MCID: CRY024
MIFTS: 20

Crystal Arthropathies

Categories: Bone diseases, Rare diseases
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Aliases & Classifications for Crystal Arthropathies

Summaries for Crystal Arthropathies

GARD: 19 Crystal arthropathies are a diverse group of bone diseases associated with the deposition of minerals within joints and the soft tissues around the joints. The group includes gout, basic calcium phosphate and calcium pyrophosphate dihydrate deposition diseases, and, in very rare cases, calcium oxalate crystal arthropathy which is a rare cause of arthritis characterized by deposition of calcium oxalate crystals within synovial fluid and typically occurs in patients with underlying primary or secondary hyperoxaluria. These crystals are responsible for different rheumatic syndromes, including acute or chronic synovial inflammation and cartilage degeneration.

MalaCards based summary: Crystal Arthropathies, also known as crystal arthropathy, is related to gout and chondrocalcinosis, and has symptoms including arthralgia and metatarsalgia. Affiliated tissues include bone and neutrophil.

Wikipedia: 75 Crystal arthropathy is a class of joint disorder (called arthropathy) that is characterized by... more...

Related Diseases for Crystal Arthropathies

Diseases related to Crystal Arthropathies via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 gout 10.5
2 chondrocalcinosis 10.5
3 tumoral calcinosis, hyperphosphatemic, familial, 1 10.3
4 arthropathy 10.2
5 osteoarthritis 10.2
6 tumoral calcinosis, normophosphatemic, familial 10.2
7 familial calcium pyrophosphate deposition 10.2
8 hyperuricemia 10.1
9 spinal stenosis 10.0
10 chondrocalcinosis 2 9.9
11 hemochromatosis, type 1 9.9
12 hypophosphatemia 9.9
13 hyperparathyroidism 9.9
14 hypothyroidism 9.9
15 synovitis 9.9
16 lipid metabolism disorder 9.9
17 spondylolisthesis 9.9
18 myeloma, multiple 9.9
19 cauda equina syndrome 9.9
20 glanders 9.9
21 adult-onset still's disease 9.9
22 bursitis 9.9
23 juvenile rheumatoid arthritis 9.9
24 septic arthritis 9.9
25 arthritis 9.9
26 systemic onset juvenile idiopathic arthritis 9.9

Graphical network of the top 20 diseases related to Crystal Arthropathies:



Diseases related to Crystal Arthropathies

Symptoms & Phenotypes for Crystal Arthropathies

UMLS symptoms related to Crystal Arthropathies:


arthralgia; metatarsalgia

Drugs & Therapeutics for Crystal Arthropathies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnostic Value of Dual-energy CT to Detect and Characterize Crystal Deposits in Patients With Hand Osteoarthritis Undergoing Hand Surgery: a Diagnostic Accuracy Study Completed NCT04585113
2 A Structured Nurse Led Patient Management Programme to Improve Outcomes in Gout: A Randomized Controlled Trial Active, not recruiting NCT03345186

Search NIH Clinical Center for Crystal Arthropathies

Genetic Tests for Crystal Arthropathies

Anatomical Context for Crystal Arthropathies

Organs/tissues related to Crystal Arthropathies:

MalaCards : Bone, Neutrophil

Publications for Crystal Arthropathies

Articles related to Crystal Arthropathies:

(show top 50) (show all 76)
# Title Authors PMID Year
1
[2022 Update of the Austrian Society for Rheumatology and Rehabilitation nutrition and lifestyle recommendations for patients with gout and hyperuricemia]. 62
36424414 2022
2
Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis. 62
35672096 2022
3
2022 update of the Austrian Society of Rheumatology and Rehabilitation nutrition and lifestyle recommendations for patients with gout and hyperuricemia. 62
35817987 2022
4
The Case of Disappearing Tibia in Rheumatoid Knee Tenosynovitis. 62
36199712 2022
5
Synovial fluid analysis for the enhanced clinical diagnosis of crystal arthropathies in a tertiary care institution. 62
33598809 2021
6
Identification and characterization of peripheral vascular color-coded DECT lesions in gout and non-gout patients: The VASCURATE study. 62
34198148 2021
7
The DIGICOD cohort: A hospital-based observational prospective cohort of patients with hand osteoarthritis - methodology and baseline characteristics of the population. 62
33689840 2021
8
[Diagnostic approach and differential diagnosis of mon- and oligoarthritis]. 62
33931837 2021
9
20 Years of Radiographic Imaging: Crystalline Deposits Causing Severe Arthropathy and Erosions. 62
33826727 2021
10
Calcium pyrophosphate deposition disease: The role of imaging in their detection and in differential diagnosis of crystal arthropathies. 62
32774579 2020
11
Updating the use of the Madrid Sonographic Enthesis Index (MASEI): a systematic review of the literature. 62
31750519 2020
12
Dual-energy CT in the differentiation of crystal depositions of the wrist: does it have added value? 62
31802167 2020
13
High-Performance Liquid Chromatography as a Novel Method for the Determination of α-Defensins in Synovial Fluid for Diagnosis of Orthopedic Infections. 62
31936486 2020
14
Prevalence and incidence of non-gout crystal arthropathy in southern Sweden. 62
31847885 2019
15
[Crystal arthropathies]. 62
31350748 2019
16
Clinical Utility of Multi-Energy Spectral Photon-Counting Computed Tomography in Crystal Arthritis. 62
30714678 2019
17
Elevated Procalcitonin in Acute Pseudogout Flare: A Case Report. 62
31410336 2019
18
[Update on Gout and Calcium pyrophosphate deposition (CPPD)]. 62
30086561 2018
19
Socio-economic inequalities in occurrence and health care costs in rheumatic and musculoskeletal diseases: results from a Spanish population-based study including 1.9 million persons. 62
29465359 2018
20
Advanced Imaging in the Diagnosis of Gout and Other Crystal Arthropathies. 62
29672810 2018
21
Systematic Overview of Solid Particles and Their Host Responses. 62
29892295 2018
22
Shoulder Lesion in a 69 Year Old Woman. 62
29772993 2018
23
Knee joint synovitis: study of correlations and diagnostic performances of ultrasonography compared with histopathology. 62
29531789 2018
24
Direct crystal formation from micronized bone and lactic acid: The writing on the wall for calcium-containing crystal pathogenesis in osteoarthritis? 62
30388106 2018
25
The value of musculoskeletal ultrasound in geriatric care and rehabilitation. 62
28692451 2017
26
Arthropathy in Dermatology: A Comprehensive Review. 62
28405546 2017
27
Increasing Public Health Burden of Arthritis and Other Rheumatic Conditions and Comorbidity: Results From a Statewide Health Surveillance System, 2007-2012. 62
26866827 2016
28
Hospital burden of gout, pseudogout and other crystal arthropathies in France. 62
25881756 2015
29
[Austrian nutrition and lifestyle recommendations for gout and hyperuricemia]. 62
26014619 2015
30
Hypophosphatasia: validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients. 62
25731960 2015
31
[Gout and and calcium pyrophosphate crystal arthropathies: pathophysiology]. 62
26165104 2015
32
Detection and characterization of crystal suspensions using single-source dual-energy computed tomography: a phantom model of crystal arthropathies. 62
25333310 2015
33
Use of ultrasound for diagnosis and monitoring of outcomes in crystal arthropathies. 62
25633243 2015
34
Persistent spontaneous synovial drainage from digital flexor sheath in proliferative tenosynovitis: Two case reports and a review of the literature. 62
26090353 2015
35
Crystal arthropathies: The NET is closing in on inflammation in gout. 62
24818672 2014
36
Comorbidities in patients with crystal diseases and hyperuricemia. 62
24703346 2014
37
Imaging in the crystal arthropathies. 62
24703345 2014
38
Gout and crystal arthropathies. 62
24703355 2014
39
Gout and crystal arthropathies. 62
24703354 2014
40
Doppler US in rheumatic diseases with special emphasis on rheumatoid arthritis and spondyloarthritis. 62
23996840 2014
41
[Differential diagnosis of inflammatory arthritis of the hip joint]. 62
23114660 2012
42
[Crystal arthropathies: what's new?]. 62
21795011 2011
43
[Crystal arthropathies]. 62
21512754 2011
44
[Ultrasound and arthritis]. 62
21128050 2010
45
Crystal arthropathies: recognizing and treating "the gouch". 62
21050952 2010
46
The role of uric acid and other crystals in osteoarthritis. 62
20425024 2010
47
[Chondrocalcinosis and calcium pyrophosphate (CPP) crystal deposition disease in 2010]. 62
20408460 2010
48
[Crystal arthropathies]. 62
19517095 2009
49
Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals. 62
18218665 2008
50
[Acute monarthritis]. 62
18078170 2007

Variations for Crystal Arthropathies

Expression for Crystal Arthropathies

Search GEO for disease gene expression data for Crystal Arthropathies.

Pathways for Crystal Arthropathies

GO Terms for Crystal Arthropathies

Sources for Crystal Arthropathies

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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