COP
MCID: CRY001
MIFTS: 36

Cryptogenic Organizing Pneumonia (COP)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Cryptogenic Organizing Pneumonia

MalaCards integrated aliases for Cryptogenic Organizing Pneumonia:

Name: Cryptogenic Organizing Pneumonia 12 53 59 44 15
Bronchiolitis Obliterans Organizing Pneumonia 12 53 59 73
Constrictive Bronchiolitis 53 73
Boop 12 53
Cop 53 59
Idiopathic Bronchiolitis Obliterans with Organizing Pneumonia 12
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia 53
Cryptogenic Organizing Pneumonitis 12
Organizing Pneumonia 53
Organized Pneumonia 73
Idiopathic Boop 53

Characteristics:

Orphanet epidemiological data:

59
cryptogenic organizing pneumonia
Inheritance: Not applicable; Prevalence: 1-9/100000 (Iceland); Age of onset: Adolescent,Adult,Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:0050157
ICD10 33 J84.116
ICD9CM 35 516.36
MeSH 44 D018549
NCIt 50 C62586
Orphanet 59 ORPHA1302
MESH via Orphanet 45 D018549
ICD10 via Orphanet 34 J84.1
UMLS via Orphanet 74 C0242770

Summaries for Cryptogenic Organizing Pneumonia

NIH Rare Diseases : 53 Bronchiolitis obliterans organizing pneumonia (BOOP) is a lung disease that causes inflammation in the small air tubes (bronchioles) and air sacs (alveoli). BOOP typically develops in individuals between 40-60 years old; however the disorder may affect individuals of any age. The signs and symptoms of BOOP vary but often include shortness of breath, a dry cough, and fever. BOOP can be caused by viral infections, various drugs, and other medical conditions. If the cause is known, the condition is called secondary BOOP. In many cases, the underlying cause of BOOP is unknown. These cases are called idiopathic BOOP or cryptogenic organizing pneumonia. Treatment often includes corticosteroid medications.

MalaCards based summary : Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to bronchiolitis obliterans and idiopathic interstitial pneumonia. An important gene associated with Cryptogenic Organizing Pneumonia is CXCL8 (C-X-C Motif Chemokine Ligand 8). The drugs Oseltamivir and Montelukast have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and neutrophil.

Disease Ontology : 12 An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

Wikipedia : 76 Cryptogenic organizing pneumonia (COP), also known as bronchiolitis obliterans organizing pneumonia... more...

Related Diseases for Cryptogenic Organizing Pneumonia

Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 11.6
2 idiopathic interstitial pneumonia 11.3
3 pneumonia 10.9
4 systemic lupus erythematosus 10.6
5 lupus erythematosus 10.6
6 leukemia 10.4
7 bronchiolitis 10.3
8 leukemia, chronic myeloid 10.2
9 hepatitis 10.2
10 lymphocytic leukemia 10.2
11 pneumothorax 10.2
12 hepatitis c 10.2
13 eosinophilic pneumonia 10.2
14 chronic eosinophilic pneumonia 10.2
15 acute respiratory distress syndrome 10.2
16 chronic graft versus host disease 10.2
17 adult respiratory distress syndrome 10.2
18 breast cancer 10.2
19 gastroesophageal reflux 10.1
20 leukemia, chronic lymphocytic 2 10.1
21 biliary cirrhosis, primary, 1 10.1
22 cryoglobulinemia, familial mixed 10.1
23 leukemia, chronic lymphocytic 10.1
24 pneumothorax, primary spontaneous 10.1
25 scleroderma, familial progressive 10.1
26 cystic fibrosis 10.1
27 granulomatosis with polyangiitis 10.1
28 malaria 10.1
29 leukemia, acute lymphoblastic 10.1
30 melioidosis 10.1
31 common variable immunodeficiency 10.1
32 neuromyelitis optica 10.1
33 primary biliary cirrhosis 10.1
34 chlamydia 10.1
35 cryptococcosis 10.1
36 plasmodium vivax malaria 10.1
37 panniculitis 10.1
38 limited scleroderma 10.1
39 cystitis 10.1
40 cryoglobulinemia 10.1
41 ischemia 10.1
42 myopathy 10.1
43 pulmonary coin lesion 10.1
44 acquired immunodeficiency syndrome 10.1
45 juvenile rheumatoid arthritis 10.1
46 influenza 10.1
47 lung disease 10.1
48 lymphosarcoma 10.1
49 evans' syndrome 10.1
50 achalasia 10.1

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to Cryptogenic Organizing Pneumonia

Symptoms & Phenotypes for Cryptogenic Organizing Pneumonia

Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

Drugs for Cryptogenic Organizing Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oseltamivir Approved Phase 2 204255-11-8, 196618-13-0 65028
2
Montelukast Approved Phase 2 158966-92-8 5281040
3
Ribavirin Approved Phase 2 36791-04-5 37542
4
Azithromycin Approved Phase 2 83905-01-5 55185 447043
5
Budesonide Approved Phase 2 51333-22-3 63006 5281004
6
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
7 Antibodies Phase 2
8 Immunoglobulins Phase 2
9 Immunoglobulins, Intravenous Phase 2
10 gamma-Globulins Phase 2
11 Leukotriene Antagonists Phase 2
12 Formoterol Fumarate Phase 2
13 Antineoplastic Agents, Hormonal Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
15 Hormones Phase 2
16 Antipyretics Phase 2
17 Budesonide, Formoterol Fumarate Drug Combination Phase 2
18 Respiratory System Agents Phase 2
19 Rho(D) Immune Globulin Phase 2
20 glucocorticoids Phase 2
21 Anti-Asthmatic Agents Phase 2
22 Anti-Inflammatory Agents Phase 2
23 Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT Completed NCT02036970 Phase 2 Bardoxolone methyl;Placebo
2 Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant Terminated NCT01432080 Phase 2 Prednisone;Azithromycin;Montelukast;Symbicort
3 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Cochrane evidence based reviews: cryptogenic organizing pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

Anatomical Context for Cryptogenic Organizing Pneumonia

MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

41
Lung, Breast, Neutrophil, B Cells, Bone, Spinal Cord, Pancreas

Publications for Cryptogenic Organizing Pneumonia

Articles related to Cryptogenic Organizing Pneumonia:

(show top 50) (show all 122)
# Title Authors Year
1
Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants. ( 28960643 )
2018
2
Cryptogenic organizing pneumonia masquerading as lung carcinoma: A case report and review of the literature. ( 29399056 )
2018
3
Oxaliplatin-induced bronchiolitis obliterans organizing pneumonia following hyperthermic intraperitoneal chemotherapy. ( 29998025 )
2018
4
Cryptogenic Organizing Pneumonia with Sarcoidosis Overlap: An Atypical Case Study. ( 30026760 )
2018
5
Nocardia brasiliensis Infection Complicating Cryptogenic Organizing Pneumonia. ( 28348912 )
2017
6
Cryptogenic Organizing Pneumonia With Lung Nodules Secondary to Pulmonary Manifestation of Crohn Disease. ( 28579861 )
2017
7
Cicatricial variant of cryptogenic organizing pneumonia. ( 28412206 )
2017
8
Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study. ( 28945804 )
2017
9
Retrospective evaluation of patients with organizing pneumonia: is cryptogenic organizing pneumonia different from secondary organizing pneumonia? ( 28621243 )
2017
10
Radial Probe Endobronchial Ultrasound-guided Lung Biopsy for Histopathological Diagnosis of Cryptogenic Organizing Pneumonia. ( 28091418 )
2017
11
Extracorporeal membrane oxygenation rescue in adolescent with bronchiolitis obliterans-organizing pneumonia like Wegener's granulomatosis. ( 28096986 )
2017
12
Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. ( 28266889 )
2017
13
Azacitidine-induced cryptogenic organizing pneumonia: a case report and review of the literature. ( 26791087 )
2016
14
Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature. ( 28081314 )
2016
15
Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. ( 28028949 )
2016
16
Erythema gyratum repens associated with cryptogenic organizing pneumonia. ( 26765132 )
2016
17
Spontaneous resolution of cryptogenic organizing pneumonia in pediatrics: A case report. ( 27021808 )
2016
18
Cryptogenic Organizing Pneumonia: IL-1I^, IL-6, IL-8, and TGF- I^1 Serum Concentrations and Response to Clarithromycin Treatment. ( 26987326 )
2016
19
LPS-Responsive Beige-Like Anchor Gene Mutation Associated With Possible Bronchiolitis Obliterans Organizing Pneumonia Associated With Hypogammaglobulinemia and Normal IgM Phenotype and Low Number of B Cells. ( 27888588 )
2016
20
Bronchiolitis Obliterans Organizing Pneumonia as an Initial Presentation of Systemic Lupus Erythematosus: A Rare Case Report and Literature Review. ( 27200095 )
2016
21
Macrolide therapy in cryptogenic organizing pneumonia: A case report and literature review. ( 25667636 )
2015
22
Haemoptysis as a primary manifestation of cryptogenic organizing pneumonia (COP). ( 27451594 )
2015
23
Reversed Halo Sign. A Case of Cryptogenic Organizing Pneumonia with Spontaneous Resolution. ( 26131991 )
2015
24
Successful Rituximab Therapy in Steroid-Resistant, Cryptogenic Organizing Pneumonia: A Case Series. ( 26045243 )
2015
25
A Case of Cryptogenic Organizing Pneumonia after Transarterial Chemoembolization for the Treatment of Hepatocellular Carcinoma. ( 26508948 )
2015
26
Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia. ( 26508933 )
2015
27
Increased Galectin-9 Concentration and Number of CD4+Foxp3high+Cells in Bronchoalveolar Lavage Fluid of Patients with Cryptogenic Organizing Pneumonia. ( 26249221 )
2015
28
Cryptogenic organizing pneumonia associated with invasive pulmonary aspergillosis: a case report and review of the literature. ( 25674228 )
2014
29
The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. ( 25493105 )
2014
30
Fatal case of cryptogenic organizing pneumonia associated with Everolimus. ( 25827702 )
2014
31
Bronchoalveolar lavage fluid and blood natural killer and natural killer T-like cells in cryptogenic organizing pneumonia. ( 24889556 )
2014
32
Cryptogenic organizing pneumonia in Sweet's syndrome: case report and review of the literature. ( 25196175 )
2014
33
Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia. ( 24460438 )
2014
34
Cryptogenic organizing pneumonia associated with radiation: A report of two cases. ( 24396439 )
2014
35
Association of cryptogenic organizing pneumonia in bilateral anterior uveitis. ( 25520652 )
2014
36
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. ( 24342432 )
2013
37
Autopsy findings of fatal cryptogenic organizing pneumonia. ( 23696931 )
2013
38
Cryptogenic organizing pneumonia in Tomm5(-/-) mice. ( 22688586 )
2013
39
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. ( 24090908 )
2013
40
Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation. ( 23933758 )
2013
41
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. ( 22842502 )
2013
42
Cryptogenic organizing pneumonia with fatal respiratory failure. ( 22372175 )
2012
43
Rituximab-related cryptogenic organizing pneumonia and late onset neutropenia in a patient with non-Hodgkin lymphoma: report of two rare complications and review of the literature. ( 23033310 )
2012
44
Simultaneous diagnosis of cryptogenic organizing pneumonia and HIV in a 45 year old man. ( 23569519 )
2012
45
Cryptogenic organizing pneumonia. ( 23001801 )
2012
46
Chronic exposure to particles caused bronchioloalveolar carcinoma in a patient with cryptogenic organizing pneumonia evaluated by elemental analysis. ( 21675931 )
2012
47
Anti-synthetase syndrome presenting as cryptogenic organizing pneumonia. ( 26029595 )
2012
48
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. ( 22109285 )
2011
49
Cryptogenic organizing pneumonia mimicking malignancy in a patient with rheumatoid arthritis. ( 21885507 )
2011
50
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. ( 21169342 )
2011

Variations for Cryptogenic Organizing Pneumonia

Expression for Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for Cryptogenic Organizing Pneumonia

GO Terms for Cryptogenic Organizing Pneumonia

Sources for Cryptogenic Organizing Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....