Cutaneous Adenocystic Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cutaneous Adenocystic Carcinoma

MalaCards integrated aliases for Cutaneous Adenocystic Carcinoma:

Name: Cutaneous Adenocystic Carcinoma ¹² ¹⁵

Adenoid Cystic Eccrine Carcinoma ¹² ⁷²

Adenoid Cystic Eccrine Carcinoma of Skin ¹²

Adenoid Cystic Carcinoma of the Skin ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4871

NCIt ⁵⁰ C4471

UMLS ⁷² C0346017

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Summaries for Cutaneous Adenocystic Carcinoma

MalaCards based summary : Cutaneous Adenocystic Carcinoma, also known as adenoid cystic eccrine carcinoma, is related to adenoid cystic carcinoma and basal cell carcinoma, and has symptoms including pain An important gene associated with Cutaneous Adenocystic Carcinoma is KRT8 (Keratin 8), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include skin, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

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Related Diseases for Cutaneous Adenocystic Carcinoma

Diseases related to Cutaneous Adenocystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)

#	Related Disease	Score	Top Affiliating Genes
1	adenoid cystic carcinoma	30.0	NFIB MYBL1 KRT7 KRT19
2	basal cell carcinoma	29.9	KRT8 KRT7 KRT19
3	adenoid basal cell carcinoma	29.3	LALBA KRT7 CEACAM5 B2M
4	neurenteric cyst	10.7	KRT8 KRT18
5	endolymphatic sac tumor	10.6	KRT8 KRT7
6	hidrocystoma	10.6	KRT8 KRT7
7	adenoid squamous cell carcinoma	10.6	KRT8 KRT7
8	cryptogenic cirrhosis	10.6	KRT8 KRT18
9	apocrine sweat gland neoplasm	10.6	KRT8 KRT7
10	nasal cavity cancer	10.6	KRT8 KRT7
11	epithelioid trophoblastic tumor	10.6	KRT7 KRT18
12	brooke-spiegler syndrome	10.6	KRT8 KRT7
13	metanephric adenoma	10.6	KRT7 KRT18
14	papillary ependymoma	10.6	KRT8 KRT18
15	seminal vesicle tumor	10.6	KRT7 KRT18
16	pleomorphic carcinoma	10.5	KRT8 KRT7
17	nasal cavity squamous cell carcinoma	10.5	KRT8 KRT7
18	atypical choroid plexus papilloma	10.5	KRT8 KRT7
19	basaloid squamous cell carcinoma	10.5	KRT8 KRT7
20	gastric tubular adenocarcinoma	10.4	KRT8 KRT7
21	mammary paget's disease	10.4	KRT8 KRT7
22	breast adenoid cystic carcinoma	10.4	NFIB MYBL1
23	ceruminoma	10.4	PIP KRT7
24	ovarian cystic teratoma	10.4	KRT7 B2M
25	oncocytic breast carcinoma	10.4	PIP KRT7
26	large intestine adenocarcinoma	10.4	PIP KRT7
27	lymphoepithelioma-like carcinoma	10.4	KRT8 KRT7 KRT18
28	nephrogenic adenofibroma	10.4	KRT8 KRT7 KRT18
29	microglandular adenosis	10.4	PIP KRT18
30	sweat gland cancer	10.4	KRT8 KRT7 KRT18
31	chromophobe renal cell carcinoma	10.4	KRT8 KRT7 KRT18
32	oncocytoma	10.4	KRT8 KRT7 KRT18
33	cecum adenocarcinoma	10.3	KRT7 B2M
34	transitional cell carcinoma	10.3	KRT8 KRT7 KRT18
35	epithelioid sarcoma	10.3	KRT8 KRT7
36	paget disease, extramammary	10.3	PIP KRT7
37	cutaneous mucoepidermoid carcinoma	10.3	KRT7 CEACAM5
38	malignant spiradenoma	10.3	KRT7 CEACAM5
39	mucinous adenofibroma	10.3	KRT7 CEACAM5
40	bile duct mucoepidermoid carcinoma	10.3	KRT7 CEACAM5
41	ovarian brenner tumor	10.3	KRT7 KRT18
42	ovarian lymphoma	10.3	KRT18 CEACAM5
43	bile duct cystadenocarcinoma	10.3	KRT7 CEACAM5
44	meibomian cyst	10.3	KRT7 CEACAM5
45	thymus adenocarcinoma	10.3	KRT7 CEACAM5
46	pancreatic serous cystadenoma	10.3	KRT7 CEACAM5
47	malignant biphasic mesothelioma	10.3	KRT7 CEACAM5
48	hidradenocarcinoma	10.2	PIP KRT7
49	rectum adenocarcinoma	10.2	KRT7 CEACAM5
50	mucinous ovarian cystadenoma	10.2	KRT7 CEACAM5

