MCID: CTN009
MIFTS: 34

Cutaneous Adenocystic Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Adenocystic Carcinoma

MalaCards integrated aliases for Cutaneous Adenocystic Carcinoma:

Name: Cutaneous Adenocystic Carcinoma 12 15
Adenoid Cystic Eccrine Carcinoma 12 74
Adenoid Cystic Eccrine Carcinoma of Skin 12
Adenoid Cystic Carcinoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4871
NCIt 51 C4471
UMLS 74 C0346017

Summaries for Cutaneous Adenocystic Carcinoma

MalaCards based summary : Cutaneous Adenocystic Carcinoma, also known as adenoid cystic eccrine carcinoma, is related to adenoid cystic carcinoma and basal cell carcinoma, and has symptoms including pain An important gene associated with Cutaneous Adenocystic Carcinoma is KRT8 (Keratin 8), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include skin, breast and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cutaneous Adenocystic Carcinoma

Diseases related to Cutaneous Adenocystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.3 KRT19 KRT7 MYBL1 NFIB
2 basal cell carcinoma 29.9 KRT19 KRT7 KRT8
3 adenoid basal cell carcinoma 29.5 B2M CEACAM5 KRT7 LALBA
4 neurenteric cyst 10.4 KRT18 KRT8
5 endolymphatic sac tumor 10.4 KRT7 KRT8
6 hidrocystoma 10.4 KRT7 KRT8
7 adenoid squamous cell carcinoma 10.4 KRT7 KRT8
8 apocrine sweat gland neoplasm 10.4 KRT7 KRT8
9 cryptogenic cirrhosis 10.4 KRT18 KRT8
10 nasal cavity cancer 10.3 KRT7 KRT8
11 epithelioid trophoblastic tumor 10.3 KRT18 KRT7
12 brooke-spiegler syndrome 10.3 KRT7 KRT8
13 papillary ependymoma 10.3 KRT18 KRT8
14 seminal vesicle tumor 10.3 KRT18 KRT7
15 metanephric adenoma 10.3 KRT18 KRT7
16 pleomorphic carcinoma 10.3 KRT7 KRT8
17 nasal cavity squamous cell carcinoma 10.3 KRT7 KRT8
18 atypical choroid plexus papilloma 10.3 KRT7 KRT8
19 basaloid squamous cell carcinoma 10.3 KRT7 KRT8
20 pharynx cancer 10.3 MYBL1 NFIB
21 mammary paget's disease 10.3 KRT7 KRT8
22 gastric tubular adenocarcinoma 10.2 KRT7 KRT8
23 ceruminoma 10.2 KRT7 PIP
24 breast adenoid cystic carcinoma 10.2 MYBL1 NFIB
25 large intestine adenocarcinoma 10.2 KRT7 PIP
26 oncocytic breast carcinoma 10.2 KRT7 PIP
27 ovarian cystic teratoma 10.2 B2M KRT7
28 microglandular adenosis 10.2 KRT18 PIP
29 cecum adenocarcinoma 10.2 B2M KRT7
30 lymphoepithelioma-like carcinoma 10.2 KRT18 KRT7 KRT8
31 epithelioid sarcoma 10.2 KRT7 KRT8
32 nephrogenic adenofibroma 10.2 KRT18 KRT7 KRT8
33 paget disease, extramammary 10.2 KRT7 PIP
34 sweat gland cancer 10.2 KRT18 KRT7 KRT8
35 oncocytoma 10.2 KRT18 KRT7 KRT8
36 chromophobe renal cell carcinoma 10.2 KRT18 KRT7 KRT8
37 cutaneous mucoepidermoid carcinoma 10.2 CEACAM5 KRT7
38 transitional cell carcinoma 10.2 KRT18 KRT7 KRT8
39 mucinous adenofibroma 10.2 CEACAM5 KRT7
40 malignant spiradenoma 10.2 CEACAM5 KRT7
41 ovarian brenner tumor 10.2 KRT18 KRT7
42 bile duct mucoepidermoid carcinoma 10.2 CEACAM5 KRT7
43 ovarian lymphoma 10.2 CEACAM5 KRT18
44 bile duct cystadenocarcinoma 10.2 CEACAM5 KRT7
45 pancreatic serous cystadenoma 10.2 CEACAM5 KRT7
46 thymus adenocarcinoma 10.2 CEACAM5 KRT7
47 meibomian cyst 10.2 CEACAM5 KRT7
48 malignant biphasic mesothelioma 10.1 CEACAM5 KRT7
49 rectum adenocarcinoma 10.1 CEACAM5 KRT7
50 mucinous ovarian cystadenoma 10.1 CEACAM5 KRT7

Graphical network of the top 20 diseases related to Cutaneous Adenocystic Carcinoma:



Diseases related to Cutaneous Adenocystic Carcinoma

Symptoms & Phenotypes for Cutaneous Adenocystic Carcinoma

UMLS symptoms related to Cutaneous Adenocystic Carcinoma:


pain

GenomeRNAi Phenotypes related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.4 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.4 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.4 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.4 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT18 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.4 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 KRT7

MGI Mouse Phenotypes related to Cutaneous Adenocystic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 B2M KRT19 KRT8 NFIB PIP
2 endocrine/exocrine gland MP:0005379 9.1 B2M KRT19 LALBA MYBL1 NFIB PIP

Drugs & Therapeutics for Cutaneous Adenocystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Adenocystic Carcinoma

Genetic Tests for Cutaneous Adenocystic Carcinoma

Anatomical Context for Cutaneous Adenocystic Carcinoma

MalaCards organs/tissues related to Cutaneous Adenocystic Carcinoma:

42
Skin, Breast, Lung, Ovary, Thymus, Salivary Gland, Lymph Node

Publications for Cutaneous Adenocystic Carcinoma

Articles related to Cutaneous Adenocystic Carcinoma:

(show all 13)
# Title Authors Year
1
Lack of Deletion of 1p36 in 8 Cases of Primary Adenoid Cystic Carcinoma of the Skin. ( 30640762 )
2019
2
Small Subset of Adenoid Cystic Carcinoma of the Skin Is Associated With Alterations of the MYBL1 Gene Similar to Their Extracutaneous Counterparts. ( 29570128 )
2018
3
Primary Adenoid Cystic Carcinoma of the Skin with Multiple Local Recurrences. ( 26120310 )
2015
4
Primary adenoid cystic carcinoma of the skin metastatic to the lymph nodes: immunohistochemical study of a new case and literature review. ( 23812021 )
2014
5
Primary adenoid cystic carcinoma of the skin. ( 21699126 )
2011
6
Adenoid cystic carcinoma of the skin--an immunohistochemical and ultrastructural study. ( 7683029 )
1993
7
A comparative immunohistochemical study of adenoid cystic carcinoma of the skin and salivary glands. ( 1709341 )
1991
8
Cisplatin combination chemotherapy in squamous cell carcinoma and adenoid cystic carcinoma of the skin. ( 2551943 )
1989
9
Adenoid Cystic Carcinoma of the Skin. ( 28134218 )
1988
10
Primary adenoid cystic carcinoma of the skin. ( 2833370 )
1987
11
Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma. ( 3010759 )
1986
12
Recurrent adenoid cystic carcinoma of the skin managed by microscopically controlled surgery (Mohs surgery). ( 2420849 )
1986
13
Primary adenoid cystic carcinoma of the skin. ( 2990376 )
1985

Variations for Cutaneous Adenocystic Carcinoma

Expression for Cutaneous Adenocystic Carcinoma

Search GEO for disease gene expression data for Cutaneous Adenocystic Carcinoma.

Pathways for Cutaneous Adenocystic Carcinoma

Pathways related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 KRT18 KRT19 KRT7 KRT8
2
Show member pathways
11.71 KRT18 KRT19 KRT7 KRT8
3
Show member pathways
10.96 KRT18 KRT19 KRT7 KRT8
4 10.8 KRT19 KRT8

GO Terms for Cutaneous Adenocystic Carcinoma

Cellular components related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 B2M CEACAM5 KRT18 KRT19 KRT7 KRT8
2 keratin filament GO:0045095 9.43 KRT18 KRT7 KRT8
3 apicolateral plasma membrane GO:0016327 9.4 KRT19 KRT8
4 costamere GO:0043034 9.37 KRT19 KRT8
5 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT19 KRT8
6 cell periphery GO:0071944 9.13 KRT18 KRT19 KRT8
7 intermediate filament GO:0005882 8.92 KRT18 KRT19 KRT7 KRT8

Biological processes related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.62 KRT18 KRT19 KRT7 KRT8
2 extrinsic apoptotic signaling pathway GO:0097191 9.43 KRT18 KRT8
3 retina homeostasis GO:0001895 9.4 B2M PIP
4 sarcomere organization GO:0045214 9.37 KRT19 KRT8
5 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
6 keratinization GO:0031424 9.26 KRT18 KRT19 KRT7 KRT8
7 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT19 KRT8
8 cornification GO:0070268 8.92 KRT18 KRT19 KRT7 KRT8

Molecular functions related to Cutaneous Adenocystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.32 KRT18

Sources for Cutaneous Adenocystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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