COP
MCID: CRY001
MIFTS: 53

Cryptogenic Organizing Pneumonia (COP)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Cryptogenic Organizing Pneumonia

MalaCards integrated aliases for Cryptogenic Organizing Pneumonia:

Name: Cryptogenic Organizing Pneumonia 12 52 58 43 15 17
Bronchiolitis Obliterans Organizing Pneumonia 12 52 58 71
Boop 12 52 58
Constrictive Bronchiolitis 52 71
Cop 52 58
Idiopathic Bronchiolitis Obliterans with Organising Pneumonia 12
Idiopathic Bronchiolitis Obliterans with Organizing Pneumonia 12
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia 52
Bronchiolitis Obliterans Organising Pneumonia 12
Cryptogenic Organising Pneumonitis 12
Cryptogenic Organizing Pneumonitis 12
Cryptogenic Organising Pneumonia 12
Organizing Pneumonia 52
Organized Pneumonia 71
Idiopathic Boop 52

Characteristics:

Orphanet epidemiological data:

58
cryptogenic organizing pneumonia
Inheritance: Not applicable; Prevalence: 1-9/100000 (Iceland); Age of onset: Adolescent,Adult,Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:0050157
ICD9CM 34 516.36
MeSH 43 D018549
NCIt 49 C62586
SNOMED-CT 67 719218000
ICD10 32 J84.116
MESH via Orphanet 44 D018549
ICD10 via Orphanet 33 J84.1
UMLS via Orphanet 72 C0242770
Orphanet 58 ORPHA1302
UMLS 71 C0242770 C0264383 C2350875

Summaries for Cryptogenic Organizing Pneumonia

NIH Rare Diseases : 52 Bronchiolitis obliterans organizing pneumonia (BOOP) is a lung disease that causes inflammation in the small air tubes (bronchioles) and air sacs (alveoli). BOOP typically develops in individuals between 40-60 years old; however the disorder may affect individuals of any age. The signs and symptoms of BOOP vary but often include shortness of breath, a dry cough, and fever. BOOP can be caused by viral infections, various drugs, and other medical conditions. If the cause is known, the condition is called secondary BOOP. In many cases, the underlying cause of BOOP is unknown. These cases are called idiopathic BOOP or cryptogenic organizing pneumonia . Treatment often includes corticosteroid medications.

MalaCards based summary : Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to idiopathic interstitial pneumonia and bronchiolitis obliterans. An important gene associated with Cryptogenic Organizing Pneumonia is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Sotalol and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone, and related phenotypes are fatigue and fever

Disease Ontology : 12 An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

Wikipedia : 74 Cryptogenic organizing pneumonia (COP), formerly known as bronchiolitis obliterans organizing pneumonia... more...

Related Diseases for Cryptogenic Organizing Pneumonia

Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 779)
# Related Disease Score Top Affiliating Genes
1 idiopathic interstitial pneumonia 32.9 SFTPD SFTPC CXCL8
2 bronchiolitis obliterans 31.7 TNF TIMP1 SFTPD MMP9 CXCL8 CRP
3 eosinophilic pneumonia 30.6 SFTPD MUC1 CXCL8
4 pulmonary fibrosis 30.5 TIMP1 SFTPD SFTPC MMP9 CXCL8
5 collagen disease 30.4 SFTPD CRP CD40LG
6 pericardial effusion 30.4 CRP CD40LG CD4
7 common cold 30.3 TNF CXCL8 CD4
8 pancytopenia 30.2 CRP CD8A CD40LG CD4
9 pneumothorax 30.1 TIMP1 MUC1 MMP9 CRP
10 sialadenitis 30.0 TNF CD8A CD4
11 nonspecific interstitial pneumonia 29.9 SFTPD SFTPC NLRC4 MUC1
12 bronchiolitis 29.8 TNF SFTPD CXCL8 CRP CD40LG
13 invasive aspergillosis 29.8 SFTPD CXCL8 CD4
14 interstitial pneumonitis, desquamative, familial 29.8 TNC SFTPD SFTPC MUC1
15 pustulosis of palm and sole 29.8 TNF CXCL8 CRP
16 bronchiectasis 29.8 TNF CXCL8 CRP
17 chlamydia 29.8 TNF CXCL8 CRP CD40LG
18 crohn's disease 29.8 TNF CXCL8 CRP CD4
19 igg4-related disease 29.8 PRTN3 CRP CD4
20 pulmonary emphysema 29.7 TIMP1 SFTPD SFTPC MMP9 CXCL8
21 retinal vasculitis 29.7 TNF CD40LG CD4
22 adult-onset still's disease 29.7 TNF CXCL8 CRP
23 echinococcosis 29.7 TNF CD8A CD40LG
24 nocardiosis 29.7 TNF CRP CD4
25 hypopyon 29.7 TNF CRP CD4
26 cryptococcosis 29.7 TNF CD8A CD4
27 adult respiratory distress syndrome 29.7 TNF SFTPD SFTPC CXCL8
28 acquired immunodeficiency syndrome 29.6 TNF CRP CD40LG CD4
29 proteasome-associated autoinflammatory syndrome 1 29.6 TNF MMP9 CXCL8 CRP
30 pulmonary hypertension 29.5 TNF TIMP1 SFTPC CXCL8 CRP
31 haemophilus influenzae 29.5 TNF CXCL8
32 antiphospholipid syndrome 29.5 TNF CRP CD40LG
33 ulcerative colitis 29.5 TNF PRTN3 CXCL8 CRP
34 bird fancier's lung 29.5 SFTPD MUC1 CD8A CD4
35 pulmonary embolism 29.5 SFTPD CRP CD40LG
36 mycobacterium abscessus 29.5 TNF CXCL8
37 osteoarthritis 29.4 TNF TIMP1 MMP9 CXCL8 CRP
38 scleritis 29.4 TNF PRTN3 MMP9 CRP
39 allergic hypersensitivity disease 29.4 TNF SFTPD CXCL8 CD4
40 arthritis 29.3 TNF TIMP1 MMP9 CXCL8 CRP
41 endocarditis 29.3 TNF CXCL8 CRP
42 aspiration pneumonitis 29.3 TNF CXCL8 CRP
43 thrombocytopenia 29.3 TNF MMP9 CXCL8 CRP CD40LG
44 vasculitis 29.3 TNF PRTN3 CRP CD40LG
45 bronchopneumonia 29.3 TNF CXCL8 CRP CD8A CD40LG CD4
46 demyelinating disease 29.2 TNF MMP9 CD8A CD40LG CD4
47 neutropenia 29.2 TNF CXCL8 CRP CD40LG
48 lung cancer susceptibility 3 29.2 SFTPD SFTPC MUC1 MMP9 LAMC2 CD8A
49 churg-strauss syndrome 29.2 TNF PRTN3 CXCL8 CD40LG
50 synovitis 29.2 TNF PRTN3 MMP9 CXCL8 CRP

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to Cryptogenic Organizing Pneumonia

Symptoms & Phenotypes for Cryptogenic Organizing Pneumonia

Human phenotypes related to Cryptogenic Organizing Pneumonia:

58 31 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
2 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
3 restrictive ventilatory defect 58 31 frequent (33%) Frequent (79-30%) HP:0002091
4 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
5 elevated erythrocyte sedimentation rate 58 31 frequent (33%) Frequent (79-30%) HP:0003565
6 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
7 neutrophilia 58 31 frequent (33%) Frequent (79-30%) HP:0011897
8 crackles 58 31 frequent (33%) Frequent (79-30%) HP:0030830
9 nonproductive cough 58 31 frequent (33%) Frequent (79-30%) HP:0031246
10 ground-glass opacification on pulmonary hrct 58 31 frequent (33%) Frequent (79-30%) HP:0025179
11 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
12 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
13 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
14 cyanosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000961
15 elevated c-reactive protein level 58 31 occasional (7.5%) Occasional (29-5%) HP:0011227
16 wheezing 58 31 occasional (7.5%) Occasional (29-5%) HP:0030828
17 bronchial breath sound 58 31 occasional (7.5%) Occasional (29-5%) HP:0031994
18 arthralgia 58 31 very rare (1%) Very rare (<4-1%) HP:0002829
19 respiratory distress 58 31 very rare (1%) Very rare (<4-1%) HP:0002098
20 hypoxemia 58 31 very rare (1%) Very rare (<4-1%) HP:0012418
21 pneumothorax 58 31 very rare (1%) Very rare (<4-1%) HP:0002107
22 night sweats 58 31 very rare (1%) Very rare (<4-1%) HP:0030166
23 pneumomediastinum 58 31 very rare (1%) Very rare (<4-1%) HP:0025421
24 dyspnea 58 Frequent (79-30%)
25 cough 58 Very frequent (99-80%)
26 abnormal sputum 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Cryptogenic Organizing Pneumonia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.44 CD4 CD40LG CD8A CRP LAMC2 MMP9

Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

Drugs for Cryptogenic Organizing Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
2 Neurotransmitter Agents Phase 4
3 Adrenergic Agents Phase 4
4 Sodium Channel Blockers Phase 4
5 Adrenergic Antagonists Phase 4
6 Sympatholytics Phase 4
7 Anti-Arrhythmia Agents Phase 4
8 Adrenergic beta-Antagonists Phase 4
9 Diuretics, Potassium Sparing Phase 4
10
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
11
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
12
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
13 Hormones Phase 3
14 Hormone Antagonists Phase 3
15 glucocorticoids Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Hydrocortisone 17-butyrate 21-propionate Phase 3
19 Hydrocortisone hemisuccinate Phase 3
20
Protein C Approved Phase 2
21
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
22
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
23
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
24
Montelukast Approved Phase 2 158966-92-8 5281040
25
Ribavirin Approved Phase 2 36791-04-5 37542
26
Oseltamivir Approved Phase 2 204255-11-8, 196618-13-0 65028
27
Azithromycin Approved Phase 2 83905-01-5 447043 55185
28
Budesonide Approved Phase 2 51333-22-3 63006 5281004
29
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
30 interferons Phase 2
31 Antiviral Agents Phase 2
32 Interferon-gamma Phase 2
33 Serine Proteinase Inhibitors Phase 2
34
protease inhibitors Phase 2
35 Alpha 1-Antitrypsin Phase 2
36 HIV Protease Inhibitors Phase 2
37 Trypsin Inhibitors Phase 2
38 Protein C Inhibitor Phase 2
39 Pharmaceutical Solutions Phase 2
40 Immunologic Factors Phase 2
41 Cyclosporins Phase 2
42 Immunosuppressive Agents Phase 2
43 Antifungal Agents Phase 2
44 Calcineurin Inhibitors Phase 2
45 Antirheumatic Agents Phase 2
46 Immunoglobulins Phase 2
47 Antibodies Phase 2
48 Adrenergic beta-Agonists Phase 2
49 Respiratory System Agents Phase 2
50 Anti-Asthmatic Agents Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Not yet recruiting NCT02347111 Phase 4 Flecainide;Sotalol
2 Efficacy and Safety of Corticosteroids in Oxygen-dependent Patients With COVID-19 Pneumonia in Grand Ouest Interregion France Not yet recruiting NCT04359511 Phase 3 Prednisone;Hydrocortisone
3 Eine Phase II Studie über Interferon Gamma 1b Zur Behandlung Der steroidrefraktären Bronchiolitis Obliterans Nach Allogener SZT Unknown status NCT01639261 Phase 2 Interferon gamma 1b
4 Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients Unknown status NCT01394835 Phase 2 Alpha -1 Antitrypsin;Alpha-1 Antitrypsin;AAT
5 A Dose-Ranging Study of the Efficacy and Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension Completed NCT02036970 Phase 2 Bardoxolone methyl;Placebo
6 Phase II Trial of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for Treatment of Bronchiolitis Obliterans Completed NCT01287078 Phase 2 Cyclosporine Inhalation Solution
7 Treatment of Newly Diagnosed Moderate or Severe Chronic Graft-versus-host Disease With Prednisone and Everolimus (PredEver First) - A Prospective Multicenter Phase IIA Study - Completed NCT01862965 Phase 2 PredEver
8 Does Increasing Immunosuppression Prevent Transplant-associated Lung-disease Triggered by Viral Respiratory Tract Infection Following Allogeneic Stem Cell Transplant? A Pilot Study Terminated NCT01432080 Phase 2 Prednisone;Azithromycin;Montelukast;Symbicort
9 Randomized Study of Early Treatment With Inhaled Corticosteroids Versus Observation for Patients Who Have Decreased Lung Function Status Post Allogeneic Stem Cell Transplantation Terminated NCT00656916 Phase 2 Fluticasone Propionate
10 Prospective, Phase I/II, Non-randomized, Open Label, Multicenter Study to Determine Safety and Efficacy of Nilotinib in a Population With Steroid-refractory/or Steroid-dependent cGVHD. Completed NCT01810718 Phase 1 nilotinib
11 Study of the Etiology and Immunological Pathogenesis in Acute Exacerbation of Idiopathic Pulmonary Fibrosis (AE-IPF) Unknown status NCT02509364
12 Evaluation of Regional Lung Function in U.S. Soldiers With Suspected Iraq-Afghanistan War Lung Injury Using 19F MRI Completed NCT03237364 Early Phase 1
13 The European IPF Registry - an Internet-based, Pan-European Registry Linked to the European IPF Biobank (eurIPFbank) Recruiting NCT02951416
14 Telemonitoring as a Tool for the Assessment of Treatment Effects of Connective Tissue Disease-associated Interstitial Lung Disease (TEL-CTD-ILD) Recruiting NCT04428957
15 Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection Recruiting NCT04416100
16 CXCL10 As a Biomarker Of Interstitial Lung Disease in Patients With Rheumatoid Arthritis Not yet recruiting NCT04356066
17 Incidence, Clinical Characteristics and Evaluation of Prognostic and Diagnostic Markers of Interstitial Pneumonia With Autoimmune Features (IPAF) - a Multicenter Prospective Study Not yet recruiting NCT03870828