Graphical network of the top 20 diseases related to Cutaneous Adenocystic Carcinoma:

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Symptoms & Phenotypes for Cutaneous Adenocystic Carcinoma

UMLS symptoms related to Cutaneous Adenocystic Carcinoma:

pain

MGI Mouse Phenotypes related to Cutaneous Adenocystic Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.35	B2M KRT19 KRT8 NFIB PIP
2	endocrine/exocrine gland	MP:0005379	9.1	B2M KRT19 LALBA MYBL1 NFIB PIP

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Drugs & Therapeutics for Cutaneous Adenocystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Adenocystic Carcinoma

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Genetic Tests for Cutaneous Adenocystic Carcinoma

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Anatomical Context for Cutaneous Adenocystic Carcinoma

MalaCards organs/tissues related to Cutaneous Adenocystic Carcinoma:

⁴¹

Skin

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Publications for Cutaneous Adenocystic Carcinoma

Articles related to Cutaneous Adenocystic Carcinoma:

#	Title	Authors	PMID	Year
1	Immunohistochemical demonstration of myoepithelial cells in sweat gland carcinomas. ³⁸	Wach F...Eckert F	8186107	1994

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Genes for Cutaneous Adenocystic Carcinoma

Genes related to Cutaneous Adenocystic Carcinoma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT8	Keratin 8	Protein Coding	14.4	DISEASES inferred ¹⁵
2	KRT18	Keratin 18	Protein Coding	14.26	DISEASES inferred ¹⁵
3	KRT7	Keratin 7	Protein Coding	14.14	DISEASES inferred ¹⁵
4	NFIB	Nuclear Factor I B	Protein Coding	13.87	DISEASES inferred ¹⁵
5	B2M	Beta-2-Microglobulin	Protein Coding	13.56	DISEASES inferred ¹⁵
6	ACCS	1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)	Protein Coding	13.25	DISEASES inferred ¹⁵
7	MYBL1	MYB Proto-Oncogene Like 1	Protein Coding	6.09	DISEASES inferred ¹⁵
8	LALBA	Lactalbumin Alpha	Protein Coding	5.39	DISEASES inferred ¹⁵
9	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.3	DISEASES inferred ¹⁵
10	KRT19	Keratin 19	Protein Coding	3.87	DISEASES inferred ¹⁵
11	PIP	Prolactin Induced Protein	Protein Coding	3.29	DISEASES inferred ¹⁵

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Variations for Cutaneous Adenocystic Carcinoma

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Expression for Cutaneous Adenocystic Carcinoma

Search GEO for disease gene expression data for Cutaneous Adenocystic Carcinoma.

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Pathways for Cutaneous Adenocystic Carcinoma

Pathways related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	11.95	KRT8 KRT7 KRT19 KRT18
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.71	KRT8 KRT7 KRT19 KRT18
3	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	10.96	KRT8 KRT7 KRT19 KRT18
4	Signaling mediated by p38-alpha and p38-beta ¹	10.8	KRT8 KRT19

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GO Terms for Cutaneous Adenocystic Carcinoma

Cellular components related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.7	PIP KRT8 KRT7 KRT19 KRT18 CEACAM5
2	keratin filament	GO:0045095	9.43	KRT8 KRT7 KRT18
3	dystrophin-associated glycoprotein complex	GO:0016010	9.4	KRT8 KRT19
4	costamere	GO:0043034	9.37	KRT8 KRT19
5	apicolateral plasma membrane	GO:0016327	9.32	KRT8 KRT19
6	cell periphery	GO:0071944	9.13	KRT8 KRT19 KRT18
7	intermediate filament	GO:0005882	8.92	KRT8 KRT7 KRT19 KRT18

Biological processes related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	viral process	GO:0016032	9.62	KRT8 KRT7 KRT19 KRT18
2	extrinsic apoptotic signaling pathway	GO:0097191	9.43	KRT8 KRT18
3	retina homeostasis	GO:0001895	9.4	PIP B2M
4	sarcomere organization	GO:0045214	9.37	KRT8 KRT19
5	hepatocyte apoptotic process	GO:0097284	9.26	KRT8 KRT18
6	keratinization	GO:0031424	9.26	KRT8 KRT7 KRT19 KRT18
7	cell differentiation involved in embryonic placenta development	GO:0060706	9.16	KRT8 KRT19
8	cornification	GO:0070268	8.92	KRT8 KRT7 KRT19 KRT18

Molecular functions related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:0005198	8.32	KRT18

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Sources for Cutaneous Adenocystic Carcinoma

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