Cutaneous Adenocystic Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cutaneous Adenocystic Carcinoma

MalaCards integrated aliases for Cutaneous Adenocystic Carcinoma:

Name: Cutaneous Adenocystic Carcinoma ¹² ¹⁵

Adenoid Cystic Eccrine Carcinoma ¹² ⁷¹

Adenoid Cystic Eccrine Carcinoma of Skin ¹²

Adenoid Cystic Carcinoma of the Skin ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4871

NCIt ⁴⁹ C4471

UMLS ⁷¹ C0346017

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Summaries for Cutaneous Adenocystic Carcinoma

MalaCards based summary : Cutaneous Adenocystic Carcinoma, also known as adenoid cystic eccrine carcinoma, is related to adenoid basal cell carcinoma and basal cell carcinoma, and has symptoms including pain An important gene associated with Cutaneous Adenocystic Carcinoma is MYBL1 (MYB Proto-Oncogene Like 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include breast, skin and colon, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Cutaneous Adenocystic Carcinoma

Diseases related to Cutaneous Adenocystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)

#	Related Disease	Score	Top Affiliating Genes
1	adenoid basal cell carcinoma	29.7	LALBA KRT7 KIT ACCS
2	basal cell carcinoma	28.7	MME KRT8 KRT7 KRT5 KRT19 KIT
3	adenoid cystic carcinoma	28.2	PGR NFIB MYBL1 KRT7 KRT5 KRT19
4	neurenteric cyst	10.5	KRT8 KRT18
5	classic pulmonary blastoma	10.5	NKX2-1 CEACAM5
6	urethral villous adenoma	10.5	KRT7 CEACAM5
7	cutaneous mucoepidermoid carcinoma	10.5	KRT7 CEACAM5
8	seminal vesicle adenocarcinoma	10.5	KRT7 CEACAM5
9	pancreatic foamy gland adenocarcinoma	10.5	KRT7 CEACAM5
10	endolymphatic sac tumor	10.5	KRT8 KRT7
11	mucinous adenofibroma	10.5	KRT7 CEACAM5
12	aortic malignant tumor	10.5	KRT7 CEACAM5
13	urinary bladder villous adenoma	10.5	KRT7 CEACAM5
14	sigmoid neoplasm	10.5	KRT7 CEACAM5
15	mucinous intrahepatic cholangiocarcinoma	10.5	KRT7 CEACAM5
16	bile duct cystadenocarcinoma	10.5	KRT7 CEACAM5
17	colonic lymphangioma	10.5	KRT7 CEACAM5
18	jejunal adenocarcinoma	10.5	KRT7 CEACAM5
19	krukenberg carcinoma	10.5	KRT7 CEACAM5
20	vaginal tubulovillous adenoma	10.5	KRT7 CEACAM5
21	vaginal adenoma	10.5	KRT7 CEACAM5
22	mucinous ovarian cystadenoma	10.5	KRT7 CEACAM5
23	small cell carcinoma of the bladder	10.5	NKX2-1 KRT7
24	transverse colon cancer	10.5	KRT7 CEACAM5
25	appendiceal neoplasm	10.5	KRT7 CEACAM5
26	rete testis neoplasm	10.5	NKX2-1 KRT7
27	cryptogenic cirrhosis	10.5	KRT8 KRT18
28	liver lymphoma	10.5	MME CEACAM5
29	rete testis adenocarcinoma	10.5	NKX2-1 KRT7
30	biliary papillomatosis	10.5	KRT7 CEACAM5
31	appendix adenocarcinoma	10.4	KRT7 CEACAM5
32	ectopic thymus	10.4	NKX2-1 KRT8
33	solid adenocarcinoma with mucin production	10.4	NKX2-1 KRT7
34	idiopathic corneal edema	10.4	KRT8 KRT19
35	nephrogenic adenoma of urinary bladder	10.4	MME KRT7
36	wolffian duct adenoma	10.4	MME KRT7
37	liver sarcoma	10.4	KRT7 CEACAM5
38	synovium neoplasm	10.4	KRT8 KRT7
39	intrahepatic bile duct adenoma	10.4	KRT7 KRT19
40	bile duct adenoma	10.4	KRT7 KRT19
41	malignant struma ovarii	10.4	NKX2-1 KRT19
42	struma ovarii	10.4	NKX2-1 KRT19
43	mixed epithelial stromal tumour	10.4	MME KRT7
44	cervical adenoma malignum	10.4	MME KRT7
45	ovarian mucinous neoplasm	10.4	KRT7 CEACAM5
46	epididymal neoplasm	10.4	MME KRT7
47	ovarian wilms' cancer	10.4	MME KRT7
48	clear cell papillary renal cell carcinoma	10.4	MME KRT7
49	chromophil adenoma of the kidney	10.4	MME KRT7
50	tall cell variant papillary carcinoma	10.4	NKX2-1 KRT19

Graphical network of the top 20 diseases related to Cutaneous Adenocystic Carcinoma:

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Symptoms & Phenotypes for Cutaneous Adenocystic Carcinoma

UMLS symptoms related to Cutaneous Adenocystic Carcinoma:

pain

GenomeRNAi Phenotypes related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-153	9.5	KRT5
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-154	9.5	KRT18
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-17	9.5	KRT18 KRT5
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-33	9.5	KRT18
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-40	9.5	KRT8
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-68	9.5	KRT7
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-71	9.5	KRT18 KRT5 KRT7 KRT8
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-72	9.5	KRT7
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-84	9.5	KRT18
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-91	9.5	KRT5 KRT7

