Cutaneous Adenocystic Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Cutaneous Adenocystic Carcinoma

MalaCards integrated aliases for Cutaneous Adenocystic Carcinoma:

Name: Cutaneous Adenocystic Carcinoma ¹² ¹⁵

Adenoid Cystic Eccrine Carcinoma ¹² ⁷¹

Adenoid Cystic Eccrine Carcinoma of Skin ¹²

Adenoid Cystic Carcinoma of the Skin ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4871

NCIt ⁴⁹ C4471

SNOMED-CT ⁶⁷ 254711000 399968001

UMLS ⁷¹ C0346017

Sources

Summaries for Cutaneous Adenocystic Carcinoma

MalaCards based summary : Cutaneous Adenocystic Carcinoma, also known as adenoid cystic eccrine carcinoma, is related to adenoid basal cell carcinoma and basal cell carcinoma, and has symptoms including pain An important gene associated with Cutaneous Adenocystic Carcinoma is MYBL1 (MYB Proto-Oncogene Like 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Sources

Related Diseases for Cutaneous Adenocystic Carcinoma

Diseases related to Cutaneous Adenocystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 360)

#	Related Disease	Score	Top Affiliating Genes
1	adenoid basal cell carcinoma	29.9	LALBA KRT7 CEACAM5 ACCS
2	basal cell carcinoma	29.1	MME KRT8 KRT7 KRT5 KRT19 CEACAM5
3	adenoid cystic carcinoma	28.3	PGR NFIB MYBL1 KRT8 KRT7 KRT5
4	leukoplakia of penis	10.5	KRT7 CEACAM5
5	neurenteric cyst	10.5	KRT8 KRT18
6	pancreatic foamy gland adenocarcinoma	10.5	KRT7 CEACAM5
7	endolymphatic sac tumor	10.5	KRT8 KRT7
8	classic pulmonary blastoma	10.5	NKX2-1 CEACAM5
9	mucinous adenofibroma	10.5	KRT7 CEACAM5
10	larynx sarcoma	10.5	NKX2-1 CEACAM5
11	urinary bladder villous adenoma	10.5	KRT7 CEACAM5
12	cystitis cystica	10.5	KRT7 CEACAM5
13	mucinous intrahepatic cholangiocarcinoma	10.5	KRT7 CEACAM5
14	vaginal tubulovillous adenoma	10.5	KRT7 CEACAM5
15	bile duct cystadenocarcinoma	10.5	KRT7 CEACAM5
16	mucinous ovarian cystadenoma	10.5	KRT7 CEACAM5
17	ovarian cystadenoma	10.5	KRT7 CEACAM5
18	rectosigmoid junction neoplasm	10.5	KRT7 CEACAM5
19	sigmoid neoplasm	10.5	KRT7 CEACAM5
20	krukenberg carcinoma	10.4	KRT7 CEACAM5
21	biliary papillomatosis	10.4	KRT7 CEACAM5
22	transverse colon cancer	10.4	KRT7 CEACAM5
23	appendiceal neoplasm	10.4	KRT7 CEACAM5
24	colonic lymphangioma	10.4	KRT7 CEACAM5
25	mucocele of appendix	10.4	MME CEACAM5
26	appendix adenocarcinoma	10.4	KRT7 CEACAM5
27	cryptogenic cirrhosis	10.4	KRT8 KRT18
28	idiopathic corneal edema	10.4	KRT8 KRT19
29	small cell carcinoma of the bladder	10.4	NKX2-1 KRT7
30	liver sarcoma	10.4	KRT7 CEACAM5
31	synovium neoplasm	10.4	KRT8 KRT7
32	rete testis neoplasm	10.4	NKX2-1 KRT7
33	rete testis adenocarcinoma	10.4	NKX2-1 KRT7
34	nephrogenic adenoma of urinary bladder	10.4	MME KRT7
35	ureter small cell carcinoma	10.4	NKX2-1 KRT7
36	wolffian duct adenoma	10.4	MME KRT7
37	large intestine lipoma	10.4	NFIB CEACAM5
38	lipoma of colon	10.4	NFIB CEACAM5
39	mixed epithelial stromal tumour	10.4	MME KRT7
40	ovarian mixed germ cell neoplasm	10.4	MME CEACAM5
41	ovarian mucinous neoplasm	10.4	KRT7 CEACAM5
42	epididymal neoplasm	10.4	MME KRT7
43	ectopic thymus	10.4	NKX2-1 KRT8
44	intrahepatic bile duct adenoma	10.4	KRT7 KRT19
45	bile duct adenoma	10.4	KRT7 KRT19
46	clear cell papillary renal cell carcinoma	10.4	MME KRT7
47	chromophil adenoma of the kidney	10.4	MME KRT7
48	mucinous bronchioloalveolar adenocarcinoma	10.4	NKX2-1 KRT7
49	malignant struma ovarii	10.4	NKX2-1 KRT19
50	paratesticular lipoma	10.4	KRT19 CEACAM5

Graphical network of the top 20 diseases related to Cutaneous Adenocystic Carcinoma:

Sources

Symptoms & Phenotypes for Cutaneous Adenocystic Carcinoma

UMLS symptoms related to Cutaneous Adenocystic Carcinoma:

pain

GenomeRNAi Phenotypes related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-124	9.44	KRT18
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-127	9.44	KRT18
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-147	9.44	KRT18
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-153	9.44	KRT5
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-154	9.44	KRT18
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-182	9.44	KRT5
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-6	9.44	KRT8
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-63	9.44	KRT18
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-71	9.44	KRT18 KRT5 KRT7 KRT8
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-84	9.44	KRT18

MGI Mouse Phenotypes related to Cutaneous Adenocystic Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.5	B2M KRT19 KRT5 KRT8 NFIB NKX2-1
2	endocrine/exocrine gland	MP:0005379	9.23	B2M KRT19 LALBA MYBL1 NFIB NKX2-1

Sources

Drugs & Therapeutics for Cutaneous Adenocystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Adenocystic Carcinoma

Sources

Genetic Tests for Cutaneous Adenocystic Carcinoma

Sources

Anatomical Context for Cutaneous Adenocystic Carcinoma

MalaCards organs/tissues related to Cutaneous Adenocystic Carcinoma:

⁴⁰

Skin

Sources

Publications for Cutaneous Adenocystic Carcinoma

Articles related to Cutaneous Adenocystic Carcinoma:

#	Title	Authors	PMID	Year
1	Immunohistochemical demonstration of myoepithelial cells in sweat gland carcinomas. ⁶¹	Wach F...Eckert F	8186107	1994

Sources

Genes for Cutaneous Adenocystic Carcinoma

Genes related to Cutaneous Adenocystic Carcinoma (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYBL1	MYB Proto-Oncogene Like 1	Protein Coding	6.25	DISEASES inferred ¹⁵
2	LALBA	Lactalbumin Alpha	Protein Coding	5.82	DISEASES inferred ¹⁵
3	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.31	DISEASES inferred ¹⁵
4	KRT8	Keratin 8	Protein Coding	4.98	DISEASES inferred ¹⁵
5	KRT18	Keratin 18	Protein Coding	4.92	DISEASES inferred ¹⁵
6	KRT7	Keratin 7	Protein Coding	4.88	DISEASES inferred ¹⁵
7	NKX2-1	NK2 Homeobox 1	Protein Coding	4.88	DISEASES inferred ¹⁵
8	MME	Membrane Metalloendopeptidase	Protein Coding	4.74	DISEASES inferred ¹⁵
9	KRT19	Keratin 19	Protein Coding	4.66	DISEASES inferred ¹⁵
10	NFIB	Nuclear Factor I B	Protein Coding	4.38	DISEASES inferred ¹⁵
11	B2M	Beta-2-Microglobulin	Protein Coding	4.29	DISEASES inferred ¹⁵
12	PIP	Prolactin Induced Protein	Protein Coding	4.19	DISEASES inferred ¹⁵
13	ACCS	1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive)	Protein Coding	4.13	DISEASES inferred ¹⁵
14	PGR	Progesterone Receptor	Protein Coding	3.58	DISEASES inferred ¹⁵
15	KRT5	Keratin 5	Protein Coding	3.44	DISEASES inferred ¹⁵

Sources

Variations for Cutaneous Adenocystic Carcinoma

Sources

Expression for Cutaneous Adenocystic Carcinoma

Search GEO for disease gene expression data for Cutaneous Adenocystic Carcinoma.

Sources

Pathways for Cutaneous Adenocystic Carcinoma

Pathways related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	12.04	KRT8 KRT7 KRT5 KRT19 KRT18
2	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	11.81	KRT8 KRT7 KRT5 KRT19 KRT18
3	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.05	KRT8 KRT7 KRT5 KRT19 KRT18

Sources

GO Terms for Cutaneous Adenocystic Carcinoma

Cellular components related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.81	PIP MME KRT8 KRT7 KRT5 KRT19
2	cell periphery	GO:0071944	9.43	KRT8 KRT19 KRT18
3	apicolateral plasma membrane	GO:0016327	9.4	KRT8 KRT19
4	costamere	GO:0043034	9.37	KRT8 KRT19
5	dystrophin-associated glycoprotein complex	GO:0016010	9.32	KRT8 KRT19
6	keratin filament	GO:0045095	9.26	KRT8 KRT7 KRT5 KRT18
7	intermediate filament	GO:0005882	9.02	KRT8 KRT7 KRT5 KRT19 KRT18

Biological processes related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lung development	GO:0030324	9.58	NKX2-1 NFIB MME
2	hepatocyte apoptotic process	GO:0097284	9.37	KRT8 KRT18
3	keratinization	GO:0031424	9.35	KRT8 KRT7 KRT5 KRT19 KRT18
4	cell differentiation involved in embryonic placenta development	GO:0060706	9.32	KRT8 KRT19
5	type II pneumocyte differentiation	GO:0060510	9.26	NKX2-1 NFIB
6	Clara cell differentiation	GO:0060486	9.16	NKX2-1 NFIB
7	cornification	GO:0070268	9.02	KRT8 KRT7 KRT5 KRT19 KRT18

Molecular functions related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	scaffold protein binding	GO:0097110	8.8	KRT8 KRT5 KRT18

Sources

Sources for Cutaneous Adenocystic Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia