MCID: CRY003
MIFTS: 50

Cryptosporidiosis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Cryptosporidiosis

MalaCards integrated aliases for Cryptosporidiosis:

Name: Cryptosporidiosis 12 75 53 59 55 43 3 44 15 72 33
Cryptosporidial Gastroenteritis 12 72
Infection by Cryptosporidium 12
Intestinal Cryptosporidiosis 12

Characteristics:

Orphanet epidemiological data:

59
cryptosporidiosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (United States),1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1733
ICD9CM 35 007.4
MeSH 44 D003457
NCIt 50 C128408
SNOMED-CT 68 58777003
ICD10 33 A07.2
MESH via Orphanet 45 D003457
ICD10 via Orphanet 34 A07.2
UMLS via Orphanet 73 C0010418
Orphanet 59 ORPHA1549
UMLS 72 C0010418 C0520796

Summaries for Cryptosporidiosis

MedlinePlus : 43 Cryptosporidiosis (crypto) is an illness caused by a parasite. The parasite lives in soil, food, and water. It may also be on surfaces that have been contaminated with feces (poop). You can become infected by swallowing the parasite, if it is in your food, drinking water, or water that you swim in. You can also get it by touching your mouth with contaminated hands. The most common symptom of crypto is watery diarrhea. Other symptoms include Dehydration Weight loss Stomach cramps or pain Fever Nausea Vomiting Contact your health care provider if you have watery diarrhea that lasts more than a few days. Most people with crypto get better without treatment within one to two weeks. But crypto can cause serious problems in people with weak immune systems, like those with HIV/AIDS. To reduce your risk of crypto, wash your hands often, only drink water that you know is safe, and wash or peel fresh fruits and vegetables before eating. Centers for Disease Control and Prevention

MalaCards based summary : Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to giardiasis and immune deficiency disease, and has symptoms including fever and pruritus. An important gene associated with Cryptosporidiosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are PAK Pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Azithromycin and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, lung and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

NIH Rare Diseases : 53 Cryptosporidiosis is an illness caused by the parasite, Cryptosporidium. The condition is most commonly associated with watery diarrhea. Other signs and symptoms may include dehydration, weight loss, stomach cramps, fever, nausea and/or vomiting. Cryptosporidiosis occurs when the parasite enters the body, often through contaminated food and water or because of poor handwashing hygiene. Although cryptosporidiosis can affect all people, young children, pregnant women and people with severely weakened immune systems (i.e. those with AIDS; cancer and transplant patients who are taking certain immunosuppressive drugs; and those with inherited diseases that affect the immune system) are likely to develop a more serious illness. Medications such as nitazoxanide have been used to treat diarrhea in both adults and children. However, most people who have healthy immune systems will recover without treatment.

CDC : 3 Many species and genotypes of the apicomplexan protozoan Cryptosporidium can infect humans and have a wide range of host animals. Zoonotic species and genotypes of Cryptosporidium are those transmitted from animal hosts to humans, and non-zoonotic species and genotypes are host-adapted without evidence of transmission from animals to humans. Cryptosporidium parvum (formerly known as C. parvum genotype II) and C. hominis (formerly known as C. parvum genotype I) are the leading causes of human cryptosporidiosis. C. meleagridis, C. felis, C. canis, C. ubiquitum, C. cuniculus, C. viatorum, Chipmunk genotype I, Cryptosporidium mink genotype, and C. muris can also infect humans.

Wikipedia : 75 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a genus of... more...

Related Diseases for Cryptosporidiosis

Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 giardiasis 31.3 TPI1 CD79A
2 immune deficiency disease 31.1 IL1A CD79A CD40LG
3 toxoplasmosis 30.5 DHFR CD79A CD40LG
4 bronchitis 30.4 VIP TAC1 CCL11
5 immunoglobulin alpha deficiency 30.4 CD79A CD40LG
6 strongyloidiasis 30.4 CD79A CCL11
7 constipation 30.3 VIP TAC1 SST
8 congenital hypogammaglobulinemia 30.2 IL1A CD79A
9 pneumocystosis 29.9 DHFR CD40LG CD4
10 proteasome-associated autoinflammatory syndrome 1 29.7 IL1A CXCL10 CCL11
11 malaria 29.0 IL1A DHFR CXCL10 CD40LG CCL11
12 cryptorchidism, unilateral or bilateral 11.3
13 diarrhea 11.1
14 acquired immunodeficiency syndrome 10.8
15 human immunodeficiency virus type 1 10.7
16 gastroenteritis 10.7
17 wdha syndrome 10.6 VIP SST
18 postgastrectomy syndrome 10.6 VIP SST
19 congenital rubella 10.6 CD40LG CAT
20 glucagonoma 10.6 VIP SST
21 c1q nephropathy 10.6 CD79A CD40LG
22 vipoma 10.6 VIP SST
23 pancreatic cholera 10.6 VIP SST
24 immunoglobulin g deficiency 10.6 CD79A CD40LG
25 anismus 10.6 VIP TAC1
26 acute diarrhea 10.6
27 cryofibrinogenemia 10.6 CD79A CD40LG
28 somatostatinoma 10.5 VIP SST
29 heparin-induced thrombocytopenia 10.5 CD79A CD40LG
30 congenital syphilis 10.5 CD79A CD40LG
31 syphilis 10.5 CD79A CD40LG
32 sporotrichosis 10.5 CD79A CD40LG
33 binswanger's disease 10.5 VIP SST
34 immunoglobulin a deficiency 1 10.5 CD79A CD40LG
35 secondary syphilis 10.5 CD79A CD40LG
36 acrodermatitis chronica atrophicans 10.5 CXCL10 CD40LG
37 ocular toxoplasmosis 10.5 CD79A CD40LG
38 breast abscess 10.5 CD40LG CAT
39 immunodeficiency-centromeric instability-facial anomalies syndrome 1 10.5 CD79A CD40LG
40 persistent generalized lymphadenopathy 10.5 CD79A CD40LG
41 diffuse pulmonary fibrosis 10.5 VIP TAC1
42 gastrinoma 10.5 VIP SST
43 immunodeficiency with hyper-igm, type 1 10.5 CD79A CD40LG
44 severe combined immunodeficiency 10.5
45 congenital toxoplasmosis 10.5 CD79A CD40LG
46 intestinal disease 10.4
47 japanese spotted fever 10.4 CXCL10 CCL11
48 pustulosis palmaris et plantaris 10.4 CD79A CD40LG
49 vasomotor rhinitis 10.4 VIP TAC1 CD40LG
50 scabies 10.4 IL1A CCL11

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to Cryptosporidiosis

Symptoms & Phenotypes for Cryptosporidiosis

UMLS symptoms related to Cryptosporidiosis:


fever, pruritus

MGI Mouse Phenotypes related to Cryptosporidiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CCL11 CD4 CD40LG CD79A CXCL10 DHFR
2 homeostasis/metabolism MP:0005376 9.85 CAT CD4 CD40LG CD79A CXCL10 DHFR
3 immune system MP:0005387 9.65 CCL11 CD4 CD40LG CD79A CXCL10 DHFR
4 normal MP:0002873 9.17 CCL11 CD4 CD79A SST TAC1 TPI1

Drugs & Therapeutics for Cryptosporidiosis

Drugs for Cryptosporidiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 447043 55185
2
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
3
Rifabutin Approved, Investigational Phase 3 72559-06-9 6323490 46783538
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Peginterferon alfa-2a Approved, Investigational Phase 2, Phase 3 198153-51-4 5360545
6
Ribavirin Approved Phase 2, Phase 3 36791-04-5 37542
7
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
8 Immunologic Factors Phase 2, Phase 3
9 Anti-Bacterial Agents Phase 3
10 14-alpha Demethylase Inhibitors Phase 3
11 Hormones Phase 3
12 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
13 Steroid Synthesis Inhibitors Phase 3
14 Antifungal Agents Phase 3
15 Cytochrome P-450 Enzyme Inhibitors Phase 3
16 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
17 Antibiotics, Antitubercular Phase 3
18 Hormone Antagonists Phase 3
19 Antitubercular Agents Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Liver Extracts Phase 2, Phase 3
22 Interferon-alpha Phase 2, Phase 3
23 Antiviral Agents Phase 2, Phase 3
24 Antimetabolites Phase 2, Phase 3
25 interferons Phase 2, Phase 3
26 Antiparasitic Agents Phase 3
27 Antiprotozoal Agents Phase 3
28 Anti-Infective Agents Phase 3
29
Paromomycin Approved, Investigational Phase 1, Phase 2 7542-37-2, 1263-89-4 165580
30
Clofazimine Approved, Investigational Phase 2 2030-63-9 2794
31 Anti-Inflammatory Agents Phase 2
32 Angiogenesis Inhibitors Phase 1, Phase 2
33 Angiogenesis Modulating Agents Phase 1, Phase 2
34 Adjuvants, Immunologic Phase 1, Phase 2
35 Interleukin-12 Phase 1, Phase 2
36
Loperamide Approved Phase 1 53179-11-6 3955
37
Spiramycin Approved Phase 1 24916-50-5
38 Antibodies Phase 1
39 Whey Protein Phase 1
40 Immunoglobulins Phase 1
41 Antidiarrheals Phase 1
42 Vaccines Phase 1
43
Iodine Approved, Investigational 7553-56-2 807
44 Diclazuril Investigational, Vet_approved 101831-37-2
45 gamma-Globulins
46 Immunoglobulins, Intravenous
47 Rho(D) Immune Globulin
48 cadexomer iodine

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients Completed NCT00002122 Phase 3 Azithromycin;Rifabutin;Fluconazole
2 Impact of Nitazoxanide on Virologic Responses in Chronic HCV Infected Patients With Genotype 4: A Placebo-controlled Randomized Trial Completed NCT01197157 Phase 2, Phase 3 Placebo;Nitazoxanide
3 Open Label, Multi-Center Evaluation of Nitazoxanide for the Treatment of Cryptosporidiosis in Subjects With AIDS in the United States Terminated NCT00004986 Phase 3 Nitazoxanide
4 A Double-Blind, Placebo-Controlled Trial of Paromomycin for Treatment of Cryptosporidiosis in Patients With Advanced HIV Disease and CD4 Counts Under 150 Cells/mm3 Completed NCT00000771 Phase 2 Paromomycin sulfate
5 A Phase II/III Placebo-Controlled Study of Nitazoxanide (NTZ) For Persons With AIDS and Cryptosporidiosis Completed NCT00001081 Phase 2 Nitazoxanide
6 A Phase I/II Open Label Study of Nitazoxanide (NTZ) for the Treatment of Cryptosporidium Parvum in HIV Infected Infants, Children, and Adolescents Completed NCT00055107 Phase 1, Phase 2 Nitazoxanide
7 Fecal Microbiota Transplantation in Refractory Clostridium Difficile Colitis Recruiting NCT02127398 Phase 2
8 A Phase 2A, Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety, Tolerability, Pharmacokinetics and Efficacy of Clofazimine (CFZ) in Cryptosporidiosis Terminated NCT03341767 Phase 2 Clofazimine;Placebo
9 A Pilot, Proof-of-Concept, Dose-Escalating Trial of Recombinant Human Interleukin-12 (rhIL-12) Versus Placebo Along With Paromomycin and Azithromycin for Chronic Cryptosporidiosis in AIDS Terminated NCT00057486 Phase 1, Phase 2 IL-12
10 A Randomized, Multicenter, Double-Blind, Parallel-Group, Placebo-Controlled Trial of the Efficacy and Safety of Bovine Anti-Cryptosporidium Immunoglobulin (BACI) in the Treatment of Cryptosporidium Enteritis in AIDS Patients Completed NCT00002248 Phase 1 Cryptosporidium Immune Whey Protein Concentrate (Bovine)
11 Blinded, Placebo-Controlled, Single-Dose Pharmacokinetics and Dose Escalation, Efficacy, and Safety Study of Letrazuril for AIDS-Related Cryptosporidial Diarrhea Completed NCT00001018 Phase 1 Letrazuril
12 Single-Blind Efficacy Evaluation of Intravenous Spiramycin in Subjects With AIDS-Related Cryptosporidial Diarrhea Completed NCT00000980 Phase 1 Spiramycin
13 Phase I/II Open Label Evaluation of Nitazoxanide for the Treatment of Cryptosporidiosis in AIDS Patients Completed NCT00002444 Phase 1 Nitazoxanide
14 Open-Label Compassionate Use of Nitazoxanide for the Treatment of Cryptosporidiosis in AIDS Patients Unknown status NCT00002158 Nitazoxanide
15 Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult. Unknown status NCT03166670
16 Efficacy of Cow's Milk Immune Globulin in the Treatment of Chronic Intestinal Cryptosporidiosis in Patients With AIDS Completed NCT00002264 Cryptosporidium Immune Whey Protein Concentrate (Bovine)
17 Prevalence and Clinical Presentation of Respiratory Cryptosporidiosis Among Children With Diarrhea in Mulago Hospital, Uganda Completed NCT00507871
18 Oral/Intravenous Azithromycin in the Treatment of Cryptosporidiosis in Patients Whose Disease Has Not Been Controlled by Conventional Therapy Completed NCT00002328 Azithromycin
19 Azithromycin in the Treatment of Cryptosporidiosis in Patients With Acquired Immune Deficiency Syndrome (AIDS): A Randomized, Multi-Center, Placebo-Controlled, Double-Blind Study Completed NCT00002082 Azithromycin
20 Open-Label "Compassionate" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients Completed NCT00002062 Spiramycin
21 28 Day Protocol for the Treatment of Cryptosporidiosis in AIDS Patients With Diclazuril (R64,433) Completed NCT00002278 Diclazuril
22 Protocol For the Treatment of Cryptosporidiosis in AIDS Patients With Diclazuril (R64,433) Completed NCT00002027 Diclazuril
23 Pilot Intervention Trial of Ceramic Water Filters to Reduce the Burden of Cryptosporidium in Household Drinking Water in Rural Kenya. Completed NCT01695304
24 Breast Milk Composition and HIV-exposed/Unexposed Early Infant Growth and Infectious Disease Events Completed NCT01699841
25 Field Studies of Human Immunity to Amebiasis in Bangladesh: A Prospective Study of Children Ages 0-17 Years Completed NCT02734264
26 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
27 Field Studies of Cryptosporidiosis and Enteropathogens in Bangladesh Active, not recruiting NCT02764918
28 A Pilot, Proof-of-Concept, Dose-Escalating Trial of Recombinant Human Interleukin-12 (rhIL-12) Versus Placebo Along With Paromomycin and Azithromycin for Chronic Cryptosporidiosis in AIDS Terminated NCT00001128 Interleukin-12;Paromomycin sulfate;Azithromycin
29 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Cryptosporidiosis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


nitazoxanide
Nitazoxanide

Cochrane evidence based reviews: cryptosporidiosis

Genetic Tests for Cryptosporidiosis

Anatomical Context for Cryptosporidiosis

MalaCards organs/tissues related to Cryptosporidiosis:

41
Small Intestine, Lung, Testes, Liver, T Cells, Colon, Breast

Publications for Cryptosporidiosis

Articles related to Cryptosporidiosis:

(show top 50) (show all 3283)
# Title Authors PMID Year
1
New insights into the detection and molecular characterization of Cryptosporidium with emphasis in Brazilian studies: a review. 38 17
31241657 2019
2
Cryptosporidiosis Outbreaks - United States, 2009-2017. 38 17
31246941 2019
3
A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors. 38 17
31015448 2019
4
Association of mannose-binding lectin deficiency with cryptosporidiosis. 9 38
16804842 2006
5
Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. 9 38
16804841 2006
6
Targeting DHFR in parasitic protozoa. 9 38
15718161 2005
7
Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS. 9 38
11054381 2000
8
Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum. 9 38
8855552 1996
9
Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening. 38
30451014 2019
10
Health sequelae of human cryptosporidiosis-a 12-month prospective follow-up study. 38
31302785 2019
11
Cellular immune response and scanning electron microscopy in the evaluation of Moringa leaves aqueous extract effect on Cryptosporidium parvum in buffalo intestinal tissue explants. 38
31406404 2019
12
Assessment of the first commercial multiplex PCR kit (ParaGENIE Crypto-Micro Real-Time PCR) for the detection of Cryptosporidium spp., Enterocytozoon bieneusi, and Encephalitozoon intestinalis from fecal samples. 38
31079868 2019
13
Evaluating respiratory cryptosporidiosis in pediatric diarrheal disease: protocol for a prospective, observational study in Malawi. 38
31426759 2019
14
Prevalence and risk factors associated with cryptosporidiosis among children within the ages 0-5 years attending the Limbe regional hospital, southwest region, Cameroon. 38
31429732 2019
15
Systematic gene silencing identified Cryptosporidium nucleoside diphosphate kinase and other molecules as targets for suppression of parasite proliferation in human intestinal cells. 38
31434931 2019
16
Prevalence of Cryptosporidium parvum in dairy calves and GP60 subtyping of diarrheic calves in central Argentina. 38
31187226 2019
17
Local weather, flooding history and childhood diarrhoea caused by the parasite Cryptosporidium spp.: A systematic review and meta-analysis. 38
31004904 2019
18
Invited review: A systematic review of the effects of early separation on dairy cow and calf health. 38
31079908 2019
19
Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum. 38
31362451 2019
20
A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity. 38
31231045 2019
21
The Prevalence of Cryptosporidium among Children Hospitalized because of Gastrointestinal Symptoms and the Efficiency of Diagnostic Methods for Cryptosporidium. 38
31115293 2019
22
The Cryptosporidium parvum gp60 glycoprotein expressed in the ciliate Tetrahymena thermophila is immunoreactive with sera of calves infected with Cryptosporidium oocysts. 38
31303202 2019
23
Prevalence of Cryptosporidium in dairy cattle in China during 2008-2018: A systematic review and meta-analysis. 38
31075427 2019
24
Multiple Independent Origins of Apicomplexan-Like Parasites. 38
31422883 2019
25
Identification of Cryptosporidium bat genotypes XVI-XVIII in bats from Brazil. 38
31076871 2019
26
Giardia and Cryptosporidium in children with diarrhea, Kufra, Libya, a North African migration route city. 38
31085111 2019
27
Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening. 38
30929953 2019
28
Solid-State Behavior and Solubilization of Flash Nanoprecipitated Clofazimine Particles during the Dispersion and Digestion of Milk-Based Formulations. 38
31038976 2019
29
Opportunistic intestinal parasites in immunocompromised patients from a tertiary hospital in Monterrey, Mexico. 38
31205040 2019
30
Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis. 38
30893435 2019
31
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis. 38
31249291 2019
32
Outbreak of cryptosporidiosis due to Cryptosporidium parvum subtype IIdA19G1 in neonatal calves on a dairy farm in China. 38
31071320 2019
33
Massive Cryptosporidium infections and chronic diarrhea in HIV-negative patients. 38
30976968 2019
34
Role of filtration in managing the risk from Cryptosporidium in commercial swimming pools - a review. 38
31095512 2019
35
Cross-sectional investigation of household transmission of Cryptosporidium in England and Wales: the epiCrypt study protocol. 38
31230003 2019
36
Cryptosporidium proventriculi sp. n. (Apicomplexa: Cryptosporidiidae) in Psittaciformes birds. 38
30981203 2019
37
Protocol standardization for the detection of Giardia cysts and Cryptosporidium oocysts in Mediterranean mussels (Mytilus galloprovincialis). 38
30903916 2019
38
Anticryptosporidial effect of pomegranate peels water extract in experimentally infected mice with special reference to some biochemical parameters and antioxidant activity. 38
31263326 2019
39
Long-term use of yeast fermentation products in comparison to halofuginone for the control of cryptosporidiosis in neonatal calves. 38
31079829 2019
40
Distribution of Cryptosporidium parvum gp60 subtypes in calf herds of Saxony, Germany. 38
30790038 2019
41
Cryptosporidium Sp. Findings and Its Symptomatology among Immunocompromised Patients. 38
31210801 2019
42
Fecal IgA against a sporozoite antigen at 12 months is associated with delayed time to subsequent cryptosporidiosis in urban Bangladesh: a prospective cohort study. 38
31131855 2019
43
Comparison of Cryptosporidium oocyst recovery methods for their applicability for monitoring of consumer-ready fresh shellfish. 38
30826538 2019
44
The Action of the Hexokinase Inhibitor 2-deoxy-d-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs. 38
30222231 2019
45
Prevalence and risk factors associated with Cryptosporidium spp. infection in local breed of dogs in Enugu State, Nigeria. 38
31327912 2019
46
Comparative analysis reveals conservation in genome organization among intestinal Cryptosporidium species and sequence divergence in potential secreted pathogenesis determinants among major human-infecting species. 38
31117941 2019
47
Evolutionary genomics of anthroponosis in Cryptosporidium. 38
30833731 2019
48
The transcriptome of Cryptosporidium oocysts and intracellular stages. 38
31133645 2019
49
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. 38
30894487 2019
50
Cryptosporidiosis Outbreak Investigation in a Canadian Correctional Facility Using Novel Case Finding Tools. 38
30866705 2019

Variations for Cryptosporidiosis

Expression for Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for Cryptosporidiosis

GO Terms for Cryptosporidiosis

Cellular components related to Cryptosporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 VIP TAC1 SST IL1A CXCL10 CD40LG
2 external side of plasma membrane GO:0009897 9.46 CXCL10 CD79A CD40LG CD4
3 extracellular space GO:0005615 9.23 TPI1 TAC1 SST IL1A CXCL10 CD40LG

Biological processes related to Cryptosporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.85 VIP TAC1 SST CXCL10 CCL11
2 cytokine-mediated signaling pathway GO:0019221 9.56 IL1A CXCL10 CD4 CCL11
3 cell surface receptor signaling pathway GO:0007166 9.46 SST CXCL10 CD79A CD4
4 response to radiation GO:0009314 9.43 CCL11 CAT
5 B cell proliferation GO:0042100 9.4 CD79A CD40LG
6 response to vitamin D GO:0033280 9.37 CXCL10 CD4
7 immune response GO:0006955 9.35 IL1A CXCL10 CD40LG CD4 CCL11
8 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.32 IL1A CD4
9 inflammatory response GO:0006954 9.02 TAC1 IL1A CXCL10 CD40LG CCL11

Molecular functions related to Cryptosporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.16 DHFR CAT
2 signaling receptor binding GO:0005102 9.13 CXCL10 CD4 CAT
3 cytokine activity GO:0005125 8.92 IL1A CXCL10 CD40LG CCL11

Sources for Cryptosporidiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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