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Cochrane evidence based reviews: cryptogenic organizing pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

Anatomical Context for Cryptogenic Organizing Pneumonia

MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

40
Lung, Breast, Bone, Bone Marrow, Liver, T Cells, Kidney

Publications for Cryptogenic Organizing Pneumonia

Articles related to Cryptogenic Organizing Pneumonia:

(show top 50) (show all 989)
# Title Authors PMID Year
1
Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome. 61
32447116 2020
2
Prognostic significance of the radiologic features of pneumonitis induced by anti-PD-1 therapy. 61
32150668 2020
3
Chest CT imaging features for prediction of treatment response in cryptogenic and connective tissue disease-related organizing pneumonia. 61
32040727 2020
4
Steroid resistance in organizing pneumonia caused by pulmonary cryptococcosis. 61
32280465 2020
5
Clinical and imaging characteristics of hematologic disease complicated by air leak syndrome: A STROBE-compliment observational study. 61
32443296 2020
6
Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia. 61
31892515 2020
7
Cryptogenic Organizing Pneumonia: Evolution of Morphological Patterns Assessed by HRCT. 61
32365469 2020
8
Findings on cryptogenic organizing pneumonia: a case report and literature review. 61
32321352 2020
9
Interstitial Lung Disease in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients: Comparison With Idiopathic Pulmonary Fibrosis. 61
32251058 2020
10
[Diffuse Intraparenchymal Mesothelioma: An Atypical Presentation]. 61
32035500 2020
11
Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study. 61
31392498 2020
12
Association of immune-related pneumonitis with the efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer. 61
32426052 2020
13
Cryptogenic Organizing Pneumonia with a Rare Radiographic Presentation of a Diffuse Micronodular Pattern Mimicking Miliary Lung Infiltration: A Case Report and Review of the Literature. 61
31976111 2020
14
Diagnosis and treatment of cryptogenic organizing pneumonia in a child on ECMO. 61
31469247 2020
15
Amiodarone-induced cryptogenic organizing pneumonia (COP). 61
31983617 2020
16
Two Cases of Primary Human Parainfluenza Virus 1 Pneumonia in Which Bronchoalveolar Lavage Fluid Yielded Human Parainfluenza Virus 1. 61
31511487 2020
17
Chemotherapy-induced pulmonary complications in cancer: Significance of clinicoradiological correlation. 61
32476746 2020
18
Lung Segmentation on HRCT and Volumetric CT for Diffuse Interstitial Lung Disease Using Deep Convolutional Neural Networks. 61
31396776 2019
19
Chronic, Silent Microaspiration Masquerading as Interstitial Lung Disease. 61
31813469 2019
20
A Case of Dermatomyositis Causing Cryptogenic Organizing Pneumonia. 61
31938589 2019
21
Hashimoto's thyroiditis-induced cryptogenic organizing pneumonia: A case report. 61
31807148 2019
22
Letter to the Editor - Late-onset neuromyelitis optica associated with cryptogenic organizing pneumonia. 61
31557682 2019
23
Anaplastic lymphoma kinase inhibitor related pneumonitis in patients with non-small cell lung cancer: Clinical and radiologic characteristics and risk factors. 61
31770246 2019
24
Expression of GR-α and HDAC2 in steroid-Sensitive and steroid-Insensitive interstitial lung disease. 61
31545224 2019
25
Exploring the Ability of Electronic Nose Technology to Recognize Interstitial Lung Diseases (ILD) by Non-Invasive Breath Screening of Exhaled Volatile Compounds (VOC): A Pilot Study from the European IPF Registry (eurIPFreg) and Biobank. 61
31623141 2019
26
Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 1. Introduction. 61
31172699 2019
27
Focal organizing pneumonia simulating lung malignancy: treated with prednisolone. 61
31406577 2019
28
Bronchiolitis obliterans organizing pneumonia in Crohn's disease. 61
30578017 2019
29
[Differences in small airway lesions in patients with different types of idiopathic interstitial pneumonia]. 61
31434411 2019
30
Thalidomide-induced bronchiolitis obliterans organizing pneumonia in a patient with multiple myeloma. 61
31464258 2019
31
Squawks in interstitial lung disease prevalence and causes in a cohort of one thousand patients. 61
31335692 2019
32
Patterns of onset and outcome of cryptogenic organizing pneumonia after allogeneic hematopoietic stem cell transplantation. 61
30972616 2019
33
[Reversed halo sign as an unusual manifestation of cryptogenic organized pneumonia. Report of one case]. 61
31859900 2019
34
Organizing pneumonia co-existing with carcinoid tumour: complete resolution with bronchoscopic tumour resection. 61
30891244 2019
35
Characteristics and outcomes of patients hospitalized with interstitial lung diseases in Spain, 2014 to 2015. 61
31124970 2019
36
[The role of histone deacetylases in the pathogenesis of idiopathic pulmonary fibrosis and cryptogenic organizing pneumonia]. 61
31137112 2019
37
Impact and safety of open lung biopsy in patients with acute respiratory distress syndrome (ARDS). 61
29501285 2019
38
Bleomycin-Induced Cryptogenic Organizing Pneumonia Manifested as Spontaneous Pneumothorax in a Patient with Classic Seminoma. 61
32411268 2019
39
Nivolumab-induced interstitial lung disease in a patient with gastric cancer. 61
30863551 2019
40
Predictive factors for relapse of cryptogenic organizing pneumonia. 61
30626371 2019
41
Cryptogenic Organizing Pneumonia Presenting as a Solitary Mass: Clinical, Imaging, and Pathologic Features. 61
30648699 2019
42
Refractory Metastatic Insulinoma Treated with Everolimus, Complicated by Cryptogenic Organizing Pneumonia. 61
31414042 2019
43
Viral Pneumonia Requiring Differentiation from Acute and Progressive Diffuse Interstitial Lung Diseases. 61
31839671 2019
44
[Post-transplant pulmonary complications: Guidelines from the francophone Society of bone marrow transplantation and cellular therapy (SFGM-TC)]. 61
30595221 2019
45
Concomitant Interstitial Lung Disease with Psoriasis. 61
31534591 2019
46
A long-term retrospective study of patients with biopsy-proven cryptogenic organizing pneumonia. 61
31159568 2019
47
Organizing pneumonia secondary to lung cancer of unknown primary site. 61
31312597 2019
48
Cyclophosphamide pulse therapy as treatment for severe interstitial lung diseases. 61
32476949 2019
49
Methotrexate-Associated Pneumonitis and Rheumatoid Arthritis-Interstitial Lung Disease: Current Concepts for the Diagnosis and Treatment. 61
31709258 2019
50
Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage. 61
31281686 2019