MGI Mouse Phenotypes related to Cutaneous Adenocystic Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.86	B2M KIT KRT19 KRT5 KRT8 NFIB
2	endocrine/exocrine gland	MP:0005379	9.81	B2M KIT KRT19 LALBA MYBL1 NFIB
3	integument	MP:0010771	9.56	B2M KIT KRT19 KRT5 LALBA MME
4	reproductive system	MP:0005389	9.23	B2M KIT KRT19 KRT8 MYBL1 NKX2-1

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Drugs & Therapeutics for Cutaneous Adenocystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Adenocystic Carcinoma

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Genetic Tests for Cutaneous Adenocystic Carcinoma

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Anatomical Context for Cutaneous Adenocystic Carcinoma

MalaCards organs/tissues related to Cutaneous Adenocystic Carcinoma:

⁴⁰

Breast, Skin, Colon, Lung, Thymus, Liver, Kidney

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Publications for Cutaneous Adenocystic Carcinoma

Articles related to Cutaneous Adenocystic Carcinoma:

#	Title	Authors	PMID	Year
1	Immunohistochemical demonstration of myoepithelial cells in sweat gland carcinomas. ⁶¹	Wach F...Eckert F	8186107	1994

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Genes for Cutaneous Adenocystic Carcinoma

Genes related to Cutaneous Adenocystic Carcinoma (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYBL1	MYB Proto-Oncogene Like 1	Protein Coding	6.22	DISEASES inferred ¹⁵
2	LALBA	Lactalbumin Alpha	Protein Coding	6.12	DISEASES inferred ¹⁵
3	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.25	DISEASES inferred ¹⁵
4	KRT8	Keratin 8	Protein Coding	4.93	DISEASES inferred ¹⁵
5	KRT18	Keratin 18	Protein Coding	4.87	DISEASES inferred ¹⁵
6	NKX2-1	NK2 Homeobox 1	Protein Coding	4.84	DISEASES inferred ¹⁵
7	KRT7	Keratin 7	Protein Coding	4.83	DISEASES inferred ¹⁵
8	MME	Membrane Metalloendopeptidase	Protein Coding	4.71	DISEASES inferred ¹⁵
9	KRT19	Keratin 19	Protein Coding	4.62	DISEASES inferred ¹⁵
10	NFIB	Nuclear Factor I B	Protein Coding	4.38	DISEASES inferred ¹⁵
11	B2M	Beta-2-Microglobulin	Protein Coding	4.38	DISEASES inferred ¹⁵
12	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	4.28	DISEASES inferred ¹⁵
13	PIP	Prolactin Induced Protein	Protein Coding	4.12	DISEASES inferred ¹⁵
14	ACCS	1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)	Protein Coding	4.1	DISEASES inferred ¹⁵
15	PGR	Progesterone Receptor	Protein Coding	3.54	DISEASES inferred ¹⁵
16	KRT5	Keratin 5	Protein Coding	3.4	DISEASES inferred ¹⁵

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Variations for Cutaneous Adenocystic Carcinoma

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Expression for Cutaneous Adenocystic Carcinoma

Search GEO for disease gene expression data for Cutaneous Adenocystic Carcinoma.

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Pathways for Cutaneous Adenocystic Carcinoma

Pathways related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	12.04	KRT8 KRT7 KRT5 KRT19 KRT18
2	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	11.81	KRT8 KRT7 KRT5 KRT19 KRT18
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.5	MME KIT CEACAM5
4	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.05	KRT8 KRT7 KRT5 KRT19 KRT18

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GO Terms for Cutaneous Adenocystic Carcinoma

Cellular components related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.81	PIP MME KRT8 KRT7 KRT5 KRT19
2	cell periphery	GO:0071944	9.43	KRT8 KRT19 KRT18
3	apicolateral plasma membrane	GO:0016327	9.4	KRT8 KRT19
4	costamere	GO:0043034	9.37	KRT8 KRT19
5	dystrophin-associated glycoprotein complex	GO:0016010	9.32	KRT8 KRT19
6	keratin filament	GO:0045095	9.26	KRT8 KRT7 KRT5 KRT18
7	intermediate filament	GO:0005882	9.02	KRT8 KRT7 KRT5 KRT19 KRT18

Biological processes related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lung development	GO:0030324	9.58	NKX2-1 NFIB MME
2	hepatocyte apoptotic process	GO:0097284	9.37	KRT8 KRT18
3	keratinization	GO:0031424	9.35	KRT8 KRT7 KRT5 KRT19 KRT18
4	cell differentiation involved in embryonic placenta development	GO:0060706	9.32	KRT8 KRT19
5	type II pneumocyte differentiation	GO:0060510	9.26	NKX2-1 NFIB
6	Clara cell differentiation	GO:0060486	9.16	NKX2-1 NFIB
7	cornification	GO:0070268	9.02	KRT8 KRT7 KRT5 KRT19 KRT18

Molecular functions related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	scaffold protein binding	GO:0097110	8.8	KRT8 KRT5 KRT18

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Sources for Cutaneous Adenocystic Carcinoma

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