogenic cirrhosis? No, a late liver histiocytosis! ( 30077466 )
2018
11
The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options. ( 30144554 )
2018
12
NASH-related and cryptogenic cirrhosis similarities extend beyond cirrhosis. ( 30227919 )
2018
13
Pernicious anemia associated with cryptogenic cirrhosis: Two case reports and a literature review. ( 30278550 )
2018
14
Significance of Occult Hepatitis C Virus Infection in Liver Transplant Patients With Cryptogenic Cirrhosis. ( 30346262 )
2018
15
The post-transplant course of patients undergoing liver transplantation for nonalcoholic steatohepatitis versus cryptogenic cirrhosis: a retrospective case-control study. ( 27922486 )
2017
16
Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis. ( 28293093 )
2017
17
Severe reduction of blood lysosomal acid lipase activity in cryptogenic cirrhosis: A nationwide multicentre cohort study. ( 28396038 )
2017
18
Linking lysosomal acid lipase insufficiency to the development of cryptogenic cirrhosis. ( 28502381 )
2017
19
Cryptogenic cirrhosis: misunderstood cause of yellow urticaria. ( 28609562 )
2017
20
Cryptogenic Cirrhosis and Sitosterolemia: A Treatable Disease If Identified but Fatal If Missed. ( 29055934 )
2017
21
Cryptogenic Cirrhosis and Hepatopulmonary Syndrome in a Boy with Hepatic Hemangioma in Botswana: A Case Report and Review of the Literature. ( 29410927 )
2017
22
Liver Transplantation in Patients with Cryptogenic Cirrhosis Provides Excellent Long-Term Outcome. ( 26983869 )
2016
23
Recurrence of graft steatosis after liver transplantation for cryptogenic cirrhosis in recently commenced liver transplant program. ( 27142096 )
2016
24
Lysosomal Acid Lipase Activity Is Reduced Both in Cryptogenic Cirrhosis and in Cirrhosis of Known Etiology. ( 27219619 )
2016
25
Aneuploidy and asynchronous replication in non-alcholic fatty liver disease and cryptogenic cirrhosis. ( 27520584 )
2016
26
The Role of TEE in Diagnosing Hepatopulmonary Syndrome and Cryptogenic Cirrhosis. ( 27656299 )
2016
27
The Cause-and-Effect Relationship Between Type 2 Diabetes Mellitus and Clinically Overt Cryptogenic Cirrhosis: A Matter That Must Be Seriously Revised. ( 27822261 )
2016
28
Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic Cirrhosis. ( 28006764 )
2016
29
Cryptogenic cirrhosis: Current knowledge and future directions. ( 31041033 )
2016
30
Necrotic plaque on the calf and thigh of a woman with cryptogenic cirrhosis. ( 25814768 )
2015
31
Clinical outcomes of cryptogenic compared with non-cryptogenic cirrhosis: A retrospective cohort study. ( 25867030 )
2015
32
Histopathological Examination of Explanted Liver After Transplantation in Patients With Cryptogenic Cirrhosis. ( 26093740 )
2015
33
Clinical characteristics and outcome of hepatocellular carcinoma in alcohol related and cryptogenic cirrhosis: a prospective study. ( 26256085 )
2015
34
Synchronous hepatocellular carcinoma and cholangiocarcinoma in a patient transplanted for cryptogenic cirrhosis. ( 25184033 )
2014
35
Prevalence and molecular analysis of occult hepatitis B virus infection isolated in a sample of cryptogenic cirrhosis patients in iran. ( 24715933 )
2014
36
Can hepatitis e virus be considered as an etiology of cryptogenic cirrhosis? ( 24829744 )
2014
37
Liver transplantation in a patient with clinical manifestations of cryptogenic cirrhosis: a case report of hepar lobatum as a primary liver condition. ( 24998304 )
2014
38
Giant abdominal wall hernia in a patient with cryptogenic cirrhosis. ( 25093066 )
2014
39
Therapeutic effects of Iranian traditional medicine on a patient with cryptogenic cirrhosis. ( 25237567 )
2014
40
Cryptogenic cirrhosis and NASH: entities in evolution and involution. ( 25470867 )
2014
41
Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV. ( 22166370 )
2013
42
Use of serum vitamin B12 level as a marker to differentiate idiopathic noncirrhotic intrahepatic portal hypertension from cryptogenic cirrhosis. ( 22918688 )
2013
43
Cryptogenic cirrhosis is the leading cause for listing for liver transplantation in Sri Lanka. ( 23999684 )
2013
44
Occult hepatitis C virus infection in candidates for liver transplant with cryptogenic cirrhosis. ( 24082889 )
2013
45
Nephrectomy for a renal metastasis of undiagnosed hepatocellular carcinoma arising from an orthotopic liver transplant undertaken for cryptogenic cirrhosis. ( 24175048 )
2013
46
HFE Gene Mutations in Cryptogenic Cirrhosis Patients. ( 22451845 )
2012
47
Author's Reply: HFE Gene Mutations (C282Y and H63D) in a Group of Patients With Cryptogenic Cirrhosis. ( 22451846 )
2012
48
Iron overload and HFE mutations: are they relevant in cryptogenic cirrhosis? ( 22509192 )
2012
49
Unexplained findings of kayser-fleischer-like rings in a patient with cryptogenic cirrhosis. ( 22606437 )
2012
50
A case of breast cancer in a male patient with cryptogenic cirrhosis. ( 23018541 )
2012

Variations for Cryptogenic Cirrhosis

Expression for Cryptogenic Cirrhosis

Search GEO for disease gene expression data for Cryptogenic Cirrhosis.

Pathways for Cryptogenic Cirrhosis

GO Terms for Cryptogenic Cirrhosis

Cellular components related to Cryptogenic Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.96 F5 SERPINE1
2 cell periphery GO:0071944 8.62 KRT18 KRT8

Biological processes related to Cryptogenic Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.48 KRT18 KRT8
2 hemostasis GO:0007599 9.46 F2 F5
3 extrinsic apoptotic signaling pathway GO:0097191 9.43 KRT18 KRT8
4 blood circulation GO:0008015 9.4 F5 MTHFR
5 acute-phase response GO:0006953 9.37 F2 HFE
6 fibrinolysis GO:0042730 9.32 F2 SERPINE1
7 positive regulation of receptor-mediated endocytosis GO:0048260 9.26 HFE SERPINE1
8 positive regulation of blood coagulation GO:0030194 9.16 F2 SERPINE1
9 hepatocyte apoptotic process GO:0097284 8.96 KRT18 KRT8
10 negative regulation of fibrinolysis GO:0051918 8.62 F2 SERPINE1

Molecular functions related to Cryptogenic Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.13 F2 HFE SERPINE1
2 scaffold protein binding GO:0097110 8.62 KRT18 KRT8

Sources for Cryptogenic Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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