Variations for Cryptogenic Organizing Pneumonia

Expression for Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for Cryptogenic Organizing Pneumonia

Pathways related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TNF TIMP1 PRTN3 NLRC4 MUC1 MMP9
2
Show member pathways
13.08 TNF TIMP1 PRTN3 MUC1 MMP9 CXCL8
3
Show member pathways
12.71 TNF CXCL8 CD8A CD40LG CD4
4
Show member pathways
12 TNF SFTPD MUC1 CXCL8
5 11.71 TNC TIMP1 MMP9
6 11.66 TNF CD8A CD4
7
Show member pathways
11.61 TNF CXCL8 CD40LG
8 11.59 TNF CD8A CD4
9 11.46 TNF NLRC4 CXCL8
10 11.41 TNF TIMP1 MUC1 MMP9 CXCL8
11 11.39 TNF CXCL8 CD40LG
12 11.36 TNF TIMP1 CXCL8
13
Show member pathways
11.36 TNF MMP9 CXCL8 CD40LG
14 11.24 TIMP1 MMP9 LAMC2 CXCL8
15 11.22 TNC MUC1 MMP9
16 11.19 CD8A CD40LG CD4
17 10.82 TNF TIMP1 SFTPC MMP9 CXCL8
18 10.78 TNF TNC TIMP1 LAMC2 CXCL8 CD40LG
19 10.78 TNF CXCL8 CRP

GO Terms for Cryptogenic Organizing Pneumonia

Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF TNC TIMP1 SFTPD SFTPC PRTN3
2 extracellular matrix GO:0031012 9.46 TNC TIMP1 MMP9 LAMC2
3 extracellular space GO:0005615 9.44 TNF TNC TIMP1 SFTPD SFTPC PRTN3

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 TNF CXCL8 CD8A CD40LG CD4
2 extracellular matrix organization GO:0030198 9.71 TNF TNC MMP9 LAMC2
3 cellular protein metabolic process GO:0044267 9.56 TNC TIMP1 SFTPD SFTPC
4 inflammatory response GO:0006954 9.43 TNF NLRC4 HDAC9 CXCL8 CRP CD40LG
5 negative regulation of lipid storage GO:0010888 9.37 TNF CRP
6 cytokine-mediated signaling pathway GO:0019221 9.17 TNF TIMP1 PRTN3 MUC1 MMP9 CXCL8
7 regulation of immunoglobulin secretion GO:0051023 9.16 TNF CD40LG

Molecular functions related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 TNF SFTPD SFTPC NLRC4 MMP9 CRP
2 cytokine activity GO:0005125 8.92 TNF TIMP1 CXCL8 CD40LG

Sources for Cryptogenic Organizing Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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